ATSUTA YUJI
Organization
Faculty of Sciences Department of Biology Lecturer
School of Sciences Department of Biology（Joint Appointment）
Graduate School of Systems Life Sciences Department of Systems Life Sciences（Joint Appointment）
Title
Lecturer
Contact information
Tel
0928026556
Profile
2023年度の主な活動内容は以下の通りである。
1)研究成果発表・・・研究成果を招待講演や国内学会研究会にて3度発表した（NIBBセミナー、分子生物学会、ユニーク会）。また、私が責任著者、筆頭著者として原著論文2報を出版することができた（Suzuki et al., Cells & Dev., 2023; Atsuta et al., Dev. Cell, 2024）。このうちSuzukiらの論文は指導した大学院生が筆頭著者として貢献し作成した論文である。
2）教育について・・・研究室においては新たに2名の卒研生を受け入れ、共に卒業研究にて良好な成績を収めた。この2名はシス生大学院課程に進学し、継続して指導している。また授業について、2023年度は以下の科目を担当し、精力的に講義・実習指導を行なった【学部授業】生命の科学A、応用分子生物学実習、自然科学総合実験（分担）、発生生物学（分担）、分子発生学（分担）、生物科学演習（分担）
【大学院授業】システム生命科学特別演習I、システム生命科学特別演習II、システム生命科学特別研究、学際開拓創成セミナーI、学際開拓創成セミナーII、生物科学I（分担）、生物科学特論（分担）
External link
ORCID
Degree
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PhD in Developmental Biology
Research History
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2003.4.1-2008.3.31 協和発酵工業株式会社 医薬営業部
2003.4.1-2008.3.31 協和発酵工業株式会社 医薬営業部
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2013.4.1-2015.3.31 京都大学大学院理学研究科 博士研究員 2015.4.1-2020.2.29 ハーバード医科大学遺伝学研究科 博士研究員
Research Interests・Research Keywords
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Research theme：Study for vertebrate limb development -Cellular reprogramming of limb progenitors -Making limb bud-like organoids -Bioelectric signals in limb development -Dissecting mechanisms underlying drug teratogenicity by using limb buds Genetic and epigenetic mechanisms underlying diversity of sternum shapes between species
Keyword：Limb development/regeneration, Direct reprogramming, Organoid, Membrane potential, Sternum development, Keel
Research period： 2020.3
Awards
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NAIST賞（最優秀修了生）
2013.3 奈良先端科学技術大学院大学 管組織形成機構に関する研究
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若手優秀プレゼンテーション賞
2012.5 日本発生生物学会、日本細胞生物学会 生体内における管組織形成機構に関する研究
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Beverly Kerr McKinnell Award （最優秀ポスター賞）
2010.10 生体内の管組織形成機構に関する研究
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優秀学生ポスター賞
2010.8 ウォルフ管をモデルとした管組織形成機構に関する研究。２位。
Papers
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Direct reprogramming of non-limb fibroblasts to cells with properties of limb progenitors Reviewed International journal
Developmental Cell 59 415 - 430 2024.2
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LIN28 is essential for the maintenance of chicken primordial germ cells Reviewed International journal
#Katsuya Suzuki*,#Seung June Kwon*, Daisuke Saito, Yuji Atsuta(Corresponding)
Cells & Development 176 203874 2023.7
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Prime editing in chicken fibroblasts and primordial germ cells Reviewed International journal
Yuji Atsuta, #Katsuya Suzuki, #Hiroko Iikawa, #Haruna Yaguchi, Daisuke Saito
Development, Growth & Differentiation 2022.11
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In ovo electroporation of chicken limb bud ectoderm Reviewed International journal
Reiko R. Tomizawa, Clifford J. Tabin, Yuji Atsuta (corresponding author)
Developmental Dynamics 2021.5
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Repeated mutation of a developmental enhancer contributed to human thermoregulatory evolution Reviewed International journal
Daniel Aldea*, Yuji Atsuta*, Blerina Kokalari, Stephen F. Schaffner, Rexxi D. Prasasya, Adam Aharoni, Heather L. Dingwall, Bailey Warder, Yana G. Kamberov (*equal contribution)
Proceedings of the National Academy of Sciences of the United States of America 118 ( 16 ) e2021722118 2021.4
