Kyushu University [Yoshikazu Kikuchi (Assistant Professor) Kyushu University Hospital, Otorhinolaryngology Head and Neck Surgery]

Yoshikazu Kikuchi

Last modified date：2024.04.15

Assistant Professor / Departments of Otorhinolaryngology, Graduate School of Medical Sciences / Otorhinolaryngology Head and Neck Surgery / Kyushu University Hospital

Papers

1.	Kikuchi, Y, Kenjo, M, Yoshida, E, Takahashi, S, Murakami, D, Yamaguchi, Y, Adachi K, Sawatsubashi M, Taura M, Nakagawa T, Umezaki T. , Social anxiety disorder in adolescents who stutter: A risk for school refusal. , Pediatr Int. , 65, e15622, 2023.09.
2.	Kikuchi Y, Umezaki T, Adachi K, Sawatsubashi M, Taura M, Yamaguchi Y, Tsuchihashi N, Murakami D, Nakagawa T. , Employment Quotas for Adults who Stutter: A Preliminary Study., Int Arch Commun Disord , doi.org/10.23937/2643-4148/1710020, 4:020. , 2022.05.
3.	Kikuchi Y, Umezaki T, Adachi K, Sawatsubashi M, Taura M, Yamaguchi Y, Fukui K, Tsuchihashi N, Murakami D, Nakagawa T. , Can having siblings increase stuttering as compared to being an only child?. , Int Arch Commun Disord, doi.org/10.23937/2643-4148/1710017, 3:017, 2020.11, [URL].
4.	Kikuchi Y, Umezaki T, Adachi K, Sawatsubashi M, Taura M, Yamaguchi Y, Tsuchihashi N, Murakami D, Nakagawa T., Age at Decannulation after Pediatric Tracheostomy., J ENT Care Otolaryngol Res., 2: 1006, 2020.11, [URL].
5.	Kazuo Adachi, Toshiro Umezaki, Naoko Matsubara, Yogaku Lee, Takashi Inoguchi, Yoshikazu Kikuchi, Tracheoesophageal diversion improves oral uptake of food a retrospective study, European Archives of Oto-Rhino-Laryngology, 10.1007/s00405-020-05988-8, 2020.01, Purpose: Tracheoesophageal diversion (TED) is an effective therapeutic procedure for intractable aspiration. In this study, we performed TED in cases of intractable aspiration and/or repetitive pneumonia, investigated the main route of nutritional uptake after the procedure, and evaluated the swallowing method using videofluoroscopy. We also evaluated the validity of TED for treating intractable aspiration. Methods: We retrospectively reviewed 44 patients (30 male and 14 female patients; median age, 55 years; range 15–85 years) who underwent TED for the treatment of intractable aspiration between January 2008 and December 2017. We examined the route of nutritional uptake before and after the operation and performed videofluoroscopy to detect the swallowing method after the operation. Results: The percentage of patients with oral intake increased from 21% (9/44) before TED to 56% (25/44) within 1 month after TED (p
6.	Kikuchi Y, Umezaki T, Adachi K, Sawatsubashi M, Taura M, Yamaguchi Y, Tsuchihashi N, Murakami D, Nakagawa T. , Awareness in young stuttering Japanese children aged 3-7 years. , Pediatr Int. , doi: 10.1111/ped.14405. , 2020.07.
7.	Kikuchi Y, Umezaki T, Sawatsubashi M, Taura M, Yamaguchi Y, Murakami D, Nakagawa T., Experiences of teasing and bullying in children who stutter., Int Arch Commun Disord, doi:10.23937/2643-4148., 2, 013, 2019.12.
8.	Hayato Une, Dai Matsuse, Taira Uehara, Yoshikazu Kikuchi, Saeko Inamizu, Ryo Yamasaki, Shozo Tobimatsu, Hiroshi Shibasaki, Jun ichi Kira, Branchial myorhythmia in a case of systemic lupus erythematosus, Journal of the Neurological Sciences, 10.1016/j.jns.2019.116501, 408, 2020.01.
9.	Teppei Matsubara, Katsuya Ogata, Naruhito Hironaga, Yosikazu Kikuchi, Taira Uehara, Hiroshi Chatani, Takako Mitsudo, Hiroshi Shigeto, Shozo Tobimatsu, Altered neural synchronization to pure tone stimulation in patients with mesial temporal lobe epilepsy An MEG study, Epilepsy and Behavior, 10.1016/j.yebeh.2018.08.036, 88, 96-105, 2018.11, Objective: Our previous study of monaural auditory evoked magnetic fields (AEFs) demonstrated that hippocampal sclerosis significantly modulated auditory processing in patients with mesial temporal lobe epilepsy (mTLE). However, the small sample size (n = 17) and focus on the M100 response were insufficient to elucidate the lateralization of the epileptic focus. Therefore, we increased the number of patients with mTLE (n = 39) to examine whether neural synchronization induced by monaural pure tone stimulation provides useful diagnostic information about epileptic foci in patients with unilateral mTLE. Methods: Twenty-five patients with left mTLE, 14 patients with right mTLE, and 32 healthy controls (HCs) were recruited. Auditory stimuli of 500-Hz tone burst were monaurally presented to subjects. The AEF data were analyzed with source estimation of M100 responses in bilateral auditory cortices (ACs). Neural synchronization within ACs and between ACs was evaluated with phase-locking factor (PLF) and phase-locking value (PLV), respectively. Linear discriminant analysis was performed for diagnosis and lateralization of epileptic focus. Results: The M100 amplitude revealed that patients with right mTLE exhibited smaller M100 amplitude than patients with left mTLE and HCs. Interestingly, PLF was able to differentiate the groups with mTLE, with decreased PLFs in the alpha band observed in patients with right mTLE compared with those (PLFs) in patients with left mTLE. Right hemispheric predominance was confirmed in both HCs and patients with left mTLE while patients with right mTLE showed a lack of right hemispheric predominance. Functional connectivity between bilateral ACs (PLV) was reduced in both patients with right and left mTLE compared with that of HCs. The accuracy of diagnosis and lateralization was 80%–90%. Conclusion: Auditory cortex subnormal function was more pronounced in patients with right mTLE compared with that in patients with left mTLE as well as HCs. Monaural AEFs can be used to reveal the pathophysiology of mTLE. Overall, our results indicate that altered neural synchronization may provide useful information about possible functional deterioration in patients with unilateral mTLE..
