九州大学 研究者情報
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河窪 正照(かわくぼ まさてる) データ更新日:2019.11.05



主な研究テーマ
医用画像解析
キーワード:医用画像、画像解析、心臓機能解析、血流解析、磁気共鳴画像診断
2011.04.
従事しているプロジェクト研究
診断領域線量計標準センターにおけるサーベイメータの 校正の確立(日本放射線技術学会)
2018.04~2020.03, 代表者:小山修司, 名古屋⼤学, 名古屋⼤学.
課題解決型高度医療人材養成プログラム 「実践能力強化型チーム医療加速プログラム」
2016.09~2019.03, 代表者:杜下淳次, 九州大学大学院医学研究院保健学部門.
研究業績
主要著書
1. 「ポケット英和医学用語・略語辞典」編集委員会, ポケット英和医学用語・略語辞典, 南山堂, 第13版, 2011.01.
主要原著論文
1. M Kawakubo, M Nagao, U Ishizaki, Y Shina, K Inai, Y Yamasaki, M Yoneyama, S Sakai., Feature-Tracking MRI Fractal Analysis of Right Ventricular Remodeling in Adults with Congenitally Corrected Transposition of the Great Arteries, Radiology: Cardiothoracic Imaging, 10.1148/ryct.2019190026, 1, 4, 2019.10,
Purpose
To assess a recently available technique for quantification of right ventricular (RV) trabeculae that is based on fractal analysis performed by using cardiac MRI feature tracking, in patients with congenitally corrected transposition of the great arteries (cc-TGA).
Materials and Methods
A total of 19 patients (eight men, 11 women; mean age, 35 years ± 10 [standard deviation]) with consecutive cc-TGA who underwent cardiac MRI were enrolled in the study. For analysis, patients were divided into two groups: six patients (four men, two women; mean age, 34 years ± 14) with an end-systolic RV volume index higher than 72 mL/m2 (indicative of adverse RV remodeling) and 13 patients (four men, nine women; mean age, 36 years ± 9) in whom this index was lower than or equal to 72 mL/m2 (indicative of adapted RV). The following outcomes were quantified in the midsection of the RV: fractional fractal dimension (FD) and diastolic FD, circumferential strain, and radial strain. Receiver operating characteristic (ROC) analysis was performed to determine the cutoff FD values for the detection of adverse RV remodeling. Correlations among fractional FD, diastolic FD, circumferential strain, and radial strain were calculated by using Pearson correlation coefficient (r) analysis.
Results
The following ROC values were identified for fractional and diastolic FD: cutoff, 0.09 and 1.39, respectively; area under the ROC curve, 0.95 and 0.68, respectively; sensitivity, 1.00 and 0.33, respectively; and specificity, 0.92 and 1.00, respectively. Fractional FD correlated with circumferential strain and radial strain (r = −0.70 and 0.69, respectively; P < .01), as did diastolic FD (r = 0.37 and −0.38, respectively; P < .05).
Conclusion
The fractional FD derived from cardiac MRI feature-tracking analysis correlates with adverse RV remodeling, including a changed strain pattern and trabeculae, in patients with cc-TGA..
2. Shiina Y, Taniguchi K, Nagao M, Takahashi T, Niwa K, Kawakubo M, and Inai K., The relationship between extracellular volume fraction in symptomatic adults with tetralogy of Fallot and adverse cardiac events., Journal of Cardiology, DOI: 10.1016/j.jjcc.2019.09.009., 2019.10.
3. Arai H, Kawakubo M*, Abe K, Hatashima H, Sanui K, Nishimura H, and Kadokami T. *Corresponding author, Quantification of intramyocardial hemorrhage volume using magnetic resonance imaging with three-dimensional T1-weighted sequence in patients with ischemia-reperfusion injury—a semi-automated image processing technique, The International Journal of Cardiovascular Imaging, In Press, 2019.09.
4. R Nakao, M Nagao, K Fukushima, A Sakai, E Watanabe, M Kawakubo, S Sakai, N Hagiwara., Prediction of Cardiac Resynchronization Therapy Response in Dilated Cardiomyopathy Using Vortex Flow Mapping on Cine Magnetic Resonance Imaging, Circulation Reports, In Press, 2019.07.
