Kyushu University [Murayama Keitaro (Lecturer) Kyushu University Hospital, Neuro-Psychiatry]

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Researcher information

Murayama Keitaro
Lecturer
Neuro-Psychiatry
Kyushu University Hospital
Last modified date：2024.04.09

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Research

Research Interests

Biophysiology of Obsessive-Compulsive Disorder
keyword : 　Obsessive-Compulsive Disorder
2018.04～2021.03.
psychiatric symptom after COVID-19
keyword : post COVID-19 condition, mental health, psychological first aid
2022.04～2025.03.
Biophysiology of Obsessive-Compulsive Disorder
keyword : 　Obsessive-Compulsive Disorder
2017.04～2018.03.
Biophysiology of Obsessive-Compulsive Disorder
keyword : 　Obsessive-Compulsive Disorder
2016.04～2017.03.
Biophysiology of Obsessive-Compulsive Disorder
keyword : 　Obsessive-Compulsive Disorder
2010.04～2015.06.

Academic Activities

Papers

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Keitaro Murayama, Tomohiro Nakao, Aikana Ohono, Sae Tsuruta, Hirofumi Tomiyama, Suguru Hasuzawa, Taro Mizobe, Kenta Kato and Sigenobu Kanba, Impacts of Stressful Life Events and Traumatic Experiences on Onset of Obsessive-Compulsive Disorder., Frontiers in Psychiatry, 2020.11.

Keitaro Murayama, Tomohiro Nakao, Sanematsu Hirokuni, Kayo Okada, Takashi Yoshiura, Mayumi Tomita, Yusuke Masuda, Kayoko Isomura, Akiko Nakagawa, Shigenobu Kanba, Differential neural network of checking versus washing symptoms in obsessive-compulsive disorder., Progess in Neuropsychopharmacolgy & Biological Psychiatry, 10, 40, 160-166, 2013.10, Obsessive-compulsive disorder (OCD) is clinically heterogeneous. The aim of this study was to investigate differential neural responses to a symptom provocation task in drug-free patients who have predominantly aggression/checking symptoms (Checkers) and patients with contamination/washing symptoms (Washers). We compared the Checkers (n=10) and the Washers (n=12) separately to normal controls during the symptom provocation tasks using fMRI (functional magnetic resonance imaging). Moreover, we performed correlative analysis in each OCD group between brain activation and symptom severity. The Checkers showed hypoactivation in the left caudate and left anterior cingulate cortex (ACC) compared to the normal controls and a positive correlation between activated brain areas and symptom severity in the left ACC. The Washers showed hyperactivation in several bilateral cortico-cerebellar regions and a positive correlation between symptom severity and the bilateral fronto-temporal gyrus. We suggest that the caudate and ACC are associated with checking rituals and that large cortical brain regions are related to washing rituals..

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