Kyushu University [Takanari Kitazono (Professor) Faculty of Medical Sciences, Department of Clinical Medicine]

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Researcher information

Takanari Kitazono
Professor
Internal Medicine
Department of Clinical Medicine
Faculty of Medical Sciences
Last modified date：2024.04.10

Graduate School

Department of Medicine and Surgery
Graduate School of Medical Sciences

Undergraduate School

Department of Medicine
School of Medicine

Other Organization

Center for Cohort Studies
Department of Nephrology,Hypertension,and Strokology
Department of Gastroenterology
Kidney Care Unit

Administration Post

Other

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Academic Degree

Country of degree conferring institution (Overseas)

Field of Specialization

Total Priod of education and research career in the foreign country

Outline Activities

Research

Educational

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1.	Ago T, Kuroda J, Kamouchi M, Sadoshima J, Kitazono T., Pathological roles of NADPH oxidase-nox family proteins in the vascular system., 2011.07.
2.	Kamouchi M, Ago T, Kitazono T., Brain pericytes: emerging concepts and functional roles in brain homeostasis., Cell Mol Neurobiol, 31: 175-193, 2011.03.

1.	Matsuo R, Yamaguchi Y, Matsushita T, Hata J, Kiyuna F, Fukuda K, Wakisaka Y, Kuroda J, Ago T, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators, Association Between Onset-to-Door Time and Clinical Outcomes After Ischemic Stroke., Stroke, 48, 11, 3049-3056, 48(11):3049-3056, 2017.11.
2.	Oishi E, Ohara T, Sakata S, Fukuhara M, Hata J, Yoshida D, Shibata M, Ohtsubo T, Kitazono T, Kiyohara Y, Ninomiya T, Day-to-Day Blood Pressure Variability and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study., Circulation, 136, 6, 516-525, 136(6):516-525, 2017.08.
3.	Tachibana M, Ago T, Wakisaka Y, Kuroda J, Shijo M, Yoshikawa Y, Komori M, Nishimura A, Makihara N, Nakamura K, Kitazono T, Early Reperfusion After Brain Ischemia Has Beneficial Effects Beyond Rescuing Neurons., Stroke, 48, 8, 2222-2230, 48(8):2222-2230, 2017.08.
4.	Seki T, Goto K, Kiyohara K, Kansui Y, Murakami N, Haga Y, Ohtsubo T, Matsumura K, Kitazono T, Downregulation of Endothelial Transient Receptor Potential Vanilloid Type 4 Channel and Small-Conductance of Ca2+-Activated K+ Channels Underpins Impaired Endothelium-Dependent Hyperpolarization in Hypertension., Hypertension, 69, 1, 143-153, 2017.01.
5.	Matsuo R, Michikawa T, Ueda K, Ago T, Nitta H, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators, Short-Term Exposure to Fine Particulate Matter and Risk of Ischemic Stroke., Stroke, 47, 12, 3032-3034, 2016.12.
6.	Eriguchi M, Tsuruya K, Haruyama N, Yamada S, Tanaka S, Suehiro T, Noguchi H, Masutani K, Torisu K, Kitazono T, Renal denervation has blood pressure-independent protective effects on kidney and heart in a rat model of chronic kidney disease., Kidney Int, 87, 116-127, 2015.01.
7.	Ishitsuka K, Kamouchi M, Hata J, Fukuda K, Matsuo R, Kuroda J, Ago T, Kuwashiro T, Sugimori H, Nakane H, Kitazono T; FSR Investigators, High blood pressure after acute ischemic stroke is associated with poor clinical outcomes: Fukuoka Stroke Registry., Hypertension, 63, 54-60, 2014.01.
8.	Nakamura A, Ago T, Kamouchi M, Hata J, Matsuo R, Kuroda J, Kuwashiro T, Sugimori H, Kitazono T; Fukuoka Stroke Registry Investigators, Intensity of anticoagulation and clinical outcomes in acute cardioembolic stroke: the Fukuoka Stroke Registry., Stroke, 44, 3239-3242, 2013.11.
