| 1. |
Ryohei Maruoka, Mitsuru Esaki, Yosuke Minoda, Yoshihiro Otsuka, Kazuhiro Haraguchi, Haruei Ogino, Eikichi Ihara, Effective hemostasis with a self-assembling peptide hemostatic gel to manage leaky hemorrhage at the ulcer closure site after gastric endoscopic submucosal dissection., Endoscopy, 10.1055/a-2291-9050, Vol.56, No.S 01, p.E323-E324, 2024.12. |
| 2. |
Yusuke Suzuki, Mitsuru Esaki, Eikichi Ihara, Development of postoperative bleeding management in gastric endoscopic submucosal dissection., Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 10.1111/den.14744, 2024.01. |
| 3. |
Ryohei Maruoka, Mitsuru Esaki, Yosuke Minoda, Noriko Tokunaga, Kazuhiro Haraguchi, Eikichi Ihara, Yoshihiro Ogawa, Three-point traction method for endoscopic submucosal dissection using clip-with-thread and clip-with-silicon bands for large early gastric neoplasms., Endoscopy international open, 10.1055/a-2219-8130, Vol.12, No.1, p.E57-E58, 2024.01. |
| 4. |
Leonardo Yoshio Sato, Yoshitaka Hata, Mitsuru Esaki, Eikichi Ihara, Shiho Tajiri, Tomohiko Moriyama, Yosuke Minoda, Double-scope technique to recover from hand-suturing trouble in the duodenum., Endoscopy, 10.1055/a-2199-3398, Vol.55, No.S 01, p.E1193-E1194, 2023.12. |
| 5. |
Misato Esaki, Mitsuru Esaki, Kosuke Maehara, Yosuke Minoda, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa, Rubber band-assisted, one-person-operated cold snare polypectomy for colorectal polyps., Endoscopy international open, 10.1055/a-1576-7673, Vol.9, No.11, p.E1845-E1846, 2021.11. |
| 6. |
Takayuki Nasu, Mitsuru Esaki, Yoshihisa Shoguchi, Xiaopeng Bai, Yosuke Minoda, Haruei Ogino, Eikichi Ihara, Traction-assisted hybrid endoscopic submucosal dissection for small rectal neuroendocrine tumors., Endoscopy, 10.1055/a-1662-4965, 2021.11. |
| 7. |
Eikichi Ihara, Shohei Hamada, Kazumasa Muta, Masafumi Wada, Yoshitaka Hata, Hiroko Ikeda, Yoshimasa Tanaka, Haruei Ogino, Takatoshi Chinen, Yoshihiro Ogawa, USEFULNESS OF ONIGIRI ESOPHAGOGRAPHY COMBINED WITH AN OBSTRUCTION LEVEL CLASSIFICATION SYSTEM IN SCREENING ESOPHAGEAL MOTILITY DISORDERS, GASTROENTEROLOGY, Vol.160, No.6, pp.S648-S649, 2021.05. |
| 8. |
Mitsuru Esaki, Toshiki Horii, Ryoji Ichijima, Masafumi Wada, Seiichiro Sakisaka, Shuichi Abe, Naru Tomoeda, Yusuke Kitagawa, Kei Nishioka, Yosuke Minoda, Shinichi Tsuruta, Sho Suzuki, Hirotada Akiho, Eikichi Ihara, Yoshihiro Ogawa, Takuji Gotoda, Assistant skill in gastric endoscopic submucosal dissection using a clutch cutter., World journal of gastrointestinal surgery, 10.4240/wjgs.v13.i2.116, Vol.13, No.2, pp.116-126, 2021.02, BACKGROUND: A clutch cutter is a scissor-type knife used in endoscopic submucosal dissection (ESD) for gastrointestinal tract tumors. The assistant during the ESD using a clutch cutter (ESD-C) needs to rotate the device and grasp the target tissue appropriately; therefore, the assistant's skill may affect the technical outcomes of ESD-C. AIM: To determine how assistant skill level affected the technical outcomes of gastric ESD-C using an ex vivo porcine training model. METHODS: In this pilot study, mock lesions of 15-30 mm in diameter were created in the middle or lower third of the porcine stomach. A total of 32 ESD-C procedures were performed by 16 trainees. Each trainee operator performed two ESD-C procedures; one ESD-C was assisted by an expert (ESD-C-E), and the other was assisted by a non-expert (ESD-C-NE). The total procedure time of the ESD was set as the primary outcome, and en bloc resection rate, complete procedure rate, perforation rate, and each procedure time/speed for mucosal incision or submucosal dissection were set as the secondary outcomes. In addition, we investigated factors associated with the difficulty of ESD including incompletion of ESD procedure, a long procedure time (≥ 20 min) or intraoperative perforation. RESULTS: The median total procedure time of the ESD-C-E was significantly shorter than that of the ESD-C-NE (12.9 min vs 21.9 min, P = 0.001). The en bloc resection rate was 100% in both groups. Complete resection rates of the ESD-C-E and ESD-C-NE groups were 100% and 93.8%, respectively. No intraoperative perforation was observed in both groups. In the multivariate analysis, assistant skill was significantly associated with the difficulty of ESD, with the highest odds ratio of 16.5. CONCLUSION: Assistance by an expert is an important factor when trainees perform ESD-C procedures.. |
| 9. |
