Updated on 2024/10/07

Information

 

写真a

 
torisu kumiko
 
Organization
Faculty of Medical Sciences Associate Professor
Title
Associate Professor
Tel
0926425256
Profile
Clinical medicine, I meet outpatients twice a week and participate in treatment of inpatients through conference and round. Basic research, I teach several graduate students. My research interests include autophagy, arginine metabolism and renal disease. For medical students, I provide lectures in clinical medicine, including bedside and clinical clerkships,
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Research Areas

  • Life Science / Nephrology

Degree

  • M.D. Ph.D.

Research History

  • 九州大学大学院 医学研究院 包括的腎不全治療学 准教授

    2018.4 - Present

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    Country：Japan

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  • なし

    なし

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Research Interests・Research Keywords

  • Research theme：arginine metabolism, spermidine, acrolein, autophagy

    Keyword：arginine metabolism, spermidine, acrolein, autophagy

    Research period： 2024

  • Research theme：A role of autophagy in uptaking of albumin in renal tubular cells

    Keyword：autophagy, kidney

    Research period： 2016.9 - 2018.3

  • Research theme：Role of PKCeta and Arg2 in kidney injury

    Keyword：PKCeta, Arg2, kidney, Nitric oxide

    Research period： 2015.10 - 2019.3

  • Research theme：Role of NOX4 in kidney injury model mouse

    Keyword：NOX4, endothelial cells, kidney diseases

    Research period： 2014.4 - 2018.3

  • Research theme：Role of autophagy in collagen secretion from mesangial cells under nephropathy

    Keyword：autophagy, mesangial cells, collagen

    Research period： 2013.9 - 2016.3

  • Research theme：Role of autophagy in cardiovascular or kidney diseases

    Keyword：autophagy, vasucular diseases, kidney diseases

    Research period： 2013.4 - 2017.3

Awards

  • 日本女性腎臓病医の会(JSWN)研究活動奨励賞

    2017.2   日本城西腎臓病医の会(JSWN)   尿細管のアルブミン再吸収におけるオートファジーの役割

  • 研究活動奨励賞

    2016.6   日本女性腎臓病医の会   尿細管のアルブミン再吸収におけるオートファジーの役割

Papers

  • Arginase 2 Promotes Cisplatin-Induced Acute Kidney Injury by the Inflammatory Response of Macrophages. Reviewed International journal

    Yushi Uchida, Kumiko Torisu, Seishi Aihara, Noriyuki Imazu, Hiroaki Ooboshi, Takanari Kitazono, Toshiaki Nakano

    Laboratory investigation; a journal of technical methods and pathology   103 ( 10 )   100227 - 100227   2023.8   （ ISSN:0023-6837 eISSN:1530-0307 ）

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    Acute kidney injury (AKI) is a complex clinical syndrome with a rapid decrease in renal function caused by several different etiologies, including sepsis, ischemia, and the administration of nephrotoxic drugs. Tubular arginase 2 (ARG2), an arginine-metabolic enzyme, is a potential therapeutic target for AKI, but it has not been confirmed under various AKI conditions. The aim of this study was to investigate ARG2 as a therapeutic target for cisplatin-induced AKI. Cisplatin-treated mice with a genetic deficiency in Arg2 had significant amelioration of renal dysfunction, characterized by decreased acute tubular damage and apoptosis. In contrast, cisplatin-induced tubular toxicity was not ameliorated in proximal tubule cells derived from Arg2-deficient mice. Immunohistochemical analysis demonstrated the increased infiltration of ARG2-positive macrophages in kidneys damaged by cisplatin. Importantly, cisplatin-treated Arg2 knockout mice exhibited a significant reduction in kidney inflammation, characterized by the decreased infiltration of inflammatory macrophages and reduced gene expression of interleukin (IL)-6 and IL-1β. The secretion of IL-6 and IL-1β induced by lipopolysaccharides was decreased in bone marrow-derived macrophages isolated from Arg2-deficient mice. Furthermore, the lipopolysaccharide-induced elevation of mitochondrial membrane potential and production of reactive oxygen species were reduced in bone marrow-derived macrophages lacking Arg2. These findings indicate that ARG2 promotes the inflammatory responses of macrophages through mitochondrial reactive oxygen species, resulting in the exacerbation of AKI. Therefore, targeting ARG2 in macrophages may constitute a promising therapeutic approach for AKI.

    DOI： 10.1016/j.labinv.2023.100227

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  • Spermidine from arginine metabolism activates Nrf2 and inhibits kidney fibrosis. Reviewed International journal

    Seishi Aihara, Kumiko Torisu, Yushi Uchida, Noriyuki Imazu, Toshiaki Nakano, Takanari Kitazono

    Communications biology   6 ( 1 )   676 - 676   2023.6   （ eISSN:2399-3642 ）

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    Kidney metabolism may be greatly altered in chronic kidney disease. Here we report that arginine metabolism is the most altered in unilateral ureteral obstruction (UUO)-induced fibrosis of the kidneys in metabolomic analysis. Spermidine is the most increased metabolite of arginine. In human glomerulonephritis, the amount of spermidine shown by immunostaining is associated with the amount of fibrosis. In human proximal tubule cells, spermidine induces nuclear factor erythroid 2-related factor 2 (Nrf2). Subsequently, fibrotic signals, such as transforming growth factor β1 secretion, collagen 1 mRNA, and oxidative stress, represented by a decrease in the mitochondrial membrane potential is suppressed by spermidine. UUO kidneys of Arg2 knockout mice show less spermidine and significantly exacerbated fibrosis compared with wild-type mice. Nrf2 activation is reduced in Arg2 knockout UUO kidneys. Spermidine treatment prevents significant fibrotic progression in Arg2 knockout mice. Spermidine is increased in kidney fibrosis, but further increases in spermidine may reduce fibrosis.

    DOI： 10.1038/s42003-023-05057-w

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  • Spermidine from arginine metabolism activates Nrf2 and inhibits kidney fibrosis Reviewed International journal

    #Seishi Aihara, @Kumiko Torisu, #Yushi Uchida, #Noriyuki Imazu, @Toshiaki Nakano, @Takanari Kitazono

    Communications Biology   6 ( 1 )   676   2023.6

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    DOI： https://doi.org/10.1038/s42003-023-05057-w

  • Autophagy gene ATG7 regulates albumin transcytosis in renal tubule epithelial cells Reviewed International journal

    #Yushi Uchida, @Kumiko Torisu, @Kenji Ueki, Kazuhiko Tsuruya, @Toshiaki Nakano, @Takanari Kitazono

    American Journal of Physiology-Renal Physiology   321 ( 5 )   F572 - F586   2021.11

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    DOI： 10.1152/ajprenal.00172.2021

  • Autophagy gene ATG7 regulates albumin transcytosis in renal tubule epithelial cells. International journal

    Yushi Uchida, Kumiko Torisu, Kenji Ueki, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    American journal of physiology. Renal physiology   321 ( 5 )   F572-F586   2021.11

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    DOI： 10.1152/ajprenal.00172.2021

  • Arginase 2 is a mediator of ischemia-reperfusion injury in the kidney through regulation of nitrosative stress. International journal

    Masatoshi Hara, Kumiko Torisu, Keigo Tomita, Yasuhiro Kawai, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    Kidney international   98 ( 3 )   673 - 685   2020.9

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    DOI： 10.1016/j.kint.2020.03.032

  • Arginase 2 is a mediator of ischemia–reperfusion injury in the kidney through regulation of nitrosative stress Reviewed International journal

    98 ( 3 )   673 - 685   2020.9

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    Kidney ischemia–reperfusion injury is a major cause of acute kidney injury (AKI). Following reduced kidney perfusion, the pathological overproduction of reactive oxygen and reactive nitrogen species play a substantial role in the development of kidney ischemia–reperfusion injury. Arginase 2 (ARG2) competes with nitric oxide synthase for the same substrate, L-arginine, and is implicated in the regulation of reactive nitrogen species. Therefore, we investigated the role of ARG2 in kidney ischemia–reperfusion injury using human proximal tubule cells (HK-2) and a mouse model of kidney ischemia–reperfusion injury. ARG2 was predominantly expressed in kidney tubules of the cortex, which was increased after ischemia–reperfusion injury. In HK-2 cells, ARG2 was expressed in punctate form in the cytoplasm and upregulated after hypoxia–reoxygenation. ARG2 knockdown reduced the level of reactive oxygen species and 3-nitrotyrosine after hypoxia–reoxygenation injury compared with control siRNA. Consistent with these results, in Arg2 knockout mice, abnormal kidney function and the increased acute tubular necrosis score induced by ischemia–reperfusion injury was significantly reduced without any obvious blood pressure changes. Additionally, an accumulation of 3-nitrotyrosine and apoptosis of renal tubule cells were attenuated in Arg2 knockout mice compared with wild-type mice. Inhibition of arginase by Nω-hydroxy-nor-L-arginine alleviated kidney ischemia–reperfusion injury like the results found in Arg2 knockout mice. Thus, ARG2 plays a pivotal role in ischemia–reperfusion-induced AKI by means of nitrosative stress. Hence, an ARG2-specific inhibitor may effectively treat kidney ischemia–reperfusion injury.

    DOI： 10.1016/j.kint.2020.03.032

  • PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice. International journal

    21 ( 10 )   1030 - 1048   2016.10

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    Genomewide association studies have shown that a nonsynonymous single nucleotide polymorphism in PRKCH is associated with cerebral infarction and atherosclerosis-related complications. We examined the role of PKCη in lipid metabolism and atherosclerosis using apolipoprotein E-deficient (Apoe-/- ) mice. PKCη expression was augmented in the aortas of mice with atherosclerosis and exclusively detected in MOMA2-positive macrophages within atherosclerotic lesions. Prkch+/+ Apoe-/- and Prkch-/- Apoe-/- mice were fed a high-fat diet (HFD), and the dyslipidemia observed in Prkch+/+ Apoe-/- mice was improved in Prkch-/- Apoe-/- mice, with a particular reduction in serum LDL cholesterol and phospholipids. Liver steatosis, which developed in Prkch+/+ Apoe-/- mice, was improved in Prkch-/- Apoe-/- mice, but glucose tolerance, adipose tissue and body weight, and blood pressure were unchanged. Consistent with improvements in LDL cholesterol, atherosclerotic lesions were decreased in HFD-fed Prkch-/- Apoe-/- mice. Immunoreactivity against 3-nitrotyrosine in atherosclerotic lesions was dramatically decreased in Prkch-/- Apoe-/- mice, accompanied by decreased necrosis and apoptosis in the lesions. ARG2 mRNA and protein levels were significantly increased in Prkch-/- Apoe-/- macrophages. These data show that PKCη deficiency improves dyslipidemia and reduces susceptibility to atherosclerosis in Apoe-/- mice, showing that PKCη plays a role in atherosclerosis development.

