Updated on 2025/04/17

Information

 

写真a

 
ASANOMA KAZUO
 
Organization
Faculty of Medical Sciences Associate Professor
Title
Associate Professor
Profile
・Basic research about the differentiation of murine and human trophoblasts ・Basic research about the molecular process of carcinogenesis of uterine endometrial cancer ・Educational activity for doctoral course students ・Medical treatment, surgery ・Educational activity for resident physicians ・Educational activity for internship medical doctors ・Educational activity for medical college students
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Degree

  • MD and PhD

Research Interests・Research Keywords

  • Research theme： Regulation of energy metabolism involved in the epithelial-to-mesenchymal transition of endometrial cancer cells

    Keyword： glycolysis, oxidative phosphorylation, epithelial-to-mesenchymal transition, cell invasion, endometrial cancer

    Research period： 2020.4 - 2024.3

  • Research theme： The mechanism regulating development of endometrial cancer cells by microRNAs

    Keyword： microRNA, endometrial cancer, epithelial-to-mesenchymal transition

    Research period： 2017.4 - 2019.3

  • Research theme： Molecular mechanism involving nuclear matrix associated gene SATB in uterine endometrial carcinogenesis

    Keyword： uterine endometrial cancer, SATB1, SATB2

    Research period： 2013.1 - 2015.3

  • Research theme： Functional analysis of dioxin receptor involved in development of uterine endometrial cancer

    Keyword： aryl hydrocarbon receptor (AHR), uterine endometrial cancer, invasion, proliferation

    Research period： 2011.8 - 2012.8

  • Research theme： Elucidation of a novel mechanism of murine trophoblast stem cell differentiation: involvement of nuclear matrix associated molecules, Satb

    Keyword： murine trophoblast stem cell, differentiation

    Research period： 2011.4 - 2014.3

  • Research theme： Establishment of rat placenta trophoblast stem cell lines

    Keyword： rat, placenta, trophoblast stem cells

    Research period： 2007.9 - 2010.12

  • Research theme： Homeobox gene HOPX is epigenetically silenced in human uterine endometrial cancer and suppresses estrogen-stimulated proliferation of cancer cells by inhibiting serum response factor

    Keyword： uterine endometrial cancer, NECC1, SRF, c-fos

    Research period： 2005.7 - 2008.12

  • Research theme： HOP/NECC1, a novel regulator of mouse trophoblast differentiation

    Keyword： placenta, trophoblast, differentiation

    Research period： 2003.1 - 2007.6

  • Research theme： 絨毛癌抑制遺伝子の単離

    Keyword： 絨毛癌、癌抑制遺伝子

    Research period： 1998.4 - 2002.12

Papers

  • Mutual suppression between BHLHE40/BHLHE41 and the MIR301B-MIR130B cluster is involved in epithelial-to-mesenchymal transition of endometrial cancer cells Reviewed

    Kazuo Asanoma, Emiko Hori, Sachiko Yoshida, Hiroshi Yagi, Ichiro Onoyama, Keisuke Kodama, Masafumi Yasunaga, Tatsuhiro Ohgami, Eisuke Kaneki, Kaoru Okugawa, Hideaki Yahata, Kiyoko Kato

    Oncotarget   10 ( 45 )   4640 - 4654   2019.7

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    BHLHE40 and BHLHE41 (BHLHE40/41) are basic helix-loop-helix type transcription factors involved in multiple cell activities including epithelial-to-mesenchymal transition (EMT). However, the expression mechanism of BHLHE40/41 in EMT remains unclear. In the present study, we showed that the expression levels of BHLHE40/41 were negatively correlated with those of the microRNA (MIR) 130 family in endometrial cancer (EC) specimens. Our in vitro assays indicated that the expression of BHLHE40/41 was suppressed directly by the MIR130 family in a 3'-untranslated region-mediated manner. In EC cells, the MIR130 family promoted EMT and tumor cell invasion by suppressing the expression of BHLHE40/41. We identified the critical promoter region of the MIR301B-MIR130B cluster for its basal transcription by the transcription factor, SP1. We also found that BHLHE40/41 suppressed the expression of MIR301B and MIR130B, and we identified a binding site in the promoter region for BHLHE40/41. This study is the first to report that BHLHE40/41 and the MIR301B-MIR130B cluster suppressed each other to regulate EMT and invasion of EC cells. We propose that BHLHE40/41 and the MIR130 family are excellent markers to predict the progression of EC cases, and that molecular therapy targeting the MIR130 family-BHLHE40/41 axis may effectively control EC extension.

    DOI： 10.18632/oncotarget.27061

  • Regulation of the Mechanism of TWIST1 Transcription by BHLHE40 and BHLHE41 in Cancer Cells

    KAZUO ASANOMA, Ge Liu, Takako Yamane, Yoko Miyanari, Tomoka Takao, Hiroshi Yagi, Tatsuhiro Ohgami, AKIMASA ICHINOE, Kenzo Sonoda, Norio Wake, Kiyoko Kato

    MOLECULAR AND CELLULAR BIOLOGY   35 ( 24 )   2015.12

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    DOI： 10.1128/MCB.00678-15

  • Inhibition of AHR transcription by NF1C is affected by a single nucleotide polymorphism, and is involved in suppression of human uterine endometrial cancer Reviewed International journal

    Dan Li, Tomoka Takao, Ryosuke TSUNEMATSU, Seiichi Morokuma, Kotaro Fukushima, Hiroaki Kobayashi, Toshiaki Saito, Masutaka Furue, Norio Wake, KAZUO ASANOMA

    Oncogene   30   4950 - 4959   2013.10

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    Involvement of the aryl hydrocarbon receptor (AHR) in carcinogenesis has been suggested in many studies. Upregulation of AHR has been reported in some cancer species, and an association between single-nucleotide polymorphisms (SNPs) of AHR and cancer risk or cancer development has also been reported. This evidence suggests the involvement of some specific SNPs in AHR transcriptional regulation in the process of carcinogenesis or cancer development, but there have been no studies to elucidate the mechanism involved. In this study, we identified the transcription factor Nuclear Factor 1-C (NF1C) as a candidate to regulate AHR transcription in a polymorphism-dependent manner. SNP rs10249788 was included in a consensus binding site for NF1C. Our results suggested that NF1C preferred the C allele to the T allele at rs10249788 for binding. Forced expression of NF1C suppressed the activity of the AHR promoter with C at rs10249788 stronger than that with T. Moreover, expression analysis of human uterine endometrial cancer (HEC) specimens showed greater upregulation of AHR and downregulation of NF1C than those of normal endometrium specimens. Sequence analysis showed HEC patients at advanced stages tended to possess T/T alleles more frequently than healthy women. We also demonstrated that NF1C suppressed proliferation, motility and invasion of HEC cells. This function was at least partially mediated by AHR. This study is the first to report that a polymorphism on the AHR regulatory region affected transcriptional regulation of the AHR gene in vitro. Because NF1C is a tumor suppressor, our new insights into AHR deregulation and its polymorphisms could reveal novel mechanisms of genetic susceptibility to cancer.

