|Nogami Hirofumi||Last modified date：2018.08.05|
Assistant Professor / Desigh ・ Bio-system / Department of Mechanical Engineering / Faculty of Engineering
|1.||Hirofumi Nogami, Ryo Inoue, Ryuta Shiraishi, Yuki Seki, and Renshi Sawada, Stress monitoring of cows using an integrated optical photoplethysmographic sensor, BIO4APPS2017, 2018.12, Detecting the stress level of cows is one of the important purposes for a cow health monitoring system. This is because high stress causes not only lowered resistance to illnesses but also estrus failure. Both electrocardiographic monitors and photoplethysmographic (PPG) sensors can measure stress intensity. The electrocardiographic monitors, which can accurately measure the rate and rhythm of heartbeats, are useful to detect stress intensity. However, long-term usage is not suitable due to its operating with electrodes. On the other hand, PPG sensors can be attached to the cow’s tail for long term monitoring. Thus, we have developed wearable type PPG sensors and attempted to detect stress intensity..|
|2.||Ryo Inoue, Hirofumi Nogami, Eiji Higurashi and Renshi Sawada, New Extremely Small Sensor for Reliable Blood Flow Measurement, BIOSTEC2018 , 2018.01, Although a number of laser Doppler blood flow sensors have been developed over the past few decades, they remain uncommon in practice. This is because the contact pressure between the skin and the sensor is not measured simultaneously with blood flow, despite the fact that blood flow is greatly affected by contact pressure. Thus, reliable and highly reproducible measurement of the blood flow could not be realized. In addition, the changes of beam condition or body temperature also have effect on the blood flow measurement. Therefore, we have fabricated a micro electro mechanical systems (MEMS) blood flow sensor which can measure the contact pressure, the beam power and the body temperature, for reliable and highly reproducible measurement..|
|3.||Hirofumi Nogami, Ryo Inoue, Yuma Hayashida, Hideyuki Ando, Takahiro Ueno, and Renshi
Sawada, Multifunctional optical sensor module Integrate1d optical micro displacement sensor and its application to a
photoplethysmographic sensor with measuring contact force, BIOSTEC2018 , 2018.01, Photoplethysmography (PPG) is widely and commonly used, as it produces a wide range of information, such
as stress level, heart rate interval, respiration rate, blood vessel hardness, etc. It is necessary to control the
contact force between a PPG sensor and the measurement location (the skin surface), in order to obtain an
accurate PPG signal. We propose new multifunctional sensor modules that can measure both pulse waves and
contact force. The sensor module has a micro integrated displacement sensor chip with an optical source,
photo diodes, and op-amp circuits, and a gum frame with a mirror. Some incident light penetrates into a finger,
and the scattered light, which contains a biological signal (a pulse wave), is detected by one photodiode. The
photodiode can also detect reflected light from a mirror, which is displaced by a contact force. In this paper,
we fabricate a multifunctional sensor module and attempt to simultaneously measure the pulse wave and
contact force. .