    DOI： 10.1111/gtc.12402

  • PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice Reviewed

    21 ( 10 )   1030 - 1048   2016.10

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    Genomewide association studies have shown that a nonsynonymous single nucleotide polymorphism in PRKCH is associated with cerebral infarction and atherosclerosis-related complications. We examined the role of PKCη in lipid metabolism and atherosclerosis using apolipoprotein E-deficient (Apoe−/−) mice. PKCη expression was augmented in the aortas of mice with atherosclerosis and exclusively detected in MOMA2-positive macrophages within atherosclerotic lesions. Prkch+/+Apoe−/− and Prkch−/−Apoe−/− mice were fed a high-fat diet (HFD), and the dyslipidemia observed in Prkch+/+Apoe−/− mice was improved in Prkch−/−Apoe−/− mice, with a particular reduction in serum LDL cholesterol and phospholipids. Liver steatosis, which developed in Prkch+/+Apoe−/− mice, was improved in Prkch−/−Apoe−/− mice, but glucose tolerance, adipose tissue and body weight, and blood pressure were unchanged. Consistent with improvements in LDL cholesterol, atherosclerotic lesions were decreased in HFD-fed Prkch−/−Apoe−/− mice. Immunoreactivity against 3-nitrotyrosine in atherosclerotic lesions was dramatically decreased in Prkch−/−Apoe−/− mice, accompanied by decreased necrosis and apoptosis in the lesions. ARG2 mRNA and protein levels were significantly increased in Prkch−/−Apoe−/− macrophages. These data show that PKCη deficiency improves dyslipidemia and reduces susceptibility to atherosclerosis in Apoe−/− mice, showing that PKCη plays a role in atherosclerosis development.

    DOI： 10.1111/gtc.12402

  • Intact endothelial autophagy is required to maintain vascular lipid homeostasis. International journal

    Kumiko Torisu, Krishna K Singh, Takehiro Torisu, Fina Lovren, Jie Liu, Yi Pan, Adrian Quan, Azza Ramadan, Mohammed Al-Omran, Natalie Pankova, Shelley R Boyd, Subodh Verma, Toren Finkel

    Aging cell   15 ( 1 )   187 - 91   2016.2

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    DOI： 10.1111/acel.12423

  • Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor. International journal

    Takehiro Torisu, Kumiko Torisu, In Hye Lee, Jie Liu, Daniela Malide, Christian A Combs, Xufeng S Wu, Ilsa I Rovira, Maria M Fergusson, Roberto Weigert, Patricia S Connelly, Mathew P Daniels, Masaaki Komatsu, Liu Cao, Toren Finkel

    Nature medicine   19 ( 10 )   1281 - 7   2013.10

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    DOI： 10.1038/nm.3288

  • Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor Reviewed

    @takehiro torisu, kumiko torisu, In Hye Lee, Jie Liu, Daniela Malide, Christian A. Combs, Xufeng S. Wu, Ilsa I. Rovira, Maria M. Fergusson, Roberto Weigert, Patricia S. Connelly, Mathew P. Daniels, Masaaki Komatsu, Liu Cao, Toren Finkel

    Nature medicine   19 ( 10 )   1281 - 1287   2013.10

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    DOI： 10.1038/nm.3288

  • Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein Reviewed

    Kumiko Torisu, Daisuke Tsuchimoto, Yoshinori Ohnishi, Yusaku Nakabeppu

    Journal of biochemistry   138 ( 6 )   763 - 772   2005.12

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    DOI： 10.1093/jb/mvi168

  • SGLT2 inhibition mitigates transition from acute kidney injury to chronic kidney disease by suppressing ferroptosis Reviewed International journal

    Hirashima, Y; Nakano, T; Torisu, K; Aihara, S; Wakisaka, M; Kitazono, T

    SCIENTIFIC REPORTS   14 ( 1 )   20386   2024.9   （ ISSN:2045-2322 ）

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    Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been shown to be renoprotective in ischemia-reperfusion (I/R) injury, with several proposed mechanisms, though additional mechanisms likely exist. This study investigated the impact of luseogliflozin on kidney fibrosis at 48 h and 1 week post I/R injury in C57BL/6 mice. Luseogliflozin attenuated kidney dysfunction and the acute tubular necrosis score on day 2 post I/R injury, and subsequent fibrosis at 1 week, as determined by Sirius red staining. Metabolomics enrichment analysis of I/R-injured kidneys revealed suppression of the glycolytic system and activation of mitochondrial function under treatment with luseogliflozin. Western blotting showed increased nutrient deprivation signaling with elevated phosphorylated AMP-activated protein kinase and Sirtuin-3 in luseogliflozin-treated kidneys. Luseogliflozin-treated kidneys displayed increased protein levels of carnitine palmitoyl transferase 1α and decreased triglyceride deposition, as determined by oil red O staining, suggesting activated fatty acid oxidation. Luseogliflozin prevented the I/R injury-induced reduction in nuclear factor erythroid 2-related factor 2 activity. Western blotting revealed increased glutathione peroxidase 4 and decreased transferrin receptor protein 1 expression. Immunostaining showed reduced 4-hydroxynonenal and malondialdehyde levels, especially in renal tubules, indicating suppressed ferroptosis. Luseogliflozin may protect the kidney from I/R injury by inhibiting ferroptosis through oxidative stress reduction.

    DOI： 10.1038/s41598-024-71416-0

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  • Vascular Calcification Is Accelerated by Hyponatremia and Low Osmolality. Reviewed International journal

    Matsueda Shumei, Shunsuke Yamada, Kumiko Torisu, Hiromasa Kitamura, Toshiharu Ninomiya, Toshiaki Nakano, Takanari Kitazono

    Arteriosclerosis, thrombosis, and vascular biology   44 ( 9 )   1925 - 1943   2024.9   （ ISSN:1079-5642 eISSN:1524-4636 ）

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    BACKGROUND: Hyponatremia, frequently observed in patients with chronic kidney disease, is associated with increased cardiovascular morbidity and mortality. Hyponatremia or low osmolality induces oxidative stress and cell death, both of which accelerate vascular calcification (VC), a critical phenotype in patients with chronic kidney disease. Whether hyponatremia or low osmolality plays a role in the pathogenesis of VC is unknown. METHODS: Human vascular smooth muscle cells (VSMCs) and mouse aortic rings were cultured in various osmotic conditions and calcifying medium supplemented with high calcium and phosphate. The effects of low osmolality on phenotypic change and oxidative stress in the cultured VSMCs were examined. Microarray analysis was conducted to determine the main signaling pathway of osmolality-related VC. The transcellular sodium and calcium ions flux across the VSMCs were visualized by live imaging. Furthermore, the effect of osmolality on calciprotein particles (CPPs) was investigated. Associations between arterial intimal calcification and hyponatremia or low osmolality were examined by a cross-sectional study using human autopsy specimens obtained in the Hisayama Study. RESULTS: Low osmolality exacerbated calcification of the ECM (extracellular matrix) of cultured VSMCs and mouse aortic rings. Oxidative stress and osteogenic differentiation of VSMCs were identified as the underlying mechanisms responsible for low osmolality-induced VC. Microarray analysis showed that low osmolality activated the Rac1 (Ras-related C3 botulinum toxin substrate 1)-Akt pathway and reduced NCX1 (Na-Ca exchanger 1) expression. Live imaging showed synchronic calcium ion efflux and sodium ion influx via NCX1 when extracellular sodium ion concentrations were increased. An NCX1 inhibitor promoted calcifying media-induced VC by reducing calcium ion efflux. Furthermore, low osmolality accelerated the generation and maturation steps of CPPs. The cross-sectional study of human autopsy specimens showed that hyponatremia and low osmolality were associated with a greater area of arterial intimal calcification. CONCLUSIONS: Hyponatremia and low osmolality promote VC through multiple cellular processes, including the Rac1-Akt pathway activation.

    DOI： 10.1161/ATVBAHA.123.320069

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  • 【Current evidence and perspectives for hypertension management in Asia】More rapid progression of brain atrophy in patients on peritoneal dialysis compared with hemodialysis: The VCOHP Study(タイトル和訳中) Reviewed International journal

    Tsuruya Kazuhiko, Yoshida Hisako, Yamada Shunsuke, Haruyama Naoki, Tanaka Shigeru, Tsuchimoto Akihiro, Eriguchi Masahiro, Fujisaki Kiichiro, Torisu Kumiko, Nakano Toshiaki, Masutani Kosuke, Kitazono Takanari

    Hypertension Research   47 ( 4 )   887 - 897   2024.4   （ ISSN:0916-9636 ）

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  • More rapid progression of brain atrophy in patients on peritoneal dialysis compared with hemodialysis: The VCOHP Study. International journal

    Kazuhiko Tsuruya, Hisako Yoshida, Shunsuke Yamada, Naoki Haruyama, Shigeru Tanaka, Akihiro Tsuchimoto, Masahiro Eriguchi, Kiichiro Fujisaki, Kumiko Torisu, Toshiaki Nakano, Kosuke Masutani, Takanari Kitazono

    Hypertension research : official journal of the Japanese Society of Hypertension   47 ( 3 )   790 - 793   2024.3   （ ISSN:0916-9636 eISSN:1348-4214 ）

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    We previously reported that brain atrophy was more severe and progressed more rapidly in patients with end-stage kidney disease on peritoneal dialysis (PD) than those with non-dialysis-dependent chronic kidney disease. However, it remains unknown whether there is a difference between patients on PD and hemodialysis (HD). In total, 73 PD and 34 HD patients who underwent brain magnetic resonance imaging (MRI) were recruited for a cross-sectional analysis. Among them, 42 PD and 25 HD patients who underwent a second brain MRI after 2 years were recruited for a longitudinal analysis. T1-weighted MRI images were analyzed. Total gray matter volume (GMV), total white matter volume, and cerebrospinal fluid volume were segmented, and each volume was quantified using statistical parametric mapping software. The ratio of GMV (GMR) was calculated by dividing GMV by intracranial volume, to adjust for variations in head size. We compared GMR between PD and HD patients in the cross-sectional analysis and the annual change in GMR (AC-GMR) in the longitudinal analysis. In the cross-sectional analysis, age- and sex-adjusted GMR was significantly lower in PD than HD patients [least square mean (LSM): 39.2% vs. 40.0%, P = 0.018]. AC-GMR was significantly greater in PD than HD patients and this difference remained significant even after adjustment for potential confounding factors (LSM: -0.68 vs. -0.28 percentage-points/year, P = 0.011). In conclusion, the present study demonstrated a more rapid progression of brain atrophy in PD patients compared with HD patients. We demonstrated that decline in GMR progressed significantly more rapidly in PD than HD patients independent of potential confounding factors. GMR gray matter volume ratio, HD hemodialysis, PD peritoneal dialysis.

