九州大学 研究者情報
論文一覧
伊勢 裕彦(いせ ひろひこ) データ更新日:2019.12.11

准教授 /  先導物質化学研究所 分子集積化学部門 医用生物物理化学分野


原著論文
1. Hirohiko Ise ,Kumiko Matsunaga, Marie Shinohara, and Yasuyuki Sakai, Improved Isolation of Mesenchymal Stem Cells Based on Interactions between N-Acetylglucosamine-Bearing Polymers and Cell-Surface Vimentin, Stem Cells International, https://doi.org/10.1155/2019/4341286, 2019, 2019, 1-13, 2019.11.
2. Hirohiko Ise, Vimentin’s N-Acetylglucosamine-Binding Activity: Its Physiological Function, Trends Glycosci. Glycotechnol., 29, 169, E71-E79, 2017.09, Vimentin is known as a cytoskeletal protein that is expressed in mesenchymal and skeletal muscle tissues and plays an important role in the maintenance of the cytoplasmic architecture and cellular integrity. Moreover, vimentin is implicated in various cellular signal transduction pathways involved in cell proliferation and cell migration. Vimentin is highly expressed in lesion sites of various chronic diseases such as fibrosis, cancer, and autoimmune diseases. Vimentin’s high expression in various chronic diseases led to investigate its involvement in pathological mechanisms in chronic diseases. We recently reported that vimentin possesses N-acetyl-D-glucosamine (GlcNAc)-binding activity on cell surfaces. In this review, we describe vimentin’s GlcNAc-binding activity and discuss our hypothesis regarding its physiological relevance..
3. Hirohiko Ise, Sadanori Yamasaki, Kazuaki Sueyoshi, Yoshiko Miura, Elucidation of GlcNAc-binding properties of type III intermediate filament proteins, using GlcNAc-bearing polymers, Genes to Cells, 10.1111/gtc.12535, 22, 10, 900-917, 2017.10, [URL], Vimentin, desmin, glial fibrillary acidic protein (GFAP) and peripherin belong to type III intermediate filament family and are expressed in mesenchymal cells, skeletal muscle cells, astrocytes and peripheral neurons, respectively. Vimentin and desmin possess N-acetyl-d-glucosamine (GlcNAc)-binding properties on cell surfaces. The rod II domain of these proteins is a GlcNAc-binding site, which also exists in GFAP and peripherin. However, the GlcNAc-binding activities and behaviors of these proteins remain unclear. Here, we characterized the interaction and binding behaviors of these proteins, using various well-defined GlcNAc-bearing polymers synthesized by radical polymerization with a reversible addition-fragmentation chain transfer reagent. The small GlcNAc-bearing polymers strongly interacted with HeLa cells through vimentin expressed on the cell surface and interacted with vimentin-, desmin-, GFAP- and peripherin-transfected vimentin-deficient HeLa cells. These proteins present high affinity to GlcNAc-bearing polymers, as shown by surface plasmon resonance. These results show that type III intermediate filament proteins possess GlcNAc-binding activities on cell surfaces. These findings provide important insights into novel cellular functions and physiological significance of type III intermediate filaments..
4. Kim SJ, Ise H, Kim E, Goto M, Akaike T, Chung BH, Imaging and therapy of liver fibrosis using bioreducible polyethylenimine/siRNA complexes conjugated with N-acetylglucosamine as a targeting moiety, Biomaterials, 34, 6504-6514, 2013.09.
5. Komura K, Ise H, Akaike T, Dynamic behaviors of vimentin induced by interaction with GlcNAc molecules. Glycobiology, Glycobiology, 22, 1741-1759, 2012.12.
6. Ise H, Goto M, Akaike T, Engulfment and clearance of apoptotic cells based on a GlcNAc-binding lectin-like property of surface vimentin., Glycobiology, 22, 788-805, 2012.06.
7. Yu M, Du F, Ise H, Zhao W, Zhang Y, Yu Y, Yang J, Akaike T, Preparation and characterization of a VEGF-Fc fusion protein matrix for enhancing HUVEC growth, Biotechnol. Lett, 34, 1765-1771, 2012.11.
8. Minato A, Ise H, Goto M, Akaike T, Cardiac differentiation of embryonic stem cells by substrate immobilization of insulin-like growth factor binding protein 4 with elastin-like polypeptides, Biomaterials, 33, 515-523, 2012.01.
9. Kim SJ, Ise H, Goto M, Akaike T, Interactions of vimentin- or desmin-expressing liver cells with N-acetylglucosamine-bearing polymers, Biomaterials, 33, 2154-2164, 2012.03.
