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Kawakubo Masateru Last modified date:2019.10.07





E-Mail
Phone
092-642-6728
Academic Degree
Ph.D.
Field of Specialization
Medical Image Analysis
Research
Research Interests
  • Medical Image Analysis
    keyword : Medical Image, Image Analysis, Cardiac Function Analysis, Blood Flow Analysis, Magnetic Resonance Imaging
    2011.04.
Academic Activities
Reports
1. , [URL].
Papers
1. Arai H, Kawakubo M*, Abe K, Hatashima H, Sanui K, Nishimura H, and Kadokami T. *Corresponding author, Quantification of intramyocardial hemorrhage volume using magnetic resonance imaging with three-dimensional T1-weighted sequence in patients with ischemia-reperfusion injury—a semi-automated image processing technique, The International Journal of Cardiovascular Imaging, In Press, 2019.09.
2. M Kawakubo, M Nagao, U Ishizaki, Y Shina, K Inai, Y Yamasaki, M Yoneyama, S Sakai., Fractal analysis of right ventricular remodeling in adults with congenitally corrected transposition of the great arteries using cardiac magnetic resonance feature-tracking, Radiology: Cardiothoracic Imaging, In Press, 2019.08.
3. R Nakao, M Nagao, K Fukushima, A Sakai, E Watanabe, M Kawakubo, S Sakai, N Hagiwara., Prediction of Cardiac Resynchronization Therapy Response in Dilated Cardiomyopathy Using Vortex Flow Mapping on Cine Magnetic Resonance Imaging, Circulation Reports, In Press, 2019.07.
4. Kawakubo M*, Yamasaki Y, Kamitani T, Sagiyama K, Matsuura Y, Hino T, Abe K, Hosokawa K, Yabuuchi H, and Honda H. *Corresponding author, Clinical usefulness of right ventricular 3D area strain in the assessment of treatment effects of balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension: comparison with 2D feature-tracking MRI, European Radiology, https://doi.org/10.1007/s00330-019-6008-3, 29, 9, 4583-4592, 2019.09, OBJECTIVES:
To evaluate the usefulness of right ventricular (RV) area strain analysis via cardiac MRI (CMRI) as a tool for assessing the treatment effects of balloon pulmonary angioplasty (BPA) in inoperable chronic thromboembolic pulmonary hypertension (CTEPH), RV area strain was compared to two-dimensional (2D) strain with feature-tracking MRI (FTMRI) before and after BPA.
METHODS:
We retrospectively analyzed 21 CTEPH patients who underwent BPA. End-systolic global area strain (GAS), longitudinal strain (LS), circumferential strain (CS), and radial strain (RS) were measured before and after BPA. Changes in GAS and RV ejection fraction (RVEF) values after BPA were defined as ΔGAS and ΔRVEF. Receiver operating characteristic (ROC) analyses were performed to determine the optimal cutoff of the strain at after BPA for detection of improved patients with decreased mean pulmonary artery pressure (mPAP) less than 30 mmHg and increased RVEF more than 50%.
RESULTS:
ROC analysis revealed the optimal cutoffs of strains (GAS, LS, CS, and RS) for identifying improved patients with mPAP < 30 mmHg (cutoff (%) = - 41.2, - 13.8, - 16.7, and 14.4: area under the curve, 0.75, 0.56, 0.65, and 0.75) and patients with RVEF > 50% (cutoff (%) = - 37.2, - 29.5, - 2.9, and 14.4: area under the curve, 0.81, 0.60, 0.56, and 0.56).
CONCLUSIONS:
Area strain analysis via CMRI may be a more useful tool for assessing the treatment effects of BPA in patients with CTEPH than 2D strains with FTMRI..
5. Arai H, Kawakubo M, Sanui K, Nishimura H, Kadokami T., Accurate and robust systolic myocardial T1 mapping using saturation recovery with individualized delay time: Comparison with diastolic T1 mapping, Radiol Phys Technol., https://doi.org/10.1007/s12194-018-0478-x, 11, 4, 415-422, 2018.09.
6. Kawakubo M*, Arai H, Nagao M, Yamasaki Y, Sanui K, Nishimura H, Kadokami T. *Corresponding author, Global left ventricular area strain using standard two-dimensional cine MR imaging with inter-slice interpolation, Cardiovascular Imaging: Asia, https://doi.org/10.22468/cvia.2018.00108, 2, 4, 187-193, 2018.10.
7. Kojima T, Kawakubo M, Nishizaka MK, Rahmawati A, Ando S, Chishaki SA, Nakamura Y, Nagao M, Assessment by airway ellipticity on cine-MRI to differentiate severe obstructive sleep apnea., Clinical Respiratory Journal, 10.1111/crj.12598., 12, 3, 878-884, 2018.03.
8. Kawakubo M*, Akamine H, Yamasaki Y, Takemura A, Abe K, Hosokawa K, Morishita J, Nagao M. *Corresponding author, Three-dimensional phase contrast magnetic resonance imaging validated to assess pulmonary artery flow in patients with chronic thromboembolic pulmonary hypertension., Radiological Physics and Technologies, 2016.10.
9. Kawakubo M*, Nagao M, Kumazawa S, Yamasaki Y, Chishaki AS, Nakamura Y, Honda H, Morishita J. *Corresponding author, Evaluation of ventricular dysfunction using semi-automatic longitudinal strain analysis of four-chamber cine MR imaging., The International Journal of Cardiovascular Imaging., 32, 2, 283-9, 2016.02.
