Updated on 2024/10/04

Information

 

写真a

 
HIRAMATSU KOTARO
 
Organization
Faculty of Science Department of Chemistry Associate Professor
School of Sciences Department of Chemistry（Joint Appointment）
Graduate School of Sciences Department of Chemistry（Joint Appointment）
Title
Associate Professor
Contact information
メールアドレス
Tel
0928024189
External link

Degree

  • Ph.D.

Research History

  • 2011年3月 東京大学理学部化学科卒業 2013年3月 東京大学大学院理学系研究科化学専攻　修士課程修了 2013年4月-2016年3月 日本学術振興会特別研究員DC1 2016年3月 東京大学大学院理学系研究科化学専攻　博士課程修了 2016年3月 東京大学フォトンサイエンスリーディング大学院　修了 2016年4月 - 2016年8月 理化学研究所田原分子分光研究室　基礎科学特別研究員 2016年9月 - 現在 東京大学大学院理学系研究科化学専攻 スペクトル化学研究センター　助教 2018年10月 – 2022年3月 国立研究開発法人科学技術振興機構　さきがけ研究員

Research Interests・Research Keywords

  • Research theme：We are engaged in the development of methods to efficiently explore unexplored temporal, spatial, and energy domains by integrating optical measurement and information processing. Specifically, we are developing methodologies for the creation of new useful strains by combining large-scale cell measurement and sorting with genetic mutation, and for providing feedback to material design guidelines by elucidating the material destruction process through high-speed and long-term measurement of spectra. By maximizing the potential of light, we are working to discover new phenomena and elucidate their mechanisms by creating a chemical eye that makes the previously invisible visible.

    Keyword：Molecular spectroscopy, laser engineering, vibrational spectroscopy, superresolution microscopy, bioimaging, ultrafast spectroscopy

    Research period： 2023.10

Awards

  • 日本分光学会奨励賞

    2024.6   日本分光学会   ラマン分光フローサイトメトリーの開発と大規模細胞解析

  • コニカミノルタ画像科学奨励賞 連携賞

    2024.2   コニカミノルタ科学技術振興財団   高速超解像イメージングのための空間―周波数圧縮顕微鏡の開発

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    2014年にノーベル化学賞を受賞したBetzig, Moernerらによって開発されたSingle-molecule localization microscopy (SMLM)は，通常の光学顕微鏡の10倍以上の空間分解能を有し，細胞内の個別のタンパク質の局在を可視化することができる．しかしながら，SMLMでは1つの超解像画像を取得するのに，蛍光を明滅させながら数千回から数万回の撮像（1回の撮像を30ミリ秒としても，数十秒から数分を要する）を行う必要があり，細胞内分子の動態を計測することは困難である．本研究では，明滅の代わりに焦点内の各プローブ分子からの信号を分光学的に分離することで、シングルショットSMLM撮像を実現する．具体的には，空間―周波数圧縮ラマン顕微鏡（光と画像に関するシステム）とスペクトルの線形独立性と空間的なスパース性を用いたデータ解析法（光と画像に関するソフトウェア）を開発・融合することによりプローブ分子の位置を超精度で決定できるSMARTS: Superresolution Microscopy with Advanced Raman Tags and Sparse modelingを創出する．それにより超解像計測の時間分解能を飛躍的に向上させ，細胞内輸送などの時空間的に複雑な構造をもつ生命現象の原理解明に向けた技術基盤を確立することを目指す．

  • 光学論文賞

    2023.11   日本光学会   Ultrafast, dual-band coherent Raman spectroscopy without ultrashort pulses

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    コヒーレントラマン分光法は、高速かつ無標識に分子レベルの構造情報を得られる手法として近年注目を集めている。コヒーレントラマン分光法と顕微鏡を組み合わせた振動分光イメージングや、コヒーレントラマン分光法とフローサイトメトリーを組み合わせた大規模細胞解析法などがこれまでに実証されてきた。応募者らは超短パルスレーザーを用いて時間領域で分子振動を励起・検出するFourier-transform coherent Raman scattering (FT-CARS)法を用いて、高速（24,000 spectra/s）かつ広帯域（200 – 1600 cm-1）な振動分光計測を実現するとともに、様々な対象へとその応用を実証してきた。しかしながら、周波数領域で計測を行うCARS分光法やStimulated Raman scattering （SRS）法などと比較したときに、FT-CARS法では、CH伸縮振動が観測される高波数領域（2800 – 3400 cm-1）が計測できないといった欠点があった。

    本研究では、これまでに開発してきたFT-CARS法に用いているチタンサファイアレーザーに同期して発振するYbファイバーレーザー（YbF）を併せて光源として用いることで、FT-CARS法でも高波数領域の計測が可能であることを実証した。これまでのFT-CARS計測では、パルス幅15 fs程度のチタンサファイアレーザー（TiS）からの出力(750 – 850 nm)をpump光とprobe光へと分割し、それらを様々なパルス間隔でサンプルへと照射することで、分子振動の時間発展を計測していた。今回開発した手法では、従来のFT-CARS分光計をベースとして、YbFからの出力（~1030 nm）を同時に照射することで、CH伸縮領域の計測を可能とした。TiSの出力の一部をYbFのキャビティ内へと導入し、相互位相変調によってYbFキャビティ内で2つのパルスが同じ群速度で伝搬しYbFとTiSの高精度な同期発振を実現した。

  • 日本分光学会年次講演会若手講演賞

    2021.11  

  • 研究開発奨励賞 エヌエフホールディングス特別賞

    2020.12   エヌエフ基金   振動分光計測に基づく無標識・大規模一細胞解析法の開発

  • 優秀講演賞(学術)

    2019.4   日本化学会  

  • 第47回（2019年秋季）応用物理学会講演奨励賞

    2019.3  

  • Best Presentation Award, SPIE Photonics West

    2019.2   SPIE   Best Presentation Award, SPIE Photonics West

  • 理学系研究科研究奨励賞

    2016.3   東京大学  

  • Springer Thesis Award

    2016.3   Springer Thesis Award

  • 第9回分子科学討論会 優秀講演賞

    2015.10  

  • Poster Award, 15th International Conference on Chiroptical Spectroscopy (CD2015)

    2015.9   Poster Award, 15th International Conference on Chiroptical Spectroscopy (CD2015)

  • 日本分光学会年次講演会若手講演賞

    2015.6   日本分光学会  

  • 日本化学会 第95春季年会 (2015)学生講演賞

    2015.3  

  • 第6回分子科学討論会優秀講演賞

    2012.9  

  • Best Poster Award, 3rd Asian Spectroscopy Conference

    2011.12   Best Poster Award, 3rd Asian Spectroscopy Conference

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Papers

  • High-throughput fluorescence lifetime imaging flow cytometry. International journal

    Hiroshi Kanno, Kotaro Hiramatsu, Hideharu Mikami, Atsushi Nakayashiki, Shota Yamashita, Arata Nagai, Kohki Okabe, Fan Li, Fei Yin, Keita Tominaga, Omer Faruk Bicer, Ryohei Noma, Bahareh Kiani, Olga Efa, Martin Büscher, Tetsuichi Wazawa, Masahiro Sonoshita, Hirofumi Shintaku, Takeharu Nagai, Sigurd Braun, Jessica P Houston, Sherif Rashad, Kuniyasu Niizuma, Keisuke Goda

    Nature communications   15 ( 1 )   7376 - 7376   2024.9

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    Flow cytometry is a vital tool in biomedical research and laboratory medicine. However, its accuracy is often compromised by undesired fluctuations in fluorescence intensity. While fluorescence lifetime imaging microscopy (FLIM) bypasses this challenge as fluorescence lifetime remains unaffected by such fluctuations, the full integration of FLIM into flow cytometry has yet to be demonstrated due to speed limitations. Here we overcome the speed limitations in FLIM, thereby enabling high-throughput FLIM flow cytometry at a high rate of over 10,000 cells per second. This is made possible by using dual intensity-modulated continuous-wave beam arrays with complementary modulation frequency pairs for fluorophore excitation and acquiring fluorescence lifetime images of rapidly flowing cells. Moreover, our FLIM system distinguishes subpopulations in male rat glioma and captures dynamic changes in the cell nucleus induced by an anti-cancer drug. FLIM flow cytometry significantly enhances cellular analysis capabilities, providing detailed insights into cellular functions, interactions, and environments.

    DOI： 10.1038/s41467-024-51125-y

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  • Fluorescence-Encoded Time-Domain Coherent Raman Spectroscopy in the Visible Range

    Tetsu Tamura, Phillip C. McCann, Ryo Nishiyama, Kotaro Hiramatsu, Keisuke Goda

    The Journal of Physical Chemistry Letters   15 ( 18 )   4940 - 4947   2024.4   （ ISSN:1948-7185 ）

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    DOI： 10.1021/acs.jpclett.4c00817

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  • The marriage of coherent Raman scattering imaging and advanced computational tools

    Walker Peterson, Kotaro Hiramatsu, Keisuke Goda

    Light: Science and Applications   12 ( 1 )   2023.12   （ ISSN:2095-5545 eISSN:2047-7538 ）

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    Language：Others   Publishing type：Research paper (scientific journal)  

    Coherent Raman scattering microscopy can provide high-contrast tissue and single-cell images based on the inherent molecular vibrations of the sample. However, conventional techniques face a three-way trade-off between Raman spectral bandwidth, imaging speed, and image fidelity. Although currently challenging to address via optical design, this trade-off can be overcome via emerging computational tools such as compressive sensing and machine learning.