Shohei Hamada, Eikichi Ihara, Hiroko Ikeda, Kazumasa Muta, Haruei Ogino, Takatoshi Chinen, Yoshimasa Tanaka, Yoshihiro Ogawa, Clinical Characterization of Vonoprazan-Refractory Gastroesophageal Reflux Disease., Digestion, 10.1159/000503340, Vol.102, No.2, pp.197-204, 2021.02, INTRODUCTION: The newly developed vonoprazan (a potassium-competitive acid blocker) has a greater ability to suppress gastric acid production than convention proton pump inhibitors (PPIs). The objective of the present study was to determine how vonoprazan influences the pathogenesis of refractory gastroesophageal reflux disease (GERD) in clinical practice. METHODS: Between March 2013 and November 2018, a total of 73 refractory GERD patients (34 in the conventional PPI group versus 39 in the vonoprazan group) were enrolled in this retrospective study. We then compared the underlying disease conditions between the 2 groups, examined by high-resolution manometry and multichannel intraluminal impedance/pH (MII-pH) monitoring. RESULTS: There was a significant difference in the proportion of underlying disease conditions, including erosive esophagitis, non-erosive reflux disease, reflux hypersensitivity, functional heartburn and oesophageal motility disorder (EMD), between the conventional PPI (6, 14, 23, 40 and 17% respectively) and vonoprazan groups (0, 0, 10, 49, and 41% respectively; p |
| 10. |
Hiroaki Okuno, Haruei Ogino, Eikichi Ihara, Kei Nishioka, Yoshimasa Tanaka, Takatoshi Chinen, Motoyuki Kohjima, Takamasa Oono, Masatake Tanaka, Takeshi Goya, Nao Fujimori, Yoichiro Iboshi, Takuji Gotoda, Yoshihiro Ogawa, Discriminant equation using mucosally expressed cytokines and transcription factor for making definite diagnosis of inflammatory bowel disease unclassified., BMC gastroenterology, 10.1186/s12876-021-01656-1, Vol.21, No.1, p.73, 2021.02, BACKGROUND: The pathological conditions of UC and CD involved in inflammatory bowel disease-unclassified (IBD-U), UC with primary sclerosing cholangitis (PSC-UC), and UC with autoimmune pancreatitis type 2 (AIP-UC) remain unclear. Therefore, it is difficult to decide the appropriate treatments for these subtypes of UC. Our aim was to examine whether the discriminant equation using the mucosally expressed mediators designed as our previous study for IBD, could characterize IBD-U, PSC-UC, or AIP-UC. METHODS: A total of 56 patients including UC (n = 24), CD (n = 15), IBD-U (n = 10), PSC-UC (n = 4), and AIP-UC (n = 3), along with 9 control patients were enrolled in this study. Mucosally expressed inflammatory mediators related to Th1, Th2, Th17, and Treg were measured using quantitative PCR in endoscopic biopsies from the inflamed intestines of the patients. The IBD-U, PSC-UC or AIP-UC were characterized using discriminant analysis and principle component analysis. RESULTS: Through discriminant analyses, combinations of 3 to 7 inflammatory mediators were used to discriminate between UC and CD. Moreover, the identified 3 markers could diagnose patients with IBD-U as UC or CD with high accuracy. The distribution graph of inflammatory mediators using the principal component analysis revealed that PSC-UC and AIP-UC exhibited CD-like and UC-like features, respectively. CONCLUSIONS: The discriminant equation using mucosally expressed mediators of IL-13, IL-21 and T-bet can be used as a universal diagnostic tool not only for IBD-U but also to assess pathological conditions in PSC-UC and AIP-UC.. |
| 11. |
Nao Fujimori, Takashi Osoegawa, Akira Aso, Soichi Itaba, Yosuke Minoda, Masatoshi Murakami, Kazuhide Matsumoto, Katsuhito Teramatsu, Yu Takamatsu, Takehiro Takaoka, Takamasa Oono, Eikichi Ihara, Tomoharu Yoshizumi, Takao Ohtsuka, Masafumi Nakamura, Yoshihiro Ogawa, Efficacy of Early Endoscopic Ultrasound-Guided Transluminal Drainage for Postoperative Pancreatic Fistula., Canadian journal of gastroenterology & hepatology, 10.1155/2021/6691705, Vol.2021, p.6691705, 2021.01, Background: Endoscopic ultrasound-guided transluminal drainage (EUS-TD) is generally performed 4 weeks after disease onset for evacuating pancreatic fluid collections. However, the optimal timing for conducting the procedure in those diagnosed with postoperative pancreatic fistula (POPF) has not been established. We aimed to elucidate the efficacy and safety of early EUS-TD procedures for treating POPF. Methods: We retrospectively reviewed patients diagnosed with POPF who underwent EUS-TD in the Kyushu University Hospital between 2008 and 2019. Clinical features were comparatively analyzed between the two patient groups who underwent either early (≤15 days postoperatively) or late (>15 days postoperatively) EUS-TD. Factors prolonging hospital stay were also analyzed using Cox proportional