Updated on 2024/09/03

Information

 

写真a

 
OGINO HARUEI
 
Organization
Faculty of Medical Sciences Lecturer
Title
Lecturer
Profile
九州大学病院　肝臓・膵臓・胆道内科にて消化管疾患の研究・診療・教育活動に従事している。 研究： 炎症性腸疾患はクローン病と潰瘍性大腸炎からなる、遺伝性素因・免疫学的素因・環境的素因が関与する難治性の疾患である。欧米で多い疾患とされてきたが、環境因子の影響もあり日本を含めたアジアでも患者数が激増している。免疫学的素因として、クローン病はTh1/Th17細胞、潰瘍性大腸炎はTh2/Th17が関与していると考えられており、炎症性腸疾患の患者様は、このエフェクターT細胞と免疫を制御するとされているT細胞のバランスが破綻していることや、環境因子としての腸内細菌叢の異常が病態に大きく関与している。我々は免疫学的機序や腸内細菌を含めた環境因子を基礎研究・臨床研究から解明し、炎症性腸疾患にて苦しんでいる患者様の助けになりたいと考えている。 診療： 炎症性腸疾患は大部分が軽症・中等症の患者様であるが、５％弱は非常に症状が重篤な重症や劇症症例が含まれている。この様な重篤な患者様や、軽症・中等症の患者様の中でも治療抵抗性・難治性の患者様の治療も積極的に行っている。 さらに、消化管癌に対する内視鏡治療として内視鏡粘膜下層剥離術を用いた侵襲の少ない治療を行っている。消化管癌は早期に発見することで内視鏡的に切除することが可能である。さらに下咽頭領域に対する内視鏡的治療も耳鼻科の先生と協力し積極的に行っている。 教育面では、上記内容を含めて大学院生・病棟医員・医学部生に対する指導・講義を行っている。
External link

Degree

  • PhD

Research Interests・Research Keywords

  • Research theme：Clarification of the pathology and examination of treatment policy in IBD

    Keyword：IBD

    Research period： 2017.4 - 2023.4

Papers

  • Effective hemostasis with a self-assembling peptide hemostatic gel to manage leaky hemorrhage at the ulcer closure site after gastric endoscopic submucosal dissection. International journal

    Ryohei Maruoka, Mitsuru Esaki, Yosuke Minoda, Yoshihiro Otsuka, Kazuhiro Haraguchi, Haruei Ogino, Eikichi Ihara

    Endoscopy   56 ( S 01 )   E323-E324   2024.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1055/a-2291-9050

  • Antral early gastric neoplasm with severe oral scarring successfully treated by endoscopic submucosal dissection using retroflex approach and a novel, thin therapeutic endoscope. International journal

    Ryohei Maruoka, Mitsuru Esaki, Yosuke Minoda, Mei Tadokoro, Kazuhiro Haraguchi, Haruei Ogino, Eikichi Ihara

    Endoscopy   56 ( S 01 )   E703 - E705   2024.12   （ ISSN:0013-726X eISSN:1438-8812 ）

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1055/a-2371-0911

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  • Protective role of M3 muscarinic acetylcholine receptor in indomethacin-induced small intestinal injury. International journal

    Yoko Igarashi-Hisayoshi, Eikichi Ihara, Xiaopeng Bai, Yoshimasa Tanaka, Haruei Ogino, Takatoshi Chinen, Yasushi Taguchi, Yoshihiro Ogawa

    Journal of molecular medicine (Berlin, Germany)   2024.8   （ ISSN:0946-2716 ）

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    Language：English   Publishing type：Research paper (scientific journal)  

    EP4 prostanoid receptor (EP4R) contributes to the intestinal epithelial Cl- secretion, and inhibition of prostaglandin E (PGE) production by non-steroidal anti-inflammatory drugs (NSAIDs) plays a central role in NSAID-induced enteropathy. Although M3 muscarinic acetylcholine receptor (M3R) also contributes to the intestinal epithelial Cl- secretion, it remains unclear whether M3R is involved in NSAID-induced enteropathy due to a lack of selective agents. The present study explored how M3R is involved in the regulation of the intestinal epithelial Cl- secretion and its pathophysiological role in NSAID-induced enteropathy. Using the novel highly-selective M3 positive allosteric modulator PAM-369 that we recently developed, we evaluated the role of M3R in the intestinal epithelial secretion ex vivo by measuring the short circuit current (Isc) of intestinal epithelium with a Ussing chamber system and examined whether or not M3R protects against small intestinal injury in indomethacin-treated mice. Both the PGE1 derivative misoprostol and carbachol similarly increased the Isc in a concentration-dependent manner. The Isc increases were abolished either by receptor antagonists (an EP4R antagonist and a M3R antagonist, respectively) or by removal of extracellular Cl-. PAM-369 enhanced the carbachol-induced Isc by potentiating M3R, which could contribute to enhanced intestinal epithelial secretion. Treatment with PAM-369 ameliorated small intestinal injury in indomethacin-treated mice. Importantly, the M3R expression was significantly up-regulated, and PAM-369 potentiation of M3R was augmented in indomethacin-treated mice compared to untreated mice. These findings show that M3R plays a role in maintaining the intestinal epithelial secretion, which could contribute to protection against indomethacin-induced small intestinal injury. M3R is a promising target for treating or preventing NSAID-induced enteropathy. KEY MESSAGES: PAM-369, the M3 positive allosteric modulator, was used to potentiate M3R. PAM-369 enhanced carbachol-induced Isc in mouse ileum. PAM-369 ameliorated small intestinal injury in indomethacin-treated mice. M3R is a promising target for treating or preventing NSAID-induced enteropathy.

