環境調和型反応を用いた医薬品合成研究
キーワード：環境調和型反応、触媒反応
2012.04～2017.03.

主要著書

主要原著論文

1.	T. Tanaka, Y. Koga, Y. Honda, A. Tsuruta, N. Matsunaga, S. Koyanagi, S. Ohdo, R. Yazaki, T. Ohshima, Ternary catalytic α-deuteration of carboxylic acids, Nature Synthesis, 10.1038/s44160-022-00139-9, 1, 10, 824-830, 2022.09, カルボン酸を用いた世界初の触媒的重水素化反応を開発.
2.	Taro Tsuji, Kayoko Hashiguchi, Mana Yoshida, Tetsu Ikeda, Yunosuke Koga, Yusaku Honda, Tsukushi Tanaka, Suyong Re, Kenji Mizuguchi, Daisuke Takahashi, Ryo Yazaki, Takashi Ohshima, α-Amino acid and peptide synthesis using catalytic cross-dehydrogenative coupling, Nature Synthesis, 10.1038/s44160-022-00037-0, 1, 4, 304-312, 2022.04, 世界で最も嵩高い非天然アミノ酸合成法を開発.
3.	Yohei Matsumoto, Jun Sawamura, Yumi Murata, Takashi Nishikata, Ryo Yazaki, Takashi Ohshima, Amino Acid Schiff Base Bearing Benzophenone Imine as a Platform for Highly Congested Unnatural α-Amino Acid Synthesis, Journal of the American Chemical Society, 10.1021/jacs.0c02707, 2020.05, [URL], α-アミノ酸は私たちの体をつくるたんぱく質の構成成分として、生命活動を維持するための重要な役割を担っています。また最近では、創薬分野において低分子と抗体の特徴を有した中分子ペプチド、中でも天然には存在しない非天然α—アミノ酸を有する中分子ペプチドが革新的な次世代型医薬品として期待されています。そのため非天然α—アミノ酸の合成法は古くより盛んに研究が行われてきました。しかし立体的に大きな非天然α—アミノ酸、特に連続して立体的に大きな部位をもつ非天然α—アミノ酸の合成はこれまで非常に困難で、その機能を調べるための一般性の高い合成法の開発が強く望まれていました。このような背景のもと、九州大学大学院薬学府修士課程2年の松本洋平大学院生（研究当時）、薬学研究院の矢崎亮助教、大嶋孝志教授らと山口大学大学院創成科学研究科応用化学分野の西形孝司教授らの研究グループは、立体的に大きな非天然α—アミノ酸を効率的に合成する手法の開発に世界に先駆けて成功しました。.
4.	Yohei Matsumoto, Jun Sawamura, Yumi Murata, Takashi Nishikata, Ryo Yazaki, Takashi Ohshima, Amino Acid Schiff Base Bearing Benzophenone Imine As a Platform for Highly Congested Unnatural α-Amino Acid Synthesis, Journal of the American Chemical Society, 10.1021/jacs.0c02707, 2020.05.
5.	Tsukushi Tanaka, Ryo Yazaki, Takashi Ohshima, Chemoselective Catalytic α-Oxidation of Carboxylic Acids: Iron/Alkali Metal Cooperative Redox Active Catalysis, Journal of the American Chemical Society, 10.1021/jacs.0c00727, 2020.03.
6.	Tsukushi Tanaka, Ryo Yazaki, Takashi Ohshima, Chemoselective Catalytic α-Oxidation of Carboxylic Acids Iron/Alkali Metal Cooperative Redox Active Catalysis, Journal of the American Chemical Society, 10.1021/jacs.0c00727, 2020.01, [URL], We developed a chemoselective catalytic activation of carboxylic acid for a 1e- radical process. α-Oxidation of a variety of carboxylic acids, which preferentially undergo undesired decarboxylation under radical conditions, proceeded efficiently under the optimized conditions. Chemoselective enolization of carboxylic acid was also achieved even in the presence of more acidic carbonyls. Extensive mechanistic studies revealed that the cooperative actions of iron species and alkali metal ions derived from 4 Å molecular sieves substantially facilitated the enolization. For the first time, catalytic enolization of unprotected carboxylic acid was achieved without external addition of stoichiometric amounts of Brønsted base. The formed redox-active heterobimetallic enediolate efficiently coupled with free radical TEMPO, providing synthetically useful α-hydroxy and keto acid derivatives..