  • SATB homeobox proteins regulate trophoblast stem cell renewal and differentiation. Reviewed International journal

    Asanoma K, Kubota K, Chakraborty D, Renaud SJ, Wake N, Fukushima K, Soares MJ, Rumi MA.

    Journal of Biological Chemistry   287 ( 3 )   2012.1

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  • FGF4-dependent stem cells derived from rat blastocysts differentiate along the trophoblast lineage. Reviewed International journal

    Asanoma K, Rumi MA, Kent LN, Chakraborty D, Renaud SJ, Wake N, Lee DS, Kubota K, Soares MJ

    Developmental Biology   351 ( 1 )   2011.3

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  • HOPX is epigenetically silenced in human uterine endometrial cancer and suppresses estrogen-stimulated proliferation of cancer cells by inhibiting serum response factor. Reviewed International journal

    *Yamaguchi S, *Asanoma K, Takao T, Kato K, Wake N

    International Journal of Cancer   124 ( 11 )   2009.6

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  • HOP/NECC1, A Novel Regulator of Mouse Trophoblast Differentiation Reviewed International journal

    Asanoma K., Kato H., Yamaguchi S., Shin C. H., Liu Z. P. Kato K., Inoue T., Miyanari Y., Yoshikawa K., Sonoda K., Fukushima K. and Wake N

    Journal of Biological Chemistry   282 ( 33 )   2007.7

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  • NECC1, a candidate choriocarcinoma suppressor gene which encodes homeodomain consensus motif. Reviewed International journal

    Asanoma K, Matsuda T, Kondo H, Kato K, Kishino T, Niikawa N, Wake N, Kato H

    Genomics   81 ( 1 )   15 - 25   2003.1

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    DOI： 10.1016/S0888-7543(02)00011-3

  • Prognostic outcomes and risk factors for recurrence after laser vaporization for cervical intraepithelial neoplasia: a single-center retrospective study. Reviewed International journal

    Kodama Keisuke, Yahata Hidenori, Okugawa Kaoru, Tomonobe Hiroshi, Yasutake Nobuko, Yoshida Sachiko, Yagi Hiroshi, Yasunaga Masafumi, Ohgami Tatsuhiro, Onoyama Ichiro, Asanoma Kazuo, Hori Emiko, Shimokawa Mototsugu, Kato Kiyoko

    International Journal of Clinical Oncology   26 ( 4 )   770 - 776   2021.4

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    DOI： 10.1007/s10147-020-01848-x

  • Hypersensitivity reaction to pegylated liposomal doxorubicin administration for Mullerian carcinoma in Japanese women. Reviewed International journal

    Yamaguchi Shinichiro, Yahata Hideaki, Okugawa Kaoru, Kodama Keisuke, Yagi Hiroshi, Yasunaga Masafumi, Ohgami Tatsuhiro, Onoyama Ichiro, Asanoma Kazuo, Kato Kiyoko

    Journal of Obstetrics and Gynaecology Research   47 ( 4 )   1544 - 1548   2021.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/jog.14680

  • Prognostic impact of the subclassification of Müllerian cancer stage IV in the FIGO 2014 staging system with a focus of extra-abdominal lymph node metastases. Reviewed International journal

    Yasunaga Masafumi, Yahata Hideaki, Okugawa Kaoru, Hori Emiko, Kodama Keisuke, Yagi Hiroshi, Ohgami Tatsuhiro, Onoyama Ichiro, Asanoma Kazuo, Kato Kiyoko

    International Journal of Clinical Oncology   2021.3

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    DOI： 10.1007/s10147-021-01908-w

  • YBX2 and cancer testis antigen 45 contribute to stemness, chemoresistance and a high degree of malignancy in human endometrial cancer. Invited Reviewed International journal

    Suzuki Izumi, Yoshida Sachiko, Tabu Kouichi, Kusunoki Soshi, Matsumura Yumiko, Izumi Hiroto, Asanoma Kazuo, Yagi Hiroshi, Onoyama Ichiro, Sonoda Kenzo, Kohno Kimitoshi, Taga Tetsuya, Itakura Atsuo, Takeda Satoru, *Kato Kato

    Scientific Reports   11 ( 1 )   2021.2

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    DOI： 10.1038/s41598-021-83200-5

  • Fibronectin mediates activation of stromal fibroblasts by SPARC in endometrial cancer cells. Invited Reviewed International journal

    Yoshida Sachiko, Asanoma Kazuo, Yagi Hiroshi, Onoyama Ichiro, Hori Emiko, Matsumura Yumiko, Okugawa Kaoru, Yahata Hideaki, Kato Kiyoko

    BMC Cancer   21 ( 1 )   2021.2

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    DOI： 10.1186/s12885-021-07875-9

  • Identification of genes associated with endometrial cell ageing. Reviewed International journal

    Kawamura Teruhiko, Tomari Hiroyuki, Onoyama Ichiro, Araki Hiromitsu, Yasunaga Masafumi, Lin Cui, Kawamura Keiko, Yokota Natsuko, Yoshida Sachiko, Yagi Hiroshi, Asanoma Kazuo, Sonoda Kenzo, Egashira Katsuko, Ito Takahiro, Kato Kiyoko

    Molecular Human Reproduction   27 ( 2 )   2021.2

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    DOI： 10.1093/molehr/gaaa078

  • Evaluation of adjuvant chemotherapy after abdominal trachelectomy for cervical cancer: a single-institution experience. Reviewed International journal

    Okugawa Kaoru, Yahata Hideaki, Sonoda Kenzo, Kodama Keisuke, Yagi Hiroshi, Ohgami Tatsuhiro, Yasunaga Masafumi, Onoyama Ichiro, Kaneki Eisuke, Asanoma Kazuo, Kobayashi Hirosaki, Kato Kiyoko

    International Journal of Clinical Oncology   26 ( 1 )   216 - 224   2021.1

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    DOI： 10.1007/s10147-020-01778-8

  • Downregulation of 5-hydroxymethylcytosine is associated with the progression of cervical intraepithelial neoplasia. Reviewed International journal

    Kato Masaya, Onoyama Ichiro, Kawakami Minoru, Yoshida Sachiko, Kawamura Keiko, Kodama Keisuke, Hori Emiko, Cui Lin, Matsumura Yumiko, Yagi Hiroshi, Asanoma Kazuo, Yahata Hideaki, Itakura Atsuo, Takeda Satoru, Kato Kiyoko

    PLoS One   2020.11

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    DOI： 10.1371/journal.pone.0241482

  • Dual-specificity phosphatase 6 plays a critical role in the maintenance of a cancer stem-like cell phenotype in human endometrial cancer. Reviewed International journal

    Kato Masaya, Onoyama Ichiro, Yoshida Sachiko, Cui Lin, Kawamura Keiko, Kodama Keisuke, Hori Emiko, Matsumura Yumiko, Yagi Hiroshi, Asanoma Kazuo, Yahata Hideaki, Itakura Atsuo, Takeda Satoru, Kato Kiyoko

