Kyushu University Academic Staff Educational and Research Activities Database
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Taiki Moriyama Last modified date:2019.08.28

Associate Professor / Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University
Department of Endoscopic Diagnostics Therapeutics
Kyushu University Hospital


Undergraduate School
Other Organization


E-Mail
Homepage
http://plaza.umin.ac.jp/endosc/index.html
Department of Diagnostic and Therapeutic Endoscopy, Kyushu University Hospital, Fukuoka, Japan .
http://www.surg1.med.kyushu-u.ac.jp//index.html
Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan .
http://plaza.umin.ac.jp/ovex/
Overseas Exchange Center (OVEX), International Medical Department (iMed), Kyushu University Hospital, Fukuoka, Japan .
http://www.temdec.med.kyushu-u.ac.jp/eng/index.php
Telemedicine Development Center of Asia (TEMDEC), International Medical Department (iMed), Kyushu University Hospital .
Phone
092-642-5856
Fax
092-642-5087
Academic Degree
Ph.D.
Country of degree conferring institution (Overseas)
No
Field of Specialization
Upper gastrointestinal surgery / Endoscopic surgery
Total Priod of education and research career in the foreign country
00years00months
Outline Activities
Activity 1 (Department of Diagnostic and Therapeutic Endoscopy, Vice director): Management of Endoscopy room of Kyushu University Hospital
Activity 2 (Department of Surgery and Oncology): Clinical works (Upper GI surgery, Outpatient, Inpatient), Research works (Presentation for domestic and international conferences, Research articles),
Activity 3 (Overseas Exchange Center, Vice Director):Support for International human exchanges (Inbound and Outbound), Remote Teleconference, Remote Medical Network
Clinical specialty:Upper Gastrointestinal Surgery, Endoscopic Surgery
Research specialty:molecular biology of pancreatic cancer for graduate students
Medical Education:Lecture for Gastroenterological Surgery and International Medical Education
Research
Research Interests
  • Clinical research for gastric cancer and esophageal cancer
    Minimally invasive surgery
    keyword : Gastric cancer, Esophageal cancer, Minimally invasive surgery
    2014.05.
  • tumor-stromal interaction of pancreatic cancer, microRNA
    keyword : pancreatic cancer, stromal cell, microRNA
    2006.04.
Academic Activities
Papers
1. Moriyama T, Ohuchida K, Mizumoto K, Cui L, Ikenaga N, Sato N, Tanaka M, Enhanced cell migration and invasion of CD133+ pancreatic cancer cells cocultured with pancreatic stromal cells, Cancer, 116, 14, 3357-3368, 2010.04, BACKGROUND: Recently, cancer stem cells have been reported as a new therapeutic target in pancreatic cancer as well as other cancers, but the specific role of these cells is unknown. METHODS: The authors investigated the functional roles of CD133+ cells, 1 of the putative cancer stem cell candidates in pancreatic cancer. CD133 expression was assessed in human pancreatic cancer and cancer cell lines by quantitative real-time reverse transcriptase polymerase chain reaction and flow cytometry. Next, they compared the ability of CD133+ and CD133- cells to proliferate, migrate, and invade using 2 pancreatic cancer cell lines. In particular, they evaluated the relationship between CD133+ cells and primary pancreatic stromal cells. RESULTS: CD133 was expressed in primary human pancreatic cancer tissues and some cancer cell lines, whereas there was little expression in primary normal pancreatic epithelial cells and primary pancreatic stromal cells. CD133+ cells, isolated by flow cytometry, showed increased cell proliferation under anchorage-independent conditions (P<.01), and enhanced migration and invasion, particularly when cocultured with primary pancreatic stromal cells (P<.001). Chemokine-related receptor-4 (CXCR4), markedly overexpressed in CD133+ cells, may be responsible for the increased invasive ability of the cells cocultured with pancreatic stromal cells, which express stromal derived factor-1, the ligand to CXCR4. CONCLUSIONS: These data suggest that CD133+ cells exhibit more aggressive behavior, such as increased cell proliferation, migration, and invasion, especially in the presence of pancreatic stromal cells. The targeting therapy for the interaction between CD133+ cancer cells and stromal cells may be a new approach for the treatment of pancreatic cancer. Copyright (c) 2010 American Cancer Society..
2. Moriyama T, Ohuchida K, Mizumoto K, Yu J, Sato N, Nabae T, Takahata S, Toma H, Nagai E, Tanaka M, MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance., Mol Cancer Ther, 8, 5, 1067-1074, 2009.04, Abstract