hazard models. Results: Thirty patients (median age, 64.5 years) were enrolled. The most common initial operation was distal pancreatectomy with splenectomy (60.0%). Median size of POPF was 69.5 (range, 38-145) mm, and median time interval between surgery and EUS-TD was 17.5 (range, 3-232) days. Totally, 47% patients underwent early EUS-TD. Rates of technical success, clinical success, and complications were 100%, 97%, and 6.9%, respectively. No recurrence of POPF occurred during a median follow-up period of 14 months. Clinical characteristics and outcomes were comparable between the early and late drainage patient groups, except for the rates of infection and nonencapsulation of POPF, which were significantly higher in the early drainage group. Performing simultaneous internal and external drainage (hazard ratio (HR): 0.31; 95% confidence interval (CI): 0.11-0.93, p=0.04) and conducting ≥2 treatment sessions (HR: 0.26; 95% CI: 0.08-0.84, p=0.02) were significantly associated with prolonged hospitalization after EUS-TD. Conclusions: EUS-TD is a safe and effective method for managing POPF, regardless of when it is performed in the postoperative period. Once infected POPF occurs, clinicians should not hesitate to perform EUS-TD even within 15 days of the initial operation.. |
| 12. |
Yosuke Minoda, Eikichi Ihara, Keishi Komori, Haruei Ogino, Yoshihiro Otsuka, Takatoshi Chinen, Yasuo Tsuda, Koji Ando, Hidetaka Yamamoto, Yoshihiro Ogawa, Efficacy of endoscopic ultrasound with artificial intelligence for the diagnosis of gastrointestinal stromal tumors., Journal of gastroenterology, 10.1007/s00535-020-01725-4, Vol.55, No.12, pp.1119-1126, 2020.09, BACKGROUND: Although endoscopic ultrasound (EUS) is reported to be suitable for determining the layer from which subepithelial lesions (SELs) originate, it is difficult to distinguish gastrointestinal stromal tumor (GIST) from non-GIST using only EUS images. If artificial intelligence (AI) can be used for the diagnosis of SELs, it should provide several benefits, including objectivity, simplicity, and quickness. In this pilot study, we propose an AI diagnostic system for SELs and evaluate its efficacy. METHODS: Thirty sets each of EUS images with SELs ≥ 20 mm or |
| 13. |
Mitsuru Esaki, Kazuhiro Haraguchi, Kazuya Akahoshi, Naru Tomoeda, Akira Aso, Soichi Itaba, Haruei Ogino, Yusuke Kitagawa, Hiroyuki Fujii, Kazuhiko Nakamura, Masaru Kubokawa, Naohiko Harada, Yosuke Minoda, Sho Suzuki, Eikichi Ihara, Yoshihiro Ogawa, Endoscopic mucosal resection vs endoscopic submucosal dissection for superficial non-ampullary duodenal tumors., World journal of gastrointestinal oncology, 10.4251/wjgo.v12.i8.918, Vol.12, No.8, pp.918-930, 2020.08, BACKGROUND: The selection of endoscopic treatments for superficial non-ampullary duodenal epithelial tumors (SNADETs) is controversial. AIM: To compare the efficacy and safety of endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) for SNADETs. METHODS: We retrospectively analyzed the data of patients with SNADETs from a database of endoscopic treatment for SNADETs, which included eight hospitals in Fukuoka, Japan, between April 2001 and October 2017. A total of 142 patients with SNADETs treated with EMR or ESD were analyzed. Propensity score matching was performed to adjust for the differences in the patient characteristics between the two groups. We analyzed the treatment outcomes, including the rates of en bloc/complete resection, procedure time, adverse event rate, hospital stay, and local or metastatic recurrence. RESULTS: Twenty-eight pairs of patients were created. The characteristics of patients between the two groups were similar after matching. The EMR group had a significantly shorter procedure time and hospital stay than those of the ESD group [median procedure time (interquartile range): 6 (3-10.75) min vs 87.5 (68.5-136.5) min, P |
| 14. |
Yuichiro Nishihara, Haruei Ogino, Masaru Tanaka, Eikichi Ihara, Takatoshi Chinen, Kei Nishioka, Hiroko Ikeda, Yasuyo Hayashi, Hiroaki Okuno, Keita Fukaura, Jiro Nakayama, Hirotada Akiho, Yoshihiro Ogawa, TRANSCRIPTOME ANALYSIS REVEALS THAT MICROBIOTA IN THE INTESTINAL MUCOSAL IS RELATED WITH THE SEVERITY AND CLINICAL COURSE OF ULCERATIVE COLITIS, GASTROENTEROLOGY, Vol.158, No.6, p.S1037, 2020.05, 0. |
| 15. |
Yoshitaka Hata, Shohei Hamada, Masafumi Wada, Hiroko Ikeda, Keishi Komori, Haruei Ogino, Eikichi Ihara, Hirotada Akiho, Yoshihiro Ogawa, USEFULNESS OF BARIUM ESOPHAGRAM WITH NEWLY DEVELOPED WAVE APPEARANCE IN SCREENING TOOL FOR ESOPHAGEAL MOTILITY DISORDERS, GASTROENTEROLOGY, Vol.158, No.6, p.S1084, 2020.05, 0. |