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L-type voltage-gated Ca2+ channel Ca(V)1.2 regulates chondrogenesis during limb development Invited Reviewed International journal
Atsuta, Yuji; Tomizawa, Reiko R.; Levin, Michael; Tabin, Clifford J.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116 ( 43 ) 21592 - 21601 2019.10
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Early formation of the Mullerian duct is regulated by sequential actions of BMP/Pax2 and FGF/Lim1 signaling Reviewed International journal
Atsuta, Yuji; Takahashi, Yoshiko
DEVELOPMENT 143 ( 19 ) 3549 - 3559 2016.10
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FGF8 coordinates tissue elongation and cell epithelialization during early kidney tubulogenesis Reviewed International journal
Atsuta, Yuji; Takahashi, Yoshiko
DEVELOPMENT 142 ( 13 ) 2329 2015.7
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Transgenesis of the Wolffian duct visualizes dynamic behavior of cells undergoing tubulogenesis in vivo Reviewed International journal
Atsuta, Yuji; Tadokoro, Ryosuke; Saito, Daisuke; Takahashi, Yoshiko
DEVELOPMENT GROWTH & DIFFERENTIATION 55 ( 4 ) 579 - 590 2013.5
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Differential modularity of the mammalian Engrailed 1 enhancer network directs sweat gland development Reviewed International journal
Daniel Aldea, Blerina Kokalari, Yuji Atsuta, Heather L. Dingwall, Ying Zheng, Arben Nace, George Cotsarelis, Yana G. Kamberov
PLoS Genetics 2023.2
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Coordination between body growth and tissue growth: Wolffian duct elongation and somitogenesis proceed in harmony with axial growth Invited Reviewed International journal
Takahashi, Yoshiko; Kudo, Ryo; Tadokoro, Ryosuke; Atsuta, Yuji
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY 62 ( 1-3 ) 79 - 84 2018.5
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Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells. Reviewed International journal
Alan R Rodrigues, Nayuta Yakushiji-Kaminatsui, Yuji Atsuta, Guillaume Andrey, Patrick Schorderet, Denis Duboule, Clifford J Tabin
Proceedings of the National Academy of Sciences of the United States of America 114 ( 12 ) 3139 - 3144 2017.3
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Interepithelial signaling with nephric duct is required for the formation of overlying coelomic epithelial cell sheet Reviewed International journal
Yoshino, Takashi; Saito, Daisuke; Atsuta, Yuji; Uchiyama, Chihiro; Ueda, Shinya; Sekiguchi, Kiyotoshi; Takahashi, Yoshiko
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111 ( 18 ) 6660 - 6665 2014.5
Presentations
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Direct reprogramming of non-limb fibroblasts to cells with properties of limb progenitors Invited
2023.12
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Direct reprogramming of non-limb fibroblasts to cells with properties of limb progenitors International conference
Yuji Atsuta
2022.6
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Making vertebrate limbs from non-limb fibroblasts International conference
Yuji Atsuta
SDB 79th Meeting 2020.7
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Comparative study of the sternal development between chicken and emu
2023.7
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再生しようとする試みから四肢発生を理解する Invited
熱田 勇士
動物・植物・生態学会三学会合同福岡例会 2022.12
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Reprogramming non-limb fibroblasts into limb progenitor-like cells Invited
Atsuta Y.
NAIST Bioscience Seminar 2018.11
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In vivo time-lapse imaging of individual cells in an actively extending kidney rudiment International conference
Atsuta Y., Tadokoro R. and Takahashi Y.