    International Journal of Cancer   147 ( 7 )   1987 - 1999   2020.10

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    DOI： 10.1002/ijc.32965

  • Is Adjuvant Therapy Necessary for Patients with Intermediate-Risk Cervical Cancer after Open Radical Hysterectomy? Invited Reviewed International journal

    Yahata Hideaki, Sonoda Kenzo, Inoue Shusaku, Yasutake Nobuko, Kodama Keisuke, Yagi Hiroshi, Yasunaga Masafumi, Ohgami Tatsuhiro, Onoyama Ichiro, Kaneki Eisuke, Okugawa Kaoru, Asanoma Kazuo, Kato Kiyoko

    Oncology   98 ( 12 )   853 - 858   2020.7

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    DOI： 10.1159/000508569

  • Contribution of senescence in human endometrial stromal cells during proliferative phase to embryo receptivity. Reviewed International journal

    Tomari Hiroyuki, Kawamura Teruhiko, Asanoma Kazuo, Egashira Katsuko, Kawamura Keiko, Honjo Ko, Nagata Yumi, Kato Kiyoko

    Biology of Reproduction   103 ( 1 )   104 - 113   2020.6

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    DOI： 10.1093/biolre/ioaa044

  • Gα13-mediated LATS1 down-regulation contributes to epithelial-mesenchymal transition in ovarian cancer. Reviewed International journal

    Yagi Hiroshi, Onoyama Ichiro, Asanoma Kazuo, Hori Emiko, Yasunaga Masafumi, Kodama Keisuke, Kijima Masako, Ohgami Tatsuhiro, Kaneki Eisuke, Okugawa Kaoru, Yahata Hideaki, Kato Kiyoko

    FASEB Journal   33 ( 12 )   13683 - 13694   2019.12

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    DOI： 10.1096/fj.201901278R

  • Survey of the desire to have children and engage in sexual activity after trachelectomy among young Japanese women with early-stage cervical cancer Reviewed

    Hideaki Yahata, Kenzo Sonoda, Kaoru Okugawa, Hiroshi Yagi, Tatsuhiro Ohgami, Masafumi Yasunaga, Ichiro Onoyama, Eisuke Kaneki, Kazuo Asanoma, Kiyoko Kato

    Journal of Obstetrics and Gynaecology Research   45 ( 11 )   2255 - 2259   2019.11

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    Aim: To evaluate how the desire to have children and engage in sexual activity change after trachelectomy in Japanese women with early-stage cervical cancer who strongly desired to have children before surgery. Methods: Desire to have children, coital pain, fear of sexual intercourse, sexual activity frequency and libido were assessed in cervical cancer patients who received follow-up after trachelectomy. An anonymous questionnaire survey was conducted via informed consent. Results: Of the 151 patients who underwent trachelectomy at Kyushu University Hospital between 2005 and 2015, 46 patients were evaluated; the response rate was 30%. The desire to have children disappeared in 13 of 46 (28%) patients, and 14 (30%) patients experienced increased coital pain. Moreover, 19 (41%) patients experienced fear of sexual intercourse, and sexual frequency decreased in 24 (52%) patients. Conclusion: Trachelectomy is an important fertility-sparing surgical method; however, this study revealed loss of the desire to have children and/or to engage in sexual activity in some patients after surgery. Counseling about these issues is important and should be addressed.

    DOI： 10.1111/jog.14099

  • Fibrosis in Preeclamptic Placentas Is Associated with Stromal Fibroblasts Activated by the Transforming Growth Factor-β1 Signaling Pathway Reviewed

    Takako Ohmaru-Nakanishi, Kazuo Asanoma, Mai Fujikawa, Yasuyuki Fujita, Hiroshi Yagi, Ichiro Onoyama, Nobuhiro Hidaka, Kenzo Sonoda, Kiyoko Kato

    American Journal of Pathology   188 ( 3 )   683 - 695   2018.3

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    Although fibrosis is one of the most prominent pathologic features of preeclamptic (PE) placentas, its mechanism remains largely unknown. Consistent with previous reports, we observed overexpression of collagen; actin, α2, smooth muscle, aorta; connective tissue growth factor; and fibronectin in PE placentas compared with control ones. To investigate the mechanism of fibrosis in PE placentas, placental fibroblasts were isolated from PE placentas or normal pregnancies at delivery. The expression of fibrosis-related factors in fibroblasts was evaluated by real-time RT-PCR, Western blotting, enzyme-linked immunosorbent assay, and gene microarrays. An in vitro collagen gel contraction assay was also performed. Fibroblasts isolated from PE placentas showed higher expression levels of fibrosis-related factors compared with those from control ones. Global gene expression profiling of PE fibroblasts was contrasted with that of control ones and indicated an intimate association with transforming growth factor-β1 (TGFB1) signaling. Furthermore, the PE fibroblasts expressed abundant phosphorylated SMAD family member 2 and showed higher expression levels of target genes of TGFB1 signaling compared with the control ones. The PE fibroblasts also had a greater ability to contract compared with the control ones. Contractility also depended on TGFB1 signaling. Our results suggest that TGFB1 signaling is activated in the fibroblasts in PE placentas and that these active fibroblasts contribute to fibrosis.

    DOI： 10.1016/j.ajpath.2017.11.008

  • FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors Reviewed

    Shoko Kitade, Ichiro Onoyama, Hiroaki Kobayashi, Hiroshi Yagi, Sachiko Yoshida, Masaya Kato, Ryosuke Tsunematsu, Kazuo Asanoma, Kenzo Sonoda, Norio Wake, Kenichiro Hata, Keiichi I. Nakayama, Kiyoko Kato

    Cancer Science   107 ( 10 )   1399 - 1405   2016.10

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    FBXW7 is a ubiquitin ligase that mediates ubiquitylation of oncoproteins, such as c-Myc, cyclin E, Notch and c-Jun. FBXW7 is a known tumor-suppressor gene, and mutations in FBXW7 have been reported in various human malignancies. In this study, we examined the sequences of the FBXW7 and p53 genes in 57 ovarian cancer clinical samples. Interestingly, we found no FBXW7 mutations associated with amino acid changes. We also investigated FBXW7 expression levels in 126 epithelial ovarian tumors. FBXW7 expression was negatively correlated with the malignant potential of ovarian tumors. That is to say, FBXW7 expression levels in ovarian cancer samples were significantly lower than those in borderline and benign tumors (P < 0.01). FBXW7 expression levels in serous carcinoma samples were the lowest among four major histological subtypes. In addition, p53-mutated ovarian cancer samples showed significantly lower levels of FBXW7 expression compared with p53 wild-type cancer samples (P < 0.001). DNA methylation arrays and bisulfite PCR sequencing experiments revealed that 5′-upstream regions of FBXW7 gene in p53-mutated samples were significantly higher methylated compared with those in p53 wild-type samples (P < 0.01). This data indicates that p53 mutations might suppress FBXW7 expression through DNA hypermethylation of FBXW7 5′-upstream regions. Thus, FBXW7 expression was downregulated in ovarian cancers, and was associated with p53 mutations and the DNA methylation status of the 5′-upstream regions of FBXW7.