| 16. |
Koki Oyama, Kenoki Ohuchida, Koji Shindo, Taiki Moriyama, Yoshitaka Hata, Masafumi Wada, Eikichi Ihara, Shuntaro Nagai, Takao Ohtsuka, Masafumi Nakamura, Thoracoscopic surgery combined with endoscopic creation of a submucosal tunnel for a large complicated esophageal leiomyoma., Surgical case reports, 10.1186/s40792-020-00854-5, Vol.6, No.1, p.92, 2020.05, BACKGROUND: The standard surgical method for symptomatic submucosal tumors (SMTs) or tumors with unclear biological behavior is enucleation. Minimally invasive approaches are usually considered appropriate for surgical enucleation; thus, thoracoscopic and laparoscopic enucleation is performed widely and safely. However, it is sometimes difficult to enucleate large and complicated esophageal tumors using thoracoscopic surgery, and even if rare, there is the risk of requiring thoracotomy or esophagectomy. In the present case, we enucleated a large and complicated leiomyoma safely using a new combined method with endoscopic and thoracoscopic procedures. CASE PRESENTATION: A 42-year-old woman presented to our hospital for a detailed examination of an abnormal finding in her health check-up chest X-ray images. She complained of upper abdominal pain after eating, and computed tomography revealed an esophageal tumor measuring 60 mm in length surrounding her lower thoracic esophagus. Esophagogastroduodenoscopy revealed a huge complicated SMT at the esophagogastric junction. Cytological examination with endoscopic ultrasound-guided fine-needle aspiration showed that the tumor was a leiomyoma. To enucleate this large and complicated esophageal SMT safely and without damaging the esophageal mucosa, we performed endoscopic and thoracoscopic procedures. We created a submucosal tunnel, endoscopically, and then performed thoracoscopic surgery to enucleate the tumor completely from the esophageal muscularis. Using these combined procedures, we were able to easily mobilize even a complicated tumor of this size from the mucosa and completed the surgery thoracoscopically without difficulty. As a result, the tumor was dissected safely with a minimal defect in the muscularis and without damaging the mucosa. Finally, we closed the defect in the esophageal muscularis with continuous sutures, thoracoscopically, and closed the entry of the submucosal tunnel using clips, endoscopically. CONCLUSIONS: Using these combined procedures, we safely enucleated a huge complicated esophageal SMT. The increased mobility of the tumor after creating the submucosal tunnel contributed to the minimal defect in the muscular layer and prevented injury to the esophageal mucosa, possibly leading to fewer postoperative complications such as esophageal stenosis and local infection.. |
| 17. |
Daisuke Yoshimura, Rie Yoshimura, Eikichi Ihara, Yoshihiro Ogawa, GASTRIC CANCER DETECTION RATES IN ACCORDANCE WITH THE INFECTION STATUS OF HELICOBACTER PYLORI UPON KYOTO CLASSIFICATION OF GASTRITIS BY SCREENING TRANSNASAL ENDOSCOPY, GASTROINTESTINAL ENDOSCOPY, 10.1016/j.gie.2019.03.823, Vol.89, No.6, p.AB500, 2019.06. |
| 18. |
Eikichi Ihara, Kazumasa Muta, Xiaopeng Bai, Shohei Hamada, Hiroko Ikeda, Keishi Komori, Haruei Ogino, Takatoshi Chinen, Yoshihiro Ogawa, ELEVATION OF BASAL EGJ PRESSURE IS ASSOCIATED WITH LOW-EFFICACY OF ACOTIAMIDE FOR THE PATIENTS WITH EGJ OUTFLOW OBSTRUCTION, GASTROENTEROLOGY, Vol.156, No.6, p.S1013, 2019.05, 0. |
| 19. |
Kei Nishioka, Keita Fukaura, Hiroaki Okuno, Yuichiro Nishihara, Haruei Ogino, Takatoshi Chinen, Eikichi Ihara, Yoshihiro Ogawa, EXPRESSION PROFILES OF HELPER T-CELL-RELATED GENES IN THE INTESTINAL MUCOSA MAY PREDICT THE EFFECT OF ANTI-TUMOR NECROSIS FACTOR-ALPHA ANTIBODY AGENTS IN ULCERATIVE COLITIS PATIENTS, GASTROENTEROLOGY, Vol.156, No.6, p.S653, 2019.05, 0. |
| 20. |
Hiroko Ikeda, Eikichi Ihara, Shohei Hamada, Kazumasa Muta, Keita Fukaura, Yoshihiro Otsuka, Yoshitaka Hata, Koji Mukai, Keishi Komori, Haruei Ogino, Takatoshi Chinen, Yoshihiro Ogawa, IMPAIRED ESOPHAGOGASTRIC JUNCTION RECESSIVE RELAXATION PLAYS A CENTRAL ROLE IN ESOPHAGEAL MOTILITY DISORDERS ASSOCIATED WITH SYSTEMIC SCLERODERMA, GASTROENTEROLOGY, Vol.156, No.6, p.S995, 2019.05, 0. |
| 21. |
Yoshihiro Otsuka, Eikichi ihara, Xiaopeng Bai, Takatoshi Chinen, Haruei Ogino, Hirotada Akiho, Yoshihiro Ogawa, INTERSTITIAL CELLS OF CAJAL PLAY A CRUCIAL ROLE IN THE NEUROTRANSMISSION OF NICOTINIC ACETYLCHOLINE RECEPTOR IN PORCINE LOWER ESOPHAGEAL SPHINCTER, GASTROENTEROLOGY, Vol.156, No.6, p.S539, 2019.05, 0. |
| 22. |
