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Michinari Hieda Last modified date：2023.07.05

Assistant Professor / Department of Basic Medicine
Faculty of Medical Sciences


Administration Post
Other


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Homepage
https://kyushu-u.pure.elsevier.com/en/persons/michinari-hieda
　Reseacher Profiling Tool　Kyushu University Pure
https://www.1nai.med.kyushu-u.ac.jp/
Home Page .
Phone
092-642-6117
Fax
092-642-5247
Academic Degree
PhD, MS
Country of degree conferring institution (Overseas)
No
Field of Specialization
Cardiology
ORCID(Open Researcher and Contributor ID)
0000-0003-3434-6184
Total Priod of education and research career in the foreign country
04years00months
Research
Research Interests
  • Cardiac function, Cardiac energetics, Pressure-Volume loop、advanced heart failure, left ventricular assist device
    keyword : Cardiac function, Cardiac energetics, Pressure-Volume loop、advanced heart failure, left ventricular assist device
    2020.04～2031.04.
Academic Activities
Books
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1. Hieda M, Esposito G, Bossone, Cardiovascular Emergencies, Part II, An Issue of Heart Failure Clinics (Volume 16-3), Elsevier, 2020.06.
2. Hieda M, Esposito G, Bossone, Cardiovascular Emergencies, Part I, An Issue of Heart Failure Clinics, E-Book (The Clinics: Internal Medicine), Elsevier, 2020.04.
Reports
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Papers
 Show All Papers >>
1. Hieda M, Levine BD, Response by Hieda and Levine to Letter Regarding Article, "One-Year Committed Exercise Training Reverses Abnormal Left Ventricular Myocardial Stiffness in Patients With Stage B Heart Failure With Preserved Ejection Fraction"., Circulation, 10.1161/CIRCULATIONAHA.122.058733, 145, 9, e644, 2022.03.
2. Hieda M, Sarma S, Hearon CM Jr, MacNamara JP, Dias KA, Samels M, Palmer D, Livingston S, Morris M, Levine BD. , One-Year Committed Exercise Training Reverses Abnormal Left Ventricular Myocardial Stiffness in Patients With Stage B Heart Failure With Preserved Ejection Fraction, Circulation, 10.1161/CIRCULATIONAHA.121.054117, 144, 12, 934-946, 2021.09.
3. Tran T, Muralidhar A, Hunter K, Buchanan C, Coe G, Hieda M, Tompkins C, Zipse M, Spotts MJ, Laing SG, Fosmark K, Hoffman J, Ambardekar AV, Wolfel EE, Lawley J, Levine B, Kohrt WM, Pal J, Cornwell WK 3rd., Right ventricular function and cardiopulmonary performance among patients with heart failure supported by durable mechanical circulatory support devices., J Heart Lung Transplant, 10.1016/j.healun.2020.11.009, 40, 2, 128-137, 2021.02, BACKGROUND
Patients with continuous-flow left ventricular assist devices (CF-LVADs) experience limitations in functional capacity and frequently, right ventricular (RV) dysfunction. We sought to characterize RV function in the context of global cardiopulmonary performance during exercise in this population.

METHODS
A total of 26 patients with CF-LVAD (aged 58 ± 11 years, 23 males) completed a hemodynamic assessment with either conductance catheters (Group 1, n = 13) inserted into the right ventricle to generate RV pressure‒volume loops or traditional Swan‒Ganz catheters (Group 2, n = 13) during invasive cardiopulmonary exercise testing. Hemodynamics were collected at rest, 2 sub-maximal levels of exercise, and peak effort. Breath-by-breath gas exchange parameters were collected by indirect calorimetry. Group 1 participants also completed an invasive ramp test during supine rest to determine the impact of varying levels of CF-LVAD support on RV function.

RESULTS
In Group 1, pump speed modulations minimally influenced RV function. During upright exercise, there were modest increases in RV contractility during sub-maximal exercise, but there were no appreciable increases at peak effort. Ventricular‒arterial coupling was preserved throughout the exercise. In Group 2, there were large increases in pulmonary arterial, left-sided filling, and right-sided filling pressures during sub-maximal and peak exercises. Among all participants, the cardiac output‒oxygen uptake relationship was preserved at 5.8:1. Ventilatory efficiency was severely abnormal at 42.3 ± 11.6.

