Updated on 2024/06/10

Information

 

写真a

 
ASANOMA KAZUO
 
Organization
Faculty of Medical Sciences Associate Professor
Title
Associate Professor
Profile
・Basic research about the differentiation of murine and human trophoblasts ・Basic research about the molecular process of carcinogenesis of uterine endometrial cancer ・Educational activity for doctoral course students ・Medical treatment, surgery ・Educational activity for resident physicians ・Educational activity for internship medical doctors ・Educational activity for medical college students
External link

Degree

  • MD and PhD

Research Interests・Research Keywords

  • Research theme:Regulation of energy metabolism involved in the epithelial-to-mesenchymal transition of endometrial cancer cells

    Keyword:glycolysis, oxidative phosphorylation, epithelial-to-mesenchymal transition, cell invasion, endometrial cancer

    Research period: 2020.4 - 2024.3

  • Research theme:The mechanism regulating development of endometrial cancer cells by microRNAs

    Keyword:microRNA, endometrial cancer, epithelial-to-mesenchymal transition

    Research period: 2017.4 - 2019.3

  • Research theme:Molecular mechanism involving nuclear matrix associated gene SATB in uterine endometrial carcinogenesis

    Keyword:uterine endometrial cancer, SATB1, SATB2

    Research period: 2013.1 - 2015.3

  • Research theme:Functional analysis of dioxin receptor involved in development of uterine endometrial cancer

    Keyword:aryl hydrocarbon receptor (AHR), uterine endometrial cancer, invasion, proliferation

    Research period: 2011.8 - 2012.8

  • Research theme:Elucidation of a novel mechanism of murine trophoblast stem cell differentiation: involvement of nuclear matrix associated molecules, Satb

    Keyword:murine trophoblast stem cell, differentiation

    Research period: 2011.4 - 2014.3

  • Research theme:Establishment of rat placenta trophoblast stem cell lines

    Keyword:rat, placenta, trophoblast stem cells

    Research period: 2007.9 - 2010.12

  • Research theme:Homeobox gene HOPX is epigenetically silenced in human uterine endometrial cancer and suppresses estrogen-stimulated proliferation of cancer cells by inhibiting serum response factor

    Keyword:uterine endometrial cancer, NECC1, SRF, c-fos

    Research period: 2005.7 - 2008.12

  • Research theme:HOP/NECC1, a novel regulator of mouse trophoblast differentiation

    Keyword:placenta, trophoblast, differentiation

    Research period: 2003.1 - 2007.6

  • Research theme:絨毛癌抑制遺伝子の単離

    Keyword:絨毛癌、癌抑制遺伝子

    Research period: 1998.4 - 2002.12

Papers

  • Mutual suppression between BHLHE40/BHLHE41 and the MIR301B-MIR130B cluster is involved in epithelial-to-mesenchymal transition of endometrial cancer cells Reviewed

    Kazuo Asanoma, Emiko Hori, Sachiko Yoshida, Hiroshi Yagi, Ichiro Onoyama, Keisuke Kodama, Masafumi Yasunaga, Tatsuhiro Ohgami, Eisuke Kaneki, Kaoru Okugawa, Hideaki Yahata, Kiyoko Kato

    Oncotarget   10 ( 45 )   4640 - 4654   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18632/oncotarget.27061

  • Regulation of the Mechanism of TWIST1 Transcription by BHLHE40 and BHLHE41 in Cancer Cells

    KAZUO ASANOMA, Ge Liu, Takako Yamane, Yoko Miyanari, Tomoka Takao, Hiroshi Yagi, Tatsuhiro Ohgami, AKIMASA ICHINOE, Kenzo Sonoda, Norio Wake, Kiyoko Kato

    MOLECULAR AND CELLULAR BIOLOGY   35 ( 24 )   2015.12

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    Language:English  

    DOI: 10.1128/MCB.00678-15

  • Inhibition of AHR transcription by NF1C is affected by a single nucleotide polymorphism, and is involved in suppression of human uterine endometrial cancer Reviewed International journal

    Dan Li, Tomoka Takao, Ryosuke TSUNEMATSU, Seiichi Morokuma, Kotaro Fukushima, Hiroaki Kobayashi, Toshiaki Saito, Masutaka Furue, Norio Wake, KAZUO ASANOMA

    Oncogene   30   4950 - 4959   2013.10

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    Language:English   Publishing type:Research paper (scientific journal)  

  • SATB homeobox proteins regulate trophoblast stem cell renewal and differentiation. Reviewed International journal

    Asanoma K, Kubota K, Chakraborty D, Renaud SJ, Wake N, Fukushima K, Soares MJ, Rumi MA.