    DOI： 10.1038/s41377-023-01160-z

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  • Boosting the Brightness of Raman Tags Using Cyanostar Macrocycles

    Ryo Nishiyama, Kei Furuya, Phillip McCann, Laura Kacenauskaite, Bo W. Laursen, Amar H. Flood, Kotaro Hiramatsu, Keisuke Goda

    Analytical Chemistry   95 ( 34 )   12835 - 12841   2023.8   （ ISSN:0003-2700 eISSN:1520-6882 ）

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    Language：Others   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acs.analchem.3c01958

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  • Label-free live microalgal starch screening via Raman flow cytometry

    Julia Gala de Pablo, Matthew Lindley, Kotaro Hiramatsu, Akihiro Isozaki, Keisuke Goda

    Algal Research   2023.3

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    DOI： 10.1016/j.algal.2023.102993

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  • High-speed hyperspectral imaging enabled by compressed sensing in time domain

    Shigekazu Takizawa, Kotaro Hiramatsu, Matthew Lindley, Julia Gala de Pablo, Shunsuke Ono, Keisuke Goda

    Advanced Photonics Nexus   2 ( 02 )   2023.3   （ ISSN:2791-1519 ）

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    Language：Others   Publishing type：Research paper (scientific journal)   Publisher：SPIE-Intl Soc Optical Eng  

    DOI： 10.1117/1.apn.2.2.026008

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  • Place & Play SERS: sample collection and preparation-free surface-enhanced Raman spectroscopy

    Yasutaka Kitahama, Pablo Martinez Pancorbo, Hiroki Segawa, Machiko Marumi, Ting-Hui Xiao, Kotaro Hiramatsu, William Yang, Keisuke Goda

    ANALYTICAL METHODS   15 ( 8 )   1028 - 1036   2023.2   （ ISSN:1759-9660 eISSN:1759-9679 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：ROYAL SOC CHEMISTRY  

    The ability to perform sensitive, real-time, in situ, multiplex chemical analysis is indispensable for diverse applications such as human health monitoring, food safety testing, forensic analysis, environmental sensing, and homeland security. Surface-enhanced Raman spectroscopy (SERS) is an effective tool to offer the ability by virtue of its high sensitivity and rapid label-free signal detection as well as the availability of portable Raman spectrometers. Unfortunately, the practical utility of SERS is limited because it generally requires sample collection and preparation, namely, collecting a sample from an object of interest and placing the sample on top of a SERS substrate to perform a SERS measurement. In fact, not all analytes can satisfy this requirement because the sample collection and preparation process may be undesirable, laborious, difficult, dangerous, costly, or time-consuming. Here we introduce "Place & Play SERS" based on an ultrathin, flexible, stretchable, adhesive, biointegratable gold-deposited polyvinyl alcohol (PVA) nanomesh substrate that enables placing the substrate on top of an object of interest and performing a SERS measurement of the object by epi-excitation without the need for touching, destroying, and sampling it. Specifically, we characterized the sensitivity of the gold/PVA nanomesh substrate in the Place & Play SERS measurement scheme and then used the scheme to conduct SERS measurements of both wet and dry objects under nearly real-world conditions. To show the practical utility of Place & Play SERS, we demonstrated two examples of its application: food safety testing and forensic analysis. Our results firmly verified the new measurement scheme of SERS and are expected to extend the potential of SERS by opening up untapped applications of sensitive, real-time, in situ multiplex chemical analysis.

    DOI： 10.1039/d2ay02090d

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  • Color-scalable flow cytometry with Raman tags. International journal

    Ryo Nishiyama, Kotaro Hiramatsu, Shintaro Kawamura, Kosuke Dodo, Kei Furuya, Julia Gala de Pablo, Shigekazu Takizawa, Wei Min, Mikiko Sodeoka, Keisuke Goda

    PNAS nexus   2 ( 2 )   pgad001   2023.2

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    Flow cytometry is an indispensable tool in biology and medicine for counting and analyzing cells in large heterogeneous populations. It identifies multiple characteristics of every single cell, typically via fluorescent probes that specifically bind to target molecules on the cell surface or within the cell. However, flow cytometry has a critical limitation: the color barrier. The number of chemical traits that can be simultaneously resolved is typically limited to several due to the spectral overlap between fluorescence signals from different fluorescent probes. Here, we present color-scalable flow cytometry based on coherent Raman flow cytometry with Raman tags to break the color barrier. This is made possible by combining a broadband Fourier-transform coherent anti-Stokes Raman scattering (FT-CARS) flow cytometer, resonance-enhanced cyanine-based Raman tags, and Raman-active dots (Rdots). Specifically, we synthesized 20 cyanine-based Raman tags whose Raman spectra are linearly independent in the fingerprint region (400 to 1,600 cm-1). For highly sensitive detection, we produced Rdots composed of 12 different Raman tags in polymer nanoparticles whose detection limit was as low as 12 nM for a short FT-CARS signal integration time of 420 µs. We performed multiplex flow cytometry of MCF-7 breast cancer cells stained by 12 different Rdots with a high classification accuracy of 98%. Moreover, we demonstrated a large-scale time-course analysis of endocytosis via the multiplex Raman flow cytometer. Our method can theoretically achieve flow cytometry of live cells with >140 colors based on a single excitation laser and a single detector without increasing instrument size, cost, or complexity.

    DOI： 10.1093/pnasnexus/pgad001

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  • Label-free multiphoton imaging flow cytometry. International journal

    Ryo Kinegawa, Julia Gala de Pablo, Yi Wang, Kotaro Hiramatsu, Keisuke Goda

    Cytometry. Part A : the journal of the International Society for Analytical Cytology   2023.2

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    Label-free imaging flow cytometry is a powerful tool for biological and medical research as it overcomes technical challenges in conventional fluorescence-based imaging flow cytometry that predominantly relies on fluorescent labeling. To date, two distinct types of label-free imaging flow cytometry have been developed, namely optofluidic time-stretch quantitative phase imaging flow cytometry and stimulated Raman scattering (SRS) imaging flow cytometry. Unfortunately, these two methods are incapable of probing some important molecules such as starch and collagen. Here, we present another type of label-free imaging flow cytometry, namely multiphoton imaging flow cytometry, for visualizing starch and collagen in live cells with high throughput. Our multiphoton imaging flow cytometer is based on nonlinear optical imaging whose image contrast is provided by two optical nonlinear effects: four-wave mixing (FWM) and second-harmonic generation (SHG). It is composed of a microfluidic chip with an acoustic focuser, a lab-made laser scanning SHG-FWM microscope, and a high-speed image acquisition circuit to simultaneously acquire FWM and SHG images of flowing cells. As a result, it acquires FWM and SHG images (100 × 100 pixels) with a spatial resolution of 500 nm and a field of view of 50 μm × 50 μm at a high event rate of four to five events per second, corresponding to a high throughput of 560-700 kb/s, where the event is defined by the passage of a cell or a cell-like particle. To show the utility of our multiphoton imaging flow cytometer, we used it to characterize Chromochloris zofingiensis (NIES-2175), a unicellular green alga that has recently attracted attention from the industrial sector for its ability to efficiently produce valuable materials for bioplastics, food, and biofuel. Our statistical image analysis found that starch was distributed at the center of the cells at the early cell cycle stage and became delocalized at the later stage. Multiphoton imaging flow cytometry is expected to be an effective tool for statistical high-content studies of biological functions and optimizing the evolution of highly productive cell strains.

    DOI： 10.1002/cyto.a.24723

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  • Ultrafast, Dual-Band Coherent Raman Spectroscopy without Ultrashort Pulses

    Kotaro Hiramatsu, Tatsuya Tajima, Keisuke Goda

    ACS Photonics   9 ( 11 )   3522 - 3528   2022.10   （ ISSN:2330-4022 eISSN:2330-4022 ）

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    DOI： 10.1021/acsphotonics.2c00768

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  • Highly Scalable, Wearable Surface-Enhanced Raman Spectroscopy

    Limei Liu, Pablo Martinez Pancorbo, Ting Hui Xiao, Saya Noguchi, Machiko Marumi, Hiroki Segawa, Siddhant Karhadkar, Julia Gala de Pablo, Kotaro Hiramatsu, Yasutaka Kitahama, Tamitake Itoh, Junle Qu, Kuniharu Takei, Keisuke Goda

    Advanced Optical Materials   10 ( 17 )   2022.9   （ eISSN:2195-1071 ）

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    The last two decades have witnessed a dramatic growth of wearable sensor technology, mainly represented by flexible, stretchable, on-skin electronic sensors that provide rich information of the wearer's health conditions and surroundings. A recent breakthrough in the field is the development of wearable chemical sensors based on surface-enhanced Raman spectroscopy (SERS) that can detect molecular fingerprints universally, sensitively, and noninvasively. However, while their sensing properties are excellent, these sensors are not scalable for widespread use beyond small-scale human health monitoring due to their cumbersome fabrication process and limited multifunctional sensing capabilities. Here, a highly scalable, wearable SERS sensor is demonstrated based on an easy-to-fabricate, low-cost, ultrathin, flexible, stretchable, adhesive, and biointegratable gold nanomesh. It can be fabricated in any shape and worn on virtually any surface for label-free, large-scale, in situ sensing of diverse analytes from low to high concentrations (10–106 × 10−9 m). To show the practical utility of the wearable SERS sensor, the sensor is tested for the detection of sweat biomarkers, drugs of abuse, and microplastics. This wearable SERS sensor represents a significant step toward the generalizability and practicality of wearable sensing technology.

