Kyushu University Academic Staff Educational and Research Activities Database
Researcher information (To researchers) Need Help? How to update
Yoji Andrew MINAMISHIMA Last modified date:2017.07.21





E-Mail
Homepage
http://www.bioreg.kyushu-u.ac.jp/saibou/member1_en.html
Division of Cell Biology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University .
http://www.oxygenbiology.net/
Grant-in-Aid for Scientific Research on Innovative Areas "Oxygen Biology: A New Criterion of Integrated Understanding of Life" .
http://www.jst.go.jp/erato/suematsu/eng-sgbpro/contents/eng-member.html
Suematsu Gas Biology Project, ERATO, Japan Science and Technology Agency (JST) .
http://researchers.dana-farber.org/directory/profile.asp?pict_id=0000026&gs=r
Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Harvard Medical School .
http://orcid.org/0000-0001-7995-9318
ORCID .
https://www.scopus.com/authid/detail.uri?authorId=17346351400
Scopus .
http://researchmap.jp/minamishima/
Researchmap, JST .
http://www.researcherid.com/rid/E-5380-2010
ResearcheID .
http://1.usa.gov/1FP8ywi
PubMed .
https://publons.com/a/489610/
Publons .
Academic Degree
Ph.D. in Medical Sciences
Field of Specialization
hypoxic response, metabolism, tumor biology
Research
Research Interests
  • Hypoxic response, Tumor metabolism
    keyword : Hypoxic response, Tumor metabolism
    2016.04.
Academic Activities
Books
1. , [URL].
2. , [URL].
Papers
1. Oyaizu–Toramaru T, Suhara T, Hayakawa N, Nakamura T, Kubo A, Minamishima S, Yamaguchi K, Hishiki T, Morisaki H, Suematsu M, Minamishima YA, Targeting oxygen sensing prolyl hydroxylase (PHD) for metformin-associated lactic acidosis treatment, Mol Cell Biol, 2017.06.
2. Suhara T, Hishiki T, Kasahara M, Hayakawa N, Oyaizu T, Nakanishi T, Kubo A, Morisaki H, Kaelin WG Jr, Suematsu M, Minamishima YA, Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle, Proc Natl Acad Sci U S A. , 112, 37, 2015.09.
3. Bao Y, Mukai K, Hishiki T, Kubo A, Ohmura M, Sugiura Y, Matsuura T, Nagahata Y, Hayakawa N, Yamamoto T, Fukuda R, Saya H, Suematsu M, Minamishima YA, Energy management by enhanced glycolysis in G1 phase in human colon cancer cells in vivo and in vitro, Mol Cancer Res, 11, 9, 2013.09.
4. Moslehi J*, Minamishima YA*, Shi J, Neuberg D, Charytan DM, Padera RF, Signoretti S, Liao R, Kaelin WG Jr. (*Equally contributed), Loss of Hypoxia-Inducible Factor Prolyl Hydroxylase Activity in Cardiomyocytes Phenocopies Ischemic Cardiomyopathy, Circulation, 122, 10, 2010.09.
5. Minamishima YA and Kaelin WG Jr, Reactivation of Hepatic EPO Synthesis in Mice after PHD Loss, Science, 329, 990, 2010.07.
6. Minamishima YA, Moslehi J, Bardeesy N, Cullen D, Bronson RT, Kaelin WG Jr, Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure, Blood, 111, 6, 2009.03.
7. Young AP, Schlisio S, Minamishima YA, Zhang Q, Li L, Grisanzio C, Signoretti S, Kaelin WG Jr, VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400, Nat Cell Biol, 10, 3, 2009.03.
8. Yang H, Minamishima YA, Yan Q, Schlisio S, Ebert BL, Zhang X, Zhang L, Kim WY, Olumi AF, Kaelin WG Jr, pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2, Mol Cell, 28, 1, 2007.10.
9. Nakayama K, Nagahama H, Minamishima YA, Miyake S, Ishida N, Hatakeyama S, Kitagawa M, Iemura S, Natsume T, Nakayama KI, Skp2-mediated degradation of p27 regulates progression into mitosis, Dev Cell, 6, 5, 2004.05.
10. Minamishima YA, Nakayama K, Nakayama K, Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice, Cancer Res, 62, 4, 2002.02.
11. Nakayama K, Nagahama H, Minamishima YA, Matsumoto M, Nakamichi I, Kitagawa K, Shirane M, Tsunematsu R, Tsukiyama T, Ishida N, Kitagawa M, Nakayama K, Hatakeyama S, Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication, EMBO J, 19, 9, 2000.05.
Presentations
1. Tomoko Oyaizu-Toramaru, Tomohiro Suhara, Noriyo Hayakawa, Takashi Nakamura, Shizuka Minamishima, Akiko Kubo, Kyoji Yamaguchi, Takako Hishiki, Hiroshi Morisaki, Makoto Suematsu, Yoji Andrew Minamishima, Targeting the oxygen sensor PHD (prolyl hydroxylase) for the treatment of lethal lactic acidosis, 第90回日本薬理学会年会, 2017.03.16, [URL].
2. Shotaro Kishimoto, Noriyo Hayakawa, Makoto Suematsu, Yoji Andrew Minamishima, Glycosaminoglycan as an energy source for pancreatic cancer cells: A novel potential therapeutic target, 第75回日本癌学会総会, 2016.10.07.
3. Tomoko Oyaizu-Toramaru, Tomohiro Suhara, Noriyo Hayakawa, Takashi Nakamura, Shizuka Minamishima, Kyoji Yamaguchi, Takako Hishiki, Hiroshi Morisaki, Makoto Suematsu, Yoji Andrew Minamishima, Targeting hypoxic response for the treatment of diseases: Renal anemia and lethal lactic acidosis, 第89回日本生化学会大会, 2016.09.26.
Membership in Academic Society
  • Physiology Society of Japan
  • The Japanese Pharmacological Society
  • The Molecular Biology Society of Japan
  • The Japanese Biochemical Society
  • Japan Cancer Association
Awards
  • Targeting the oxygen sensor PHD (prolyl hydroxylase) for the treatment of lethal lactic acidosis