    Journal of Biological Chemistry   287 ( 3 )   2012.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  • FGF4-dependent stem cells derived from rat blastocysts differentiate along the trophoblast lineage. Reviewed International journal

    Asanoma K, Rumi MA, Kent LN, Chakraborty D, Renaud SJ, Wake N, Lee DS, Kubota K, Soares MJ

    Developmental Biology   351 ( 1 )   2011.3

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    Language:English   Publishing type:Research paper (scientific journal)  

  • HOPX is epigenetically silenced in human uterine endometrial cancer and suppresses estrogen-stimulated proliferation of cancer cells by inhibiting serum response factor. Reviewed International journal

    *Yamaguchi S, *Asanoma K, Takao T, Kato K, Wake N

    International Journal of Cancer   124 ( 11 )   2009.6

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    Language:English   Publishing type:Research paper (scientific journal)  

  • HOP/NECC1, A Novel Regulator of Mouse Trophoblast Differentiation Reviewed International journal

    Asanoma K., Kato H., Yamaguchi S., Shin C. H., Liu Z. P. Kato K., Inoue T., Miyanari Y., Yoshikawa K., Sonoda K., Fukushima K. and Wake N

    Journal of Biological Chemistry   282 ( 33 )   2007.7

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    Language:English   Publishing type:Research paper (scientific journal)  

  • NECC1, a candidate choriocarcinoma suppressor gene which encodes homeodomain consensus motif. Reviewed International journal

    Asanoma K, Matsuda T, Kondo H, Kato K, Kishino T, Niikawa N, Wake N, Kato H

    Genomics   81 ( 1 )   15 - 25   2003.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0888-7543(02)00011-3

  • Prognostic outcomes and risk factors for recurrence after laser vaporization for cervical intraepithelial neoplasia: a single-center retrospective study. Reviewed International journal

    Kodama Keisuke, Yahata Hidenori, Okugawa Kaoru, Tomonobe Hiroshi, Yasutake Nobuko, Yoshida Sachiko, Yagi Hiroshi, Yasunaga Masafumi, Ohgami Tatsuhiro, Onoyama Ichiro, Asanoma Kazuo, Hori Emiko, Shimokawa Mototsugu, Kato Kiyoko

    International Journal of Clinical Oncology   26 ( 4 )   770 - 776   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10147-020-01848-x

  • Hypersensitivity reaction to pegylated liposomal doxorubicin administration for Mullerian carcinoma in Japanese women. Reviewed International journal

    Yamaguchi Shinichiro, Yahata Hideaki, Okugawa Kaoru, Kodama Keisuke, Yagi Hiroshi, Yasunaga Masafumi, Ohgami Tatsuhiro, Onoyama Ichiro, Asanoma Kazuo, Kato Kiyoko

    Journal of Obstetrics and Gynaecology Research   47 ( 4 )   1544 - 1548   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.14680

  • Prognostic impact of the subclassification of Müllerian cancer stage IV in the FIGO 2014 staging system with a focus of extra-abdominal lymph node metastases. Reviewed International journal

    2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10147-021-01908-w

  • Identification of genes associated with endometrial cell ageing. Reviewed International journal

    Kawamura Teruhiko, Tomari Hiroyuki, Onoyama Ichiro, Araki Hiromitsu, Yasunaga Masafumi, Lin Cui, Kawamura Keiko, Yokota Natsuko, Yoshida Sachiko, Yagi Hiroshi, Asanoma Kazuo, Sonoda Kenzo, Egashira Katsuko, Ito Takahiro, Kato Kiyoko

    Molecular Human Reproduction   27 ( 2 )   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/molehr/gaaa078

  • YBX2 and cancer testis antigen 45 contribute to stemness, chemoresistance and a high degree of malignancy in human endometrial cancer. Invited Reviewed International journal

    Suzuki Izumi, Yoshida Sachiko, Tabu Kouichi, Kusunoki Soshi, Matsumura Yumiko, Izumi Hiroto, Asanoma Kazuo, Yagi Hiroshi, Onoyama Ichiro, Sonoda Kenzo, Kohno Kimitoshi, Taga Tetsuya, Itakura Atsuo, Takeda Satoru, *Kato Kato

    Scientific Reports   11 ( 1 )   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-83200-5

  • Fibronectin mediates activation of stromal fibroblasts by SPARC in endometrial cancer cells. Invited Reviewed International journal

    Yoshida Sachiko, Asanoma Kazuo, Yagi Hiroshi, Onoyama Ichiro, Hori Emiko, Matsumura Yumiko, Okugawa Kaoru, Yahata Hideaki, Kato Kiyoko

    BMC Cancer   21 ( 1 )   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12885-021-07875-9

  • Evaluation of adjuvant chemotherapy after abdominal trachelectomy for cervical cancer: a single-institution experience. Reviewed International journal

    Okugawa Kaoru, Yahata Hideaki, Sonoda Kenzo, Kodama Keisuke, Yagi Hiroshi, Ohgami Tatsuhiro, Yasunaga Masafumi, Onoyama Ichiro, Kaneki Eisuke, Asanoma Kazuo, Kobayashi Hirosaki, Kato Kiyoko

    International Journal of Clinical Oncology   26 ( 1 )   216 - 224   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10147-020-01778-8

  • Downregulation of 5-hydroxymethylcytosine is associated with the progression of cervical intraepithelial neoplasia. Reviewed International journal

    Kato Masaya, Onoyama Ichiro, Kawakami Minoru, Yoshida Sachiko, Kawamura Keiko, Kodama Keisuke, Hori Emiko, Cui Lin, Matsumura Yumiko, Yagi Hiroshi, Asanoma Kazuo, Yahata Hideaki, Itakura Atsuo, Takeda Satoru, Kato Kiyoko

    PLoS One   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0241482

  • Dual-specificity phosphatase 6 plays a critical role in the maintenance of a cancer stem-like cell phenotype in human endometrial cancer. Reviewed International journal