9.	Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y, Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009)., Circulation, 128, 1198-1205, 2013.09.
10.	Nakano T, Ninomiya T, Sumiyoshi S, Onimaru M, Fujii H, Itabe H, Nakashima Y, Sueishi K, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y, Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders: results from the Hisayama Study., Kidey Int, 84, 373-380, 2013.08.
11.	Nakamura K, Kamouchi M, Arimura K, Nishimura A, Kuroda J, Ishitsuka K, Tokami H, Sugimori H, Ago T, Kitazono T, Extracellular acidification activates cAMP responsive element binding protein via Na+/H+ exchanger isoform 1-mediated Ca2+ oscillation in central nervous system pericytes., Arterioscler Thromb Vasc Biol, 32, 2670-2677, 2012.11.
12.	Kumai Y, Kamouchi M, Hata J, Ago T, Kitayama J, Nakane H, Sugimori H, Kitazono T, for the FSR Investigators, Proteinuria and clinical outcomes after ischemic stroke., Neurology, 78, 1909-1915, 2012.06.
13.	Shichita T, Hasegawa E, Kimura A, Morita R, Sakaguchi R, Takada I, Sekiya T, Ooboshi H, Kitazono T, Yanagawa T, Ishii T, Takahashi H, Mori S, Nishibori M, Kuroda K, Akira S, Miyake K, Yoshimura A, Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain., Nat Med, 18, 911-918, 2012.06.
14.	Arimura K, Ago T, Kamouchi M, Nakamura K, Ishitsuka K, Kuroda J, Sugimori H, Ooboshi H, Sasaki T, Kitazono T., PDGF receptor β signaling in pericytes following ischemic brain injury., Cur Neurovasc Res, 9, 1-9, 2012.02.
15.	Yamada S, Taniguchi M, Tokumoto M, Toyonaga J, Fujisaki K, Suehiro T, Noguchi H, Iida M, Tsuruya K, Kitazono T., The antioxidant tempol ameliorates arterial medial calcification in uremic rats: important role of oxidative stress in the pathogenisis of vascular calcification in chronic kidney disease., J Bone Miner Res, 27, 2, 474-485, 2012.02.
16.	Kamouchi M, Matsuki T, Hata J, Kuwashiro T, Ago T, Sambongi Y, Fukushima Y, Sugimori H, Kitazono T; for the FSR investigators., Prestroke glycemic control is associated with the functional outcome in acute ischemic stroke: the Fukuoka Stroke Registry., Stroke, 42, 2788-2794, 2011.10.
17.	Matsushita T, Ashikawa K, Yonemoto K, Hirakawa Y, Hata J, Amitani H, Doi Y, Ninomiya T, Kitaozono T, Ibayashi S, Iida M, Nakamura Y, Kiyohara Y, Kubo M., Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke., Hum Mol Genet, 19, 6, 1137-1146, 2010.03.
18.	Nakamura K, Kamouchi M, Kitazono T, Kuroda J, Matsuo R, Hagiwara N, Ishikawa E, Ooboshi H, Ibayashi S, Iida M, Role of NHE1 in calcium signaling and cell proliferation in human CNS pericytes, American Journal of Physiology, 294: H1700-H1707, 2008.04.
19.	Kuroda J, Kitazono T, Ago T, Ninomiya T, Ooboshi H, Kamouchi M, Kumai Y, Hagiwara N, Yoshimura S, Tamaki K, Kusuda K, Fujii K, Nagao T, Okada Y, Toyoda K, Nakane H, Sugimori H, Yamashita Y, Wakugawa Y, Asano K, Tanizaki Y, Kiyohada Y, Ibayashi S, Iida M, NAD(P)H oxidase p22phox C242T polymorphism and ischemic stroke in Japan: the Fukuoka Stroke Registry and the Hisayama Study, European Journal of Neurology, 14: 12-16, 2007.10.
20.	Kubo M, Hata J, Ninomiya T, Matsuda K, Yonemoto K, Nakano T, Matsushita T, Yamazaki K, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Sueishi K, Iida M, Nakamura Y, Kiyohara Y., A nonsynonymous SNP IN PRKCH (protein kinase Cη) increases the risk of cerebral infarction., Nat Genet, 39, 2, 212-217, 2007.02.