    DOI： 10.1002/adom.202200054

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  • Intelligent sort‐timing prediction for image‐activated cell sorting

    Yaqi Zhao, Akihiro Isozaki, Maik Herbig, Mika Hayashi, Kotaro Hiramatsu, Sota Yamazaki, Naoko Kondo, Shinsuke Ohnuki, Yoshikazu Ohya, Nao Nitta, Keisuke Goda

    Cytometry Part A   2022.6   （ ISSN:1552-4922 eISSN:1552-4930 ）

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    Language：Others   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1002/cyto.a.24664

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    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/cyto.a.24664

  • High‐Throughput Raman‐Activated Cell Sorting in the Fingerprint Region

    Matthew Lindley, Julia Gala de Pablo, Walker Peterson, Akihiro Isozaki, Kotaro Hiramatsu, Keisuke Goda

    Advanced Materials Technologies   2101567 - 2101567   2022.4   （ ISSN:2365-709X eISSN:2365-709X ）

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    Language：Others   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    DOI： 10.1002/admt.202101567

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    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/admt.202101567

  • Ultrafast impulsive Raman spectroscopy across the terahertz-fingerprint region

    Walker Peterson, Julia Gala De Pablo, Matthew Lindley, Kotaro Hiramatsu, Keisuke Goda

    Advanced Photonics   4 ( 1 )   2022.1   （ eISSN:2577-5421 ）

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    Broadband Raman spectroscopy (detection bandwidth >1000 cm-1) is a valuable and widely used tool for understanding samples via label-free measurements of their molecular vibrations. Two important Raman spectral regions are the chemically specific "fingerprint"(200 to 1800 cm-1) and "low-frequency"or "terahertz"(THz) (<200 cm-1; <6 THz) regions, which mostly contain intramolecular and intermolecular vibrations, respectively. These two regions are highly complementary; broadband simultaneous measurement of both regions can provide a big picture comprising information about molecular structures and interactions. Although techniques for acquiring broadband Raman spectra covering both regions have been demonstrated, these methods tend to have spectral acquisition rates <10 spectra/s, prohibiting high-speed applications, such as Raman imaging or vibrational detection of transient phenomena. Here, we demonstrate a single-laser method for ultrafast (24,000 spectra/s) broadband Raman spectroscopy covering both THz and fingerprint regions. This is achieved by simultaneous detection of Sagnac-enhanced impulsive stimulated Raman scattering (SE-ISRS; THz-sensitive) and Fourier-transform coherent anti-Stokes Raman scattering (FT-CARS; fingerprint-sensitive). With dual-detection impulsive vibrational spectroscopy, the SE-ISRS signal shows a >500 × enhancement of <6.5 THz sensitivity compared with that of FT-CARS, and the FT-CARS signal shows a >10 × enhancement of fingerprint sensitivity above 1000 cm-1 compared with that of SE-ISRS.

    DOI： 10.1117/1.AP.4.1.016003

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  • Massive image-based single-cell profiling reveals high levels of circulating platelet aggregates in patients with COVID-19

    Masako Nishikawa, Hiroshi Kanno, Yuqi Zhou, Ting Hui Xiao, Takuma Suzuki, Yuma Ibayashi, Jeffrey Harmon, Shigekazu Takizawa, Kotaro Hiramatsu, Nao Nitta, Risako Kameyama, Walker Peterson, Jun Takiguchi, Mohammad Shifat-E-Rabbi, Yan Zhuang, Xuwang Yin, Abu Hasnat Mohammad Rubaiyat, Yunjie Deng, Hongqian Zhang, Shigeki Miyata, Gustavo K. Rohde, Wataru Iwasaki, Yutaka Yatomi, Keisuke Goda

    Nature Communications   12 ( 1 )   2021.12

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    DOI： 10.1038/s41467-021-27378-2

  • Highly sensitive Fourier-transform coherent anti-Stokes Raman scattering spectroscopy via genetic algorithm pulse shaping. Reviewed International journal

    Matthew Lindley, Julia Gala de Pablo, Ryo Kinegawa, Kotaro Hiramatsu, Keisuke Goda

    Optics letters   46 ( 17 )   4320 - 4323   2021.9

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    DOI： 10.1364/OL.434054

  • Highly Sensitive Low-Frequency Time-Domain Raman Spectroscopy via Fluorescence Encoding. Reviewed International journal

    Phillip C McCann, Kotaro Hiramatsu, Keisuke Goda

    The journal of physical chemistry letters   12 ( 32 )   7859 - 7865   2021.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acs.jpclett.1c01741

  • Morphological Indicator for Directed Evolution of Euglena gracilis with a High Heavy Metal Removal Efficiency. Reviewed International journal

    Muzhen Xu, Jeffrey Harmon, Dan Yuan, Sheng Yan, Cheng Lei, Kotaro Hiramatsu, Yuqi Zhou, Mun Hong Loo, Tomohisa Hasunuma, Akihiro Isozaki, Keisuke Goda

    Environmental science & technology   55 ( 12 )   7880 - 7889   2021.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acs.est.0c05278

  • High-Throughput Raman Flow Cytometry and Beyond. Reviewed International journal

    Julia Gala de Pablo, Matthew Lindley, Kotaro Hiramatsu, Keisuke Goda

    Accounts of chemical research   54 ( 9 )   2132 - 2143   2021.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acs.accounts.1c00001

  • All-dielectric chiral-field-enhanced Raman optical activity. Reviewed International journal

    Ting-Hui Xiao, Zhenzhou Cheng, Zhenyi Luo, Akihiro Isozaki, Kotaro Hiramatsu, Tamitake Itoh, Masahiro Nomura, Satoshi Iwamoto, Keisuke Goda

    Nature communications   12 ( 1 )   3062 - 3062   2021.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41467-021-23364-w

  • Dual-Comb Coherent Raman Spectroscopy with near 100&#37; Duty Cycle Reviewed International journal

    Risako Kameyama, Shigekazu Takizawa, Kotaro Hiramatsu, Keisuke Goda

    ACS PHOTONICS   8 ( 4 )   975 - 981   2021.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acsphotonics.0c01656

  • Porous carbon nanowire array for surface-enhanced Raman spectroscopy. Reviewed International journal

    Nan Chen, Ting-Hui Xiao, Zhenyi Luo, Yasutaka Kitahama, Kotaro Hiramatsu, Naoki Kishimoto, Tamitake Itoh, Zhenzhou Cheng, Keisuke Goda

    Nature communications   11 ( 1 )   4772 - 4772   2020.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41467-020-18590-7

  • Raman image-activated cell sorting Reviewed International journal

    Nao Nitta, Takanori Iino, Akihiro Isozaki, Mai Yamagishi, Yasutaka Kitahama, Shinya Sakuma, Yuta Suzuki, Hiroshi Tezuka, Minoru Oikawa, Fumihito Arai, Takuya Asai, Dinghuan Deng, Hideya Fukuzawa, Misa Hase, Tomohisa Hasunuma, Takeshi Hayakawa, Kei Hiraki, Kotaro Hiramatsu, Yu Hoshino, Mary Inaba, Yuki Inoue, Takuro Ito, Masataka Kajikawa, Hiroshi Karakawa, Yusuke Kasai, Yuichi Kato, Hirofumi Kobayashi, Cheng Lei, Satoshi Matsusaka, Hideharu Mikami, Atsuhiro Nakagawa, Keiji Numata, Tadataka Ota, Takeichiro Sekiya, Kiyotaka Shiba, Yoshitaka Shirasaki, Nobutake Suzuki, Shunji Tanaka, Shunnosuke Ueno, Hiroshi Watarai, Takashi Yamano, Masayuki Yazawa, Yusuke Yonamine, Dino Di Carlo, Yoichiroh Hosokawa, Sotaro Uemura, Takeaki Sugimura, Yasuyuki Ozeki, Keisuke Goda

    NATURE COMMUNICATIONS   11 ( 1 )   3452 - 3452   2020.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41467-020-17285-3

  • Intelligent image-activated cell sorting 2.0 Reviewed International journal

    Akihiro Isozaki, Hideharu Mikami, Hiroshi Tezuka, Hiroki Matsumura, Kangrui Huang, Marino Akamine, Kotaro Hiramatsu, Takanori Iino, Takuro Ito, Hiroshi Karakawa, Yusuke Kasai, Yan Li, Yuta Nakagawa, Shinsuke Ohnuki, Tadataka Ota, Yong Qian, Shinya Sakuma, Takeichiro Sekiya, Yoshitaka Shirasaki, Nobutake Suzuki, Ehsen Tayyabi, Tsubasa Wakamiya, Muzhen Xu, Mai Yamagishi, Haochen Yan, Qiang Yu, Sheng Yan, Dan Yuan, Wei Zhang, Yaqi Zhao, Fumihito Arai, Robert E. Campbell, Christophe Danelon, Dino Di Carlo, Kei Hiraki, Yu Hoshino, Yoichiroh Hosokawa, Mary Inaba, Atsuhiro Nakagawa, Yoshikazu Ohya, Minoru Oikawa, Sotaro Uemura, Yasuyuki Ozeki, Takeaki Sugimura, Nao Nitta, Keisuke Goda

    LAB ON A CHIP   20 ( 13 )   2263 - 2273   2020.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1039/d0lc00080a

  • Spatiotemporal monitoring of intracellular metabolic dynamics by resonance Raman microscopy with isotope labeling Reviewed International journal

    Yusuke Yonamine, Kotaro Hiramatsu, Takuro Ideguchi, Takuro Ito, Tomomi Fujiwara, Yoshiko Miura, Keisuke Goda, Yu Hoshino

    RSC ADVANCES   10 ( 28 )   16679 - 16686   2020.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1039/d0ra02803g

  • Large-scale label-free single-cell analysis of paramylon in Euglena gracilis by high-throughput broadband Raman flow cytometry. Reviewed International journal

    Kotaro Hiramatsu, Koji Yamada, Matthew Lindley, Kengo Suzuki, Keisuke Goda

    11 ( 4 )   1752 - 1759   2020.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    Large-scale label-free single-cell analysis of paramylon in Euglena gracilis by high-throughput broadband Raman flow cytometry.
    Microalga-based biomaterial production has attracted attention as a new source of drugs, foods, and biofuels. For enhancing the production efficiency, it is essential to understand its differences between heterogeneous microalgal subpopulations. However, existing techniques are not adequate to address the need due to the lack of single-cell resolution or the inability to perform large-scale analysis and detect small molecules. Here we demonstrated large-scale single-cell analysis of Euglena gracilis (a unicellular microalgal species that produces paramylon as a potential drug for HIV and colon cancer) with our recently developed high-throughput broadband Raman flow cytometer at a throughput of >1,000 cells/s. Specifically, we characterized the intracellular content of paramylon from single-cell Raman spectra of 10,000 E. gracilis cells cultured under five different conditions and found that paramylon contents in E. gracilis cells cultured in an identical condition is given by a log-normal distribution, which is a good model for describing the number of chemicals in a reaction network. The capability of characterizing distribution functions in a label-free manner is an important basis for isolating specific cell populations for synthetic biology via directed evolution based on the intracellular content of metabolites.