Shohei Hamada, Eikichi Ihara, Kazumasa Muta, Hiroko Ikeda, Kouzi Mukai, Yoshihiro Otsuka, Yoshitaka Hata, Haruei Ogino, Takatoshi Chinen, Yoshihiro Ogawa, SIGNIFICANT DIFFERENCE IN THE PROPORTION OF UNDERLYING DISEASES BETWEEN CONVENTIONAL PROTON PUMP INHIBITORS AND VONOPRAZAN REFRACTORY GASTROESOPHAGEAL REFLUX DISEASE., GASTROENTEROLOGY, Vol.156, No.6, pp.S305-S306, 2019.05, 0. |
| 23. |
Daisuke Yoshimura, Toshiaki Ochiai, Eikichi Ihara, Yoshihiro Ogawa, TOXIN A AND B COMBINED WITH GLUTAMATE DEHYDROGENASE IMMUNOASSAYS CAN SAVE TOXIGENIC CULTURE FOR THE DIAGNOSIS OF CLOSTRIDIUM DIFFICILE INFECTION, GASTROENTEROLOGY, Vol.156, No.6, pp.S900-S901, 2019.05, 0. |
| 24. |
自律神経と消化管-脳腸相関における自律神経の役割を考える 本邦における自己免疫性消化管運動障害の臨床的特徴の解析 自己免疫性自律神経節障害との関連について考える. |
| 25. |
自己免疫性消化管運動障害の臨床的特徴. |
| 26. |
Hirotada Akiho, Mitsuru Esaki, Haruei Ogino, Taizo Hosokawa, Takahiro Mizutani, Eikichi Ihara, CLINICAL OUTCOME OF ENDOSCOPIC SUBMUCOSAL DISSECTION FOR EARLY GASTRIC CANCER IN A POST-OPERATIVE STOMACH, GASTROINTESTINAL ENDOSCOPY, Vol.87, No.6, p.AB244, 2018.06. |
| 27. |
Yasuyo Hayashi, Mitsuru Esaki, Taizo Hosokawa, Yoshimasa Tanaka, Haruei Ogino, Takahiro Mizutani, Eikichi Ihara, Hirotada Akiho, COMPARISON BETWEEN CLUTCH CUTTER AND OTHER DEVICES IN THE TECHNICAL OUTCOMES IN ENDOSCOPIC SUBMUCOSAL DISSECTION FOR EARLY GASTRIC CANCER, GASTROINTESTINAL ENDOSCOPY, Vol.87, No.6, p.AB266, 2018.06. |
| 28. |
Takashi Osoegawa, Yorinobu Sumida, Naohiko Harada, Hirotaka Turu, Tomonori Mishima, Masafumi Wada, Yoichiro Iboshi, Eikichi Ihara, Makoto Nakamuta, EFFECTIVENESS OF PREOPERATIVE TOTAL COLONOSCOPY AND COMPUTED TOMOGRAPHIC COLONOGRAPHY AFTER PLACEMENT OF A SELF-EXPANDABLE METALLIC STENT AS A BRIDGE TO SURGERY, GASTROINTESTINAL ENDOSCOPY, Vol.87, No.6, pp.AB56-AB57, 2018.06. |
| 29. |
Daisuke Yoshimura, Toshiaki Ochiai, Shin-ichiro Fukuda, Kojiro Niho, Yusuke Kitagawa, Eikichi Ihara, Yoshihiro Ogawa, PERIOPERATIVE HEPARIN BRIDGING FOR COLORECTAL EMR OR ESD FOR PATIENTS RECEIVING ANTICOAGULATION RESULTED IN A VERY HIGH INCIDENCE OF BLEEDING COMPLICATION, GASTROINTESTINAL ENDOSCOPY, Vol.87, No.6, p.AB508, 2018.06. |
| 30. |
Kazumasa Muta, Eikichi Ihara, Keita Fukaura, Xiaopeng Bai, Yoshitaka Hata, Haruei Ogino, Toshiaki Ochiai, Kazuhiko Nakamura, Yoshihiro Ogawa, BOTH INCOMPLETE LES RELAXATION AND PREMATURE CONTRACTION OF ESOPHAGEAL BODY ARE CHARACTERISTICS OF DRY SWALLOW, GASTROENTEROLOGY, Vol.154, No.6, p.S745, 2018.05, 0. |
| 31. |
Daisuke Yoshimura, Rie Yoshimura, Seiya Kato, Toshiaki Ochiai, Shin-ichiro Fukuda, Kojiro Niho, Yusuke Kitagawa, Eikichi Ihara, Yoshihiro Ogawa, GASTRIC CANCER WITHOUT HELICOBACTER PYLORI INFECTION OTHER THAN GASTRIC CARDIA CANCER IS LESS INVASIVE, GASTROENTEROLOGY, Vol.154, No.6, p.S936, 2018.05, 0. |
| 32. |
Kazumasa Muta, Eikichi Ihara, Shohei Hamada, Keita Fukaura, Xiaopeng Bai, Yoshihiro Otsuka, Yoshitaka Hata, Koji Mukai, Keishi Komori, Tsutomu Iwasa, Hirotada Akiho, Kazuhiko Nakamura, Yoshihiro Ogawa, MUCOSALLY EXPRESSED PROTEASE-ACTIVATED RECEPTOR 2 AND TRANSIENT RECEPTOR POTENTIAL VANILLOID 1 ARE ASSOCIATED WITH FUNCTIONAL HEARTBURN, GASTROENTEROLOGY, Vol.154, No.6, p.S478, 2018.05, 0. |
| 33. |
Xiaopeng Bai, Eikichi Ihara, Yoshihiro Otsuka, Haruei Ogino, Hirotada Akiho, Kazuhiko Nakamura, Yoshihiro Ogawa, NICOTINE CAUSED THE DUAL REGULATION OF TONE IN THE PORCINE LOWER ESOPHAGEAL SPHINCTER THROUGH EXCITATORY AND INHIBITORY ENTERIC INNERVATION, GASTROENTEROLOGY, Vol.154, No.6, pp.S963-S964, 2018.05, 0. |
| 34. |
Shohei Hamada, Eikichi Ihara, Kazumasa Muta, Keita Fukaura, Haruei Ogino, Xiaopeng Bai, Koji Mukai, Yoshihiro Otsuka, Keishi Komori, Yoshitaka Hata, Akira Aso, Tsutomu Iwasa, Toshiaki Ochiai, Hirotada Akiho, Kazuhiko Nakamura, Yoshihiro Ogawa, THE ESOPHAGEAL INTRALUMINAL BASELINE IMPEDANCE DIFFERENTIATES REFLUX HYPERSENSITIVITY FROM NERD, GASTROENTEROLOGY, Vol.154, No.6, p.S479, 2018.05, 0. |
| 35. |
Mitsuru Esaki, Hirotada Akiho, Haruei Ogino, Taizo Hosokawa, Yusuke Niina, Eikichi Ihara, Kazuhiko Nakamura, Safety Advantage of the New Device (Splash-M Knifea (R)) for Endoscopic Submucosal Dissection of Early Gastric Neoplasms, GASTROINTESTINAL ENDOSCOPY, 10.1016/j.gie.2017.03.1167, Vol.85, No.5, pp.AB504-AB505, 2017.05. |
| 36. |
Daisuke Yoshimura, Rie Yoshimura, Takahiro Mizutani, Toshiaki Ochiai, Seiya Kato, Kojiro Niho, Risa Iwao, Yusuke Kitagawa, Muneki Akutagawa, Hiroko Ikeda, Koji Mukai, Akihiko Nakashima, Eikichi Ihara, Kazuhiko Nakamura, Yoshihiro Ogawa, CLINICAL AND PATHOLOGICAL CHARACTERISTICS OF GASTRIC CANCER WITHOUT HELICOBACTER PYLORI INFECTION AND ITS BACKGROUND GASTRIC MUCOSA, GASTROENTEROLOGY, 10.1016/S0016-5085(17)31170-8, Vol.152, No.5, p.S260, 2017.04, 0. |
