キーワード：ソフトウェア工学, 記述言語, 数値計算
|嶋吉 隆夫（しまよし たかお）||データ更新日：2019.05.09|
キーワード：心臓, 心室, 血管系, 細胞生理学, 電気生理学, 構造力学
キーワード：心臓, 心室, 血管系, 細胞生理学, 電気生理学, 構造力学
|1.||Yuki Hasegawa, Takao Shimayoshi, Akira Amano, Tetsuya Matsuda, Application of the Kalman Filter for Faster Strong Coupling of Cardiovascular Simulations, IEEE Journal of Biomedical and Health Informatics, 10.1109/JBHI.2015.2436212, 20, 4, 1100-1106, 2016.07, [URL], In this paper, we propose a method for reducing the computational cost of strong coupling for multiscale cardiovascular simulation models. In such a model, individual model modules of myocardial cell, left ventricular structural dynamics, and circulatory hemodynamics are coupled. The strong coupling method enables stable and accurate calculation, but requires iterative calculations which are computationally expensive. The iterative calculations can be reduced, if accurate initial approximations are made available by predictors. The proposed method uses the Kalman filter to estimate accurate predictions by filtering out noise included in past values. The performance of the proposed method was assessed with an application to a previously published multiscale cardiovascular model. The proposed method reduced the number of iterations by 90% and 62% compared with no prediction and Lagrange extrapolation, respectively. Even when the parameters were varied and number of elements of the left ventricular finite-element model increased, the number of iterations required by the proposed method was significantly lower than that without prediction. These results indicate the robustness, scalability, and validity of the proposed method..|
|2.||Yukari Takeda, Takao Shimayoshi, George G. Holz, Akinori Noma, Modeling analysis of inositol 1,4,5-trisphosphate receptor-mediated ca2+ mobilization under the control of glucagon-like peptide-1 in mouse pancreatic β-cells, American Journal of Physiology - Cell Physiology, 10.1152/ajpcell.00234.2015, 310, 5, C337-C347, 2016.03, [URL], Glucagon-like peptide-1 (GLP-1) is an intestinally derived blood glucose-lowering hormone that potentiates glucose-stimulated insulin secretion from pancreatic β-cells. The secretagogue action of GLP-1 is explained, at least in part, by its ability to stimulate cAMP production so that cAMP may facilitate the release of Ca2+from inositol trisphosphate receptor (IP3R)-regulated Ca2+ stores. However, a quantitative model has yet to be provided that explains the molecular mechanisms and dynamic processes linking GLP-1-stimulated cAMP production to Ca2+ mobilization. Here, we performed simulation studies to investigate how GLP-1 alters the abilities of Ca2+ and IP3 to act as coagonists at IP3R Ca2+ release channels. A new dynamic model was constructed based on the Kaftan model, which demonstrates dual steady-state allosteric regulation of the IP3R by Ca2+ and IP3. Data obtained from β-cells were then analyzed to understand how GLP-1 facilitates IP3R-mediated Ca2+ mobilization when UV flash photolysis is used to uncage Ca2+ and IP3 intracellularly. When the dynamic model for IP3R activation was incorporated into a minimal cell model, the Ca2+ transients and oscillations induced by GLP-1 were successfully reconstructed. Simulation studies indicated that transient and oscillatory responses to GLP-1 were produced by sequential positive and negative feedback regulation due to fast activation and slow inhibition of the IP3R by Ca2+. The slow rate of Ca2+ -dependent inhibition was revealed to provide a remarkable contribution to the time course of the decay of cytosolic Ca2+ transients. It also served to drive and pace Ca2+ oscillations that are significant when evaluating how GLP-1 stimulates insulin secretion..|
|3.||Takao Shimayoshi, Chae Young Cha, Akira Amano, Quantitative Decomposition of Dynamics of Mathematical Cell Models: Method and Application to Ventricular Myocyte Models, PLOS ONE, 10.1371/journal.pone.0124970, 10, 6, 2015.06.|
主要総説, 論評, 解説, 書評, 報告書等
優秀論文賞, マルチメディア，分散協調とモバイルシンポジウム2018, 2018.09.
生体医工学シンポジウム2016ポスターアワード, 生体医工学シンポジウム2016, 2016.09.