| 1. |
Mitsuru Watanabe, NfL and other candidate biomarkers in MS & NMOSD, PACTRIMS 2023, 2023.11, Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system. In clinical practice, disease activity is mainly assessed by clinical evaluation and neuroimaging. However, more sensitive biomarkers reflecting disease activity are needed to improve the prognosis. The levels of neurofilament light chain (NfL), one of three types of neuronal intermediate filament, elevate upon neuroaxonal damage not only in cerebrospinal fluid but also in blood. In MS, many studies showed that blood NfL can be a good biomarker representing disease activity, treatment response and prognosis. Therefore, blood NfL is expected to be used in daily clinical practice in the future to monitor disease activity and predict prognosis in each individual. Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune astrocytopathy mediated by anti-aquaporin 4 antibody that typically presents with severe and recurrent attacks in the optic nerve and spinal cord. Glial fibrillary acidic protein (GFAP), an intermediate filament of astrocytes, in blood is reported to be associated with disease activity and disability in NMOSD. This lecture provides updates on biofluid biomarkers including NfL and GFAP in MS and NMOSD and discuss whether they can be applied to clinical practice.. |
| 2. |
Mitsuru Watanabe, Katsuhisa Masaki, Eizo Tanaka, Takuya Matsushita, Noriko Isobe, Efficacy of Eculizumab in Acute Phase of Neuromyelitis Optica Spectrum Disorder: A Case Series Study, PACTRIMS 2023, 2023.11. |
| 3. |
Mitsuru Watanabe, Katsuhisa Masaki, Eizo Tanaka, Takuya Matsushita, Noriko Isobe, Case series of eculizumab treatment on NMOSD attacks, MS Milan2023, 2023.10. |
| 4. |
渡邉充, 磯部紀子, 新野正明, 中島一郎, 松下拓也, 酒井康成, 中原仁, 河内泉, 越智博文, 中辻裕司, 中村好一, 中村幸志, 坂田清美, 松井真, 桑原聡, 吉良潤一, 第5回全国調査からみる多発性硬化症の二次性進行型に移行するリスク因子の検討, 第34回日本神経免疫学会学術集会, 2022.10. |
| 5. |
渡邉充, 磯部紀子, 新野正明, 中島一郎, 松下拓也, 酒井康成, 中原仁, 河内泉, 越智博文, 中辻 裕司, 中村好一, 中村幸志, 坂田清美, 松井真, 桑原聡, 吉良潤一, 第5回全国調査からみた多発性硬化症の重症度に寄与する因子の検討., 第33回日本神経免疫学会学術集会, 2021.10. |
| 6. |
Mitsuru Watanabe, Noriko Isobe, Takuya Matsushita, Aleksandra Maceski, Yuri Nakamura, Katsuhisa Masaki, Jun-ichi Kira*, David Leppert*, Jens Kuhle*
*These authors contributed equally to the manuscript.
, Serum glial fibrillary acidic protein, but not S100B or neurofilament light chain predicts future relapses in neuromyelitis optica spectrum disorders, MSVirtual 2020 (8th Joint ACTRIMS-ECTRIMS Meeting), 2020.09. |
| 7. |
渡邉充, 中村優理, 磯部紀子, 田中正美、松下拓也, 河野祐治, 迫田礼子, 林史恵, 吉良潤一, 日本人多発性硬化症における疾患修飾薬関連進行性多巣性白質脳症リスクにHLAアリル多型が関与する, 第31回日本神経免疫学会学術集会, 2019.09. |
| 8. |
Mitsuru Watanabe, Yuri Nakamura, Noriko Isobe, Masami Tanaka, Ayako Sakoda, Fumie Hayashi, Takuya Matsushita, Jun-ichi Kira, Effect of HLA class II alleles on JCV infection in Japanese patients with multiple sclerosis, ECTRIMS 2019, 2019.09. |
| 9. |
Mitsuru Watanabe, Yuri Nakamura, Zuzanna Michalak, Fumie Hayashi, Christian Barro, David Leppert, Noriko Isobe, Takuya Matsushita, Ryo Yamasaki, Jens Kuhle, Jun-ichi Kira, Serum GFAP and neurofilament light as biomarkers of disease activity and disability in NMOSD and MS, 第60回日本神経学会学術大会, 2019.05. |
| 10. |
渡邉充, 中村優理, 磯部紀子, 松下拓也, 迫田礼子, 林史恵, 吉良潤一, 日本人多発性硬化症における疾患修飾薬関連進行性多巣性白質脳症のリスクにHLAクラスIIアリルが関与する, 第116回日本内科学会総会・講演会, 2019.04. |
| 11. |
Mitsuru Watanabe, Yuri Nakamura, Zuzanna Michalak, Fumie Hayashi, Christian Barro, Noriko Isobe, Takuya Matsushita, Ryo Yamasaki, Jens Kuhle, Jun-ichi Kira
, Serum GFAP and NfL as potential biomarkers for disease activity and disability progression in NMOSD and MS
, 第5回MSサマーカレッジ, 2018.08. |
| 12. |
渡邉 充、中村 優理、Zuzanna Michalak、林 史恵、Christian Barro、磯部 紀子、松下 拓也、山﨑 亮、Jens Kuhle、吉良 潤一, 血清GFAPとニューロフィラメント軽鎖は視神経脊髄炎関連疾患や多発性硬化症の障害度や再発率と相関する
, 第30回日本神経免疫学会学術集会, 2018.09. |
| 13. |
Mitsuru Watanabe, Yuri Nakamura, Zuzanna Michalak, Fumie Hayashi, Christian Barro, Noriko Isobe, Takuya Matsushita, Ryo Yamasaki, Jens Kuhle, Jun-ichi Kira, Serum glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) in neuromyelitis optica spectrum disorders, ECTRIMS 2018, 2018.10. |
| 14. |
渡邉 充, 中村 優理, 磯部 紀子, 松下 拓也, 迫田 礼子, 林 史恵, 吉良 潤一
, 日本人多発性硬化症ではHLA-DRB1*15:01が JCV感染リスクを下げDR4がリスクを上げる, 第23回神経感染症学会総会・学術大会, 2018.10. |
| 15. |
Mitsuru Watanabe, Yuri Nakamura, Zuzanna Michalak, Fumie Hayashi, Christian Barro, Noriko Isobe, Takuya Matsushita, Ryo Yamasaki, Jens Kuhle, Jun-ichi Kira
, Serum glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) as potential biomarkers for disease activity and disability in neuromyelitis optica spectrum disorders and multiple sclerosis
, 11th PACTRIMS Congress, 2018.11. |
| 16. |
渡邉 充、白石 渉、山﨑 亮、磯部 紀子、吉良 潤一, Facial onset sensory and motor neuronopathy症候群は早期からoral phase dysphagiaを呈する, 第36回日本神経治療学会学術集会, 2018.11. |