CONCLUSIONS
Patients with CF-LVAD suffer from limited RV contractile reserve; marked elevations in pulmonary, left-sided filling, and right-sided filling pressures during exercise; and severe ventilatory inefficiency. These findings explain mechanisms for persistent reductions in functional capacity in this patient population..
4. Hieda M, Esposito G, Bossone E, Novel Clinical and Pathophysiologic Concepts in Cardiovascular Emergencies., Heart Fail Clin., 10.1016/j.hfc.2020.04.001, 16, 3, XI-XII, 2020.07.
5. Hieda M, Noninvasive Positive Pressure Ventilation for Acute Decompensated Heart Failure., Heart Fail Clin., 10.1016/j.hfc.2020.02.005, 16, 3, 271-282, 2020.07.
6. Hieda M, Goto Y, Cardiac Mechanoenergetics in Patients with Acute Myocardial Infarction: From Pressure-Volume Loop Diagram Related to Cardiac Oxygen Consumption., Heart Fail Clin., 10.1016/j.hfc.2020.02.002, 16, 3, 255-269, 2020.07.
7. Hieda M, Esposito G, Bossone E, The Latest Clinical Understandings and Theory of the Cardiovascular Systems for Cardiovascular Emergencies and Their Management., Heart Fail Clin, 10.1016/j.hfc.2020.01.001, 16, 2, Ⅸ-Ⅹ, 2020.04.
8. Hieda M, Satyam S, Hearon Jr. C, Dias K, Martinez J, Samels M, Everding B, Palmer D, Livingston S, Morris M, Howden E, Levine BD, Increased Myocardial Stiffness in Patients With High-Risk Left Ventricular Hypertrophy: The Hallmark of Stage-B Heart Failure With Preserved Ejection., Circulation, 10.1161/CIRCULATIONAHA.119.040332, 141, 2, 115-123, 2019.12.
9. Hieda M, Yoo JK, Badrov BM, Parker SR, Anderson HE, Wiblin LJ, Kawalsky J, North SC, Suris A, and Fu Q, Reduced Left Ventricular Diastolic Function in Women with Post-Traumatic Stress Disorder., American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 10.1152/ajpregu.00002.2019, 317, 1, 108-112, 2019.07.
10. Hieda M, Howden E, Sarma S, Cornwell W, Lawley J, Tarumi T, Palmer D, Samels M, Everding B, Livingston S, Fu Q, Zhang R, and Levine BD, The Impact of 2-Years of High Intensity Exercise Training on a Model of Integrated Cardiovascular Regulation., Journal of Physiology, 10.1113/JP276676, 597, 2, 419-429, 2019.01, KEY POINTS: Heart rate variability, a common and easily measured index of cardiovascular dynamics, is the output variable of complicated cardiovascular and respiratory control systems. Both neural and non-neural control mechanisms may contribute to changes in heart rate variability. We previously developed an innovative method using transfer function analysis to assess the effect of prolonged exercise training on integrated cardiovascular regulation. In the present study, we modified and applied this to investigate the effect of 2 years of high-intensity training on circulatory components to tease out the primary effects of training. Our method incorporated the dynamic Starling mechanism, dynamic arterial elastance and arterial-cardiac baroreflex function. The dynamic Starling mechanism gain and arterial-cardiac baroreflex gain were significantly increased in the exercise group. These parameters remained unchanged in the controls. Conversely, neither group experienced a change in dynamic arterial elastance. The integrated cardiovascular regulation gain in the exercise group was 1.34-fold larger than that in the control group after the intervention. In these previously sedentary, otherwise healthy, middle-aged adults, 2 years of high-intensity exercise training improved integrated cardiovascular regulation by enhancing the dynamic Starling mechanism and arterial-cardiac baroreflex sensitivity. ABSTRACT: Assessing the effects of