    Kato Masaya, Onoyama Ichiro, Yoshida Sachiko, Cui Lin, Kawamura Keiko, Kodama Keisuke, Hori Emiko, Matsumura Yumiko, Yagi Hiroshi, Asanoma Kazuo, Yahata Hideaki, Itakura Atsuo, Takeda Satoru, Kato Kiyoko

    International Journal of Cancer   147 ( 7 )   1987 - 1999   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ijc.32965

  • Is Adjuvant Therapy Necessary for Patients with Intermediate-Risk Cervical Cancer after Open Radical Hysterectomy? Invited Reviewed International journal

    Yahata Hideaki, Sonoda Kenzo, Inoue Shusaku, Yasutake Nobuko, Kodama Keisuke, Yagi Hiroshi, Yasunaga Masafumi, Ohgami Tatsuhiro, Onoyama Ichiro, Kaneki Eisuke, Okugawa Kaoru, Asanoma Kazuo, Kato Kiyoko

    Oncology   98 ( 12 )   853 - 858   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000508569

  • Contribution of senescence in human endometrial stromal cells during proliferative phase to embryo receptivity. Reviewed International journal

    Tomari Hiroyuki, Kawamura Teruhiko, Asanoma Kazuo, Egashira Katsuko, Kawamura Keiko, Honjo Ko, Nagata Yumi, Kato Kiyoko

    Biology of Reproduction   103 ( 1 )   104 - 113   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/biolre/ioaa044

  • Gα13-mediated LATS1 down-regulation contributes to epithelial-mesenchymal transition in ovarian cancer. Reviewed International journal

    33 ( 12 )   13683 - 13694   2019.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1096/fj.201901278R

  • Survey of the desire to have children and engage in sexual activity after trachelectomy among young Japanese women with early-stage cervical cancer Reviewed

    Hideaki Yahata, Kenzo Sonoda, Kaoru Okugawa, Hiroshi Yagi, Tatsuhiro Ohgami, Masafumi Yasunaga, Ichiro Onoyama, Eisuke Kaneki, Kazuo Asanoma, Kiyoko Kato

    Journal of Obstetrics and Gynaecology Research   45 ( 11 )   2255 - 2259   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.14099

  • Fibrosis in Preeclamptic Placentas Is Associated with Stromal Fibroblasts Activated by the Transforming Growth Factor-β1 Signaling Pathway Reviewed

    188 ( 3 )   683 - 695   2018.3

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    Although fibrosis is one of the most prominent pathologic features of preeclamptic (PE) placentas, its mechanism remains largely unknown. Consistent with previous reports, we observed overexpression of collagen; actin, α2, smooth muscle, aorta; connective tissue growth factor; and fibronectin in PE placentas compared with control ones. To investigate the mechanism of fibrosis in PE placentas, placental fibroblasts were isolated from PE placentas or normal pregnancies at delivery. The expression of fibrosis-related factors in fibroblasts was evaluated by real-time RT-PCR, Western blotting, enzyme-linked immunosorbent assay, and gene microarrays. An in vitro collagen gel contraction assay was also performed. Fibroblasts isolated from PE placentas showed higher expression levels of fibrosis-related factors compared with those from control ones. Global gene expression profiling of PE fibroblasts was contrasted with that of control ones and indicated an intimate association with transforming growth factor-β1 (TGFB1) signaling. Furthermore, the PE fibroblasts expressed abundant phosphorylated SMAD family member 2 and showed higher expression levels of target genes of TGFB1 signaling compared with the control ones. The PE fibroblasts also had a greater ability to contract compared with the control ones. Contractility also depended on TGFB1 signaling. Our results suggest that TGFB1 signaling is activated in the fibroblasts in PE placentas and that these active fibroblasts contribute to fibrosis.

    DOI: 10.1016/j.ajpath.2017.11.008

  • FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors Reviewed

    Shoko Kitade, Ichiro Onoyama, Hiroaki Kobayashi, Hiroshi Yagi, Sachiko Yoshida, Masaya Kato, Ryosuke Tsunematsu, Kazuo Asanoma, Kenzo Sonoda, Norio Wake, Kenichiro Hata, Keiichi I. Nakayama, Kiyoko Kato

    Cancer Science   107 ( 10 )   1399 - 1405   2016.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13026

  • GEP oncogene promotes cell proliferation through YAP activation in ovarian cancer Reviewed

    H. Yagi, K. Asanoma, T. Ohgami, A. Ichinoe, K. Sonoda, K. Kato

    Oncogene   35 ( 34 )   4471 - 4480   2016.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/onc.2015.505

  • Identification of the critical site of calponin 1 for suppression of ovarian cancer properties Reviewed

    Takako Yamane, Kazuo Asanoma, Hiroaki Kobayashi, Ge Liu, Hiroshi Yagi, Tatsuhiro Ohgami, Akimasa Ichinoe, Kenzo Sonoda, Norio Wake, Kiyoko Kato

    Anticancer research   35 ( 11 )   5993 - 5999   2015.11

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  • SNP55, a new functional polymorphism of MDM2-P2 promoter, contributes to allele-specific expression of MDM2 in endometrial cancers Reviewed

    Kanako Okamoto, Ryosuke Tsunematsu, Tomoko Tahira, Kenzo Sonoda, Kazuo Asanoma, Hiroshi Yagi, Tomoko Yoneda, Kenshi Hayashi, Norio Wake, Kiyoko Kato