| 37. |
Yoshitaka Hata, Eikichi Ihara, Keita Fukaura, Kazumasa Muta, Xiaopeng Bai, Tsutomu Iwasa, Akira Aso, Hirotada Akiho, Kazuhiko Nakamura, Yoshihiro Ogawa, ESOPHAGOGASTRIC JUNCTION OUTFLOW OBSTRUCTION IS DISCRIMINATED FROM ACHALASIA BY ESOPHAGEALLY EXPRESSED CYOTOKINE PROFILES USING LINEAR DISCRIMINANT ANALYSIS, GASTROENTEROLOGY, 10.1016/S0016-5085(17)31351-3, Vol.152, No.5, pp.S321-S322, 2017.04, 0. |
| 38. |
Kazumasa Muta, Eikichi Ihara, Keita Fukaura, Xiaopeng Bai, Shouhei Hamada, Toshiaki Ochiai, Tsutomu Iwasa, Akira Aso, Kazuhiko Nakamura, LOWER ESOPHAGEAL SPHINCTER (LES) RECEPTIVE RELAXATION IS INDISPENSABLE FOR SUCCESSFUL LES RELAXATION IN WET SWALLOWING, GASTROENTEROLOGY, 10.1016/S0016-5085(17)31346-X, Vol.152, No.5, p.S320, 2017.04, 0. |
| 39. |
Yoshihiro Otsuka, Xiaopeng Bai, Eikichi Ihara, Kazuhiko Nakamura, Yoshihiro Ogawa, RHO KINASE-ASSOCIATED MYOGENIC CONTRACTION COMPENSATES FOR REDUCED FORCE INDUCED BY RELEASE AFTER STRETCHING IN THE PORCINE LOWER ESOPHAGEAL SPHINCTER, GASTROENTEROLOGY, 10.1016/S0016-5085(17)32423-X, Vol.152, No.5, pp.S691-S692, 2017.04, 0. |
| 40. |
Yoichiro Iboshi, Kazuhiko Nakamura, Keita Fukaura, Tsutomu Iwasa, Haruei Ogino, Yorinobu Sumida, Eikichi Ihara, Hirotada Akiho, Naohiko Harada, Makoto Nakamuta, Increased IL-17A/IL-17F expression ratio represents the key mucosal T helper/regulatory cell-related gene signature paralleling disease activity in ulcerative colitis (vol 52, pg 315, 2017), JOURNAL OF GASTROENTEROLOGY, 10.1007/s00535-016-1231-z, Vol.52, No.3, p.396, 2017.03. |
| 41. |
Eikichi Ihara, Kazumasa Muta, Keita Fukaura, Kazuhiko Nakamura, Diagnosis and Treatment Strategy of Achalasia Subtypes and Esophagogastric Junction Outflow Obstruction Based on High-Resolution Manometry, Digestion, 10.1159/000452354, 2017.01, Background: Based on Chicago Classification version 3.0, the disorders of esophagogastric junction outflow obstruction (EGJOO) include achalasia (types I, II and III) and EGJOO. Although no curative treatments are currently available for the treatment of the disorders of EGJOO, medical treatments, endoscopic pneumatic dilation (PD), laparoscopic Heller myotomy (LHM), and per-oral endoscopic myotomy (POEM) are usually the sought-after modes of treatment. Since the etiology and pathogenesis might vary depending on the types of EGJOO disorders, treatment strategies should be considered based on those subtypes. Summary: Based on the accumulated evidences, the treatment strategies of our institution are as follows: effects of medical treatments on achalasia are limited. Either PD or LHM/POEM can be considered a first-line in achalasia type I, according to the patient's wish. PD and POEM can be considered first-line in achalasia types II and III, respectively. Conversely, In EGJOO, medical treatments including drugs like acotiamide and/or diltiazem can be tested as a first-line, and PD and POEM will be considered second and third-line treatments, respectively. Key Messages: The classification of subtypes based on high-resolution manometry will help us consider which treatment option can be selected as a first-line treatment depending upon the subtypes of disorders of EGJOO. Acotiamide has the potential to cure patients with EGJOO.. |
| 42. |
Yoichiro Iboshi, Kazuhiko Nakamura, Keita Fukaura, Tsutomu Iwasa, Haruei Ogino, Yorinobu Sumida, Eikichi Ihara, Hirotada Akiho, Naohiko Harada, Makoto Nakamuta, Mucosal IL-13 Expression Correlates with Disease Activity Portion That Is Unexplained by Th17-Related Gene Signature in a Subset of Ulcerative Colitis Patients, AMERICAN JOURNAL OF GASTROENTEROLOGY, 10.14309/00000434-201610001-00685, Vol.111, pp.S311-S312, 2016.10. |
| 43. |
Eikichi Ihara, Kazumasa Muta, Keita Fukaura, Yoshimasa Tanaka, Xiaopeng Bai, Akira Aso, tsutomu iwasa, Kazuhiko Nakamura, New Approach to Diagnosis and Treatment of Esophageal Motility Disorders by High-Resolution manometry, Fukuoka Acta Medica, 2016.07, Esophageal motility disorders (EMD) is characterized by impaired coordinated esophageal motility function with symptoms including dysphasia, heartburn or noncardiac chest pain. Since EMDs is functional disorders, it is usually difficult to make a diagnosis by conventional examinations including endoscopy and esophagography. Recently developed high-resolution manometry allows us to evaluate esophageal motility function precisely and to make a differential diagnosis of EMDs, together with Chicago Classification (CC) version 3.0 (CC ver3.0). In this article, we reviewed diagnosis of EMDs based on CC ver3.0 and current treatment strategy for EMDs.. |