exercise training on cardiovascular variability is challenging because of the complexity of multiple mechanisms. In a prospective, parallel-group, randomized controlled study, we examined the effect of 2 years of high-intensity exercise training on integrated cardiovascular function, which incorporates the dynamic Starling mechanism, dynamic arterial elastance and arterial-cardiac baroreflex function. Sixty-one healthy participants (48% male, aged 53 years, range 52-54 years) were randomized to either 2 years of exercise training (exercise group: n = 34) or control/yoga group (controls: n = 27). Before and after 2 years, subjects underwent a 6 min recording of beat-by-beat pulmonary artery diastolic pressure (PAD), stroke volume index (SV index), systolic blood pressure (sBP) and RR interval measurements with controlled respiration at 0.2 Hz. The dynamic Starling mechanism, dynamic arterial elastance and arterial-cardiac baroreflex function were calculated by transfer function gain between PAD and SV index; SV index and sBP; and sBP and RR interval, respectively. Fifty-three participants (controls: n = 25; exercise group: n = 28) completed the intervention. After 2 years, the dynamic Starling mechanism gain (Group × Time interaction: P = 0.008) and the arterial-cardiac baroreflex gain (P = 0.005) were significantly increased in the exercise group but remained unchanged in the controls. There was no change in dynamic arterial elastance in either of the two groups. The integrated cardiovascular function gain in the exercise group increased 1.34-fold, whereas there was no change in the controls (P = 0.02). In these previously sedentary, otherwise healthy middle-aged adults, a 2 year programme of high-intensity exercise training improved integrated cardiovascular regulation by enhancing the dynamic Starling mechanism and arterial-cardiac baroreflex sensitivity, without changing dynamic arterial elastance..
11. Hieda M, Howden E, Shibata S, Fujimoto N, Bhella PS, Hastings JL, Tarumi T, Satyam S, Fu Q, Zhang R, Levine BD, Impact of Lifelong Exercise Training Dose on Ventricular-Arterial Coupling., Circulation, 10.1161/CIRCULATIONAHA.118.035116, 138, 23, 2638-2647, 2018.12, BACKGROUND: The dynamic Starling mechanism, as assessed by beat-by-beat changes in stroke volume and left ventricular end-diastolic pressure, reflects ventricular-arterial coupling. It deteriorates with age, and is preserved in highly trained masters athletes. Currently, it remains unclear how much exercise over a lifetime is necessary to preserve efficient ventricular-arterial coupling. The purpose of this study was to assess the dose-dependent relationship between lifelong exercise training and the dynamic Starling mechanism in healthy seniors. METHODS: One hundred two seniors were recruited and stratified into 4 groups based on 25 years of exercise training history: sedentary subjects (n=27,
12. Hieda M, Yoo JK, Sun D, Okada Y, Parker R, Roberts-Reeves M, Adams-Huet B, Nelson D, Levine DB, and Fu Q, Time Course of Changes in Maternal Left Ventricular Function during Subsequent Pregnancy in Women with a History of Gestational Hypertensive Disorders., American Journal of Physiology-Regulatory, Integrativeand and Comparative Physiology, 10.1152/ajpregu.00040.2018, 315, 4, 587-594, 2018.10.
13. Hieda M, Parker J, Rajabi T, Fujimoto N, Bhella PS, Prasad A, Hastings JL, Sarma S, Levine BD, Left Ventricular Volume-Time Relation in Patients With Heart Failure With Preserved Ejection Fraction., Am J Cardiol, 10.1016/j.amjcard.2017.11.033, 121, 5, 609-614, 2018.03.