10. Kawakubo M*, Yamasaki Y, Sakamoto I, Yamamura K, Nagao M. *Corresponding author, Clinical Impact of Interventricular Dyssynchrony in Repaired Tetralogy of Fallot: Myocardial Strain Analysis Using Semi-automatic Tracking of Cine Magnetic Resonance Imaging., Journal of Adult Congenital Heart Disease, Vol. 4, No. 2, 69-73, 2015.12.
11. Kawakubo M*, Nagao M, Kumazawa S, Chishaki AS, Mukai Y, Nakamura Y, Honda H, Morishita J. *Corresponding author, Evaluation of cardiac dyssynchrony with longitudinal strain analysis in 4-chamber cine MR imaging., European Journal of Radiology, 82, 12, 2212-2216, 2013.12.
Presentations
1. Decelerated dark flow with steady-state free precession cine CMR imaging: Association with left ventricular myocardial strain and dyssynchrony.
2. Tsukasa Kojima, Michinobu Nagao, Takashi Shirasaka, Masateru Kawakubo, Yamato Shimomiya, Yuzo Yamasaki, Toyoyuki Kato, Shuji Sakai., Hybrid analysis of transluminal attenuation gradient and dynamic 320-detector coronary CT angiography: detection of functional coronary stenosis, European Congress of Radiology, 2019.03.
3. Arai H, Kawakubo M, Sanui K, Nishimura H, Kadokami T., How to quantify the intramyocardial hemorrhage (IMH) after reperfusion injury: comparison to various semi-automated methods, The 104th Scientific Assembly & Annual Meeting of the RSNA, 2018.11.
4. Arai H, Kawakubo M, Sanui K, Nishimura H, Kadokami T., Superiority of systolic T1 mapping with saturation recovery for errors of image registration and identification of myocardium, The 104th Scientific Assembly & Annual Meeting of the RSNA, 2018.11.
5. Kawakubo M, Fukushima K, Nakao R, Watanabe E, Shimomiya Y, Goto Y, Tadenuma H, Yoneyama M, Nagao M, Vortex flow in left ventricle interrupts efficient ejection: Demonstration by vortex flow map of cardiac cine magnetic resonance imaging, ISMRM 26th Annual Meeting & Exhibition, 2018.06.
6. Kawakubo M, Fukushima K, Nakao R, Shimomiya Y, Goto Y, Tadenuma H, Yoneyama M, Morishita J, Nagao M, Geometrical Vortex Flow in Left Ventricle Associates with Efficient Ejection: Analysis of a Novel Vortex Flow Map of 2D Cine MRI, The 45th Annual Meeting of Japanese Society of Magnetic Resonance in Medicine, 2017.09.
7. Kawakubo M, Yamasaki Y, Akamine H, Nagao M, Three-dimensional Bi-ventricular Myocardial Feature Tracking for Congenital Heart Disease Using Standard Cardiac Cine MRI with Interpolation Technique Based on Moving Gradients, ISMRM 25th Annual Meeting & Exhibition, 2017.04.
8. Kawakubo M, Yamasaki Y, Sakamoto I, Yamamura K, Nagao M, Biventricular Strain and Torsion in Adults with Corrected Transposition of the Great Arteries Analyzed by Feature Tracking Cine MRI, The 102nd Scientific Assembly & Annual Meeting of the RSNA, 2016.11.
9. Kawakubo M, Nagao M, Kumazawa S, Yonezawa M, Yamasaki Y, Honda H, Chishaki AS, Nakamura Y, Morishita J, Semi-automatic Cardiac Longitudinal Strain Analysis Using Four-chamber Cine MR Imaging: Correlation with Left Ventricular Dysfunction, The 100th Scientific Assembly & Annual Meeting of the RSNA, 2014.12.
10. Kawakubo M, Nagao M, Kumazawa S, Chishaki AS, Honda H, Morishita J, Evaluation of Cardiac Mechanical Dyssynchrony with Longitudinal Strain Analysis in 4-chamber Cine Magnetic Resonance Imaging, ISMRM 20th Annual Meeting & Exhibition, 2012.05.
11. Kawakubo M, Nagao M, Kumazawa S, Chishaki AS, Honda H, Morishita J, Evaluation of Cardiac Mechanical Dyssynchrony Using 4-chamber Cine Magnetic Resonance Imaging: Assessment of Chronic Heart Failure, European Congress of Radiology, 2012.03.
Membership in Academic Society
  • The Japanese Circulation Society (JCS)
  • Japanese Society for Magnetic Resonance in Medicine (JSMRM)
  • Japanese Society for Adult Congenital Heart Disease (JSACHD)
  • Japanese Society of Radiological Technology (JSRT)
  • The Japanese Association of Radiological Technologist (JART)
Awards
  • Vortex Flow in Left Ventricle Interrupts Efficient Ejection: Demonstration by Vortex Flow Map of Cardiac Cine Magnetic Resonance Imaging
  • Assessment of Sleep Apnea Syndrome using Airway Cine MRI
  • Evaluation of cardiac mechanical dyssynchrony with four chamber cine magnetic resonance imaging
  • Evaluation of cardiac mechanical dyssynchrony using 4-chamber cine magnetic resonance imaging: Assessment of chronic heart failure