5. Kawakubo M*, Yamasaki Y, Kamitani T, Sagiyama K, Matsuura Y, Hino T, Abe K, Hosokawa K, Yabuuchi H, and Honda H. *Corresponding author, Clinical usefulness of right ventricular 3D area strain in the assessment of treatment effects of balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension: comparison with 2D feature-tracking MRI, European Radiology, https://doi.org/10.1007/s00330-019-6008-3, 29, 9, 4583-4592, 2019.09,
OBJECTIVES:
To evaluate the usefulness of right ventricular (RV) area strain analysis via cardiac MRI (CMRI) as a tool for assessing the treatment effects of balloon pulmonary angioplasty (BPA) in inoperable chronic thromboembolic pulmonary hypertension (CTEPH), RV area strain was compared to two-dimensional (2D) strain with feature-tracking MRI (FTMRI) before and after BPA.
METHODS:
We retrospectively analyzed 21 CTEPH patients who underwent BPA. End-systolic global area strain (GAS), longitudinal strain (LS), circumferential strain (CS), and radial strain (RS) were measured before and after BPA. Changes in GAS and RV ejection fraction (RVEF) values after BPA were defined as ΔGAS and ΔRVEF. Receiver operating characteristic (ROC) analyses were performed to determine the optimal cutoff of the strain at after BPA for detection of improved patients with decreased mean pulmonary artery pressure (mPAP) less than 30 mmHg and increased RVEF more than 50%.
RESULTS:
ROC analysis revealed the optimal cutoffs of strains (GAS, LS, CS, and RS) for identifying improved patients with mPAP < 30 mmHg (cutoff (%) = - 41.2, - 13.8, - 16.7, and 14.4: area under the curve, 0.75, 0.56, 0.65, and 0.75) and patients with RVEF > 50% (cutoff (%) = - 37.2, - 29.5, - 2.9, and 14.4: area under the curve, 0.81, 0.60, 0.56, and 0.56).
CONCLUSIONS:
Area strain analysis via CMRI may be a more useful tool for assessing the treatment effects of BPA in patients with CTEPH than 2D strains with FTMRI..
6. Arai H, Kawakubo M, Sanui K, Nishimura H, Kadokami T., Accurate and robust systolic myocardial T1 mapping using saturation recovery with individualized delay time: Comparison with diastolic T1 mapping, Radiol Phys Technol., https://doi.org/10.1007/s12194-018-0478-x, 11, 4, 415-422, 2018.09.
7. Kawakubo M*, Arai H, Nagao M, Yamasaki Y, Sanui K, Nishimura H, Kadokami T. *Corresponding author, Global left ventricular area strain using standard two-dimensional cine MR imaging with inter-slice interpolation, Cardiovascular Imaging: Asia, https://doi.org/10.22468/cvia.2018.00108, 2, 4, 187-193, 2018.10.
8. Kojima T, Kawakubo M, Nishizaka MK, Rahmawati A, Ando S, Chishaki SA, Nakamura Y, Nagao M, Assessment by airway ellipticity on cine-MRI to differentiate severe obstructive sleep apnea., Clinical Respiratory Journal, 10.1111/crj.12598., 12, 3, 878-884, 2018.03.
9. Kawakubo M*, Akamine H, Yamasaki Y, Takemura A, Abe K, Hosokawa K, Morishita J, Nagao M. *Corresponding author, Three-dimensional phase contrast magnetic resonance imaging validated to assess pulmonary artery flow in patients with chronic thromboembolic pulmonary hypertension., Radiological Physics and Technologies, 2016.10.
10. Kawakubo M*, Nagao M, Kumazawa S, Yamasaki Y, Chishaki AS, Nakamura Y, Honda H, Morishita J. *Corresponding author, Evaluation of ventricular dysfunction using semi-automatic longitudinal strain analysis of four-chamber cine MR imaging., The International Journal of Cardiovascular Imaging., 32, 2, 283-9, 2016.02.
11. Kawakubo M*, Yamasaki Y, Sakamoto I, Yamamura K, Nagao M. *Corresponding author, Clinical Impact of Interventricular Dyssynchrony in Repaired Tetralogy of Fallot: Myocardial Strain Analysis Using Semi-automatic Tracking of Cine Magnetic Resonance Imaging., Journal of Adult Congenital Heart Disease, Vol. 4, No. 2, 69-73, 2015.12.
