FUJIWARA MANABI
Organization
Faculty of Science Department of Biology Associate Professor
School of Sciences Department of Biology（Concurrent）
Graduate School of Systems Life Sciences Department of Systems Life Sciences（Concurrent）
Title
Associate Professor
Contact information
Tel
0926422627
Profile
Molecular genetics of the adaptation system in the nematode, C. elegans to external and internal enviroments
External link
Degree
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Ph.D (Science)
Research History
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University of California, San Francisco: 1999.6-2002.9
Research Interests・Research Keywords
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Research theme：The analyses of the operation modules for integration and extraction of information in neural circuits
Keyword：C.elegans, neural circuit, olfaction, behavior, Calcium imaging, optogenetics, activity-dependent transcription
Research period： 2018.4 - 2023.3
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Research theme：Molecular genetics of behavioral changes due to sexual maturity in the nematode, C. elegans.
Keyword：C. elegans, gender dimorphism, gonad signal, behavior
Research period： 2006.4
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Research theme：線虫C.elegansの発生、行動、生体のホメオスタシスに感覚情報が果たす役割
Keyword：体のサイズ、脂肪量、感覚受容変異体、線虫C.elegans
Research period： 1999.6
Papers
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EGL-4/PKG regulates the role of an interneuron in a chemotaxis circuit of C. elegans through mediating integration of sensory signals Invited Reviewed International journal
#Takahiro Hino, #Shota Hirai, Takeshi Ishihara, Manabi Fujiwara
Genes to Cells 26 411 - 425 2021.6
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Gonadal Maturation Changes Chemotaxis Behavior and Neural Processing in the Olfactory Circuit of Caenorhabditis elegans. Reviewed International journal
Manabi Fujiwara, Itaru Aoyama, Takahiro Hino, Takayuki Teramoto, Takeshi Ishihara
Current Biology 26 ( 12 ) 1522 - 1531 2016.6
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The Importance of cGMP Signaling in Sensory Cilia for Body Size Regulation in Caenorhabditis elegans Reviewed International journal
Manabi Fujiwara, Takahiro Hino, Ryuta Miyamoto, Hitoshi Inada, Ikue Mori, Makoto Koga, Koji Miyahara, Yasumi Ohshima, Takeshi Ishihara
Genetics 201 1497 - 1510 2015.12
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A Novel zf-MYND Protein, CHB-3, Mediates Guanylyl Cyclase Localization to Sensory Cilia and Controls Body Size of Caenorhabditiselegans Reviewed International journal
Manabi Fujiwara1*, Takayuki Teramoto1, Takeshi Ishihara1, Yasumi Ohshima2, Steven L. McIntire
PLos Gentics 6 ( 11 ) 2010.12
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ADBP-1 Regulates an ADAR RNA-Editing Enzyme to Antagonize RNA-Interference-Mediated Gene Silencing in Caenorhabditis elegans Reviewed International journal
Hiromitsu Ohta, Manabi Fujiwara, Yasumi Ohshima, Takeshi Ishihara
Genetics 2008.10
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Regulation of body size and behavioral state of C. elegans by sensory perception and the EGL-4 cGMP-dependent protein kinase. Reviewed International journal
Fujiwara M, Sengupta P, McIntire S
Neuron 2002.12
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A novel WD40 protein, CHE-2, acts cell-autonomously in the formation of C. elegans sensory cilia. Reviewed International journal
Fujiwara M, Ishihara T, Katsura I.
