| 1. |
Relationship between Circadian Phase Delay without Morning Light and Phase Advance by Bright Light Exposure the Following Morning. |
| 2. |
Yuki Motomura, Ayaka Fukuzaki, Sanami Eto, Naoki Hirabayashi, Motoharu Gondo, Satoshi Izuno, Osamu Togao, Koji Yamashita, Kazufumi Kikuchi, Nobuyuki Sudo, Kazufumi Yoshihara, Alexithymia characteristics are associated with salience network activity in healthy participants: an arterial spin labeling study., Journal of physiological anthropology, 10.1186/s40101-023-00336-1, 42, 1, 18-18, 2023.09, BACKGROUND: Alexithymia, a personality trait characterized by difficulties in identifying and expressing their emotions despite having a range of emotional experiences, can impact individuals' stress coping mechanisms. While many studies have investigated brain functions associated with specific tasks in relation to emotion processing, research focusing on resting-state brain functions has been limited. Thus, the aim of this study was to investigate the relationship between alexithymia and brain function by analyzing arterial spin labeling (ASL) data obtained during the resting state. METHODS: A brain structural and functional imaging study was conducted on 42 healthy adult men and women using ASL and the 20-item Toronto Alexithymia Scale (TAS-20) questionnaire survey. Cerebral blood flow and functional connectivity values were calculated for regions of interest in the default mode network, saliency network, and central executive network from the ASL data. Correlation analysis was performed with TAS20 scores, and partial correlation analysis was conducted to control for anxiety and depression. RESULTS: The functional connectivity analysis revealed a negative correlation between the functional connectivity of the right insular cortex and left anterior cingulate cortex and the total score of TAS, as well as difficulty identifying feelings and difficulty describing feeling subscores, indicating that the higher the scores, the weaker the functional connectivity between these regions (T = -3.830, p = 0.0013, R = -0.5180). This correlation remained significant even after controlling for anxiety and depression using partial correlation analysis. CONCLUSION: The present study revealed differences in the activity of the Saliency Network at rest as measured by ASL, which were independent of anxiety and depression, and varied depending on the severity of alexithymia. This functional change may underlie the neural basis of decreased emotional processing observed in alexithymia. These findings may contribute to the elucidation of the neural mechanisms of alexithymia, which can lead to social impairments, and suggest the usefulness of ASL measurement as a biomarker of alexithymia.. |
| 3. |
Yuri Terasawa, Kentaro Oba, Yuki Motomura, Ruri Katsunuma, Hiroki Murakami, Yoshiya Moriguchi, Paradoxical somatic information processing for interoception and anxiety in alexithymia., The European journal of neuroscience, 10.1111/ejn.15528, 54, 11, 8052-8068, 2021.12, The concept of alexithymia has garnered much attention in an attempt to understand the psychological mechanisms underlying the experience of feeling an emotion. In this study, we aimed to understand how the interoceptive processing in an emotional context relates to problems of alexithymia in recognizing self-emotions. Therefore, we prepared experimental conditions to induce emotional awareness based on interoceptive information. As such, we asked participants to be aware of interoception under an anxiety-generating situation anticipating pain, having them evaluate their subjective anxiety levels in this context. High alexithymia participants showed attenuated functional connectivity within their 'interoception network', particularly between the insula and the somatosensory areas when they focused on interoception. In contrast, they had enhanced functional connectivity between these regions when they focused on their anxiety about pain. Although access to somatic information is supposed to be more strongly activated while attending to interoception in the context of primary sensory processing, high alexithymia individuals were biased as this process was activated when they felt emotions, suggesting they recognize primitive and unprocessed bodily sensations as emotions. The paradoxical somatic information processing may reflect their brain function pathology for feeling emotions and their difficulty with context-dependent emotional control.. |
