Tomoharu Yoshizumi
Professor
Department of Surgery and Science
Department of Clinical Medicine
Faculty of Medical Sciences
Last modified date：2024.04.09
Transplant surgery, Hepato-biliary-pancreatic surgery, Gastroenterological surgery
How to over come the small for size graft syndrome after living donor liver transplantation
Treatment for recurrent hepatitis C after living donor liver transplantation
Impact of simultaneous splenectomy in living donor liver transplantation
Research Interests
- Splenectomy in living donor liver transplantation
keyword : Splenectomy, Small for size graft syndrome
2018.04～2020.12.
- HBV vaccination after liver transplantation
keyword : HBV vaccination liver transplantation
2017.04～2021.03.
- Living donor liver transplantation using donor older than 60 years of age
keyword : Living donor liver transplantation
2015.04～2019.03.
- Variants in the HLA-DP locus is associated with the effect of HBV vaccination after living donor liver transplantation
keyword : Hepatitis type B, HLA-DP
2014.04～2019.12.
- Immunosuppression therapy for renal dysfunction after living donor liver transplantation
keyword : living donor liver transplantation, renal dysfunction, mycophenolate mofetyl
2011.05～2014.03.
- Impact of simultaneous splenectomy in living donor liver transplantation
keyword : living donor liver transplantation, splenectomy, small-for-size graft syndrome
2010.04～2022.03.
- Impact of splenectomy in immunological response in patients undergone living donor liver transplantation
keyword : Regulatory T cell、Fox P3、Splenectomy、Liver Transplantation
2007.04～2007.12Immunological responce after living donor liver transplantation for the patients with hepatocellular carcinoma has not been studied yet. .
- Small-for-size graft in living donor liver transplantation
keyword : Small-for-size graft, Liver transplantation
2002.01～2011.03.
Academic Activities
Reports
| 1. |
Tomoharu Yoshizumi and Masaki Mori, Portal flow modulation in living donor liver transplantation: review with a focus on splenectomy., Surgery Today, 10.1007/s00595-019-01881-y. , 2019.12, Small-for-size graft (SFSG) syndrome after living donor liver transplantation (LDLT) is the dysfunction of a small graft, characterized by coagulopathy, cholestasis, ascites, and encephalopathy. It is a serious complication of LDLT and usually triggered by excessive portal flow transmitted to the allograft in the postperfusion setting, resulting in sinusoidal congestion and hemorrhage. Portal overflow injures the liver directly through nutrient excess, endothelial activation, and sinusoidal shear stress; and indirectly through arterial vasoconstriction. These conditions may be attenuated with portal flow modulation. Attempts have been made to control excessive portal flow to the SFSG, including simultaneous splenectomy, splenic artery ligation, hemi-portocaval shunt, and pharmacological manipulation, with positive outcomes. Currently, a donor liver is considered a SFSG when the graft-to-recipient weight ratio is less than 0.8 or the ratio of the graft volume to the standard liver volume is less than 40%. A strategy for transplanting SFSG safely into recipients and avoiding extensive surgery in the living donor could effectively address the donor shortage. We review the literature and assess our current knowledge of and strategies for portal flow modulation in LDLT.. |
Papers
| 1. |
Yoshizumi T, Itoh S, Shimokawa M, Inokuchi S, Harada N, Takeishi K, Mano Y, Yoshiya S, Kurihara T, Nagao Y, Ikegami T, Soejima Y, Mori M., Simultaneous splenectomy improves outcomes after adult living donor liver transplantation., Journal of Hepatology, 10.1016/j.jhep.2020.08.017. , 74, 2, 372-379, 2021.02. |
| 2. |
Yoshizumi T, Taketomi A, Uchiyama H, Harada N, Kayashima H, Yamashita Y, Soejima Y, Shimada M, Maehara Y. , Graft size, donor, age, and patient status are the indicators of early graft function after living donor liver transplantation. , Liver Transplantation, 14, 7, 1007-1013, 2008.07. |
Presentations
| 1. |
Tomoharu Yoshizumi, Masaki Mori, Challenges in the Selection of Marginal Donors in Living Donor Liver Transplantation, 14th World Congress of the IHPBA, 2020.09. |
Membership in Academic Society
- American society of transplant surgeons
- Japan Surgical Society
- Japanese Society of Gastroenterological Surgery
- The Transplantation Society
- International Liver Transplant Society
- The Japan Society of Hepatology
- Japanese Society of Hepato-biliary-pancreatic surgery
- Japan Biliary Association
- Japanese Society of Gastroenterology
- Japan Society of Clinical Oncology
- The japan Society for Transplantation
- Japan Surgical Association
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Educational Activities
I was working as one of the support staff members for clinical resident and Medical student at Kyushu University hospital. I am also teaching 5th an 6th grade medical student at bed side.
Professional and Outreach Activities
Technical advise at Ibun Sina Hospital in Sudan and Support living donor liver Transplantation in Myanmar.
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