    BMC Medical Genetics   16 ( 1 )   2015.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12881-015-0216-8

  • Aryl hydrocarbon receptor SNP-130 C/T associates with dioxins susceptibility through regulating its receptor activity and downstream effectors including interleukin 24

    Ge Liu, KAZUO ASANOMA, Tomoka Takao, Kiyomi Tsukimori, Uchi Hiroshi, Masutaka Furue, Kiyoko Kato, Norio Wake

    TOXICOLOGY LETTERS   232 ( 2 )   2015.1

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    Language:English  

    DOI: 10.1016/j.toxlet.2014.11.025

  • The maternally expressed gene Tssc3 regulates the expression of MASH2 transcription factor in mouse trophoblast stem cells through the AKT-Sp1 signaling pathway. Reviewed International journal

    Tomoka Takao, KAZUO ASANOMA, Ryosuke TSUNEMATSU, Kiyoko Kato, Norio Wake

    Journal of Biological Chemistry   287 ( 51 )   42685 - 42694   2012.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M112.388777

  • Isolation and characterization of human trophoblast side-population (SP) cells in primary villous cytotrophoblasts and HTR-8/SVneo cell line. Reviewed International journal

    Takao T, Asanoma K, Kato K, Fukushima K, Tsunematsu R, Hirakawa T, Matsumura S, Seki H, Takeda S, Wake N

    PLosOne   6 ( 7 )   2011.7

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  • Chromosome-substituted rat strains provide insights into the genetics of placentation. Reviewed International journal

    Konno T, Rempel LA, Rumi MA, Graham AR, Asanoma K, Renaud SJ, Soares MJ.

    Physiolocgical Genomics   43 ( 15 )   2011.6

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  • Level of reactive oxygen species induced by p21Waf1/CIP1 is critical for the determination of cell fate. Reviewed International journal

    Inoue T, Kato K, Kato H, Asanoma K, Kuboyama A, Ueoka Y, Yamaguchi S, Ohgami T, Wake N

    Cancer Science   100 ( 7 )   2010.2

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  • Endometrial cancer side-population cells show prominent migration and have a potential to differentiate into the mesenchymal cell lineage. Reviewed International journal

    Kato K, Takao T, Kuboyama A, Tanaka Y, Ohgami T, Yamaguchi S, Adachi S, Yoneda T, Ueoka Y, Kato K, Hayashi S, Asanoma K, Wake N

    American Journal of Pathology   176 ( 1 )   2010.2

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  • Hypoxia inducible factor 1 alpha regulates matrigel-induced endovascular differentiation under normoxia in a human extravillous trophoblast cell line. Reviewed International journal

    Fukushima K, Murata M, Hachisuga M, Tsukimori K, Seki H, Takeda S, Asanoma K, Wake N

    Placenta   29 ( 4 )   2008.2

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  • Medroxyprogesterone acetate inhibits proliferation of colon cancer cell lines by modulating cell cycle-related protein expression Reviewed International journal

    Tanaka Y, Kato K, Mibu R, Uchida S, Asanoma K, Hashimoto K, Nozaki M, Wake N

    Menopause   15 ( 3 )   2008.2

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  • Characterization of side-population cells in human normal endometrium. Reviewed International journal

    Kato K, Yoshimoto M, Kato K, Adachi S, Yamayoshi A, Arima T, Asanoma K, Kyo S, Nakahatat T, Wake N

    Human Reproduction   22 ( 5 )   2007.5

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  • An inhibitory effect on cell proliferation by blockage of the MAPK/estrogen receptor/MDM2 signal pathway in gynecologic cancer. Reviewed International journal

    Suga S, Kato K, Ohgami T, Yamayoshi A, Adachi S, Asanoma K, Yamaguchi S, Arima T, Kinoshita K, Wake N

    Gycecologic Oncology   105 ( 2 )   2006.5

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  • Induction of human endometrial cancer cell senescence through modulation of HIF-alpha activity by EGLN1. Reviewed International journal

    Kato H., Inoue T., Asanoma K., Nishimura C., Matsuda T. and Wake N.

    International Journal of Cancer   118 ( 5 )   2006.1

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  • Activation of STAT3/5 signal pathways in complete mole and repression in choriocarcinoma cell lines. Reviewed International journal

    Kato H, Inoue T, Asanoma K, Matsuda T, Yoshikawa Y, Wake N

    Journal of Reproductive Medicine   51 ( 1 )   2006.1

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  • Differential Diagnosis Between Complete and Partial Mole by TSSC3 Antibody Completely Correlates to DNA Diagnosis. Reviewed International journal

    Kato, H., Matsuda, T., Hirakawa, T., Ueda, K., Inoue, T., Miyanari, Y., Asanoma, K., Nakano, H. and Wake, N.

    Diagn. Mol. Pathol.   14 ( 3 )   164 - 169   2005.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/01.pas.0000162757.91649.a3

  • Analysis of a candidate gene associated with growth suppression of choriocarcinoma and differentiation of trophoblasts. Invited International journal

    Asanoma K, Kato H, Inoue T, Matsuda T, Wake N

    Journal of Reproductive Medicine   49 ( 8 )   617 - 626   2004.8

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  • Expression of DCC and netrin-1 in normal human endometrium and its implication in endometrial carcinogenesis. Reviewed International journal

    Kato, H.D., Kondoh, H., Inoue, T., Asanoma, K., Matsuda, T., Arima, T., Kato, K., Yoshikawa, T. and Wake, N.

