Kyushu University [Keisuke Tomohara (Assistant Professor) Faculty of Arts and Science, Division for Experimental Natural Science]

Keisuke Tomohara

Last modified date：2018.09.27

Assistant Professor / Division for Experimental Natural Science
Faculty of Arts and Science

1 Research Interests

2 Academic Activities

2.1 Papers

2.2 Reports

2.3 Presentations

E-Mail

Phone

092-802-5784

Academic Degree

Ph.D.

Field of Specialization

Medicinal chemistry

Research

Research Interests

Chemical engineering of natural product extracts
keyword : Natural product extract, Unnatural natural product
2013.04～2018.06.

Academic Activities

Reports

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1.	友原　啓介, ヨウ化アリールの連続的オルトアミノ化—イプソホウ素化反応, ファルマシア, 2015.11.
2.	Keisuke Tomohara, Another aspect in use of DMSO in medicinal chemistry, Atlas of Science, 2016.10.

Papers

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1.	Yoshikazu Horino, Miki Suguta, Itaru Mutsuura, Keisuke Tomohara, Hitoshi Abe, Controllable Stereoselective Synthesis of (Z)- and (E)-Homoallylic Alcohols Using a Palladium-Catalyzed Three-Component Reaction, ORGANIC LETTERS, 10.1021/acs.orglett.7b02979, 19, 21, 5968-5971, 2017.11.
2.	Keisuke Tomohara, Tomohiro Ito, Kota Furusawa, Naoto Hasegawa, Kiyushi Tsuge, Atsushi Kato, Isao Adachi, Multiple production of alpha,alpha-disubstituted amino acid derivatives through direct chemical derivatization of natural plant extracts: An apparently difficult but successful route, TETRAHEDRON LETTERS, 10.1016/j.tetlet.2017.06.087, 58, 32, 3143-3147, 2017.08, 混合物からなる薬用植物抽出エキスそのものを用いたBucherer-Bergs反応により、四置換不斉炭素を有する複数の新規アミノ酸誘導体を一挙に合成することができた。.
3.	Keisuke Tomohara, Tomohiro Ito, Saika Onikata, Atsushi Kato, Isao Adachi, Discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under DMSO-perturbed assay conditions, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 10.1016/j.bmcl.2017.01.083, 27, 7, 1620-1623, 2017.04.
4.	Keisuke Tomohara, Koji Kasamatsu, Tomoyuki Yoshimura, Takumi Furuta, Takeo Kawabata, Asymmetric Synthesis of Multisubstituted Dihydrobenzofurans by Intramolecular Conjugate Addition of Short-Lived C-O Axially Chiral Enolates, CHEMICAL & PHARMACEUTICAL BULLETIN, 64, 7, 899-906, 2016.07.
5.	Keisuke Tomohara, Tomohiro Ito, Saika Onikata, Kota Furusawa, Atsushi Kato, Isao Adachi, Interpreting the behavior of concentration-response curves of hyaluronidase inhibitors under DMSO-perturbed assay conditions, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 10.1016/j.bmcl.2016.04.082, 26, 13, 3153-3157, 2016.07, ヒアルロニダーゼ阻害剤の酵素活性部位特異性を評価するための新たな評価方法を開発した。すなわち、DMSO摂動条件下のin vitro評価系において、ヒアルロニダーゼ阻害剤のDMSO濃度依存的な阻害活性の低下により、活性部位非特異的な阻害様式を見極めることができた。.
6.	Keisuke Tomohara, Tomohiro Ito, Naoto Hasegawa, Atsushi Kato, Isao Adachi, Direct chemical derivatization of natural plant extract: straightforward synthesis of natural plant-like hydantoin, TETRAHEDRON LETTERS, 10.1016/j.tetlet.2016.01.054, 57, 8, 924-927, 2016.02.

Presentations

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1.	Keisuke Tomohara, DMSO-perturbing assay for identifying promiscuous enzyme inhibitors, The Third International Symposium on Toyama-Asia-Africa Pharmaceutical Network, Invited, 2018.09.

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