10.	Hideyuki Kiyohara, Kazuo Adachi, Yosikazu Kikuchi, Ryutaro Uchi, Motohiro Sawatsubashi, Takashi Nakagawa, Kinematic evaluation of penetration and aspiration in laryngeal elevating and descending periods, Laryngoscope, 10.1002/lary.26844, 128, 4, 806-811, 2018.04, Objectives: It is important to evaluate swallowing movements by dividing them into periods of laryngeal closure and release. The purpose of this study was to evaluate penetration–aspiration (PA) according to human pathophysiology and to identify the factors for predicting PA. Study Design: Case-control study. Methods: Eighty-one patients with complaints of dysphagia caused by various etiologies were enrolled in this study. Videofluoroscopic swallowing studies were conducted, and the spatial and temporal factors were analyzed by computer-assisted motion analysis. Results: The initiation of laryngeal vestibule closure in the laryngeal elevating period and its duration in the laryngeal descending period were significant factors for evaluating PA. Conclusion: A knowledge of the delay of laryngeal vestibule closure in the laryngeal elevating period and its short duration in the laryngeal descending period could make it easier to evaluate the risk of PA. Level of Evidence: 3b. Laryngoscope, 128:806–811, 2018..
11.	Kikuchi Y, Umezaki T, Adachi K, Sawatsubashi M, Yamaguchi Y, Murakami D, Nakagawa T., Evaluation of vocal fold motion during blocks in adults who stutter. , Int Arch Commun Disord, doi.org/10.23937/iacod-2017/1710006 ., 1, 6, 1-5, 2018.04.
12.	Yoshikazu Kikuchi, Toshiro Umezaki, Taira Uehara, Hiroo Yamaguchi, Koji Yamashita, Hiwatashi Akio, Sawatsubashi M, Yumi Yamaguchi, Daisuke Murakami, Jun-ichi Kira, Takashi Nakagawa, A case of multiple system atrophy-parkinsonian type with stuttering- and palilalia-like dysfluencies and putaminal atrophy., J Fluency Disord, 10.1016/j.jfludis.2017.11.002, 2017.11.
13.	Kazuo Adachi, Toshiro Umezaki, Yosikazu Kikuchi, Videoendoscopy worsens swallowing function a videofluoroscopic study. A randomized controlled trial, European Archives of Oto-Rhino-Laryngology, 10.1007/s00405-017-4720-7, 274, 10, 3729-3734, 2017.10, Aspiration pneumonia is a cause of mortality in the elderly. Evaluating swallowing function is important. Videofluoroscopy and flexible endoscopic evaluation of swallowing are comparable; however, observing all swallowing dynamics is impossible using the latter approach. We examined the significance of flexible endoscopic evaluation of swallowing using videofluoroscopy. Thirty-seven patients with dysphagia [70.0 ± 8.9 (range 49–84) years] were included. In random order, patients underwent videofluoroscopy with 10 cc contrast material, once without, and once with an endoscope inserted. Laryngeal elevation delay time, Penetration–Aspiration Scale score, and Pharyngeal Residue Severity Rating Scale score were evaluated. Laryngeal elevation delay time without or with endoscope insertion was similar (0.35 ± 0.16 s vs. 0.36 ± 0.16 s, P = 0.29). The Penetration–Aspiration Scale (3.59 ± 2.71 vs. 4.41 ± 2.85; P
14.	Yosikazu Kikuchi, Tsuyoshi Okamoto, Katsuya Ogata, Koichi Hagiwara, Toshiro Umezaki, Masamutsu Kenjo, Takashi Nakagawa, Shozo Tobimatsu, Abnormal auditory synchronization in stuttering A magnetoencephalographic study, Hearing Research, 10.1016/j.heares.2016.10.027, 344, 82-89, 2017.01, In a previous magnetoencephalographic study, we showed both functional and structural reorganization of the right auditory cortex and impaired left auditory cortex function in people who stutter (PWS). In the present work, we reevaluated the same dataset to further investigate how the right and left auditory cortices interact to compensate for stuttering. We evaluated bilateral N100m latencies as well as indices of local and inter-hemispheric phase synchronization of the auditory cortices. The left N100m latency was significantly prolonged relative to the right N100m latency in PWS, while healthy control participants did not show any inter-hemispheric differences in latency. A phase-locking factor (PLF) analysis, which indicates the degree of local phase synchronization, demonstrated enhanced alpha-band synchrony in the right auditory area of PWS. A phase-locking value (PLV) analysis of inter-hemispheric synchronization demonstrated significant elevations in the beta band between the right and left auditory cortices in PWS. In addition, right PLF and PLVs were positively correlated with stuttering frequency in PWS. Taken together, our data suggest that increased right hemispheric local phase synchronization and increased inter-hemispheric phase synchronization are electrophysiological correlates of a compensatory mechanism for impaired left auditory processing in PWS..

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