Updated on 2024/11/07

Information

 

写真a

 
YAMADA HISAKATA
 
Organization
Faculty of Medical Sciences Department of Clinical Medicine Academic Researcher
Title
Academic Researcher
Contact information
メールアドレス
Tel
0926426962
Profile
education, clinilcal and basic research
External link

Degree

  • MD PhD

Research History

  • Lunds Universitet 2000.5 - 2003.10

Research Interests・Research Keywords

  • Research theme:Elucidating the regulatory mechanism of host defense system in health and disease.

    Keyword:Immunology

    Research period: 2004.4

Papers

  • Contributions of the N-terminal flanking residues of an antigenic peptide from the Japanese cedar pollen allergen Cry j 1 to the T-cell activation by HLA-DP5 Invited Reviewed International journal

    Kusano S, Ueda S, Oryoji D, Toyoumi A, Hashimoto-Tane A, Kishi H, Hamana H, Muraguchi A, Jin H, Arase H, Miyadera H, Kishikawa R, Yoshikai Y, Yamada H, Yamamoto K, Nishimura Y, Saito T, Sasazuki T, Yokoyama S

    International Immunology   2023.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/intimm/dxad024

  • Low avidity observed for anti-citrullinated peptide antibody is not a general phenomenon for autoantibodies Invited Reviewed International journal

    Yamada H, Haraguchi A, Tsuru T, Kondo M, Sagawa F, Niiro H, Nakashima Y

    Annals of Rheumatic Diseases   2023.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/ard-2023-224303

  • The Search for the Pathogenic T Cells in the Joint of Rheumatoid Arthritis: Which T-Cell Subset Drives Autoimmune Inflammation? Invited Reviewed International journal

    Yamada H

    International Journal of Molecular Sciences   24 ( 8 )   6930   2023.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.3390/ijms24086930

  • Is there a reduction in hip destruction under a treat-to-target strategy in patients with rheumatoid arthritis? Invited Reviewed International journal

    Tsushima H, Takahide S, Akasaki Y, Fujiwara T, Hara D, Ikemura S, Sakuraba K, Kamura S, Miyahara H, Yamada H, Fukushi JI, Nakashima Y.

    Modern Rheumatology   2023.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1093/mr/road021

  • Factors affecting patient satisfaction related to cost and treatment effectiveness in rheumatoid arthritis: results from the multicenter observational cohort study, FRANK Registry. Invited Reviewed International journal

    Fujiwara T, Kondo M, Yamada H, Haraguchi A, Fujimura K, Sakuraba K, Kamura S, Fukushi JI, Miyahara H, Inoue Y, Tsuru T, Shuto T, Yoshizawa S, Suematsu E, Miyamura T, Ayano M, Mitoma H, Arinobu Y, Niiro H, Ohishi M, Hirata A, Tokunaga S, Takada A, Hara D, Tsushima H, Akasaki Y, Ikemura S, Sueishi T, Toya M, Sakuragi T, Tsutsui T, Kai K, Arisumi S, Nakashima Y.

    Arthritis Research & Therapy   24 ( 1 )   53   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1186/s13075-022-02746-5

  • G protein-coupled receptor kinase 5 deletion suppresses synovial inflammation in a murine model of collagen antibody-induced arthritis Reviewed

    Masakazu Toya, Yukio Akasaki, Takuya Sueishi, Ichiro Kurakazu, Masanari Kuwahara, Taisuke Uchida, Tomoaki Tsutsui, Hidetoshi Tsushima, Hisakata Yamada, Martin K. Lotz, Yasuharu Nakashima

    Scientific Reports   11 ( 1 )   2021.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-90020-0

  • Autoreactivity of Peripheral Helper T Cells in the Joints of Rheumatoid Arthritis Reviewed

    Takahide Sakuragi, Hisakata Yamada, Akihisa Haraguchi, Kazuhiro Kai, Jun-ichi Fukushi, Satoshi Ikemura, Yukio Akasaki, Toshifumi Fujiwara, Hidetoshi Tsushima, Tomoko Tsutsui, Masakazu Kondo, Yasunobu Yoshikai, Seiji Okada, Yasuharu Nakashima

    The Journal of Immunology   206 ( 9 )   2045 - 2051   2021.5

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.4049/jimmunol.2000783

  • Adaptive immunity in the joint of rheumatoid arthritis Invited Reviewed

    Hisakata Yamada

    Immunological Medicine   1 - 11   2021.5

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/25785826.2021.1930371

  • Human PD-1hiCD8+ T Cells Are a Cellular Source of IL-21 in Rheumatoid Arthritis Reviewed

    Kazuhiko Higashioka, Motoki Yoshimura, Takahide Sakuragi, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Nobuyuki Ono, Yojiro Arinobu, Makoto Kikukawa, Hisakata Yamada, Takahiko Horiuchi, Koichi Akashi, Hiroaki Niiro

    Frontiers in Immunology   12   2021.3

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fimmu.2021.654623

  • Type 1 helper T cells generate CXCL9/10-producing T-bet+ effector B cells potentially involved in the pathogenesis of rheumatoid arthritis Reviewed

    Tsuyoshi Nakayama, Motoki Yoshimura, Kazuhiko Higashioka, Kohta Miyawaki, Yuri Ota, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Nobuyuki Ono, Yojiro Arinobu, Makoto Kikukawa, Hisakata Yamada, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro

    Cellular Immunology   360   104263 - 104263   2021.2

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cellimm.2020.104263

  • Activation of TLR4 signaling inhibits progression of osteosarcoma by stimulating CD8-positive cytotoxic lymphocytes Reviewed

    Kenichiro Yahiro, Yoshihiro Matsumoto, Hisakata Yamada, Makoto Endo, Nokitaka Setsu, Toshifumi Fujiwara, Makoto Nakagawa, Atsushi Kimura, Eijiro Shimada, Seiji Okada, Yoshinao Oda, Yasuharu Nakashima

    Cancer Immunology, Immunotherapy   69 ( 5 )   745 - 758   2020.5

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00262-020-02508-9

  • Abatacept reduces disease activity of rheumatoid arthritis independently of modulating anti-citrullinated peptide antibody production Reviewed

    Hisakata Yamada, Tomomi Tsuru, Takeshi Otsuka, Masayuki Maekawa, Hiroshi Harada, Takaaki Fukuda, Hiroshi Tsukamoto, Akira Maeyama, Shigeru Yoshizawa, Ken Wada, Yasuharu Nakashima, Eisuke Shono, Seiji Yoshizawa, Hiroshi Jojima, Masakazu Kondo

    Immunological Medicine   43 ( 2 )   87 - 91   2020.4

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/25785826.2020.1718833

  • IL-7R–Dependent Phosphatidylinositol 3-Kinase Competes with the STAT5 Signal to Modulate T Cell Development and Homeostasis Reviewed

    204 ( 4 )   844 - 857   2020.2

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.4049/jimmunol.1900456

  • CCR6+ group 3 innate lymphoid cells accumulate in inflamed joints in rheumatoid arthritis and produce Th17 cytokines Reviewed

    Ayako Takaki-Kuwahara, Yojiro Arinobu, Kohta Miyawaki, Hisakata Yamada, Hirofumi Tsuzuki, Kensuke Irino, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Hiroshi Tsukamoto, Takahiko Horiuchi, Hiroaki Niiro, Koichi Akashi

    Arthritis Research & Therapy   21 ( 1 )   2019.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13075-019-1984-x

  • Drug survival rates of biological disease-modifying antirheumatic drugs and Janus kinase-inhibitor therapy in 801 rheumatoid arthritis patients: a 14 year-retrospective study from a rheumatology clinic in Japan Reviewed

    Masakazu Kondo, Hisakata Yamada

    Modern Rheumatology   29 ( 6 )   928 - 935   2019.11

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/14397595.2018.1537556

  • Development of a new monoclonal antibody specific to mouse Vγ6 chain Reviewed

    2 ( 3 )   e201900363 - e201900363   2019.6

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    There are seven Vγ gene segments in the TCR γ chain loci of mice. We developed monoclonal antibodies (mAbs) specific to the Vγ6 chain (Heilig & Tonegawa nomenclature). By immunizing Vγ4/6 KO mice with complementarity-determining region peptides in Vγ6 chains, we generated three hybridomas. These hybridomas produced mAbs capable of cell surface staining of Vγ6/Vδ1 gene–transfected T-cell line lacking TCR as well as of Vγ1 Vγ4 Vγ5 Vγ7 γδ T cells and the CD3high TCRδint γδ T cells in various organs. The location of Vγ6+ γδ T cells, which peaked in the newborn thymus, was associated with mTEC. In vivo administration of clone 1C10-1F7 mAb impaired protection against <italic>Klebsiella pneumoniae</italic> infection but ameliorated psoriasis-like dermatitis induced by imiquimod treatment. These new mAbs are useful to elucidate the development, location, and functions of Vγ6 γδ T cells in mice.

    DOI: 10.26508/lsa.201900363

  • Cutting Edge: B Cells Expressing Cyclic Citrullinated Peptide–Specific Antigen Receptor Are Tolerized in Normal Conditions Reviewed

    201 ( 12 )   3492 - 3496   2018.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.4049/jimmunol.1800826

  • T cells specific for post-translational modifications escape intrathymic tolerance induction Reviewed

    Nature Communications   9 ( 1 )   2018.12

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    DOI: 10.1038/s41467-017-02763-y

  • Interleukin-21 Induces Short-Lived Effector CD8 + T Cells but Does Not Inhibit Their Exhaustion after Mycobacterium bovis BCG Infection in Mice Reviewed

    Naoto Noguchi, Risa Nakamura, Shinya Hatano, Hisakata Yamada, Xun Sun, Naoya Ohara, Yasunobu Yoshikai

    Infection and Immunity   86 ( 8 )   2018.8

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/iai.00147-18

  • Serum IgG ACPA-IgM RF immune complexes were detected in rheumatoid arthritis patients positive for IgM ACPA Reviewed

    Haraguchi A, Yamada H, Kondo M, Okazaki K, Fukushi JI, Oyamada A, Yoshikai Y, Nakashima Y

    Clin Exp Rheumatol   36 ( 4 )   612 - 618   2018.6

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  • Crucial role of P2X7 receptor for effector T cell activation in experimental autoimmune uveitis Reviewed

    Atsunobu Takeda, Hisakata Yamada, Eiichi Hasegawa, Mitsuru Arima, Shoji Notomi, Sayaka Myojin, Takeru Yoshimura, Toshio Hisatomi, Hiroshi Enaida, Ryoji Yanai, Kazuhiro Kimura, Tatsuro Ishibashi, Koh-Hei Sonoda

    Japanese Journal of Ophthalmology   62 ( 3 )   398 - 406   2018.5

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10384-018-0587-4

  • Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4 Reviewed

    Immunity   48 ( 2 )   286 - 298.e6   2018.2

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.immuni.2018.01.004

  • CD5 − NK1.1 + γδ T Cells that Develop in a Bcl11b-Independent Manner Participate in Early Protection against Infection Reviewed

    21 ( 5 )   1191 - 1202   2017.10

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    DOI: 10.1016/j.celrep.2017.10.007

  • Minimum 10-year results of cementless total hip arthroplasty in patients with rheumatoid arthritis Reviewed

    Akihisa Haraguchi, Yasuharu Nakashima, Hisaaki Miyahara, Yukio Esaki, Ken Okazaki, Jun-ichi Fukushi, Go Hirata, Satoshi Ikemura, Satoshi Kamura, Koji Sakuraba, Kenjiro Fujimura, Yukio Akasaki, Hisakata Yamada

    Modern Rheumatology   27 ( 4 )   598 - 604   2017.7

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/14397595.2016.1256024

  • Th1 is the predominant helper T cell subset that produces GM-CSF in the joint of rheumatoid arthritis Reviewed

    Hisakata Yamada, Akihisa Haraguchi, Koji Sakuraba, Ken Okazaki, Jun-Ichi Fukushi, Hideki Mizu-Uchi, Yukio Akasaki, Yukio Esaki, Satoshi Kamura, Kenjiro Fujimura, Masakazu Kondo, Hisaaki Miyahara, Yasuharu Nakashima, Yasunobu Yoshikai