| 4. |
Taisuke Eto, Petteri Teikari, Raymond P. Najjar, Yuki Nishimura, Yuki Motomura, Manami Kuze & Shigekazu Higuchi, A Purkinje image‑based system for an assessment of the density and transmittance spectra of the human crystalline lens in vivo, Scientific Reports, 2020.09. |
| 5. |
Yoshimura, Michitaka; Kitamura, Shingo; Eto, Norihito; Hida, Akiko; Katsunuma, Ruri; Ayabe, Naoko; Motomura, Yuki; Nishiwaki, Yuji; Negishi, Kazuno; Tsubota, Kazuo; Mishima, Kazuo, Relationship between Indoor Daytime Light Exposure and Circadian Phase Response under Laboratory Free-Living Conditions, BIOLOGICAL RHYTHM RESEARCH, 10.1080/09291016.2020.1782691, 2020.06. |
| 6. |
Lee, Sang-Il; Kinoshita, Saki; Noguchi, Anna; Eto, Taisuke; Ohashi, Michihiro; Nishimura, Yuki; Maeda, Kaho; Motomura, Yuki; Awata, Yasuhiro; Higuchi, Shigekazu, Melatonin suppression during a simulated night shift in medium intensity light is increased by 10-minute breaks in dim light and decreased by 10-minute breaks in bright light, CHRONOBIOLOGY INTERNATIONAL, 10.1080/07420528.2020.1752704, 2020.04. |
| 7. |
Takashi Abe, Kazuo Mishima, Shingo Kitamura, Akiko Hida, Yuichi Inoue, Koh Mizuno, Kosuke Kaida, Kyoko Nakazaki, Yuki Motomura, Kazushi Maruo, Toshiko Ohta, Satoshi Furukawa, David F. Dinges, Katsuhiko Ogata, Tracking intermediate performance of vigilant attention using multiple eye metrics, Sleep, 10.1093/sleep/zsz219, 43, 3, 2020.03, Vigilance deficits account for a substantial number of accidents and errors. Current techniques to detect vigilance impairment measure only the most severe level evident in eyelid closure and falling asleep, which is often too late to avoid an accident or error. The present study sought to identify ocular biometrics of intermediate impairment of vigilance and develop a new technique that could detect a range of deficits in vigilant attention (VA). Sixteen healthy adults performed well-validated Psychomotor Vigilance Test (PVT) for tracking vigilance attention while undergoing simultaneous recording of eye metrics every 2 hours during 38 hours of continuous wakefulness. A novel marker was found that measured VA when the eyes were open-the prevalence of microsaccades. Notably, the prevalence of microsaccades decreased in response to sleep deprivation and time-on-task. In addition, a novel algorithm for detecting multilevel VA was developed, which estimated performance on the PVT by integrating the novel marker with other eye-related indices. The novel algorithm also tracked changes in intermediate level of VA (specific reaction times in the PVT, i.e. 300-500 ms) during prolonged time-on-task and sleep deprivation, which had not been tracked previously by conventional techniques. The implication of the findings is that this novel algorithm, named "eye-metrical estimation version of the PVT: PVT-E," can be used to reduce human-error-related accidents caused by vigilance impairment even when its level is intermediate.. |
| 8. |
Yuko Hakamata, Shotaro Komi, Eisuke Sato, Shuhei Izawa, Shinya Mizukami, Yoshiya Moriguchi, Yuki Motomura, Mie Matsui, Yoshiharu Kim, Takashi Hanakawa, Yusuke Inoue, Hirokuni Tagaya, Cortisol-related hippocampal-extrastriate functional connectivity explains the adverse effect of cortisol on visuospatial retrieval, Psychoneuroendocrinology, 10.1016/j.psyneuen.2019.04.013, 109, 2019.11, Cortisol is known to affect visuospatial memory through its major binding site in the brain, the hippocampus. The synchronization of neural activity between the hippocampus, prefrontal cortex (PFC), and visual cortex is presumed to be essential for the formation of visuospatial memory because of their visuospatial learning-dependent neuroplasticity. However, it remains unclear how hippocampal connectivity with the PFC and visual cortex is involved in the relationship between cortisol and visuospatial memory in humans. We thus investigated whether functional connectivity (FC) of the hippocampus, specifically its rostral and caudal subdivisions, mediates the relationship between visuospatial memory and endogenous cortisol. One-hundred sixty-six healthy young adults underwent standard neuropsychological tests to assess visuospatial construction (a complex figure copying test) and retrieval (the corresponding recall test) and collected their saliva at 6-time points across 2 consecutive days for measurement of daily cortisol concentrations (dCOR). Ninety of them received resting-state fMRI scans. Greater