    DOI： 10.1111/cas.13026

  • GEP oncogene promotes cell proliferation through YAP activation in ovarian cancer Reviewed

    H. Yagi, K. Asanoma, T. Ohgami, A. Ichinoe, K. Sonoda, K. Kato

    Oncogene   35 ( 34 )   4471 - 4480   2016.8

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    G-protein-coupled receptors (GPCRs) and their ligands function in the progression of human malignancies. G12 and G13, encoded by GNA12 and GNA13, respectively, are referred to as the GEP oncogene and are implicated in tumor progression. However, the molecular mechanisms by which G12/13 activation promotes cancer progression are not fully elucidated. Here, we demonstrate elevated expression of G12/13 in human ovarian cancer tissues. G12/13 activation did not promote cellular migration in the ovarian cancer cell lines examined. Rather, G12/13 activation promoted cell growth. We used a synthetic biology approach using chimeric G proteins and GPCRs activated solely by artificial ligands to selectively trigger signaling pathways downstream of specific G proteins. We found that G12/13 promotes proliferation of ovarian cancer cells by activating the transcriptional coactivator YAP, a critical component of the Hippo signaling pathway. Furthermore, we reveal that inhibition of YAP by short hairpin RNA or a specific inhibitor prevented the growth of ovarian cancer cells. Therefore, YAP may be a suitable therapeutic target in ovarian cancer.

    DOI： 10.1038/onc.2015.505

  • Identification of the critical site of calponin 1 for suppression of ovarian cancer properties Reviewed

    Takako Yamane, Kazuo Asanoma, Hiroaki Kobayashi, Ge Liu, Hiroshi Yagi, Tatsuhiro Ohgami, Akimasa Ichinoe, Kenzo Sonoda, Norio Wake, Kiyoko Kato

    Anticancer research   35 ( 11 )   5993 - 5999   2015.11

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    Background: Although several studies have demonstrated the tumor suppressive function of CNN1 (calponin 1), no studies have performed a site-specific analysis of CNN1 on tumor cell activities. Materials and Methods: We herein studied the site-specific effects of CNN1 in ovarian cancer cells using full-length CNN1 (fCNN1), three CNN1 repeats (3CNRs), or the first CNN1 repeat (CNR1) expression vectors. Ovarian cancer cells stably expressing each construct were analyzed for in vitro proliferation, cell motility, invasion, and soft agar assays. An in vitro model of pleural dissemination was also established. Results: Cell proliferation, anchorageindependent colony formation, cell motility, and cell invasion were all suppressed in fCNN1, 3CNRs, and CNR1-stably-expressing cells. CNN1 expression in mesothelial cells suppressed cancer cell invasion into a monolayer of mesothelial cells. Conclusion: CNR1 showed similar suppressive effects as fCNN1. Results suggest CNR1 as a potential small synthetic peptide candidate for therapeutic strategies against ovarian cancer.

  • SNP55, a new functional polymorphism of MDM2-P2 promoter, contributes to allele-specific expression of MDM2 in endometrial cancers Reviewed

    Kanako Okamoto, Ryosuke Tsunematsu, Tomoko Tahira, Kenzo Sonoda, Kazuo Asanoma, Hiroshi Yagi, Tomoko Yoneda, Kenshi Hayashi, Norio Wake, Kiyoko Kato

    BMC Medical Genetics   16 ( 1 )   2015.8

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    Background: The functional single nucleotide polymorphism (SNP) in the MDM2 promoter region, SNP309, is known to be associated with various diseases, particularly cancer. Although many studies have been performed to demonstrate the mechanism of allele-specific expression (ASE) on SNP309, they have only utilized in vitro techniques. It is unknown whether ASE of MDM2 is ascribed solely to SNP309, in vivo. Methods: We attempted to evaluate ASE of MDM2 in vivo using post-labeling followed by automated capillary electrophoresis under single-strand conformation polymorphism conditions. For measuring a quantitative difference, we utilized the SNPs on the exons of MDM2 as markers, the status of which was heterozygous in a large population. To address the cause of ASE beyond 20 %, we confirmed sequences of both MDM2-3'UTR and promoter regions. We assessed the SNP which might be the cause of ASE using biomolecular interaction analysis and luciferase assay. Results: ASE beyond 20 % was detected in endometrial cancers, but not in cancer-free endometria samples only when an SNP rs1690916 was used as a marker. We suspected that this ASE in endometrial cancer was caused by the sequence heterogeneity in the MDM2-P2 promoter, and found a new functional polymorphism, which we labelled SNP55. There was no difference between cancer-free endometria and endometrial cancer samples neither for SNP55 genotype frequencies nor allele frequencies, and so, SNP55 alone does not affect endometrial cancer risk. The SNP55 status affected the DNA binding affinity of transcription factor Sp1 and nuclear factor kappa-B (NFκB). Transcriptional activity of the P2 promoter containing SNP55C was suppressed by NFκB p50 homodimers, but that of SNP55T was not. Only ASE-positive endometrial cancer samples displayed nuclear localization of NFκB p50. Conclusions: Our findings suggest that both the SNP55 status and the NFκB p50 activity are important in the transcriptional regulation of MDM2 in endometrial cancers.

    DOI： 10.1186/s12881-015-0216-8

  • Aryl hydrocarbon receptor SNP-130 C/T associates with dioxins susceptibility through regulating its receptor activity and downstream effectors including interleukin 24

    Ge Liu, KAZUO ASANOMA, Tomoka Takao, Kiyomi Tsukimori, Uchi Hiroshi, Masutaka Furue, Kiyoko Kato, Norio Wake

    TOXICOLOGY LETTERS   232 ( 2 )   2015.1

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    DOI： 10.1016/j.toxlet.2014.11.025

  • The maternally expressed gene Tssc3 regulates the expression of MASH2 transcription factor in mouse trophoblast stem cells through the AKT-Sp1 signaling pathway. Reviewed International journal

    Tomoka Takao, KAZUO ASANOMA, Ryosuke TSUNEMATSU, Kiyoko Kato, Norio Wake

    Journal of Biological Chemistry   287 ( 51 )   42685 - 42694   2012.12

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    Tssc3 is a maternally expressed/paternally silenced imprinted gene. Recent evidence suggests that the loss of TSSC3 results in placental overgrowth in mice. These findings showed that the TSSC3 gene functions as a negative regulator of placental growth. In this study, we describe the function of TSSC3 and its signaling pathway in mouse trophoblast stem (TS) cell differentiation. First of all, we tested Tssc3 expression levels in TS cells. TS cells expressed Tssc3, and its expression level was the highest from day 1 to 4 but was down-regulated at day 5 after the induction of differentiation. Overexpression of TSSC3 in TS cells up-regulated Gcm1 and Mash2, which are marker genes of mouse trophoblast differentiation. Down-regulation of TSSC3 by siRNA enhanced Pl1 and Tpbpa expression in TS cells cultured under stem cell conditions, suggesting the contribution of TSSC3 to the differentiation from TS to trophoblast progenitors and/or labyrinth trophoblasts. TSSC3 activated the PI3K/AKT pathway through binding with phosphatidylinositol phosphate lipids and enhanced the activity of a promoter containing an E-box structure, which is the binding sequence of the Mash2 downstream target gene promoter. PI3K inhibitor suppressed the promoter activity induced by TSSC3. TSSC3 induced Sp1 translocation from cytoplasm to nucleus through the PI3K/AKT pathway. Nuclear Sp1 activated the Mash2 transcription by Sp1 binding with a consensus Sp1-binding motif. This is the first report describing that TSSC3 plays an important role in the differentiation from TS to trophoblast progenitors and/or labyrinth trophoblasts through the TSSC3/PI3K/AKT/MASH2 signaling pathway.