    RMD Open   3 ( 1 )   e000487 - e000487   2017.7

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/rmdopen-2017-000487

  • Generation mechanism of RANKL+ effector memory B cells: relevance to the pathogenesis of rheumatoid arthritis Reviewed

    Yuri Ota, Hiroaki Niiro, Shun-ichiro Ota, Naoko Ueki, Hirofumi Tsuzuki, Tsuyoshi Nakayama, Koji Mishima, Kazuhiko Higashioka, Siamak Jabbarzadeh-Tabrizi, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Akiko Kukita, Hisakata Yamada, Hiroshi Tsukamoto, Koichi Akashi

    Arthritis Research & Therapy   18 ( 1 )   2016.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13075-016-0957-6

  • Two Types of Interleukin 17A–Producing γδ T Cells in Protection Against Pulmonary Infection WithKlebsiella pneumoniae Reviewed

    214 ( 11 )   1752 - 1761   2016.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/infdis/jiw443

  • Interleukin-21 signaling in B cells, but not in T cells, is indispensable for the development of collagen-induced arthritis in mice Reviewed

    Koji Sakuraba, Akiko Oyamada, Kenjiro Fujimura, Rosanne Spolski, Yukihide Iwamoto, Warren J. Leonard, Yasunobu Yoshikai, Hisakata Yamada

    Arthritis Research & Therapy   18 ( 1 )   2016.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13075-016-1086-y

  • Antitumor activity of recombinant Bacille Calmette-Guérin secreting interleukin-15-Ag85B fusion protein against bladder cancer Reviewed

    35   327 - 331   2016.6

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.intimp.2016.03.007

  • Delayed diagnosis of ankylosing spondylitis in a Japanese population Reviewed

    Yasuharu Nakashima, Masanobu Ohishi, Ken Okazaki, Jun-Ichi Fukushi, Akiko Oyamada, Daisuke Hara, Toshio Doi, Yukio Akasaki, Hisakata Yamada, Yukihide Iwamoto

    Modern Rheumatology   26 ( 3 )   421 - 425   2016.5

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.3109/14397595.2015.1088679

  • Outcome of Joint-Preserving Arthroplasty for Rheumatoid Forefoot Deformities Reviewed

    Jun-ichi Fukushi, Yasuharu Nakashima, Ken Okazaki, Hisakata Yamada, Taro Mawatari, Masanobu Ohishi, Akiko Oyamada, Yukio Akasaki, Yukihide Iwamoto

    Foot & Ankle International   37 ( 3 )   262 - 268   2016.3

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/1071100715609981

  • Requirement of CD30 expression on CD4 T cells in the pathogenesis of experimental autoimmune encephalomyelitis Reviewed

    Koji Shinoda, Xun Sun, Akiko Oyamada, Hisakata Yamada, Jun-ichi Kira, Yasunobu Yoshikai

    Journal of Neuroimmunology   291   39 - 45   2016.2

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    DOI: 10.1016/j.jneuroim.2015.12.005

  • Prevalence of dyslipidemia in Japanese patients with rheumatoid arthritis and effects of atorvastatin treatment Reviewed

    Mio Akiyama, Taro Mawatari, Yasuharu Nakashima, Hisaaki Miyahara, Hisakata Yamada, Ken Okazaki, Jun-ichi Fukushi, Masakazu Kondo, Junji Kishimoto, Chinami Hashimura, Yukihide Iwamoto

    Clinical Rheumatology   34 ( 11 )   1867 - 1875   2015.11

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10067-015-3049-0

  • Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes Reviewed

    6 ( 1 )   2015.11

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ncomms7748

  • An Enhancer of the IL-7 Receptor α-Chain Locus Controls IL-7 Receptor Expression and Maintenance of Peripheral T Cells Reviewed

    195 ( 7 )   3129 - 3138   2015.10

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.4049/jimmunol.1302447

  • Brief Report: Successful In Vitro Culture of Rheumatoid Arthritis Synovial Tissue Explants at the Air-Liquid Interface Reviewed

    Koji Sakuraba, Kenjiro Fujimura, Yasuharu Nakashima, Ken Okazaki, Jun-ichi Fukushi, Masanobu Ohishi, Akiko Oyamada, Yukio Esaki, Hisaaki Miyahara, Yukihide Iwamoto, Yasunobu Yoshikai, Hisakata Yamada

    Arthritis & Rheumatology   67 ( 4 )   887 - 892   2015.4

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/art.39019

  • Renal cancer treatment with recipient lymphocyte infusion enhanced the antitumor effect of nonmyeloablative allogeneic stem cell transplantation Reviewed

    Ario Takeuchi, Masatoshi Eto, Katsunori Tatsugami, Hisakata Yamada, Akira Yokomizo, Masaki Shiota, Momoe Itsumi, Junichi Inokuchi, Keijiro Kiyoshima, Takashi Dejima, Kenjiro Imada, Seiji Naito, Yasunobu Yoshikai

    Transplant Immunology   32 ( 2 )   131 - 139   2015.3

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.trim.2014.12.001

  • CD30 ligand is a new therapeutic target for central nervous system autoimmunity Reviewed

    Koji Shinoda, Xun Sun, Akiko Oyamada, Hisakata Yamada, Hiromi Muta, Eckhard R. Podack, Jun-ichi Kira, Yasunobu Yoshikai

    Journal of Autoimmunity   57   14 - 23   2015.2

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jaut.2014.11.005

  • A Genome-Wide Analysis Identifies a Notch–RBP-Jκ–IL-7Rα Axis That Controls IL-17–Producing γδ T Cell Homeostasis in Mice Reviewed

    194 ( 1 )   243 - 251   2015.1

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.4049/jimmunol.1401619

  • EBI3 is pivotal for the initiation of experimental autoimmune uveitis Reviewed

    Atsunobu Takeda, Eiichi Hasegawa, Takako Fukuhara, Sayaka Hirakawa, Hisakata Yamada, Yang Yang, Takeru Yoshimura, Toshio Hisatomi, Yuji Oshima, Hiroki Yoshida, Koh-Hei Sonoda, Tatsuro Ishibashi

    Experimental Eye Research   125   107 - 113   2014.8

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.exer.2014.06.004

  • Tyk2-Dependent Bystander Activation of Conventional and Nonconventional Th1 Cell Subsets Contributes to Innate Host Defense againstListeria monocytogenesInfection Reviewed

    Tomomitsu Hashiguchi, Akiko Oyamada, Koji Sakuraba, Kazuya Shimoda, Keiichi I. Nakayama, Yukihide Iwamoto, Yasunobu Yoshikai, Hisakata Yamada

    The Journal of Immunology   192 ( 10 )   4739 - 4747   2014.5

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    DOI: 10.4049/jimmunol.1303067

  • IFN-γ–Producing and IL-17–Producing γδ T Cells Differentiate at Distinct Developmental Stages in Murine Fetal Thymus Reviewed International journal

    192 ( 5 )   2210 - 2218   2014.3

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    γδ T cells develop at the double-negative (DN) 2 and DN3 stages and acquire functions to produce IL-17 and IFN-γ in fetal thymus. However, the relationship between differentiation stages and their functions was unclear. In this study, we found that, although IFN-γ-producing and IL-17-producing γδ T cells developed from DN2 cells, only IFN-γ-producing γδ T cells developed from DN3 cells, indicating the direct generation of IL-17-producing γδ T cells from the DN2 stage, not through the DN3 stage. Single-cell analysis revealed that DN2 cells contained heterogeneous γδ T cell precursors with or without an ability to develop IL-17 producers. Inactivation of B cell leukemia/lymphoma 11b, a zinc finger transcription factor responsible for transition from early to late stages of DN2 cells, completely abrogated the development of IL-17-producing γδ T cells, although a unique subset of IFN-γ-producing γδ T cells expressing a high level of promyelocytic leukemia zinc finger was able to develop. Thus, our results reveal that γδ T cells are functionally differentiated to IFN-γ and IL-17 producers at different developmental stages in fetal thymus.

    DOI: 10.4049/jimmunol.1302145

  • Identification of Independent Susceptible and Protective HLA Alleles in Japanese Autoimmune Thyroid Disease and Their Epistasis Reviewed

    Sho Ueda, Daisuke Oryoji, Ken Yamamoto, Jaeduk Yoshimura Noh, Ken Okamura, Mitsuhiko Noda, Koichi Kashiwase, Yuka Kosuga, Kenichi Sekiya, Kaori Inoue, Hisakata Yamada, Akiko Oyamada, Yasuharu Nishimura, Yasunobu Yoshikai, Koichi Ito, Takehiko Sasazuki

    The Journal of Clinical Endocrinology & Metabolism   99 ( 2 )   E379 - E383   2014.2

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    DOI: 10.1210/jc.2013-2841

  • Type I Interferon Plays Opposing Roles in Cytotoxicity and Interferon-γ Production by Natural Killer and CD8 T Cells after Influenza A Virus Infection in Mice.

    2014.1

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  • A C-type lectin receptor pathway is responsible for the pathogenesis of acute cyclophosphamide-induced cystitis in mice Reviewed International journal

    Takashi Dejima, Kensuke Shibata, Hisakata Yamada, Ario Takeuchi, Hiromitsu Hara, Masatoshi Eto, Seiji Naito, Yasunobu Yoshikai

    Microbiology and Immunology   57 ( 12 )   833 - 841   2013.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1348-0421.12100

  • Effects of adalimumab administration in bio-naïve and bio-switch rheumatoid arthritis patients in daily clinical practice : two-year results from single center.

    2013.11

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  • CD30L/CD30 is critical for maintenance of IL-17A-producing γδ T cells bearing Vγ6 in mucosa-associated tissues in mice Reviewed

    6 ( 6 )   1191 - 1201   2013.11

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/mi.2013.18

  • CD30 Is Required for Activation of a Unique Subset of Interleukin-17A-Producing γδ T Cells in Innate Immunity against Mycobacterium bovis Bacillus Calmette-Guérin Infection Reviewed International journal

    81 ( 10 )   3923 - 3934   2013.10

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    <title>ABSTRACT</title>Interleukin-17A (IL-17A)-producing γδ T cells are known to be activated following<named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">Mycobacterium bovis</named-content>bacillus Calmette-Guérin (BCG) infection. Here, we show that CD30, a member of the tumor necrosis factor (TNF) receptor superfamily, is important for activation of IL-17A-producing γδ T cells after BCG infection. Vγ1Vγ4γδ T cells preferentially expressing Vγ6/Vδ1 genes were identified as the major source of IL-17A in the peritoneal cavity during the early stage of BCG infection. The number of IL-17A-producing Vγ1Vγ4γδ T cells bearing Vγ6 increased in peritoneal exudate cells (PEC) of wild-type (WT) mice but not in those of CD30 knockout (KO) mice in response to BCG infection. Consistently, CD30 ligand (CD30L) or CD30 expression, predominantly by Vγ1Vγ4γδ T cells, was rapidly upregulated after BCG infection. Inhibition of CD30L/CD30 signaling by<italic>in vivo</italic>administration of a soluble CD30 and immunoglobulin fusion protein (CD30-Ig) severely impaired activation of IL-17A-producing Vγ1Vγ4γδ T cells in WT mice, while stimulating CD30L/CD30 signaling by<italic>in vivo</italic>administration of agonistic anti-CD30 monoclonal antibody (MAb) restored IL-17A production by Vγ1Vγ4γδ T cells in CD30L KO mice after BCG infection. These results suggest that CD30 signaling plays an important role in the activation of IL-17A-producing Vγ1Vγ4γδ T cells bearing Vγ6 at an early stage of BCG infection.