    Gynecol. Oncol.   95 ( 2 )   281 - 289   2004.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ygyno.2004.07.050

  • Identification of FOXC1 as a TGF-β1 responsive gene and its involvement in negative regulation of cell growth. Reviewed International journal

    80 ( 5 )   465 - 472   2002.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1006/geno.2002.6860

  • Suppressed tumorigenicity of human endometrial cancer cells by the restored expression of DCC gene. Reviewed International journal

    Kato H, Zhou Y, Asanoma K, Kondo H, Yoshikawa Y, Watanabe K, Matsuda T, Wake N and Barrett JC

    British Journal of Cancer   82 ( 2 )   459 - 466   2000.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1054/bjoc.1999.0943

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Books

  • 胎盤の基礎と診療・絨毛細胞の分化機構

    福嶋恒太郎、浅野間和夫、和氣徳夫( Role: Joint author)

    産科と婦人科  2011.6 

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    Responsible for pages:巻:74 号:7 頁:775-781   Language:Japanese   Book type:Scholarly book

  • 絨毛癌の分子機構

    浅野間和夫、松田貴雄、和氣徳夫( Role: Edit)

    中山書店  2002.1 

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    Responsible for pages:41巻423-432ページ   Language:Japanese   Book type:Scholarly book

Presentations

  • BHLHE40 regulates glycolysis and oxidative phosphorylation in endometrial cancer cells.

    Asanoma Kazuo, Yagi Hiroshi, Onoyama Ichiro, Yoshida Sacihko, Kodama Keisuke, Kawakami Minoru, Tomonobe Hiroshi, Yasutake Nobuko, Yasunaga Masafumi, Ohgami Tatsuhiro, Okugawa Kaoru, Yahata Hideaki, Kato Kiyoko

    2021.4 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Transcriptional factors, DEC1 and DEC2 cooperatively regulate epithelial-to-mesenchymal transition of uterine endometrial cancer cells.

    Kazuo Asanoma, Hiroaki Kobayashi, Norio Wake, Kiyoko Kato.

    2014.4 

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    Event date: 2021.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Basic HLH type of transcriptional factors, DEC1 and DEC2 suppress epithelial-to-mesenchymal transition of uterine endometrial cancer cells.

    Kazuo Asanoma, Takako Yamane, Kenzo Sonoda, Norio Wake, Kiyoko Kato

    2015.4 

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    Event date: 2021.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Basic HLH type of transcriptional factors, BHLHE40 and BHLHE41 suppress epithelial-to-mesenchymal transition of endometrial cancer cells by inhibiting SP1 function.

    Kazuo Asanoma, Takako Ohmaru, Kenzo Sonoda, Norio Wake, Kiyoko Kato

    2016.4 

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    Event date: 2021.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • BHLHE40 and BHLHE41 suppress epithelial-to-mesenchymal transition of uterine endometrial cancer cells by inhibiting SP1 function.

    Asanoma kazuo, Sonoda kenzo, Kato kiyoko

    2016.7 

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    Event date: 2021.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • The MIR130 families suppress epithelial-to-mesenchymal transition of uterine endometrial cancer cells by inhibiting the expression of BHLHE40 and BHLHE41.

    Kazuo Asanoma, Hiroshi Yagi, Ichiro Onoyama, Kenzo Sonoda, Kiyoko Kato

    2017.4 

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    Event date: 2021.5

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • The MIR130 families suppress epithelial-to-mesenchymal transition of uterine endometrial cancer cells by inhibiting the expression of BHLHE40 and BHLHE41.

    Kazuo Asanoma, Hiroshi Yagi, Ichiro Onoyama, Kenzo Sonoda, Kiyoko Kato

    2017.7 

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    Event date: 2021.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Mutual regulation between MIR301B-MIR130B and BHLHE40-BHLHE41 is involved in epithelial-to-mesenchymal transition of uterine endometrial cancer cells. International conference

    Kazuo Asanoma, Hiroshi Yagi, Ichirou Onoyama, Kenzo Sonoda, Kiyoko Kato

    17th Biennial Meeting of the International Gynecologic Cancer Society  2018.9 

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    Event date: 2021.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Mutual regulation between MIR301B-MIR130B and BHLHE40-BHLHE41 is involved in epithelial-to-mesenchymal transition of uterine endometrial cancer cells.

    Kazuo Asanoma, Hiroshi Yagi, Ichirou Onoyama, Kenzo Sonoda, Kiyoko Kato

    2019.4 

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    Event date: 2021.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Transcriptional regulation by BHLHE40/BHLHE41 and SP1 is involved in the expression of oncogenic microRNAs, MIR301B and MIR130B, in uterine endometrial cancer cells.

    Kazuo Asanoma, Hiroshi Yagi, Ichirou Onoyama, Keisuke Kodama, Masafumi Yasunaga, Tatsuhiro Ohgami, Nobuko Yasutake, Masako Kijima, Eisuke Kaneki, Kaoru Okugawa, Hideaki Yahata, Kiyoko Kato

    2020.4 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Transcriptional regulation of oncogenic microRNAs, MIR301B and MIR130B by BHLHE40/BHLHE41 and SP1 is involved in uterine endometrial cancer cells.