    DOI： 10.1074/jbc.M112.388777

  • Isolation and characterization of human trophoblast side-population (SP) cells in primary villous cytotrophoblasts and HTR-8/SVneo cell line. Reviewed International journal

    Takao T, Asanoma K, Kato K, Fukushima K, Tsunematsu R, Hirakawa T, Matsumura S, Seki H, Takeda S, Wake N

    PLosOne   6 ( 7 )   2011.7

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  • Chromosome-substituted rat strains provide insights into the genetics of placentation. Reviewed International journal

    Konno T, Rempel LA, Rumi MA, Graham AR, Asanoma K, Renaud SJ, Soares MJ.

    Physiolocgical Genomics   43 ( 15 )   2011.6

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  • Level of reactive oxygen species induced by p21Waf1/CIP1 is critical for the determination of cell fate. Reviewed International journal

    Inoue T, Kato K, Kato H, Asanoma K, Kuboyama A, Ueoka Y, Yamaguchi S, Ohgami T, Wake N

    Cancer Science   100 ( 7 )   2010.2

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  • Endometrial cancer side-population cells show prominent migration and have a potential to differentiate into the mesenchymal cell lineage. Reviewed International journal

    Kato K, Takao T, Kuboyama A, Tanaka Y, Ohgami T, Yamaguchi S, Adachi S, Yoneda T, Ueoka Y, Kato K, Hayashi S, Asanoma K, Wake N

    American Journal of Pathology   176 ( 1 )   2010.2

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  • Medroxyprogesterone acetate inhibits proliferation of colon cancer cell lines by modulating cell cycle-related protein expression Reviewed International journal

    Tanaka Y, Kato K, Mibu R, Uchida S, Asanoma K, Hashimoto K, Nozaki M, Wake N

    Menopause   15 ( 3 )   2008.2

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Hypoxia inducible factor 1 alpha regulates matrigel-induced endovascular differentiation under normoxia in a human extravillous trophoblast cell line. Reviewed International journal

    Fukushima K, Murata M, Hachisuga M, Tsukimori K, Seki H, Takeda S, Asanoma K, Wake N

    Placenta   29 ( 4 )   2008.2

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Characterization of side-population cells in human normal endometrium. Reviewed International journal

    Kato K, Yoshimoto M, Kato K, Adachi S, Yamayoshi A, Arima T, Asanoma K, Kyo S, Nakahatat T, Wake N

    Human Reproduction   22 ( 5 )   2007.5

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    Language：English   Publishing type：Research paper (scientific journal)  

  • An inhibitory effect on cell proliferation by blockage of the MAPK/estrogen receptor/MDM2 signal pathway in gynecologic cancer. Reviewed International journal

    Suga S, Kato K, Ohgami T, Yamayoshi A, Adachi S, Asanoma K, Yamaguchi S, Arima T, Kinoshita K, Wake N

    Gycecologic Oncology   105 ( 2 )   2006.5

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Induction of human endometrial cancer cell senescence through modulation of HIF-alpha activity by EGLN1. Reviewed International journal

    Kato H., Inoue T., Asanoma K., Nishimura C., Matsuda T. and Wake N.

    International Journal of Cancer   118 ( 5 )   2006.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Activation of STAT3/5 signal pathways in complete mole and repression in choriocarcinoma cell lines. Reviewed International journal

    Kato H, Inoue T, Asanoma K, Matsuda T, Yoshikawa Y, Wake N

    Journal of Reproductive Medicine   51 ( 1 )   2006.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Differential Diagnosis Between Complete and Partial Mole by TSSC3 Antibody Completely Correlates to DNA Diagnosis. Reviewed International journal

    Kato, H., Matsuda, T., Hirakawa, T., Ueda, K., Inoue, T., Miyanari, Y., Asanoma, K., Nakano, H. and Wake, N.

    Diagn. Mol. Pathol.   14 ( 3 )   164 - 169   2005.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/01.pas.0000162757.91649.a3

  • Analysis of a candidate gene associated with growth suppression of choriocarcinoma and differentiation of trophoblasts. Invited International journal

    Asanoma K, Kato H, Inoue T, Matsuda T, Wake N

    Journal of Reproductive Medicine   49 ( 8 )   617 - 626   2004.8

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    Language：English   Publishing type：Research paper (international conference proceedings)  

  • Expression of DCC and netrin-1 in normal human endometrium and its implication in endometrial carcinogenesis. Reviewed International journal

    Kato, H.D., Kondoh, H., Inoue, T., Asanoma, K., Matsuda, T., Arima, T., Kato, K., Yoshikawa, T. and Wake, N.

    Gynecol. Oncol.   95 ( 2 )   281 - 289   2004.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ygyno.2004.07.050

  • Identification of FOXC1 as a TGF-β1 responsive gene and its involvement in negative regulation of cell growth. Reviewed International journal

    Zhou Y, Kato H, Asanoma K, Kondo H, Arima T, Kato K, Matsuda T, Wake N

    Genomics   80 ( 5 )   465 - 472   2002.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1006/geno.2002.6860

  • Suppressed tumorigenicity of human endometrial cancer cells by the restored expression of DCC gene. Reviewed International journal

    Kato H, Zhou Y, Asanoma K, Kondo H, Yoshikawa Y, Watanabe K, Matsuda T, Wake N and Barrett JC

    British Journal of Cancer   82 ( 2 )   459 - 466   2000.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1054/bjoc.1999.0943

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Books

  • 胎盤の基礎と診療・絨毛細胞の分化機構

    福嶋恒太郎、浅野間和夫、和氣徳夫（Role：Joint author）

    産科と婦人科  2011.6 

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    Responsible for pages：巻:７４ 号:７ 頁:775-781   Language：Japanese   Book type：Scholarly book

  • 絨毛癌の分子機構

    浅野間和夫、松田貴雄、和氣徳夫（Role：Edit）

    中山書店  2002.1 

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    Responsible for pages：41巻423-432ページ   Language：Japanese   Book type：Scholarly book

Presentations

  • BHLHE40 regulates glycolysis and oxidative phosphorylation in endometrial cancer cells.