10. Ise M, Ise H, Shiba Y, Kobayashi S, Goto M, Takahashi M,, Akaike T, Ikeda U, Targeting N-acetylglucosamine-bearing polymer-coated liposomes to vascular smooth muscle cells., J Artif Organs., 14, 310-309, 2011.12.
11. Kim SJ, Ise H, Goto M, Komura K, Cho CS, Akaike T, Gene delivery system based on highly specific recognition of surface-vimentin with N-acetylglucosamine immobilized polyethylenimine., Biomaterials, 32, 3471-3480, 2011.05.
12. Ise H, Kobayashi S, Goto M, Sato T, Kawakubo M, Takahashi M,, Ikeda U, Akaike T, Vimentin and desmin possess GlcNAc-binding lectin-like properties on cell surfaces, Glycobiology, 20, 843-864, 2010.07.
13. Kobayashi S, Ise H, Takahashi M, Goto M, Akaike T, Ikeda U, Surface coating of bone marrow cells with N-acetylglucosamine for bone marrow implantation therapy., Biomaterials, 30, 574-582, 2009.02.
14. Aso S, Ise H, Takahashi M, Kobayashi S, Morimoto H, Izawa A, Goto M, Ikeda U, Effective uptake of N-acetylglucosamine-conjugated liposomes by cardiomyocytes in vitro., J. Control Release, 122, 189-198, 2007.09.
15. Misawa R, Ise H, Takahashi M, Morimoto H, Kobayashi E, Miyagawa S, Ikeda U, Development of liver regenerative therapy using glycoside-modified bone marrow cells., Biochem Biophys Res Commun., 342, 434-440, 2006.04.
16. Ise H, Nikaido T, Negishi N, Sugihara N, Suzuki F, Akaike T, Ikeda U, Effective hepatocyte transplantation using rat hepatocytes with low asialoglycoprotein receptor expression. , Am. J. Pathol. , 165, 501-510, 2004.09.
17. Ise H, Sugihara N, Negishi N, Nikaido T, Akaike T, Low Asialoglycoprotein Receptor Expression as Markers for Highly Proliferative Potential Hepatocytes., Biochem. Biophys. Res. Commun., 285, 172-182, 2001.08.
18. Ise H, Ferdous A, Sugihara N, Nikaido T, Negishi N, Akaike T, Separation of Mouse Hepatocytes of Distinct Biological Phenotypes Based on Their Asialoglycoprotein Receptor-mediated Binding Affinity to an Artificial Ligand. , Journal of Artificial Organs., 165, 501-510, 1999.07.
19. Ise H, Takashima S, Nagaoka M, Ferdous A, Akaike T, Analysis of cell viability and differential activity of mouse hepatocytes under 3D and 2D culture in agarose gel., Biotechnology Letters., 21, 209-213, 1999.01.
20. Misawa R, Soeda J, Ise H, Takahashi M, Kubota K, Mita A, Nakata T, Miyagawa S, Potential feasibility of early bone marrow cell injection into the spleen for creating functional hepatocytes. , Transplantation., 87, 1147-1154, 2009.04.
21. Shiba Y, Takahashi M, Hata T, Murayama H, Morimoto H, Ise H, Nagasawa T, Ikeda U, Bone marrow CXCR4 induction by cultivation enhances therapeutic angiogenesis. , Cardiovasc Res., 81, 169-177, 2009.04.
22. Murayama H, Takahashi M, Takamoto M, Shiba Y, Ise H, Koyama J, Tagawa Y, Iwakura Y, Ikeda U, Deficiency of tumour necrosis factor-alpha and interferon-gamma in bone marrow cells synergistically inhibits neointimal formation following vascular injury., Cardiovasc Res. , 80, 175-180, 2009.11.
23. Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumoto J, Ise H, Sagara J, Nakayama J, Taniguchi S, Ikeda U, Critical role of bone marrow-derived ASC, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice., Circulation, 117, 3079-3087, 2008.11.
24. Morimoto H, Hirose M, Takahashi M, Kawaguchi M, Ise H, Kolattukudy PE, Yamada M, Ikeda U., MCP-1 induces cardioprotection against ischemia/reperfusion injury: Role of reactive oxygen species. , Cardiovasc Res., 78, 554-562, 2008.11.
25. Nagaoka M, Ise H, Harada I, Koshimizu U, Maruyama A, Akaike T, Embryonic undifferentiated cells show scattering activity on a surface coated with immobilized E-cadherin. , J Cell Biochem., 103, 296-310, 2008.01.