    DOI： 10.1364/BOE.382957

  • Compressed time-domain coherent Raman spectroscopy with real-time random sampling Reviewed International journal

    Shigekazu Takizawa, Kotaro Hiramatsu, Keisuke Goda

    VIBRATIONAL SPECTROSCOPY   107   2020.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.vibspec.2020.103042

  • Ultrafast Simultaneous Raman-Fluorescence Spectroscopy Reviewed International journal

    Matthew Lindley, Kotaro Hiramatsu, Hayate Nomoto, Fukashi Shibata, Tsuyoshi Takeshita, Shigeyuki Kawano, Keisuke Goda

    ANALYTICAL CHEMISTRY   91 ( 24 )   15563 - 15569   2019.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acs.analchem.9b03563

  • Sagnac-enhanced impulsive stimulated Raman scattering for highly sensitive low-frequency Raman spectroscopy Reviewed International journal

    Walker Peterson, Kotaro Hiramatsu, Keisuke Goda

    OPTICS LETTERS   44 ( 21 )   5282 - 5285   2019.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1364/OL.44.005282

  • A practical guide to intelligent image-activated cell sorting (vol 14, pg 2370, 2019) Reviewed International journal

    Akihiro Isozaki, Hideharu Mikami, Kotaro Hiramatsu, Shinya Sakuma, Yusuke Kasai, Takanori Iino, Takashi Yamano, Atsushi Yasumoto, Yusuke Oguchi, Nobutake Suzuki, Yoshitaka Shirasaki, Taichiro Endo, Takuro Ito, Kei Hiraki, Makoto Yamada, Satoshi Matsusaka, Takeshi Hayakawa, Hideya Fukuzawa, Yutaka Yatomi, Fumihito Arai, Dino Di Carlo, Atsuhiro Nakagawa, Yu Hoshino, Yoichiroh Hosokawa, Sotaro Uemura, Takeaki Sugimura, Yasuyuki Ozeki, Nao Nitta, Keisuke Goda

    NATURE PROTOCOLS   14 ( 11 )   3273 - 3273   2019.11

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    Language：English  

    DOI： 10.1038/s41596-019-0252-5

  • A practical guide to intelligent image-activated cell sorting Reviewed International journal

    Akihiro Isozaki, Hideharu Mikami, Kotaro Hiramatsu, Shinya Sakuma, Yusuke Kasai, Takanori Iino, Takashi Yamano, Atsushi Yasumoto, Yusuke Oguchi, Nobutake Suzuki, Yoshitaka Shirasaki, Taichiro Endo, Takuro Ito, Kei Hiraki, Makoto Yamada, Satoshi Matsusaka, Takeshi Hayakawa, Hideya Fukuzawa, Yutaka Yatomi, Fumihito Arai, Dino Di Carlo, Atsuhiro Nakagawa, Yu Hoshino, Yoichiroh Hosokawa, Sotaro Uemura, Takeaki Sugimura, Yasuyuki Ozeki, Nao Nitta, Keisuke Goda

    NATURE PROTOCOLS   14 ( 8 )   2370 - 2415   2019.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41596-019-0183-1

  • High-speed broadband Fourier-transform coherent anti-stokes Raman scattering spectral microscopy Reviewed International journal

    Ryo Kinegawa, Kotaro Hiramatsu, Kazuki Hashimoto, Venkata Ramaiah Badarla, Takuro Ideguchi, Keisuke Goda

    JOURNAL OF RAMAN SPECTROSCOPY   50 ( 8 )   1141 - 1146   2019.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/jrs.5630

  • High-throughput label-free molecular fingerprinting flow cytometry Reviewed International journal

    Kotaro Hiramatsu, Takuro Ideguchi, Yusuke Yonamine, SangWook Lee, Yizhi Luo, Kazuki Hashimoto, Takuro Ito, Misa Hase, Jee-Woong Park, Yusuke Kasai, Shinya Sakuma, Takeshi Hayakawa, Fumihito Arai, Yu Hoshino, Keisuke Goda

    SCIENCE ADVANCES   5 ( 1 )   eaau0241   2019.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1126/sciadv.aau0241

  • 超高速キラル分光法 Invited Reviewed

    平松光太郎

    分光研究   67 ( 4 )   144 - 153   2018.10

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  • Intelligent Image-Activated Cell Sorting Reviewed International journal

    Nao Nitta, Takeaki Sugimura, Akihiro Isozaki, Hideharu Mikami, Kei Hiraki, Shinya Sakuma, Takanori Iino, Fumihito Arai, Taichiro Endo, Yasuhiro Fujiwaki, Hideya Fukuzawa, Misa Hase, Takeshi Hayakawa, Kotaro Hiramatsu, Yu Hoshino, Mary Inaba, Takuro Ito, Hiroshi Karakawa, Yusuke Kasai, Kenichi Koizumi, SangWook Lee, Cheng Lei, Ming Li, Takanori Maeno, Satoshi Matsusaka, Daichi Murakami, Atsuhiro Nakagawa, Yusuke Oguchi, Minoru Oikawa, Tadataka Ota, Kiyotaka Shiba, Hirofumi Shintaku, Yoshitaka Shirasaki, Kanako Suga, Yuta Suzuki, Nobutake Suzuki, Yo Tanaka, Hiroshi Tezuka, Chihana Toyokawa, Yaxiaer Yalikun, Makoto Yamada, Mai Yamagishi, Takashi Yamano, Atsushi Yasumoto, Yutaka Yatomi, Masayuki Yazawa, Dino Di Carlo, Yoichiroh Hosokawa, Sotaro Uemura, Yasuyuki Ozeki, Keisuke Goda

    CELL   175 ( 1 )   266 - +   2018.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.cell.2018.08.028

  • Microfluidic single-particle chemical analyzer with dual-comb coherent Raman spectroscopy Reviewed International journal

    Takuro Ideguchi, Tasuku Nakamura, Shigekazu Takizawa, Miu Tamamitsu, Sangwook Lee, Kotaro Hiramatsu, Venkata Ramaiah-Badarla, Jee-woong Park, Yusuke Kasai, Takeshi Hayakawa, Shinya Sakuma, Fumihito Arai, Keisuke Goda

    OPTICS LETTERS   43 ( 16 )   4057 - 4060   2018.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1364/OL.43.004057

  • Development of a Hyper-Raman Microspectroscopic System Using a Wavelength-tunable Laser Source Reviewed

    Yoshiharu Yamada, Naoki Fukutake, Kotaro Hiramatsu, Hideaki Kano

    CHEMISTRY LETTERS   47 ( 5 )   660 - 663   2018.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1246/cl.180077

  • Rapid-scan Fourier-transform coherent anti-Stokes Raman scattering spectroscopy with heterodyne detection Reviewed International journal

    Kotaro Hiramatsu, Yizhi Luo, Takuro Ideguchi, Keisuke Goda

    OPTICS LETTERS   42 ( 21 )   4335 - 4338   2017.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1364/OL.42.004335

  • Raman optical activity spectroscopy by visible-excited coherent anti-Stokes Raman scattering Reviewed International journal

    Kotaro Hiramatsu, Philippe Leproux, Vincent Couderc, Takashi Nagata, Hideaki Kano

    OPTICS LETTERS   40 ( 17 )   4170 - 4173   2015.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1364/OL.40.004170

  • Communication: Broadband and ultrasensitive femtosecond time-resolved circular dichroism spectroscopy Reviewed International journal

    Kotaro Hiramatsu, Takashi Nagata

    JOURNAL OF CHEMICAL PHYSICS   143 ( 12 )   121102 - 121102   2015.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1063/1.4932229

  • Raman optical activity by coherent anti-Stokes Raman scattering spectral interferometry Reviewed International journal

    Kotaro Hiramatsu, Hideaki Kano, Takashi Nagata

    OPTICS EXPRESS   21 ( 11 )   13515 - 13521   2013.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1364/OE.21.013515

  • Observation of Raman Optical Activity by Heterodyne-Detected Polarization-Resolved Coherent Anti-Stokes Raman Scattering Reviewed International journal

    Kotaro Hiramatsu, Masanari Okuno, Hideaki Kano, Philippe Leproux, Vincent Couderc, Hiro-o Hamaguchi

    PHYSICAL REVIEW LETTERS   109 ( 8 )   083901 - 083901   2012.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1103/PhysRevLett.109.083901

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Presentations

  • Time-domain Raman spectroscopy for large-scale cell screening Invited

    Kotaro Hiramatsu

    The 12th International Conference on Advanced Vibrational Spectroscopy  2023.8 

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    Event date： 2023.8 - 2023.9

    Language：English  

    Country：Other  

    Time-domain Raman spectroscopy for large-scale cell screening

  • Time-domain Raman spectroscopy for large-scale cell screening Invited

    Kotaro Hiramatsu

    The 12th International Conference on Advanced Vibrational Spectroscopy  2023.8 

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    Event date： 2023.8 - 2023.9

    Language：English  

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  • Raman-fingerprint-activated cell sorting Invited