    DOI： 10.1038/s41440-023-01530-5

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  • Magnesium inhibits peritoneal calcification as a late-stage characteristic of encapsulating peritoneal sclerosis. International journal

    Seishi Aihara, Shunsuke Yamada, Shumei Matsueda, Akinori Nagashima, Kumiko Torisu, Takanari Kitazono, Toshiaki Nakano

    Scientific reports   13 ( 1 )   16340 - 16340   2023.9   （ ISSN:2045-2322 ）

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    Peritoneal calcification is a prominent feature of the later stage of encapsulating peritoneal sclerosis (EPS) in patients undergoing long-term peritoneal dialysis (PD). However, the pathogenesis and preventive strategy for peritoneal calcification remain unclear. Peritoneum samples from EPS patients were examined histologically. Peritoneal calcification was induced in mice by feeding with an adenine-containing diet combined with intraperitoneal administration of lipopolysaccharide and a calcifying solution containing high calcium and phosphate. Excised mouse peritoneum, human mesothelial cells (MeT5A), and mouse embryonic fibroblasts (MEFs) were cultured in calcifying medium. Immunohistochemistry confirmed the appearance of osteoblastic differentiation-marker-positive cells in the visceral peritoneum from EPS patients. Intraperitoneal administration of magnesium suppressed peritoneal fibrosis and calcification in mice. Calcifying medium increased the calcification of cultured mouse peritoneum, which was prevented by magnesium. Calcification of the extracellular matrix was accelerated in Met5A cells and MEFs treated with calcification medium. Calcifying medium also upregulated osteoblastic differentiation markers in MeT5A cells and induced apoptosis in MEFs. Conversely, magnesium supplementation mitigated extracellular matrix calcification and phenotypic transdifferentiation and apoptosis caused by calcifying conditions in cultured MeT5A cells and MEFs. Phosphate loading contributes to the progression of EPS through peritoneal calcification and fibrosis, which can be prevented by magnesium supplementation.

    DOI： 10.1038/s41598-023-43657-y

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  • 腎障害とエネルギー・代謝研究の新たな展開 アルギニン代謝を通して腎保護を考える

    鳥巣 久美子, 相原 成志, 内田 裕士, 中野 敏昭

    日本腎臓学会誌   65 ( 6-W )   742 - 742   2023.9   （ ISSN:0385-2385 eISSN:1884-0728 ）

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  • Acrolein produced during acute kidney injury promotes tubular cell death. Reviewed International journal

    Seishi Aihara, Kumiko Torisu, Yutaro Hirashima, Takanari Kitazono, Toshiaki Nakano

    Biochemical and biophysical research communications   666   137 - 145   2023.7   （ ISSN:0006-291X eISSN:1090-2104 ）

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    Acute kidney injury is an important global health concern as it is associated with high morbidity and mortality. Polyamines, essential for cell growth and proliferation, are known to inhibit cardiovascular disease. However, under conditions of cellular damage, toxic acrolein is produced from polyamines by the enzyme spermine oxidase (SMOX). We used a mouse renal ischemia-reperfusion model and human proximal tubule cells (HK-2) to investigate whether acrolein exacerbates acute kidney injury by renal tubular cell death. Acrolein visualized by acroleinRED was increased in ischemia-reperfusion kidneys, particularly in tubular cells. When HK-2 cells were cultured under 1% oxygen for 24 h, then switched to 21% oxygen for 24 h (hypoxia-reoxygenation), acrolein accumulated and SMOX mRNA and protein levels were increased. Acrolein induced cell death and fibrosis-related TGFB1 mRNA in HK-2 cells. Administration of the acrolein scavenger cysteamine suppressed the acrolein-induced upregulation of TGFB1 mRNA. Cysteamine also inhibited a decrease in the mitochondrial membrane potential observed by MitoTrackerCMXRos, and cell death induced by hypoxia-reoxygenation. The siRNA-mediated knockdown of SMOX also suppressed hypoxia-reoxygenation-induced acrolein accumulation and cell death. Our study suggests that acrolein exacerbates acute kidney injury by promoting tubular cell death during ischemia-reperfusion injury. Treatment to control the accumulation of acrolein might be an effective therapeutic option for renal ischemia-reperfusion injury.

    DOI： 10.1016/j.bbrc.2023.05.029

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  • アルギナーゼ2はシスプラチン誘発急性腎障害においてマクロファージの炎症応答を促進する

    内田 裕士, 鳥巣 久美子, 相原 成志, 大星 博明, 中野 敏昭, 北園 孝成

    日本腎臓学会誌   65 ( 3 )   298 - 298   2023.5   （ ISSN:0385-2385 eISSN:1884-0728 ）

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  • Indoxyl sulfate induces left ventricular hypertrophy via the AhR-FGF23-FGFR4 signaling pathway. Reviewed International journal

    Hiroshi Kishimoto, Toshiaki Nakano, Kumiko Torisu, Masanori Tokumoto, Yushi Uchida, Shunsuke Yamada, Masatomo Taniguchi, Takanari Kitazono

    Frontiers in cardiovascular medicine   10   990422 - 990422   2023.2   （ ISSN:2297-055X ）

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    BACKGROUND: Patients with chronic kidney disease (CKD) have a high risk of left ventricular hypertrophy (LVH). Fibroblast growth factor 23 (FGF23) and indoxyl sulfate (IS) are associated with LVH in patients with CKD, but the interactions between these molecules remain unknown. We investigated whether IS contributes to LVH associated with FGF23 in cultured cardiomyocytes and CKD mice. METHODS AND RESULTS: In cultured rat cardiac myoblast H9c2 cells incubated with IS, mRNA levels of the LVH markers atrial natriuretic factor, brain natriuretic peptide, and β-myosin heavy chain were significantly upregulated. Levels of mRNA of the polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3), which regulates FGF23 O-glycosylation, and FGF23 were also upregulated in H9c2 cells. Intact FGF23 protein expression and fibroblast growth factor receptor 4 (FGFR4) phosphorylation were increased in cell lysates by IS administration. In C57BL/6J mice with heminephrectomy, IS promoted LVH, whereas the inhibition of FGFR4 significantly reduced heart weight and left ventricular wall thickness in IS-treated groups. While there was no significant difference in serum FGF23 concentrations, cardiac FGF23 protein expression was markedly increased in IS-injected mice. GALNT3, hypoxia-inducible factor 1 alpha, and FGF23 protein expression was induced in H9c2 cells by IS treatment and suppressed by the inhibition of Aryl hydrocarbon receptor which is the receptor for IS. CONCLUSION: This study suggests that IS increases FGF23 protein expression via an increase in GALNT3 and hypoxia-inducible factor 1 alpha expression, and activates FGF23-FGFR4 signaling in cardiomyocytes, leading to LVH.

    DOI： 10.3389/fcvm.2023.990422

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  • Indoxyl sulfate induces left ventricular hypertrophy via the AhR-FGF23-FGFR4 signaling pathway Reviewed International journal

    #Hiroshi Kishimoto, @Toshiaki Nakano, @Kumiko Torisu, Masanori Tokumoto, #Yushi Uchida, @Shunsuke Yamada, Masatomo Taniguchi, @Takanari Kitazono

    Frontiers in Cardiovascular Medicine   10   2023.2

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    DOI： https://doi.org/10.3389/fcvm.2023.990422

  • Glucose degradation products in peritoneal dialysis solution impair angiogenesis by dysregulating angiogenetic factors in endothelial and vascular smooth muscle cells.