    DOI： 10.1007/s00109-024-02474-0

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  • Evidence-based clinical guidelines for chronic constipation 2023. International journal

    Eikichi Ihara, Noriaki Manabe, Hidenori Ohkubo, Naotaka Ogasawara, Haruei Ogino, Kazuki Kakimoto, Motoyori Kanazawa, Hidejiro Kawahara, Chika Kusano, Shiko Kuribayashi, Akinari Sawada, Tomohisa Takagi, Shota Takano, Toshihiko Tomita, Toshihiro Noake, Mariko Hojo, Ryota Hokari, Tatsuhiro Masaoka, Tomohiko Machida, Noboru Misawa, Yoshiyuki Mishima, Hiroshi Yajima, Sayuri Yamamoto, Hiroshi Yamawaki, Tatsuya Abe, Yasumi Araki, Kunio Kasugai, Takeshi Kamiya, Akira Torii, Atsushi Nakajima, Koji Nakada, Shin Fukudo, Yasuhiro Fujiwara, Hiroto Miwa, Hiromi Kataoka, Akihito Nagahara, Kazuhide Higuchi

    Digestion   2024.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    In July 2023 the Japan Gastroenterological Association published the first version of its clinical guidelines for chronic constipation 2023. Based on the latest evidence, these guidelines describe the definition, classification, diagnostic criteria, diagnostic testing methods, epidemiology, pathophysiology, and treatment of chronic constipation. They include flowcharts for both diagnosis and treatment of chronic constipation. In the treatment of chronic constipation, the first step involves differentiating between secondary forms, such as organic disease-associated constipation, systemic disease-associated constipation, and drug-induced constipation. The next step is to determine whether the chronic constipation stems from a motility disorder, a form of primary chronic constipation. For functional constipation and constipation-predominant irritable bowel syndrome, treatment should be initiated after evaluating symptoms like reduced frequency of bowel movement frequency type or defecation difficulty type. The first line of treatment includes improvement of lifestyle habits and diet therapy. The first drugs to consider for oral treatment are osmotic laxatives. If these are ineffective, secretagogues and ileal bile acid transporter inhibitors are candidates. However, stimulant laxatives are exclusively designated for as-needed use. Probiotics, bulk-forming laxatives, prokinetics, and Kampo medicine, for which there is insufficient evidence, are considered alternative or complementary therapy. Providing the best clinical strategies for chronic constipation therapy in Japan, these clinical guidelines for chronic constipation 2023 should prove useful for its treatment worldwide.

    DOI： 10.1159/000540912

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  • Comparison of hemostatic ability between spray coagulation and forced coagulation modes in endoscopic submucosal dissection in patients with early gastric neoplasms: a study protocol for multicenter randomized controlled trial (Spray-G trial). International journal

    Kosuke Maehara, Mitsuru Esaki, Yorinobu Sumida, Daisuke Yamaguchi, Kei Nishioka, Hitoshi Homma, Taisuke Inada, Kazuo Shiotsuki, Shin-Ichiro Fukuda, Hirotada Akiho, Tadahiro Nomura, Yumi Mizuta, Satoshi Ishida, Shun Fujimoto, Shunichiro Kimura, Yuichiro Tanaka, Kaori Hata, Noriko Shiga, Tsutomu Iwasa, Yusuke Kimura, Norimoto Nakamura, Yusuke Suzuki, Yosuke Minoda, Yoshitaka Hata, Haruei Ogino, Koshiro Tagawa, Eikichi Ihara, Yoshihiro Ogawa

    Trials   25 ( 1 )   53 - 53   2024.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s13063-023-07852-6

  • A Continuous Registry of Medical Record, Patient Input, and Epidemiological Data of Patients With Ulcerative Colitis: a Multicentre, Prospective, Observational Clinical Registry Study in Japan

    Matsuoka Katsuyoshi, Hibiya Shuji, Ando Katsuyoshi, Tani Yuji, Torisu Takehiro, Ogino Haruei, Yamashita Takanori, Andoh Akira, Sugimoto Yoshihisa, Matsumoto Takayuki, Iwanaga Yusuke, Suda Takashi, Kobayashi Taku

    Annals of Clinical Epidemiology   6 ( 3 )   65 - 72   2024   （ eISSN:24344338 ）

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    Language：English   Publisher：Society for Clinical Epidemiology  

    <p><b>BACKGROUND</b></p><p>This registry aims to allow for a prospective non-interventional observational study of ulcerative colitis. This will facilitate monitoring of the current state of ulcerative colitis in Japan and improving the long-term disease course and adverse events associated with current treatment options.</p><p><b>METHODS</b></p><p>Inclusion of patients from five centres in Japan is planned. The study is expected to take place from July 15, 2020, to November 30, 2024. Background, demographics, and medical history/information will be collected from electronic medical records at enrolment. Medical information including medications, laboratory data, and disease activity will be collected automatically from electronic medical records throughout the study. Patient-reported quality of life data will be collected directly from patients via smartphone. Efficacy endpoints (clinical remission rate, clinical improvement rate, and endoscopic healing rate) and safety endpoints (incidence of adverse events and specific ulcerative colitis-related events) will be collected according to treatment administered. Treatment categories include no treatment, 5-aminosalicylic acids, corticosteroids, immunomodulators, immunosuppressants, anti-tumour necrosis alpha agents, cytapheresis, Janus kinase inhibitors, anti-integrin antibodies, and anti-interleukin-12/23 antibodies.</p><p><b>CONCLUSIONS</b></p><p>The dataset will include cross-sectional and longitudinal data and is expected to capture the state of ulcerative colitis in Japan. Patients will be included on a large scale, and the registry will be established automatically from electronic medical records and direct patient input, facilitating the accurate recording of medical information for patients with ulcerative colitis in Japan and minimizing limitations intrinsic to databases that require manual data entry, such as the burden on participating investigators and entry of data with errors/typos.</p>

    DOI： 10.37737/ace.24010

    PubMed

    CiNii Research

  • Development of a new endoscopy system to visualize bilirubin for the diagnosis of duodenogastroesophageal reflux. International journal

    Masafumi Wada, Yosuke Minoda, Eikichi Ihara, Hirotaka Tsuru, Yoshitaka Hata, Shuzaburo Nagatomo, Mitsuru Esaki, Xiaopeng Bai, Yoshimasa Tanaka, Takatoshi Chinen, Haruei Ogino, Yoshihiro Ogawa

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   2023.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/den.14749

  • Two-step traction-assisted endoscopic submucosal dissection for a gastric neoplasm using a clip with a traction band and thread. International journal

    Kei Nishioka, Mitsuru Esaki, Tsutomu Iwasa, Yosuke Minoda, Noriko Shiga, Haruei Ogino, Eikichi Ihara

    Endoscopy   55 ( S 01 )   E1041-E1042   2023.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1055/a-2155-7172

  • Two-point fixed pulley-traction method in endoscopic submucosal dissection for early gastric neoplasm. International journal