    Kotaro Hiramatsu

    SciX2023  2023.8 

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    Event date： 2023.8

    Language：English  

    Country：Other  

    Raman-fingerprint-activated cell sorting

  • Raman-fingerprint-activated cell sorting Invited

    Kotaro Hiramatsu

    SciX2023  2023.8 

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    Event date： 2023.8

    Language：English  

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  • Fourier-transform coherent anti-Stokes Raman scattering (FT-CARS) for biological research Invited

    Kotaro Hiramatsu

    Biomedical Raman Imaging  2023.6 

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    Event date： 2023.6

    Language：English  

    Country：Other  

    Fourier-transform coherent anti-Stokes Raman scattering (FT-CARS) for biological research

  • Fourier-transform coherent anti-Stokes Raman scattering (FT-CARS) for biological research Invited

    Kotaro Hiramatsu

    Biomedical Raman Imaging  2023.6 

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    Event date： 2023.6

    Language：English  

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  • Broadband fluorescence-encoded vibrational imaging

    Phillip McCann, Kotaro Hiramatsu, Keisuke Goda

    Advanced Chemical Microscopy for Life Science and Translational Medicine 2023, SPIE Photonics West  2023.1 

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    Event date： 2023.1 - 2023.2

    Language：English  

    Country：Other  

    Broadband fluorescence-encoded vibrational imaging

  • Broadband fluorescence-encoded vibrational imaging

    Phillip McCann, Kotaro Hiramatsu, Keisuke Goda

    Advanced Chemical Microscopy for Life Science and Translational Medicine 2023, SPIE Photonics West  2023.1 

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    Event date： 2023.1 - 2023.2

    Language：English   Presentation type：Oral presentation (general)  

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  • High-speed FT-CARS spectroscopy for high-throughput phenotyping Invited

    Kotaro Hiramatsu

    Advanced Chemical Microscopy for Life Science and Translational Medicine 2023, SPIE Photonics West  2023.1 

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    Event date： 2023.1 - 2023.2

    Language：English  

    Country：Other  

    High-speed FT-CARS spectroscopy for high-throughput phenotyping

  • High-speed FT-CARS spectroscopy for high-throughput phenotyping Invited

    Kotaro Hiramatsu

    Advanced Chemical Microscopy for Life Science and Translational Medicine 2023, SPIE Photonics West  2023.1 

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    Event date： 2023.1 - 2023.2

    Language：English   Presentation type：Oral presentation (invited, special)  

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  • 無標識指向性進化に向けたラマン活性細胞選抜法の開発

    中尾 龍二, 平松 光太郎, 合田 圭介

    レーザ顕微鏡研究会第47回講演会・シンポジウム  2022.11 

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    Event date： 2022.11

    Language：Others  

    Country：Other  

  • 蛍光エンコーディングによる高感度時間領域ラマン分光法

    田村 徹, McCann Phillip, 平松 光太郎, 合田 圭介

    第16回分子科学討論会2022 横浜  2022.9 

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    Event date： 2022.9

    Language：Japanese  

    Country：Other  

  • Fluorescence-Encoded Time-Domain Coherent Raman Spectroscopy

    Phillip McCann, Kotaro Hiramatsu, Keisuke Goda

    International conference on Raman spectroscopy 2022  2022.8 

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    Event date： 2022.8

    Language：English  

    Country：Other  

    Fluorescence-Encoded Time-Domain Coherent Raman Spectroscopy

  • Super-multiplex flow cytometry by cyanine-based Raman tags

    Ryo Nishiyama, Kotaro Hiramatsu, Kosuke Dodo, Shintaro Kawamura, Mikiko Sodeoka, Keisuke Goda

    International conference on Raman spectroscopy 2022  2022.8 

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    Event date： 2022.8

    Language：English  

    Country：Other  

    Super-multiplex flow cytometry by cyanine-based Raman tags

  • Label-free characterization of rare-cell populations by high-throughput Raman flow cytometry

    Kotaro Hiramatsu, Matt Lindley, Koji Yamada, Kengo Suzuki, Keisuke Goda

    International conference on Raman spectroscopy 2022  2022.8 

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    Event date： 2022.8

    Language：English  

    Country：Other  

    Label-free characterization of rare-cell populations by high-throughput Raman flow cytometry

  • Gold nanomesh for wearable SERS

    Kotaro Hiramatsu, Limei Liu, Pablo Martinez Pancorbo, Ting-Hui Xiao, Saya Noguchi, Machiko Marumi, Julia Gala de Pablo, Siddhant Karhadkar, Hiroki Segawa, Yasutaka Kitahama, Tamitake Itoh, Junle Qu, Kuniharu Takei, Keisuke Goda

    International conference on Raman spectroscopy 2022  2022.8 

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    Event date： 2022.8

    Language：English  

    Country：Other  

    Gold nanomesh for wearable SERS

  • Gold nanomesh for wearable SERS

    Kotaro Hiramatsu, Limei Liu, Pablo Martinez Pancorbo, Ting-Hui Xiao, Saya Noguchi, Machiko Marumi, Julia Gala de Pablo, Siddhant Karhadkar, Hiroki Segawa, Yasutaka Kitahama, Tamitake Itoh, Junle Qu, Kuniharu Takei, Keisuke Goda

    International conference on Raman spectroscopy 2022  2022.8 

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    Event date： 2022.8

    Language：English  

    Country：Other  

    Gold nanomesh for wearable SERS

  • Super-multiplex flow cytometry by cyanine-based Raman tags

    Ryo Nishiyama, Kotaro Hiramatsu, Kosuke Dodo, Shintaro Kawamura, Mikiko Sodeoka, Keisuke Goda

    International conference on Raman spectroscopy 2022  2022.8 

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    Event date： 2022.8

    Language：English   Presentation type：Oral presentation (general)  

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  • Fluorescence-Encoded Time-Domain Coherent Raman Spectroscopy

    Phillip McCann, Kotaro Hiramatsu, Keisuke Goda

    International conference on Raman spectroscopy 2022  2022.8 

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    Event date： 2022.8

    Language：English   Presentation type：Oral presentation (general)  

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  • Gold nanomesh for wearable SERS

    Kotaro Hiramatsu, Limei Liu, Pablo Martinez Pancorbo, Ting-Hui Xiao, Saya Noguchi, Machiko Marumi, Julia Gala de Pablo, Siddhant Karhadkar, Hiroki Segawa, Yasutaka Kitahama, Tamitake Itoh, Junle Qu, Kuniharu Takei, Keisuke Goda

    International conference on Raman spectroscopy 2022  2022.8 

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    Event date： 2022.8

    Language：English   Presentation type：Oral presentation (general)  

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  • Gold nanomesh for wearable SERS

    Kotaro Hiramatsu, Limei Liu, Pablo Martinez Pancorbo, Ting-Hui Xiao, Saya Noguchi, Machiko Marumi, Julia Gala de Pablo, Siddhant Karhadkar, Hiroki Segawa, Yasutaka Kitahama, Tamitake Itoh, Junle Qu, Kuniharu Takei, Keisuke Goda

    International conference on Raman spectroscopy 2022  2022.8 

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    Event date： 2022.8

    Language：English   Presentation type：Oral presentation (general)  

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  • Label-free characterization of rare-cell populations by high-throughput Raman flow cytometry

    Kotaro Hiramatsu, Matt Lindley, Koji Yamada, Kengo Suzuki, Keisuke Goda

    International conference on Raman spectroscopy 2022  2022.8 

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    Event date： 2022.8

    Language：English   Presentation type：Oral presentation (general)  

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  • Unconventional modalities in flow cytometry FLIM, Raman, SHG, etc. Invited

    Kotaro Hiramatsu

    The Complexity of Dynamics and Kinetics from Single Molecules to Cells, Telluride Science and Innovation Center  2022.6 

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    Event date： 2022.6

    Language：English  

    Country：Other  

    Unconventional modalities in flow cytometry FLIM, Raman, SHG, etc.

  • CARS-ROAによる分子キラリティーの観測

    平松光太郎, 奥野将成, 加納英明, 永田敬, 濵口宏夫

    第6回分子科学討論会  2012.9 

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  • CARS-ROAのショットノイズ限界測定

    平松光太郎, 奥野将成, 加納英明, 永田敬, 濵口宏夫

    日本分光学会年次講演会  2012.11 

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  • Raman optical activity measured by CARS spectral interferometry International conference

    Kotaro Hiramatsu, Hideaki Kano, Takashi Nagata

    European Conference on Nonlinear Optical Spectroscopy (ECONOS) 2013  2013.4 

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    Raman optical activity measured by CARS spectral interferometry

  • Raman optical activity measured by nonlinear Raman scattering International conference

    Kotaro Hiramatsu, Hideaki Kano, Takashi Nagata

    International Conference on Chiroptical Spectroscopy 2013 (CD2013)  2013.6 

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    Raman optical activity measured by nonlinear Raman scattering

  • Raman optical activity measured by coherent anti-Stokes Raman scattering International conference

    Kotaro Hiramatsu, Hideaki Kano, Takashi Nagata

    Seventh International Conference on Advanced Vibrational Spectroscopy (ICAVS7)  2013.8 

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    Raman optical activity measured by coherent anti-Stokes Raman scattering

  • コヒーレントラマン散乱を用いたラマン光学活性分光法の開発 Invited

    平松光太郎

    第9回 若手研究者たちによる先端的レーザー分光シンポジウム  2013.12 

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  • コヒーレントラマン分光法でみる分子のキラリティー Invited

    平松光太郎

    量子エレクトロニクス研究会「バイオ・メディカルフォトニクス：基礎と応用の最前線」  2013.12 

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  • Coherent Raman optical activity spectroscopy Invited International conference

    Kotaro Hiramatsu

    Spectroscopic studies on molecular chirality  2013.12 

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    Coherent Raman optical activity spectroscopy