    Asanoma kazuo, Yagi Hiroshi, Onoyama Ichiro, Kodama Keisuke, Kijima Masako, Yasutake Nobuko, Yasunaga Masafumi, Ohgami Tatsuhiro, Kenjo Hironori, Okugawa Kaoru, Yahata Hideaki, Kato Kiyoko

    2021.1 

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    Event date: 2021.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Regulation of trophoblast differentiation by nuclear matrix associated gene, Satb1 and Satb2 International conference

    Asanoma Kazuo, Kubota Kaiyu, Chakraborty Damayanti, Stephen J. Renaud, Wake Norio, Kotaro Fukushima, Michael J. Soares, M. A. Karim Rumi

    International Federation of Placenta Association Meeting 2012  2012.9 

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    Event date: 2021.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  • ダイオキシン受容体は一塩基多型依存的に転写制御され、子宮体癌の増殖・浸潤に関わる

    淺野間 和夫, 髙尾 知佳, 恒松 良祐, 諸隈 誠一, 福嶋恒太郎, 小林 裕明, 齋藤俊章, 加藤 聖子, 和氣徳夫

    第54回日本婦人科腫瘍学会学術講演会  2013.7 

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    Event date: 2013.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • ダイオキシン受容体は一塩基多型依存的に転写制御され、子宮体癌の増殖・浸潤に関わる

    淺野間 和夫, 髙尾 知佳, 恒松 良祐, 諸隈 誠一, 福嶋恒太郎, 小林 裕明, 齋藤俊章, 加藤 聖子, 和氣徳夫

    第12回に本婦人科がん分子標的研究会学術集会  2013.7 

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    Event date: 2013.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:奈良   Country:Japan  

  • 転写因子NF1Cは一塩基多型依存的にダイオキシン受容体の転写を抑制し、子宮内膜癌の増殖・浸潤を制御する

    淺野間 和夫, 恒松 良祐, 諸隈 誠一, 福嶋 恒太郎, 小林 裕明, 齋藤 俊章, 加藤 聖子, 和氣 徳夫

    第65回日本産婦人科学会学術講演会  2013.5 

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    Event date: 2013.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  • マウス栄養膜細胞の分化を制御する新たな分子、核マトリックス関連分子Satb1, Satb2の解析

    浅野間和夫、福嶋恒太郎、和氣徳夫

    日本産科婦人科学会第64回学術講演会  2012.4 

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    Event date: 2012.4

    Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  • Establishment of trophoblast cell lines from rat blastocysts possessing the capacity to differentiate into multiple trophoblast cell lineage

    63th Annual Congress of the Japan Society of Obstetrics and Gynecology  2011.8 

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    Event date: 2011.8

    Presentation type:Oral presentation (general)  

    Country:Japan  

  • Isolation of stem cells from rat blastocysts possessing the capacity to differentiate along the trophoblast cell lineage International conference

    Asanoma K, Lee Dong-Soo, Soares Michael J

    The 5th annual Gilberts S Greenwald Symposium on Reproduction  2008.2 

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    Event date: 2011.2

    Presentation type:Oral presentation (general)  

    Country:United States  

    Other Link: http://www2.kumc.edu/crs/greenwald/index.html

  • ラット栄養膜幹細胞株樹立の試み

    浅野間和夫、和氣徳夫、Dong-Soo Lee, Lindsey N. Kent, M.A. Karim Rumi and Michael J. Soares

    第18回日本胎盤学会学術集会  2010.9 

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    Event date: 2010.9 - 2010.10

    Presentation type:Oral presentation (general)  

    Venue:熊本市   Country:Japan  

  • Isolation of stem cells from rat blastocysts possessing the capacity to differentiate along the trophoblast cell lineage International conference

    Asanoma K, Lee Dong-Soo, Soares Michael J

    International Society of Stem Cell Research (ISSCR) 6th annual meeting  2008.6 

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    Event date: 2008.6 - 2011.6

    Presentation type:Oral presentation (general)  

    Country:United States  

    Other Link: http://www.isscr.org/

  • ホメオボックス遺伝子NECC1のマウス栄養膜細胞における働き

    浅野間和夫、加藤聖子、和氣徳夫

    第59回 日本産科婦人科学会総会学術講演会  2007.4 

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    Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • 母親相互転座に関与した20番短腕トリソミー・10番長腕モノソミーの症例

    浅野間和夫、松田貴雄、加藤秀則、近藤晴彦、和氣徳夫

    第52回日本産科婦人科学会九州連合地方部会  1998.1 

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    Presentation type:Oral presentation (general)  

    Venue:大分   Country:Japan  

  • 胎盤特異的cDNAライブラリーの作成

    浅野間和夫、松田貴雄、近藤晴彦、加藤秀則、和氣徳夫

    第3回日本産婦人科腫瘍マーカー・遺伝子診断学会  1999.2 

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    Presentation type:Oral presentation (general)  

    Venue:佐賀市   Country:Japan  

  • 胎盤特異的cDNAライブラリーの作成

    浅野間和夫、松田貴雄、近藤晴彦、加藤秀則、和氣徳夫

    第51回 日本産科婦人科学会学術講演会  1999.4 

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    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 卵管通過障害に対して卵管鏡下卵管形成術を施行した15症例の検討