    DOI: 10.1128/iai.00887-13

  • Type I interferon limits influenza virus-induced acute lung injury by regulation of excessive inflammation in mice Reviewed International journal

    Yojiro Arimori, Risa Nakamura, Hisakata Yamada, Kensuke Shibata, Naoyoshi Maeda, Tetsuo Kase, Yasunobu Yoshikai

    Antiviral Research   99 ( 3 )   230 - 237   2013.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.antiviral.2013.05.007

  • CD4 T cell-intrinsic IL-2 signaling differentially affects Th1 and Th17 development Reviewed

    Kenjiro Fujimura, Akiko Oyamada, Yukihide Iwamoto, Yasunobu Yoshikai, Hisakata Yamada

    Journal of Leukocyte Biology   94 ( 2 )   271 - 279   2013.8

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1189/jlb.1112581

  • Positive selection of self-antigen-specific CD8+T cells by hematopoietic cells Reviewed International journal

    Hisakata Yamada, Kensuke Shibata, Koji Sakuraba, Kenjiro Fujimura, Yasunobu Yoshikai

    European Journal of Immunology   43 ( 8 )   2033 - 2042   2013.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/eji.201242957

  • C-type Lectin MCL Is an FcRγ-Coupled Receptor that Mediates the Adjuvanticity of Mycobacterial Cord Factor Reviewed

    38 ( 5 )   1050 - 1062   2013.5

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.immuni.2013.03.010

  • Ly6C+Ly6G−Myeloid-derived suppressor cells play a critical role in the resolution of acute inflammation and the subsequent tissue repair process after spinal cord injury Reviewed

    125 ( 1 )   74 - 88   2013.4

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    DOI: 10.1111/jnc.12135

  • Y-box binding protein-1 regulates cell proliferation and is associated with clinical outcomes of osteosarcoma Reviewed

    Y Fujiwara-Okada, Y Matsumoto, J Fukushi, N Setsu, S Matsuura, S Kamura, T Fujiwara, K Iida, M Hatano, A Nabeshima, H Yamada, M Ono, Y Oda, Y Iwamoto

    British Journal of Cancer   108 ( 4 )   836 - 847   2013.3

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    DOI: 10.1038/bjc.2012.579

  • Naturally Occurring PD-1+ Memory Phenotype CD8 T Cells Belong to Nonconventional CD8 T Cells and Are Cyclophosphamide-Sensitive Regulatory T Cells Reviewed International journal

    Koji Sakuraba, Kensuke Shibata, Yukihide Iwamoto, Yasunobu Yoshikai, Hisakata Yamada

    The Journal of Immunology   190 ( 4 )   1560 - 1566   2013.2

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    DOI: 10.4049/jimmunol.1202464

  • Evaluation of cartilage degradation in arthritis using T1ρ magnetic resonance imaging mapping Reviewed

    32 ( 9 )   2867 - 2875   2012.9

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    DOI: 10.1007/s00296-011-2140-3

  • Age-related differences in cellular and molecular profiles of inflammatory responses after spinal cord injury Reviewed

    Hiromi Kumamaru, Hirokazu Saiwai, Yasuyuki Ohkawa, Hisakata Yamada, Yukihide Iwamoto, Seiji Okada

    Journal of Cellular Physiology   227 ( 4 )   1335 - 1346   2012.4

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    DOI: 10.1002/jcp.22845

  • Direct isolation and RNA-seq reveal environment-dependent properties of engrafted neural stem/progenitor cells Reviewed

    Hiromi Kumamaru, Yasuyuki Ohkawa, Hirokazu Saiwai, Hisakata Yamada, Kensuke Kubota, Kazu Kobayakawa, Koichi Akashi, Hideyuki Okano, Yukihide Iwamoto, Seiji Okada

    Nature Communications   3 ( 1 )   2012.1

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    DOI: 10.1038/ncomms2132

  • A reduction of recipient regulatory T cells by cyclophosphamide contributes to an anti-tumor effect of nonmyeloablative allogeneic stem cell transplantation in mice Reviewed

    Ario Takeuchi, Masatoshi Eto, Hisakata Yamada, Katsunori Tatsugami, Seiji Naito, Yasunobu Yoshikai

    International Journal of Cancer   130 ( 2 )   365 - 376   2012.1

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    DOI: 10.1002/ijc.26009

  • Protective Role of Naturally Occurring Interleukin-17A-Producing γδ T Cells in the Lung at the Early Stage of Systemic Candidiasis in Mice Reviewed

    79 ( 11 )   4503 - 4510   2011.11

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    <title>ABSTRACT</title>

    Interleukin-17A (IL-17A)-producing γδ T cells differentiate in the fetal thymus and reside in the peripheral tissues, such as the lungs of naïve adult mice. We show here that naturally occurring γδ T cells play a protective role in the lung at a very early stage after systemic infection with
    <named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">Candida albicans.</named-content>
    Selective depletion of neutrophils by
    <italic>in vivo</italic>
    administration of anti-Ly6G monoclonal antibody (MAb) impaired fungal clearance more prominently in the lung than in the kidney 24 h after intravenous infection with
    <named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">C. albicans.</named-content>
    Rapid and transient production of IL-23 was detected in the lung at 12 h, preceding IL-17A production and the influx of neutrophils, which reached a peak at 24 h after infection. IL-17A knockout (KO) mice showed reduced infiltration of neutrophils concurrently with impaired fungal clearance in the lung after infection. The major source of IL-17A was the γδ T cell population in the lung, and Cδ KO mice showed little IL-17A production and reduced neutrophil infiltration after infection. Early IL-23 production in a TLR2/MyD88-dependent manner and IL-23-triggered tyrosine kinase 2 (Tyk2) signaling were essential for IL-17A production by γδ T cells. Thus, our study demonstrated a novel role of naturally occurring IL-17A-producing γδ T cells in the first line of host defense against
    <named-content xmlns:xlink="http://www.w3.org/1999/xlink" content-type="genus-species" xlink:type="simple">C. albicans</named-content>
    infection.

    DOI: 10.1128/iai.05799-11

  • The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice Reviewed

    Takafumi Fuchiwaki, Xun Sun, Kenjiro Fujimura, Hisakata Yamada, Kensuke Shibata, Hiromi Muta, Eckhard R. Podack, Hideyuki Kawauchi, Yasunobu Yoshikai

    European Journal of Immunology   41 ( 10 )   2947 - 2954   2011.10

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    DOI: 10.1002/eji.201141423

  • Innate memory phenotype CD4+ T cells play a role in early protection against infection by Listeria monocytogenes in a CD30L-dependent manner Reviewed

    Kenji Umeda, Xun Sun, Ying Guo, Hisakata Yamada, Kensuke Shibata, Yasunobu Yoshikai

    Microbiology and Immunology   55 ( 9 )   645 - 656   2011.9

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    DOI: 10.1111/j.1348-0421.2011.00362.x

  • Macrophage Infiltration Predicts a Poor Prognosis for Human Ewing Sarcoma Reviewed

    Toshifumi Fujiwara, Jun-ichi Fukushi, Shunsaku Yamamoto, Yoshihiro Matsumoto, Nokitaka Setsu, Yoshinao Oda, Hisakata Yamada, Seiji Okada, Kosuke Watari, Mayumi Ono, Michihiko Kuwano, Satoshi Kamura, Keiichiro Iida, Yuko Okada, Mihoko Koga, Yukihide Iwamoto

    The American Journal of Pathology   179 ( 3 )   1157 - 1170   2011.9

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    DOI: 10.1016/j.ajpath.2011.05.034

  • Preferential Accumulation of Activated Th1 Cells Not Only in Rheumatoid Arthritis But Also in Osteoarthritis Joints Reviewed

    HISAKATA YAMADA, YASUHARU NAKASHIMA, KEN OKAZAKI, TARO MAWATARI, JUN-ICHI FUKUSHI, AKIKO OYAMADA, KENJIRO FUJIMURA, YUKIHIDE IWAMOTO, YASUNOBU YOSHIKAI

    The Journal of Rheumatology   38 ( 8 )   1569 - 1575   2011.8

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    DOI: 10.3899/jrheum.101355

  • Notch-Hes1 pathway is required for the development of IL-17–producing γδ T cells Reviewed

    118 ( 3 )   586 - 593   2011.7

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    <title>Abstract</title>
    Unlike conventional T cells, which are exported from the thymus as naive cells and acquire effector functions upon antigen encounter in the periphery, a subset of γδ T cells differentiates into effectors that produce IL-17 within the fetal thymus. We demonstrate here that intrathymic development of the naturally occurring IL-17–producing γδ T cells is independent of STAT3 and partly dependent on RORγt. Comparative gene-expression analysis identified Hes1, one of the basic helix-loop-helix proteins involved in Notch signaling, as a factor specifically expressed in IL-17–producing γδ T cells. Hes1 is critically involved in the development of IL-17–producing γδ T cells, as evidenced by their severe decrease in the thymi of Hes1-deficient fetal mice. Delta-like 4 (Dll4)–expressing stromal cells support the development of IL-17–producing γδ T cells in vitro. In addition, conditional Hes1 ablation in peripheral γδ T cells decreases their IL-17 production but not their IFN-γ production. These results reveal a unique differentiation pathway of IL-17–producing γδ T cells.

    DOI: 10.1182/blood-2011-02-334995

  • IL-17 production by γδ T cells is important for the antitumor effect of Mycobacterium bovis bacillus Calmette-Guérin treatment against bladder cancer

    41 ( 1 )   246 - 251   2011.1

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    DOI: 10.1002/eji.201040773

  • CD30 Ligand Is a Target for a Novel Biological Therapy against Colitis Associated with Th17 Responses Reviewed

    Xun Sun, Hisakata Yamada, Kensuke Shibata, Hiromi Muta, Kenzaburo Tani, Eckhard R. Podack, Yoichiro Iwakura, Yasunobu Yoshikai

    The Journal of Immunology   185 ( 12 )   7671 - 7680   2010.12

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    DOI: 10.4049/jimmunol.1002229

  • Mechanism of Synergistic Antitumor Effect of Sorafenib and Interferon-α on Treatment of Renal Cell Carcinoma Reviewed

    184 ( 6 )   2549 - 2556   2010.12

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    DOI: 10.1016/j.juro.2010.07.033

  • CD30 Ligand/CD30 Plays a Critical Role in Th17 Differentiation in Mice Reviewed

    Xun Sun, Hisakata Yamada, Kensuke Shibata, Hiromi Muta, Kenzaburo Tani, Eckhard R. Podack, Yasunobu Yoshikai

    The Journal of Immunology   185 ( 4 )   2222 - 2230   2010.8

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    DOI: 10.4049/jimmunol.1000024

  • Current perspectives on the role of IL-17 in autoimmune disease Invited Reviewed

    Hisakata Yamada

    Journal of Inflammation Research   33 - 33   2010.6

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    DOI: 10.2147/jir.s6375

  • Interleukin-15 Is Critical in the Pathogenesis of Influenza A Virus-Induced Acute Lung Injury Reviewed

    Risa Nakamura, Naoyoshi Maeda, Kensuke Shibata, Hisakata Yamada, Tetsuo Kase, Yasunobu Yoshikai

    Journal of Virology   84 ( 11 )   5574 - 5582   2010.6

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    DOI: 10.1128/jvi.02030-09

  • Antibody-Mediated T-Cell Reduction or Increased Levels of Chimerism Overcome Resistance to Cyclophosphamide-Induced Tolerance in NKT-Deficient Mice Reviewed

    T. Onzuka, Y. Tomita, S. Okano, I. Shimizu, H. Yamada, Y. Yoshikai, R. Tominaga

    Scandinavian Journal of Immunology   72 ( 2 )   106 - 117   2010.5

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    DOI: 10.1111/j.1365-3083.2010.02417.x

  • The LTB4-BLT1 Axis Mediates Neutrophil Infiltration and Secondary Injury in Experimental Spinal Cord Injury Reviewed

    Hirokazu Saiwai, Yasuyuki Ohkawa, Hisakata Yamada, Hiromi Kumamaru, Akihito Harada, Hideyuki Okano, Takehiko Yokomizo, Yukihide Iwamoto, Seiji Okada

    The American Journal of Pathology   176 ( 5 )   2352 - 2366   2010.5

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    DOI: 10.2353/ajpath.2010.090839

  • Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation Reviewed

    Kazuhito Gotoh, Yoshihiko Tanaka, Akihiko Nishikimi, Risa Nakamura, Hisakata Yamada, Naoyoshi Maeda, Takahiro Ishikawa, Katsuaki Hoshino, Takehito Uruno, Qinhong Cao, Sadayuki Higashi, Yasushi Kawaguchi, Munechika Enjoji, Ryoichi Takayanagi, Tsuneyasu Kaisho, Yasunobu Yoshikai, Yoshinori Fukui

    Journal of Experimental Medicine   207 ( 4 )   721 - 730   2010.4

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    DOI: 10.1084/jem.20091776

  • Dual specificity phosphatase16 is a negative regulator of c-Jun NH2-terminal kinase activity in T cells Reviewed

    Shino Kumabe, Momoe Itsumi, Hisakata Yamada, Toshiki Yajima, Tetsuya Matsuguchi, Yasunobu Yoshikai

    Microbiology and Immunology   54 ( 2 )   105 - 111   2010.2

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    DOI: 10.1111/j.1348-0421.2009.00188.x

  • Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle Reviewed

    Eri Ishikawa, Tetsuaki Ishikawa, Yasu S. Morita, Kenji Toyonaga, Hisakata Yamada, Osamu Takeuchi, Taroh Kinoshita, Shizuo Akira, Yasunobu Yoshikai, Sho Yamasaki

    Journal of Experimental Medicine   206 ( 13 )   2879 - 2888   2009.12

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    DOI: 10.1084/jem.20091750

  • Tyrosine Kinase 2 Plays Critical Roles in the Pathogenic CD4 T Cell Responses for the Development of Experimental Autoimmune Encephalomyelitis Reviewed

    Akiko Oyamada, Hiori Ikebe, Momoe Itsumi, Hirokazu Saiwai, Seiji Okada, Kazuya Shimoda, Yoichiro Iwakura, Keiichi I. Nakayama, Yukihide Iwamoto, Yasunobu Yoshikai, Hisakata Yamada

    The Journal of Immunology   183 ( 11 )   7539 - 7546   2009.12

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    DOI: 10.4049/jimmunol.0902740

  • Oral administration of xanthan gum enhances antitumor activity through Toll-like receptor 4 Reviewed

    Ario Takeuchi, Yoriyuki Kamiryou, Hisakata Yamada, Masatoshi Eto, Kensuke Shibata, Kennichi Haruna, Seiji Naito, Yasunobu Yoshikai

    International Immunopharmacology   9 ( 13-14 )   1562 - 1567   2009.12

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    DOI: 10.1016/j.intimp.2009.09.012

  • Effects of Lipopolysaccharide on the Induction of Mixed Chimerism in Cyclophosphamide-Induced Tolerance Reviewed

    T. Onzuka, Y. Tomita, I. Shimizu, S. Okano, H. Yamada, Y. Yoshikai, R. Tominaga

    Scandinavian Journal of Immunology   70 ( 5 )   423 - 430   2009.11

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    DOI: 10.1111/j.1365-3083.2009.02314.x

  • Protective Role of Fas-FasL Signaling in Lethal Infection with Herpes Simplex Virus Type 2 in Mice

    Takahiro Ishikawa, Hisakata Yamada, Akiko Oyamada, Fumi Goshima, Yukihiro Nishiyama, Yasunobu Yoshikai

    Journal of Virology   83 ( 22 )   11777 - 11783   2009.11

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    DOI: 10.1128/jvi.01006-09

  • IL-15 is critical for the maintenance and innate functions of self-specific CD8+T cells Reviewed

    Momoe Itsumi, Yasunobu Yoshikai, Hisakata Yamada

    European Journal of Immunology   39 ( 7 )   1784 - 1793   2009.7

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    DOI: 10.1002/eji.200839106

  • IL-15 protects antigen-specific CD8+T cell contraction afterMycobacterium bovisbacillus Calmette-Guérin infection Reviewed

    86 ( 1 )   187 - 194   2009.7

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    DOI: 10.1189/jlb.0608363

  • Donor CD4 T Cells Are Critical in Allogeneic Stem Cell Transplantation against Murine Solid Tumor Reviewed

    Yoriyuki Kamiryo, Masatoshi Eto, Hisakata Yamada, Toshiki Yajima, Masahiko Harano, Ario Takeuchi, Katsunori Tatsugami, Masumitsu Hamaguchi, Seiji Naito, Yasunobu Yoshikai

    Cancer Research   69 ( 12 )   5151 - 5158   2009.6

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    DOI: 10.1158/0008-5472.can-08-2517

  • Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity Reviewed

    Yukari Shinozaki, Sen Wang, Yoshiyuki Miyazaki, Kohji Miyazaki, Hisakata Yamada, Yasunobu Yoshikai, Hiromitsu Hara, Hiroki Yoshida

    International Journal of Cancer   124 ( 6 )   1372 - 1378   2009.3

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    DOI: 10.1002/ijc.24107

  • A Novel Role of CD30L/CD30 Signaling by T-T Cell Interaction in Th1 Response against Mycobacterial Infection Reviewed

    Ce Tang, Hisakata Yamada, Kensuke Shibata, Hiromi Muta, Worawidh Wajjwalku, Eckhard R. Podack, Yasunobu Yoshikai

    The Journal of Immunology   181 ( 9 )   6316 - 6327   2008.11

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    DOI: 10.4049/jimmunol.181.9.6316

  • Role of the Cytokine Profiles Produced by Invariant Natural Killer T Cells in the Initial Phase of Cyclophosphamide-Induced Tolerance Reviewed

    Tatsushi Onzuka, Yukihiro Tomita, Ichiro Shimizu, Shinji Okano, Hisakata Yamada, Yasunobu Yoshikai, Ryuji Tominaga

    Transplantation   86 ( 9 )   1301 - 1310   2008.11

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    DOI: 10.1097/tp.0b013e318187265e

  • Identification of CD25+ γδ T Cells As Fetal Thymus-Derived Naturally Occurring IL-17 Producers Reviewed

    181 ( 9 )   5940 - 5947   2008.11

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    DOI: 10.4049/jimmunol.181.9.5940

  • The Cytokine RANKL Produced by Positively Selected Thymocytes Fosters Medullary Thymic Epithelial Cells that Express Autoimmune Regulator Reviewed

    Yu Hikosaka, Takeshi Nitta, Izumi Ohigashi, Kouta Yano, Naozumi Ishimaru, Yoshio Hayashi, Mitsuru Matsumoto, Koichi Matsuo, Josef M. Penninger, Hiroshi Takayanagi, Yoshifumi Yokota, Hisakata Yamada, Yasunobu Yoshikai, Jun-ichiro Inoue, Taishin Akiyama, Yousuke Takahama

    Immunity   29 ( 3 )   438 - 450   2008.9

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    DOI: 10.1016/j.immuni.2008.06.018

  • Tyk2-Signaling Plays an Important Role in Host Defense against Escherichia coli through IL-23-Induced IL-17 Production by γδ T Cells Reviewed

    181 ( 3 )   2071 - 2075   2008.8

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    DOI: 10.4049/jimmunol.181.3.2071

  • Comparative histopathological analysis between tenosynovitis and joint synovitis in rheumatoid arthritis Reviewed

    N Kaibara, H Yamada, T Shuto, Y Nakashima, K Okazaki, H Miyahara, Y Esaki, G Hirata, Y Iwamoto

    Histopathology   52 ( 7 )   856 - 864   2008.6

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    DOI: 10.1111/j.1365-2559.2008.03050.x

  • Efficacy of Recombinant Bacille Calmette‐Guérin Vaccine Secreting Interleukin‐15/Antigen 85B Fusion Protein in Providing Protection againstMycobacterium tuberculosis Reviewed

    197 ( 9 )   1263 - 1274   2008.5

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    DOI: 10.1086/586902

  • A Critical Role of CD30 Ligand/CD30 in Controlling Inflammatory Bowel Diseases in Mice Reviewed

    Xun Sun, Shinichi Somada, Kensuke Shibata, Hiromi Muta, Hisakata Yamada, Hirofumi Yoshihara, Kuniomi Honda, Kazuhiko Nakamura, Ryhoichi Takayanagi, Kenzaburo Tani, Eckhard R. Podack, Yasunobu Yoshikai

    Gastroenterology   134 ( 2 )   447 - 458.e3   2008.2

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    DOI: 10.1053/j.gastro.2007.11.004

  • A regulatory role of interleukin 15 in wound healing and mucosal infection in mice Reviewed

    Yoshiko Kagimoto, Hisakata Yamada, Takahiro Ishikawa, Naoyoshi Maeda, Fumi Goshima, Yukihiro Nishiyama, Masutaka Furue, Yasunobu Yoshikai

    Journal of Leukocyte Biology   83 ( 1 )   165 - 172   2008.1

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    DOI: 10.1189/jlb.0307137

  • Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis Reviewed

    H Yamada, Y Nakashima, K Okazaki, T Mawatari, J-I Fukushi, N Kaibara, A Hori, Y Iwamoto, Y Yoshikai

    Annals of the Rheumatic Diseases   67 ( 9 )   1299 - 1304   2007.11

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    DOI: 10.1136/ard.2007.080341

  • IL-15 exacerbates collagen-induced arthritis with an enhanced CD4+ T cell response to produce IL-17 Reviewed

    Kazufumi Yoshihara, Hisakata Yamada, Akiko Hori, Toshiki Yajima, Chiharu Kubo, Yasunobu Yoshikai

    European Journal of Immunology   37 ( 10 )   2744 - 2752   2007.10

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    DOI: 10.1002/eji.200737229

  • Interleukin-15 selectively expands CD57+CD28−CD4+ T cells, which are increased in active rheumatoid arthritis Reviewed

    124 ( 3 )   328 - 335   2007.9

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    DOI: 10.1016/j.clim.2007.06.001

  • In vivo treatment with a nonapeptide thymic hormone, facteur thymique serique (FTS), ameliorates chronic colitis induced by dextran sulphate sodium in mice Reviewed

    Xun Sun, Hisakata Yamada, Kazufumi Yoshihara, Akira Awaya, Yasunobu Yoshikai

    International Immunopharmacology   7 ( 7 )   928 - 936   2007.7

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    DOI: 10.1016/j.intimp.2007.02.014

  • Resident Vδ1+γδ T Cells Control Early Infiltration of Neutrophils afterEscherichia coliInfection via IL-17 Production Reviewed

    178 ( 7 )   4466 - 4472   2007.4

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    DOI: 10.4049/jimmunol.178.7.4466

  • Tyk2 Signaling in Host Environment Plays an Important Role in Contraction of Antigen-Specific CD8+T Cells following a Microbial Infection Reviewed

    Wei Li, Hisakata Yamada, Toshiki Yajima, Ryusuke Nakagawa, Kazuya Shimoda, Keiichi Nakayama, Yasunobu Yoshikai

    The Journal of Immunology   178 ( 7 )   4482 - 4488   2007.4

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    DOI: 10.4049/jimmunol.178.7.4482

  • H2-M3-Restricted CD8+T Cells Induced by Peptide-Pulsed Dendritic Cells Confer Protection againstMycobacterium tuberculosis Reviewed

    Takehiko Doi, Hisakata Yamada, Toshiki Yajima, Worawidh Wajjwalku, Toshiro Hara, Yasunobu Yoshikai

    The Journal of Immunology   178 ( 6 )   3806 - 3813   2007.3

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    DOI: 10.4049/jimmunol.178.6.3806

  • Lipopolysaccharide inhalation exacerbates allergic airway inflammation by activating mast cells and promoting Th2 responses Reviewed

    D. Murakami, H. Yamada, T. Yajima, A. Masuda, S. Komune, Y. Yoshikai

    Clinical & Experimental Allergy   37 ( 3 )   339 - 347   2007.3

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    DOI: 10.1111/j.1365-2222.2006.02633.x

  • Enforced Expression of Bcl-2 Partially Restores Cell Numbers but Not Functions of TCRγδ Intestinal Intraepithelial T Lymphocytes in IL-15-Deficient Mice Reviewed