Due to the poor prognosis of pancreatic cancer, novel diagnostic modalities for early diagnosis and new therapeutic strategy are urgently needed. Recently, microRNA-21 (miR-21) was reported to be strongly overexpressed in pancreatic cancer as well as in other solid cancers. We investigated the functional roles of miR-21, which have not been fully elucidated in pancreatic cancer. miR-21 expression was assessed in pancreatic cancer cell lines (14 cancer cell lines, primary cultures of normal pancreatic epithelial cells and fibroblasts, and a human normal pancreatic ductal epithelial cell line) and pancreatic tissue samples (25 cancer tissues and 25 normal tissues) by quantitative real-time reverse transcription-PCR amplification. Moreover, we investigated the proliferation, invasion, and chemoresistance of pancreatic cancer cells transfected with miR-21 precursor or inhibitor. miR-21 was markedly overexpressed in pancreatic cancer cells compared with nonmalignant cells, and miR-21 in cancer tissues was much higher than in nonmalignant tissues. The cancer cells transfected with the miR-21 precursor showed significantly increased proliferation, Matrigel invasion, and chemoresistance for gemcitabine compared with the control cells. In contrast, inhibition of miR-21 decreased proliferation, Matrigel invasion, and chemoresistance for gemcitabine. Moreover, miR-21 positively correlated with the mRNA expression of invasion-related genes, matrix metalloproteinase-2 and -9, and vascular endothelial growth factor. These data suggest that miR-21 expression is increased in pancreatic cancer cells and that miR-21 contributes to the cell proliferation, invasion, and chemoresistance of pancreatic cancer..
3. Moriyama T, Yamashita H, Noguchi S, Takamatsu Y, Ogawa T, Watanabe S, Uchino S, Ohshima A, Kuroki S, Tanaka M, Intraoperative Parathyroid Hormone Assay in Patients with Graves' Disease for Prediction of Postoperative Tetany, World J. Surg., 29, 10, 1282-1287, 2005.04, We measured intraoperative parathyroid hormone (IOPTH) levels before and after thyroidectomy in a large group of patients to test whether changes in IOPTH can predict postoperative tetany. Subjects were 111 consecutive patients (94 females and 17 males) with Graves' disease undergoing subtotal thyroidectomy. Blood samples for IOPTH assay were obtained after anesthesia (basal) and following skin closure (postoperative). Data were compared between patients who developed tetany (n = 9) and those who did not (n = 102). There was no significant difference in sex, age, period of antithyroid drug administration, or the weight of the thyroid between the two groups. The preoperative serum calcium level was significantly lower (p < 0.05) and the basal IOPTH significantly higher (p < 0.05) in the tetany group than in the non-tetany group. The IOPTH level was significantly lower (p < 0.005) and the average percent decrease in IOPTH levels was higher (p < 0.001) in the tetany group than in the non-tetany group. A decrease in IOPTH of more than 70% was shown to be 78% sensitive, 94% specific, and 93% accurate, and it has 78% positive predictive value and 94% negative predictive value for the development of tetany. Our study shows that a postoperative decrease of IOPTH level is the most predictive of postoperative tetany of the clinical risk factors investigated. We recommend IOPTH measurement as an adjunct to postoperative management of patients with Graves' disease to assist in preventing hypocalcemia and determining the earliest time for safe discharge..
Membership in Academic Society
  • Japan Surgical Society
  • The Japanese Society of Gastroenterological Surgery (JSGS)
  • Japan Society for Endoscopic Surgery (JSES)
  • Japan Society of Clinical Oncology (JSCO)
  • Japanese Gastric Cancer Association
  • Japanese Esophageal Society
  • Japan Association of Endocrine Surgeons
  • Japanese Breast Cancer Society
  • Japanese Telemedicine and Telecare Association
  • Japan Gastroenterological Endoscopy Society (JGES)
Educational
Educational Activities
Medical Education:Lecture for Gastroenterological Surgery and International Medical Education
Social
Professional and Outreach Activities
Oversea exchange center:Visiting hospitals in foreign countries, Attending International Meetings
TEMDEC:Establish effective and consistent medical communications among Asian countries using super-fast Internet and advanced technology.
Surgery 1:International exchanges among medical staff, such as overseas training and visits from foreign medical staff and researchers..