JSDB 42nd Annual Meeting 2009.5
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Tubular formation using Wolffian duct as a model: Tubular extension and cell epithelialization are coordinately regulated
Atsuta Y., Ohata E., Tadokoro R., Saito D. and Takahashi Y.
2009.12
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Tubular formation using Wolffian duct as a model: Tubular extension and cell epithelialization are coordinately regulated. International conference
Atsuta Y., Ohata E., Tadokoro R., Saito D. and Takahashi Y.
2010.3
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Epithelialization and extension of tubular structures are regulated by interactions between neighboring tissues International conference
Atsuta Y., Ohata E., Tadokoro R., Saito D. and Takahashi Y.
JSDB 43rd Annual Meeting 2010.6
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Tubular extension and cell epithelialization are coordinately regulated and influenced by adjacent tissues International conference
Atsuta Y., Ohata E., Tadokoro R., Saito D. and Takahashi Y.
SDB 69th annual meeting 2010.8
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Tubular extension and cell epithelialization are coordinately regulated and influenced by adjacent tissues International conference
Atsuta Y. and Takahashi Y.
The 16th International Conference of ISD 2010.10
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Tubulogenesis using Wolffian duct as a model: FGF signals regulate tubular elongation and cell epithelialization as environmental factors International conference
Atsuta Y. and Takahashi Y.
JSDB 44th Annual Meeting 2011.5
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Tubule elongation and cell epithelialization are coordinately regulated by FGFs emanating from adjacent tissues International conference
Atsuta Y., Ueda S. and Takahashi Y.
2012.5
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Coordination between tubular elongation and cell epithelialization is regulated by FGFs emanating from surrounding tissues International conference
Atsuta Y. and Takahashi Y.
JSDB 46th Annual Meeting 2013.5
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Tubulogenesis using Wolffian duct as a model: Tubule elongation and cell epithelialization are coordinated by FGF signals International conference
Atsuta Y. and Takahashi Y.
SDB 73th Annual Meeting 2014.7
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Designing novel culture systems for long-term expansion of limb bud progenitors International conference
Atsuta Y., Colle C. and Tabin C.
Joint Meeting of the German and JSDB 2017.3
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Assessing the roles of bioelectric signaling in embryonic patterning using the chicken limb bud as a model International conference
Atsuta Y. Levin M. and Tabin C.
SDB 76th Annual Meeting 2017.7
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Reprogramming non-limb fibroblasts into limb bud progenitor-like cells International conference
Atsuta Y., Rodrigues A., Lee C., Colle C. and Tabin C.
Society for Developmental Biologists (SDB) 77th Annual Meeting 2018.7
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Reprogramming non-limb fibroblasts into limb bud progenitor-like cells
Atsuta Y., Lee C., Rodrigues A. and Tabin C.
2018.11
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Assessing the roles of bioelectric signaling in embryonic patterning using vertebrate limb buds International conference
Atsuta Y., Tomizawa R., Levin M. and Tabin C.
JSDB 52nd Annual Meeting 2019.5
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Reprogramming non-limb fibroblasts into limb bud progenitor-like cells International conference
Atsuta Y. and Tabin C.
EMBO workshop. Limb Development and Regeneration: New Tools for a Classic Model System 2019.7
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Tubule elongation and cell epithelialization are regulated by FGF signals emanating from adjacent tissues Invited International conference
Atsuta Y., Ueda S. and Takahashi Y.
2012.1
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Tubulogenesis using Wolffian duct as a model: Tubule elongation and cell epithelialization are coordinated by FGF signals. Invited International conference
Atsuta Y. and Takahashi Y.
