Kyushu University [Keisuke Tomohara (Assistant Professor) Faculty of Arts and Science, Division for Experimental Natural Science]

Keisuke Tomohara

Last modified date：2019.01.30

Assistant Professor / Division for Experimental Natural Science
Faculty of Arts and Science

1 Research Interests

2 Academic Activities

2.1 Papers

2.2 Reports

2.3 Presentations

E-Mail

Phone

092-802-5784

Academic Degree

Ph.D.

Field of Specialization

Medicinal chemistry

Research

Research Interests

Chemical engineering of natural product extracts
keyword : Natural product extract, Unnatural natural product
2013.04～2018.06.

Academic Activities

Reports

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1.	友原　啓介, ヨウ化アリールの連続的オルトアミノ化—イプソホウ素化反応, ファルマシア, 2015.11.
2.	Keisuke Tomohara, Another aspect in use of DMSO in medicinal chemistry, Atlas of Science, 2016.10.

Papers

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1.	Yoshikazu Horino,* Miki Suguta, Itaru Mutsuura, Keisuke Tomohara, Hitoshi Abe, Controllable Stereoselective Synthesis of (Z)- and (E)-Homoallylic Alcohols Using a Palladium-Catalyzed Three-Component Reaction, ORGANIC LETTERS, 10.1021/acs.orglett.7b02979, 19, 21, 5968-5971, 2017.11.
2.	Keisuke Tomohara,* Tomohiro Ito, Kota Furusawa, Naoto Hasegawa, Kiyushi Tsuge, Atsushi Kato, Isao Adachi, Multiple production of alpha,alpha-disubstituted amino acid derivatives through direct chemical derivatization of natural plant extracts: An apparently difficult but successful route, TETRAHEDRON LETTERS*, 10.1016/j.tetlet.2017.06.087, 58, 32, 3143-3147, 2017.08.
3.	Keisuke Tomohara,* Tomohiro Ito, Saika Onikata, Atsushi Kato, Isao Adachi, Discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under DMSO-perturbed assay conditions, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS*, 10.1016/j.bmcl.2017.01.083, 27, 7, 1620-1623, 2017.04.
4.	Keisuke Tomohara, Koji Kasamatsu, Tomoyuki Yoshimura, Takumi Furuta, Takeo Kawabata, Asymmetric Synthesis of Multisubstituted Dihydrobenzofurans by Intramolecular Conjugate Addition of Short-Lived C-O Axially Chiral Enolates, CHEMICAL & PHARMACEUTICAL BULLETIN*, 64, 7, 899-906, 2016.07.
5.	Keisuke Tomohara,* Tomohiro Ito, Saika Onikata, Kota Furusawa, Atsushi Kato, Isao Adachi, Interpreting the behavior of concentration-response curves of hyaluronidase inhibitors under DMSO-perturbed assay conditions, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS*, 10.1016/j.bmcl.2016.04.082, 26, 13, 3153-3157, 2016.07.
6.	Keisuke Tomohara,* Tomohiro Ito, Naoto Hasegawa, Atsushi Kato, Isao Adachi, Direct chemical derivatization of natural plant extract: straightforward synthesis of natural plant-like hydantoin, TETRAHEDRON LETTERS*, 10.1016/j.tetlet.2016.01.054, 57, 8, 924-927, 2016.02.

Presentations

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1.	Keisuke Tomohara, Isao Adachi, Hitoshi Kesamaru, Takeru Nose, Mechanistic Characterization of alpha-Chymotrypsin Inhibitors by DMSO-Perturbing Assay, 10th International Peptide Symposium, 2018.12.
2.	Keisuke Tomohara, DMSO-perturbing assay for identifying promiscuous enzyme inhibitors, The Third International Symposium on Toyama-Asia-Africa Pharmaceutical Network (招待講演), 2018.09.

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