Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Yuki Motomura Last modified date:2019.05.07

Assistant Professor / Physiological Anthlopology / Department of Human Science / Faculty of Design


Papers
1. Hakamata, Yuko; Mizukami, Shinya; Komi, Shotaro; Sato, Eisuke; Moriguchi, Yoshiya; Motomura, Yuki; Maruo, Kazushi; Izawa, Shuhei; Kim, Yoshiharu; Hanakawa, Takashi; Inoue, Yusuke; Tagaya, Hirokuni, Attentional bias modification alters intrinsic functional network of attentional control: A randomized controlled trial, JOURNAL OF AFFECTIVE DISORDERS, 10.1016/j.jad.2018.06.018, 238, 472-481, 2018.10.
2. Sayuri Hayashi, Hiroko Wada, Sung-Phil Kim, Yuki Motomura, Shigekazu Higuchi, Yeon-Kyu Kim, Enhanced Nogo-P3 amplitudes of mothers compared with non-mother women during an emotional Go/Nogo task: Journal of Physiological Anthropology, 2018.04.
3. Katsunuma R, Oba K, Kitamura S, Motomura Y, Terasawa Y, Nakazaki K, Hida A, Moriguchi Y, Mishima K., Unrecognized sleep loss accumulated in daily life can promote brain hyperreactivity to food cue. SLEEP, 2017.10.
4. Motomura Y, Katsunuma R, yoshimura M, Mishima K, Two Days’ Sleep Debt Causes Mood Decline During Resting State Via Diminished Amygdala-Prefrontal Connectivity, SLEEP, 2017.10, Study objectives
Sleep debt (SD) has been suggested to evoke emotional instability by diminishing the suppression of the amygdala by the medial prefrontal cortex (MPFC). Here, we investigated how short-term SD affects resting-state functional connectivity between the amygdala and MPFC, self-reported mood, and sleep parameters.

Methods
Eighteen healthy adult men aged 29 ± 8.24 years participated in a 2-day sleep control session (SC; time in bed [TIB], 9 hours) and 2-day SD session (TIB, 3 hours). On day 2 of each session, resting-state functional magnetic resonance imaging was performed, followed immediately by measuring self-reported mood on the State-Trait Anxiety Inventory-State subscale (STAI-S).

Results
STAI-S score was significantly increased, and functional connectivity between the amygdala and MPFC was significantly decreased in SD compared with SC. Significant correlations were observed between reduced rapid eye movement (REM) sleep and reduced left amygdala-MPFC functional connectivity (FCL_amg-MPFC) and between reduced FCL_amg-MPFC and increased STAI-S score in SD compared with SC.

Conclusions
These findings suggest that reduced MPFC functional connectivity of amygdala activity is involved in mood deterioration under SD, and that REM sleep reduction is involved in functional changes in the corresponding brain regions. Having adequate REM sleep may be important for mental health maintenance..
5. Hakamata Y, Komi S, Moriguchi Y, Izawa S, Motomura Y, Sato E, Mizukami S, Kim Y, Hanakawa T, Inoue Y, Tagaya H, Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety.Sci Rep, 2017.08.
6. Motomura Y, Kitamura S, Nakazaki K, Oba K, Katsunuma R, Terasawa Y, Hida A, Moriguchi Y, Mishima K., Recovery from Unrecognized Sleep Loss Accumulated in Daily Life Improved Mood Regulation via Prefrontal Suppression of Amygdala Activity.Front Neurol.8:306. 2017, 2017.07.
7. Hida A, Ohsawa Y, Kitamura S, Nakazaki K, Ayabe N, Motomura Y, Matsui K, Kobayashi M, Usui A, Inoue Y, Kusanagi H, Kamei Y, Mishima K, Evaluation of circadian phenotypes utilizing fibroblasts from patients with circadian rhythm sleep disorders. Transl Psychiatry, 7 (4): e1106, 2017., 2017.04.