    Tsubasa Takeuchi, Mitsuru Esaki, Yosuke Minoda, Yoshitaka Hata, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa

    Endoscopy   55 ( S 01 )   E1087-E1088   2023.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1055/a-2173-8010

  • Circumferential suture delivery method of polyglycolic acid sheets for gastric postendoscopic submucosal dissection ulcers. International journal

    Yusuke Suzuki, Takashi Osoegawa, Masaru Kubokawa, Mitsuru Esaki, Yosuke Minoda, Haruei Ogino, Eikichi Ihara

    Endoscopy   55 ( S 01 )   E68-E69   2023.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1055/a-1934-9752

  • Evaluating the efficacy and safety of acotiamide in patients with esophagogastric junction outflow obstruction: study protocol for an investigator-initiated, multi-center, randomized, double-blind, placebo-controlled phase II trial. International journal

    Mitsuru Esaki, Eikichi Ihara, Noriaki Manabe, Noriyuki Kawami, Katsuhiko Iwakiri, Junichi Akiyama, Shiko Kuribayashi, Toshio Uraoka, Haruei Ogino, Takatoshi Chinen, Akiko Misumi, Hiroko Watanabe, Maya Suzuki, Junji Kishimoto, Yoshihiro Ogawa

    Trials   24 ( 1 )   459 - 459   2023.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s13063-023-07468-w

  • Hybrid and Conventional Endoscopic Submucosal Dissection for Early Gastric Neoplasms: A Multi-Center Randomized Controlled Trial. International journal

    Mitsuru Esaki, Eikichi Ihara, Yorinobu Sumida, Hiroyuki Fujii, Shunsuke Takahashi, Kazuhiro Haraguchi, Tsutomu Iwasa, Shinichi Somada, Yosuke Minoda, Haruei Ogino, Koshiro Tagawa, Yoshihiro Ogawa

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association   21 ( 7 )   1810 - 1818   2023.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.cgh.2022.10.030

  • TRACTION-ASSISTED ENDOSCOPIC ULTRASOUND-GUIDED FINE-NEEDLE BIOPSY USING THE CLIP-WITH-THREAD METHOD FOR SMALL GASTRIC SUBEPITHELIAL LESIONS: A RANDOMIZED CONTROL TRIAL

    Suzuki, Y; Minoda, Y; Ihara, E; Fujimori, N; Nagatomo, S; Ueda, K; Esaki, M; Ogino, H; Ogawa, Y

    GASTROINTESTINAL ENDOSCOPY   97 ( 6 )   AB805 - AB806   2023.6   （ ISSN:0016-5107 eISSN:1097-6779 ）

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  • Auxiliary diagnosis of subepithelial lesions by impedance measurement during EUS-guided fine-needle biopsy. International journal

    Yosuke Minoda, Mitsuru Esaki, Eikichi Ihara, Shuzaburo Nagatomo, Kei Nishioka, Nao Fujimori, Haruei Ogino, Xiaopeng Bai, Yoshimasa Tanaka, Takatoshi Chinen, Qingjiang Hu, Mitsuhiko Ota, Shinya Umekita, Hidetaka Yamamoto, Yoshihiro Ogawa

    Gastrointestinal endoscopy   97 ( 5 )   977 - 984   2023.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.gie.2022.11.022

  • Determination of Region-Specific Roles of the M3 Muscarinic Acetylcholine Receptor in Gastrointestinal Motility. International journal

    Yoko Igarashi-Hisayoshi, Eikichi Ihara, Xiaopeng Bai, Chika Higashi, Hiroko Ikeda, Yoshimasa Tanaka, Mayumi Hirano, Haruei Ogino, Takatoshi Chinen, Yasushi Taguchi, Yoshihiro Ogawa

    Digestive diseases and sciences   68 ( 2 )   439 - 450   2023.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10620-022-07637-y

  • Negligible procedure-related dissemination risk of mucosal incision-assisted biopsy for gastrointestinal stromal tumors versus endoscopic ultrasound-guided fine-needle aspiration/biopsy. International journal

    Yosuke Minoda, Eikichi Ihara, Soichi Itaba, Yorinobu Sumida, Kazuhiro Haraguchi, Akira Aso, Takahiro Mizutani, Takashi Osoegawa, Mitsuru Esaki, Shuzaburo Nagatomo, Kei Nishioka, Kazumasa Muta, Xiaopeng Bai, Haruei Ogino, Nao Fujimori, Daisuke Tsurumaru, Kenoki Ohuchida, Hu Qingjiang, Eiji Oki, Hidetaka Yamamoto, Yoshihiro Ogawa

    Surgical endoscopy   37 ( 1 )   101 - 108   2023.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00464-022-09419-z

  • Gastric endoscopic submucosal dissection assisted by intralesional cross-traction using silicone bands. International journal

    Yusuke Suzuki, Mitsuru Esaki, Taisuke Inada, Yosuke Minoda, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa

    Endoscopy   55 ( S 01 )   E324-E325   2022.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1055/a-1982-3875

  • Auxiliary diagnosis of subepithelial lesions by impedance measurement during endoscopic ultrasound guided fine-needle biopsy. International journal

    Yosuke Minoda, Mitsuru Esaki, Eikichi Ihara, Shuzaburo Nagatomo, Kei Nishioka, Nao Fujimori, Haruei Ogino, Xiaopeng Bai, Yoshimasa Tanaka, Takatoshi Chinen, Qingjiang Hu, Mitsuhiko Ota, Shinya Umekita, Hidetaka Yamamoto, Yoshihiro Ogawa

    Gastrointestinal endoscopy   97 ( 5 )   977 - 984   2022.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.gie.2022.11.022

  • Hybrid- and conventional endoscopic submucosal dissection for early gastric neoplasms: a multi-center randomized controlled trial. International journal

    Mitsuru Esaki, Eikichi Ihara, Yorinobu Sumida, Hiroyuki Fujii, Shunsuke Takahashi, Kazuhiro Haraguchi, Tsutomu Iwasa, Shinichi Somada, Yosuke Minoda, Haruei Ogino, Koshiro Tagawa, Yoshihiro Ogawa

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association   21 ( 7 )   1810 - 1818   2022.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.cgh.2022.10.030

  • Efficacy of ultrasound endoscopy with artificial intelligence for the differential diagnosis of non-gastric gastrointestinal stromal tumors. International journal