Japanese Society of Developmental Biologists (JSDB) 47th Annual Meeting 2014.5
MISC
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翻訳: 「ギルバート発生生物学」第12章「沿軸中胚葉と中間中胚葉」 Reviewed
熱田 勇士
メディカル・サイエンス・インターナショナル 2015.3
Professional Memberships
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Japanese Society of Developmental Biologists
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Society for Developmental Biology
Academic Activities
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Screening of academic papers
Role(s)： Peer review
2023
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Screening of academic papers
Role(s)： Peer review
2022
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Frontiers in Cell and Developmental Biology International contribution
2021.11 - 2023.10
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Screening of academic papers
Role(s)： Peer review
2021
Research Projects
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内藤記念次世代育成支援研究助成金/非四肢細胞を用いて肢芽組織を再現する試み
2024
Grant type：Donation
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蛇足創出ロードマップ
2022 - 2024
戦略的創造研究推進事業 (文部科学省)
Authorship：Principal investigator Grant type：Contract research
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発生現象を模倣し四肢復元再生技術の基盤を構築する
Grant number：21K06201 2021
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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住友財団基礎科学研究助成/竜骨突起形成メカニズムの解明
2021
Grant type：Donation
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オルガノイドファインチューニング技術によるヒト四肢組織再構成
2021
理研ー九大ハブ研究
Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
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ダイレクトリプログラミングと3次元培養系を駆使した四肢様オルガノドの創出
Grant number：20K22658 2020 - 2021
日本学術振興会 科学研究費助成事業 研究活動スタート支援
Authorship：Principal investigator Grant type：Scientific research funding
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加藤記念研究助成メディカルサイエンス分野/線維芽細胞から四肢前駆細胞を産み出すリプログラミング法の確立と四肢構造の再現
2020
Grant type：Donation
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線維芽細胞から手足をつくる: 四肢前駆細胞を生み出す細胞リプログラミング法の確立
2017 - 2018
日本学術振興会 海外特別研究員
Authorship：Principal investigator Grant type：Joint research
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生体内における上皮管構造の形成と伸長の制御機構
2010 - 2012
日本学術振興会 特別研究員
Authorship：Principal investigator Grant type：Joint research
Class subject
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分子発生学
2024.10 - 2025.3 Second semester
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生物科学Ⅰ
2024.4 - 2024.6 Spring quarter
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Basic BiologyⅠ
2024.4 - 2024.6 Spring quarter
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基礎科学実習
2023.12 - 2024.2 Winter quarter
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分子発生学
2023.10 - 2024.3 Second semester
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発生生物学
2023.10 - 2024.3 Second semester
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自然科学総合実験
2023.10 - 2023.12 Fall quarter
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生命の科学Ａ
2023.6 - 2023.8 Summer quarter
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応用分子生物学実験
2023.4 - 2023.9 First semester
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基礎科学実習
2022.12 - 2023.2 Winter quarter
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発生生物学（1月28日分）
2022.10 - 2023.3 Second semester
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生物学演習I
2022.10 - 2023.3 Second semester
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自然科学総合実験
2022.10 - 2022.12 Fall quarter
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細胞生物学（第１４回分）
2022.4 - 2022.9 First semester
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応用分子生物学実験
2022.4 - 2022.9 First semester
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生物学演習I
2021.10 - 2022.3 Second semester
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自然科学総合実験
2021.10 - 2021.12 Fall quarter
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基礎科学実習
2021.4 - 2021.9 First semester
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分子発生学（第６回講義分）
2021.4 - 2021.9 First semester
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応用分子生物学実験
2021.4 - 2021.9 First semester
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自然科学総合実験
2020.12 - 2021.2 Winter quarter
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応用分子生物学実験
2020.10 - 2021.3 Second semester
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自然科学総合実験
2020.10 - 2020.12 Fall quarter
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細胞生物学（第13回分）
2020.4 - 2020.9 First semester
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分子発生学（第11回分）
2020.4 - 2020.9 First semester
Media Coverage
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Webコラムに研究内容紹介記事が掲載された（2023年3月8日）。 タイトル「ヘビに足を生えさせる？ 奇抜な研究の深～い意味」 Newspaper, magazine
読売新聞オンライン 2023.3