21.	Ago T, Kitazono T, Kuroda J, Kumai Y, Kamouchi M, Ooboshi H, Wakisaka M, Kawahara T, Rokutan K, Ibayashi S, Iida M., NAD(P)H oxidases in rat basilar arterial endothelial cells., Stroke, 10.1161/01.STR.0000163111.05825.0b, 36, 5, 1040-1046, 2005.05.
22.	Ago, T., Kitazono, T., Ooboshi, H., Matsuo, R., Takada, J., Wakisaka, M., Ibayashi, S., Iida, M, NOX4 as the major catalytic component of an endothelial NAD(P)H oxidase., Circuration, 10.1161/01.CIR.0000105680.92873.70, 109, 2, 227-233, 109: 227-233, 2004.01.
23.	Kitazono, T., Ago, T., Kamouchi, M., Santa, N., Ooboshi, H., Fujishima, M., Ibayashi, S., Increased activity of calcium channels and Rho-associated kinase in the basilar artery during chronic hypertension in vivo., Journal of Hypertension, 10.1097/00004872-200205000-00022, 20, 5, 879-884, 20: 879-884, 2002.01.
24.	Wakisaka, M., Kitazono, T., Kato, M., Nakamura, U., Yoshioka, M., Uchizono, Y., Yoshinari, M., Sodium-coupled glucose transporter as a functional glucose sensor of retinal microvascular circulation., Circulation Research, 10.1161/hh1101.091265, 88, 11, 1183-1188, 88 1183-1188, 2001.01.
25.	Kitayama, J., Kitazono, T., Ibayashi, S., Nagao, T., Wakisaka, M., Watanabe, Y., Fujishima, M., Role of phosphatidylinositol 3-kinase in acetylcholine-induced dilatation of rat basilar artery in vivo., Stroke, 31, 10, 2487-2492, 31: 2487-2493, 2000.01.
26.	Kitazono, T., Ibayashi, S., Nagao, T., Fujii, K., Kagiyama, T., Fujishima, M., Role of tyrosine kinase in dilator responses of the basilar artery in vivo., Hypertension, 31, 3, 861-865, 31: 861-865, 1998.01.
27.	Taguchi, H., Heistad, D.D., Kitazono, T., Faraci, F.M., Dilatation of cerebral arterioles in response to activation of adenylate cyclase is dependent on activation of Ca2+-dependent K+ channels., Circulation Research, 76: 1057-1062, 1995.01.
28.	Taguchi, H., Faraci, F.M., Kitazono, T., Heistad, D.D., Relaxation of the aorta during hypertension is impaired in chronically hypertensive rats., Hypertension, 25: 735-738, 1995.01.
29.	Kitazono, T., Heistad, D.D., Faraci, F.M., Enhanced responses of the basilar artery to activation of endothelin B receptors in stroke-prone spontaneously hypertensive rats., Hypertension, 25: 490-494, 1995.01.
30.	Kitazono, T., Padgett, R.C., Armstrong, M.L., Tompkins, P.K., Heistad, D.D., Evidence that angiotensin II is present in human monocytes., Circulation, 91: 1129-1134, 1995.01.
31.	Taguchi H, Heistad DD, Kitazono T, Faraci FM, ATP-sensitive K+ channels mediate dilatation of cerebral arterioles during hypoxia., Circulation Research, 74: 1005-1008, 1994.01.
32.	Kitazono, T., Heistad, D.D., Faraci, F.M., ATP-sensitive potassium channels in the basilar artery during chronic hypertension., Hypertension, 22: 677-681, 1993.01.
33.	Kitazono, T., Heistad, D.D., Faraci, F.M., Role of ATP-sensitive K+ channels in CGRP-induced dilatation of the basilar artery in vivo., American Journal of Physiology, 265: H581-H585, 1993.01.
34.	Kitazono, T., Faraci, F.M., Heistad, D.D., Effect of norepinephrine on rat basilar artery in vivo., American Journal of Physiology, 264: H178-H182, 1993.01.
35.	Kitazono, T., Takeshige, K., Cragoe, E.J., Jr., Minakami, S., Intracellular pH changes of cultured bovine aortic endothelial cells in response to ATP addition., Biochemical and Biophysical Research Communication, 10.1016/S0006-291X(88)80427-3, 152, 3, 1304-1309, 152: 1304-1309, 1988.01.

1.	Hypertension and chronic kidney disease (CKD) in acute stroke patients; the Fukuoka Stroke Registry.
2.	Molecular epidemiology of cerebrovascular disease; The Hisayama Study and the Fukuoka Stroke Registry (FSR).