14. Hieda M; Howden E; Shibata S; Tarumi T; Lawley J; Hearon C Jr.; Palmer D; Fu Q; Zhang R; Sarma S; Benjamin D. Levine, Pre-load Corrected Dynamic Starling Mechanism in Patients with Heart Failure with Preserved Ejection Fraction., Journal of Applied Physiology, 10.1152/japplphysiol.00718.2017, 124, 1, 76-82, 2018.01, The beat-to-beat dynamic Starling mechanism (DSM), the dynamic modulation of stroke volume (SV) because of breath-by-breath changes in left-ventricular end-diastolic pressure (LVEDP), reflects ventricular-arterial coupling. The purpose of this study was to test whether the LVEDP-SV relationship remained impaired in heart failure with preserved ejection fraction (HFpEF) patients after normalization of LVEDP. Right heart catheterization and model-flow analysis of the arterial pressure waveform were performed while preload was manipulated using lower-body negative pressure to alter LVEDP. The DSM was compared at similar levels of LVEDP between HFpEF patients ( n = 10) and age-matched healthy controls ( n = 12) (HFpEF vs. CONTROLS: 10.9 ± 3.8 vs. 11.2 ± 1.3 mmHg, P = 1.00). Transfer function analysis between diastolic pulmonary artery pressure (PAD) representing dynamic changes in LVEDP vs. SV index was applied to obtain gain and coherence of the DSM. The DSM gain was significantly lower in HFpEF patients than in the controls, even at a similar level of LVEDP (0.46 ± 0.19 vs. 0.99 ± 0.39 ml·m-2·mmHg-1, P = 0.0018). Moreover, the power spectral density of PAD, the input variability, was greater in the HFpEF group than the controls (0.75 ± 0.38 vs. 0.28 ± 0.26 mmHg2, P = 0.01). Conversely, the power spectral density of SV index, the output variability, was not different between the groups ( P = 0.97). There was no difference in the coherence, which confirms the reliability of the linear transfer function between the two groups (0.71 ± 0.13 vs. 0.77 ± 0.19, P = 0.87). The DSM gain in HFpEF patients is impaired compared with age-matched controls even at a similar level of LVEDP, which may reflect intrinsic LV diastolic dysfunction and incompetence of ventricular-arterial coupling. NEW & NOTEWORTHY The beat-to-beat dynamic Starling mechanism (DSM), the dynamic modulation of stroke volume because of breath-by-breath changes in left-ventricular end-diastolic pressure (LVEDP), reflects ventricular-arterial coupling. Although the DSM gain is impaired in heart failure with preserved ejection fraction (HFpEF) patients, it is not clear whether this is because of higher LVEDP or left-ventricular diastolic dysfunction. The DSM gain in HFpEF patients is severely impaired, even at a similar level of LVEDP, which may reflect intrinsic left-ventricular diastolic dysfunction..
15. Hieda M, Seguchi O, Mutara Y, Sunami H, Sato T, Yanase M, Hiroki H, Fujita T, Nakatani T, Acute response test to adaptive servo-ventilation, a possible modality to assessing the reversibility of pulmonary vascular resistance., J Artif Organs, 10.1007/s10047-015-0833-1, 18, 3, 280-283, 2015.09.
16. Hieda M, Sata M, Nakatani T, The Importance of the Management of Infectious Complications for Patients with Left Ventricular Assist Device., Healthcare, 10.3390/healthcare3030750, 3, 3, 750-756, 2015.08.
17. Hieda M, Sata M, Seguchi O, Yanase M, Murata Y, Sato T, Sunami H, Nakajima S, Watanabe T, Hori Y, Wada K, Hata H, Fujita T, Kobayashi J, Nakatani T, Importance of Early Appropriate Intervention including Antibiotics and Wound care for Device-related Infection in Patients with Left Ventricular Assist Device., Transplant Proc, 10.1016/j.transproceed.2013.11.106, 46, 3, 907-910, 2014.04.
Presentations
 Show All Presentations >>
1. Hieda M, Sarma S, Hearon C, Dias K, MacNamara J, Palmer D, Martinez J, Samels M, Everding B, Livingston AS, Morris M, Levine DB, 1-year High-intensity Exercise Training Reverses Abnormal Left Ventricular Myocardial Stiffness in Patients With Stage B HFpEF., AHA 2019, 2019.11.
2. Hieda M, Yasuno S, Nagaya N, Takaki H, Goto Y, Exercise-Induced Disproportionate Elevation of Left Ventricular End-Diastolic Pressure vs Pulmonary Artery Diastolic Pressure is Associated With Exercise Intolerance After Myocardial Infarction., AHA 2019, 2019.11.
3. Hieda M, Sarma S, Hearon CM Jr, Dias KA, Palmer D, Martinez J, Samels M, Everding B, Livingston S, Morris M, Levine BD, Sub-clinical Impaired Ventricular-Arterial Coupling In Patients with Left Ventricular Hypertrophy plus Elevated Biomarkers, ACC2019, 2019.03.