  • ヘテロダイン検出法によるアキラルバックグラウンドフリーな光活性測定法の開発 Invited

    平松光太郎

    第５回キラルサイエンス＆テクノロジーシンポジウム  2014.2 

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  • 広帯域・高感度フェムト秒時間分解円二色性分光法の開発

    平松光太郎, 永田 敬

    日本化学会第95春季年会  2015.3 

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  • 分光干渉法を用いた広帯域高感度フェムト秒 時間分解円二色性分光法の開発

    平松光太郎, 永田 敬

    日本分光学会平成27年度年次講演会  2015.6 

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  • Visible-excited CARS-ROA spectroscopy

    Kotaro Hiramatsu, Takashi Nagata, Hideaki Kano

    15th International Conference on Chiroptical Spectroscopy  2015.8 

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    Visible-excited CARS-ROA spectroscopy

  • Broadband and ultrasensitive femtosecond time-resolved circular dichroism spectroscopy using spectral interferometry

    Kotaro Hiramatsu, Takashi Nagata

    15th International Conference on Chiroptical Spectroscopy  2015.8 

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    Broadband and ultrasensitive femtosecond time-resolved circular dichroism spectroscopy using spectral interferometry

  • 超高速円二色性分光法による生体分子の励起状態ダイナミクス観測

    平松光太郎, 永田 敬

    第9回分子科学討論会  2015.9 

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  • フェムト秒CD分光法による超高速キラル反転の実時間観測 Invited

    平松光太郎

    「柔らかな分子系」ワークショップ 構造変化で操る分子の機能  2017.1 

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  • Rapid-Scan Fourier-Transform CARS Spectroscopy with Heterodyne Detection

    Yizhi Luo, Kotaro Hiramatsu, Takuro Ideguchi, Keisuke Goda

    2017.3 

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    Rapid-Scan Fourier-Transform CARS Spectroscopy with Heterodyne Detection

  • 超高速キラル分光法の開発と応用 Invited

    平松 光太郎

    第7回光科学異分野横断萌芽研究会  2017.8 

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    Country：Other  

  • 高速フーリエ変換CARS顕微鏡

    木下川 涼, 平松 光太郎, 井手口 拓郎, 合田 圭介

    第78回応用物理学会秋季学術講演会  2017.9 

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    Country：Other  

  • コヒーレントラマン散乱を用いたROA分光法

    平松光太郎

    日本分光学会赤外ラマン部会, キラル振動分光法の基礎と最新技術  2017.11 

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    Country：Other  

  • High-speed broadband Fourier-transform CARS microscopy

    Kotaro Hiramatsu, Ryo Kinegawa, Kazuki Hashimoto, Venkata Ramaiah Badarla, Takuro Ideguchi, Keisuke Goda

    SPIE Photonics West, High-Speed Biomedical Imaging and Spectroscopy III: Toward Big Data Instrumentation and Management  2018.1 

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    High-speed broadband Fourier-transform CARS microscopy

  • Heterodyne-detected rapid-scan Fourier-transform CARS spectroscopy

    Kotaro Hiramatsu, Yizhi Luo, Takuro Ideguchi, Keisuke Goda

    SPIE Photonics West, Biomedical Vibrational Spectroscopy 2018: Advances in Research and Industry  2018.1 

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    Country：Other  

    Heterodyne-detected rapid-scan Fourier-transform CARS spectroscopy

  • High-speed Fourier-transform coherent anti-Stokes Raman scattering spectroscopy with heterodyne detection

    Kotaro Hiramatsu, Yizhi Luo, Takuro Ideguchi, Keisuke Goda

    2018.3 

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    Country：Other  

    High-speed Fourier-transform coherent anti-Stokes Raman scattering spectroscopy with heterodyne detection

  • Simultaneous FT-CARS and fluorescence spectroscopy at 24,000 spectra per second

    Matthew Lindley, Hayate Nomoto, Kotaro Hiramatsu, Keisuke Goda

    2018.5 

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    Simultaneous FT-CARS and fluorescence spectroscopy at 24,000 spectra per second

  • 時間領域Raman分光法の生命科学研究への応用

    平松 光太郎, 合田 圭介

    第8回光科学異分野横断萌芽研究会  2018.8 

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  • デュアルコムコヒーレントラマン分光によるマイクロ流体１粒子分析

    滝沢 繁和, 中村 將, 井手口 拓郎, 玉光 未侑, 李 相旭, 平松 光太郎, Ramaiah Venkata, 朴 智雄, 笠井 宥佑, 早川 健, 佐久間 臣耶, 新井 史人, 合田 圭介

    第79回応用物理学会秋季学術講演会  2018.9 

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    Country：Other  

  • High-speed simultaneous Raman-fluorescence spectrometer

    Matthew Lindley, Hayate Nomoto, Kotaro Hiramatsu, Keisuke Goda

    2018.9 

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    High-speed simultaneous Raman-fluorescence spectrometer

  • High-throughput broadband CARS flow cytometry at >2,000 cells/s International conference

    Kotaro Hiramatsu, Takuro Ideguchi, Yusuke Yonamine, SangWook Lee, Yizhi Luo, Kazuki Hashimoto, Takuro Ito, Misa Hase, Jee-Woong Park, Yusuke Kasai, Shinya Sakuma, Takeshi Hayakawa, Fumihito Arai, Yu Hoshino, Keisuke Goda

    SPIE Photonics West, High-Speed Biomedical Imaging and Spectroscopy IV: Toward Big Data Instrumentation and Management, Photonics West  2019.2 

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    Language：English  

    Country：United States  

    High-throughput broadband CARS flow cytometry at >2,000 cells/s

  • High-speed simultaneous CARS and fluorescence spectroscopies International conference

    Matthew Lindley, Hayate Nomoto, Kotaro Hiramatsu, Keisuke Goda

    SPIE Photonics West, High-Speed Biomedical Imaging and Spectroscopy IV: Toward Big Data Instrumentation and Management, Photonics West  2019.2 

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    Country：United States  

    High-speed simultaneous CARS and fluorescence spectroscopies

  • コヒーレントラマン散乱を用いたROA分光法 Invited

    平松 光太郎

    第23回HiSOR研究会 ~分子キラリティの計測・理論技術の革新から迫る生命機能研究の新展開~  2019.3 

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    Language：Japanese  

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  • Intelligent Image-Activated Cell Sorting: Principles and Applications

    2019.3 

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    Country：Japan  

    Intelligent Image-Activated Cell Sorting: Principles and Applications

  • High-throughput broadband Raman flow cytometry

    2019.3 

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    Country：Japan  

    High-throughput broadband Raman flow cytometry

  • Label-free molecularly specific flow cytometry and beyond International conference

    Kotaro Hiramatsu, Yusuke Yonamine, Takuro Ito, Yu Hoshino, Keisuke Goda

    34th Congress of the International Society for Advancement of Cytometry  2019.6 

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    Language：English  

    Country：Canada  

    Label-free molecularly specific flow cytometry and beyond

  • High-throughput Raman spectroscopic flow cytometry" Invited International conference

    Kotaro Hiramatsu, Keisuke Goda

    The Australia and New Zealand Nano and Microfluidics 2019  2019.7 

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    Language：English  

    Country：Australia  

    High-throughput Raman spectroscopic flow cytometry"

  • Coherent Raman spectroscopic flow cytometry for large-scale single cell analysis International conference

    Kotaro Hiramatsu, Yusuke Yonamine, Takuro Ito, Yu Hoshino, Keisuke Goda

    International conference on vibrational spectroscopy  2019.7 

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    Coherent Raman spectroscopic flow cytometry for large-scale single cell analysis

  • 高速ラマン分光フローサイトメトリー

    平松 光太郎, 合田圭介

    第9回光科学異分野横断萌芽研究会  2019.8 

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    Country：Japan  

  • 振動分光フローサイトメトリーによる大規模無標識1細胞解析

    平松 光太郎, Matthew Lindley, 山田 康嗣, 鈴木 健吾, 合田 圭介

    第80回応用物理学会秋季学術講演会  2019.9 

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  • 圧縮センシングを用いた時間領域コヒーレントラマン分光

    滝沢 繁和, 平松 光太郎, 合田 圭介

    第80回応用物理学会秋季学術講演会  2019.9 

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  • Simultaneous Raman-Fluorescence Flow Cytometry

    Matthew Lindley, Kotaro Hiramatsu, Fukashi Shibata, Tsuyoshi Takeshita, Shigeyuki Kawano, Keisuke Goda

    2019.9 

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    Country：Japan  

    Simultaneous Raman-Fluorescence Flow Cytometry

  • 高速ラマン分光法による大規模一細胞解析 Invited

    平松 光太郎

    第１７回医用分光学研究会  2019.11 

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  • Large-scale single-cell analysis by ultra-rapid time-domain Raman spectroscopy Invited International conference

    Kotaro Hiramatsu, Keisuke Goda

    The 12th International Photonics and OptoElectronics Meetings  2019.11 

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    Language：English  

    Country：China  

    Large-scale single-cell analysis by ultra-rapid time-domain Raman spectroscopy

  • High-throughput Raman flow cytometry Invited International conference

    Kotaro Hiramatsu, Keisuke Goda

    SelectBio 2019 - Microfluidics & Organ-on-a-Chip Asia 2019  2019.11 

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    Country：Japan  

    High-throughput Raman flow cytometry

  • High-throughput Broadband Vibrational Flow Cytometry International conference

    Kotaro Hiramatsu, Keisuke Goda

    Biomedical Raman Imaging  2019.11 

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    High-throughput Broadband Vibrational Flow Cytometry