7.	Ryo Yazaki, Takashi Ohshima, Recent strategic advances for the activation of benzylic C–H bonds for the formation of C–C bonds, Tetrahedron Letters, 10.1016/j.tetlet.2019.151225, 60, 45, 2019.11, [URL], Alkylarenes, obtained from abundant hydrocarbon feedstock sources, are an attractive starting material for the formation of complex molecular architectures. Conventional activation strategies of the relatively inert sp3-hybridized benzylic C–H bonds usually require relatively harsh conditions and are difficult to apply to the synthesis of fine chemicals. The present review describes recent strategic advances for the activation of benzylic C–H bonds for the catalytic formation of C–C bonds. In particular, two activation methods, i.e., strategies that generate benzylic radicals or benzyl anions, are discussed..
8.	Tsukushi Tanaka, Kayoko Hashiguchi, Takafumi Tanaka, Ryo Yazaki, Takashi Ohshima, Chemoselective Catalytic Dehydrogenative Cross-Coupling of 2-Acylimidazoles Mechanistic Investigations and Synthetic Scope, ACS Catalysis, 10.1021/acscatal.8b02361, 8, 9, 8430-8440, 2018.09, [URL], Chemoselective iron-catalyzed dehydrogenative cross-coupling using 2-acylimidazoles is described. The addition of a phosphine oxide ligand substantially facilitated the generation of tert-butoxy radicals from di-tert-butyl peroxide, allowing for efficient benzylic C-H bond cleavage under mild conditions. Extensive mechanistic studies revealed that the enolization of 2-acylimidazole proceeded through dual iron catalyst activation, followed by subsequent chemoselective cross-coupling with a benzyl radical over an undesired benzyl radical-derived homocoupling dimer that inevitably formed in earlier reported conditions. A variety of alkylarenes, aliphatic alkane, and functionalized 2-acylimidazoles were applicable, demonstrating the synthetic utility of the present catalysis. Contiguous all-carbon quaternary carbons were constructed through dehydrogenative cross-coupling. The catalytic chemoselective activation of 2-acylimidazole over bidentate coordinative and much more acidic malonate diester was particular noteworthy. Catalytic oxidative cross-enolate coupling of two distinct carboxylic acid equivalents was also achieved using acetonitrile as a coupling partner..
9.	Takafumi Tanaka, Tsukushi Tanaka, Taro Tsuji, Ryo Yazaki, Takashi Ohshima, Strategy for Catalytic Chemoselective Cross-Enolate Coupling Reaction via a Transient Homocoupling Dimer, Organic Letters, 10.1021/acs.orglett.8b01313, 20, 12, 3541-3544, 2018.06, [URL], A new strategy, a transient homocoupling dimer strategy, for direct catalytic oxidative cross-enolate coupling reactions is developed. Cross-enolate coupling products bearing a (contiguous) tetrasubstituted carbon center were obtained chemoselectively without the need for stoichiometric amounts of strong bases/metal oxidants, and thus, the present catalysis provides a general method for the synthesis of unnatural α,α-disubstituted amino acid motifs. The distinct transformation of azlactone and 2-acylimidazole units highlighted the synthetic utility of the present catalysis..

主要学会発表等

1.	田中津久志、橋口佳代子、田中尊書、矢崎亮、大嶋孝志, カルボン酸等価体の触媒的酸化的α-ベンジル化反応, 第36回有機合成化学セミナー, 2019.09.

所属学会名

学術論文等の審査

科学技術分野の文部科学大臣表彰 若手科学者賞, 2023.04.

Chemist Award BCA, 2022.12.

宇部興産学術振興財団第６０回学術奨励賞, 公益財団法人　宇部興産学術振興財団, 2020.04.

日本薬学会奨励賞, 日本薬学会, 2019.12.

有機合成化学協会九州・山口支部優秀論文賞, 公益財団法人　有機合成化学協会九州・山口支部, 2016.05.

有機合成化学協会　宇部興産研究企画賞, 公益財団法人　有機合成化学協会, 2015.02.

第２９回井上研究奨励賞, 公益法人井上科学振興財団, 2013.02.