Kyushu University [Gaku Tsuji (Associate Professor) Kyushu University Hospital, Reserch and Clinical Center for Yusho and Dioxin]

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Researcher information

Gaku Tsuji
Associate Professor
Reserch and Clinical Center for Yusho and Dioxin
Kyushu University Hospital
Last modified date：2020.06.08

Graduate School

Department of Medicine
Graduate School of Medical Sciences

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Research

Research Interests

The role of autophagy in the skin
keyword : autophagy
2018.01～2020.03.
The roles of aryl hydrocarbon receptor of the skin
keyword : Aryl Hydrocarbon Receptor
2007.04～2017.03.

Academic Activities

Reports

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1.	Tsuji G, Ito T, Chiba T, Mitoma C, Nakahara T, Uchi H, Furue M., The role of the OVOL1-OVOL2 axis in normal and diseased human skin., J Dermatol Sci., 2018.06.

Papers

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1.	Hashimoto-Hachiya, Akiko; Tsuji, Gaku; Furue, Masutaka, Antioxidants cinnamaldehyde and Galactomyces fermentation filtrate downregulate senescence marker CDKN2A/p16INK4A via NRF2 activation in keratinocytes, JOURNAL OF DERMATOLOGICAL SCIENCE, 10.1016/j.jdermsci.2019.09.002, 96, 1, 53-56, 2019.10.
2.	Tsuji G, Hashimoto-Hachiya A, Yen VH, Takemura M, Yumine A, Furue K, Furue M, Nakahara T., Metformin inhibits IL-1β secretion via impairment of NLRP3 inflammasome in keratinocytes: implications for preventing the development of psoriasis., Cell Death Discov. , doi: 10.1038/s41420-020-0245-8. , 2020.05.
3.	Tsuji G, Hashimoto-Hachiya A, Yen VH, Miake S, Takemura M, Mitamura Y, Ito T, Murata M, Furue M, Nakahara T., Aryl Hydrocarbon Receptor Activation Downregulates IL-33 Expression in Keratinocytes via Ovo-Like 1., J Clin Med. , doi: 10.3390/jcm9030891, 2020.05.
4.	Takemura M, Nakahara T, Hashimoto-Hachiya A, Furue M, Tsuji G., Glyteer, Soybean Tar, Impairs IL-4/Stat6 Signaling in Murine Bone Marrow-Derived Dendritic Cells: The Basis of Its Therapeutic Effect on Atopic Dermatitis., Int J Mol Sci. , 2018.04.
5.	Tsuji, Gaku; Hashimoto-Hachiya, Akiko; Takemura, Masaki; Kanemaru, Takaaki; Ichihashi, Masamitsu; Furue, Masutaka, Palladium and Platinum Nanoparticles Activate AHR and NRF2 in Human Keratinocytes-Implications in Vitiligo Therapy, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 10.1016/j.jid.2017.02.981, 137, 7, 1582-1586, 2017.07.
6.	Tsuji, Gaku; Hashimoto-Hachiya, Akiko; Kiyomatsu-Oda, Mari; Takemura, Masaki; Ohno, Fumitaka; Ito, Takamichi; Morino-Koga, Saori; Mitoma, Chikage; Nakahara, Takeshi; Uchi, Hiroshi; Furue, Masutaka, Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis, CELL DEATH & DISEASE, 10.1038/cddis.2017.322, 8, 2017.07.
7.	Takamichi Ito, Gaku Tsuji, Fumitaka Ohno, Hiroshi Uchi, Takeshi Nakahara, Akiko Hachiya, Yuichi Yoshida, Osamu Yamamoto, Oda, Yoshinao, Masutaka Furue, Activation of the OVOL1-OVOL2 Axis in the Hair Bulb and in Pilomatricoma., Am J Pathol, 186, 4, 1036-1043, 2016.04.
8.	Gaku Tsuji, Histone deacetylase 6 inhibition impairs effector CD8 T-cell functions during skin inflammation., J Allergy Clin Immunol. , 135(5):1228-1239, 2015.05.
9.	Tsuji G, Takahara M, Uchi H, Matsuda T, Chiba T, Takeuchi S, Yasukawa F, Moroi Y, Furue M., Identification of Ketoconazole as an AhR-Nrf2 Activator in Cultured Human Keratinocytes: The Basis of Its Anti-Inflammatory Effect., J Invest Dermatol., 10.1038/jid., 2011.07.
10.	Tsuji G, Takahara M, Uchi H, Takeuchi S, Mitoma C, Moroi Y, Furue M., An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway., J Dermatol Sci., ６２, １, ４２－４９, 2011.04.

Presentations

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1.	Tsuji G, Hashimoto-Hachiya A, Yan X, and Furue M, Galactomyces fermentation filtrate protects human keratinocytes against oxidative stress induced-cellular senescence via induction of autophagy. , 24th World Congress of Dermatology , 2019.06.
2.	Gaku Tsuji, Akiko Hachiya, 中原剛士, 三苫千景, 古江増隆, AHR regulates FLG expression via OVOL1 in human keratinocytes: A plausible relationship between FLG and OVOL1 in atopic dermatitis, ASDR 2016, 2016.08.
3.	Gaku Tsuji, Activation of aryl hydrocarbon receptor-nuclear factor erythroid 2-related factor 2 signaling axis by epidermal growth factor receptor inhibitors: a possible mechanism for acneiform eruption. , 45th Annual ESDR Meeting , 2015.09.
4.	Gaku Tsuji, Activation of OVOL1-OVOL2 axis in hair bulb, pilomatricoma and pilomatrix carcinoma., 日本研究皮膚科学会, 2015.12.
5.	Gaku Tsuji, Activation of aryl hydrocarbon receptor-nuclear factor erythroid 2-related factor 2 axis by epidermal growth factor receptor inhibitors: a possible mechanism for acneiform eruption., ４5TH ANNUAL ESDR MEETING, 2015.09.
6.	Gaku Tsuji, Tubacin, a histone deacetylase 6 inhibitor, suppresses contact sensitivity via impairment of the immune synapse. , International Investigative Dermatology 8th, 2013.05.
7.	Gaku Tsuji, Cynaropicrin, an extract from artichoke, inhibits UVB-induced oxidative stress in cultured human keratinocytes. , Society of Investigative Dermatology 72nd Annual meeting , 2012.05.

Awards

Activation of aryl hydrocarbon receptor-nuclear factor erythroid 2-related factor 2 axis by epidermal growth factor receptor inhibitors: a possible mechanism for acneiform eruption

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