  • 多元的分光計測による大規模一細胞解析 Invited

    平松 光太郎

    分光学会生細胞分光部会シンポジウム  2019.12 

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    Country：Japan  

  • 高スループット振動分光フローサイトメトリー Invited

    平松 光太郎, 合田 圭介

    レーザー学会 学術講演会 第40回年次大会  2020.1 

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    Country：Japan  

  • Highly sensitive low-frequency Raman spectroscopy enabled by Sagnac-enhanced impulsive stimulated Raman scattering International conference

    Walker Peterson, Kotaro Hiramatsu, Keisuke Goda

    SPIE Photonics West, Label-free Biomedical Imaging and Sensing (LBIS) 2020  2020.2 

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    Highly sensitive low-frequency Raman spectroscopy enabled by Sagnac-enhanced impulsive stimulated Raman scattering

  • High-throughput vibrational flow cytometry Invited International conference

    Kotaro Hiramatsu, Keisuke Goda

    Advanced Chemical Microscopy for Life Science and Translational Medicine, Photonics West  2020.2 

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    Country：United States  

    High-throughput vibrational flow cytometry

  • High-throughput multimodal Raman-fluorescence flow cytometry International conference

    Matthew Lindley, Kotaro Hiramatsu, Fukashi Shibata, Tsuyoshi Takeshita, Shigeyuki Kawano, Keisuke Goda

    SPIE Photonics West, High-Speed Biomedical Imaging and Spectroscopy V  2020.2 

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    High-throughput multimodal Raman-fluorescence flow cytometry

  • 繰り返し周波数変調による高速コヒーレントラマン分光法

    亀山 理紗子, 平松 光太郎, 合田 圭介

    分子科学会オンライン討論会  2020.9 

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  • ラベルフリー代謝工学に向けたラマンフローサイトメーターの開発

    中尾 龍二, 平松 光太郎, 橋爪里奈, 那須 雄介, Robert E. Campbell, 合田 圭介

    量子生命科学会 第二回大会  2020.12 

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  • 擬デュアルコム光源による高速コヒーレントラマン分光法

    亀山 理紗, 滝沢 繁和, 平松 光太郎, 合田 圭介

    第68回応用物理学会春季学術講演会  2021.3 

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    Country：Japan  

  • High-speed low-frequency vibrational spectroscopy using a Sagnac interferometer

    Jorgen Walker Peterson, Matt Lindley, Julia Gala de Pablo, Kotaro Hiramatsu, Keisuke Goda

    2021.3 

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    Country：Japan  

    High-speed low-frequency vibrational spectroscopy using a Sagnac interferometer

  • Fluorescence-encoded time-domain coherent Raman spectroscopy through single-photon counting International conference

    Phillip Charles McCann, Kotaro Hiramatsu, Keisuke Goda

    Single Molecule Spectroscopy and Superresolution Imaging XIV, Photonics West  2021.3 

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    Fluorescence-encoded time-domain coherent Raman spectroscopy through single-photon counting

  • Fast, sensitive dual-comb CARS spectroscopy with a quasi-dual-comb laser International conference

    Risako Kameyama, Sigekazu Takizawa, Kotaro Hiramatsu, Keisuke Goda

    High-Speed Biomedical Imaging and Spectroscopy VI, Photonics West  2021.3 

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    Fast, sensitive dual-comb CARS spectroscopy with a quasi-dual-comb laser

  • 四波混合・第二次高調波イメージングフローサイトメトリー

    木下川 涼, ガラ デ パブロ ジュリア, 王 弋, 平松 光太郎, 合田 圭介

    第82回応用物理学会秋季学術講演会  2021.9 

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  • 圧縮フーリエ分光イメージング：シミュレーションによる検討

    滝沢繁和, 平松 光太郎, 合田圭介

    2021年度日本分光学会年次講演会  2021.10 

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  • プローブ光の位相遅延と周波数シフトの同期検出による低波数領域と指紋領域の超高速インパルシブ・ラマン分光法

    ピーターソン ウォーカー, ガラデパブロー, ジュリア, リンドリー マット, 平松 光太郎, 合田 圭介

    2021年度日本分光学会年次講演会  2021.10 

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  • プラズモンフリーSERSのための多孔質カーボンナノワイヤー

    平松 光太郎, 陳南, 肖廷輝, 罗桢埸, 北濱康孝, 岸本直樹, 伊藤民武, 程振洲, 合田圭介, 合田圭介

    2021年度日本分光学会年次講演会  2021.10 

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  • シリコンナノディスクアレイを用いたキラル場増強ラマン光学活性

    平松 光太郎, 肖廷, 罗桢埸, 磯崎瑛宏, 伊藤民武, 程振洲, 野村政宏, 岩本敏, 合田圭介

    2021年度日本分光学会年次講演会  2021.10 

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  • Raman spectroscopy and imaging of single cells in flow Invited

    Kotaro Hiramatsu, Keisuke Goda

    SciX2021  2021.10 

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    Raman spectroscopy and imaging of single cells in flow

  • Fluorescence-Encoded Time-Domain Coherent Raman Spectroscopy

    Phillip McCann, Kotaro Hiramatsu, Keisuke Goda

    2021.10 

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    Fluorescence-Encoded Time-Domain Coherent Raman Spectroscopy

  • 高スループットラマンフローサイトメーターによる多細胞分析 Invited

    平松 光太郎

    レーザ顕微鏡研究会第46回講演会  2021.11 

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  • 蛍光エンコーディングによる超高感度ラマン分光計測 Invited

    平松 光太郎

    レーザー学会学術講演会第42回年次大会  2022.1 

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  • THz-fingerprint coherent Raman spectroscopy at over 20,000 spectra/sec

    Jorgen Walker Peterson, Matt Lindley, Julia Gala de Pablo, Kotaro Hiramatsu, Keisuke Goda

    High-Speed Biomedical Imaging and Spectroscopy VII, SPIE Photonics West 2022  2022.1 

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    THz-fingerprint coherent Raman spectroscopy at over 20,000 spectra/sec

  • Raman image-activated cell sorting and beyond Invited

    Kotaro Hiramatsu, Keisuke Goda

    Advanced Chemical Microscopy for Life Science and Translational Medicine 2022  2022.1 

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    Raman image-activated cell sorting and beyond

  • Raman flow cytometry on a chip Invited

    Kotaro Hiramatsu

    High-Speed Biomedical Imaging and Spectroscopy VII, SPIE Photonics West  2022.1 

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    Raman flow cytometry on a chip

  • Porous carbon nanowires for plasmon-free SERS

    Tinghui Xiao, Nan Chen, Zhengyi Luo, Yasutaka Kitahama, Kotaro Hiramatsu, Naoki Kishimoto, Tamitake Itoh, Zhenzhou Cheng, Keisuke Goda

    Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry, SPIE Photonics West 2022  2022.1 

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    Porous carbon nanowires for plasmon-free SERS

  • High-speed Fourier-transform spectroscopy by non-mechanical cavity modulation Invited

    Kotaro Hiramatsu

    Smart Photonic and Optoelectronic Integrated Circuits 2022, SPIE Photonics Wes  2022.1 

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    High-speed Fourier-transform spectroscopy by non-mechanical cavity modulation

  • Chiral-field-enhanced Raman optical activity by a silicon nanodisk array

    Tinghui Xiao, Zhengyi Luo, Kotaro Hiramatsu, Akihiro Isozaki, Tamitake Itoh, Zhenzhou Cheng, Masahiro Nomura, Satoshi Iwamoto, Keisuke Goda

    Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry, SPIE Photonics West 2022  2022.1 

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    Chiral-field-enhanced Raman optical activity by a silicon nanodisk array

  • 切って、置いて、測るだけ：金ナノメッシュによる超簡便SERS

    北濱 康孝, 合田 圭介, 丸見 真智子, Pancorbo Pablo, 瀬川 尋貴, Xiao Ting-Hui, 平松 光太郎, Yang William

    第70回応用物理学会春季学術講演会  2022.3 

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  • Ultra-broadband time-domain Raman spectroscopy using synchronized mode-locked lasers Invited

    Kotaro Hiramatsu, Keisuke Goda

    Biomedical Spectroscopy, Microscopy, and Imaging II, Photonics Europe  2022.4 

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    Ultra-broadband time-domain Raman spectroscopy using synchronized mode-locked lasers

  • 環状分子を用いた超高輝度ラマンプローブの開発

    古屋 圭惟, 西山 諒, McCann Phillip, Kacenauskaite Laura, Laursen Bo, H. Flood Ama, 平松 光太郎, 合田 圭介

    第70回応用物理学会春季学術講演会  2023.3 

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  • ラマンタグを用いた超多色フローサイトメトリー

    西山 諒, 平松 光太郎, 河村 伸太郎, 闐闐 孝介, 古屋 圭惟, ミン ウェイ, 袖岡 幹子, 合田 圭介

    第70回応用物理学会春季学術講演会  2023.3 

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  • 無標識分光計測に基づく細胞分取 Invited

    平松 光太郎

    第71回応用物理学会春季学術講演会  2024.3 

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  • 時間領域ラマン分光法の深化と生物応用 Invited

    平松 光太郎

    日本光学会年次学術講演会  2023.11 

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  • 偏光分解ヘテロダインCARSによるラマン光学活性の観測

    平松光太郎, 奥野将成, 加納英明, 濵口宏夫

    日本化学会第92春季年会  2012.3 

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  • Chiral-field-enhanced Raman optical activity by a silicon nanodisk array

    Tinghui Xiao, Zhengyi Luo, Kotaro Hiramatsu, Akihiro Isozaki, Tamitake Itoh, Zhenzhou Cheng, Masahiro Nomura, Satoshi Iwamoto, Keisuke Goda

    Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry, SPIE Photonics West 2022  2022.1 

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    Language：English   Presentation type：Oral presentation (general)  

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  • Porous carbon nanowires for plasmon-free SERS

    Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry, SPIE Photonics West 2022  2022.1 

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  • Raman flow cytometry on a chip Invited