Development 1999.11
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Behavioral Forgetting of Olfactory Learning Is Mediated by Interneuron-Regulated Network Plasticity in Caenorhabditis elegans. Reviewed International journal
JH Teo, I Kurokawa, Y Onishi, N Sato, T Kitazono, T Tokunaga, M Fujiwara, T Ishihara.
eNeuro 29;9 ( 4 ) 2022.8
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Teo, JHM; Kurokawa, I; Onishi, Y; Sato, N; Kitazono, T; Tokunaga, T; Fujiwara, M; Ishihara, T
ENEURO 9 ( 4 ) 2022.7 （ eISSN:2373-2822 ）
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Environmental responsiveness of tubulin glutamylation in sensory cilia is regulated by the p38 MAPK pathway. Reviewed International journal
Kimura Y, Tsutsumi K, Konno A, Ikegami K, Hameed S, Kaneko T, Kaplan OI, Teramoto T, Fujiwara M, Ishihara T, Blacque OE, Setou M.
Scientific Reports 30 ( 8 ) 8392 2018.5
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Multiple Signaling Pathways Coordinately Regulate Forgetting of Olfactory Adaptation through Control of Sensory Responses in Caenorhabditis elegans Reviewed International journal
Tomohiro Kitazono, Sayuri Hara-Kuge, Osamu Matsuda, Akitoshi Inoue, Manabi Fujiwara, and Takeshi Ishihara
The Journal of Neuroscience 37 ( 42 ) 10240 - 10251 2017.10
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Forgetting in C. elegans is accelerageted by neuronal communication via the TIR-1/JNK-1 pathway Reviewed
Akitoshi Inoue, Etsuko Sawatari, Takayuki Teramoto, Manabi Fujiwara, Takeshi Ishihara
Cell Reports 3 ( 3 ) 808 - 819 2013.3
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An expanded palette of genetically encoded Ca2+ indicators. Reviewed International journal
Zhao Y, Araki S, Wu J, Teramoto T, Chang YF, Nakano M, Abdelfattah AS, Fujiwara M, Ishihara T, Nagai T, Campbell RE.
Science 333 ( 6051 ) 2011.9
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Behavioral choice between conflicting alternatives Is regulated by a receptor guanylyl cyclase, GCY-28, and a Receptor Tyrosine Kinase, SCD-2, in AIA Interneurons of Caenorhabditis elegans. Reviewed International journal
Shinkai Y, Yamamoto Y, Fujiwara M, Tabata T, Murayama T, Hirotsu T, Ikeda DD, Tsunozaki M, Iino Y, Bargmann CI, Katsura I, Ishihara T.
Journal of Neuroscience 31 ( 8 ) 2011.2
Presentations
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線虫の感覚行動のライフサイクルにおける変化
藤原 学, 佐藤 則子, 丸山 新一, 石原 健
第37回日本分子生物学会 2014.11
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How does the animal change its behavioral patterns during growth? International conference
Manabi Fujiwara, Noriko Sato, Shinichi Maruyama, Takeshi Ishihara
C. elegans Development, Cell Biology and Gene Expression Meeting in associated with The 6th Asia-Pacific C. elegans meetin 2014.7
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線虫の感覚行動のライフサイクルにおける変化
藤原 学, 丸山新一, 佐藤則子, 石原 健
日本分子生物学会 2013.12
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線虫の成長に伴う行動変化に関わるミトコンドリアの働き Invited
藤原 学
第３５回日本分子生物学会年会 2012.12
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生殖細胞が制御する線虫の感覚行動 Invited
藤原 学
日本遺伝学会第８４回大会 2012.9
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Chemotaxis behavior is regulated by germline in C. elegans International conference
Manabi Fujiwara
2012 EMBO conference series: C. elegans Neurobiology 2012.6
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Chemotaxis behavior is regulated by germline in C. elegans. International conference
M. Fujiwara*, N. Sato, S. Maruyama, T. Akamine, T. Ishihara
18th International C. elegans meeting 2011.6
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匂いの好みを変化させる性腺シグナルの働きと作用機構
藤原 学、 佐藤 則子、 石原 健（九大、院理）
分子生物学会 2010.12
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Chemotactic control by a germline signal in C. elegans International conference
Manabi Fujiwara, Noriko Satou, Shinichi Maruyama, Taku Akamine, Takeshi Ishihara
17th International C. elegans meeting 2009.6