26. Kubota K, Soeda J, Misawa R, Mihara M, Miwa S, Ise H, Takahashi M, Miyagawa S, Bone Marrow-derived Cells Fuse with Hepatic Oval Cells but are not involved in Hepatic Tumorigenesis in the Choline-deficient Ethionine-supplemented Diet Rat Model. , Carcinogenesis., 29, 448-454, 2008.02.
27. Tanabe T, Fujimoto K, Yasuo M, Tsushima K, Yoshida K, Ise H, Yamaya M, Modulation of mucus production by interleukin-13 receptor alpha in the human airway epithelium. , Clin Exp Allergy., 38, 122-134, 2008.09.
28. Ogawa R, Takahashi M, Hirose S, Morimoto H, Ise H, Murakami T, Yasue T, Kuriyama K, Hongo M, Kobayashi E, Ikeda U, A novel sphingosine-1-phosphate receptor agonist KRP-203 attenuates rat autoimmune myocarditis. , Biochem Biophys Res Commun. , 361, 621-628, 2007.09.
29. Morimoto H, Takahashi M, Shiba Y, Izawa A, Ise H, Hongo M, Hatake K, Motoyoshi K, Ikeda U, Bone marrow-derived CXCR4+ cells mobilized by macrophage colony-stimulating factor participate in the reduction of infarct area and improvement of cardiac remodeling after myocardial infarction in mice. , Am J Pathol. , 171, 755-766, 2007.09.
30. Hirose S, Takahashi M, Ogawa R, Morimoto H, Izawa A, Sato H, Ise H, Hongo M, Ikeda U, Erythropoietin attenuates the development of experimental autoimmune myocarditis. , Cardiovasc Drugs Ther. , 21, 17-27, 2002.02.
31. Shiba Y, Takahashi M, Yoshioka T, Yajima N, Morimoto H, Izawa A, Ise H, Hatake K, Motoyoshi K, Ikeda U, M-CSF accelerates neointimal formation in the early phase after vascular injury in mice: the critical role of the SDF-1-CXCR4 system., Arterioscler Thromb Vasc Biol. , 27, 283-289, 2007.02.
32. Morimoto H, Takahashi M, Izawa A, Ise H, Hongo M, Kolattukudy PE, Ikeda U, Cardiac overexpression of monocyte chemoattractant protein-1 in transgenic mice prevents cardiac dysfunction and remodeling after myocardial infarction. , Circ Res., 349, 781-788, 2007.10.
33. Suzuki C, Takahashi M, Morimoto H, Izawa A, Ise H, Hongo M, Hoshikawa Y, Ito T, Miyashita H, Kobayashi E, Shimada K, Ikeda U, Mycophenolate mofetil attenuates pulmonary arterial hypertension in rats., Biochem Biophys Res Commun. , 349, 781-788, 2006.10.
34. Matsunaga T, Kose E, Yasuda S, Ise H, Ikeda U, Determination of p-glycoprotein ATPase activity using luciferase., Biol Pharm Bull. , 29, 560-564, 2006.03.
35. Suzuki C, Takahashi M, Morimoto H, Izawa A, Ise H, Fujishiro J, Murakami T, Ishiyama J, Nakada A, Nakayama J, Shimada K, Ikeda U, Efficacy of mycophenolic acid combined with KRP-203, a novel immunomodulator, in a rat heart transplantation model., J Heart Lung Transplant., 25, 302-329, 2006.03.
36. Sato H, Takahashi M, Ise H, Yamada A, Hirose S, Tagawa Y, Morimoto H, Izawa A, Ikeda U, Collagen synthesis is required for ascorbic acid-enhanced differentiation of mouse embryonic stem cells into cardiomyocytes. , Biochem Biophys Res Commun., 342, 107-112, 2006.03.
37. Jia L, Takahashi M, Yoshioka T, Morimoto H, Ise H, Ikeda U, Therapeutic potential of endothelial progenitor cells for cardiovascular diseases., Curr Vasc Pharmacol., 4, 59-65, 2006.01.
38. Yoshioka T, Takahashi M, Shiba Y, Suzuki C, Morimoto H, Izawa A, Ise H, Ikeda U. , Granulocyte colony-stimulating factor (G-CSF) accelerates reendothelialization and reduces neointimal formation after vascular injury in mice., Cardiovasc Res., 70, 61-69, 2006.04.
39. Jia L, Takahashi M, Morimoto H, Takahashi S, Izawa A, Ise H, Iwasaki T, Hattori H, Wu KJ, Ikeda U, Changes in cardiac lipid metabolism during sepsis: the essential role of very low-density lipoprotein receptors. , Cardiovasc Res., 4, 545-555, 2005.02.
