九州大学-研究者情報 [熊丸浩仁 (講師) 九州大学病院別府病院整形外科]

熊丸浩仁（くままるひろみ）

データ更新日：2024.04.21

講師　／　九州大学病院別府病院整形外科

1 主な研究テーマ

2 研究業績

2.1 原著論文

2.2 学会発表等

2.3 その他の優れた研究業績

3 受賞

4 研究資金

4.1 日本学術振興会への採択...

主な研究テーマ

脊髄損傷に対する神経幹細胞移植療法
キーワード：脊髄損傷　神経幹細胞　再生医療　皮質脊髄路　多能性幹細胞　
2009.04.

研究業績

主要原著論文

全てを見る→

1.	1. Sinopoulou E, Rosenzweig ES, Conner JM, Gibbs D, Weinholtz CA, Weber JL, Brock JH, Nout-Lomas YS, Ovruchesky E, Takashima Y, Biane JS, Kumamaru H, Havton LA, Beattie MS, Bresnahan JC, Tuszynski MH, Rhesus macaque versus rat divergence in the corticospinal projectome, Neuron, 2022.09.
2.	Hiromi Kumamaru, Ken Kadoya, Andrew F. Adler, Yoshio Takashima, Lori Graham, Giovanni Coppola, Mark H. Tuszynski, Generation and post-injury integration of human spinal cord neural stem cells, Nature Methods, 10.1038/s41592-018-0074-3, 15, 9, 723-731, 2018.09, [URL], Spinal cord neural stem cells (NSCs) have great potential to reconstitute damaged spinal neural circuitry, but they have yet to be generated in vitro. We now report the derivation of spinal cord NSCs from human pluripotent stem cells (hPSCs). Our observations show that these spinal cord NSCs differentiate into a diverse population of spinal cord neurons occupying multiple positions along the dorso-ventral axis, and can be maintained for prolonged time periods. Grafts into injured spinal cords were rich with excitatory neurons, extended large numbers of axons over long distances, innervated their target structures, and enabled robust corticospinal regeneration. The grafts synaptically integrated into multiple host intraspinal and supraspinal systems, including the corticospinal projection, and improved functional outcomes after injury. hPSC-derived spinal cord NSCs could enable a broad range of biomedical applications for in vitro disease modeling and constitute an improved clinically translatable cell source for ‘replacement’ strategies in several spinal cord disorders..
3.	Hiromi Kumamaru, Paul Lu, Ephron S. Rosenzweig, Ken Kadoya, Mark H. Tuszynski, Regenerating Corticospinal Axons Innervate Phenotypically Appropriate Neurons within Neural Stem Cell Grafts, Cell Reports, 10.1016/j.celrep.2019.01.099, 26, 9, 2329-2339.e4, 2019.02, [URL], Neural progenitor cell grafts form new relays across sites of spinal cord injury (SCI). Using a panel of neuronal markers, we demonstrate that spinal neural progenitor grafts to sites of rodent SCI adopt diverse spinal motor and sensory interneuronal fates, representing most neuronal subtypes of the intact spinal cord, and spontaneously segregate into domains of distinct cell clusters. Host corticospinal motor axons regenerating into neural progenitor grafts innervate appropriate pre-motor interneurons, based on trans-synaptic tracing with herpes simplex virus. A human spinal neural progenitor cell graft to a non-human primate also received topographically appropriate corticospinal axon regeneration. Thus, grafted spinal neural progenitor cells give rise to a variety of neuronal progeny that are typical of the normal spinal cord; remarkably, regenerating injured adult corticospinal motor axons spontaneously locate appropriate motor domains in the heterogeneous, developing graft environment, without a need for additional exogenous guidance. Kumamaru et al. demonstrate that spinal cord neural progenitor cell grafts spontaneously segregate into motor and sensory domains when implanted into sites of spinal cord injury in rats and primates. Host corticospinal axons regenerating into grafts preferentially regenerate and synapse onto motor interneuron-rich domains, avoiding inappropriate sensory domains..

主要学会発表等

全てを見る→

その他の優れた研究業績

2016.03, Spinal cord injury research on the translational Spectrum (SCIRTS)　Postdoctoral fellowship, Craig H. Neilsen foundation.

受賞

第35回　日本整形外科学会基礎学術集会　最優秀ポスター賞, 日本整形外科学会, 2020.10.

令和１年度日本整形外科学会　奨励賞, 日本整形外科学会, 2020.05.

研究奨励賞 (骨々賞), 九州大学　整形外科, 2012.12.

奨励賞 (大正富山Award), 日本脊椎脊髄病学会, 2014.04.

研究資金

日本学術振興会への採択状況(科学研究費補助金以外)

2015年度～2016年度, 海外特別研究員, IPS細胞を用いた脊髄損傷の治療に関する基礎研究.

九大関連コンテンツ

pure2017年10月2日から、「九州大学研究者情報」を補完するデータベースとして、Elsevier社の「Pure」による研究業績の公開を開始しました。

QIR　九州大学学術情報リポジトリシステム情報科学研究院

九州大学病院


	※ 研究者情報全体を検索する場合は右端の「すべて」を選択して下さい。