4. Hieda M, Sarma S, Hearon CM Jr, Dias KA, Erin H, Palmer D, Martinez J, Samels M, Everding B, Livingston S, Morris M, Levine BD, Patients With Left Ventricular Hypertrophy and Elevated Biomarkers Have Greater Intrinsic Myocardial Stiffness Than Healthy-Controls., AHA 2018, 2018.11.
5. Hieda M, Sarma S, Aiad N, Kawalsky J, Hearon CM Jr., Erin H, Palmer D, Samels M, Everding B, Livingston S, and Levine BD, The Impact of 2-Years of High-Intensity Exercise Training on Left Atrial Function Using High-Resolution Waveform Analysis of Pulmonary Capillary Wedge Pressure Pressure., AHA 2018, 2018.11.
6. Hieda M, Howden E, Sarma S, Cornwell W, Tarumi T, Lawley J, Fu Q, Zhang R, Benjamin D.Levine, The Impact of 2-years High Intensity Exercise Training on Integrative Cardiovascular Regulation: Ventricular-Arterial Coupling, Dynamic Arterial Elastance, and Arterial-Cardiac Baroreflex Function., ACC2018, 2018.03.
7. Hieda M, Sarma S, Hearon C, Hardin A, Howden E and Levine BD, Left Ventricular Stiffness in Patients With Left Ventricular Hypertrophy is Not Different Compared to Healthy Controls., AHA2017, 2017.11.
8. Hieda M, Sarma S, Howden E, Tarumi T, Fu Q, Zhang R and Levine BD, High Intensity Exercise Training Improves Ventricular-Arterial Coupling., AHA2017, 2017.11.
9. Hieda M, Satyam S, Hearon C Jr., Lawley J, Hardin A, Samels M, Diaz J, Everding B, Palmer D, Hicklen L, Morris M, Livingston S, Yoo J, Fu Q, Zhang R, Benjamin D. Levine, PeakVO2-Cardiac Output Relationship during Exercise in Seniors who are Sedentary, Athletic, and HFpEF Patients, ACSM2017, 2017.05.
10. Hieda M, Howden E, Satyam S, Lawley J, Tarumi T, Bhella P, Hastings J, Fujimoto N, Shibata S, Palmer D, Lawley J, Hearon C Jr., Hardin A, Fu Q, Zhang R, Benjamin D. Levine, MD, The Impact of Lifelong Exercise Training “Dose” on the Ventricular-Arterial Coupling., ACC 2017, 2017.03.
11. Hieda M, Howden E, Lawley J, Satyam S,Stoller D ，Urey T，Tarumi T, Shibata S,Qi Fu ,Palmer D, Zhang R, Benjamin D. Levine, Dynamic Starling Mechanism is Impaired in Patients with Heart Failure with Preserved Ejection Fraction Compared with Age-matched Seniors, Even at Similar Left Ventricular End Diastolic Pressure., AHA2016, 2016.11.
12. Hieda M, Yasuno S, Nagaya N, Fujiwara R, Kumasaka R, Arakawa T, Nakanishi M, Takaki H, Goto Y, Cardiac Rehabilitation improved PeakVO2 regardless of Remarkable Rising of Left Ventricular End-Diastolic Pressure during Exercise in the Patients following Acute Myocardial Infarction., JCS 2015, 2015.04.
13. Hieda M, Yasuno S, Nagaya N, Takaki H, Goto Y, Reduced Exercise Capacity Attributable to Latent Left Ventricular Diastolic Dysfunction Unmasked by Invasive Exercise Testing in Diabetic Patients after Acute Myocardial Infarction., AHA2014, 2014.11.
14. Hieda M, Murata Y, Sato T, Watanabe T, Sunami, Seguchi O, Yanase , Nakatani T, Acute Effects of Adaptive Servo-ventilation on Hemodynamics in Advanced Chronic
Heart Failure Patients., HFSA 2013, 2013.09.