    Seishi Aihara, Toshiaki Nakano, Kumiko Torisu, Takanari Kitazono

    Clinical and experimental nephrology   26 ( 12 )   1160 - 1169   2022.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10157-022-02272-3

  • 腹膜透析液中のグルコース分解物は血管内皮細胞と血管平滑筋細胞における血管新生因子の調節不全を介して血管新生を障害する(Glucose degradation products in peritoneal dialysis solution impair angiogenesis by dysregulating angiogenetic factors in endothelial and vascular smooth muscle cells) Reviewed

    Aihara Seishi, Nakano Toshiaki, Torisu Kumiko, Kitazono Takanari

    Clinical and Experimental Nephrology   26 ( 12 )   1160 - 1169   2022.12   （ ISSN:1342-1751 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：(一社)日本腎臓学会  

    血管内皮細胞と血管平滑筋細胞を用いたin vitro実験系において、腹膜透析液中のグルコース分解物(GDP)が血管新生に及ぼす影響について検討した。ヒト臍帯静脈内皮細胞(HUVEC)とヒト臍帯動脈平滑筋細胞(HUASMC)において、腹膜透析液に含まれる三つの主要なGDPであるメチルグリオキサール(MGO)、3-デオキシグルコソン(3-DG)、5-ヒドロキシメチルフルフラール(5-HMF)の作用を調べた。HUVECとHUASMCはリポポリサッカライド(LPS)で活性化したマウスマクロファージ細胞株の培養上清で刺激した。その結果、HUVECにおいて、血小板由来増殖因子B(PDGFB)のmRNAとタンパク質の発現は、腹膜透析液で観察される濃度のMGO、3-DG、5-HMFへの曝露により低下し、それに続いて分泌されるPDGF受容体βの減少が観察された。HUASMCでは、MGOと5-HMFにより血管内皮増殖因子A(VEGF-A)のmRNAとタンパク質の発現が増加し、5-HMFによりPDGF受容体βの発現が低下した。HUASMCでは、LPS刺激マクロファージの培養上清により、VEGF-Aの発現が亢進し、PDGF受容体βの発現は低下した。以上より、腹膜透析液中のGDPは、血管内皮細胞や血管平滑筋細胞における血管新生因子の不均衡を引き起こし、腹膜における未熟な血管新生を誘導する可能性が示された。

  • Current antihypertensive treatment and treatment-resistant hypertension in Japanese patients with chronic kidney disease

    Tsuchimoto A., Tanaka S., Kitamura H., Hiyamuta H., Tsuruya K., Kitazono T., Nakano T., Fujimi S., Hirakata H., Hirano T., Yoshida T., Deguchi T., Mitsuiki K., Fujisaki K., Tokumoto M., Nakai K., Nagashima A., Katafuchi R., Kanai H., Harada K., Mizumasa T., Ninomiya T., Torisu K., Yamada S., Matsuo D., Kuroki Y., Nagae H., Nakayama M., Nagata M., Yanagida T., Ohnaka S.

    Clinical and Experimental Nephrology   26 ( 11 )   1100 - 1110   2022.11   （ ISSN:13421751 ）

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    Publisher：Clinical and Experimental Nephrology  

    Background: Hypertension is an important prognostic predictor in patients with chronic kidney disease (CKD), and the recommended target blood pressure has been continuously revised. This study aimed to reveal the current antihypertensive practices in Japanese patients with CKD. Methods: In the Fukuoka Kidney disease Registry, we extracted 3664 non-dialysis-dependent patients with CKD. Apparent treatment-resistant hypertension (aTRH) was defined as a failure of blood-pressure control treated with three antihypertensive medication classes or a treatment with ≥ 4 classes regardless of blood pressure. The blood-pressure control complied with the target blood pressure recommended by the KDIGO 2012 guideline. Results: The median age of the patients was 67 years, body mass index (BMI) was 23 kg/m2, and estimated glomerular filtration rate (eGFR) was 40 mL/min/1.73 m2. The number of patients with unachieved blood-pressure control was 1933, of whom 26% received ≥ 3 classes of antihypertensive medications. The first choice of medication was renin–angiotensin system inhibitors, followed by calcium-channel blockers. The rate of thiazide use was low in all CKD stages (3–11%). The prevalence of aTRH was 16%, which was significantly associated with BMI (odds ratio [95% confidence interval] per 1-standard deviation change, 1.38 [1.25–1.53]), decreased eGFR (1.87 [1.57–2.23]), as well as age, diabetes mellitus, and chronic heart disease. Conclusions: Renal dysfunction and obesity are important risk factors of aTRH. Even under nephrologist care, most patients were treated with insufficient antihypertensive medications. It is important to prescribe sufficient classes of antihypertensive medications, including diuretics, and to improve patients’ lifestyle habits.

    DOI： 10.1007/s10157-022-02250-9

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  • Glucose degradation products in peritoneal dialysis solution impair angiogenesis by dysregulating angiogenetic factors in endothelial and vascular smooth muscle cells Reviewed International journal

    #Seishi Aihara, @Toshiaki Nakano, @Kumiko Torisu, @Takanari Kitazono

    Clinical and Experimental Nephrology   1 - 10   2022.9

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    DOI： 10.1007/s10157-022-02272-3

  • Protective Roles of Xenotropic and Polytropic Retrovirus Receptor 1 (XPR1) in Uremic Vascular Calcification. International journal

    Hokuto Arase, Shunsuke Yamada, Kumiko Torisu, Masanori Tokumoto, Masatomo Taniguchi, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    Calcified tissue international   110 ( 6 )   685 - 697   2022.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00223-022-00947-3

  • Protective Roles of Xenotropic and Polytropic Retrovirus Receptor 1 (XPR1) in Uremic Vascular Calcification Reviewed International journal

    #Hokuto Arase, @Shunsuke Yamada, @Kumiko Torisu, @Masanori Tokumoto, @Masatomo Taniguchi, Kazuhiko Tsuruya, @Toshiaki Nakano, @Takanari Kitazono

    Calcified Tissue International   110 ( 6 )   685 - 697   2022.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00223-022-00947-3

  • A case of peritoneal dialysis-related peritonitis caused by dialysate leakage with successful treatment by intravenous and intraperitoneal antibiotic therapy. Reviewed

    Kenji Ueki, Akihiro Tsuchimoto, Kumiko Torisu, Kiichiro Fujisaki, Sayaka Tachibana, Keigo Tomita, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    CEN case reports   11 ( 2 )   161 - 165   2022.5   （ ISSN:2192-4449 ）

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    Dialysate leakage is one of the causes of peritoneal dialysis (PD)-related peritonitis. The rate of catheter removal in PD-related peritonitis caused by dialysate leakage (PDPDL) is high, and the correct treatment is unclear. We experienced a case of PDPDL that was treated with intravenous and intraperitoneal antibiotic therapy. A 44-year-old Japanese man had high glucose discharge from the exit site after 14 days of initiating PD, and he had a fever and cloudy effluent with a high white cell count. We diagnosed him with PDPDL and began to administer vancomycin and ceftazidime intraperitoneally. However, the peritonitis could not be ameliorated. A culture examination showed Staphylococcus aureus from the effluent of peritoneal cavity and exit site cultures. We began intraperitoneal cefazolin administration according to a drug susceptibility test, but the effluent cell count remained high. As we added intravenous cefazolin administration, his symptoms and cloudy effluent improved, and the effluent cell count normalized. He has not developed any recurrence of dialysate leakage or peritonitis. Our findings suggest that PD-related peritonitis accompanied by other infectious sites, such as PDPDL, should be treated with additional intravenous antibiotic therapy to taking effect on the infectious sites except for peritoneum and to keep plasma concentration of antibiotics sufficient especially in cases with preserved residual kidney function.

    DOI： 10.1007/s13730-021-00644-4

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  • 透析液漏出に起因する腹膜透析関連腹膜炎に対し抗菌薬静脈内・腹腔内投与が奏効した1例(A case of peritoneal dialysis-related peritonitis caused by dialysate leakage with successful treatment by intravenous and intraperitoneal antibiotic therapy)

    Ueki Kenji, Tsuchimoto Akihiro, Torisu Kumiko, Fujisaki Kiichiro, Tachibana Sayaka, Tomita Keigo, Nakano Toshiaki, Tsuruya Kazuhiko, Kitazono Takanari

    CEN Case Reports   11 ( 2 )   161 - 165   2022.5

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：シュプリンガー・ジャパン(株)  

    症例は44歳男性で、腹膜透析開始14日後にダイアライザー出口部で血糖高値を示し、発熱、透析排液混濁、白血球数増加をきたした。透析液漏出に起因する腹膜透析関連腹膜炎と診断し、バンコマイシン(1g/日)およびセフタジジム(1g/日)の腹腔内投与を開始したが、改善は認められなかった。腹腔内および出口部排液の培養検査にて黄色ブドウ球菌を検出し、薬剤感受性試験をもとにセファゾリン(1.5g/日)腹腔内投与を開始したが、排液細胞数は依然として高値を示した。セファゾリン(1g/日)静脈内投与を追加したところ、症状と排液混濁は改善し、排液細胞数は正常化した。腹膜透析開始2年後も透析液漏出または腹膜炎の再発は認めていない。

  • Sex differences in the 10-year survival of patients undergoing maintenance hemodialysis in the Q-Cohort Study. International journal

    Hiroaki Tsujikawa, Shunsuke Yamada, Hiroto Hiyamuta, Masatomo Taniguchi, Kazuhiko Tsuruya, Kumiko Torisu, Toshiaki Nakano, Takanari Kitazono

    Scientific reports   12 ( 1 )   345 - 345   2022.1

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    DOI： 10.1038/s41598-021-03551-x

  • Risk of Rebleeding in Patients with Small Bowel Vascular Lesions.

    Akira Harada, Takehiro Torisu, Shin Fujioka, Yuichiro Yoshida, Yasuharu Okamoto, Yuta Fuyuno, Atsushi Hirano, Junji Umeno, Kumiko Torisu, Tomohiko Moriyama, Motohiro Esaki, Takanari Kitazono

    Internal medicine (Tokyo, Japan)   60 ( 23 )   3663 - 3669   2021.12

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    DOI： 10.2169/internalmedicine.6341-20

  • Non-invasive fibrosis assessments of non-alcoholic fatty liver disease associated with low estimated glomerular filtration rate among CKD patients: the Fukuoka Kidney disease Registry Study Reviewed International journal

    #Masatoshi Hara, @Shigeru Tanaka, @Kumiko Torisu, @Yuta Matsukuma, @Akihiro Tsuchimoto, @Masanori Tokumoto, Hiroaki Ooboshi, @Toshiaki Nakano, Kazuhiko Tsuruya, @Takanari Kitazono

    Clinical and Experimental Nephrology   25 ( 8 )   822 - 834   2021.8

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    DOI： 10.1007/s10157-020-02018-z

  • Non-invasive fibrosis assessments of non-alcoholic fatty liver disease associated with low estimated glomerular filtration rate among CKD patients: the Fukuoka Kidney disease Registry Study.

