Kyushu University Academic Staff Educational and Research Activities Database
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Tomohiro Yamada Last modified date:2018.06.27

Associate Professor / Division of Maxillofacial Diagnostic and Surgical Sciences
Department of Dental Science
Faculty of Dental Science


Graduate School
Undergraduate School
Other Organization


E-Mail
Phone
092-642-6452
Fax
092-642-6392
Academic Degree
PhD of Dental Medicine
Field of Specialization
Oral and maxillofacial sugery
Outline Activities
In Kyushu University Hospital, Oral and Maxillofacial Surgery, I provide medical treatment for maxillofacial congenital anomalies, acquired jaw deformities, and oral tumors. Besides, I make research activities for clarification of these diseases and development of novel therapeutic strategies. In addition, I teach practice guidance for undergraduate students and postgraduate residents, and research directions to graduate students.
Research
Research Interests
  • Reconstruction of temporomandibular joint
    keyword : temporomandibular joint, artificial TMJ, titanium
    1997.05~2014.05.
  • Studies for diagnosis and treatment for oral cancer
    keyword : oral cancer, diagnosis, treatment, hypoxia, GVHD
    2009.05~2018.05.
  • Basic and clinical research for developmental jaw deformnities
    keyword : jaw deformity, treatment strategy
    2001.05~2018.03.
  • Basic and clinical research for congenital oral deformities.
    keyword : cleft lip and palate, development, prevention
    1993.05~2014.05.
Current and Past Project
  • Although the cause of the jaw asymmetry seems to be likely to be due to dysfunction of muscle, so far there is little report on muscle function and histological examination of the same disease. Facial forms without reported in Japan of the things about the context of the vertical dimension and masticatory muscles there is a report of the research team of Western, non-deflection side in the lower jaw asymmetry patients in the application authors of the three-dimensional analysis is long face, polarized place side was focused on the molecular pathological nature of the masticatory muscles from having the morphological characteristics of the short face. So do the muscle biopsy of the mandibular asymmetry cases in this study, the type of muscle fibers, as well as examine the difference between the left and right of expression of muscle and bone-related marker gene, clarify the relationship with the other evaluation items of jaw deformity.
Academic Activities
Papers
1. Tomohiro Yamada, Azumi Hirata, Eri Sasabe, Tomohide Yoshimura, Seiji Ohno, Naoya Kitamura, Tatsuya Yamamoto, TCDD disrupts posterior palatogenesis and causes cleft palate., J Craniomaxillofacial Surgery, 42, 1, 1-6, 2014.01, Dioxins (e.g. 2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD) cause cleft palate at a high rate. A post-fusional split may contribute to the pathogenesis, and tissue fragility may be a concern. The objective of this study was to investigate the effects of TCDD on the palatal epithelium, bone and muscle, which contribute to tissue integrity.
ICR mice (10–12 weeks old) were used. TCDD was administered on E12.5 at 40 mg/kg. Immunohistochemical staining for AhR, ER-α, laminin, collagen IV, osteopontin, Runx2, MyoD, and desmin were performed. Furthermore, western blot analysis for osteopontin, Runx2, MyoD, and desmin were performed to evaluate protein expression in the palatal tissue.
Immunohistologically, there was little difference in the collagen IV and laminin localization in the palatal epithelium between control versus TCDD-treated mice. Runx2 and osteopontin immunoreactivity decreased in the TCDD-treated palatal bone, and MyoD and desmin decreased in the TCDD-treated palatal muscle. AhR and ER-α immunoreactivity were localized to the normal palatal bone, but ER-α was diminished in the TCDD-treated palate. On western blot analysis, Runx2, MyoD, and desmin were all downregulated in the TCDD-treated palate.
TCDD may suppress palatal osteogenesis and myogenesis via AhR, and cause cleft palates via a post-fusional split mechanism, in addition to a failure of palatal fusion..
Membership in Academic Society
  • Japan Society for Oral Tumors
  • Japanese Society of Oral Medicine
  • The Japanese Teratology Society
  • Japanese Academy of Maxillofacial Implants
  • The Japanese Society of Oral Diagnosis/Oral Medicine
  • Japanese Society of Oral Therapeutics and Pharmacology
  • Japanese Stomatological Society
  • Japanese Cleft Palate Association
  • The Japanese Society for Jaw Deformities
  • Japanese Society of Oral and Maxillofacial Surgeons
Educational
Educational Activities
For undergraduate students, I make lectures mainly on maxillofacial trauma and neurological orofacial diseases, and guidance in clinical practice.
In addition, I have been researching guidance around the pathological conditions for congenital and developmental abnormalities, and oncology of the maxillofacial region for graduate students.
Other Educational Activities
  • 2018.06.
Social
Professional and Outreach Activities
While helping the International Cleft Palate Foundation, it is mainly carried out medical assistance activities to Vietnam.