| 44. |
Hirotada Akiho, Haruei Ogino, Mitsuru Esaki, Eikichi Ihara, Kazuhiko Nakamura, Masahiro Yamamoto, Daikenchuto (DKT), a Japanese Traditional Herbal Medicine Ameliorated Gastrointestinal Hypermotility by Downregulated the Interleukin-17A in a Murine Functional Gastrointestinal Disorder Model, GASTROENTEROLOGY, 10.1016/S0016-5085(16)33059-1, Vol.150, No.4, p.S904, 2016.04. |
| 45. |
Xiaopeng Bai, Eikichi Ihara, Yoshimasa Tanaka, Katsuya Hirano, Mayumi Hirano, Kazuhiko Nakamura, Involvement of Different Subtypes of Receptor in Prostaglandin E2-Induced Motile Function in Lower Esophageal Sphincter and Esophageal Body Smooth Muscle, GASTROENTEROLOGY, Vol.150, No.4, p.S458, 2016.04, 0. |
| 46. |
Kazumasa Muta, Eikichi Ihara, Keita Fukaura, Xiaopeng Bai, Yoshimasa Tanaka, Osamu Tsuchida, Toshiaki Ochiai, Tsutomu Iwasa, Akira Aso, Kazuhiko Nakamura, Mechanisms of Acotiamide-Sensitive Impaired Lower Esophageal Sphincter Accommodation in Patients With Esophagogastric Junction Outflow Obstruction, GASTROENTEROLOGY, 10.1016/S0016-5085(16)31612-2, Vol.150, No.4, p.S468, 2016.04. |
| 47. |
Eikichi Ihara, Keita Fukaura, Kazumasa Muta, Yoshimasa Tanaka, Xiaopeng Bai, Tsutomu Iwasa, Akira Aso, Hirotada Akiho, Kazuhiko Nakamura, Protease-Activated Receptor Expression in the Esophagus Is Associated With Esophageal Mucosal Integrity and Esophageal Motility Function, GASTROENTEROLOGY, 10.1016/S0016-5085(16)30272-4, Vol.150, No.4, pp.S43-S44, 2016.04, 0. |
| 48. |
Xiaopeng Bai, Eikichi Ihara, Yoshimasa Tanaka, Katsuya Hirano, Mayumi Hirano, Hirotada Akiho, Kazuhiko Nakamura, Trypsin Induced a Transient Contraction via a PAR2/TRPV1/Neurokinin Receptors Pathway in Circular Smooth Muscle of Porcine Esophageal Body, GASTROENTEROLOGY, Vol.150, No.4, p.S458, 2016.04, 0. |
| 49. |
Yoichiro Iboshi, Kazuhiko Nakamura, Keita Fukaura, Tsutomu Iwasa, Haruei Ogino, Yorinobu Sumida, Eikichi Ihara, Hirotada Akiho, Naohiko Harada, Makoto Nakamuta, Key Mucosal Helper T Cell-Related Gene Signature Paralleling Disease Activity in Ulcerative Colitis Is Underlain by Different Interactions Between IL-17A and IL-17F With Other Helper T Cell-Related Genes, AMERICAN JOURNAL OF GASTROENTEROLOGY, 10.14309/00000434-201510001-01890, Vol.110, p.S803, 2015.10. |
| 50. |
Kazumasa Muta, Eikichi Ihara, Keita Fukaura, Xiaopeng Bai, Yoshimasa Tanaka, Kazuhiko Nakamura, Toshiaki Ochiai, Osamu Tsuchida, Hirotada Akiho, Ryoichi Takayanagi, Acotiamide Has the Potential to Become a Promising Treatment for Patients With Esophagogastric Junction Outflow Obstruction, GASTROENTEROLOGY, Vol.148, No.4, p.S803, 2015.04. |
| 51. |
Yoshimasa Tanaka, Eikichi Ihara, Kazumasa Muta, Keita Fukaura, Koji Mukai, Xiaopeng Bai, Kazuhiko Nakamura, Hirotada Akiho, Ryoichi Takayanagi, Clinical Characteristics Associated With Function of Esophageal Motility: A Retrospective Analysis of 97 Patients, GASTROENTEROLOGY, Vol.148, No.4, p.S818, 2015.04. |
| 52. |
Xiaopeng Bai, Eikichi Ihara, Yoshimasa Tanaka, Katsuya Hirano, Mayumi Hirano, Hirotada Akiho, Kazuhiko Nakamura, Ryoichi Takayanagi, Endogenous H2S Contributes to Myogenic Tone Generation in Lower Esophageal Sphincter: Possible Involvement of Na+/CA(2+) Exchanger, GASTROENTEROLOGY, Vol.148, No.4, p.S78, 2015.04. |
| 53. |
Keita Fukaura, Eikichi Ihara, Kazumasa Muta, Yoshimasa Tanaka, Xiaopeng Bai, Kazuhiko Nakamura, Ryoichi Takayanagi, The Cytokine Expression Patterns of Esophageal Mucosa Are Associated With Esophageal Motility Function in Human, GASTROENTEROLOGY, Vol.148, No.4, p.S882, 2015.04. |
| 54. |
Kazumasa Muta, Eikichi Ihara, Xiaopeng Bai, Yoshimasa Tanaka, Kazuhiko Nakamura, Hirotada Akiho, Ryoichi Takayanagi, Acotiamide, a Novel Prokinetic Drug, Reduces Both Esophageal Body Contractility and the Tone of the Lower Esophageal Sphincter, GASTROENTEROLOGY, Vol.146, No.5, p.S683, 2014.05. |
| 55. |
Xiaopeng Bai, Yoshimasa Tanaka, Eikichi Ihara, Katsuya Hirano, Mayumi Hirano, Kazuhiko Nakamura, Hirotada Akiho, Ryoichi Takayanagi, Different Contractile and Relaxant Effects of Trypsin in Phasic Smooth Muscles of the Esophageal Body and the Tonic Lower Esophageal Sphincter, GASTROENTEROLOGY, Vol.146, No.5, p.S862, 2014.05. |
| 56. |
Hirotada Akiho, Katsuya Ohbuchi, Kazuaki Tsuchiya, Eikichi Ihara, Kazuhiko Nakamura, Masahiro Yamamoto, IL-17A and IL-1 beta Exert I kappa B zeta-Mediated, but Oppositely-Directed, Effects on Contractility and RGS4 Translocation in Small Intestinal Smooth Muscle Cells, Whose Directions Are Determined by the Balance Between P38mapk and JNK Activities, GASTROENTEROLOGY, Vol.146, No.5, p.S526, 2014.05. |