    Masatoshi Hara, Shigeru Tanaka, Kumiko Torisu, Yuta Matsukuma, Akihiro Tsuchimoto, Masanori Tokumoto, Hiroaki Ooboshi, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Clinical and experimental nephrology   25 ( 8 )   822 - 834   2021.8

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    DOI： 10.1007/s10157-020-02018-z

  • Risk of rebleeding in patients with small bowel vascular lesions Reviewed International journal

    @Akira Harada, @Takehiro Torisu, @Shin Fujioka, @Yuichiro Yoshida, @Yasuharu Okamoto, @Yuta Fuyuno, @Atsushi Hirano, @Junji Umeno, @Kumiko Torisu, @Tomohiko Moriyama, Motohiro Esaki, @Takanari Kitazono

    Internal Medicine   60 ( 23 )   3663 - 3669   2021.4

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    DOI： 10.2169/internalmedicine.6341-20

  • Stronger Effect of Azilsartan on Reduction of Proteinuria Compared to Candesartan in Patients with CKD: A Randomized Crossover Trial Reviewed International journal

    @Takaichi Suehiro, Kazuhiko Tsuruya, Hisako Yoshida, @Hiroaki Tsujikawa, @Shunsuke Yamada, @Shigeru Tanaka, @Akihiro Tsuchimoto, Masahiro Eriguchi, @Kiichiro Fujisaki, @Kumiko Torisu, @Toshiaki Nakano, @Takanari Kitazono

    Kidney and Blood Pressure Research   46   173 - 184   2021.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000512365

  • Sex Differences in the Survival of Patients Undergoing Maintenance Hemodialysis: A 10-year Outcome of the Q-Cohort Study Reviewed International journal

    @Hiroaki Tsujikawa, @Shunsuke Yamada, Hiroto Hiyamuta, @Masatomo Taniguchi, Kazuhiko Tsuruya, @Kumiko Torisu, @Toshiaki Nakano, @Takanari Kitazono

    Scientific reports   12 ( 1 )   1 - 9   2021.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-021-03551-x

  • B cell receptor signaling related to resistance to Helicobacter pylori eradication therapy in gastric diffuse large B cell lymphoma. International journal

    Takehiro Torisu, Shinichi Kawano, Kohta Miyawaki, Hidetaka Yamamoto, Yutaro Ihara, Yuichi Matsuno, Kumiko Torisu, Takeshi Sugio, Kensuke Sasaki, Takashi Shimakawa, Koji Kato, Koichi Akashi, Shotaro Nakamura, Takanari Kitazono

    Hematological oncology   39 ( 1 )   145 - 147   2021.2

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    DOI： 10.1002/hon.2816

  • B cell receptor signaling related to resistance to Helicobacter pylori eradication therapy in gastric diffuse large B cell lymphoma Reviewed International journal

    @Takehiro Torisu, @Shinichi Kawano, @Kohta Miyawaki, @Hidetaka Yamamoto, @Yutaro Ihara, @Yuichi Matsuno, @Kumiko Torisu, Takeshi Sugio, Kensuke Sasaki, Takashi Shimakawa, @Koji Kato, @Koichi Akashi, @Shotaro Nakamura, @Takanari Kitazono

    Hematological oncology   39 ( 1 )   145 - 147   2021.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/hon.2816

  • The Association between Dialysis Dose and Risk of Cancer Death in Patients Undergoing Hemodialysis: The Q-Cohort Study.

    Masatoshi Hara, Shigeru Tanaka, Masatomo Taniguchi, Kiichiro Fujisaki, Kumiko Torisu, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Internal medicine (Tokyo, Japan)   59 ( 9 )   1141 - 1148   2020.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2169/internalmedicine.4027-19

  • The glucose degradation product methylglyoxal induces immature angiogenesis in patients undergoing peritoneal dialysis. International journal

    Toshiaki Nakano, Torisu Kumiko, Tohru Mizumasa, Yusuke Kuroki, Kazuhiko Tsuruya, Takanari Kitazono

    Biochemical and biophysical research communications   525 ( 3 )   767 - 772   2020.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2020.02.048

  • The glucose degradation product methylglyoxal induces immature angiogenesis in patients undergoing peritoneal dialysis Reviewed International journal

    @T Nakano, @T Kumiko, T Mizumasa, Y Kuroki, K Tsuruya, @T Kitazono

    Biochemical and Biophysical Research Communications   525 ( 3 )   767 - 772   2020.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2020.02.048

  • Association of Lower Serum Bilirubin With Loss of Residual Kidney Function in Peritoneal Dialysis Patients. International journal

    Hiroaki Tsujikawa, Shigeru Tanaka, Masatoshi Hara, Yasuhiro Kawai, Yuta Matsukuma, Kumiko Torisu, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy   24 ( 2 )   202 - 207   2020.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/1744-9987.12865

  • Association of Lower Serum Bilirubin With Loss of Residual Kidney Function in Peritoneal Dialysis Patients Reviewed

    Hiroaki Tsujikawa, Shigeru Tanaka, Masatoshi Hara, Yasuhiro Kawai, Yuta Matsukuma, Kumiko Torisu, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Therapeutic Apheresis and Dialysis   24 ( 2 )   202 - 207   2020.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/1744-9987.12865

  • Hypocomplementemic urticarial vasculitis syndrome with gastrointestinal vasculitis and crescentic membranoproliferative glomerulonephritis without immune complex deposits.

    Kenji Ueki, Akihiro Tsuchimoto, Yuta Matsukuma, Kumiko Torisu, Kiichiro Fujisaki, Takehiro Torisu, Yuichi Yamada, Yoshinao Oda, Kosuke Masutani, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    CEN case reports   9 ( 1 )   30 - 35   2020.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s13730-019-00421-4

  • Adrenal crisis presented as acute onset of hypercalcemia and hyponatremia triggered by acute pyelonephritis in a patient with partial hypopituitarism and pre-dialysis chronic kidney disease.

    Shunsuke Yamada, Hokuto Arase, Toshifumi Morishita, Akihiro Tsuchimoto, Kumiko Torisu, Takehiro Torisu, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    CEN case reports   8 ( 2 )   83 - 88   2019.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s13730-018-0371-9

  • Development of a risk prediction model for infection-related mortality in patients undergoing peritoneal dialysis Reviewed

    Hiroaki Tsujikawa, Shigeru Tanaka, Yuta Matsukuma, Hidetoshi Kanai, Kumiko Torisu, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    PloS one   14 ( 3 )   2019.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0213922

  • Rapidly Progressive Glomerulonephritis with Delayed Appearance of Anti-Glomerular Basement Membrane Antibody Successfully Treated with Multiple Courses of Steroid Pulse Therapy Reviewed

    Satoshi Toyota, Masahiro Eriguchi, Shoko Hasegawa, Kenji Ueki, Yuta Matsukuma, Akihiro Tsuchimoto, Kiichiro Fujisaki, Kumiko Torisu, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono

    Case Reports in Nephrology and Dialysis   9 ( 1 )   25 - 32   2019.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000499401

  • Prognostic value of pre-dialysis blood pressure and risk threshold on clinical outcomes in hemodialysis patients: The Q-Cohort Study. International journal

    Masatoshi Hara, Shigeru Tanaka, Masatomo Taniguchi, Kiichiro Fujisaki, Kumiko Torisu, Kosuke Masutani, Hideki Hirakata, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Medicine   97 ( 51 )   e13485   2018.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/MD.0000000000013485

  • Prognostic value of pre-dialysis blood pressure and risk threshold on clinical outcomes in hemodialysis patients The Q-Cohort Study Reviewed

    Masatoshi Hara, Shigeru Tanaka, Masatomo Taniguchi, Kiichiro Fujisaki, Kumiko Torisu, Kosuke Masutani, Hideki Hirakata, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

    Medicine (United States)   97 ( 51 )   2018.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/MD.0000000000013485

  • Hemoglobin concentration and the risk of hemorrhagic and ischemic stroke in patients undergoing hemodialysis: the Q-cohort study. International journal

    Ryusuke Yotsueda, Shigeru Tanaka, Masatomo Taniguchi, Kiichiro Fujisaki, Kumiko Torisu, Kosuke Masutani, Hideki Hirakata, Takanari Kitazono, Kazuhiko Tsuruya

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   33 ( 5 )   856 - 864   2018.5

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    DOI： 10.1093/ndt/gfx305

  • Association between serum albumin level and incidence of end-stage renal disease in patients with Immunoglobulin A nephropathy A possible role of albumin as an antioxidant agent Reviewed

    Yasuhiro Kawai, Kosuke Masutani, Kumiko Torisu, Ritsuko Katafuchi, Shigeru Tanaka, Akihiro Tsuchimoto, Koji Mitsuiki, Kazuhiko Tsuruya, Takanari Kitazono

    PloS one   13 ( 5 )   2018.5

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    DOI： 10.1371/journal.pone.0196655

  • Hemoglobin concentration and the risk of hemorrhagic and ischemic stroke in patients undergoing hemodialysis The Q-cohort study Reviewed

    Ryusuke Yotsueda, Shigeru Tanaka, Masatomo Taniguchi, Kiichiro Fujisaki, Kumiko Torisu, Kosuke Masutani, Hideki Hirakata, Takanari Kitazono, Kazuhiko Tsuruya

    Nephrology Dialysis Transplantation   33 ( 5 )   856 - 864   2018.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/ndt/gfx305

  • Vascular endothelial growth factor-C ameliorates renal interstitial fibrosis through lymphangiogenesis in mouse unilateral ureteral obstruction. International journal

    Shoko Hasegawa, Toshiaki Nakano, Kumiko Torisu, Akihiro Tsuchimoto, Masahiro Eriguchi, Naoki Haruyama, Kosuke Masutani, Kazuhiko Tsuruya, Takanari Kitazono

    Laboratory investigation; a journal of technical methods and pathology   97 ( 12 )   1439 - 1452   2017.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/labinvest.2017.77

  • Vascular endothelial growth factor-C ameliorates renal interstitial fibrosis through lymphangiogenesis in mouse unilateral ureteral obstruction Reviewed

    Shoko Hasegawa, Toshiaki Nakano, Kumiko Torisu, Akihiro Tsuchimoto, Masahiro Eriguchi, Naoki Haruyama, Kosuke Masutani, Kazuhiko Tsuruya, Takanari Kitazono

    Laboratory Investigation   97 ( 12 )   1439 - 1452   2017.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/labinvest.2017.77

  • Autophagy promotes degradation of internalized collagen and regulates distribution of focal adhesions to suppress cell adhesion. International journal

    Shinichi Kawano, Takehiro Torisu, Motohiro Esaki, Kumiko Torisu, Yuichi Matsuno, Takanari Kitazono