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Sensory information through cGMP signaling controls the energy homeostasis of C.elegans. International conference
2006.7
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線虫の脳における複数の情報処理の実行機構
藤原 学、#平井祥太、#徳升 太一、石原 健
第44回日本分子生物学会 2021.12
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The regulation of olfactory circuit by EGL-4/PKG International conference
#Takahiro Hino, #Shota Hirai, Takeshi Ishihara, Manabi Fujiwara
IWM2021(International C. elegans meeting on line) 2021.6
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C. elegansにおける餌とフェロモンの情報統合回路の光遺伝学的解析
第42回日本分子生物学会 2019.12
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Long-term modification of the olfactory circuit in C. elegans life span. Invited International conference
Manabi Fujiwara, #Takahiro Hino
2019.11
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Optogenetic analyses of information processing in pheromone and food sensing network
Manabi Fujiwara, #Hinako Yoshida, #Ryoken Yamamoto, Takeshi Ishihara
2019.8
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Gonadal maturation changes chemotaxis behavior and neural processing in the olfactory circuit through the function of a guanylyl cyclase, GCY-28 and ASI neurons. International conference
Manabi Fujiwara, # Hiroshi Wada, # Ryoken Yamamoto, Takeshi Ishihara
International C. elegans meeting 2019.6
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Gonadal maturation changes chemotaxis to a food-associated odorant and neural processing in C. elegans
Manabi Fujiwara, Hiroshi Wada, Takeshi Ishihara
2018.11
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脳と体、体と脳
藤原 学
線虫研究の未来を創る会 2018.9
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Gonadal maturation changes chemotaxis behavior and neural processing in the olfactory circuit through the function of a guanylyl cyclase, GCY-28. International conference
Manabi Fujiwara, Hiroshi Wada, Takeshi Ishihara
Asia-pacific C. elegans meeting 2018.7
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Gonadal maturation changes chemotaxis behavior and neural processing in the olfactory circuit of C. elegans
Manabi Fujiwara, Takeshi Ishihara
2017.7
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Gonadal maturation changes chemotaxis behavior and neural processing in the olfactory circuit through the function of a guanylyl cyclase, GCY-28 International conference
Manabi Fujiwara, Takeshi Ishihara
International C. elegans meeting 2017.6
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Gonadal maturation changes chemotaxis behavior and neural processing in the olfactory circuit of C. elegans International conference
Manabi Fujiwara, Itaru Aoyama, Takahiro Hino, Takayuki Teramoto, Takeshi Ishihara
CeNeuro 2016.7
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Sensory information through cGMP signaling controls the body growth of C.elegans. Invited
Manabi Fujiwara , Steven L. McIntire , Yasumi Ohshima , Takeshi Ishihara
2005.8
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線虫C.elegansの感覚情報をもとにした体長の制御機構
藤原 学、大島 靖美、Steven L. McIntire
日本分子生物学会 2003.12
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CHB-3 and the cGMP signaling pathway regulating dauer formation, chemotaxis and body size. International conference
Manabi Fujiwara, Yasumi Ohshima , Steven L. McIntire
14th International C.elegans meeting 2003.6
MISC
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感覚情報とEGL-4 cGMP依存性蛋白キナーゼによる線虫の体長と行動の制御
藤原 学
実験医学 2003.5
Professional Memberships
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日本分子生物学会
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日本遺伝学会
Academic Activities
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プログラム委員
第47回日本神経科学大会 （ 福岡コンベンションセンター ） 2024.7
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Screening of academic papers
Role(s)： Peer review
2023
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Screening of academic papers
Role(s)： Peer review
2022
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オーガナイザー
線虫研究の未来を創る会 （ オンライン開催 ） 2021.8 - 2021.9
