Kyushu University [Tanaka Masatake (Assistant Professor) Kyushu University Hospital, Department of Hepatology and Pancreatology]

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Researcher information

Tanaka Masatake
Assistant Professor
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
Department of Hepatology and Pancreatology
Kyushu University Hospital
Last modified date：2024.06.03

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Academic Degree

Country of degree conferring institution (Overseas)

Field of Specialization

Total Priod of education and research career in the foreign country

Research

Research Interests

Development of a new method for prognosis prediction and pathophysiological stratification of acute liver injury and acute liver failure patients
keyword : acute liver failure (ALF), acute liver injury (ALI), prognosis prediction
2023.04.
The study for elucidating the mechanism of liver fibrosis in metabolic dysfunction-associated liver disease
keyword : Metabolic dysfunction-associated steatohepatitis, MASH, fibrosis, crown-like structure, ballooning hepatocyte, single cell-RNA seq
2018.10.
The establishment of a cooperative medical system for Fontan-associated liver disease (FALD) patients and the basic study for elucidating the mechanism of fibrosis of FALD liver
keyword : Fontan-associated liver disease, FALD, fibrosis, cooperative medical system, mouse model, hypoxia, shear stress
2018.10.
Analysis of the functions of the vascular and lymphatic vascular systems as the pathogeneses of various liver diseases
keyword : Liver diseases, Liver fibrosis, Cirrhosis, Vascular system, Lymphatic vascular system, Microcirculation, metabolic dysfunction-associated steatohepatitis, MASH, non-alcoholic steatohepatitis, NASH
2018.10.

Academic Activities

Reports

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1.	Jain Jeong, Masatake Tanaka, Yasuko Iwakiri, Hepatic lymphatic vascular system in health and disease, Journal of Hepatology, DOI: 10.1016/j.jhep.2022.01.025, 2022.02, In recent years, significant advances have been made in the study of lymphatic vessels with the identification of their specific markers and the development of research tools that have accelerated our understanding of their role in tissue homeostasis and disease pathogenesis in many organs. Compared to other organs, the lymphatic system in the liver is understudied despite its obvious importance for hepatic physiology and pathophysiology. In this review, we describe fundamental aspects of the hepatic lymphatic system and its role in a range of liver-related pathological conditions such as portal hypertension, ascites formation, malignant tumours, liver transplantation, congenital liver diseases, non-alcoholic fatty liver disease, and hepatic encephalopathy. The article concludes with a discussion regarding the modulation of lymphangiogenesis as a potential therapeutic strategy for liver diseases..
2.	Masatake Tanaka, Yasuko Iwakiri, Lymphatics in the liver, Current Opinion in Immunology, 10.1016/j.coi.2018.04.028, 2018.08, The liver is the largest lymph producing organ. A significant increase in the number of hepatic lymphatic vessels, or lymphangiogenesis, has been reported in various liver diseases, including, but not limited to, cirrhosis, viral hepatitis and hepatocellular carcinoma. Despite its apparent relevance in healthy and diseased livers as these and other observations indicate, the hepatic lymphatic system has been poorly studied. With knowledge of the lymphatic system in other organs and tissues incorporated, this review article addresses the current knowledge of the hepatic lymphatic system and the potential role of lymphatic endothelial cells in the health and the disease of the liver and concludes with a brief description on future directions of the study of the hepatic lymphatic system..
3.	Masatake Tanaka, Yasuko Iwakiri, The Hepatic Lymphatic Vascular System Structure, Function, Markers, and Lymphangiogenesis, CMGH, 10.1016/j.jcmgh.2016.09.002, 2016.11, The lymphatic vascular system has been minimally explored in the liver despite its essential functions including maintenance of tissue fluid homeostasis. The discovery of specific markers for lymphatic endothelial cells has advanced the study of lymphatics by methods including imaging, cell isolation, and transgenic animal models and has resulted in rapid progress in lymphatic vascular research during the last decade. These studies have yielded concrete evidence that lymphatic vessel dysfunction plays an important role in the pathogenesis of many diseases. This article reviews the current knowledge of the structure, function, and markers of the hepatic lymphatic vascular system as well as factors associated with hepatic lymphangiogenesis and compares liver lymphatics with those in other tissues..

Papers

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Presentations

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Membership in Academic Society

THE JAPANESE SOCIETY OF INTERNAL MEDICINE
JAPANESE SOCIETY OF GASTROENTEROLOGY
THE JAPAN SOCIETY OF HEPATOLOGY
The Japan Society for Portal Hypertension
JAPANESE SOCIETY OF MEDICAL ONCOLOGY
Japanese Society of Adult Congenital Heart Disease
American Association for the Study of Liver Diseases (AASLD)

Awards

Doctor of Distinct
Postdoctoral Research Fellowship
Pilot Feasibility Grant

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