dCOR was significantly associated with better figure copying performance, but contrastingly with poorer figure recall. In proportion to dCOR, the rostral hippocampus (rHC) showed significantly increased FC with the PFC (including its dorsolateral and medial parts) and the inferior lateral occipital cortex (iLOC), while the caudal hippocampus had increased FC with the anterior middle temporal cortex. Of the cortisol-related hippocampal connectivity, the rHC-iLOC FC was specifically correlated with figure recall and showed complete mediation for the negative relationship of dCOR with figure recall. These results suggest that cortisol might have enhancing effects on visuospatial encoding as well as impairing effects on visuospatial retrieval, possibly due to its occupancy patterns of corticosteroid receptors. Cortisol's adverse effects on visuospatial retrieval might be explained through cortisol-related rostral hippocampal connectivity with the iLOC, which is a part of the extrastriate cortex implicated in visuospatial perception. Thorough dissection of hippocampal-prefrontal-extrastriate connectivity might facilitate the understanding of neural mechanisms underlying cortisol's contrasting effects on encoding (or consolidation) and retrieval of visuospatial information.. |
| 9. |
Sayuri Hayashi, Ayami Tsuru, Fumi Kishida, Yeon Kyu Kim, Shigekazu Higuchi, Yuki Motomura, ERP study on the associations of peripheral oxytocin and prolactin with inhibitory processes involving emotional distraction, Journal of physiological anthropology, 10.1186/s40101-019-0196-z, 38, 1, 2019.05, Background: Child maltreatment is a major health and social welfare problem, with serious and longstanding consequences. Impulse control ability plays an important role in reducing the risk of child maltreatment. The aim of this study was to investigate the associations of oxytocin (OXT) and prolactin (PRL) with behavior inhibition using children's facial expressions (angry or neutral) as emotional distractions. This may clarify a part of the neuroendocrinological mechanism that modulates impulse control ability in the context of child caregiving. Methods: Participants were 16 females who had never been pregnant. Following venous blood sampling for OXT and PRL levels, participants performed an emotional Go/Nogo task during their follicular and luteal phases to test inhibitory control ability. Behavioral performance and event-related potentials (ERPs) during the task were measured. Results: The results showed that there were significant fixed effects of OXT on behavioral performance, as measured by sensitivity (d-prime). This suggests that high peripheral OXT levels may be associated with better performance on the emotional Go/Nogo task, regardless of emotional distractors. PRL was associated with inhibitory processes as reflected by the Nogo-N2 and Nogo-P3. Particularly, high PRL levels were associated with the Nogo-N2 latency extension with the emotional distractors. Conclusions: Our findings suggest that OXT might be associated with improving behavioral performance regardless of emotional processes. It is suggested that processes related to PRL are related to premotor activities of behavioral inhibitions and emotions.. |
| 10. |
Hakamata, Yuko; Mizukami, Shinya; Komi, Shotaro; Sato, Eisuke; Moriguchi, Yoshiya; Motomura, Yuki; Maruo, Kazushi; Izawa, Shuhei; Kim, Yoshiharu; Hanakawa, Takashi; Inoue, Yusuke; Tagaya, Hirokuni, Attentional bias modification alters intrinsic functional network of attentional control: A randomized controlled trial, JOURNAL OF AFFECTIVE DISORDERS, 10.1016/j.jad.2018.06.018, 238, 472-481, 2018.10. |
| 11. |
Sayuri Hayashi, Hiroko Wada, Sung-Phil Kim, Yuki Motomura, Shigekazu Higuchi, Yeon-Kyu Kim, Enhanced Nogo-P3 amplitudes of mothers compared with non-mother women during an emotional Go/Nogo task: Journal of Physiological Anthropology, 2018.04. |
| 12. |
Yuki Motomura, Ruri Katsunuma, Michitaka Yoshimura, Kazuo Mishima, Two Days' Sleep Debt Causes Mood Decline During Resting State Via Diminished Amygdala-Prefrontal Connectivity, SLEEP, 10.1093/sleep/zsx133, 40, 10, 2017.10, Study objectives: Sleep debt (SD) has been suggested to evoke emotional instability by diminishing the suppression of the amygdala by the medial prefrontal cortex (MPFC). Here, we investigated how short-term SD affects resting-state functional connectivity between the amygdala and MPFC, self-reported mood, and sleep parameters.
