Kyushu University [Jun Hata (Professor) Faculty of Medical Sciences, Department of Basic Medicine]

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Jun Hata
Professor
Department of Health Care Administration and Management
Department of Basic Medicine
Faculty of Medical Sciences
Last modified date：2024.05.01

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Department of Health Care Administration and Management
Graduate School of Medical Sciences

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Department of Medicine
School of Medicine

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Center for Cohort Studies

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1.	Hata J, Tanizaki Y, Kiyohara Y, Kato I, Kubo M, Tanaka K, Okubo K, Nakamura H, Oishi Y, Ibayashi S, Iida M., Ten year recurrence after first ever stroke in a Japanese community: the Hisayama Study, J Neurol Neurosurg Psychiatry, 10.1136/jnnp.2004.038166, 76(3):368-372, 2005.03.
2.	Hata J, Matsuda K, Ninomiya T, Yonemoto K, Matsushita T, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Iida M, Kiyohara Y, Nakamura Y, Kubo M., Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction, Hum Mol Genet, 10.1093/hmg/ddm005, 16(6):630-639, 2007.03.
3.	Kubo M, Hata J, Doi Y, Tanizaki Y, Iida M, Kiyohara Y., Secular trends in the incidence of and risk factors for ischemic stroke and its subtypes in Japanese population, Circulation, 10.1161/CIRCULATIONAHA.107.743211, 118(25):2672-2678, 2008.12.
4.	Hata J, Doi Y, Ninomiya T, Tanizaki Y, Yonemoto K, Fukuhara M, Kubo M, Kitazono T, Iida M, Kiyohara Y., The effect of metabolic syndrome defined by various criteria on the development of ischemic stroke subtypes in a general Japanese population, Atherosclerosis, 10.1016/j.atherosclerosis.2009.10.044, 210(1):249-255, 2010.05.
5.	Hata J, Doi Y, Ninomiya T, Fukuhara M, Ikeda F, Mukai N, Hirakawa Y, Kitazono T, Kiyohara Y., Combined effects of smoking and hypercholesterolemia on the risk of stroke and coronary heart disease in Japanese: the Hisayama Study, Cerebrovasc Dis, 10.1159/000324392, 31(5):477-484, 2011.01.
6.	Hata J, Arima H, Zoungas S, Fulcher G, Pollock C, Adams M, Watson J, Joshi R, Kengne AP, Ninomiya T, Anderson C, Woodward M, Patel A, Mancia G, Poulter N, MacMahon S, Chalmers J, Neal B; ADVANCE Collaborative Group., Effects of the endpoint adjudication process on the results of a randomised controlled trial: the ADVANCE trial, PLoS One, 10.1371/journal.pone.0055807, 8(2):e55807, 2013.01.
7.	Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y., Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009), Circulation, 10.1161/CIRCULATIONAHA.113.002424, 128(11):1198-1205, 2013.09.
8.	Hata J, Arima H, Rothwell PM, Woodward M, Zoungas S, Anderson C, Patel A, Neal B, Glasziou P, Hamet P, Mancia G, Poulter N, Williams B, Macmahon S, Chalmers J; ADVANCE Collaborative Group., Effects of visit-to-visit variability in systolic blood pressure on macrovascular and microvascular complications in patients with type 2 diabetes mellitus: the ADVANCE trial, Circulation, 10.1161/CIRCULATIONAHA.113.002717, 128(12):1325-1334, 2013.09.
9.	Hata J, Mukai N, Nagata M, Ohara T, Yoshida D, Kishimoto H, Shibata M, Hirakawa Y, Endo M, Ago T, Kitazono T, Oike Y, Kiyohara Y, Ninomiya T., Serum angiopoietin-like protein 2 is a novel risk factor for cardiovascular disease in the community: the Hisayama Study, Arterioscler Thromb Vasc Biol, 10.1161/ATVBAHA.116.307291, 36(8):1686-1691, 2016.08.
10.	Hata J, Nagai A, Hirata M, Kamatani Y, Tamakoshi A, Yamagata Z, Muto K, Matsuda K, Kubo M, Nakamura Y; Biobank Japan Cooperative Hospital Group, Kiyohara Y, Ninomiya T., Risk prediction models for mortality in patients with cardiovascular disease: the BioBank Japan project, J Epidemiol, 10.1016/j.je.2016.10.007, 27(3S):S71-S76, 2017.03.
11.	Hata J, Fukuhara M, Sakata S, Arima H, Hirakawa Y, Yonemoto K, Mukai N, Kitazono T, Kiyohara Y, Ninomiya T., White-coat and masked hypertension are associated with albuminuria in a general population: the Hisayama Study, Hypertens Res, 10.1038/hr.2017.74, 40(11):937-943, 2017.11.
12.	Hata J, Ohara T, Katakura Y, Shimizu K, Yamashita S, Yoshida D, Honda T, Hirakawa Y, Shibata M, Sakata S, Kitazono T, Kuhara S, Ninomiya T., Association between serum β-alanine and risk of dementia, Am J Epidemiol, 10.1093/aje/kwz116, 188(9):1637-1645, 2019.09.
13.	Hata J, Nagata T, Sakata S, Oishi E, Furuta Y, Hirakawa Y, Honda T, Yoshida D, Kitazono T, Ninomiya T., Risk prediction model for incident atrial fibrillation in a general Japanese population: the Hisayama Study, Circ J, 10.1253/circj.CJ-20-0794, 85(8):1373-1382, 2021.07, Background: The risk prediction of incident atrial fibrillation (AF) is useful to prevent AF and its complications. The aim of this study is to develop a new risk prediction model for incident AF using the prospective longitudinal data from a general Japanese population. Methods and Results: A total of 2,442 community-dwelling AF-free residents aged ≥40 years were followed up from 1988 to 2012 (46,422 person-years). The development of AF was confirmed by a standard 12-lead electrocardiogram at repeated health examinations and by medical records at clinics or hospitals. The risk prediction model for incident AF was developed using a Cox proportional hazards model. During the follow up, 230 AF events were confirmed. Age, sex, systolic blood pressure, waist circumference, estimated glomerular filtration rate, abnormal cardiac murmur, high R-wave amplitude, and arrhythmia other than AF were selected for inclusion in the model. This model showed good discrimination (Harrell's c statistics: 0.785) and calibration (Greenwood-Nam-D'Agostino test: P=0.87) for AF risk at 10 years. Conclusions: The new risk prediction model showed good performance on the individual risk assessment of the future onset of AF in a general Japanese population. As this model included commonly used clinical parameters, it may be useful for determining the requirements for the careful evaluation of AF, such as frequent electrocardiogram examinations in clinical settings, and subsequent reductions in the risk of AF-related complications..

1.	Hata J，Ninomiya T. , Risk factors for carotid atherosclerosis: the Hisayama Study. , 第49回日本動脈硬化学会総会・学術集会, 2017.07.
2.	Hata J，Kiyohara Y, Diabetes mellitus as a risk factor for cancer: the Hisayama Study, 第72回日本癌学会学術総会, 2013.10.
3.	Hata J，Kiyohara Y, Stroke epidemiology in Japan: the Hisayama Study, 2nd Asia Pacific Stroke Conference, 2012.09.