    Asanoma Kazuo, Yagi Hiroshi, Onoyama Ichiro, Yoshida Sacihko, Kodama Keisuke, Kawakami Minoru, Tomonobe Hiroshi, Yasutake Nobuko, Yasunaga Masafumi, Ohgami Tatsuhiro, Okugawa Kaoru, Yahata Hideaki, Kato Kiyoko

    第73回日本産科婦人科学会学術講演会  2021.4 

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    Event date： 2021.5

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：新潟   Country：Japan  

  • Regulation of trophoblast differentiation by nuclear matrix associated gene, Satb1 and Satb2 International conference

    Asanoma Kazuo, Kubota Kaiyu, Chakraborty Damayanti, Stephen J. Renaud, Wake Norio, Kotaro Fukushima, Michael J. Soares, M. A. Karim Rumi

    International Federation of Placenta Association Meeting 2012  2012.9 

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    Event date： 2021.5

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Hiroshima   Country：Japan  

  • Transcriptional factors, DEC1 and DEC2 cooperatively regulate epithelial-to-mesenchymal transition of uterine endometrial cancer cells.

    Kazuo Asanoma, Hiroaki Kobayashi, Norio Wake, Kiyoko Kato.

    第66回日本産科婦人科学会学術講演会  2014.4 

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    Event date： 2021.5

    Language：English   Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

  • Basic HLH type of transcriptional factors, DEC1 and DEC2 suppress epithelial-to-mesenchymal transition of uterine endometrial cancer cells.

    Kazuo Asanoma, Takako Yamane, Kenzo Sonoda, Norio Wake, Kiyoko Kato

    第67回日本産科婦人科学会学術講演会  2015.4 

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    Event date： 2021.5

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Basic HLH type of transcriptional factors, BHLHE40 and BHLHE41 suppress epithelial-to-mesenchymal transition of endometrial cancer cells by inhibiting SP1 function.

    Kazuo Asanoma, Takako Ohmaru, Kenzo Sonoda, Norio Wake, Kiyoko Kato

    第68回日本産科婦人科学会学術講演会  2016.4 

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    Event date： 2021.5

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • BHLHE40 and BHLHE41 suppress epithelial-to-mesenchymal transition of uterine endometrial cancer cells by inhibiting SP1 function.

    Asanoma kazuo, Sonoda kenzo, Kato kiyoko

    第58回日本婦人科腫瘍学会学術講演会  2016.7 

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    Event date： 2021.5

    Language：English   Presentation type：Oral presentation (general)  

    Venue：米子   Country：Japan  

  • The MIR130 families suppress epithelial-to-mesenchymal transition of uterine endometrial cancer cells by inhibiting the expression of BHLHE40 and BHLHE41.

    Kazuo Asanoma, Hiroshi Yagi, Ichiro Onoyama, Kenzo Sonoda, Kiyoko Kato

    第69回日本産科婦人科学会学術講演会,  2017.4 

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    Event date： 2021.5

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Venue：広島   Country：Japan  

  • The MIR130 families suppress epithelial-to-mesenchymal transition of uterine endometrial cancer cells by inhibiting the expression of BHLHE40 and BHLHE41.

    Kazuo Asanoma, Hiroshi Yagi, Ichiro Onoyama, Kenzo Sonoda, Kiyoko Kato

    第59回日本婦人科腫瘍学会学術講演会  2017.7 

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    Event date： 2021.5

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Mutual regulation between MIR301B-MIR130B and BHLHE40-BHLHE41 is involved in epithelial-to-mesenchymal transition of uterine endometrial cancer cells. International conference

    Kazuo Asanoma, Hiroshi Yagi, Ichirou Onoyama, Kenzo Sonoda, Kiyoko Kato

    17th Biennial Meeting of the International Gynecologic Cancer Society  2018.9 

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    Event date： 2021.5

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Kyoto   Country：Japan  

  • Mutual regulation between MIR301B-MIR130B and BHLHE40-BHLHE41 is involved in epithelial-to-mesenchymal transition of uterine endometrial cancer cells.

    Kazuo Asanoma, Hiroshi Yagi, Ichirou Onoyama, Kenzo Sonoda, Kiyoko Kato

    第71回日本産科婦人科学会学術講演会  2019.4 

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    Event date： 2021.5

    Language：English   Presentation type：Oral presentation (general)  

    Venue：名古屋   Country：Japan  

  • Transcriptional regulation by BHLHE40/BHLHE41 and SP1 is involved in the expression of oncogenic microRNAs, MIR301B and MIR130B, in uterine endometrial cancer cells.

    Kazuo Asanoma, Hiroshi Yagi, Ichirou Onoyama, Keisuke Kodama, Masafumi Yasunaga, Tatsuhiro Ohgami, Nobuko Yasutake, Masako Kijima, Eisuke Kaneki, Kaoru Okugawa, Hideaki Yahata, Kiyoko Kato

    第72回日本産科婦人科学会学術講演会  2020.4 

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    Event date： 2021.5

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：東京   Country：Japan  

  • Transcriptional regulation of oncogenic microRNAs, MIR301B and MIR130B by BHLHE40/BHLHE41 and SP1 is involved in uterine endometrial cancer cells.

    Asanoma kazuo, Yagi Hiroshi, Onoyama Ichiro, Kodama Keisuke, Kijima Masako, Yasutake Nobuko, Yasunaga Masafumi, Ohgami Tatsuhiro, Kenjo Hironori, Okugawa Kaoru, Yahata Hideaki, Kato Kiyoko

    第62回日本婦人科腫瘍学会学術講演会  2021.1 

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    Event date： 2021.5

    Language：English   Presentation type：Oral presentation (general)  

    Venue：仙台   Country：Japan  

  • ダイオキシン受容体は一塩基多型依存的に転写制御され、子宮体癌の増殖・浸潤に関わる

    淺野間 和夫, 髙尾 知佳, 恒松 良祐, 諸隈 誠一, 福嶋恒太郎, 小林 裕明, 齋藤俊章, 加藤 聖子, 和氣徳夫

    第54回日本婦人科腫瘍学会学術講演会  2013.7 

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    Event date： 2013.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

  • ダイオキシン受容体は一塩基多型依存的に転写制御され、子宮体癌の増殖・浸潤に関わる

    淺野間 和夫, 髙尾 知佳, 恒松 良祐, 諸隈 誠一, 福嶋恒太郎, 小林 裕明, 齋藤俊章, 加藤 聖子, 和氣徳夫

    第12回に本婦人科がん分子標的研究会学術集会  2013.7 

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    Event date： 2013.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：奈良   Country：Japan  

  • 転写因子NF1Cは一塩基多型依存的にダイオキシン受容体の転写を抑制し、子宮内膜癌の増殖・浸潤を制御する

    淺野間 和夫, 恒松 良祐, 諸隈　誠一, 福嶋 恒太郎, 小林 裕明, 齋藤　俊章, 加藤 聖子, 和氣　徳夫

    第65回日本産婦人科学会学術講演会  2013.5 

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    Event date： 2013.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：札幌   Country：Japan  

  • マウス栄養膜細胞の分化を制御する新たな分子、核マトリックス関連分子Satb1, Satb2の解析

    浅野間和夫、福嶋恒太郎、和氣徳夫

    日本産科婦人科学会第６４回学術講演会  2012.4 

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    Event date： 2012.4

    Presentation type：Oral presentation (general)  

    Venue：神戸   Country：Japan  

  • Establishment of trophoblast cell lines from rat blastocysts possessing the capacity to differentiate into multiple trophoblast cell lineage