    178 ( 2 )   757 - 764   2007.1

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    DOI: 10.4049/jimmunol.178.2.757

  • IL-15 prevents allergic rhinitis through reactivation of antigen-specific CD8+ cells Reviewed

    N AOI, T MASUDA, D MURAKAMI, T YAJIMA, H MIZUBUCHI, H YAMADA, H KAWAUCHI, Y YOSHIKAI

    Journal of Allergy and Clinical Immunology   117 ( 6 )   1359 - 1366   2006.6

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    DOI: 10.1016/j.jaci.2006.02.018

  • Impaired Protection againstMycobacterium bovisBacillus Calmette-Guérin Infection in IL-15-Deficient Mice Reviewed

    176 ( 4 )   2496 - 2504   2006.2

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    DOI: 10.4049/jimmunol.176.4.2496

  • Pristane, a Non-Antigenic Adjuvant, Induces MHC Class II-Restricted, Arthritogenic T Cells in the Rat Reviewed

    Jens Holmberg, Jonatan Tuncel, Hisakata Yamada, Shemin Lu, Peter Olofsson, Rikard Holmdahl

    The Journal of Immunology   176 ( 2 )   1172 - 1179   2006.1

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    DOI: 10.4049/jimmunol.176.2.1172

  • The major T cell epitope on type II collagen is glycosylated in normal cartilage but modified by arthritis in both rats and humans Reviewed

    European Journal of Immunology   35 ( 2 )   357 - 366   2005.2

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    DOI: 10.1002/eji.200425637

  • A Transient Post-Translationally Modified Form of Cartilage Type II Collagen Is Ignored by Self-Reactive T Cells Reviewed

    Hisakata Yamada, Balik Dzhambazov, Robert Bockermann, Thomas Blom, Rikard Holmdahl

    The Journal of Immunology   173 ( 7 )   4729 - 4735   2004.10

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    DOI: 10.4049/jimmunol.173.7.4729

  • The Critical Role of Fas-Fas Ligand Interaction in Donor-Specific Transfusion-Induced Tolerance to H-Y Antigen Reviewed

    Ryosuke Minagawa, Shinji Okano, Yukihiro Tomita, Kenji Kishihara, Hisakata Yamada, Kenichi Nomoto, Mitsuo Shimada, Yoshihiko Maehara, Keizo Sugimachi, Yasunobu Yoshikai, Kikuo Nomoto

    Transplantation   78 ( 6 )   799 - 806   2004.9

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/01.tp.0000129799.96439.6f

  • Mechanism of murine Vγ1+ γ δ T cell-mediated innate immune response againstListeria monocytogenes infection Reviewed

    32 ( 4 )   928 - 935   2002.4

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/1521-4141(200204)32:4<928::aid-immu928>3.0.co;2-i

  • Involvement of CD4+,CD57+ T cells in the disease activity of rheumatoid arthritis Reviewed

    Takeshi Maeda, Hisakata Yamada, Ryuji Nagamine, Toshihide Shuto, Yasuharu Nakashima, Go Hirata, Yukihide Iwamoto

    Arthritis & Rheumatism   46 ( 2 )   379 - 384   2002.2

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/art.10133

  • The molecular pathogenesis of collagen-induced arthritis in mice—a model for rheumatoid arthritis Reviewed

    1 ( 1 )   135 - 147   2002.2

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/s0047-6374(01)00371-2

  • Evidence of the extrathymic development of tyrosinase-related protein-2-recognizing CD8+ T cells with low avidity Reviewed

    Mamoru Harada,, Hisakata Yamada, Katsunori Tatsugami, Kikuo Nomoto

    Immunology   104 ( 1 )   67 - 74   2001.9

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1046/j.1365-2567.2001.01278.x

  • Reevaluation of the origin of CD44high "memory phenotype" CD8 T cells: comparison between memory CD8 T cells and thymus-independent CD8 T cells Reviewed

    Hisakata Yamada, Goro Matsuzaki, QiJie Chen, Yukihide Iwamoto, Kikuo Nomoto

    European Journal of Immunology   31 ( 6 )   1917 - 1926   2001.6

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/1521-4141(200106)31:6<1917::aid-immu1917>3.0.co;2-f

  • CYCLOPHOSPHAMIDE-INDUCED TOLERANCE IN RAT ORTHOTOPIC LIVER TRANSPLANTATION1 Reviewed

    Shinji Okano, Masatoshi Eto, Yukihiro Tomita, Tomoharu Yoshizumi, Hisakata Yamada, Ryosuke Minagawa, Kenichi Nomoto, Keizo Sugimachi, Kikuo Nomoto

    Transplantation   71 ( 3 )   447 - 456   2001.2

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/00007890-200102150-00019

  • Persistent infection with Listeria monocytogenes in the kidney induces anti-inflammatory invariant fetal-type γδ T cells Reviewed

    102 ( 1 )   94 - 102   2001.1

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1046/j.1365-2567.2001.01149.x

  • Successful Priming and Tolerization of T Cells to Orally Administered Antigens in B-Cell-Deficient Mice Reviewed

    Asako Hashimoto, Hisakata Yamada, Goro Matsuzaki, Kikuo Nomoto

    Cellular Immunology   207 ( 1 )   36 - 40   2001.1

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1006/cimm.2000.1738

  • Unusual cytotoxic activities of thymus-independent, self-antigen-specific CD8+ T cells Reviewed

    Hisakata Yamada, Goro Matsuzaki, Yukihide Iwamoto, Kikuo Nomoto

    International Immunology   12 ( 12 )   1677 - 1683   2000.12

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/intimm/12.12.1677

  • TCR-Independent Activation of Extrathymically Developed, Self Antigen-Specific T Cells by IL-2/IL-15 Reviewed

    Hisakata Yamada, Takahiko Nakamura, Goro Matsuzaki, Yukihide Iwamoto, Kikuo Nomoto

    The Journal of Immunology   164 ( 4 )   1746 - 1752   2000.2

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.4049/jimmunol.164.4.1746

  • Positive Selection of Extrathymically Developed T Cells by Self-antigens Reviewed

    Hisakata Yamada, Toshiharu Ninomiya, Asako Hashimoto, Koji Tamada, Hiroaki Takimoto, Kikuo Nomoto

    Journal of Experimental Medicine   188 ( 4 )   779 - 784   1998.8

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1084/jem.188.4.779

  • Macrophages activated by Listeria monocytogenes induce organ‐specific autoimmunity Reviewed

    K.‐H. SONODA, G. MATSUZAKI, A. NOMURA, H. YAMADA, S. HAMANO, T. NAKAMURA, A. MUKASA, K. NOMOTO

    92 ( 2 )   274 - 283   1997.10

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1046/j.1365-2567.1997.00342.x

  • p56lckis not essential for the T-cell response to allo-MHC antigens Reviewed

    H. YAMADA, Y.-Y. KONG, K. KISHIHARA, T. W. MAK, K. NOMOTO

    Immunology   92 ( 1 )   33 - 38   1997.9

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1046/j.1365-2567.1997.d01-2297.x

  • The characterization of testicular cell (TC)‐specific T‐cell clones induced by intratesticular Listeria monocytogenes infection: TC‐specific T cells with atypical cytokine profile transfer orchitis Reviewed

    G. MATSUZAKI, K.‐H. SONODA, A. MUKASA, H. YAMADA, T. NAKAMURA, H. IKEBE, S. HAMANO, K. NOMOTO

    91 ( 4 )   520 - 528   1997.8

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1046/j.1365-2567.1997.00306.x

  • Enhanced generation of NK cells with intact cytotoxic function in CD45 exon 6-deficient mice Reviewed

    Yamada H, Kishihara K, Kong YY, Nomoto K

    J Immunol   157 ( 4 )   1523 - 1528   1996.8

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Books

  • レビンソン微生物学・免疫学

    山田 久方( Role: Joint translator)

    2012.10 

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    Language:Japanese   Book type:Scholarly book

  • 疾患モデルの作製と利用-免疫疾患

    山田 久方( Role: Joint author)

    2011.6 

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    Language:Japanese   Book type:Scholarly book

  • エッセンシャル免疫学 第2版

    平野俊夫、村上正晃、鍔田武志、福井宣規、阪口篤雄、松井健、鈴木春己、湊長博、濱崎洋子、烏山一、審良静男、加藤博己、菅村和夫、小池隆夫、橋本陶子、吉開泰信、山田久方、清野宏、吉田理人

    2010.8 

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    Book type:General book, introductory book for general audience

  • エッセンシャル免疫学

    平野俊夫、村上正晃、鍔田武志、福井宣規、阪口篤雄、松井健、鈴木春己、湊長博、濱崎洋子、烏山一、審良静男、加藤博己、菅村和夫、小池隆夫、橋本陶子、吉開泰信、山田久方、清野宏、吉田理人

    2007.3 

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    Book type:Scholarly book

Presentations

  • ヒト関節リウマチとTh17細胞 Invited

    山田久方

    第37回日本臨床免疫学会総会  2009.11 

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    Event date: 2009.11

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 関節リウマチ滑膜組織培養法の開発

    櫻庭康司, 藤村謙次郎, 宮原寿明, 江崎幸雄, 岩本 幸英, 吉開 泰信, 山田 久方

    第42回日本臨床免疫学会総会  2014.9 

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    Event date: 2014.9

    Language:Japanese  

    Venue:東京都   Country:Japan  

  • 自己II型コラーゲンの転写後修飾が自己免疫寛容に及ぼす影響

    山田 久方, Johan Backlund, 小山田 亜希子, Rikard Holmdahl, 吉開 泰信

    第41回日本臨床免疫学会総会  2013.11 

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    Event date: 2013.11

    Language:Japanese  

    Venue:下関市   Country:Japan  

  • 異なるTh1細胞サブセットの分化、機能におけるTyk2の役割

    橋口智光, 小山田 亜希子, 櫻庭康司, 吉開 泰信, 山田 久方

    第24回日本生体防御学会学術総会  2013.7 

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    Event date: 2013.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:熊本市   Country:Japan  

  • アダリムマブはBio-naiveでMTX併用の関節リウマチにおいて寛解導入・維持に有用である

    田代泰隆、中島康晴、岡崎賢、馬渡太郎、福士純一、糸川高史、大石正信、山田久方、岩本幸英

    第56回日本リウマチ学会総会・学術集会  2012.4 

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    Event date: 2012.4

    Country:Japan  

  • 抗原特異的Th17細胞のクローン増殖におけるIL-2の役割

    藤村謙次郎、橋口智光、櫻庭康司、小山田亜希子、岩本幸英、吉開泰信、山田久方

    第56回日本リウマチ学会総会・学術集会  2012.4 

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    Event date: 2012.4

    Country:Japan  

  • 内科と整形外科とのチーム医療 整形外科の立場から

    中島康晴、山田久方、岡崎賢、馬渡太郎、福士純一、糸川高史、大石正信、田代泰隆、岩本幸英

    第56回日本リウマチ学会総会・学術集会  2012.4 

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    Event date: 2012.4

    Country:Japan  

  • 関節リウマチにおけるBio-naiveおよびswitch症例でのアダリムマブ使用成績

    田代泰隆、中島康晴、岡崎賢、馬渡太郎、福士純一、糸川高史、大石正信、山田久方、橋爪誠、岩本幸英

    第43回九州リウマチ学会  2012.3 

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    Event date: 2012.3

    Country:Japan  

  • 生物製剤投与中にTHAの遅発性感染が発生したRAの1例

    福徳款章、中島康晴、大石正信、岡崎賢、馬渡太郎、福士純一、糸川高史、田代泰隆、山田久方、岩本幸英

    第43回九州リウマチ学会  2012.3 

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    Event date: 2012.3

    Country:Japan  

  • 関節リウマチの最新の病因論 Invited

    山田久方

    2012.3 

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    Event date: 2012.3

    Presentation type:Oral presentation (invited, special)  

    Venue:名古屋   Country:Japan  

  • Differential requirement for IL-2-signaling in clonal expansion of Th1 and Th17 cells in vivo

    FujimuraKenjiro, Oyamada Akiko, Yoshikai Yasunobu, Yamada Hisakata

    2011.11 

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    Event date: 2011.11

    Country:Japan  

  • The critical role of CD30L in early protection against Listeria monocytogenes in innate γδ T cells in mice

    第40回日本免疫学会総会・学術集会  2011.11 

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    Event date: 2011.11

    Country:Japan  

  • Regulatory CD8 T cells expressing CD122 and programmed death-1 are distinct subset of memory phenotype CD8 T cells

    Sakuraba Koji, Fujimura Kenjiro, Oyamada Akiko, Yoshikai Yasunobu, Yamada Hisakata

    2011.11 

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    Event date: 2011.11

    Country:Japan  

  • The critical role of CD30L in maintenance and activation of naturally occurring IL-17A-producing gammadelta T cells in mice.