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Screening of academic papers
Role(s)： Peer review
2021
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Screening of academic papers
Role(s)： Peer review
2020
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オーガナイザー
線虫研究の未来を創る会 （ 国立遺伝学研究所 ） 2019.9
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オーガナイザー
線虫研究の未来を創る会 （ 名古屋大学 ） 2019.8
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Screening of academic papers
Role(s)： Peer review
2019
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Screening of academic papers
Role(s)： Peer review
2018
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Screening of academic papers
Role(s)： Peer review
2017
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組織委員 International contribution
（ ソウル ） 2006.11 - Present
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座長（Chairmanship） International contribution
2004.6 - Present
Research Projects
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線虫の冗長な嗅覚回路構造によって可能になる匂い情報の高次処理
Grant number：23K05979 2023 - 2025
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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線虫の冗長な嗅覚回路構造によって可能になる匂い情報の高次処理
Grant number：23K05979 2023 - 2025
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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基盤研究（Ｃ）線虫の性的成熟に伴う感覚情報処理回路の変化とその分子的制御機構の解析
2018.6
Authorship：Principal investigator
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Grant number：17K07503 2017 - 2022
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Fujiwara Manabi
Authorship：Principal investigator Grant type：Scientific research funding
In the nematode C. elegans, the proliferation of germ cells during the growth to adults causes the increase of the ability of worms to approach an odor of food (chemotaxis). Previously we have shown that the AIB neuron, which is a downstream interneuron of the olfactory neuron, changes its responsiveness to the odorant stimuli according to the proliferation of germ cells, and thus regulates the behavioral change. In this study, it was revealed that the guanylate cyclase GCY-28 is involved in the regulation of odor responsiveness of the AIB neuron, and that GCY-28 works in the AIA neuron, which connects to AIB neuron. In addition, it was revealed that the ASI chemosensory neuron, which senses pheromones and other substances, is also involved in changes in the responsiveness of AIB neuron.
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性的成熟に伴う行動変化をコントロールする分子•神経機構
2014
平成２６年度九州大学教育研究プログラム・研究拠点形成プロジェクト（P&P）
Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
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生殖腺によって制御される嗅覚行動の分子基盤と神経回路における情報処理機構の解析
Grant number：23570007 2011 - 2013
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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個体の内的環境によって行動はどのように変化するかー線虫C. elegansを用いた遺伝学的アプローチー
2008 - 2009
女性研究者支援プログラム 出産・育児期研究助成
Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
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体のサイズとエネルギー代謝をコントロールする神経系のホメオスタシス制御の機構
Grant number：17770006 2005 - 2006
科学研究費助成事業 若手研究(B)
Authorship：Principal investigator Grant type：Scientific research funding
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線虫Ｃ．エレガンスにおける感覚情報に依存した体長の制御機構の分子遺伝学的解析
Grant number：15770002 2003 - 2004
科学研究費助成事業 若手研究(B)
Authorship：Principal investigator Grant type：Scientific research funding
Class subject
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生物科学Ⅱ
2023.10 - 2023.12 Fall quarter
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Basic BiologyⅡ
2023.10 - 2023.12 Fall quarter
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生物科学II
2023.10 - 2023.12 Fall quarter
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分子遺伝学
2023.4 - 2023.9 First semester
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細胞生物学
2023.4 - 2023.9 First semester
-
細胞生物学
2023.4 - 2023.9 First semester
-
分子遺伝学
2023.4 - 2023.9 First semester