12. Kawakubo M*, Nagao M, Kumazawa S, Chishaki AS, Mukai Y, Nakamura Y, Honda H, Morishita J. *Corresponding author, Evaluation of cardiac dyssynchrony with longitudinal strain analysis in 4-chamber cine MR imaging., European Journal of Radiology, 82, 12, 2212-2216, 2013.12.
主要総説, 論評, 解説, 書評, 報告書等
1. 長尾 充展、高橋 辰徳、椎名 由美、山崎 誘三、河窪 正照, 先天性心疾患を有する小児・成人における心臓血管核磁気共鳴のためのガイドラインとプロトコール:先天性心疾患のSCMRエキスパートコンセンサス, 2018.12.
2. 河窪 正照, 領域別最新動向:CT & MRIの技術と臨床を中心に:循環器(心臓MRIを中心に), 月刊インナービジョン2017年2月号, 2017.02.
3. 河窪 正照, MRIの最新動向, 月刊インナービジョン2017年2月号, 2017.02.
主要学会発表等
1. Kawakubo M, Nagao M, Nakao R, Watanabe E, Yoneyama M, Sakai S., SSFPシネMRIにおける減速流と左室心筋ストレインおよび左室同期障害との関連, 第47回日本磁気共鳴医学会大会, 2019.09.
2. 河窪 正照, 最新の心臓MR画像解析, 第111回 MR研究会, 2019.08.
3. 河窪 正照、長尾 充展、石崎 海子、椎名 由美、稲井 慶、山崎 誘三、米山 正巳、坂井 修二, MR画像のフラクタル解析による成人修正大血管転位における右心室リモデリングの評価 , 第89回日本心臓血管放射線研究会, 2019.07, [URL].
4. 河窪正照, 磁気共鳴画像を用いた心筋虚血再灌流傷害の非侵襲的診断法の確立, 第83回日本循環器学会学術集会, 2019.03.
5. Tsukasa Kojima, Michinobu Nagao, Takashi Shirasaka, Masateru Kawakubo, Yamato Shimomiya, Yuzo Yamasaki, Toyoyuki Kato, Shuji Sakai., Hybrid analysis of transluminal attenuation gradient and dynamic 320-detector coronary CT angiography: detection of functional coronary stenosis, European Congress of Radiology, 2019.03.
6. Arai H, Kawakubo M, Sanui K, Nishimura H, Kadokami T., How to quantify the intramyocardial hemorrhage (IMH) after reperfusion injury: comparison to various semi-automated methods, The 104th Scientific Assembly & Annual Meeting of the RSNA, 2018.11.
7. Arai H, Kawakubo M, Sanui K, Nishimura H, Kadokami T., Superiority of systolic T1 mapping with saturation recovery for errors of image registration and identification of myocardium, The 104th Scientific Assembly & Annual Meeting of the RSNA, 2018.11.
8. 河窪正照, 心臓の医用動画像を用いた視覚的かつ定量的な3次元の同期障害解析技術, 九州大学 新技術説明会, 2018.11, [URL].
9. Kawakubo M, Fukushima K, Nakao R, Watanabe E, Shimomiya Y, Goto Y, Tadenuma H, Yoneyama M, Nagao M, Vortex flow in left ventricle interrupts efficient ejection: Demonstration by vortex flow map of cardiac cine magnetic resonance imaging, ISMRM 26th Annual Meeting & Exhibition, 2018.06.
10. 河窪 正照, 福島 賢慈, 中尾 梨沙子, 下宮 大和, 後藤 康裕, 蓼沼 仁, 米山 正巳, 長尾 充展, シネMRI Vortex Flow Mapを用いた左室内渦流の幾何学的特徴と効率的駆出の関連, 第82回日本循環器学会学術集会, 2018.03.
11. Kawakubo M, Fukushima K, Nakao R, Shimomiya Y, Goto Y, Tadenuma H, Yoneyama M, Morishita J, Nagao M, Geometrical Vortex Flow in Left Ventricle Associates with Efficient Ejection: Analysis of a Novel Vortex Flow Map of 2D Cine MRI, The 45th Annual Meeting of Japanese Society of Magnetic Resonance in Medicine, 2017.09.
12. Kawakubo M, Yamasaki Y, Akamine H, Nagao M, Three-dimensional Bi-ventricular Myocardial Feature Tracking for Congenital Heart Disease Using Standard Cardiac Cine MRI with Interpolation Technique Based on Moving Gradients, ISMRM 25th Annual Meeting & Exhibition, 2017.04.