    Sun Xun, Guo Ying, Shibata Kensuke, Huang Yinxia, Yamada Hisakata, Muta Hiromi, Eckhard R. Podack, Yoshikai Yasunobu,

    2011.11 

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    Event date: 2011.11

    Country:Japan  

  • The role of Tyk2 in maintenance and activation of naturally occurring IL-17A-producing γδ T cells in mice.

    第40回日本免疫学会総会・学術集会  2011.11 

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    Event date: 2011.11

    Country:Japan  

  • A protective role of naturally occurring IL-17A-producing γδ T cells in the lung at the early stage of systemic candidiasis in mice

    第40回日本免疫学会総会・学術集会  2011.11 

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    Event date: 2011.11

    Country:Japan  

  • IL-7-receptor-α-mediated signaling is required for the development of naturally occurring IL-17-producing γδ T cells in the adult thymus

    第40回日本免疫学会総会・学術集会  2011.11 

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    Event date: 2011.11

    Country:Japan  

  • Naturally occurring IL-17-producing γδ T cells commit at the DN2 stage of mouse fetal thymus in Notch-dependent manner.

    第40回日本免疫学会総会・学術集会  2011.11 

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    Event date: 2011.11

    Country:Japan  

  • Type I interferon limits acute lung injury caused by influenza A H1N1 virus via down-modulation of excessive immune responses in mice.

    ARIMORI Yojiro, Nakamura Risa, Maeda Naoyoshi, Shibata Kensuke, Yamada Hisakata, Kase Tetsuo, Yoshikai Yasunobu

    2011.11 

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    Event date: 2011.11

    Country:Japan  

  • The possibility of the treatment targeting Interleukin-15 or CD8 T cells against the pathogenesis of influenza A virus–induced acute lung injury.

    第40回日本免疫学会総会・学術集会  2011.11 

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    Event date: 2011.11

    Country:Japan  

  • Hematopoietic cell-induced positive selection of self antigen-specific CD8 T cells.

    Yamada Hisakata, Yoshikai Yasunobu

    2011.11 

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    Event date: 2011.11

    Country:Japan  

  • 抗原特異的Th17細胞増殖におけるIL-2レセプターaの役割

    藤村謙次郎、小山田亜希子、岩本幸英、吉開泰信、山田久方

    第55回日本リウマチ学会総会・学術集会  2011.7 

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    Event date: 2011.7

    Country:Japan  

  • 関節リウマチにおける脊椎強度評価 -骨皮質シェルと海面骨の加重分担-

    馬渡太郎、中島康晴、山田久方、岡崎賢、福士純一、糸川高史、大石正信、田代泰隆、T.M. Keaveny、岩本幸英

    第55回日本リウマチ学会総会・学術集会  2011.7 

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    Event date: 2011.7

    Country:Japan  

  • マイコバクテリア感染に関与するT細胞応答におけるTyrosine kinase 2 (Tyk2)の重要性

    小山田亜希子、吉開泰信、山田久方

    第22回日本生体防御学会学術総会  2011.7 

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    Event date: 2011.6 - 2011.7

    Country:Japan  

  • Notch-Hes1経路は自然発生IL-17産生γδT細胞分化に必要である

    柴田健輔、山田久方、吉開泰信

    第22回日本生体防御学会学術総会  2011.6 

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    Event date: 2011.6 - 2011.7

    Country:Japan  

  • IL-17による自然発生IL-17産生γδT細胞機能制御機構の解析

    中村真隆、柴田健輔、山田久方、吉開泰信

    第22回日本生体防御学会学術総会  2011.6 

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    Event date: 2011.6 - 2011.7

    Country:Japan  

  • 自然発生IL-17産生γδT細胞活性化におけるCD30Ligandの役割

    孫遜、郭颖、黄銀霞、柴田健輔、山田久方、吉開泰信

    第22回日本生体防御学会学術総会  2011.6 

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    Event date: 2011.6 - 2011.7

    Country:Japan  

  • Candida albicans感染防御におけるIL-17産生γδT細胞の役割

    出嶋卓、柴田健輔、山田久方、吉開泰信

    第22回日本生体防御学会学術総会  2011.6 

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    Event date: 2011.6 - 2011.7

    Country:Japan  

  • 致死性インフルエンザ感染におけるⅠ型インターフェロンの役割

    有森陽二郎、中村梨沙、柴田健輔、山田久方、吉開泰信

    第22回日本生体防御学会学術総会  2011.6 

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    Event date: 2011.6 - 2011.7

    Country:Japan  

  • インターロイキン‐15を標的にしたインフルエンザAウイルス感染による急性肺障害の治療の開発研究

    中村梨沙、前田直良、柴田健輔、山田久方、加瀬哲男、樗木俊聡、吉開泰信

    第22回日本生体防御学会学術総会  2011.6 

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    Event date: 2011.6 - 2011.7

    Country:Japan  

  • ヒト関節リウマチにおけるCD4T細胞サブセットの検討

    山田久方、吉開泰信

    第22回日本生体防御学会学術総会  2011.6 

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    Event date: 2011.6 - 2011.7

    Country:Japan  

  • 抗原特異的Th17細胞のクローン増殖におけるIL-2の役割

    藤村謙次郎、櫻庭康司、小山田亜希子、吉開泰信、山田久方

    第22回日本生体防御学会学術総会  2011.6 

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    Event date: 2011.6 - 2011.7

    Country:Japan  

  • 免疫制御作用を持つメモリー型PD-1陽性CD8T細胞の特徴

    櫻庭康司、小山田亜希子、藤村謙次郎、吉開泰信、山田久方

    第22回日本生体防御学会学術総会  2011.6 

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    Event date: 2011.6 - 2011.7

    Country:Japan  

  • Critical role of DOCK2 in type I IFN induction in plasmacytoid dendriic cells

    K. Gotoh, Y. Tanaka, A. Nishikimi, R. Nakamura, H. Yamada, K. Hoshino, T. Kaisho, Y. Yoshikai, Y. Fukui

    2010.8 

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    Event date: 2010.8

    Country:Japan  

  • CD30 ligand/CD30 play a critical role in Th17 differentiation in mice

    X. Sun, H. Yamada, K. Shibata, H. Muta, K. Tani, E. Podack, Y. Yoshikai

    2010.8 

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    Event date: 2010.8

    Country:Japan  

  • The basic helix-loop-helix protein HES1 controls the differentiation of naturally occurring interleukin (IL)-17-producing γδ T cells

    第14回国際免疫学会 (14th International Congress of Immunology)  2010.8 

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    Event date: 2010.8

    Country:Japan  

  • A protective role of IL-17-producing γδ T cells in lung against systemic candidasis

    第14回国際免疫学会 (14th International Congress of Immunology)  2010.8 

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    Event date: 2010.8

    Country:Japan  

  • Tyk2 is indespensable ofr the development of experimental autoimmune disease

    A. Oyamada, Y. Yoshikai, H. Yamada

    2010.8 

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    Event date: 2010.8

    Country:Japan  

  • Preferential accumulation of Th1 cells in the joints of rheumatoid arthritis and osteoarthritis

    H. Yamada, A. Oyamada, Y. Yoshikai

    2010.8 

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    Event date: 2010.8

    Country:Japan  

  • Interleukin-15 is critical in the pathogenesis of influenza A virus-induced acute lung injury

    R. Nakamura, N. Maeda, O. Noyori, K. Shibata, H. Yamada, Y. Yoshikai

    2010.8 

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    Event date: 2010.8

    Country:Japan  

  • The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury

    H. Saiwai, Y. Ohkawa, H. Yamada, H. Kumamaru, A. Harada, T. Yokomizo, Y. Iwamoto, S. Okada

    2010.8 

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    Event date: 2010.8

    Country:Japan  

  • マウスコラーゲン誘導性関節炎におけるTyk2の重要性

    小山田亜希子、吉開泰信、山田久方

    第21回日本生体防御学会学術総会  2010.7 

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    Event date: 2010.7

    Country:Japan  

  • The basic helix-loop-helix protein HES1は自然発生IL-17産生γδT細胞分化に必要である

    柴田健輔、山田久方、吉開泰信

    第21回日本生体防御学会学術総会  2010.7 

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    Event date: 2010.7

    Country:Japan  

  • インターロイキン-15はインフルエンザAウイルス感染による急性肺障害の病態形成に重要である

    中村梨紗、前田直良、柴田健輔、山田久方、加瀬哲男、吉開泰信

    第21回日本生体防御学会学術総会  2010.7 

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    Event date: 2010.7

    Country:Japan  

  • 関節リウマチ患者における脂質異常

    秋山美緒、馬渡太郎、福士純一、岡崎賢、中島康晴、山田久方、小山田亜希子、岩本幸英

    第83回日本整形外科学会学術集会  2010.5 

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    Event date: 2010.5

    Country:Japan  

  • 関節リウマチ患者における脂質異常

    秋山美緒、馬渡太郎、中島康晴、岡崎賢、福士純一、山田久方、小山田亜希子、岩本幸英

    第54回日本リウマチ学会総会・学術集会  2010.4 

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    Event date: 2010.4

    Country:Japan  

  • マウスコラーゲン誘導性関節炎におけるTyk2の重要性

    小山田亜希子、藤村謙次郎、岩本幸英、吉開泰信、山田久方

    第54回日本リウマチ学会総会・学術集会  2010.4 

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    Event date: 2010.4

    Country:Japan  

  • インフリキシマブによる関節破壊抑制効果の検討

    中島康晴、岡崎賢、馬渡太郎、福士純一、山田久方、田代泰隆、都留智巳、岩本幸英

    第54回日本リウマチ学会総会・学術集会  2010.4 

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    Event date: 2010.4

    Country:Japan  

  • 関節破壊と生物学的製剤の効果 -小関節と加重関節の違い-

    中島康晴、岡崎賢、馬渡太郎、福士純一、田代泰隆、秋山美緒、山田久方、都留智巳、岩本幸英

    第54回日本リウマチ学会総会・学術集会  2010.4 

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    Event date: 2010.4

    Country:Japan  

  • ステロイド性膝骨壊死に伴う関節破壊に対する鏡視下治療の経験

    田代泰隆、三浦裕正、中島康晴、岡崎賢、馬渡太郎、福士純一、山田久方、橋爪誠、岩本幸英

    第39回九州リウマチ学会  2010.3 

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    Event date: 2010.3

    Country:Japan  

  • 関節リウマチ患者における脂質異常

    秋山美緒、馬渡太郎、福士純一、中島康晴、岡崎賢、山田久方、小山田亜希子、岩本幸英

    第39回九州リウマチ学会  2010.3 

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    Event date: 2010.3

    Country:Japan  

  • IL-15は自己抗原特異的CD8陽性T細胞の維持と自然免疫機能に重要である

    山田久方、逸見百江、吉開泰信

    第39回日本免疫学会総会・学術集会  2009.12 

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    Event date: 2009.12

    Country:Japan  

  • 高病原性インフルエンザウイルス(H1N1)感染で誘導される致死的肺傷害病態の解析

    中村梨紗、前田直良、野依修、山田久方、柴田健輔、吉開泰信

    第39回日本免疫学会総会・学術集会  2009.12 

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    Event date: 2009.12

    Country:Japan  

  • BCG膀胱内注入療法の抗腫瘍効果にはgdT細胞によるIL-17産生が重要である

    武内在雄、山田久方、柴田健輔、吉開泰信

    第39回日本免疫学会総会・学術集会  2009.12 

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    Event date: 2009.12

    Country:Japan  

  • CD30 ligand play an important role in development of chronic colitis by modulating T-helper 17 differentiation