    Kotaro Hiramatsu

    High-Speed Biomedical Imaging and Spectroscopy VII, SPIE Photonics West  2022.1 

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  • Raman image-activated cell sorting and beyond Invited

    Kotaro Hiramatsu, Keisuke Goda

    Advanced Chemical Microscopy for Life Science and Translational Medicine 2022  2022.1 

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  • THz-fingerprint coherent Raman spectroscopy at over 20,000 spectra/sec

    Jorgen Walker Peterson, Matt Lindley, Julia Gala de Pablo, Kotaro Hiramatsu, Keisuke Goda

    High-Speed Biomedical Imaging and Spectroscopy VII, SPIE Photonics West 2022  2022.1 

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    Language：English   Presentation type：Oral presentation (general)  

    researchmap

  • Ultra-broadband time-domain Raman spectroscopy using synchronized mode-locked lasers Invited

    Kotaro Hiramatsu, Keisuke Goda

    Biomedical Spectroscopy, Microscopy, and Imaging II, Photonics Europe  2022.4 

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    Language：English   Presentation type：Oral presentation (invited, special)  

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MISC

  • ラマン分光フローサイトメトリ Reviewed

    西山 諒, 古屋 圭惟, 平松 光太郎, 合田 圭介

    生物物理   2024.4

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  • 圧縮センシングによる高速時間領域ハイパースペクトルイメージング Reviewed

    滝沢 繁和, 平松光太郎, 小野 峻佑, 合田 圭介

    光学   2023.10

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  • ラマンイメージング x 圧縮センシング Reviewed

    平松光太郎, 滝沢繁和, 小野峻佑, 合田圭介

    分光研究   2023.8

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  • 単一細胞レベルの大規模画像プロファイリングによるCOVID-19患者血液中の循環血小板凝集塊の解析—Analyzing circulating platelet aggregates in patients with COVID-19 by massive image-based single-cell profiling

    菅野 寛志, Yuqi ZHOU, 西川 真子, Ting-Hui XIAO, 鈴木 拓真, 伊林 侑真, Jeffrey HARMON, 滝沢 繁和, 平松 光太郎, 新田 尚, 亀山 理紗子, Walker PETERSON, 滝口 純, Mohammad SHIFAT-E-RABII, Yan ZHUANG, Xuwang YIN, Abu Hasnat Mohammad RUBAIYAT, Yunjie DENG, Hongqian ZHANG, 宮田 茂樹, Gustavo K. ROHDE, 岩崎 渉, 矢冨 裕, 合田 圭介

    化学とマイクロ・ナノシステム = Journal of the Society for Chemistry and Micro-Nano Systems : 化学とマイクロ・ナノシステム研究会誌   2022.3

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    Language：Japanese  

Industrial property rights

Patent   Number of applications: 0   Number of registrations: 0
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • THe Chemical Society of Japan

  • Japan Society for Molecular Science

  • The Spectroscopical Society of Japan

  • The Japan Society of Applied Physics

  • The Optical Society of Japan

  • American Chemical Society

  • SPIE - The international society of optics and photonics

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Committee Memberships

  • 日本光学会   光・光委員会   Domestic

    2023.4 - Present   

  • 日本分光学会   出版委員   Domestic

    2022.4 - Present   

Academic Activities

  • Screening of academic papers

    Role(s)： Peer review

    2023

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：7

  • Screening of academic papers

    Role(s)： Peer review

    2022

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：6

  • Screening of academic papers

    Role(s)： Peer review

    2022

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：8

  • 事務局長

    量子生命科学研究会第3回大会  （ オンライン ） 2021.9

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    Type：Competition, symposium, etc. 

    Number of participants：174

  • Screening of academic papers

    Role(s)： Peer review

    2020

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：17

  • Screening of academic papers

    Role(s)： Peer review

    2019

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：4

  • Screening of academic papers

    Role(s)： Peer review

    2019

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：6

  • Screening of academic papers

    Role(s)： Peer review

    2017

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：7

  • Screening of academic papers

    Role(s)： Peer review

    2016

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：4

  • Screening of academic papers

    Role(s)： Peer review

    2014

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：1

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Research Projects

  • 高速超解像イメージングのための空間―周波数圧縮顕微鏡の開発

    2024

    コニカミノルタ画像科学奨励賞

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    Authorship：Principal investigator  Grant type：On-campus funds, funds, etc.

  • コグニティブ分光プラットフォームの創生

    2022.4 - 2028.3

    科学技術振興機構 

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    Authorship：Principal investigator 

  • テラヘルツ領域の１分子振動分光イメージング

    2022.4 - 2026.3

    日本学術振興会 

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    Authorship：Principal investigator 

  • コグニティブ分光プラットフォームの創生

    2022 - 2028

    戦略的創造研究推進事業 (文部科学省)

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    Authorship：Principal investigator  Grant type：Contract research

  • テラヘルツ領域の１分子振動分光イメージング

    Grant number：22H02029  2022 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 蛍光エンコーディングによる１分子振動分光イメージング

    2022 - 2023

    光科学技術研究振興財団

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    Grant type：On-campus funds, funds, etc.

  • 蛍光エンコーディングによる超高感度ラマン分光

    Grant number：20K15227  2020 - 2021

    日本学術振興会  科学研究費助成事業  若手研究

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 任意のスペクトル次元を測定できるfunctional Raman分光法の開発

    2018 - 2021

    戦略的創造研究推進事業 (文部科学省)

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    Authorship：Principal investigator  Grant type：Contract research

  • 高性能ラマン・フローサイトメトリーを用いた無標識代謝解析によるスマートセル選抜技術の研究開発

    2018

    NEDO 植物等の生物を用いた高機能品生産技術の開発／ スマートセル関連技術の社会実装推進に向けて解決すべき新規課題の検討

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    Authorship：Coinvestigator(s)  Grant type：Contract research

  • ２光子コヒーレンストモグラフィー法の開発

    2018

    立石科学技術振興財団　研究助成(A)

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    Authorship：Principal investigator  Grant type：On-campus funds, funds, etc.

  • 光周波数コムを用いた磁気共鳴測定法の開発とバイオイメージングへの応用

    Grant number：17K19099  2017 - 2019

    日本学術振興会  科学研究費助成事業  挑戦的研究（萌芽）

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    Grant type：Scientific research funding

  • Optical NMR法の開発とそれによる細胞内分子の可視化

    2017

    公益財団法人宇部興産学術振興財団 第57回学術奨励賞

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    Authorship：Principal investigator  Grant type：On-campus funds, funds, etc.

  • 光周波数コムを用いたOptical NMR法の開発

    2017

    公益財団法人精密測定技術振興財団 研究助成

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    Authorship：Principal investigator  Grant type：On-campus funds, funds, etc.

  • コヒーレントラマン分光法による時間分解ラマン光学活性測定法の開発

    2013 - 2016

    日本学術振興会  特別研究員

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    Authorship：Principal investigator  Grant type：Joint research

  • コヒーレントラマン分光法による時間分解ラマン光学活性測定法の開発

    Grant number：13J01123  2013 - 2015

    日本学術振興会  科学研究費助成事業  特別研究員奨励費

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    Grant type：Scientific research funding

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Educational Activities

  • Our goal is to create new methodologies to capture natural phenomena, to carry out research that can create new value through such research, and to provide education that will foster human resources with the ability to do so. To this end, our educational activities focus on the following elements
    1. Deep understanding of basic physics and chemistry and the ability to apply them on one's own
    2. the ability to coarse-grained and model phenomena that cannot be fully explained by deduction from basic equations
    3. strong curiosity about natural phenomena
    4. matching curiosity with social needs
    While the amount of data obtained experimentally has dramatically increased due to improvements in the performance of measuring instruments and computers, and the estimation of phenomena by machine learning has become very powerful in basic science research, it is still difficult to extrapolate to phenomena that have not been measured before or to areas where data is scarce. In order to explore such new areas, we train researchers to define an area based on their curiosity, design measurements that can cover the area based on basic physics and chemistry, and then measure and model the area.

Class subject

  • 光生物物理化学（※コロイド化学）

    2024.10 - 2025.3   Second semester

  • 化学数学

    2024.4 - 2024.9   First semester

Other educational activity and Special note

  • 2024  Class Teacher 

  • 2024  Special Affairs 

  • 2023  Class Teacher 

Outline of Social Contribution and International Cooperation activities

  • Public lectures are held for the general public. Accepting trainees from abroad in the laboratory.

Social Activities

  • コヒーレントラマン分光法の基礎と生命科学応用

    （株）オプトロニクス  パシフィコ横浜  2024.5

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    Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Seminar, workshop

    コヒーレントラマンイメージングは，細胞内分子を無標識かつ高速に計測できるため，2010年頃から多くの注目を集めている．近年では市販のコヒーレントラマン顕微鏡も登場し，生命科学・医学研究において実用できるツールとなりつつある．一方，最近5年程度の先端研究としては，ラマンタグとの融合による超多色計測，蛍光エンコーディングによる高感度化，オミクス解析との融合，量子光学の応用による高感度化，フローサイトメトリーとの融合による大規模細胞解析などが挙げられ，更なる高感度化や新たな応用開拓が進められている．本講演では，コヒーレントラマン散乱の基礎を解説した後に，これら最近のトピックを紹介し，コヒーレントラマン分光法を用いた生命科学研究の今後を展望することを目指す．

  • 2023年ノーベル賞受賞研究解説会

    ピカリかがく  九大伊都 蔦屋書店  2023.11

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    Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Lecture

Acceptance of Foreign Researchers, etc.

  • University of Limoges

    Acceptance period： 2024.5 - 2024.8   （Period）：1 month or more

    Nationality：France

    Business entity：Other

Travel Abroad

  • 2014.10 - 2015.3

    Staying countory name 1：Japan   Staying institution name 1：サウサンプトン大学