https://kyushu-u.elsevierpure.com/en/persons/makoto-kubo
　Reseacher Profiling Tool　Kyushu University Pure

http://www.med.kyushu-u.ac.jp/surgery1

MD, PhD

No

Breast surgery and oncology

02years00months

We perform medical examination and treatment (diagnosis / surgery / oncological treatment, etc.) for the patient with breast cancer and conduct translational research about the breast cancer from the approach of surgical and clinical oncology. Also, we try to upbring the specialists for the sake of corresponding to the rapid increase of patients with breast cancer. Moreover, we opened a public lecture and attend at the patients' associations, and we are consulted and work on enlightenment.

Research Interests

• Elucidation of the immune system in breast cancer microenvironment
  keyword : breast cancer microenvironment
  2023.02～2025.12.
• Validation of dense breast
  keyword : Dense breast
  2021.04～2026.03.
• Internationalization of check-up for breast cancer
  keyword : check-up for breast cancer, mammography
  2020.03～2025.03.
• Pathological biomarkers diagnosis in breast cancer using artificial intelligence
  keyword : AI
  2019.06～2022.03.
• Diagnosis and monitoring for treatment with using cell free DNA
  keyword : Cell free DNA
  2019.01～2024.12.
• Cancer genome medicine
  keyword : Cancer genome medicine
  2018.04～2021.03.
• The combination of PD-L1 expression and decreased tumor-infiltrating lymphocytes is associated with a poor prognosis in triple-negative breast cancer.
  keyword : PD-L1
  2015.06～2017.06.
• BRCAness in triple negative breast cancer
  keyword : BRCAness
  2014.04～2016.05.
• Hereditary Breast and Ovarian Cancer Syndrome
  keyword : Hereditary Breast Cancer
  2013.04～2014.05.
• １．Breast Cancer Stem Cells
  ２．Gene Profiling of Breast Cancer
  ３．Endoscopic Breast Surgery
  keyword : Breast cancer
  2003.09～2014.121. We sort CD24-/lowCD44+ cells as stem-like cells of the breast cancer and analyze its signaling. Also, we investigate the therapeutic directionality of the drug-resistant or triple negative breast cancer by determining the characteristics of cancer stem cells. 2. We perform gene profiling of breast carcinomas using resected samples and store genetic samples . We analyze particularly juvenile breast cancers and make a base of the therapy choice. 3. We choose and produce devices to establish the methods of endoscopic surgery for patients with primary breast cancer. .

Current and Past Project

• Registry research on tumor mutation burden
• We promote AI (Artificial Intelligence) evaluation for high-density breasts and contribute to lower breast cancer mortality in young people.
• Our aim is to develop a prediction tool, TP53 signature.
• Our goal is to construct an examination system in Japan and analyze genetic mutations using multiｰplex panel examination, a comprehensive cancer-related gene analysis tool by NGS.
• Real practise and prognosis based on subtypes in breast cancer.
• We build the mutual and stable relationship between the two countries while applying the Internet technology.

Academic Activities
Membership in Academic Society

• Japan Association of Breast Cancer Screening
• Japanese Cancer Association
• Kyushu Associations of Surgery, Pediatric Surgery, and Endocrine Surgery
• Japan Society of Clinical Oncology
• Japan Breast Cancer Society
• Japan Surgical Society

Awards

• Target therapy for triple negative breast cancer
• Five programs provided scholarships designed to promote the education and professional development of early-career scientists who are
  actively pursuing research in breast cancer by facilitating their attendance at SABCS.
• Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer.

Educational Activities
Other Educational Activities

• 2021.03, Education for medical staff on Cancer Precision Medicine for affiliated hospitals.
• 2020.02, Precision Oncology Seminar.
• 2019.06, Education for medical staff on Cancer Precision Medicine..
• 2019.01, Precision Oncology Seminar.
• 2019.07.
• 2019.10.
• 2019.06.