15. Hieda M, Murata Y, Sato T, Watanabe T, Sunami, Seguchi O, Yanase , Nakatani T, The Importance of Early and Appropriate Intervention to Device-related Infection in the Patients with Left Ventricular Assist System., CAST2013, 2013.09.
16. Hieda M, Murata Y, Yanase M, Seguchi O, Sunami H, Sato T, Watanabe T, Nakajima S, Nakatani T, The Effects of Adaptive Servo-ventilation on Hemodynamics in Advanced Chronic Heart Failure Patients., JCC2013, 2013.09.
17. Hieda M, Murata Y, Yanase M, Seguchi O, Sato T, Sunami H, Watanabe T, Shishido T, Nakatani T, Acute Effects of Adaptive Servo-ventilation on Hemodynamics in Advanced Chronic Heart Failure Patients, ESC2013, 2013.08.
18. Hieda M, Sata M, Seguchi O, Yanase M, Murata Y, Sato T, Sunami H, Nakajima S, Watanabe T, Hori Y, Wada K, Hata H, Fujita T, Kobayashi J, Nakatani T, The Importance of Early and Appropriate Intervention to Device-related Infection in the Patients with Left Ventricular Assist System., JCS2013, 2013.03.
19. Hieda M, The effects and future of ASV in patients with advanced heart failure., JHFS2012, 2012.11.
20. Hieda M, The effects and future of ASV in patients with advanced heart failure., Congress of Kinki Association for Clinical Engineering Technologists 2012, 2012.10.
21. Hieda M, Murata Y, Yanase M, Seguchi O, Sunami H, Sato T, Watanabe T, Nakatani T, The cerebrovascular events in patients with left ventricular assist device., The Japan Society of Embolus Detection and Treatment 2012, 2012.10.
22. Hieda M, Arita T, Nobuyoshi M, The treatment of the patient with severe systolic dysfunction and severe mitral regurgitation., JSE2012, 2012.04.
23. Hieda M, Arita T, Ando K, Iwabuchi M, Yokoi Y, Nobuyoshi M, Effects of Adaptive Servo Ventilation (ASV) in Patients with Advanced Chronic Heart Failure., ACC2012, 2012.03.
24. Hieda M, Murata Y, Yanase M, Seguchi O, Sunami H, Sato T, Watanabe T, Nakajima S, Nakatani T., Effects of Adaptive Servo Ventilation in Patients with Advanced Chronic Heart Failure., JCS2012, 2012.03.
25. Hieda M, Arita T, Domei T, Kato M, Ando K, Nobuyoshi M, Primary malignant mesothelioma presenting as ventricular containment following apical ballooning syndrome., JHFS2011, 2011.10.
26. Hieda M, Enomoto S, Kato M, Yamaji K, Shirai S, Ando K, Iwabuchi M, Nosaka H, Nobuyoshi M, Mid-Term Angiographic and Clinical Outcomes of Everolimus-Eluting Stent in Patients with Chronic Kidney Disease (CKD)., CVIT2011, 2011.07.
27. Hieda M, Kondo K, Urakawa T, Domei T, Kato M, Tokuda Y, Hiwatashi A, Yamaji K, Ando K, Arita T, Sakai K, Shirai S, Iwabuchi M, Yokoi H, Nosaka H, Nobuyoshi M, A Case of Successful Intravasular Ultrasound Guided Percutaneous Coronary Intervention for spiral dissection., CVIT2010, 2010.08.
28. Hieda M, Kato M, Enomoto S, Yamaji K, Shirai S, Ando K, Iwabuchi M, Nosaka H, Nobuyoshi M, Long-term clinical and angiographic outcomes after Paclitaxel eluting stent implantation., JCS2011.
Membership in Academic Society
  • Japanese Society of Internal Medicine
  • Japanese Circulation Society
  • Japan Society of Transplantation
  • Japanese Cardiac Rehabilitation Society
  • Japanese Society of Biorheology
  • American Heart Association
  • American College of Cardiology
  • European Society of Cardiology
Educational
Educational Activities
School of Medicine, Grade 6th, Mentor for Clinical Clerkship
School of Medicine, Grade 5th, Mentor for Clinical Clerkship
School of Medicine, Grade 3rd, Mentor for Clinical Clerkship


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