    Xun Sun, Hisakata Yamada, Kensuke SHibata, Hiromi Muta, Kenzaburo Tani, Eckhard R Podack, Yoichiro Iwakura, Yasunobu Yoshikai

    2009.12 

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    Event date: 2009.12

    Country:Japan  

  • Tyk2 is indispensable for the development of experimental autoimmune encephalomyelitis and collagen induced arthritis

    2009.12 

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    Event date: 2009.12

    Country:Japan  

  • A protective role of IL-17-producing gd T cells in lung against systemic candidasis

    2009.12 

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    Event date: 2009.12

    Country:Japan  

  • 胸腺におけるIL-17産生γδT細胞転写制御機構の解析

    柴田健輔、山田久方、吉開泰信

    第39回日本免疫学会総会・学術集会  2009.12 

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    Event date: 2009.12

    Country:Japan  

  • IL-15は自己抗原特異的CD8T細胞の維持や機能を制御する

    逸見百江、吉開泰信、山田久方

    第20回日本生体防御学会学術総会  2009.7 

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    Event date: 2009.7

    Venue:東京都   Country:Japan  

  • Th17細胞分化におけるCD30リガンドの役割

    孫遜、山田久方、柴田健輔、牟田浩実、谷憲三朗、Eckhard R. Podack、岩倉洋一郎、吉開泰信

    第20回日本生体防御学会学術総会  2009.7 

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    Event date: 2009.7

    Venue:東京都   Country:Japan  

  • IL-17産生γδT細胞分化に関わる転写制御機構の解析

    柴田健輔、山田久方、吉開泰信

    第20回日本生体防御学会学術総会  2009.7 

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    Event date: 2009.7

    Venue:東京都   Country:Japan  

  • マウス実験性腸炎モデルを用いてのCD30リガンド/CD30の炎症性腸疾患における役割の解明

    孫 遜、山田久方、柴田健輔、牟田浩実、谷憲三朗、Eckhard R. Podack、吉開泰信

    第19回日本生体防御学会学術総会  2008.7 

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    Event date: 2009.7 - 2008.7

    Country:Japan  

  • 関節リウマチの関節内CD4T細胞サブセットの解析

    山田久方、中島康晴、岡崎賢、馬渡太郎、福士純一、小山田亜希子、岩本幸英

    第53回日本リウマチ学会総会・学術集会  2009.4 

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    Event date: 2009.4

    Venue:東京都   Country:Japan  

  • 転写因子C/EBPβは関節炎での様々な炎症誘因反応を調節する多機能因子である

    岡崎賢、林田光正、中島康晴、馬渡太郎、福士純一、山田久方、岩本幸英

    第53回日本リウマチ学会総会・学術集会  2009.4 

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    Event date: 2009.4

    Country:Japan  

  • マウスモデル自己免疫疾患発症におけるTyk2の重要性

    小山田亜希子、岩本幸英、山田久方

    第53回日本リウマチ学会総会・学術集会  2009.4 

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    Event date: 2009.4

    Venue:東京都   Country:Japan  

  • 骨髄由来細胞による自己抗原特異的CD8T細胞の選択的分化

    山田久方、逸見百江、吉開泰信

    第28回日本胸腺研究会  2009.2 

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    Event date: 2009.2

    Country:Japan  

  • CD25陽性IL-17産生γδT細胞は胎児胸線で機能分化を果たす

    柴田健輔, 山田久方, 中村梨沙, 孫遜, 逸見百江, 吉開泰信

    第28回日本胸腺研究会  2009.2 

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    Event date: 2009.2

    Country:Japan  

  • A critical role of IL-15 in acute lung injury induced by influenza virus infection in mice

    MAEDA Naoyoshi, TANG Ce, SHIBATA Kensuke, ITSUMI Momoe, YAMADA Hisakata, KASE Tetsuo, YOSHIKAI Yasunobu

    2008.12 

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    Event date: 2008.12

    Country:Japan  

  • Cyclophosphamide contributes to the antitumor effects of nonmyeloablative allogeneic stem cell transplantation via a reduction of CD4+CD25+Foxp3+ regulatory T cells.

    Ario Takeuchi HisakataYamada Masatoshi Etoh, Yoriyuki Kamiryo, Seiji Naito and Yasunobu Yoshika

    2009.12 

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    Event date: 2008.12

    Country:Japan  

  • CD30L/CD30 signaling by T-T cell interaction augments Th1 responses

    Ce Tang, Hisakata Yamada, Kensuke Shibata, Hiromi Muta, Wajjiwaalku Worawidh, Eckhard R. Podack and Yasunobu Yoshikai

    2008.12 

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    Event date: 2008.12

    Country:Japan  

  • Positive selection of self antigen-specific memory-phenotype CD8 T cells by hematopietic cells

    YAMADA Hisakata, ITSUMI Momoe, and YOSHIKAI Yasunobu

    2008.12 

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    Event date: 2008.12

    Country:Japan  

  • IL-15 regulates development and functions of self antigen-specific memory-phenotype CD8 T cells

    ITSUMI Momoe, YOSHIKAI Yasunobu, YAMADA Hisakata

    2008.12 

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    Event date: 2008.12

    Country:Japan  

  • Tyk2 is indispensable for the development of experimental autoimmune encephalomyelitis

    OYAMADA Akiko, IKEBE Hiori, ITSUMI Momoe, YOSHIKAI Yasunobu, YAMADA Hisakata

    2008.12 

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    Event date: 2008.12

    Country:Japan  

  • Vaccination with dendritic cells overexpressing IL-15 efficiently induced CD8 T cell responses in the absence of CD4 cells

    TERADA Maiko, YAMADA Hisakata, OYAMADA Akiko, YOSHIKAI Yasunobu

    2008.12 

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    Event date: 2008.12

    Country:Japan  

  • Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by γδ T cells.

    第38回日本免疫学会総会・学術総会  2008.12 

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    Event date: 2008.12

    Country:Japan  

  • Identification of CD25+γδT cells as fetal thymus-derived naturally occurring IL-17 producers.

    第38回日本免疫学会総会・学術総会  2008.12 

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    Event date: 2008.12

    Country:Japan  

  • A critical role of CD30 ligand in colitis induced by dextran sulphate sodium in mice

    Xun Sun, Hisakata Yamada, Kensuke Shibata, Hiromi Muta, Kenzaburo Tani, Eckhard R. Podack, and Yasunobu Yoshikai

    2008.12 

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    Event date: 2008.12

    Country:Japan  

  • A protective role of Fas/FasL-mediated signaling in lethal infection with herpes simplex virus type 2 infection in mice

    Takahiro Ishikawa, Hisakata Yamada, Naoyoshi Maeda, Yukihiro Nishiyama, Yasunobu Yoshikai

    2008.12 

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    Event date: 2008.12

    Country:Japan  

  • A protective role of Fas/FasL-mediated signaling in lethal infection with herpes simplex virus type 2 infection in mice

    Takahiro Ishikawa, Hisakata Yamada, Naoyoshi Maeda, Yukihiro Nishiyama, Yasunobu Yoshikai

    2008.12 

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    Event date: 2008.12

    Country:Japan  

  • 関節リウマチの関節内CD4T細胞の解析

    山田久方、中島康晴、岡崎賢、馬渡太郎、福士純一、堀亜希子、岩本幸英

    第23回日本整形外科学会基礎学術総会  2009.10 

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    Event date: 2008.10

    Country:Japan  

  • ヒト関節リウマチにおけるTh17 Invited

    山田久方

    第36回日本臨床免疫学会総会  2008.10 

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    Event date: 2008.10

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 生物学的製剤使用中のリウマチ患者における整形外科手術の検討

    福士純一、中島康晴、岡崎賢、馬渡太郎、岩本幸英、山田久方、小山田亜希子、首藤敏秀、都留智巳

    第36回九州リウマチ学会  2008.9 

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    Event date: 2008.9

    Country:Japan  

  • 実験的自己免疫性脳脊髄炎におけるTyk2の役割

    小山田亜希子、池辺日王里、中山敬一、吉開泰信、山田久方

    第19回日本生体防御学会学術総会  2008.7 

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    Event date: 2008.7

    Country:Japan  

  • IL-17産生γδT細胞はCD25陽性CD122陰性で、胎児胸線で機能分化を果たす

    柴田健輔、山田久方 中村梨沙 孫遜 逸見百恵 吉開泰信

    第19回日本生体防御学会学術総会  2008.7 

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    Event date: 2008.7

    Country:Japan  

  • RAにおける関節予後の検討 ーインフリキシマブとMTX使用例の比較ー

    中島康晴、岡崎賢、馬渡太郎、福士純一、山田久方、堀亜希子、吉澤誠司、都留智巳、首藤敏秀、岩本幸英

    第52回日本リウマチ学会  2008.4 

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    Event date: 2008.4

    Country:Japan  

  • 関節リウマチにおけるIL-17産生T細胞の解析

    山田久方、貝原信孝、堀亜希子、中島康晴、岡崎賢、馬渡太郎、福士純一、岩本幸英

    第51回日本リウマチ学会総会・学術集会  2007.4 

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    Venue:横浜市 平成19年4月26-29日   Country:Japan  

  • 関節リウマチの腱鞘滑膜炎の分子生物学的検討

    貝原信孝、山田久方、中島康晴、岡崎賢、馬渡太郎、福士純一、岩本幸英

    第51回日本リウマチ学会総会・学術集会  2007.4 

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    Venue:横浜市 平成19年4月26-29日   Country:Japan  

  • 膠原病に伴う距骨下関節脱臼の2例

    福士純一、中島康晴、光安廣倫、馬渡太郎、岡崎賢、山田久方、貝原信孝、前田健、岩本幸英

    第51回日本リウマチ学会総会・学術集会  2007.9 

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    Venue:横浜市 平成19年4月26-29日   Country:Japan  

  • 生物学的製剤による加重関節破壊抑制効果の検討

    中島康晴、岡崎賢、馬渡太郎、福士純一、山田久方、貝原信孝、前田健、岩本幸英

    第51回日本リウマチ学会総会・学術集会  2007.4 

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    Venue:横浜市 平成19年4月26-29日   Country:Japan  

  • 関節リウマチの腱鞘滑膜炎の病理学的、分子生物学的検討

    貝原信孝、山田久方、中島康晴、岡崎賢、馬渡太郎、福士純一、堀亜希子、岩本幸英

    第80回日本整形外科学会学術集会  2007.5 

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    Venue:神戸市 平成19年5月24-27日   Country:Japan  

  • Total Larsen scoreを用いたRA加重関節の画像評価

    中島康晴、岡崎賢、馬渡太郎、福士純一、山田久方、堀亜希子、前田健、吉澤誠司、首藤敏秀、岩本幸英

    第34回九州リウマチ学会  2007.9 

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    Venue:北九州市 平成19年9月8-9日   Country:Japan  

  • QCTを用いた骨粗鬆症評価

    馬渡太郎、中島康晴、岡崎賢、福士純一、前田健、首藤敏秀、山田久方、三浦裕正、濱井敏、Keaveny TM、岩本幸英

    第34回九州リウマチ学会  2007.9 

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    Venue:北九州市 平成19年9月8-9日   Country:Japan  

  • 関節リウマチにおけるIL-17産生T細胞の解析

    山田久方、中島康晴、岡崎賢、馬渡太郎、福士純一、岩本幸英

    第22回日本整形外科学会基礎学術集会  2007.10 

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    Venue:浜松市 平成19年10月25-26日   Country:Japan  

  • Identification of IL-17-producing T cells in rheumatoid arthritis

    Hisakata Yamada and Yasunobu Yoshikai

    2007.11 

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    Country:Japan  

  • Critical role of CD30 ligand / CD30 in controlling inflammatory bowel diseases in mice

    Xun Sun, Hisakata Yamada, Kensuke Shibata, Hiromi Muta, Kenzaburo Tani, Eckhard Podack and Yasunobu Yoshikai

    2007.11 

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  • Roles of a novel dual specificity phosphatase, DUSP16, in the development and functions of CD8+ T cells

    Momoe Itsumi, Hisakata Yamada, Tetsuya Matsuguchi, and Yasunobu Yoshikai

    2007.11 

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  • TLR-4-dependent cell surface molecule is required for IL-17 production by γδ T cells in the presence of IL-23

    第37回日本免疫学会  2007.11 

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    Venue:東京都 平成19年11月20-22日   Country:Japan  

  • Soluble branched (1,4)-β-D-glucans from Xanthomonas canpestris enhance antitumor activity against murine malignant melanoma through augmented NK activity and cytotoxic T-cell response

    第37回日本免疫学会  2007.11 

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    Venue:東京都 平成19年11月20-22日   Country:Japan  

  • Tyk2 is indispensable for IL-17 production by peritoneal γδ T cells induced by Escherichia coli infection

    第37回日本免疫学会  2007.11 

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    Venue:東京都 平成19年11月20-22日   Country:Japan  

  • Roles of CD30L in CD4+ and CD8+T cell responses against Mycobacterium bovis Bacillus Calmette-Guérin Infection.

