| 1. |
金谷啓之、伊藤太一, 刺胞動物を用いた概日リズム・睡眠研究, 日本時間生物学会学会誌, 2022.11. |
| 2. |
金谷啓之、伊藤太一, ヒドラが解き明かす睡眠の進化的起源, 実験医学, 羊土社, 2022.06. |
| 3. |
伊藤太一, 脳のないヒドラを用いた睡眠研究--睡眠現象をよりシンプルに理解する, 医学のあゆみ, 2022.01. |
| 4. |
伊藤太一, 行動睡眠メカニズム研究のモデルとしてのヒドラの有用性, バイオインダストリー協会(JBA)「バイオサイエンスとインダストリー(B&I)」, 2021.05. |
| 5. |
佐藤文, 金谷啓之, 伊藤太一, 動物はいつから眠るようになったのか？ – 脳のないヒドラから睡眠の起源を探る, academist Journal, 2020.12. |
| 6. |
Jongbo Lee, Minjong Kim, Taichi Q Itoh, Chunghun Lim, Ataxin-2: A versatile posttranscriptional regulator and its implication in neural function., Wiley interdisciplinary reviews. RNA, 10.1002/wrna.1488, Vol.9, No.6, p.e1488, 2018.11, Ataxin-2 (ATXN2) is a eukaryotic RNA-binding protein that is conserved from yeast to human. Genetic expansion of a poly-glutamine tract in human ATXN2 has been implicated in several neurodegenerative diseases, likely acting through gain-of-function effects. Emerging evidence, however, suggests that ATXN2 plays more direct roles in neural function via specific molecular and cellular pathways. ATXN2 and its associated protein complex control distinct steps in posttranscriptional gene expression, including poly-A tailing, RNA stabilization, microRNA-dependent gene silencing, and translational activation. Specific RNA substrates have been identified for the functions of ATXN2 in aspects of neural physiology, such as circadian rhythms and olfactory habituation. Genetic models of ATXN2 loss-of-function have further revealed its significance in stress-induced cytoplasmic granules, mechanistic target of rapamycin signaling, and cellular metabolism, all of which are crucial for neural homeostasis. Accordingly, we propose that molecular evolution has been selecting the ATXN2 protein complex as an important trans-acting module for the posttranscriptional control of diverse neural functions. This explains how ATXN2 intimately interacts with various neurodegenerative disease genes, and suggests that loss-of-function effects of ATXN2 could be therapeutic targets for ATXN2-related neurological disorders. This article is categorized under: RNA in Disease and Development > RNA in Disease RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications.. |
| 7. |
内園駿, 伊藤太一, アミノ酸はいつ必要？ – ショウジョウバエのメスは交尾後の夜にアミノ酸を多く摂取する, academist Journal, 2017.03. |
| 8. |
伊藤太一, アメリカNorthwestern大学でのポスドク生活, 時間生物学, Vol.22, No.2, pp.65-68, 2016.11. |
| 9. |
Tomas S. Andreani, Taichi Q. Itoh, Evrim Yildirim, Dae-Sung Hwangbo, Ravi Allada, Genetics of Circadian Rhythms, 10.1016/j.jsmc.2015.08.007, Vol.10, No.4, pp.413-421, 2015.12. |
| 10. |
伊藤太一, 松本顕, ショウジョウバエを用いた概日測時機構解析の40年-第2部 ショウジョウバエ再び-, 時間生物学, Vol.19, No.2, pp.70-78, 2013.10. |
| 11. |
伊藤太一, 松本顕, ショウジョウバエを用いた概日測時機構解析の40年-第1部 ショウジョウバエは再びとべるか?-, 時間生物学, Vol.19, No.1, pp.17-25, 2013.06. |