    浅野間和夫、松田貴雄、栗秋ユミ子、加藤秀則、和氣徳夫

    第50回 日本母性保護産婦人科医会九州ブロック会学術講演会  1999.5 

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    Presentation type:Oral presentation (general)  

    Venue:佐賀   Country:Japan  

  • 卵管通過障害に対して卵管鏡下卵管形成術を施行した15症例の検討

    浅野間和夫、松田貴雄、栗秋ユミ子、加藤秀則、和氣徳夫

    第11回 大分内視鏡下外科手術研究会  1999.6 

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    Presentation type:Oral presentation (general)  

    Venue:大分   Country:Japan  

  • 絨毛癌抑制に関わる遺伝子の単離

    浅野間和夫、松田貴雄、近藤晴彦、小川昌宣、周 勇、加藤秀則、和気徳夫

    第52回 日本産科婦人科学会学術講演会  2000.4 

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    Presentation type:Oral presentation (general)  

    Venue:徳島   Country:Japan  

  • 高インスリン血症を呈する不妊患者に対するインスリン抵抗性改善薬の効果の検討

    浅野間和夫、松田貴雄、近藤晴彦、小川昌宣、加藤秀則、和氣徳夫

    第11回 日本不妊学会春季九州支部会  2000.4 

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    Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • Construction of placenta specific cDNA library. International conference

    Asanoma K, Matsuda T, Kondoh H, Ogawa M, Zhou Y, Kato H, Nakano H, Wake N

    AOCOG 2000  2000.7 

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    Presentation type:Oral presentation (general)  

    Country:Singapore  

  • 多嚢胞卵巣症候群に対するインスリン抵抗性改善メトフォルミンの使用経験

    浅野間和夫、松田貴雄、近藤晴彦、加藤秀則、和氣徳夫

    第45回 日本不妊学会  2000.11 

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    Presentation type:Oral presentation (general)  

    Venue:神戸   Country:Japan  

  • 排卵障害を伴う不妊患者のインスリン抵抗性の評価と改善薬の使用経験

    浅野間和夫、松田貴雄、近藤晴彦、加藤秀則、和氣徳夫

    第58回 日本産科婦人科学会九州連合地方部会  2001.10 

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    Presentation type:Oral presentation (general)  

    Venue:久留米   Country:Japan  

  • 絨毛癌の癌抑制に関わる新規候補遺伝子の報告

    浅野間和夫、松田貴雄、近藤晴彦、周勇、加藤秀則、和氣徳夫

    第19回 絨毛性疾患研究会  2001.10 

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    Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • 絨毛癌の癌化抑制および絨毛分化に関わる新規候補遺伝子NECC1

    浅野間和夫、松田貴雄、近藤晴彦、加藤秀則、和氣徳夫

    第54回 日本産科婦人科学会学術講演会  2002.4 

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    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 多嚢胞性卵巣症候群患者に対するインスリン抵抗性改善の試み〜薬物療法と温泉運動療法のインスリン抵抗性改善効果の比較

    浅野間和夫、松田貴雄、和氣徳夫

    第47回 日本不妊学会学術講演会  2002.10 

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    Presentation type:Oral presentation (general)  

    Venue:岐阜   Country:Japan  

  • 絨毛癌の癌化抑制および絨毛分化に関わる新規候補遺伝子NECC1の解析

    浅野間和夫、松田貴雄、加藤秀則、和氣徳夫

    第55回 日本産科婦人科学会学術講演会  2003.4 

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    Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • Analysis of a candidate gene which is associated with growth suppression of choriocarcinoma and differentiation of trophoblasts. International conference

    K. Asanoma, T. Matsuda, H. Kato, H. Kondo, T. Inoue and N. Wake

    XIIth World congress on gestational trophoblastic diseases.  2003.10 

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    Presentation type:Oral presentation (general)  

    Country:United States  

  • 絨毛癌抑制および絨毛分化に関わるNECC1の解析

    浅野間和夫、加藤秀則、井上貴史、松田貴雄、和氣徳夫

    第20回 日本絨毛性疾患研究会  2003.11 

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    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 造腫瘍能抑制効果をもつNECC1遺伝子の胎盤形成における働き

    浅野間和夫、加藤秀則、松田貴雄、井上貴史、和氣徳夫

    第56回日本産科婦人科学会学術講演会  2004.4 

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    Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • Necc1遺伝子の栄養膜細胞分化・胎盤形成における働き

    浅野間和夫、加藤秀則、松田貴雄、井上貴史、山口真一郎、和氣徳夫

    第57回日本産科婦人科学会学術講演会  2005.4 

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    Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • マウス栄養膜細胞の分化、胎盤形成に関わる遺伝子NECC1の解析

    浅野間和夫、加藤秀則、和氣徳夫

    第13回日本胎盤学会  2005.10 

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    Presentation type:Oral presentation (general)  

    Venue:富山   Country:Japan  

  • 子宮体癌の癌化機構におけるNECC1遺伝子の関与

    浅野間和夫、山口真一郎、加藤聖子、大神達寛、和氣徳夫

    第58回日本産婦人科学会学術講演会  2006.4 

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    Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • 子宮内膜癌の癌化機構におけるNECC1遺伝子の関与

    浅野間和夫 加藤聖子 和氣徳夫

    第65回 日本癌学会学術総会  2006.9 

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    Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

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MISC

  • Establishment of a new diagnostic method for hydropic villi by using TSSC3 antibody

    Journal of Obstetrics and Gynecology Research   2013.6

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Trophoblast stem cells derived from nuclear transfer embryos: phenotypically unique, bad neighbors, or poor communicators?