    第37回日本免疫学会  2007.11 

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    Venue:東京都 平成19年11月20-22日   Country:Japan  

  • Roles of CD30 ligand in primary infection with L.monocytogenes

    2007.11 

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  • Tyk2 in IL-23-mediated signaling is indispensable for the development of experimental autoimmune encephalomyelitis.

    Akiko Hori, Hiori Ikebe, Keiichi Nakayama, Yasunobu Yoshikai, and Hisakata Yamada

    2007.11 

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  • 関節リウマチにおけるIL-17産生T細胞の解析 Invited

    山田久方

    第12回リウマチフォーラム  2008.1 

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    Venue:東京都 平成20年1月19-20日   Country:Japan  

  • 生物学的製剤によるRAの関節破壊抑制効果の検討

    中島康晴、岡崎賢、馬渡太郎、福士純一、山田久方、堀亜希子、首藤敏秀、岩本幸英

    第34回九州リウマチ学会  2008.3 

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    Venue:北九州市 平成20年3月15-16日   Country:Japan  

  • Notch-IL-7Ra経路は自然発生IL-17産生γδT細胞分化に必須である

    中村真隆, 柴田 健輔, 山田 久方, 吉開 泰信

    第23回日本生体防御学会学術総会  2012.7 

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    Country:Japan  

  • Notch,γδTCRシグナルによるγδT細胞機能分化制御

    柴田 健輔, 中村真隆, 山田 久方, 吉開 泰信

    第23回日本生体防御学会学術総会  2012.7 

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    Country:Japan  

  • クロレラ熱水抽出物の摂取が健常人の免疫機能に及ぼす影響

    野口直人, 山田 久方, 上野すぎ, 中嶋裕也, 隈本正一郎, 丸山功, 安藤洋太郎, 吉開 泰信

    第23回日本生体防御学会学術総会  2012.7 

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    Country:Japan  

  • Notch-RBP-Jk-IL-7 receptor alpha axis is essential for the maintenance of IL-17 producing γδ T cells

    第41回日本免疫学会総会・学術集会  2012.12 

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    Country:Japan  

  • IL-21 plays an important role in host defence against chronic bacterial infection.

    Risa Nakamura, Yinxia Huang, Yojiro Arimori, Naoya Ohara, HISAKATA YAMADA, Yasunobu Yoshikai

    2012.12 

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    Country:Japan  

  • The critical role of CD30L/CD30 signaling in the pathogenesis of experimental autoimmune encephalomyelitis.

    Koji Shinoda, Xun Sun, HISAKATA YAMADA, Kensuke Shibata, Junnichi Kira, Yasunobu Yoshikai

    2012.12 

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  • IL-21 plays critical roles in the production of pathogenic autoantibody in a murine model of autoimmune arthritis

    HISAKATA YAMADA, Koji Sakuraba, Akiko Oyamada, Risa Nakamura, Kenjiro Fujimura, Yasunobu Yoshikai

    2012.12 

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    Country:Japan  

  • IL-21シグナルはコラーゲン誘導関節炎の発症に重要な役割を果たす

    櫻庭康司, 小山田亜希子, 藤村謙次郎, 橋口智光, 岩本幸英, 吉開 泰信, 山田 久方

    第57回日本リウマチ学会総会・学術集会  2013.4 

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    Country:Japan  

  • CD30 ligand is a target for a novel biological therapy against experimental autoimmune encephalomyelitis

    Koji Shinoda, Xun Sun, Akiko Oyamada, HISAKATA YAMADA, Jun-ichi Kira, Yasunobu Yoshikai

    2013.12 

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  • CD4 T cell tolerance to self type II collagen depends on post-translational modification in the T cell epitope.

    HISAKATA YAMADA, Johan Backlund, Rikard Holmdahl, Yasunobu Yoshikai

    2013.12 

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  • A novel role of CD30L/CD30 signaling by naturally occurring IL-17A-producing γδ T cells in response against mycobacterium bovis BCG.

    第42回日本免疫学会総会・学術集会  2013.12 

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    Country:Japan  

  • Notch-RBP-Jk-IL-7Rα pathway plays a pivotal role in the maintenance of IL-17-producing γδ T cells.

    第42回日本免疫学会総会・学術集会  2013.12 

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  • IL-17-producing γδ T cells develop directly from double-negative 2 cells in murine fetal thymus in Bcl11b-dependent manner.

    第42回日本免疫学会総会・学術集会  2013.12 

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  • Differential requirement of Tyk2 for development of different subsets of CD44high memory phenotype CD4 T cells with Th1 functions.

    Tomomitsu Hashiguchi, Koji Sakuraba, Yasunobu Yoshikai, HISAKATA YAMADA

    2013.12 

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    Country:Japan  

  • Naturally occurring PD-1+ memory phenotype CD8 T cells belong to non-conventonal CD8T cells and are cyclophosphamide-sensitive regulatory T cells.

    Koji Sakuraba, Tomomitsu Hashiguchi,, Yasunobu Yoshikai, HISAKATA YAMADA

    2013.12 

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    Language:English  

    Country:Japan  

  • サルコイドーシスに難治性の膝関節滑膜炎を来たし、鏡視下滑膜切除が奏功した1例

    山田 久方, 田代泰隆, 廣瀬毅, 中島康晴, 岡崎賢, 福士純一, 大石正信, 小山田亜希子, 岩本 幸英

    第58回日本リウマチ学会総会・学術集会  2014.4 

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    Language:Japanese  

    Country:Japan  

  • 関節リウマチ滑膜組織培養法の開発

    山田 久方, 櫻庭康司, 藤村謙次郎, 中島 康晴, 岡崎 賢, 福士 純一, 大石 正信, 田代 泰隆, 小山田 亜希子, 橋口智光, 江崎幸雄, 宮原寿明, 岩本 幸英, 吉開 泰信

    第58回日本リウマチ学会総会・学術集会  2014.4 

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    Language:Japanese  

    Country:Japan  

  • Successful in vitro culture of synovial explants from rheumatoid arthritis at the air-liquid interface.

    2014.12 

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    Language:English  

    Country:Japan  

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MISC

  • 自己反応性CD8T細胞の生存維持とIL-15

    山田 久方

    2012.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • [Th17 cells and human arthritic diseases]

    Yamada H.

    Nihon Rinsho Meneki Gakkai Kaishi. 2010;33(4):214-21.   2010.8

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Current perspectives on the role of IL-17 in autoimmune disease

    Yamada H

    J Inflam Res. 2010 Jun;3:33 - 4   2010.6

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • ヒトのTh17細胞と病態

    山田久方

    細胞工学   2010.3

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  • Th17 cells in human rheumatoid arthritis

    Yamada H

    Nihon Rinsho Meneki Gakkai Kaishi   2009.8

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Th17/IL-17はヒト関節リウマチの病態に関与しているか

    山田久方

    分子リウマチ治療   2009.8

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • IL-17とγδ型Tリンパ球

    柴田 健輔、山田 久方、吉開 泰信

    炎症と免疫   2009.1

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • IL-15

    2008.12

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 感染防御におけるサイトカインの役割

    柴田 健輔、山田 久方、吉開 泰信

    小児科診療   2008.12

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    Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • IL-17A産生γδ 型Tリンパ球の機能

    柴田 健輔、山田 久方、吉開 泰信

    医学のあゆみ   2008.7

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Professional Memberships

  • 日本整形外科学会

  • 九州リウマチ学会

  • 日本リウマチ学会

  • 日本生体防御学会

  • 日本臨床免疫学会

  • 日本免疫学会

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Academic Activities

  • 座長(Chairmanship)

    第58回日本リウマチ学会総会・学術集会  2014.4

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  • 座長(Chairmanship)

    第57回日本リウマチ学会総会・学術集会  2013.4

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第56回日本リウマチ学会総会・学術集会  2012.4

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第55回日本リウマチ学会総会・学術集会  2011.7

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第22回日本生体防御学会学術総会  2011.6 - 2011.7

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第54回日本リウマチ学会総会・学術集会  2010.4

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Research Projects

  • 滑膜常在マクロファージを中心とした関節炎症病態の解析

    Grant number:22K09382  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 悪性骨軟部腫瘍における薬剤耐性獲得機構の解明

    Grant number:25293325  2013 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 関節リウマチにおける自己抗体産生誘導T細胞の解析

    Grant number:24591449  2012 - 2015

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • リウマチ性疾患病態におけるTyrosine kinase 2の機能解析

    2009

    科学研究費助成事業  平成20年度リウマチ性疾患調査・研究助成費

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    Authorship:Principal investigator  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • ILー15による免疫反応制御機構

    Grant number:20591783  2008 - 2010

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • IL-15による免疫反応制御機構

    Grant number:20591783  2008

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 関節炎症性疾患における新規サイトカインレセプターWSX-1の役割

    Grant number:17791008  2005 - 2006

    科学研究費助成事業  若手研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

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Class subject

  • 免疫学

    2013.4 - 2013.9   First semester

  • 感染制御学

    2013.4 - 2013.9   First semester

  • 免疫学

    2012.4 - 2012.9   First semester

  • 感染制御学

    2012.4 - 2012.9   First semester

  • 免疫学

    2011.4 - 2011.9   First semester

  • 感染制御学

    2011.4 - 2011.9   First semester

  • フローサイトメータ

    2010.4 - 2010.9   First semester

  • 免疫学

    2010.4 - 2010.9   First semester

  • 感染制御学

    2010.4 - 2010.9   First semester

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Social Activities

  • ここまで分かった最新のリウマチ免疫異常

    博多リウマチセミナー  福岡市  2013.1

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 関節リウマチの最新の病因論

    名古屋市  2012.3

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 関節炎の免疫学

    日向RA-Meering  日向市  2011.8

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 整形外科医のための免疫学

    日整会教育研修会  福岡市  2011.6

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • いま話題の関節リウマチの病因論

    第11回博多リウマチセミナー  福岡市  2010.1

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 何故DMARDの効果減弱が起こるか?

    博多リウマチセミナー  福岡市  2007.1

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 痛風の最新情報

    博多リウマチセミナー  福岡市  2006.1

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • リウマチの痛みのメカニズム

    博多リウマチセミナー  福岡市  2005.1

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 骨と関節の10年 公開講座

    九州大学整形外科  九大キャンパス  2004.10

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

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Specialized clinical area

  • Biological Sciences / Medicine, Dentistry and Pharmacy / Basic Medicine / Immunology

Clinician qualification

  • Specialist

    Japan College of Rheumatology(JCR)

  • Preceptor

    Japan College of Rheumatology(JCR)

Year of medical license acquisition

  • 1992