Kyushu University Academic Staff Educational and Research Activities Database
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Keisuke Tomohara Last modified date:2019.01.30

Academic Degree
Field of Specialization
Medicinal chemistry
Research Interests
  • Chemical engineering of natural product extracts
    keyword : Natural product extract, Unnatural natural product
Academic Activities
1. 友原 啓介, ヨウ化アリールの連続的オルトアミノ化—イプソホウ素化反応, ファルマシア, 2015.11.
2. Keisuke Tomohara, Another aspect in use of DMSO in medicinal chemistry, Atlas of Science, 2016.10.
1. Yoshikazu Horino,* Miki Suguta, Itaru Mutsuura, Keisuke Tomohara, Hitoshi Abe, Controllable Stereoselective Synthesis of (Z)- and (E)-Homoallylic Alcohols Using a Palladium-Catalyzed Three-Component Reaction, ORGANIC LETTERS, 10.1021/acs.orglett.7b02979, 19, 21, 5968-5971, 2017.11.
2. Keisuke Tomohara,* Tomohiro Ito, Kota Furusawa, Naoto Hasegawa, Kiyushi Tsuge, Atsushi Kato, Isao Adachi*, Multiple production of alpha,alpha-disubstituted amino acid derivatives through direct chemical derivatization of natural plant extracts: An apparently difficult but successful route, TETRAHEDRON LETTERS, 10.1016/j.tetlet.2017.06.087, 58, 32, 3143-3147, 2017.08.
3. Keisuke Tomohara,* Tomohiro Ito, Saika Onikata, Atsushi Kato, Isao Adachi*, Discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under DMSO-perturbed assay conditions, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 10.1016/j.bmcl.2017.01.083, 27, 7, 1620-1623, 2017.04.
4. Keisuke Tomohara, Koji Kasamatsu, Tomoyuki Yoshimura, Takumi Furuta, Takeo Kawabata*, Asymmetric Synthesis of Multisubstituted Dihydrobenzofurans by Intramolecular Conjugate Addition of Short-Lived C-O Axially Chiral Enolates, CHEMICAL & PHARMACEUTICAL BULLETIN, 64, 7, 899-906, 2016.07.
5. Keisuke Tomohara,* Tomohiro Ito, Saika Onikata, Kota Furusawa, Atsushi Kato, Isao Adachi*, Interpreting the behavior of concentration-response curves of hyaluronidase inhibitors under DMSO-perturbed assay conditions, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 10.1016/j.bmcl.2016.04.082, 26, 13, 3153-3157, 2016.07.
6. Keisuke Tomohara,* Tomohiro Ito, Naoto Hasegawa, Atsushi Kato, Isao Adachi*, Direct chemical derivatization of natural plant extract: straightforward synthesis of natural plant-like hydantoin, TETRAHEDRON LETTERS, 10.1016/j.tetlet.2016.01.054, 57, 8, 924-927, 2016.02.
1. Keisuke Tomohara, Isao Adachi, Hitoshi Kesamaru, Takeru Nose, Mechanistic Characterization of alpha-Chymotrypsin Inhibitors by DMSO-Perturbing Assay, 10th International Peptide Symposium, 2018.12.
2. Keisuke Tomohara, DMSO-perturbing assay for identifying promiscuous enzyme inhibitors, The Third International Symposium on Toyama-Asia-Africa Pharmaceutical Network (招待講演), 2018.09.