|4.||Fumiya Nakashima, Ken Yoshinaga, Hirofumi Nogami, and Renshi Sawada, Blood flow measurement for hemodialysis using a miniaturized Laser Doppler velocimeter, 学会, 2017.09, Artificial dialysis circuits are required to measure absolute blood flow noninvasively. A Laser Doppler velocimeter (LDV) can measure absolute velocity in a non-contact manner using laser. Our extremely compact LDV (µ-LDV) could be attached to the wall of a dialysis tube; however, it could not measure absolute velocity when used to measure the blood flow velocity. The authors consider that this is because the concentration of red blood cells in blood is higher than the concentrations commonly used for measurement. In this paper, to study the optical conditions for blood flow measurement, we prepared an optical system with several wavelengths and compared signals by measuring blood and milk flow velocity. Our results show that long wavelength laser is more suitable than short wavelength laser for blood measurement..|
|5.||井ノ上涼, 日暮栄治, 野上大史, 澤田廉士, A New Extremely Small Sensor for Measuring a Blood Flow and a Contact Pressure Simultaneously , 学会, 2018.08, Although a number of laser Doppler blood flow sensors have been developed over the past few decades, they remain uncommon in practice. This is because the contact pressure between the skin and the sensor is not measured simultaneously with blood flow, despite the fact that blood flow is greatly affected by contact pressure. Thus, reliable and highly reproducible measurement of blood flow could not be realized. Therefore, we have developed a micro electro mechanical systems (MEMS) blood flow sensor which has a built-in pressure sensor, for reliable and highly reproducible measurement. .|
|6.||R. Shiraishi, H. Nogami, K. Uchida, M. Nomura, R. Sawada, Developed MEMS blood flow sensor with a built-in pressure sensor and its application to exercise, 学会, 2017.05, Blood flow sensors had been developed for a few decades but not become common so much. It is because contact pressure was not measured simultaneously, though blood flow is greatly affected by the contact pressure between skin and sensor. Reliable and highly reproducible measurement cannot be realized. Therefore, we developed MEMS (micro electro mechanical systems) blood flow sensor with a built-in pressure sensor to achieve reliable and reproducible measurement (Fig. 1). We were able to relate blood flow to contact pressure. As an applications, we measured blood flow with the sensor probe attached to fingertip before, during and after exercise by controlling contact pressure by using the external programmable actuator.
We measured blood flow and contact pressure on fingertip, blood pressure with sphygmomanometer winded on upper arm, and temperature of fingertip simultaneously.
We changed contact pressure from high to low value by programmable actuator with a microcontroller.
As an experimental result, we obtained the followings:
1) High amplitude of blood flow was detected while the contact pressures were changed from high to low value by external actuator. We found that the contact pressure corresponding to the high amplitude is closely related to the blood pressure.
2) The increase of blood flow was higher and more rapidly during exercise than before exercise (Figs. 2 (a) and (b)). The reason for the change is that the blood pressure during exercise was higher than before exercise.
We are planning to detect health information such as dehydration with the developed sensor.
|7.||野上大史、野崎太貴、澤田廉士, Wearable Devices for Healthcare, 1stSino-JapanSeminar on Micro/Nano Systems for Biomedical Applications, 2017.03, For the purpose of increased safety and security, wireless sensor network systems are being used increasingly in applications such as structural health monitoring, human health monitoring, agricultural field monitoring, and animal health monitoring [1–4]. Animal health monitoring system can achieve early detection and prevention of diseases and thus reduce economic losses. The wireless sensor nodes attached to animals, in conjunction with a wireless health-monitoring system, detect initial fever, abnormal activity, or stress level of the animals. In this study, we have focused on developing wireless pulse wave sensor to detect stress levels..|
|8.||野上大史、白石隆太、井ノ上涼、永友 康隆、澤田廉士, Stress monitoring of cow by using pulse wave, BIO4APPS2016, 2016.12, Stress monitoring of cow by using pulse wave.|
|9.||林田優馬、竹下俊弘、野上大史、安藤秀幸、日暮栄治、澤田廉士, Development of Integrated Micro-displacement sensor by embedding amplifier circuits in the chip, BIO4APPS2016, 2016.12, Development of Integrated Micro-displacement sensor by embedding amplifier circuits in the chip.|
|10.||永友 康貴、関口智仁、野上大史、Chengkuo Lee、澤田廉士, NEMS pressure sensor for an integrated laser-doppler blood flowmeter, BIO4APPS2016, 2016.12, NEMS pressure sensor for an integrated laser-doppler blood flowmeter.|