Methods: Eighteen healthy adult men aged 29 +/- 8.24 years participated in a 2-day sleep control session (SC; time in bed [ TIB], 9 hours) and 2-day SD session (TIB, 3 hours). On day 2 of each session, resting-state functional magnetic resonance imaging was performed, followed immediately by measuring self-reported mood on the State-Trait Anxiety Inventory-State subscale (STAI-S).
Results: STAI-S score was significantly increased, and functional connectivity between the amygdala and MPFC was significantly decreased in SD compared with SC. Significant correlations were observed between reduced rapid eye movement (REM) sleep and reduced left amygdala-MPFC functional connectivity (FCL_amg-MPFC) and between reduced FCL_amg-MPFC and increased STAI-S score in SD compared with SC.
Conclusions: These findings suggest that reduced MPFC functional connectivity of amygdala activity is involved in mood deterioration under SD, and that REM sleep reduction is involved in functional changes in the corresponding brain regions. Having adequate REM sleep may be important for mental health maintenance.. |
| 13. |
Ruri Katsunuma, Kentaro Oba, Shingo Kitamura, Yuki Motomura, Yuri Terasawa, Kyoko Nakazaki, Akiko Hida, Yoshiya Moriguchi, Kazuo Mishima, Unrecognized Sleep Loss Accumulated in Daily Life Can Promote Brain Hyperreactivity to Food Cue, SLEEP, 10.1093/sleep/zsx137, 40, 10, 2017.10, Epidemiological studies have shown that sleep debt increases the risk of obesity. Experimental total sleep deprivation (TSD) has been reported to activate the reward system in response to food stimuli, but food-related responses in everyday sleep habits, which could lead to obesity, have not been addressed. Here, we report that habitual sleep time at home among volunteers without any sleep concerns was shorter than their optimal sleep time estimated by the 9-day extended sleep intervention, which indicates that participants had already been in sleep debt in their usual sleep habits. The amygdala and anterior insula, which are responsible for both affective responses and reward prediction, were found to exhibit significantly lowered activity in the optimal sleep condition. Additionally, a subsequent one-night period of TSD reactivated the right anterior insula in response to food images; however, the activity level of amygdala remained lowered. These findings indicate that (1) our brain is at risk of hyperactivation to food triggers in everyday life, which could be a risk factor for obesity and lifestyle diseases, and (2) optimal sleep appears to reduce this hypersensitivity to food stimuli.. |
| 14. |
Hakamata Y, Komi S, Moriguchi Y, Izawa S, Motomura Y, Sato E, Mizukami S, Kim Y, Hanakawa T, Inoue Y, Tagaya H, Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety.Sci Rep, 2017.08. |
| 15. |
Motomura Y, Kitamura S, Nakazaki K, Oba K, Katsunuma R, Terasawa Y, Hida A, Moriguchi Y, Mishima K., Recovery from Unrecognized Sleep Loss Accumulated in Daily Life Improved Mood Regulation via Prefrontal Suppression of Amygdala Activity.Front Neurol.8:306. 2017, 2017.07. |
| 16. |