    Asanoma Kazuo、Wake Noio

    63th Annual Congress of the Japan Society of Obstetrics and Gynecology  2011.8 

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    Event date： 2011.8

    Presentation type：Oral presentation (general)  

    Venue：Osaka   Country：Japan  

  • Isolation of stem cells from rat blastocysts possessing the capacity to differentiate along the trophoblast cell lineage International conference

    Asanoma K, Lee Dong-Soo, Soares Michael J

    The 5th annual Gilberts S Greenwald Symposium on Reproduction  2008.2 

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    Event date： 2011.2

    Presentation type：Oral presentation (general)  

    Venue：Kansas City   Country：United States  

    Other Link： http://www2.kumc.edu/crs/greenwald/index.html

  • ラット栄養膜幹細胞株樹立の試み

    浅野間和夫、和氣徳夫、Dong-Soo Lee, Lindsey N. Kent, M.A. Karim Rumi and Michael J. Soares

    第18回日本胎盤学会学術集会  2010.9 

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    Event date： 2010.9 - 2010.10

    Presentation type：Oral presentation (general)  

    Venue：熊本市   Country：Japan  

  • Isolation of stem cells from rat blastocysts possessing the capacity to differentiate along the trophoblast cell lineage International conference

    Asanoma K, Lee Dong-Soo, Soares Michael J

    International Society of Stem Cell Research (ISSCR) 6th annual meeting  2008.6 

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    Event date： 2008.6 - 2011.6

    Presentation type：Oral presentation (general)  

    Venue：Philadelphia   Country：United States  

    Other Link： http://www.isscr.org/

  • 母親相互転座に関与した２０番短腕トリソミー・10番長腕モノソミーの症例

    浅野間和夫、松田貴雄、加藤秀則、近藤晴彦、和氣徳夫

    第５２回日本産科婦人科学会九州連合地方部会  1998.1 

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    Presentation type：Oral presentation (general)  

    Venue：大分   Country：Japan  

  • 胎盤特異的cDNAライブラリーの作成

    浅野間和夫、松田貴雄、近藤晴彦、加藤秀則、和氣徳夫

    第３回日本産婦人科腫瘍マーカー・遺伝子診断学会  1999.2 

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    Presentation type：Oral presentation (general)  

    Venue：佐賀市   Country：Japan  

  • 胎盤特異的cDNAライブラリーの作成

    浅野間和夫、松田貴雄、近藤晴彦、加藤秀則、和氣徳夫

    第51回　日本産科婦人科学会学術講演会  1999.4 

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    Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

  • 卵管通過障害に対して卵管鏡下卵管形成術を施行した15症例の検討

    浅野間和夫、松田貴雄、栗秋ユミ子、加藤秀則、和氣徳夫

    第50回　日本母性保護産婦人科医会九州ブロック会学術講演会  1999.5 

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    Presentation type：Oral presentation (general)  

    Venue：佐賀   Country：Japan  

  • 卵管通過障害に対して卵管鏡下卵管形成術を施行した15症例の検討

    浅野間和夫、松田貴雄、栗秋ユミ子、加藤秀則、和氣徳夫

    第11回　大分内視鏡下外科手術研究会  1999.6 

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    Presentation type：Oral presentation (general)  

    Venue：大分   Country：Japan  

  • 絨毛癌抑制に関わる遺伝子の単離

    浅野間和夫、松田貴雄、近藤晴彦、小川昌宣、周　勇、加藤秀則、和気徳夫

    第５２回　日本産科婦人科学会学術講演会  2000.4 

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    Presentation type：Oral presentation (general)  

    Venue：徳島   Country：Japan  

  • 高インスリン血症を呈する不妊患者に対するインスリン抵抗性改善薬の効果の検討

    浅野間和夫、松田貴雄、近藤晴彦、小川昌宣、加藤秀則、和氣徳夫

    第11回　日本不妊学会春季九州支部会  2000.4 

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    Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • Construction of placenta specific cDNA library. International conference

    Asanoma K, Matsuda T, Kondoh H, Ogawa M, Zhou Y, Kato H, Nakano H, Wake N

    AOCOG 2000  2000.7 

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    Presentation type：Oral presentation (general)  

    Venue：Singapore   Country：Singapore  

  • 多嚢胞卵巣症候群に対するインスリン抵抗性改善メトフォルミンの使用経験

    浅野間和夫、松田貴雄、近藤晴彦、加藤秀則、和氣徳夫

    第45回　日本不妊学会  2000.11 

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    Presentation type：Oral presentation (general)  

    Venue：神戸   Country：Japan  

  • 排卵障害を伴う不妊患者のインスリン抵抗性の評価と改善薬の使用経験

    浅野間和夫、松田貴雄、近藤晴彦、加藤秀則、和氣徳夫

    第58回　日本産科婦人科学会九州連合地方部会  2001.10 

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    Presentation type：Oral presentation (general)  

    Venue：久留米   Country：Japan  

  • 絨毛癌の癌抑制に関わる新規候補遺伝子の報告

    浅野間和夫、松田貴雄、近藤晴彦、周勇、加藤秀則、和氣徳夫

    第19回　絨毛性疾患研究会  2001.10 

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    Presentation type：Oral presentation (general)  

    Venue：大阪   Country：Japan  

  • 絨毛癌の癌化抑制および絨毛分化に関わる新規候補遺伝子NECC1

    浅野間和夫、松田貴雄、近藤晴彦、加藤秀則、和氣徳夫

    第54回　日本産科婦人科学会学術講演会  2002.4 

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    Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

  • 多嚢胞性卵巣症候群患者に対するインスリン抵抗性改善の試み〜薬物療法と温泉運動療法のインスリン抵抗性改善効果の比較

    浅野間和夫、松田貴雄、和氣徳夫

    第４７回　日本不妊学会学術講演会  2002.10 

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    Presentation type：Oral presentation (general)  

    Venue：岐阜   Country：Japan  

  • 絨毛癌の癌化抑制および絨毛分化に関わる新規候補遺伝子NECC1の解析

    浅野間和夫、松田貴雄、加藤秀則、和氣徳夫

    第55回　日本産科婦人科学会学術講演会  2003.4 

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    Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Japan  

  • Analysis of a candidate gene which is associated with growth suppression of choriocarcinoma and differentiation of trophoblasts. International conference

    K. Asanoma, T. Matsuda, H. Kato, H. Kondo, T. Inoue and N. Wake

    XIIth World congress on gestational trophoblastic diseases.  2003.10 

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    Presentation type：Oral presentation (general)  

    Venue：Boston, MA   Country：United States  

  • 絨毛癌抑制および絨毛分化に関わるNECC1の解析

    浅野間和夫、加藤秀則、井上貴史、松田貴雄、和氣徳夫

    第20回　日本絨毛性疾患研究会  2003.11 

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    Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

  • 造腫瘍能抑制効果をもつNECC1遺伝子の胎盤形成における働き

    浅野間和夫、加藤秀則、松田貴雄、井上貴史、和氣徳夫

    第56回日本産科婦人科学会学術講演会  2004.4 

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    Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

