| Yoichiro Kuninobu | Last modified date：2024.04.19 |
Professor /
Department of Fundamental Organic Chemistry /
Institute for Materials Chemistry and Engineering
Reports
| 1. | Kuninobu, Y.*, Non-covalent Interaction-Controlled Site-selective C–H Transformations, Chem. Rec., 10.1002/tcr.202300149, 2023.09, [URL]. |
| 2. | Kuninobu, Y.*, Regioselective C–H Trifluoromethylation and Its Related Reactions of (Hetero)aromatic Compounds, Chem. Rec., 10.1002/tcr.202300003, 2023.09, [URL]. |
| 3. | Kuninobu, Y.*; Torigoe, T., Regioselective C-H Trifluoromethylation of Heteroaromatic Compounds., Bull. Chem. Soc. Jpn., 10.1246/bcsj.20200302, 2021.02, [URL]. |
| 4. | , [URL]. |
| 5. | Yoichiro Kuninobu, Development of Novel C-H Bond Transformations and Their Application to the Synthesis of Organic Functional Molecules, Synlett, 10.1055/s-0037-1610531, 2018.01, This personal account summarizes our recent progress in the development of C-H transformations. We achieved ortho -selective C-H borylations and silylations by using Lewis acid-base interaction between two substrates and we achieved meta - and ortho -selective C-H borylations by using hydrogen bonding or Lewis acid-base interaction between a hydrogen donor or Lewis acid unit of a ligand and a functional group of a substrate. Regioselective C-H trifluoromethylations and related reactions of six-membered heteroaromatic compounds were realized at their 2- and 4-positions and at their benzylic positions. In addition, we developed C-H transformations directed towards the synthesis of organic functional materials, such as highly soluble polyimides or π-conjugated molecules containing either heteroatom(s) or a Lewis acid-base interaction. 1 Introduction 2 Regioselective C-H Transformations Controlled by Noncovalent Bond Interactions 2.1 Regioselective C-H Transformations Controlled by Lewis Acid-Base Interaction between Two Substrates 2.2 Regioselective C-H Transformation Controlled by Hydrogen Bonding between Ligand and Substrate 2.3 Regioselective C-H Transformations Controlled by Lewis Acid-Base Interactions between Ligands and Substrates 3 Trifluoromethylation and Related Transformations of Six-Membered Heteroaromatic Compounds 3.1 2-Position-Selective C-H Trifluoromethylation of Six-Membered Heteroaromatic Compounds 3.2 4-Position-Selective C-H Trifluoromethylation of Six-Membered Heteroaromatic Compounds 3.3 Benzyl Position-Selective C-H Trifluoromethylation of Six-Membered Heteroaromatic Compounds 4 C-H Transformations Leading to the Synthesis of Organic Functional Materials 4.1 Heteroatom-Containing π-Conjugated Molecules 4.2 π-Conjugated Molecules Containing a Lewis Acid-Base Interaction 4.3 Soluble Polyimide Derivatives 5 Conclusions.. |
| 6. | Kuninobu, Y.; Yamamoto, M.; Nishi, M.; Yamamoto, T.; Matsuki, T.; Murai, M.; Takai, K., Rhenium-Catalyzed ortho-Alkylation of Phenols, Org. Synth., 10.15227/orgsyn.094.0280, 2017.11. |
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