    Yosuke Minoda, Eikichi Ihara, Nao Fujimori, Shuzaburo Nagatomo, Mitsuru Esaki, Yoshitaka Hata, Xiaopeng Bai, Yoshimasa Tanaka, Haruei Ogino, Takatoshi Chinen, Qingjiang Hu, Eiji Oki, Hidetaka Yamamoto, Yoshihiro Ogawa

    Scientific reports   12 ( 1 )   16640 - 16640   2022.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-022-20863-8

  • Circumferential suture delivery method of polyglycolic acid sheets for gastric postendoscopic submucosal dissection ulcers. International journal

    Yusuke Suzuki, Takashi Osoegawa, Masaru Kubokawa, Mitsuru Esaki, Yosuke Minoda, Haruei Ogino, Eikichi Ihara

    Endoscopy   2022.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1055/a-1934-9752

  • Determination of Region-Specific Roles of the M3 Muscarinic Acetylcholine Receptor in Gastrointestinal Motility. International journal

    Yoko Igarashi-Hisayoshi, Eikichi Ihara, Xiaopeng Bai, Chika Higashi, Hiroko Ikeda, Yoshimasa Tanaka, Mayumi Hirano, Haruei Ogino, Takatoshi Chinen, Yasushi Taguchi, Yoshihiro Ogawa

    Digestive diseases and sciences   68 ( 2 )   439 - 450   2022.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10620-022-07637-y

  • Improved esophagography screening for esophageal motility disorders using wave appearance and supra-junctional ballooning.

    Yoshitaka Hata, Eikichi Ihara, Masafumi Wada, Hirotaka Tsuru, Kazumasa Muta, Yosuke Minoda, Xiaopeng Bai, Mitsuru Esaki, Yoshimasa Tanaka, Takatoshi Chinen, Haruei Ogino, Ryuichi Sakamoto, Yoshihiro Ogawa

    Journal of gastroenterology   57 ( 11 )   838 - 847   2022.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00535-022-01913-4

  • Negligible procedure-related dissemination risk of mucosal incision-assisted biopsy for gastrointestinal stromal tumors versus endoscopic ultrasound-guided fine-needle aspiration/biopsy. International journal

    Yosuke Minoda, Eikichi Ihara, Soichi Itaba, Yorinobu Sumida, Kazuhiro Haraguchi, Akira Aso, Takahiro Mizutani, Takashi Osoegawa, Mitsuru Esaki, Shuzaburo Nagatomo, Kei Nishioka, Kazumasa Muta, Xiaopeng Bai, Haruei Ogino, Nao Fujimori, Daisuke Tsurumaru, Kenoki Ohuchida, Hu Qingjiang, Eiji Oki, Hidetaka Yamamoto, Yoshihiro Ogawa

    Surgical endoscopy   37 ( 1 )   101 - 108   2022.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00464-022-09419-z

  • Innovative endoscopic submucosal dissection for early gastric neoplasm using intralesional traction and snaring techniques. International journal

    Yoshihisa Shoguchi, Mitsuru Esaki, Yosuke Minoda, Xiaopeng Bai, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa

    Endoscopy   2022.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1055/a-1841-5907

  • Application of intralesional traction assistance with traction wire to endoscopic submucosal dissection for colorectal neoplasms. International journal

    Takayuki Nasu, Mitsuru Esaki, Yoshihisa Shoguchi, Xiaopeng Bai, Yosuke Minoda, Haruei Ogino, Eikichi Ihara

    Endoscopy   2022.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1055/a-1809-4967

  • Comparisons of outcomes between ProKnife injection endoscopic submucosal dissection and conventional endoscopic submucosal dissection for large gastric lesions in ex vivo porcine model study: A randomized controlled trial. International journal

    Mitsuru Esaki, Eikichi Ihara, Misato Esaki, Kei Nishioka, Yusuke Kimura, Yoshitaka Hata, Hirotaka Tsuru, Masafumi Wada, Yosuke Minoda, Xiaopeng Bai, Yoshihisa Shoguchi, Takayuki Nasu, Shuzaburo Nagatomo, Kazumasa Muta, Haruei Ogino, Yoshihiro Ogawa

    DEN open   2 ( 1 )   e91   2022.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/deo2.91

  • Validation of a claims-based algorithm to identify cases of ulcerative colitis in Japan

    Ogino, H; Morikubo, H; Fukaura, K; Okui, T; Gardiner, S; Sugiyama, N; Yoshii, N; Kawaguchi, T; Chen, HQ; Nonnenmacher, E; Setoguchi, S; Nakashima, N; Kobayashi, T

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   37 ( 3 )   499 - 506   2022.3   （ ISSN:0815-9319 eISSN:1440-1746 ）

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    Language：English   Publisher：Journal of Gastroenterology and Hepatology (Australia)  

    Background and Aim: The prevalence of ulcerative colitis (UC) is increasing in Japan. Validated claims-based definitions are required to investigate the epidemiology of UC and its treatment and disease course in clinical practice. This study aimed to develop a claims-based algorithm for UC in Japan. Methods: A committee of epidemiologists, gastroenterologists, and internal medicine physicians developed a claims-based definition for UC, based on diagnostic codes and claims for UC treatments, procedures (cytapheresis), or surgery (postoperative claims). Claims data and medical records for a random sample of 200 cases per site at two large tertiary care academic centers in Japan were used to calculate the positive predictive value (PPV) of the algorithm for three gold standards of diagnosis, defined as physician diagnosis in the medical records, adjudicated cases, or registration in the Japanese Intractable Disease Registry (IDR). Results: Overall, 1139 claims-defined UC cases were identified. Among 393 randomly sampled cases (mean age 44; 48% female), 94% had received ≥ 1 systemic treatment (immunosuppressants, tumor necrosis factor inhibitors, corticosteroids, or antidiarrheals), 7% had cytapheresis, and 7% had postoperative claims. When physician diagnosis was used as a gold standard, PPV was 90.6% (95% confidence interval [CI]: 87.7–93.5). PPV with expert adjudication was also 90.6% (95% CI: 87.7–93.5). PPVs with enrollment in the IDR as gold standard were lower at 41.5% (95% CI: 36.6–46.3) due to incomplete case registration. Conclusions: The claims-based algorithm developed for use in Japan is likely to identify UC cases with high PPV for clinical studies using administrative claims databases.