  • Necc1遺伝子の栄養膜細胞分化・胎盤形成における働き

    浅野間和夫、加藤秀則、松田貴雄、井上貴史、山口真一郎、和氣徳夫

    第57回日本産科婦人科学会学術講演会  2005.4 

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    Presentation type：Oral presentation (general)  

    Venue：京都   Country：Japan  

  • マウス栄養膜細胞の分化、胎盤形成に関わる遺伝子NECC1の解析

    浅野間和夫、加藤秀則、和氣徳夫

    第１３回日本胎盤学会  2005.10 

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    Presentation type：Oral presentation (general)  

    Venue：富山   Country：Japan  

  • 子宮体癌の癌化機構におけるNECC1遺伝子の関与

    浅野間和夫、山口真一郎、加藤聖子、大神達寛、和氣徳夫

    第５８回日本産婦人科学会学術講演会  2006.4 

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    Presentation type：Oral presentation (general)  

    Venue：横浜   Country：Japan  

  • 子宮内膜癌の癌化機構におけるNECC1遺伝子の関与

    浅野間和夫　加藤聖子　和氣徳夫

    第６５回　日本癌学会学術総会  2006.9 

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    Presentation type：Oral presentation (general)  

    Venue：横浜   Country：Japan  

  • ホメオボックス遺伝子NECC1のマウス栄養膜細胞における働き

    浅野間和夫、加藤聖子、和氣徳夫

    第５９回　日本産科婦人科学会総会学術講演会  2007.4 

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    Presentation type：Oral presentation (general)  

    Venue：京都   Country：Japan  

▼display all

MISC

  • Establishment of a new diagnostic method for hydropic villi by using TSSC3 antibody

    和氣徳夫, 髙尾 知佳, 淺野間 和夫, 加藤秀則

    Journal of Obstetrics and Gynecology Research   2013.6

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    Language：English   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Trophoblast stem cells derived from nuclear transfer embryos: phenotypically unique, bad neighbors, or poor communicators?

    Soares MJ, Asanoma K

    Proc Natl Acad Sci U S A   2009.2

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    Language：English   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 特集　胎盤の基礎と臨床　絨毛細胞の分化機構

    福嶋 恒太郎, 淺野間 和夫, 和氣 徳夫

    産科と婦人科/診断と治療社   2007.7

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 癌遺伝子治療への臨床応用

    浅野間和夫、加藤秀則、和氣徳夫

    2002.1

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

Professional Memberships

  • 日本人類遺伝学会

  • 日本産婦人科学会

  • The American Society for Biochemistry and Molecular Biology

  • International Society for Stem Cell Research

  • 日本婦人科腫瘍学会

Committee Memberships

  • 日本産科婦人科学会福岡地方部会   Councilor   Domestic

    2012.6 - 2021.6   

Academic Activities

  • Screening of academic papers

    Role(s)： Peer review

    2020

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：14

  • Screening of academic papers

    Role(s)： Peer review

    2019

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：12

  • Screening of academic papers

    Role(s)： Peer review

    2018

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：15

  • Screening of academic papers

    Role(s)： Peer review

    2017

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：11

  • Screening of academic papers

    Role(s)： Peer review

    2016

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：7

  • Screening of academic papers

    Role(s)： Peer review

    2015

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：3

  • Screening of academic papers

    Role(s)： Peer review

    2014

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：1

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Research Projects

  • 子宮体癌細胞の上皮間葉移行を介した浸潤能に関わる代謝調節機構の解明

    Grant number：21K09519  2021 - 2023

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • マイクロRNAを介した子宮体癌の進展制御を司る新たな分子機構の解明

    Grant number：17K11280  2017 - 2019

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 転写調節機構から見た子宮体癌の浸潤・転移機構を司る新たな分子機構の解明

    Grant number：26462529  2014 - 2016

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 子宮体癌の増殖浸潤を制御する新たな分子機構の解明と治療法の開発

    2013 - 2015

    武田科学振興財団　研究奨励費

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    Authorship：Principal investigator  Grant type：Contract research

  • 産科ストレスの視点から見た胎盤機能不全における絨毛細胞機能障害機構の解明

    Grant number：23591596  2011 - 2013

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

  • マウス胎盤形成に関わる核マトリックス関連蛋白Satbの解析

    Grant number：23592405  2011 - 2013

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 転写因子ＳＲＦを中心とするマウス栄養膜細胞の新たな分化調節機構の解明

    Grant number：19791154  2007 - 2008

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 栄養膜細胞の分化を制御し、胎盤形成に関わる新規遺伝子NECC１の解析

    2006

    神澤医学研究財団研究助成金

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    Authorship：Principal investigator  Grant type：On-campus funds, funds, etc.

  • 胎盤形成を制御し、癌抑制機能をもつ新規遺伝子NECC1の解析

    Grant number：17791124  2005 - 2006

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 絨毛癌抑制遺伝子の単離

    2001 - 2003

    Japan Society for the Promotion of Science  Research Fellowships for Young Scientists

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    Authorship：Principal investigator  Grant type：Joint research

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Educational Activities

  • Bedside education for medical students
    Bedside education for resident physicians
    Bedside education for internship medical doctors
    Giving lectures for medical students

Class subject

  • 医学総合講義「生殖と免疫」

    2020.10 - 2021.3   Second semester

  • 医学総合講義「生殖と免疫」

    2019.10 - 2020.3   Second semester

  • 医学総合講義「生殖と免疫」

    2018.10 - 2019.3   Second semester

  • 医学総合講義「生殖と免疫」

    2013.10 - 2014.3   Second semester

  • 医学部６年生臨床医学実習

    2013.4 - 2014.3   Full year

  • 受胎・成長・発達

    2013.4 - 2013.9   First semester

  • 医学総合講義「生殖と免疫」

    2012.10 - 2013.3   Second semester

  • 医学部５年生臨床医学実習

    2012.4 - 2013.3   Full year

  • 受胎・成長・発達

    2012.4 - 2012.9   First semester

  • 医学総合講義「生殖と免疫」

    2011.10 - 2012.3   Second semester

  • 医学部５年生臨床医学実習

    2011.4 - 2012.3   Full year

  • 受胎・成長・発達

    2011.4 - 2011.9   First semester

  • 医学総合講義「生殖と免疫」

    2010.10 - 2011.3   Second semester

  • 医学部５年生臨床医学実習

    2010.4 - 2011.3   Full year

  • 助産診断技術学

    2010.4 - 2010.9   First semester

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Travel Abroad

  • 2007.9 - 2010.3

    Staying countory name 1：United States   Staying institution name 1：Kansas University Medical Center

  • 2003.2

    Staying countory name 1：United States   Staying institution name 1：Southwestern Medical Center, Texas Univeristy

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Surgical Clinical Medicine / Obstetrics and Gynecology

Clinician qualification

  • Specialist

    Japan Society of Obstetrics and Gynecology（JSOG）

Year of medical license acquisition

  • 1996

Notable Clinical Activities

  • 当科ならびに多施設臨床研究に協力している