|11.||Lan Zhang、Jian Lu、 Hironao Okada、 Hirofumi Nogami、 Toshihiro Itoh、 Shozo Arai, A Prototype of Solid Type pH Sensor for Real-time Monitoring the Rumen pH Value of Wagyu in Japan, The 7th Japan-China-Korea Joint Conference on MEMS/NEMS2016, 2016.09, We developed a solid thype pH sensor with low power consumption and high accuracy for real-time monitoring of pH value in wagyu rumen..|
|12.||野崎太貴、野上大史、澤田廉士, Development of ultra small VCSEL type MEMS blood flow sensor, The 7th Japan-China-Korea Joint Conference on MEMS/NEMS2016, 2016.09, We developed a sensor device and sensing application technology that can monitor structures such as buildings and bridges, livestock such as cows and chickens, or humans with the aim of building safer and more secure and more comfortable society. This device comprises a laser Doppler blood flow meter that measures peripheral blood flow using micro-electro-mechanical system (MEMS) technology. The system was successful because it was small in size, had low power consumption, and noiselessly sensed blood flow movement. This paper, describes the design and evaluation of our new blood flow sensor, which was constructed using ceramic multilayer technology with the aim of creating a low cost sensor with high signal to noise ratio..|
|13.||関友貴、白石隆太、野上大史、澤田廉士, Rats’ blood flow measurement for detection of dehydration, The Eighth KAIST-Kyushu University Joint Workshop, 2016.09, we use rats for research subjects instead of human, and observe conjugation of rats’ blood flow in dehydration.|
|14.||Fumiya Nakashima, Nobutomo Morita, Hirofumi Nogami, Eiji Higurashi, Renshi Sawada,, Velocity Measurement of Different Concentration Liquids by Micro Laser Doppler Velocimeter, The Eighth KAIST-Kyushu University Joint Workshop, 2016.09, In a field of biomedical, the sensor which can measure suspension liquid flow velocity non-invasively is desired for monitoring or controlling flow rate of liquids such as blood. Laser Doppler velocimeter (LDV) can measure velocity with noncontact for using the laser Doppler effect. However, a LDV is large size and has been used only for research and industry. To solve this problem and apply it to a bio medical field, we have developed an extremely compact LDV (µ-LDV) embeddable into the wall of a tube using MEMS processes (figure 1). However, it is generally difficult for a LDV to measure high concentration liquid such as blood or milk by being caused multiple scattering. Therefore, we measured velocity of the liquids which have different mixed ratio of milk and water in order to find the capability of high concentration liquid measurement. Figure 2 shows the obtained power spectra at the different concentration. The frequency noise from the power supply was observed constantly at 24kHz. The shapes of Doppler signal were significantly different and we need the improvement of an optical system and method of analysis to measure high concentration liquid by using the µ-LDV..|
|15.||井ノ上涼 野上大史 永友康貴 澤田廉士, Use of a pulse wave sensor to detect cow's stress condition for their health care, The 7th Japan-China-Korea Joint Conference on MEMS/NEMS2017, 2016.09, In the stock industry, cowherds have a tendency to raise cattle using large-scale agricultural production to improve productivity. On the other hand, group breeding causes cow’s stress which makes them more susceptible to disease. This may result in growth inhibition or death and thus cause economic loss. Therefore, to improve productivity it is necessary to detect such stressful conditions. When cowherds can identify cows suffering from stress, they can remove them from the group to alleviate stressful conditions. In previous research, we used heartbeat change interval (RRI) measured using a Holter. Using this method, however, it is difficult to measure RRI for more than one week, because shaving and attaching the electrode creates a large burden on the cow. As a result, we developed a wearable pulse wave sensor which can detect RRI without the need to shave and attach an electrode.We fabricated an optical pulse wave sensor to target the base of the tail, which has little hair. In this study, we attached the pulse wave sensor and Holter to a 3-month-old calf and measured its heartrate for five hours. We then calculated RRI and the stress condition value from the apparatus every 30 minutes. We found that the change tendency of the value is similar to conventional methods. There was a high positive correlation (R2=0.8325) between the two. This indicates that our pulse wave sensor was successful in measuring the stress condition of cows. .|
