Kyushu University [Keisuke Tomohara (Assistant Professor) Faculty of Arts and Science, Division for Experimental Natural Science]

Keisuke Tomohara

Last modified date：2019.11.11

Assistant Professor / Division for Experimental Natural Science
Faculty of Arts and Science

2 Academic Activities

E-Mail

Phone

092-802-5784

Academic Degree

Ph.D. (Kyoto University)

Field of Specialization

Medicinal chemistry

ORCID(Open Researcher and Contributor ID)

0000-0003-2305-5963

Research

Research Interests

Mechanistic characterization of enzyme inhibitors by solvent-perturbation assay
keyword : Perturbation
2013.04.
Chemical engineering of natural product extracts
keyword : Natural product extract, Unnatural natural product
2013.04.

Academic Activities

Reports

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1.	友原　啓介, ヨウ化アリールの連続的オルトアミノ化—イプソホウ素化反応, ファルマシア, 2015.11.
2.	Keisuke Tomohara, Another aspect in use of DMSO in medicinal chemistry, Atlas of Science, 2016.10.

Papers

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1.	Keisuke Tomohara, Naoto Hasegawa, Isao Adachi, Yoshikazu Horino, Takeru Nose., Early identification of promiscuous attributes of aldose reductase inhibitors using a DMSO-perturbation assay., Bioorg. Med. Chem. Lett., In press, 2019.11.
2.	Keisuke Tomohara, Isao Adachi, Yoshikazu Horino, Hitoshi Kesamaru, Hitoshi Abe, Keitaro Suyama, Takeru Nose., DMSO-Perturbing Assay for Identifying Promiscuous Enzyme Inhibitors., ACS Med. Chem. Lett., 10.1021/acsmedchemlett.9b00093, 10, 923-928, 2019.05.
3.	Yoshikazu Horino, Miki Suguta, Itaru Mutsuura, Keisuke Tomohara, Hitoshi Abe., Controllable Stereoselective Synthesis of (Z)- and (E)-Homoallylic Alcohols Using a Palladium-Catalyzed Three-Component Reaction, Org. Lett.*, 10.1021/acs.orglett.7b02979, 19, 21, 5968-5971, 2017.11.
4.	Keisuke Tomohara, Tomohiro Ito, Kota Furusawa, Naoto Hasegawa, Kiyushi Tsuge, Atsushi Kato, Isao Adachi., Multiple production of alpha,alpha-disubstituted amino acid derivatives through direct chemical derivatization of natural plant extracts: An apparently difficult but successful route, Tetrahedron Lett., 10.1016/j.tetlet.2017.06.087, 58, 32, 3143-3147, 2017.08.
5.	Keisuke Tomohara, Tomohiro Ito, Saika Onikata, Atsushi Kato, Isao Adachi., Discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under DMSO-perturbed assay conditions, Bioorg. Med. Chem. Lett., 10.1016/j.bmcl.2017.01.083, 27, 7, 1620-1623, 2017.04.

Presentations

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1.	Keisuke Tomohara, Isao Adachi, Hitoshi Kesamaru, Takeru Nose, Mechanistic Characterization of alpha-Chymotrypsin Inhibitors by DMSO-Perturbing Assay, 10th International Peptide Symposium, 2018.12.
2.	Keisuke Tomohara, DMSO-perturbing assay for identifying promiscuous enzyme inhibitors, The Third International Symposium on Toyama-Asia-Africa Pharmaceutical Network (招待講演), 2018.09, Abstract: Nonspecific binding inhibitors of alpha-chymotrypsin, beta-lactamase, and hyaluronidase could be identified by the DMSO-perturbation assay..

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