A. Hida, Y. Ohsawa, S. Kitamura, K. Nakazaki, N. Ayabe, Y. Motomura, K. Matsui, M. Kobayashi, A. Usui, Y. Inoue, H. Kusanagi, Y. Kamei, K. Mishima, Evaluation of circadian phenotypes utilizing fibroblasts from patients with circadian rhythm sleep disorders, TRANSLATIONAL PSYCHIATRY, 10.1038/tp.2017.75, 7, 4, e1106, 2017.04, We evaluated the circadian phenotypes of patients with delayed sleep-wake phase disorder (DSWPD) and non-24-hour sleep-wake rhythm disorder (N24SWD), two different circadian rhythm sleep disorders (CRSDs) by measuring clock gene expression rhythms in fibroblast cells derived from individual patients. Bmal1-luciferase (Bmal1-luc) expression rhythms were measured in the primary fibroblast cells derived from skin biopsy samples of patients with DSWPD and N24SWD, as well as control subjects. The period length of the Bmal1-luc rhythm (in vitro period) was distributed normally and was 22.80 +/- 0.47 (mean +/- s.d.) h in control-derived fibroblasts. The in vitro periods in DSWPD-derived fibroblasts and N24SWD-derived fibroblasts were 22.67 +/- 0.67 h and 23.18 +/- 0.70 h, respectively. The N24SWD group showed a significantly longer in vitro period than did the control or DSWPD group. Furthermore, in vitro period was associated with response to chronotherapy in the N24SWD group. Longer in vitro periods were observed in the non-responders (mean +/- s.d.: 23.59 +/- 0.89 h) compared with the responders (mean +/- s.d.: 22.97 +/- 0.47 h) in the N24SWD group. Our results indicate that prolonged circadian periods contribute to the onset and poor treatment outcome of N24SWD. In vitro rhythm assays could be useful for predicting circadian phenotypes and clinical prognosis in patients with CRSDs.. |
| 17. |
Shingo Kitamura, Yasuko Katayose, Kyoko Nakazaki, Yuki Motomura, Kentaro Oba, Ruri Katsunuma, Yuri Terasawa, Minori Enomoto, Yoshiya Moriguchi, Akiko Hida, Kazuo Mishima, Estimating individual optimal sleep duration and potential sleep debt, SCIENTIFIC REPORTS, 2016.10. |
| 18. |
Hiroki Murakami, Ruri Katsunuma, Kentaro Oba, Yuri Terasawa, Yuki Motomura, Kazuo Mishima, Yoshiya Moriguchi, Neural Networks for Mindfulness and Emotion Suppression, PLOS ONE, 10.1371/journal.pone.0128005, 10, 6, 2015.06. |
| 19. |
Yuki Motomura, Akira Takeshita, Yuka Egashira, Takayuki Nishimura, Yeon-kyu Kim, Shigeki Watanuki
, Interaction between valence of empathy and familiarity: is it difficult to empathize with the positive events of a stranger?, Journal of Physiological Anthropology, 2015.03. |
| 20. |
Yuki Motomura, Akira Takeshita, Yuka Egashira, Takayuki Nishimura, Yeon-Kyu Kim, Shigeki Watanuki
, Inter-individual relationships in empathic traits and feedback-related fronto-central brain activity: an event-related potential study, JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY, 10.1186/s40101-015-0053-7, 34, 2015.03. |
| 21. |
Yuki Motomura, Shingo Kitamura, Kyoko Nakazaki, Kentaro Oba, Ruri Katsunuma, Yasuko Katayose, Akiko Hida, Yoshiya Moriguchi, Shigekazu Higuchi, Kazuo Mishima, Recovery from potential sleep debt via sleep extension may improve emotion regulation, INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 10.1016/j.ijpsycho.2014.08.892, 94, 2, 227-227, 2014.11. |
| 22. |
Kyoko Nakazaki, Shingo Kitamura, Yuki Motomura, Akiko Hida, Yuichi Kamei, Naoki Miura, Kazuo Mishima, Validity of an algorithm for determining sleep/wake states using a new actigraph, JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY, 10.1186/1880-6805-33-31, 33, 2014.10. |
| 23. |
Yuki Motomura, Shingo Kitamura, Kentaro Oba, Yuri Terasawa, Minori Enomoto, Yasuko Katayose, Akiko Hida, Yoshiya Moriguchi, Shigekazu Higuchi, Kazuo Mishima, Sleepiness induced by sleep-debt enhanced amygdala activity for subliminal signals of fear, BMC NEUROSCIENCE, 10.1186/1471-2202-15-97, 15, 2014.08. |
| 24. |