    DOI： 10.1111/jgh.15732

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    PubMed

  • Comparison of the procedure time differences between hybrid endoscopic submucosal dissection and conventional endoscopic submucosal dissection in patients with early gastric neoplasms: a study protocol for a multi-center randomized controlled trial (Hybrid-G trial). International journal

    Mitsuru Esaki, Eikichi Ihara, Hiroyuki Fujii, Yorinobu Sumida, Kazuhiro Haraguchi, Shunsuke Takahashi, Tsutomu Iwasa, Kayoko Nakano, Masafumi Wada, Shinichi Somada, Yosuke Minoda, Haruei Ogino, Koshiro Tagawa, Yoshihiro Ogawa

    Trials   23 ( 1 )   166 - 166   2022.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s13063-022-06099-x

  • Is a small-caliber or large-caliber endoscope more suitable for colonic self-expandable metallic stent placement? A randomized controlled study. International journal

    Yosuke Minoda, Haruei Ogino, Yorinobu Sumida, Takashi Osoegawa, Soichi Itaba, Norikazu Hashimoto, Mitsuru Esaki, Yusuke Kitagawa, Kentaro Yodoe, Yoichiro Iboshi, Takahiro Matsuguchi, Mei Tadokoro, Tomohito Chaen, Hiroaki Kubo, Masaru Kubokawa, Naohiko Harada, Kenichi Nishizima, Hiroyuki Fujii, Yoshitaka Hata, Yoshimasa Tanaka, Eikichi Ihara, Yoshihiro Ogawa

    Therapeutic advances in gastroenterology   15   17562848211065331 - 17562848211065331   2022.1   （ ISSN:1756-283X eISSN:1756-2848 ）

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    Objectives: The colonic self-expandable metallic stent (C-SEMS) with a 9-French (Fr) delivery system allows for a small-caliber endoscope (SCE) to be used to treat malignant colonic obstruction. Despite the lack of evidence, the SCE has become popular because it is considered easier to insert than the large-caliber endoscope (LCE). We aimed to determine whether the SCE is more suitable than the LCE for C-SEMS placement. Methods: Between July 2018 and November 2019, 50 consecutive patients who were scheduled to undergo C-SEMS for colon obstruction were recruited in this study. Patients were randomized to the SCE or LCE group. The SCE and LCE were used with 9-Fr and 10-Fr delivery systems, respectively. The primary outcome was the total procedure time. Secondary outcomes were the technical success rate, complication rate, clinical success rate, insertion time, guidewire-passage time, stent-deployment time, and colonic obstruction-scoring-system score. Results: Forty-five patients (SCE group, n = 22; LCE group, n = 23) were analyzed. The procedure time in the LCE group (median, 20.5 min) was significantly (p = 0.024) shorter than that in the SCE group (median, 25.1 min). The insertion time in the LCE group (median, 2.0 min) was significantly (p = 0.0049) shorter than that in the SCE group (median, 6.0 min). A sub-analysis of the procedure difficulties showed that the insertion time in the LCE group (median, 5.0 min) was significantly shorter than that in the SCE group (median, 8.5 min). Conclusion: Both LCE and SCE can be used for C-SEMS; however, LCE is more suitable than SCE as it achieved a faster and equally efficacious C-SEMS placement as that of SCE. Clinical trial registration number: University Hospital Medical Information Network Clinical Trials Registry (UMIN 32748).

    DOI： 10.1177/17562848211065331

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  • 十二指腸非乳頭部腫瘍診療における課題と治療戦略 胃型の非乳頭部十二指腸腫瘍に対する内視鏡治療の現状と選択

    蓑田 洋介, 伊原 栄吉, 山元 英崇, 江崎 充, 畑 佳孝, 佐々木 泰介, 荻野 治栄, 小川 佳宏

    日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集   118回・112回   92 - 92   2021.12

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  • Involvement of interstitial cells of Cajal in nicotinic acetylcholine receptor-induced relaxation of the porcine lower esophageal sphincter. International journal

    Yoshihiro Otsuka, Xiaopeng Bai, Yoshimasa Tanaka, Eikichi Ihara, Takatoshi Chinen, Haruei Ogino, Yoshihiro Ogawa

    European journal of pharmacology   910   174491 - 174491   2021.11

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    DOI： 10.1016/j.ejphar.2021.174491

  • Rubber band-assisted, one-person-operated cold snare polypectomy for colorectal polyps. International journal

    Misato Esaki, Mitsuru Esaki, Kosuke Maehara, Yosuke Minoda, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa

    Endoscopy international open   9 ( 11 )   E1845-E1846   2021.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1055/a-1576-7673

  • Traction-assisted hybrid endoscopic submucosal dissection for small rectal neuroendocrine tumors. International journal

    Takayuki Nasu, Mitsuru Esaki, Yoshihisa Shoguchi, Xiaopeng Bai, Yosuke Minoda, Haruei Ogino, Eikichi Ihara

    Endoscopy   2021.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1055/a-1662-4965

  • The treatment effects of acotiamide in esophagogastric outflow obstruction: a prospective longitudinal observational study.

    Eikichi Ihara, Haruei Ogino, Kazumasa Muta, Shohei Hamada, Masafumi Wada, Yoshitaka Hata, Hiroko Ikeda, Xiaopeng Bai, Yosuke Minoda, Mitsuru Esaki, Yoshimasa Tanaka, Takatoshi Chinen, Yoshihiro Ogawa

    Esophagus : official journal of the Japan Esophageal Society   19 ( 2 )   332 - 342   2021.10

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    DOI： 10.1007/s10388-021-00887-1

  • 【膵と胆道の先天性形成異常～発生から臨床まで～】異所性膵の診断

    蓑田 洋介, 長友 周三郎, 西岡 慧, 江崎 充, 荻野 治栄, 藤森 尚, 大野 隆真, 伊原 栄吉, 大久保 文彦, 佐々木 泰介, 小田 義直, 小川 佳宏

