Kyushu University [Hiroaki Niiro (Professor) Faculty of Medical Sciences, Department of Medical Education]

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Hiroaki Niiro
Professor
Department of Medical Education
Department of Medical Education
Faculty of Medical Sciences
Last modified date：2023.11.22

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Department of Medicine
Graduate School of Medical Sciences

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Research Interests

Role of T-bet+ effector B cells in autoimmune diseases
keyword : cytokine, effector B cells, autoimmune diseases, T-bet
2021.04.
Role of cytokine-producing effector B cells in autoimmune diseases
keyword : cytokine, effector B cells, autoimmune diseases
2018.04～2021.03.
Role of pathogenic effector and regulatory B cells in the pathogenesis of autoimmune diseases
keyword : effector B cells, regulatory B cells
2015.04～2018.03.
Elucidating the role of human regulatory B cells in autoimmune diseases
keyword : Breg autoimmune diseases
2013.04～2015.03.
Upon B-cell receptor (BCR) ligation by autoantigens, B cells normally undergo deletion (apoptosis), inactivation (anergy), or receptor editing. These processes are finely tuned by positive and negative signals downstream of B cell receptor (BCR)(Niiro and Clark. Nat. Rev. Immunol. 2002). Aberrant regulation of BCR signals may thus lead to activation and expansion of autoreactive B cells. B cell adaptor proteins function as molecular conduits to effectively link upstream signals to specific downstream branches. We are currently focusing on a novel adaptor protein that is critical for negative signals in B cells, and also on the involvement of this adaptor protein in the pathogenesis of autoimmune diseases.
keyword : B cell, signal transduction, adaptor protein, autoimmune disease, antigen receptor
2007.04～2013.03.

Academic Activities

Reports

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1.	Niiro H, and Clark EA, Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1, Immunity, 19:637-640, 2003.11.
2.	Niiro H, Clark EA, Regulation of B-cell fate by antigen-receptor signals, Nat Rev Immunol, 2:945-956, 2002.12.

Papers

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1.	Niiro H, Jabbarzadeh-Tabrizi S, Kikushige Y, Shima T, Noda K, Ota SI, Tsuzuki H, Inoue Y, Arinobu Y, Iwasaki H, Shimoda S, Baba E, Tsukamoto H, Horiuchi T, Taniyama T, and Akashi K, CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells., Blood, 119, 10, 2263-2273, 2012.03.
2.	Yoshimoto G, Miyamoto T, Jabbarzadeh-Tabrizi S, Iino T, Rocnik JL, Kikushige Y, Mori Y, Shima T, Iwasaki H, Takenaka K, Nagafuji K, Mizuno S-I, Niiro H, Gilliland GD, and Akashi K, FLT3-ITD upregulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation , Blood, 114, 24, 5034-5043, 2009.12.
3.	Jabbarzadeh-Tabrizi S, Niiro H, Masui M, Yoshimoto G, Iino T, Kikushige Y, Wakasaki T, Baba E, Shimoda S, Miyamoto T, Hara T, Akashi , T cell leukemia/lymphoma 1 and Galectin-1 regulate survival/cell death pathways in human naïve and IgM+ memory B cells through altering balances in Bcl-2 family proteins., J. Immunol, 182(3): 1490-1499, 2009.02.

Presentations

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1.	Kazuhiko Higashioka, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro, Pathologic role of activated SLAMF7+Tfh1 cells in facilitating IgG4 production by B cells in IgG4-related disease, 第63回日本リウマチ学会総会・学術集会, 2019.04.
2.	Kazuhiko Higashioka, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi and Hiroaki Niiro., A Novel B-Cell-Helper IL-21-Producing CD8+ T Cell Subset Involved in the Pathogenesis of Rheumatoid Arthritis, 2018 ACR/ARHP Annual Meeting, 2018.10.
3.	Kazuhiko Higashioka, Hiroaki Niiro, Yuri Ota, Tsuyoshi Nakayama, Koji Mishima, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Koichi Akashi, and Takahiko Horiuchi., Identification of IFN-γ-producing effector B cells in humans: relevance to the pathogenesis of systemic lupuserythematosus., Keystone Symposia Conference B Cells, 2018.06.
4.	Shun-ichiro Ota, Hiroaki Niiro, Naoko Ueki, Yuri Hirosaki, Hirofumi Tsuzuki, Kumiko Noda, JABBARZADEH TABRIZI SIAMAK, Atsushi Tanaka, Hiroki Mitoma, Yojiro Arinobu, Mitsuteru Akahoshi, Hiroshi Tsukamoto, Koichi Akashi, Elucidation of molecular mechanism of Breg induction in autoimmune diseases. , ACR annual meeting 2014, 2014.11.
5.	Yuri Hirosaki, Hiroaki Niiro, Shun-ichiro Ota, Naoko Ueki, Hirofumi Tsuzuki, JABBARZADEH TABRIZI SIAMAK, Kumiko Noda, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroshi Tsukamoto, Koichi Akashi, Pathogenic role of CXC chemokine receptor 3-positive B cells in bone destruction of rheumatoid arthritis., ACR annual meeting 2014, 2014.11.

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