    Biology open   6 ( 11 )   1644 - 1653   2017.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1242/bio.027458

  • Autophagy promotes degradation of internalized collagen and regulates distribution of focal adhesions to suppress cell adhesion Reviewed

    Shinichi Kawano, Takehiro Torisu, Motohiro Esaki, Kumiko Torisu, Yuichi Matsuno, Takanari Kitazono

    Biology Open   6 ( 11 )   1644 - 1653   2017.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1242/bio.027458

  • Cardiothoracic Ratio and All-Cause Mortality and Cardiovascular Disease Events in Hemodialysis Patients: The Q-Cohort Study. International journal

    Ryusuke Yotsueda, Masatomo Taniguchi, Shigeru Tanaka, Masahiro Eriguchi, Kiichiro Fujisaki, Kumiko Torisu, Kosuke Masutani, Hideki Hirakata, Takanari Kitazono, Kazuhiko Tsuruya

    American journal of kidney diseases : the official journal of the National Kidney Foundation   70 ( 1 )   84 - 92   2017.7

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    DOI： 10.1053/j.ajkd.2016.11.026

  • Cardiothoracic Ratio and All-Cause Mortality and Cardiovascular Disease Events in Hemodialysis Patients The Q-Cohort Study Reviewed

    Ryusuke Yotsueda, Masatomo Taniguchi, Shigeru Tanaka, Masahiro Eriguchi, Kiichiro Fujisaki, Kumiko Torisu, Kosuke Masutani, Hideki Hirakata, Takanari Kitazono, Kazuhiko Tsuruya

    American Journal of Kidney Diseases   70 ( 1 )   84 - 92   2017.7

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    DOI： 10.1053/j.ajkd.2016.11.026

  • A J-shaped association between serum uric acid levels and poor renal survival in female patients with IgA nephropathy. International journal

    Yuta Matsukuma, Kosuke Masutani, Shigeru Tanaka, Akihiro Tsuchimoto, Kiichiro Fujisaki, Kumiko Torisu, Ritsuko Katafuchi, Hideki Hirakata, Kazuhiko Tsuruya, Takanari Kitazono

    Hypertension research : official journal of the Japanese Society of Hypertension   40 ( 3 )   291 - 297   2017.3

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    DOI： 10.1038/hr.2016.134

  • A J-shaped association between serum uric acid levels and poor renal survival in female patients with IgA nephropathy Reviewed

    Yuta Matsukuma, Kosuke Masutani, Shigeru Tanaka, Akihiro Tsuchimoto, Kiichiro Fujisaki, Kumiko Torisu, Ritsuko Katafuchi, Hideki Hirakata, Kazuhiko Tsuruya, Takanari Kitazono

    Hypertension Research   40 ( 3 )   291 - 297   2017.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/hr.2016.134

  • Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity Reviewed

    Journal of Clinical Investigation   126 ( 11 )   4219 - 4236   2016.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1172/JCI85647

  • Extended Swan-Neck Catheter With Upper Abdominal Exit-Site Reduces Peritoneal Dialysis-Related Infections. International journal

    Masahiro Eriguchi, Kazuhiko Tsuruya, Hisako Yoshida, Naoki Haruyama, Shigeru Tanaka, Akihiro Tsuchimoto, Kiichiro Fujisaki, Kumiko Torisu, Kosuke Masutani, Takanari Kitazono

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy   20 ( 2 )   158 - 64   2016.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/1744-9987.12358

  • Extended Swan-Neck Catheter With Upper Abdominal Exit-Site Reduces Peritoneal Dialysis-Related Infections Reviewed

    Masahiro Eriguchi, Kazuhiko Tsuruya, Hisako Yoshida, Naoki Haruyama, Shigeru Tanaka, Akihiro Tsuchimoto, Kiichiro Fujisaki, Kumiko Torisu, Kosuke Masutani, Takanari Kitazono

    Therapeutic Apheresis and Dialysis   20 ( 2 )   158 - 164   2016.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/1744-9987.12358

  • Assessment of urinary angiotensinogen as a marker of podocyte injury in proteinuric nephropathies. International journal

    Masahiro Eriguchi, Ryusuke Yotsueda, Kumiko Torisu, Yasuhiro Kawai, Shoko Hasegawa, Shigeru Tanaka, Hideko Noguchi, Kosuke Masutani, Takanari Kitazono, Kazuhiko Tsuruya

    American journal of physiology. Renal physiology   310 ( 4 )   F322-33   2016.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1152/ajprenal.00260.2015

  • Intact endothelial autophagy is required to maintain vascular lipid homeostasis Reviewed

    Kumiko Torisu, Krishna K. Singh, Takehiro Torisu, Fina Lovren, Jie Liu, Yi Pan, Adrian Quan, Azza Ramadan, Mohammed Al-Omran, Natalie Pankova, Shelley R. Boyd, Subodh Verma, Toren Finkel

    Aging cell   15 ( 1 )   187 - 191   2016.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/acel.12423

  • Assessment of urinary angiotensinogen as a marker of podocyte injury in proteinuric nephropathies Reviewed

    Masahiro Eriguchi, Ryusuke Yotsueda, Kumiko Torisu, Yasuhiro Kawai, Shoko Hasegawa, Shigeru Tanaka, Hideko Noguchi, Kosuke Masutani, Takanari Kitazono, Kazuhiko Tsuruya

    American Journal of Physiology - Renal Physiology   310 ( 4 )   F322 - F333   2016.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1152/ajprenal.00260.2015

  • Spironolactone ameliorates arterial medial calcification in uremic rats: the role of mineralocorticoid receptor signaling in vascular calcification. International journal

    Narihito Tatsumoto, Shunsuke Yamada, Masanori Tokumoto, Masahiro Eriguchi, Hideko Noguchi, Kumiko Torisu, Kazuhiko Tsuruya, Takanari Kitazono

    American journal of physiology. Renal physiology   309 ( 11 )   F967-79   2015.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1152/ajprenal.00669.2014

  • Membranoproliferative glomerulonephritis with predominant IgG2 and IgG3 deposition in a patient with IgG4-related disease. International journal

    Kenji Ueki, Yuta Matsukuma, Kosuke Masutani, Akihiro Tsuchimoto, Kiichiro Fujisaki, Kumiko Torisu, Shigeru Tanaka, Tamotsu Kiyoshima, Satoshi Hisano, Takanari Kitazono, Kazuhiko Tsuruya

    BMC nephrology   16   173 - 173   2015.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s12882-015-0164-8

  • Membranoproliferative glomerulonephritis with predominant IgG2 and IgG3 deposition in a patient with IgG4-related disease Reviewed

    Kenji Ueki, Yuta Matsukuma, Kosuke Masutani, Akihiro Tsuchimoto, Kiichiro Fujisaki, Kumiko Torisu, Shigeru Tanaka, Tamotsu Kiyoshima, Satoshi Hisano, Takanari Kitazono, Kazuhiko Tsuruya

    BMC Nephrology   16 ( 1 )   2015.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s12882-015-0164-8

  • Erratum Characterization of the structure and expression of mouse Itpa gene and its related sequences in the mouse genome (DNA Research (2015) 12:1 (39-51) DOI: 10.1093/dnares/12.1.39) Reviewed

    M. Behmanesh, K. Sakumi, D. Tsuchimoto, K. Torisu, Y. Ohnishi-Honda, D. E. Rancourt, Y. Nakabeppu

    DNA Research   22 ( 2 )   2015.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/dnares/dsv006

  • Renal denervation has blood pressure-independent protective effects on kidney and heart in a rat model of chronic kidney disease. International journal

    Masahiro Eriguchi, Kazuhiko Tsuruya, Naoki Haruyama, Shunsuke Yamada, Shigeru Tanaka, Takaichi Suehiro, Hideko Noguchi, Kosuke Masutani, Kumiko Torisu, Takanari Kitazono

    Kidney international   87 ( 1 )   116 - 27   2015.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/ki.2014.220

  • Renal denervation has blood pressure-independent protective effects on kidney and heart in a rat model of chronic kidney disease Reviewed

    Masahiro Eriguchi, Kazuhiko Tsuruya, Naoki Haruyama, Shunsuke Yamada, Shigeru Tanaka, Takaichi Suehiro, Hideko Noguchi, Kosuke Masutani, Kumiko Torisu, Takanari Kitazono

    Kidney International   87 ( 1 )   116 - 127   2015.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/ki.2014.220

  • Spironolactone ameliorates arterial medial calcification in uremic rats The role of mineralocorticoid receptor signaling in vascular calcification Reviewed

    Narihito Tatsumoto, Shunsuke Yamada, Masanori Tokumoto, Masahiro Eriguchi, Hideko Noguchi, Kumiko Torisu, Kazuhiko Tsuruya, Takanari Kitazono

    American Journal of Physiology - Renal Physiology   309 ( 11 )   F967 - F979   2015.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1152/ajprenal.00669.2014

  • Improvement in spatial memory dysfunction by telmisartan through reduction of brain angiotensin II and oxidative stress in experimental uremic mice. International journal

    Naoki Haruyama, Kiichiro Fujisaki, Mayumi Yamato, Masahiro Eriguchi, Hideko Noguchi, Kumiko Torisu, Kazuhiko Tsuruya, Takanari Kitazono

    Life sciences   113 ( 1-2 )   55 - 9   2014.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.lfs.2014.07.032

  • Improvement in spatial memory dysfunction by telmisartan through reduction of brain angiotensin II and oxidative stress in experimental uremic mice Reviewed

    Naoki Haruyama, Kiichiro Fujisaki, Mayumi Yamato, Masahiro Eriguchi, Hideko Noguchi, Kumiko Torisu, Kazuhiko Tsuruya, Takanari Kitazono

    Life Sciences   113 ( 1-2 )   55 - 59   2014.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.lfs.2014.07.032

  • Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis. International journal

    Takehiro Torisu, Mako Nakaya, Satoko Watanabe, Masayuki Hashimoto, Hideyuki Yoshida, Takatoshi Chinen, Ryoko Yoshida, Fuyuki Okamoto, Toshikatsu Hanada, Kumiko Torisu, Giichi Takaesu, Takashi Kobayashi, Hideo Yasukawa, Akihiko Yoshimura