| 57. |
Hirotada Akiho, Katsuya Ohbuchi, Eikichi Ihara, Kazuhiko Nakamura, Masahiro Yamamoto, IL-17 Enhances Carbachol-Induced CA(2+) Influx and Contraction of Human Colonic Smooth Muscle Cells, GASTROENTEROLOGY, Vol.144, No.5, p.S551, 2013.05. |
| 58. |
Yoshimasa Tanaka, Eikichi Ihara, Katsuya Hirano, Mayumi Hirano, Kazuhiko Nakamura, Hirotada Akiho, Ryoichi Takayanagi, Trypsin Induced BiPhasic Contraction and Relaxation in the Porcine Lower Esophageal Sphincter, GASTROENTEROLOGY, Vol.144, No.5, p.S857, 2013.05, 0. |
| 59. |
Matsui N, Akahoshi K, Nakamura K, Ihara E, Kita H, Endoscopic submucosal dissection for removal of superficial gastrointestinal neoplasms: A technical review., World J Gastrointest Endosc, 2012.09, Endoscopic submucosal dissection (ESD) is now the most common endoscopic treatment in Japan for intramucosal gastrointestinal neoplasms (non-metastatic). ESD is an invasive endoscopic surgical procedure, requiring extensive knowledge, skill, and specialized equipment. ESD starts with evaluation of the lesion, as accurate assessment of the depth and margin of the lesion is essential. The devices and strategies used in ESD vary, depending on the nature of the lesion. Prior to the procedure, the operator must be knowledgeable about the treatment strategy(ies), the device(s) to use, the electrocautery machine settings, the substances to inject, and other aspects. In addition, the operator must be able to manage complications, should they arise, including immediate recognition of the complication(s) and its treatment. Finally, in case the ESD treatment is not successful, the operator should be prepared to apply alternative treatments. Thus, adequate knowledge and training are essential to successfully perform ESD.. |
| 60. |
Yohei Tokita, Kazuko Satoh, Mitsue Nishiyama, Hirotada Akiho, Kazuhiko Nakamura, Eikichi Ihara, Ryoichi Takayanagi, Masahiro Yamamoto, IL-17 Induces Hypercontractility in Intestinal Smooth Muscle Strips and Cells via Nf kappa B Signaling, GASTROENTEROLOGY, Vol.142, No.5, p.S891, 2012.05. |
| 61. |
Mitsue Nishiyama, Yohei Tokita, Kazuko Satoh, Hirotada Akiho, Kazuhiko Nakamura, Eikichi Ihara, Ryoichi Takayanagi, Masahiro Yamamoto, IL-17 Suppresses RGS4 Translocation in Primary Cultured Intestinal Smooth Muscle Cells via I kappa B zeta Signaling: an Indication of a Mechanism of IL-17-Induced Gut Hypermotility, GASTROENTEROLOGY, Vol.142, No.5, p.S4, 2012.05. |
| 62. |
Kazuko Satoh, Yohei Tokita, Mitsue Nishiyama, Hirotada Akiho, Kazuhiko Nakamura, Eikichi Ihara, Ryoichi Takayanagi, Masahiro Yamamoto, IL-17 is Critically Involved in the Gut Hypermotility Following Resolution of T-Cell Mediated Inflammation, GASTROENTEROLOGY, Vol.142, No.5, p.S4, 2012.05. |
| 63. |
Eikichi Ihara, Kuniomi Honda, Yoshitaka Hata, Yorinobu Sumida, Hirotada Akiho, Kazuhiko Nakamura, Ryoichi Takayanagi, Preoperative Tissue Sampling of Suspected Gastric Gastrointestinal Stromal Tumors by Mucosal Incision Assisted Biopsy, GASTROENTEROLOGY, Vol.142, No.5, p.S761, 2012.05. |
| 64. |
Ihara E, Akiho H, Nakamura K, Turner SR, MacDonald JA, MAPK signaling pathways represent a possible ideal target for generation of novel therapeutics for patients with gastrointestinal motility disorders. , World J Gastrointest Pathophysiol 2:19-25, 2011.07. |
| 65. |
Akiho H, Ihara E, Motomura Y, Nakamura K. , Cytokine-induced alteration of gastrointestinal motility in gastrointestinal disorders. , World J Gastrointest Pathophysiol. , 2011.05. |
| 66. |
Akiho H, Ihara E, Nakamura. K, Low-grade inflammation plays a pivotal role in gastrointestinal dysfunction in irritable bowel syndrome. , World J Gastrointest Pathophysiol 1:97-105, 2010.07. |
| 67. |
Simon A. Hirota, Jeff Ng, Eikichi Ihara, Yan Li, Daniel Muruve, Glen D. Armstrong, Sean P. Colgan, Daniel Chung, Paul L. Beck, Justin A. MacDonald, Hypoxia Inducible Factor (HIF-1 alpha) Plays a Critical Innate Protective Role in Clostridium difficile (Cdif) Toxin-Induced Intestinal Injury and Inflammation, GASTROENTEROLOGY, Vol.136, No.5, pp.A81-A82, 2009.05. |
| 68. |
Eikichi Ihara, Simon A. Hirota, Paul L. Beck, Justin A. MacDonald, Upregulation of HIF-1 alpha is associated with augmented rho-kinase-mediated contraction of ileal smooth muscle following exposure to clostridium difficile toxins in a mouse ileal loop model, GASTROENTEROLOGY, Vol.134, No.4, p.A258, 2008.04. |
| 69. |
Ihara E and MacDonald JA, The regulation of smooth muscle contractility by zipper-interacting protein kinase. , Can J Physiol Pharmacol 85: 79-87., 2007.07. |