40. Suzuki F, Hashikura Y, Ise H, Ishida A, Nakayama J, Takahashi M,, Miyagawa S, Ikeda U, MCI-186 (edaravone), a free radical scavenger, attenuates hepatic warm ischemia-reperfusion injury in rats., Transpl Int., 18, 844-853, 2005.07.
41. Takahashi M, Takahashi S, Suzuki C, Jia L, Morimoto H, Ise H, Iwasaki T, Hattori H, Suzuki J, Miyamori I, Kobayashi E, Ikeda U, Interleukin-1beta attenuates beta-very low-density lipoprotein uptake and its receptor expression in vascular smooth muscle cells., J Mol Cell Cardiol., 38, 637-646, 2005.04.
42. Zhao P, Ise H, Hongo M, Ota M, Konishi I, Nikaido T, Human amniotic mesenchymal cells have some characteristics of cardiomyocytes., Transplantation, 79, 528-535, 2005.06.
43. Takashima S, Ise H, Zhao P, Akaike T, Nikaido T. , Human amniotic epithelial cells possess hepatocyte-like characteristics and functions. , Cell Struct Funct., 29, 73-84, 2004.06.
44. Matsunaga T, Maruyama M, Harada E, Katsuyama Y, Sugihara N, Ise H, Negishi N, Ikeda U, Expression and induction of CYP3As in human fetal hepatocytes. , Biochem Biophys Res Commun. , 318, 428-434, 2004.05.
45. Kobayashi M, Sugihara N, Ise H, Omasa T, Negishi N, Real time monitoriing of drug metabolic enzyme response inside human hepatoma GS-3A4-HepG2 cells by means of electrochemical impedance measurement. , Polymers for Advanced Technologie, 15, 232-243, 2004.10.
46. Nonaka H, Ise H, Sugihara N, Hirose S, Negishi N, Kondo Y, Akaike T, Development of Highly Functional Long-Term Culture Method of Liver Slice Embeded in Polymer Scaffold for Bioartificial Liver., Cell Transplantation , 12, 491-498, 2003.06.
47. Nagaoka M, Ise H, Akaike T, Immobilized E-cadherin model can enhance cell attachment and differentiation of primary hepatocytes but not proliferation., Biotechnology Letters , 24, 1857-1862, 2002.10.
48. Sugihara N, Ise H, Negishi N,, Nikaido T, Akaike T, Drug metabolic activity of cultured hepatocytes can synchronize with bile acid concentration in the medium. , Cell Biochem. Funct. , 20, 11-17, 2002.08.
49. Hirose S, Ise H, Uchiyama M, Cho CS, Akaike T, Regulation of Asialoglycoprotein Receptor Expression in the Proliferative State of Hepatocytes., Biochem. Biophys. Res. Commun. , 287, 675-681, 2002.10.
50. Yang J, Goto M, Ise H, Cho CS, Akaike T, Galactosylated alginate as a scaffold for hepatocytes entrapment. , Biomaterials, 23, 471-479, 2002.10.
51. Kakegawa T, Ise H, Sugihara N, Nikaido T, Negishi N, Akaike T, Tanaka E, Soluble Asialoglycoprotein Receptors Reflect the Apoptosis of Hepatocytes. , Cell Transplantation, 11, 407-415, 2002.09.
52. Uchida T, Serizawa T, Ise H, Akaike T, Akashi M, Graft Copolymer Having Hydrophobic Backbone and Hydrophilic Branches. 34. Interaction of Hepatocytes and Polystyrene Nanospheres Having Lactose-Immobilized Hydrophilic Polymers on Their Surfaces., Biomacromolecules, 2, 1343-1346, 2001.12.
53. Cho CS, Nah JW, Jeong YI, Cheon JB, Asayama S, Ise H, Akaike T, Coformational transition of nanoparticles composed of poly(g-benzyl L-glutamate) as the core and poly(ethylene oxide) as the shell. , Polymer., 40, 6769-6775, 1999.10.
54. Takei R, Park KH, Ise H, Maruyama A, Ebara Y, Okahata Y, Akaike T, Extracellular Matrix for Liver Tissue Engineering. , TISSUE ENGINEERING. , 3, 281-288, 1997.01.
55. Hori H, Noguchi N, Yokoyama H, Ise H, Jin CZ, Kasai S, Goto T, Taira Z, Design and synthesis of new mitochondrial cytotoxin N-thiadiazolylanilines that inhibit tumor cell growth., Bioorg Med Chem. , 4, 247-253, 1996.08.

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