    Hepatology (Baltimore, Md.)   47 ( 5 )   1644 - 54   2008.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/hep.22214

  • Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis Reviewed

    Takehiro Torisu, Mako Nakaya, Satoko Watanabe, Masayuki Hashimoto, Hideyuki Yoshida, Takatoshi Chinen, Ryoko Yoshida, Fuyuki Okamoto, Toshikatsu Hanada, Kumiko Torisu, Giichi Takaesu, Takashi Kobayashi, Hideo Yasukawa, Akihiko Yoshimura

    Hepatology   47 ( 5 )   1644 - 1654   2008.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/hep.22214

  • Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein. International journal

    Kumiko Torisu, Daisuke Tsuchimoto, Yoshinori Ohnishi, Yusaku Nakabeppu

    Journal of biochemistry   138 ( 6 )   763 - 72   2005.12

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Characterization of the structure and expression of mouse Itpa gene and its related sequences in the mouse genome. International journal

    Mehrdad Behmanesh, Kunihiko Sakumi, Daisuke Tsuchimoto, Kumiko Torisu, Yoko Ohnishi-Honda, Derrick E Rancourt, Yusaku Nakabeppu

    DNA research : an international journal for rapid publication of reports on genes and genomes   12 ( 1 )   39 - 51   2005.2

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Characterization of the structure and expression of mouse Itpa gene and its related sequences in the mouse genome Reviewed

    Mehrdad Behmanesh, Kunihiko Sakumi, Daisuke Tsuchimoto, Kumiko Torisu, Yoko Ohnishi-Honda, Derrick E. Rancourt, Yusaku Nakabeppu

    DNA Research   12 ( 1 )   39 - 51   2005.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/dnares/12.1.39

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Presentations

  • アルギニン代謝を通して腎保護を考える Invited

    鳥巣久美子

    第53回日本腎臓学会西部学術集会  2023.10 

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    Event date： 2023.10

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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  • アルギニン代謝とAKI Invited

    鳥巣久美子

    第65回日本腎臓学会学術集会  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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  • Endothelial Autophagy Is Essential for Vascular Lipid Homeostasis International conference

    Kumiko Torisu, Torisu Takehiro, Finkel Toren

    American Society of Nephrology, Kidney Week 2015  2015.11 

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    Event date： 2015.11

    Language：English  

    Country：United States  

  • アルギナーゼ2はシスプラチン誘発急性腎障害においてマクロファージの炎症応答を促進する

    内田 裕士, 鳥巣 久美子, 相原 成志, 大星 博明, 中野 敏昭, 北園 孝成

    日本腎臓学会誌  2023.5  (一社)日本腎臓学会

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    Language：Japanese   Presentation type：Oral presentation (general)  

  • アルギナーゼ2はスペルミジン産生を介して腎間質線維化を制御する

    相原 成志, 鳥巣 久美子, 中野 敏昭, 北園 孝成

    日本腎臓学会誌  2022.5  (一社)日本腎臓学会

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    Language：Japanese   Presentation type：Oral presentation (general)  

  • The Superiority of Urinary Angiotensinogen to Proteinuria as a Marker of Podocyte Injury International conference

    Masahiro Eriguchi, Kumiko Torisu, Kazuhiko Tsuruya

    American Society of Nephrology, Kidney Week 2014  2014.11 

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    Event date： 2014.11

    Language：English  

    Country：United States  

  • Inhibitory Effect of Vascular Endothelial Growth Factor-C on Renal Interstitial Infl ammation and Fibrosis through Lymphangiogenesis in Mouse Unilateral Ureteral Obstruction International conference

    Shoko Hasegawa, Toshiaki Nakano, Kumiko Torisu, Kazuhiko Tsuruya

    American Society of Nephrology, Kidney Week 2014  2014.11 

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    Event date： 2014.11

    Language：English  

    Country：United States  

  • Role of Calciprotein Particle-Induced Autophagy in Calcifi cation of Human Smooth Muscle Cells International conference

    American Society of Nephrology, Kidney Week 2014  2014.11 

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    Event date： 2014.11

    Language：English  

    Country：United States  

  • VEGF-Cによる腎線維化抑制効果

    長谷川　祥子, 中野 敏昭, 鳥巣久美子, 土本 晃裕, 春山　直樹, 江里口　雅裕, 鶴屋 和彦, 北園 孝成

    第57回日本腎臓学会学術総会  2014.7 

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    Event date： 2014.7

    Language：Japanese  

    Venue：パシフィコ横浜   Country：Japan  

    【目的】腎線維化の進行に伴いリンパ管が増生することが報告されている．今回我々は，片側尿管結紮(UUO)モデルを用いて，リンパ管新生に関与する血管内皮増殖因子 Vascular endothelial growth factor-C (VEGF-C)の腎線維化への関与について検討した．【方法】7週齢の雄性C57BL6マウスにUUO術を施行し，同時にVEGF-Cを持続投与した群(U+VC群，n=5)と無投与群(U群，n=5)において，リンパ管新生(LYVE-1染色)，間質線維化(Sirius red染色)および線維化関連遺伝子発現(collagen I mRNA,αSMA蛋白)，マクロファージ浸潤(F4/80染色)を比較検討した．【結果】U群では経時的にリンパ管増生，VEGF-R3 mRNA発現亢進，線維化進行、Collagen I mRNA及びαSMA蛋白の発現亢進，マクロファージ浸潤の増加が認められた．一方，U+VC群では，U群に比べ，リンパ管増生の亢進傾向，VEGF-R3蛋白の発現亢進(2.18倍 ,p＜0.05)に伴い，Collagen I mRNA発現の抑制(0.45倍 ,p＜0.05)，αSMA蛋白発現の抑制傾向とともに，間質線維化は軽減(0.53倍, p＜0.01)した．【結論】VEGF-C投与によりリンパ管新生が促進され，腎間質の炎症と線維化が抑制された．

  • 腎障害とエネルギー・代謝研究の新たな展開　アルギニン代謝を通して腎保護を考える

    鳥巣 久美子, 相原 成志, 内田 裕士, 中野 敏昭

    日本腎臓学会誌  2023.9  (一社)日本腎臓学会

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    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

  • Arginine metabolism is activated in kidney fibrosis to produce spermidine, which acts in antifibrosis through induction of Nrf2

    Kumiko Torisu

    2022.12 

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    Language：English   Presentation type：Symposium, workshop panel (public)  

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  • 虚血再灌流モデルマウスに対するluseogliflozinの効果の検討

    平島 佑太郎, 中野 敏昭, 鳥巣 久美子, 北園 孝成

    日本腎臓学会誌  2024.6  (一社)日本腎臓学会

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    Language：Japanese   Presentation type：Oral presentation (general)  

  • 腹膜透析液中グルコース分解物は血管内皮細胞及び血管平滑筋細胞における血管新生因子の調節不全を介して未熟な血管新生に寄与する

    相原 成志, 中野 敏昭, 鳥巣 久美子, 北園 孝成

    日本透析医学会雑誌  2022.5  (一社)日本透析医学会

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    Language：Japanese   Presentation type：Oral presentation (general)  

  • Arginine metabolism is activated in kidney fibrosis to produce spermidine, which acts in antifibrosis through induction of Nrf2

    Kumiko Torisu

    2022.11 

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    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

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  • 線維化,再生　アルギナーゼ2を介する抗線維化作用 Invited

    鳥巣 久美子, 相原 成志, 中野 敏昭, 北園 孝成

    日本腎臓学会誌  2022.10  (一社)日本腎臓学会

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    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

  • 新規解析手法とTargetでAKIに挑む　アルギニン代謝とAKI Invited

    鳥巣 久美子, 内田 裕士, 相原 成志, 原 雅俊, 中野 敏昭

    日本腎臓学会誌  2022.5  (一社)日本腎臓学会

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    Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

  • 急性腎障害におけるアクロレイン産生は尿細管細胞死を誘導する

    相原 成志, 鳥巣 久美子, 中野 敏昭, 北園 孝成

    日本腎臓学会誌  2023.5  (一社)日本腎臓学会

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    Language：Japanese   Presentation type：Oral presentation (general)  

  • 低浸透圧環境は血管石灰化を増悪させる

    松枝 修明, 山田 俊輔, 鳥巣 久美子, 北園 孝成, 中野 敏昭

    日本腎臓学会誌  2023.5  (一社)日本腎臓学会

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    Language：Japanese   Presentation type：Oral presentation (general)  

  • 中性液使用における被嚢性腹膜硬化症患者の臨床的特徴

    辻川 浩明, 中野 敏昭, 原田 健司, 黒木 裕介, 鳥巣 久美子, 徳本 正憲, 鶴屋 和彦, 金井 英俊, 北園 孝成

    日本透析医学会雑誌  2022.5  (一社)日本透析医学会

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    Language：Japanese   Presentation type：Oral presentation (general)  

  • インドキシル硫酸はFGFR4・FGF23経路を介して心筋細胞の肥大を促進する

    岸本 啓志, 中野 敏昭, 鳥巣 久美子, 山田 俊輔, 徳本 正憲, 谷口 正智, 北園 孝成

    日本内分泌学会雑誌  2022.3  (一社)日本内分泌学会

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    Language：Japanese   Presentation type：Oral presentation (general)  

  • 「人に頼る力」で働き方の多様化を支える

    鳥巣久美子

    第12回腎臓リハビリテーション学会 

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MISC

Professional Memberships

  • 分子生物学会

    2022.1 - Present

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  • Japanese Soceity of Nephrology

    2000.4 - Present

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  • The Japanese Society of Dialysis Therapy

    2000.4 - Present

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  • The Japanese Society of Internal Medicine

    1998.5 - Present

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  • Japanese　Society of Nephlorogy

  • Japanese Society for Dialysis therapy

  • The Japanese Society of Internal Medicine

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Committee Memberships

  • Japanese Society of Nephrology   Member of the Committee for the Second Five-Year Plan  

    2021.11 - Present   

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    Committee type：Academic society

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  • Japanese Society of Nephrology   JSN NEXT Frontiers 2028 comittee  

    2020.4 - Present   

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    Committee type：Academic society

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  • Japanese Society of Womens Nephrologists   Academic Research Committee  

    2019.4 - Present   

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    Committee type：Academic society

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  • Japanese Society of Nephrology   Diversity Promotion Committee  

    2018.4 - Present   

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    Committee type：Academic society

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  • Japanese Society of Nephrology   Basic Research Subcommittee  

    2016.4 - Present   

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    Committee type：Academic society

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Academic Activities

  • ワークショップの座長

    第６０回日本腎臓学会学術総会  （ 仙台市 ） 2017.5

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    Type：Competition, symposium, etc. 

