Kyushu University Academic Staff Educational and Research Activities Database
Researcher information (To researchers) Need Help? How to update
Yukiko Ogino Last modified date:2019.06.10

Undergraduate School
Other Organization

Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
Endocrinology, Evolutionary Biology, Environmental Science
Total Priod of education and research career in the foreign country
Outline Activities
Education: I am in charge of the classes regarding the Ecology and Evolutionary Biology in IUPE general education courses.
Research: My research is focused on the molecular basis of androgen-dependent sex characteristics development and evolution, which brings the morphological specification of male type sex attractive and reproductive organs, and the wide variety of reproductive strategies in vertebrates.
Research Interests
  • Analysis of chromatin dynamics during the sex characteristics development
    keyword : androgen receptor
  • Analysis of the relation between sex characteristics development and the individual recognition, the emotional control system using fish as model animal
    keyword : environment, endocrine system, stress
  • Molecular basis of androgen-dependent sex characteristics development and evolution
    Generation of bio-monitoring medaka
    keyword : androgen, sex characteristics, morphological diversification, genome duplication, endocrine disruptors
Academic Activities
1. Yukiko Ogino, Shigehiro Kuraku, Hiroshi Ishibashi, Hitoshi Miyakawa, Eri Sumiya, Shinichi Miyagawa, Hajime Matsubara, Gen yamada, Michael E. Baker, Taisen Iguchi, Neofunctionalization of androgen receptor by gain-of-function mutations in teleost fish lineage, Molecular Biology and Evolution, 33, 228-244, 2016.01.
2. Yukiko Ogino, Ikumi Hirakawa, Keiji Inohaya, Eri Sumiya, Shinichi Miyagawa, Nancy Denslow, Gen Yamada, Norihisa Tatarazako, Taisen Iguchi, Bmp7 and Lef1 are the down stream effectors of androgen signaling in androgen-induced sex characteristics development in medaka, Endocrinology, 155, 449-462, 2014.02.
3. Yukiko Ogino, Shinichi Miyagawa, Hironori Katoh, Gail S. Prins, Taisen Iguchi, Gen Yamada, Essential functions of androgen signaling emerged through the developmental analysis of vertebrate sex characteristics, Evolution and Development, 13, 315-325, 2011.05.
4. Yukiko Ogino, Hironori Katoh, Shigehiro Kuraku, Gen Yamada, Evolutionary history and functional characterization of androgen receptor genes in jawed vertebrates, Endocrinology, 150, 5415-5427, 2009.12.
1. Yukiko Ogino, Hirotaka Sakamoto, Eiji Watanabe and Taisen Iguchi, Diversification of androgen receptor function underlies secondary sex characteristics development of teleost fishes. , 4th Strategic Meeting for Medaka Research,3rd Regional Fish Meeting, 2018.04, Gene duplication is a dominant driving force of evolution. Steroid hormone receptor gene family is thought to have arisen from gene duplication. However, the molecular events which produce new protein functions after the genome duplication have not been fully understood. Teleost fishes present a good model to investigate an accurate evolutionary history of protein function after whole genome duplication, because the teleost-specific whole genome duplication (TSGD) 350 million years ago resulted in a variety of duplicated genes that exist in modern fishes. We focused on the androgen receptor (AR) gene, since two different subtype genes, AR and AR, were generated in the TSGD. AR has retained the ancestral function, whereas the AR evolved as a hyperactive form of AR in the teleost lineage. Results of our combined functional and 3 dimensional analyses of medaka (Oryzias latipes) ARs identified the substitutions that led to changes in protein structure and function between medaka AR and AR. One substitution located within the helices 10/11 of ligand binding domain is sufficient for generating higher transactivation of AR. This amino acid change affects the stability of ligand binding by modifying the hydrogen bonds between ligand and AR.
To further address the functional differences between AR and AR in vivo, we isolated the nonsense mutants of AR and AR from the medaka tilling library. AR have predominant function for external masculine phenotypes, and AR might participate the development of traits for male-male competition. Our findings would provide an historical explanation for the retention of the duplicated AR copies in euteleost genome..
2. 荻野 由紀子, 井口泰泉, Evolutionary diversification of androgen dependent sex characteristics development in teleost fishes., The 22nd International Congress of Zoology, 2016.11.
3. 荻野 由紀子, Functional and evolutionary analyses of androgen receptor gene in teleost fishes: Molecular basis of diversified sex characteristics development, 小型魚類研究会, 2016.08.
Membership in Academic Society
  • The Social Brain: Social Neural Networks Research Unit
  • Japan Society for Comparative Endocrinology
  • The Japanese Biochemical Society
  • Japanese Society of Scientific Fisheries
  • The Molecular Biology Society of Japan
  • Japan Society of Endocrine Disrupter Research
  • Japanese society of developmental biologists
  • Zoological Society of Japan
Educational Activities
To develop the ability of the creative thinking that is necessary to solve the global environmental problem, I teach the wide variety of biological research areas of biological sciences, such as ecology, environmental science, evolutionary biology, and molecular biology.
Other Educational Activities
  • 2017.05, I am in charge of the classes regarding the ecology, evolutionary biology iin IUPE general education courses. Student can widely learn the mechanism of biodiversity from the scopes of ecology, evolutionary biology, and environmental science..