Kyushu University Academic Staff Educational and Research Activities Database
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Keisuke Tomohara Last modified date:2019.06.13





E-Mail
Phone
092-802-5784
Academic Degree
Ph.D. (Kyoto University)
Field of Specialization
Medicinal chemistry
ORCID(Open Researcher and Contributor ID)
0000-0003-2305-5963
Research
Research Interests
  • Mechanistic characterization of enzyme inhibitors by solvent-perturbation assay
    keyword : Perturbation
    2013.04.
  • Chemical engineering of natural product extracts
    keyword : Natural product extract, Unnatural natural product
    2013.04.
Academic Activities
Reports
1. 友原 啓介, ヨウ化アリールの連続的オルトアミノ化—イプソホウ素化反応, ファルマシア, 2015.11.
2. Keisuke Tomohara, Another aspect in use of DMSO in medicinal chemistry, Atlas of Science, 2016.10.
Papers
1. Keisuke Tomohara,* Isao Adachi, Yoshikazu Horino, Hitoshi Kesamaru, Hitoshi Abe, Keitaro Suyama, Takeru Nose*, DMSO-Perturbing Assay for Identifying Promiscuous Enzyme Inhibitors., ACS Medicinal Chemistry Letters, 10.1021/acsmedchemlett.9b00093, Just Accepted Manuscript, 2019.05.
2. Yoshikazu Horino,* Miki Suguta, Itaru Mutsuura, Keisuke Tomohara, Hitoshi Abe, Controllable Stereoselective Synthesis of (Z)- and (E)-Homoallylic Alcohols Using a Palladium-Catalyzed Three-Component Reaction, ORGANIC LETTERS, 10.1021/acs.orglett.7b02979, 19, 21, 5968-5971, 2017.11.
3. Keisuke Tomohara,* Tomohiro Ito, Kota Furusawa, Naoto Hasegawa, Kiyushi Tsuge, Atsushi Kato, Isao Adachi*, Multiple production of alpha,alpha-disubstituted amino acid derivatives through direct chemical derivatization of natural plant extracts: An apparently difficult but successful route, TETRAHEDRON LETTERS, 10.1016/j.tetlet.2017.06.087, 58, 32, 3143-3147, 2017.08.
4. Keisuke Tomohara,* Tomohiro Ito, Saika Onikata, Atsushi Kato, Isao Adachi*, Discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under DMSO-perturbed assay conditions, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 10.1016/j.bmcl.2017.01.083, 27, 7, 1620-1623, 2017.04.
Presentations
1. Keisuke Tomohara, Isao Adachi, Hitoshi Kesamaru, Takeru Nose, Mechanistic Characterization of alpha-Chymotrypsin Inhibitors by DMSO-Perturbing Assay, 10th International Peptide Symposium, 2018.12.
2. Keisuke Tomohara, DMSO-perturbing assay for identifying promiscuous enzyme inhibitors, The Third International Symposium on Toyama-Asia-Africa Pharmaceutical Network (招待講演), 2018.09, Abstract: Nonspecific binding inhibitors of alpha-chymotrypsin, beta-lactamase, and hyaluronidase could be identified by the DMSO-perturbation assay..