|16.||野上大史、白石隆太、井ノ上涼、澤田廉士, Laser Doppler blood flowmeter for animal health monitoring system, The 7th Japan-China-Korea Joint Conference on MEMS/NEMS2016, 2016.09, The estrus intensity detection of the cow is one of the important purposes for animal health monitoring system. During the time of estrus the engorged vagina can be observed from the outside. The engorged vagina is possible to cause blood flow change. To detect the estrus intensity, we have developed the laser Doppler blood flowmeter sensor element. The sensor element is 3.5 x 5.5 x 1.8mm, which is enable to fabricate wearable wireless sensor node. Using the sensor nodes, we could measure blood flow of the cow in short time. However, measurement of the blood flow was not stable in long term. The cause of the unstable measurement was that the blood flow was sensitive to the contact force between cow’s skin and sensor. The contact force easily changed depending on method of mounting or wagging cow’s tail. In this paper, we incorporated the laser Doppler blood flowmeter sensor element with the force sensor to simultaneously measure the blood flow and the contact force. As a result, we could observe stable measured value of the blood flow and pulse wave at the stable contact pressure. At the unstable contact pressure, the measured value of underwent a lot of changes. In addition, the pulse wave couldn’t be observed. Thus, we propose that the measurement of the blood flow need to correct for the influence of the contact force..|
|17.||白石 隆太, 永友 康貴, 井ノ上 涼, 野上 大史, 澤田 廉士, Investigation of relation between blood flow and contact pressure, The Eighth KAIST-Kyushu University Joint Workshop, 2016.09, To make our society safer and more comfortable, MEMS (Micro Electro Mechanical Systems) technology and its sensors are connecting IoT (Internet of Things) technology tightly. Thanks to this connection, we can measure fatigue of buildings, bridges, and tunnels, detect Parkinson’s disease and sleeping disorder by monitoring our life. Furthermore, we can detect cows’ production disease and pandemic of chickens in early stage by monitoring these animals. In our laboratory, we are developing MEMS Laser Doppler blood flow sensor. Laser Doppler blood flow meter can measure periphery blood flow without invading. We succeeded in realization of electric power saving and miniaturized Laser Doppler blood flow sensor with MEMS technology. By using it, we are measuring blood flow of humans during running, cows and chickens. Change of blood flow is expected when a cow is in stress and feels stress, so we could detect it. However, we can’t get an accurate result of measurement by setting sensor merely because blood flow is varied by contact pressure between skin and sensor. Therefore, we combined Laser Doppler blood flow sensor with contact pressure sensor in order to measure these two values simultaneously. Figure 1 is the structure of our sensor. We can understand the relation between blood flow and contact pressure by using it. We conducted measurement of cow with the sensor. Figure 2 is the result of measurement of two values on cow’s tail. Blood flow is decreasing largely while contact pressure is increasing. We will investigate more the relation between these two values.
|18.||Hirofumi Nogami, Toshihiro Takeshita, M. Hidaka, N. Tokiwa, H. Akiyama, H. Fujii, 澤田 廉士, H. Taguchi, Correlation between the characteristic material properties and the electronic density of band-states & localized microstructure for Ni ions of the micro-filaments made by the LIGA micro-machining (ІІ)
, BIO4APPS2015, 2015.12, We found that the inner resistance of the micro-filaments made by a LIGA micro-machining is more sensitive to the applied actions of light, heat and pressure. .
|19.||野上 大史, Lan Zhang, Jian Lu, Hironao Okada, Toshihiro Itoh, Development of ITO-Based MEMS Sensor for Wagyu-Rumen pH Sensing, BIO4APPS2015, 2015.12, We developed a solid type pH sensor for dairy Wagyu -rumen measurement. The pH sensor is composed by a separate sensing electrode of indium tin oxide (ITO) film and a metal–oxide–semiconductor field-effect transistor (MOSFET)..|
|20.||野上 大史, 三浦 亮太郎, 岡田 宏尚, 前田 龍太郎, 伊藤 寿浩, Wireless temperature sensor nodes in the Appressed Base of a Calf’s tail, BIO4APPS2015, 2015.12.|
|23.||野上 大史, 岡田 宏尚, 宮本 亨, 前田 龍太郎, 伊藤 寿浩, Wearable wireless sensor nodes for an animal health monitoring system, IUMRS-ICA 2014, 2014.08, [URL], To achieve the goal of creating a safer and more secure society, wireless sensor network technology has been a promising approach for a variety of applications, such as structural health monitoring, human body monitoring and animal health monitoring. Animal health monitoring system can achieve early detection and prevention of diseases and thus reduce economic losses. The wireless sensor nodes attached to animals, in conjunction with a wireless health-monitoring system, detect initial fever or abnormal activity of the animals. In this study, we have focused on developing the toughness activity sensors for chickens and the flexible temperature sensors for calves..|