    胆と膵   42 ( 10 )   943 - 946   2021.10

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    異所性膵は胃角部から前庭部に多く発生する消化管粘膜下腫瘍として見つかることが多い疾患である。多くの異所性膵は良性で経過し診断がつけば基本的には経過観察が可能である。診断は上部消化管内視鏡検査ならびに超音波内視鏡を用いた画像診断や病理学的評価が有用とされている。超音波内視鏡による画像診断は非常に有用であるが、内部の性状だけでなく病変の由来層の確認が極めて重要である。また超音波内視鏡下吸引穿刺細胞診/生検以外の診断法として近年報告が増えている粘膜切開生検が、EUS-FNABで診断困難な症例における新たな診断オプションとして期待される。(著者抄録)

  • Usefulness of a gel immersion-assisted EUS-guided fine-needle aspiration/biopsy for ampullary lesions (with videos). International journal

    Yosuke Minoda, Shuzaburo Nagatomo, Nao Fujimori, Kei Nishioka, Shotaro Kakehashi, Katsuhito Teramatsu, Yu Takamatsu, Haruei Ogino, Eikichi Ihara

    Endoscopic ultrasound   2021.9

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    DOI： 10.4103/EUS-D-21-00043

  • Mucosal IL23A expression predicts the response to Ustekinumab in inflammatory bowel disease.

    Kei Nishioka, Haruei Ogino, Takatoshi Chinen, Eikichi Ihara, Yoshimasa Tanaka, Kazuhiko Nakamura, Yoshihiro Ogawa

    Journal of gastroenterology   56 ( 11 )   976 - 987   2021.8

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    DOI： 10.1007/s00535-021-01819-7

  • Mucosa-associated gut microbiota reflects clinical course of ulcerative colitis. International journal

    Yuichiro Nishihara, Haruei Ogino, Masaru Tanaka, Eikichi Ihara, Keita Fukaura, Kei Nishioka, Takatoshi Chinen, Yoshimasa Tanaka, Jiro Nakayama, Dongchon Kang, Yoshihiro Ogawa

    Scientific reports   11 ( 1 )   13743 - 13743   2021.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-021-92870-0

  • Onigiri esophagography as a screening test for esophageal motility disorders. International journal

    Shohei Hamada, Eikichi Ihara, Kazumasa Muta, Masafumi Wada, Yoshitaka Hata, Hiroko Ikeda, Yoshimasa Tanaka, Haruei Ogino, Takatoshi Chinen, Yoshihiro Ogawa

    Journal of neurogastroenterology and motility   28 ( 1 )   43 - 52   2021.7

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    DOI： 10.5056/jnm20138

  • Efficacy of hybrid endoscopic submucosal dissection with SOUTEN in gastric lesions: An ex vivo porcine model basic study. International journal

    Mitsuru Esaki, Eikichi Ihara, Norikazu Hashimoto, Shuichi Abe, Chihoko Aratono, Noriko Shiga, Yorinobu Sumida, Hiroyuki Fujii, Kazuhiro Haraguchi, Shunsuke Takahashi, Tsutomu Iwasa, Kayoko Nakano, Masafumi Wada, Shinichi Somada, Kei Nishioka, Yosuke Minoda, Haruei Ogino, Yoshihiro Ogawa

    World journal of gastrointestinal surgery   13 ( 6 )   563 - 573   2021.6

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    DOI： 10.4240/wjgs.v13.i6.563

  • 膵・消化管領域における診断的EUSとEUS-FNAの現状と展望 十二指腸粘膜下腫瘍に対する人工知能併用超音波内視鏡画像診断の有用性

    蓑田 洋介, 長友 周三郎, 藤森 尚, 荻野 治栄, 伊原 栄吉

    日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集   117回・111回   99 - 99   2021.6

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  • 内視鏡的に除去しえた自然脱落型膵管ステントのS状結憩室嵌頓の一例

    長友 周三郎, 蓑田 洋介, 藤森 尚, 梯 祥太郎, 江崎 珠里, 大塚 宜寛, 池田 浩子, 西岡 慧, 高松 悠, 寺松 克人, 荻野 治栄, 大野 隆真, 伊原 栄吉

    日本消化器病学会九州支部例会・日本消化器内視鏡学会九州支部例会プログラム・抄録集   117回・111回   168 - 168   2021.6

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  • Application of traction-method to hybrid endoscopic submucosal dissection for gastrointestinal tumors. International journal

    Mitsuru Esaki, Ryosuke Maehara, Shuzaburo Nagatomo, Kei Nishioka, Yosuke Minoda, Haruei Ogino, Eikichi Ihara

    Endoscopy   2021.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1055/a-1422-2902

  • Physiological and pathological roles of the accommodation response in lower esophageal sphincter relaxation during wet swallows. International journal

    Kazumasa Muta, Eikichi Ihara, Shohei Hamada, Hiroko Ikeda, Masafumi Wada, Yoshitaka Hata, Xiaopeng Bai, Yuichiro Nishihara, Yoshimasa Tanaka, Haruei Ogino, Yoshihiro Ogawa

    Scientific reports   11 ( 1 )   7898 - 7898   2021.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-021-87052-x

  • Discriminant equation using mucosally expressed cytokines and transcription factor for making definite diagnosis of inflammatory bowel disease unclassified. International journal

    Hiroaki Okuno, Haruei Ogino, Eikichi Ihara, Kei Nishioka, Yoshimasa Tanaka, Takatoshi Chinen, Motoyuki Kohjima, Takamasa Oono, Masatake Tanaka, Takeshi Goya, Nao Fujimori, Yoichiro Iboshi, Takuji Gotoda, Yoshihiro Ogawa

    BMC gastroenterology   21 ( 1 )   73 - 73   2021.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s12876-021-01656-1

  • Efficacy of endoscopic ultrasound with artificial intelligence for the diagnosis of gastrointestinal stromal tumors.