13. 河窪 正照, 山崎 誘三, 杜下 淳次, 長尾 充展, 動き勾配のパスに基づくシネ MR画像の時間的および空間的な補間による4次元の心臓MRイメージング, 第73回日本放射線技術学会総会学術大会, 2017.04.
14. Kawakubo M, Yamasaki Y, Sakamoto I, Yamamura K, Nagao M, Biventricular Strain and Torsion in Adults with Corrected Transposition of the Great Arteries Analyzed by Feature Tracking Cine MRI, The 102nd Scientific Assembly & Annual Meeting of the RSNA, 2016.11.
15. 河窪 正照, 山崎 誘三, 杜下 淳次, 長尾 充展, Feature Tracking Cine MRIによる心室の捻れ運動の評価, 第44回日本磁気共鳴医学会大会, 2016.09.
16. Kawakubo M, Nagao M, Kumazawa S, Yonezawa M, Yamasaki Y, Honda H, Chishaki AS, Nakamura Y, Morishita J, Semi-automatic Cardiac Longitudinal Strain Analysis Using Four-chamber Cine MR Imaging: Correlation with Left Ventricular Dysfunction, The 100th Scientific Assembly & Annual Meeting of the RSNA, 2014.12.
17. Kawakubo M, Nagao M, Kumazawa S, Chishaki AS, Honda H, Morishita J, Evaluation of Cardiac Mechanical Dyssynchrony with Longitudinal Strain Analysis in 4-chamber Cine Magnetic Resonance Imaging, ISMRM 20th Annual Meeting & Exhibition, 2012.05.
18. Kawakubo M, Nagao M, Kumazawa S, Chishaki AS, Honda H, Morishita J, Evaluation of Cardiac Mechanical Dyssynchrony Using 4-chamber Cine Magnetic Resonance Imaging: Assessment of Chronic Heart Failure, European Congress of Radiology, 2012.03.
特許出願・取得
特許出願件数  2件
特許登録件数  0件
学会活動
所属学会名
日本循環器学会
日本磁気共鳴医学会
日本成人先天性心疾患学会
日本放射線技術学会
公益社団法人 日本診療放射線技師会
学会大会・会議・シンポジウム等における役割
2017.01.21~2017.01.21, MR研究会, 座長(Chairmanship).
学術論文等の審査
年度 外国語雑誌査読論文数 日本語雑誌査読論文数 国際会議録査読論文数 国内会議録査読論文数 合計
2018年度      
2017年度
2016年度
2015年度
その他の研究活動
海外渡航状況, 海外での教育研究歴
Dongseo Universiy, Korea, 2019.03~2019.03.
受賞
2017年度ISMRM Travel Award, 日本磁気共鳴医学会, 2018.03.
最優秀賞, 第34回せとうち心臓CT・MR勉強会, 2016.03.
座長推薦優秀研究, 日本放射線技術学会, 2015.04.
座長推薦優秀研究, 日本放射線技術学会, 2012.04.
Cum Laude, European Society of Radiology, 2012.03.
研究資金
科学研究費補助金の採択状況(文部科学省、日本学術振興会)
2016年度~2019年度, 若手研究(B), 代表, 3次元の心臓ストレイン解析法の開発と修正大血管転位の予後予測への応用.
寄附金の受入状況
2018年度, 一般社団法人 日本循環器学会, メディカルスタッフ研究助成/磁気共鳴画像を用いた心筋虚血再灌流傷害の非侵襲的診断法の確立.
2017年度, 一般社団法人 日本磁気共鳴医学会, 2017年度ISMRM Travel Award/Vortex Flow in Left Ventricle Interrupts Efficient Ejection: Demonstration by Vortex Flow Map of Cardiac Cine Magnetic Resonance Imaging.
学内資金・基金等への採択状況
2018年度~2018年度, 数理・データサイエンスに関する教育・研究支援プログラム, 代表, Deep learningによる画像認識を応用した成人先天性心疾患の重症度自動診断システムの構築.
2018年度~2018年度, 外国語校閲経費支援, 代表, Right ventricular area strain measured with routine cine MRI after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension: Comparison with 2-dimensional feature-tracking MRI.

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