Yuki Motomura, Shingo Kitamura, Kentaro Oba, Yuri Terasawa, Minori Enomoto, Yasuko Katayose, Akiko Hida, Yoshiya Moriguchi, Shigekazu Higuchi, Kazuo Mishima, Sleep Debt Elicits Negative Emotional Reaction through Diminished Amygdala-Anterior Cingulate Functional Connectivity, PLOS ONE, 10.1371/journal.pone.0056578, 8, 2, 2013.02. |
| 25. |
Akiko Hida, Shingo Kitamura, Yosuke Ohsawa, Minori Enomoto, Yasuko Katayose, Yuki Motomura, Yoshiya Moriguchi, Kentaro Nozaki, Makiko Watanabe, Sayaka Aritake, Shigekazu Higuchi, Mie Kato, Yuichi Kamei, Shin Yamazaki, Yu-Ichi Goto, Masaaki Ikeda, Kazuo Mishima, In vitro circadian period is associated with circadian/sleep preference., Scientific reports, 2013.03. |
| 26. |
ASSOCIATION BETWEEN EMOTIONAL AWARENESS AND NEURAL CORRELATES OF INTEROCEPTION. |
| 27. |
SLEEPINESS BY SLEEP DEBT ENHANCED AMYGDALA ACTIVATION FOR SUBLIMINAL SIGNALS OF FEAR. |
| 28. |
Yuki Motomura, Shingo Kitamura, Kentaro Oba, Yuri Terasawa, Minori Enomoto, Yasuko Katayose, Akiko Hida, Yoshiya Moriguchi, Shigekazu Higuchi, Kazuo Mishima, Sleep Debt Elicits Negative Emotional Reaction through Diminished Amygdala-Anterior Cingulate Functional Connectivity, PLOS ONE, 10.1371/journal.pone.0056578, 8, 2, 2013.02, Objectives: Sleep debt reportedly increases emotional instability, such as anxiety and confusion, in addition to sleepiness and psychomotor impairment. However, the neural basis of emotional instability due to sleep debt has yet to be elucidated. This study investigated changes in emotional responses that are elicited by the simulation of short-term sleep loss and the brain regions responsible for these changes.
Subjects and Methods: Fourteen healthy adult men aged 24.1 +/- 3.3 years (range, 20-32 years) participated in a within-subject crossover study consisting of 5-day sessions of both sleep debt (4 h for time in bed) and sleep control (8 h for time in bed). On the last day of each session, participants underwent polysomnography and completed the State-Trait Anxiety Inventory and Profile of Mood States questionnaires. In addition, functional magnetic resonance imaging was conducted while performing an emotional face viewing task.
Results: Restricted sleep over the 5-day period increased the activity of the left amygdala in response to the facial expression of fear, whereas a happy facial expression did not change the activity. Restricted sleep also resulted in a significant decrease in the functional connectivity between the amygdala and the ventral anterior cingulate cortex (vACC) in proportion to the degree of sleep debt (as indicated by the percentage of slow wave sleep and delta wave power). This decrease was significantly correlated with activation of the left amygdala and deterioration of subjective mood state.
Conclusion: The results of this study suggest that continuous and accumulating sleep debt that can be experienced in everyday life can downregulate the functional suppression of the amygdala by the vACC and consequently enhance the response of the amygdala to negative emotional stimuli. Such functional alteration in emotional control may, in part, be attributed to the neural basis of emotional instability during sleep debt.. |
| 29. |
THE ASSOCIATION BETWEEN NEURAL RESPONSE AND HEART RATE VARIABILITY DURING ATTENDING TO BODILY SENSATIONS. |
| 30. |
THE NEURAL SUBSTRATES OF THE EMOTIONAL AUTOBIOGRAPHICAL MEMORY RETRIEVAL AND ITS RELATION TO ADAPTIVE COPING. |
| 31. |
WHY SLEEP DEPRIVATION RISK US OBESITY? AN FMRI STUDY. |