    Yosuke Minoda, Eikichi Ihara, Keishi Komori, Haruei Ogino, Yoshihiro Otsuka, Takatoshi Chinen, Yasuo Tsuda, Koji Ando, Hidetaka Yamamoto, Yoshihiro Ogawa

    Journal of gastroenterology   55 ( 12 )   1119 - 1126   2020.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00535-020-01725-4

  • Role of the IL-23-T-bet/GATA3 Axis for the Pathogenesis of Ulcerative Colitis. International journal

    Haruei Ogino, Keita Fukaura, Yoichiro Iboshi, Yousuke Nagamatsu, Hiroaki Okuno, Kei Nishioka, Yuichiro Nishihara, Yoshimasa Tanaka, Takatoshi Chinen, Eikich Ihara, Yoshihiro Ogawa

    Inflammation   2020.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10753-020-01358-y

  • Endoscopic mucosal resection vs endoscopic submucosal dissection for superficial non-ampullary duodenal tumors. International journal

    Mitsuru Esaki, Kazuhiro Haraguchi, Kazuya Akahoshi, Naru Tomoeda, Akira Aso, Soichi Itaba, Haruei Ogino, Yusuke Kitagawa, Hiroyuki Fujii, Kazuhiko Nakamura, Masaru Kubokawa, Naohiko Harada, Yosuke Minoda, Sho Suzuki, Eikichi Ihara, Yoshihiro Ogawa

    World journal of gastrointestinal oncology   12 ( 8 )   918 - 930   2020.8

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    DOI： 10.4251/wjgo.v12.i8.918

  • Interleukin-1β as a Predictor of Glucocorticoid Response in Ulcerative Colitis. International journal

    1 - 11   2020.5

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    BACKGROUND/AIM: Currently, there are no established biomarkers to differentiate between glucocorticoid (GC)-resistant and GC-sensitive ulcerative colitis (UC); however, interleukin (IL)-1β could be one such candidate biomarker. The aim of this study was to investigate whether mucosally expressed IL-1β could predict the response to GC in patients with UC. METHODS: A total of 27 mucosal tissue samples from 10 patients with GC-resistant UC (GC-resistant group), 9 patients with GC-sensitive UC (GC-sensitive group), and 8 control patients (control group) were analyzed by qRT-PCR for the expression of IL-1β, GC receptor α (GRα), GRβ, and other inflammatory mediators. Rachmilewitz endoscopic index (REI) between the GC-resistant and GC-sensitive groups was matched to avoid any potential influence of inflammation. RESULTS: The REI did not significantly differ between the GC-resistant and GC-sensitive groups. Mucosally expressed IL-1β levels in the GC-resistant group were significantly higher than those in the GC-sensitive group. However, there were no significant differences in the expression levels of GRα, GRβ, and other inflammatory mediators between the 2 groups. We could distinguish between the GC-resistant and GC-sensitive groups with a sensitivity of 90.0% and specificity of 77.8% based on mucosally expressed IL-1β. CONCLUSIONS: Mucosally expressed IL-1β can be used as a predictor of GC response in patients with UC.

    DOI： 10.1159/000507435

  • The Efficacy and Safety of a Promising Single-Channel Endoscopic Closure Technique for Endoscopic Treatment-Related Artificial Ulcers: A Pilot Study. International journal

    Yosuke Minoda, Eikichi Ihara, Haruei Ogino, Keishi Komori, Yoshihiro Otsuka, Hiroko Ikeda, Mitsuru Esaki, Takatoshi Chinen, Takahiro Matsuguchi, Shunsuke Takahashi, Noriko Shiga, Rie Yoshimura, Yoshihiro Ogawa

    Gastrointestinal tumors   7 ( 1-2 )   21 - 29   2020.4

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    DOI： 10.1159/000503994

  • Superiority of mucosal incision-assisted biopsy over ultrasound-guided fine needle aspiration biopsy in diagnosing small gastric subepithelial lesions: a propensity score matching analysis. International journal

    Yosuke Minoda, Takatoshi Chinen, Takashi Osoegawa, Soichi Itaba, Kazuhiro Haraguchi, Hirotada Akiho, Akira Aso, Yorinobu Sumida, Keishi Komori, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa

    BMC gastroenterology   20 ( 1 )   19 - 19   2020.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s12876-020-1170-2

  • Clinical Characterization of Vonoprazan-Refractory Gastroesophageal Reflux Disease. Reviewed International journal

    Shohei Hamada, Eikichi Ihara, Hiroko Ikeda, Kazumasa Muta, Haruei Ogino, Takatoshi Chinen, Yoshimasa Tanaka, Yoshihiro Ogawa

    Digestion   102 ( 2 )   1 - 8   2019.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000503340

  • Involvement of different receptor subtypes in prostaglandin E2-induced contraction and relaxation in the lower esophageal sphincter and esophageal body Reviewed

    Xiaopeng Bai, Eikichi Ihara, Yoshihihro Otsuka, Shinichi Tsuruta, Katsuya Hirano, Yoshimasa Tanaka, Haruei Ogino, Mayumi Hirano, Takatoshi Chinen, Hirotada Akiho, Kazuhiko Nakamura, Yoshinao Oda, Yoshihiro Ogawa

    European Journal of Pharmacology   857   2019.8

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    DOI： 10.1016/j.ejphar.2019.172405

  • Mucosal Profiles of Immune Molecules Related to T Helper and Regulatory T Cells Predict Future Relapse in Patients With Quiescent Ulcerative Colitis Reviewed International journal

    Keita Fukaura, Yoichiro Iboshi, Haruei Ogino, Eikichi Ihara, Kazuhiko Nakamura, Yuichiro Nishihara, Kei Nishioka, Takatoshi Chinen, Tsutomu Iwasa, Akira Aso, Ayako Goto, Kazuhiro Haraguchi, Hirotada Akiho, Naohiko Harada, Yoshihiro Ogawa

    Inflammatory bowel diseases   25 ( 6 )   1019 - 1027   2019.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/ibd/izy395

  • INTERSTITIAL CELLS OF CAJAL PLAY A CRUCIAL ROLE IN THE NEUROTRANSMISSION OF NICOTINIC ACETYLCHOLINE RECEPTOR IN PORCINE LOWER ESOPHAGEAL SPHINCTER

    Yoshihiro Otsuka, Eikichi ihara, Xiaopeng Bai, Takatoshi Chinen, Haruei Ogino, Hirotada Akiho, Yoshihiro Ogawa

    GASTROENTEROLOGY   156 ( 6 )   S539 - S539   2019.5

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  • The Altered Mucosal Barrier Function in the Duodenum Plays a Role in the Pathogenesis of Functional Dyspepsia Reviewed International journal

    Keishi Komori, Eikichi Ihara, Yosuke Minoda, Haruei Ogino, Taisuke Sasaki, Minako Fujiwara, Yoshinao Oda, Yoshihiro Ogawa

    Digestive Diseases and Sciences   64 ( 11 )   3228 - 3239   2019.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10620-019-5470-8

  • Objective validity of the Japan Narrow-Band Imaging Expert Team classification system for the differential diagnosis of colorectal polyps Reviewed International journal