  • local comittee International contribution

    （ Japan ） 2017.1 - 2018.3

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    Type：Competition, symposium, etc. 

  • 委員

    日本腎臓学会　基礎研究小委員会  2016.4 - 2018.3

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    Type：Competition, symposium, etc. 

  • シンポジウムでの基調講演演者

    第９回九州山口薬学会ファーマシューティカルケアシンポジウム  （ 九州大学医学部百年講堂 ） 2016.2

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    Type：Competition, symposium, etc. 

    Number of participants：100

  • 講演者

    第44回日本腎臓学会西部学術大会　男女共同参画企画  （ 神戸 ） 2014.10

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    Type：Competition, symposium, etc. 

    Number of participants：100

Research Projects

  • 抗加齢因子スペルミジンが腎臓、そして全身を守る

    Grant number：23K07675  2023 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type：Scientific research funding

  • 腹膜透析による腹膜線維化と石灰化の病態解明～リンの関与とマグネシウムの競合作用

    Grant number：22K08355  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    山田 俊輔, 中野 敏昭, 鳥巣 久美子

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

    本研究は腹膜透析患者の重大な合併症である腹膜線維化および被嚢性腹膜硬化症(EPS)の予防と進展を抑制する有効な治療としてマグネシウム(Mg)に注目した基礎実験である。Mgは腹膜透析患者の体内で増加するcalciprotein particle (CPP)の形成を抑制し、CPPによる腹膜の炎症や線維化を阻止できることを明らかにする基礎研究である。本研究の遂行により、腹膜線維化やEPSの予防や進展抑制のみならず、種々の臓器における炎症や線維化過程をも抑制できる治療法として、Mg補充療法を定期することを最終目標に設定している。

    CiNii Research

  • 慢性腎臓病における心筋肥大の機序解明

    Grant number：21K08232  2021 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    中野 敏昭, 山田 俊輔, 鳥巣 久美子

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

    慢性腎臓病患者において心不全は主要な死因の一つであり、その原因として心筋肥大の合併が多いことが報告されている。近年、リン利尿ホルモンであるFGF23と心筋肥大との関連が報告されている。尿毒素であるインドキシル硫酸がFGF23の発現に影響を与えるか更に慢性腎臓病の心筋肥大に影響しているかを検討し、腎不全患者の予後を改善するための新規機序について検討する。

    CiNii Research

  • 腸腎連関・慢性腎臓病に影響を及ぼす腸内細菌叢と細菌由来代謝産物の探索

    Grant number：21K06783  2021 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    鳥巣 剛弘, 鳥巣 久美子, 梅野 淳嗣

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

    慢性腎臓病において、腸内細菌叢から産生される尿毒素が病態に大きくかかわるが、過去の腸内細菌叢と全身疾患の報告は便中細菌を解析しており、実際の小腸粘膜内の細菌とその代謝産物を調べた報告はほとんどない。我々の予備実験では便と小腸の細菌叢は大きく異なり、特にアミノ酸代謝に関わる細菌叢が異なるという知見を得た。本研究では小腸検体を解析し、腸内細菌叢と小腸内の腸内細菌による代謝産物を同定する。慢性腎臓病患者のステージや病期進行に関与する腸内細菌とその代謝産物を絞り込み、腸管や全身へ影響を解析する。また慢性腎臓病モデルマウスを用いて腸内細菌や代謝産物の制御による治療の可能性を探る。

    CiNii Research

  • アルギニン代謝とオートファジー～腎臓のミトコンドリア保護機構の解明

    Grant number：20K08610  2020 - 2022

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 骨格筋・血管相関の概念の応用による血管石灰化治療とその分子機構の究明

    Grant number：19K08706  2019 - 2021

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    山田 俊輔, 中野 敏昭, 鳥巣 久美子

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

    近年、骨格筋と骨と血管の間には密接な関係があり、これらの臓器の正常な機能が、各臓器から分泌されるたんぱく質によって強く影響を受け、臓器機能が正常に維持されていることが明らかになった。本研究の目的は、骨格筋・骨・血管の相互関係を、慢性腎臓病患者が合併する血管石灰化の治療に応用することである。本研究は、培養細胞実験とマウスを用いた動物実験からなる。培養細胞実験では、骨格筋から分泌されるマイオカインを培養血管平滑筋細胞に投与し、リンによる平滑筋細胞の石灰化を抑制できるかを確認する。また、動物実験では、腎不全マウスにマイオカインを投与し、血管石灰化が抑制されるか、筋肉量が増加するかどうかを確認する。

    CiNii Research

  • 慢性腎臓病高齢者を対象とした認知機能障害と動脈硬化に関する縦断的コホート研究

    Grant number：18K08213  2018 - 2020

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type：Scientific research funding

  • 尿細管のアルブミン再吸収におけるオートファジーの役割

    2017.1 - 2019.3

    日本女性腎臓医の会  日本女性腎臓医の会研究奨励賞

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    Authorship：Principal investigator 

    尿細管がアルブミンに暴露されたとき、再吸収や炎症反応、トランスサイト―シスを行うと考えられるが、それらの過程にオートファジーが関与すると仮定して研究を行う。

  • 急性腎障害におけるアルギナーゼ２の役割とその制御機構の解明

    Grant number：17K09701  2017 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 急性腎障害におけるアルギナーゼ２の役割とその制御機構の解明

    Grant number：17K09701  2017 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type：Scientific research funding

  • メサンギウム細胞からのコラーゲン分泌におけるオートファジーの役割

    2016.5

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    Authorship：Principal investigator 

  • オートファジーは血管石灰化を抑制するか？

    Grant number：オートファジーは血管石灰化を抑制するか?  2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • オートファジーは血管石灰化を抑制するか？

    Grant number：26461255  2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type：Scientific research funding

  • 動脈硬化におけるPKCetaの役割

    2013.4 - 2017.3

    Ｊａｐａｎ 

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    Authorship：Principal investigator 

    脳梗塞感受性遺伝子として発見されたPKCetaのSNPに関して、キナーゼ活性の上昇が動脈硬化の促進につながると予想されている。そこでPKCetaノックアウトマウスを用いて動脈硬化を解析し、PKCetaの動脈硬化の進展における役割を明らかにした。PKCetaノックアウトマウスは動脈硬化が軽減し、動脈硬化部位でのNOの産生が低下している所見が得られた。本プロジェクトで得られた結果はGenes to Cell誌にacceptされた。

  • 動脈硬化におけるオートファジーの役割 International coauthorship

    2013.4 - 2015.12

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    Authorship：Principal investigator 

    血管内皮細胞はLDL cholesterolを内皮下に取り込むが、この過程がオートファジーに依存していることがわかった。オートファジーを減弱させた血管内皮細胞はLDL cholesterolの取り込みが亢進していることがわかった。これに一致してオートファジーノックアウトマウスでは動脈硬化が促進していることが明らかになった。

  • 動脈硬化における酸化DNA障害とその防御機構

    Grant number：20790535  2008 - 2009

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type：Scientific research funding

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Educational Activities

  • I have a lecture on kidney disease, urinary examination to medical students or students of health sciences.
    I train medical students in bedside training or clinical clerkship for 10 weeks per year.
    I guide 3rd grade students in reading papers and teach them to do molecular biology experiments.
    I give a guidance to six graduate students on their own projects.

Class subject

  • 尿の診断法実習

    2017.10 - 2018.3   Second semester

  • ベッドサイド実習

    2017.4 - 2018.3   Full year

  • クリニカルクラークシップ実習

    2017.4 - 2017.9   First semester

  • 続発性腎炎・ネフローゼ症候群

    2016.10 - 2017.3   Second semester

  • 尿の診断法実習

    2016.4 - 2017.3   Full year

  • クリニカルクラークシップ実習

    2016.4 - 2017.3   Full year

  • ベッドサイド実習

    2016.4 - 2017.3   Full year

  • 急性腎不全の病態と治療、続発性腎炎、ネフローゼ症候群

    2015.10 - 2016.3   Second semester

  • クリニカルクラークシップ実習

    2015.4 - 2016.3   Full year

  • 尿の診断法実習

    2015.4 - 2016.3   Full year

  • ベッドサイド実習

    2015.4 - 2015.9   First semester

  • 急性腎不全の病態と治療、続発性腎炎、ネフローゼ症候群

    2014.10 - 2015.3   Second semester

  • 尿の診断法実習

    2014.4 - 2015.3   Full year

▼display all

FD Participation

  • 2014.8   Role：Participation   Title：臨床実習専門委員会

    Organizer：[Undergraduate school/graduate school/graduate faculty]

Other educational activity and Special note

  • 2014  Coaching of Students' Association 

Social Activities

  • CKD市民公開講座

    福岡市・一般社団法人福岡市医師会  福岡ファッションビル  2015.3

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    Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Lecture

    CKDの予防と治療についてわかりやすく説明する。

Media Coverage

  • 腎代替療法についての内容の説明 Newspaper, magazine

    朝日新聞広告  2017.6

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    腎代替療法についての内容の説明

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Nephrology

Clinician qualification

  • Certifying physician

    The Japanese Society of Internal Medicine（JSIM）

Year of medical license acquisition

  • 1998

Notable Clinical Activities

  • 外来において腎臓内科再来を週２日担当、また腹膜透析再来の週１日担当している。 腎臓研究室のスタッフとして、週１回の病棟入院患者のカンファレンス、回診に参加している。また腎臓・高血圧・脳血管内科の医師として、週１回の入退院紹介のカンファレンスにも参加している。 また臨床研究にも積極的に参加し、患者の登録を行っている。また、新規副甲状腺機能亢進症治療薬の治験の患者の担当医として、治験にも参加している。