    Soares MJ, Asanoma K

    Proc Natl Acad Sci U S A   2009.2

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 特集 胎盤の基礎と臨床 絨毛細胞の分化機構

    福嶋 恒太郎, 淺野間 和夫, 和氣 徳夫

    産科と婦人科/診断と治療社   2007.7

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 癌遺伝子治療への臨床応用

    浅野間和夫、加藤秀則、和氣徳夫

    2002.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

Professional Memberships

  • 日本人類遺伝学会

  • 日本産婦人科学会

  • The American Society for Biochemistry and Molecular Biology

  • International Society for Stem Cell Research

  • 日本婦人科腫瘍学会

Committee Memberships

  • Councilor   Domestic

    2012.6 - 2021.6   

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:14

  • Screening of academic papers

    Role(s): Peer review

    2019

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:12

  • Screening of academic papers

    Role(s): Peer review

    2018

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:15

  • Screening of academic papers

    Role(s): Peer review

    2017

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:11

  • Screening of academic papers

    Role(s): Peer review

    2016

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:7

  • Screening of academic papers

    Role(s): Peer review

    2015

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:3

  • Screening of academic papers

    Role(s): Peer review

    2014

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

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Research Projects

  • 子宮体癌細胞の上皮間葉移行を介した浸潤能に関わる代謝調節機構の解明

    Grant number:21K09519  2021 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • マイクロRNAを介した子宮体癌の進展制御を司る新たな分子機構の解明

    Grant number:17K11280  2017 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 転写調節機構から見た子宮体癌の浸潤・転移機構を司る新たな分子機構の解明

    Grant number:26462529  2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 子宮体癌の増殖浸潤を制御する新たな分子機構の解明と治療法の開発

    2013 - 2015

    武田科学振興財団 研究奨励費

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    Authorship:Principal investigator  Grant type:Contract research

  • 産科ストレスの視点から見た胎盤機能不全における絨毛細胞機能障害機構の解明

    Grant number:23591596  2011 - 2013

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • マウス胎盤形成に関わる核マトリックス関連蛋白Satbの解析

    Grant number:23592405  2011 - 2013

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 転写因子SRFを中心とするマウス栄養膜細胞の新たな分化調節機構の解明

    Grant number:19791154  2007 - 2008

    科学研究費助成事業  若手研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 栄養膜細胞の分化を制御し、胎盤形成に関わる新規遺伝子NECC1の解析

    2006

    神澤医学研究財団研究助成金

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • 胎盤形成を制御し、癌抑制機能をもつ新規遺伝子NECC1の解析

    Grant number:17791124  2005 - 2006

    科学研究費助成事業  若手研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 絨毛癌抑制遺伝子の単離

    2001 - 2003

    日本学術振興会  特別研究員

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    Authorship:Principal investigator  Grant type:Joint research

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Educational Activities

  • Bedside education for medical students
    Bedside education for resident physicians
    Bedside education for internship medical doctors
    Giving lectures for medical students

Class subject

  • 医学総合講義「生殖と免疫」

    2020.10 - 2021.3   Second semester

  • 医学総合講義「生殖と免疫」

    2019.10 - 2020.3   Second semester

  • 医学総合講義「生殖と免疫」

    2018.10 - 2019.3   Second semester

  • 医学総合講義「生殖と免疫」

    2013.10 - 2014.3   Second semester

  • 医学部6年生臨床医学実習

    2013.4 - 2014.3   Full year

  • 受胎・成長・発達

    2013.4 - 2013.9   First semester

  • 医学総合講義「生殖と免疫」

    2012.10 - 2013.3   Second semester

  • 医学部5年生臨床医学実習

    2012.4 - 2013.3   Full year

  • 受胎・成長・発達

    2012.4 - 2012.9   First semester

  • 医学総合講義「生殖と免疫」

    2011.10 - 2012.3   Second semester

  • 医学部5年生臨床医学実習

    2011.4 - 2012.3   Full year

  • 受胎・成長・発達

    2011.4 - 2011.9   First semester

  • 医学総合講義「生殖と免疫」

    2010.10 - 2011.3   Second semester

  • 医学部5年生臨床医学実習

    2010.4 - 2011.3   Full year

  • 助産診断技術学

    2010.4 - 2010.9   First semester

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Travel Abroad

  • 2007.9 - 2010.3

    Staying countory name 1:United States   Staying institution name 1:Kansas University Medical Center

  • 2003.2

    Staying countory name 1:United States   Staying institution name 1:Southwestern Medical Center, Texas Univeristy

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Surgical Clinical Medicine / Obstetrics and Gynecology

Clinician qualification

  • Specialist

    Japan Society of Obstetrics and Gynecology(JSOG)

Year of medical license acquisition

  • 1996

Notable Clinical Activities

  • 当科ならびに多施設臨床研究に協力している