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生物科学Ⅱ
2022.10 - 2022.12 Fall quarter
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Basic BiologyⅡ
2022.10 - 2022.12 Fall quarter
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生物科学特論Ⅳ
2022.10 - 2022.12 Fall quarter
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Biology, Advanced CouresⅣ
2022.10 - 2022.12 Fall quarter
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生物科学特論IV
2022.10 - 2022.12 Fall quarter
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生物科学II
2022.10 - 2022.12 Fall quarter
-
分子遺伝学
2022.4 - 2022.9 First semester
-
分子遺伝学
2022.4 - 2022.9 First semester
-
細胞生物学
2022.4 - 2022.9 First semester
-
生物科学Ⅱ
2021.10 - 2021.12 Fall quarter
-
Basic BiologyⅡ
2021.10 - 2021.12 Fall quarter
-
生物科学II
2021.10 - 2021.12 Fall quarter
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分子遺伝学
2021.4 - 2021.9 First semester
-
分子遺伝学
2021.4 - 2021.9 First semester
-
細胞生物学
2021.4 - 2021.9 First semester
-
基礎遺伝学実験
2020.10 - 2021.3 Second semester
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細胞生物学
2020.4 - 2020.9 First semester
-
分子遺伝学
2020.4 - 2020.9 First semester
-
基礎遺伝学実験
2019.10 - 2020.3 Second semester
-
分子遺伝学
2019.4 - 2019.9 First semester
-
細胞生物学
2019.4 - 2019.9 First semester
-
基礎遺伝学実験
2018.10 - 2019.3 Second semester
-
分子遺伝学
2018.4 - 2018.9 First semester
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細胞生物学
2018.4 - 2018.9 First semester
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基礎遺伝学実験
2017.10 - 2018.3 Second semester
-
分子遺伝学
2017.4 - 2017.9 First semester
-
細胞生物学
2017.4 - 2017.9 First semester
-
基礎遺伝学実験
2016.10 - 2017.3 Second semester
-
分子遺伝学
2016.4 - 2016.9 First semester
-
細胞生物学
2016.4 - 2016.9 First semester
-
基礎遺伝学実験
2015.10 - 2016.3 Second semester
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分子遺伝学
2015.4 - 2015.9 First semester
-
細胞生物学
2015.4 - 2015.9 First semester
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基礎生体高分子実験
2014.10 - 2015.3 Second semester
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分子遺伝学
2014.4 - 2014.9 First semester
-
基礎生体高分子実験
2013.10 - 2014.3 Second semester
-
分子遺伝学
2013.4 - 2013.9 First semester
-
自然科学総合実験
2013.4 - 2013.9 First semester
-
基礎生体高分子実験
2012.10 - 2013.3 Second semester
-
自然科学総合実験
2012.4 - 2012.9 First semester
-
分子遺伝学
2012.4 - 2012.9 First semester
-
分子遺伝学
2011.4 - 2011.9 First semester
-
自然科学総合実験
2011.4 - 2011.9 First semester
-
分子遺伝学実験
2011.4 - 2011.9 First semester
-
分子遺伝学
2010.4 - 2010.9 First semester
-
分子遺伝学実験
2010.4 - 2010.9 First semester
-
自然科学総合実験
2010.4 - 2010.9 First semester
-
分子遺伝学
2009.4 - 2009.9 First semester
-
分子遺伝学実験
2009.4 - 2009.9 First semester
-
自然科学総合実験
2009.4 - 2009.9 First semester
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生物学演習I
2008.10 - 2009.3 Second semester
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分子遺伝学実験
2008.4 - 2008.9 First semester
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分子遺伝学実験
2007.4 - 2007.9 First semester
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分子遺伝学実験
2006.4 - 2006.9 First semester
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生物学演習 I
2005.10 - 2006.3 Second semester
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分子遺伝学実験
2005.4 - 2005.9 First semester
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生物科学Ⅱ
2024.10 - 2024.12 Fall quarter
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Basic BiologyⅡ
2024.10 - 2024.12 Fall quarter
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システム生命科学特別演習Ⅰ
2024.4 - 2025.3 Full year
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分子遺伝学
2024.4 - 2024.9 First semester
Social Activities
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模擬講義
長崎県五島高校 2020.11
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高校生向け出前講義（長崎県立長崎西高等学校、20081.10.18、「一寸の虫にも五分の魂 ー線虫C. elegansをつかって生物の仕組を探るー」）
2008.10
Travel Abroad
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1999.6 - 2002.9
Staying countory name 1：United States Staying institution name 1：University of Calfornia, San Francisco