    Yosuke Minoda, Haruei Ogino, Takatoshi Chinen, Eikichi Ihara, Kazuhiro Haraguchi, Hirotada Akiho, Nobuyoshi Takizawa, Akira Aso, Yosuke Tomita, Mitsuru Esaki, Keishi Komori, Yoshihiro Otsuka, Tsutomu Iwasa, Yoshihiro Ogawa

    Digestive Endoscopy   31 ( 5 )   544 - 551   2019.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/den.13393

  • Mucosal incision-assisted biopsy versus endoscopic ultrasound-guided fine-needle aspiration with a rapid on-site evaluation for gastric subepithelial lesions A randomized cross-over study Reviewed International journal

    Takashi Osoegawa, Yosuke Minoda, Eikichi Ihara, Keishi Komori, Aso Akira, Ayako Goto, Soichi Itaba, Haruei Ogino, Kazuhiko Nakamura, Naohiko Harada, Kosuke Makihara, Shinichi Tsuruta, Hidetaka Yamamoto, Yoshihiro Ogawa

    Digestive Endoscopy   31 ( 4 )   413 - 421   2019.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/den.13367

  • Clutch Cutter knife efficacy in endoscopic submucosal dissection for early gastric neoplasms Reviewed International journal

    Yasuyo Hayashi, Mitsuru Esaki, Sho Suzuki, Eikichi Ihara, Azusa Yokoyama, Seiichiro Sakisaka, Taizo Hosokawa, Yoshimasa Tanaka, Takahiro Mizutani, Shinichi Tsuruta, Aya Iwao, Shun Yamakawa, Akira Irie, Yosuke Minoda, Yoshitaka Hata, Haruei Ogino, Hirotada Akiho, Yoshihiro Ogawa

    World Journal of Gastrointestinal Oncology   10 ( 12 )   487 - 495   2018.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.4251/wjgo.v10.i12.487

  • Mucosally Expressed Cytokines are Associated with the Esophageal Motility Function Reviewed International journal

    Keita Fukaura, Eikichi Ihara, Haruei Ogino, Yoichiro Iboshi, Kazumasa Muta, Bai Xiaopeng, Shohei Hamada, Yoshitaka Hata, tsutomu iwasa, Akira Aso, Kazuhiko Nakamura, Yoshihiro Ogawa

    Digestion   98 ( 2 )   95 - 103   2018.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1159/000487708

  • Propensity score-matching analysis to compare clinical outcomes of endoscopic submucosal dissection for early gastric cancer in the postoperative and non-operative stomachs Reviewed International journal

    Mitsuru Esaki, Sho Suzuki, Yasuyo Hayashi, Azusa Yokoyama, Shuichi Abe, Taizo Hosokawa, Shinichi Tsuruta, Yosuke Minoda, Yoshitaka Hata, Haruei Ogino, Hirotada Akiho, Eikichi Ihara, Yoshihiro Ogawa

    BMC Gastroenterology   18 ( 1 )   125 - 125   2018.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s12876-018-0855-2

  • A new robotic-assisted flexible endoscope with single-hand control endoscopic submucosal dissection in the ex vivo porcine stomach Reviewed International journal

    tsutomu iwasa, Ryu Nakadate, Shinya Onogi, Yasuharu Okamoto, Jumpei Arata, Susumu Oguri, Haruei Ogino, Eikichi Ihara, Kenoki Ouchida, Tomohiko Akahoshi, Tetsuo Ikeda, Yoshihiro Ogawa, Makoto Hashizume

    Surgical Endoscopy   32 ( 7 )   3386 - 3392   2018.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s00464-018-6188-y

  • Recovery technique using a double scope to rescue failed primary endoscopic ligation Reviewed

    Yosuke Minoda, Keishi Komori, Ryoko Naruo, tsutomu iwasa, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa

    Endoscopy   50 ( 9 )   E244 - E245   2018.6

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    DOI： 10.1055/a-0631-7760

  • Endogenous Hydrogen Sulfide Contributes to Tone Generation in Porcine Lower Esophageal Sphincter Via Na+/Ca2+ Exchanger Reviewed

    Xiaopeng Bai, Eikichi Ihara, Katsuya Hirano, Yoshimasa Tanaka, Kayoko Nakano, Satomi Kita, Takahiro Iwamoto, Haruei Ogino, Mayumi Hirano, Yoshinao Oda, Kazuhiko Nakamura, Yoshihiro Ogawa

    CMGH   5 ( 3 )   209 - 221   2018.3

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    DOI： 10.1016/j.jcmgh.2017.11.004

  • Splash M-knife versus Flush Knife BT in the technical outcomes of endoscopic submucosal dissection for early gastric cancer A propensity score matching analysis Reviewed International journal

    Mitsuru Esaki, Sho Suzuki, Yasuyo Hayashi, Azusa Yokoyama, Shuichi Abe, Taizo Hosokawa, Haruei Ogino, Hirotada Akiho, Eikichi Ihara, Yoshihiro Ogawa

    BMC Gastroenterology   18 ( 1 )   35 - 35   2018.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s12876-018-0763-5

  • Splash M-knife versus Flush Knife BT in the technical outcomes of endoscopic submucosal dissection for early gastric cancer: a propensity score matching analysis. Reviewed International journal

    Esaki M, Suzuki S, Hayashi Y, Yokoyama A, Abe S, Hosokawa T, Ogino H, Akiho H, Ihara E, Ogawa Y.

    BMC gastroenterology   18 ( 1 )   35 - 35   2018.2

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    DOI： 10.1186/s12876-018-0763-5

  • A case of non-cardiac chest pain caused by esophageal motility disorder observed on esophageal high-resolution manometry Reviewed

    Kazumasa Muta, Eikichi Ihara, Yusuke Kitagawa, Shohei Hamada, Keita Fukaura, tsutomu iwasa, Akira Aso, Haruei Ogino, Kazuhiko Nakamura, Yoshihiro Ogawa

    Journal of Japanese Society of Gastroenterology   115 ( 4 )   401 - 408   2018.1

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    DOI： 10.11405/nisshoshi.115.401

  • Endogenous Hydrogen Sulfide Contributes to Tone Generation in Porcine Lower Esophageal Sphincter Via Na+/Ca2+ Exchanger. Reviewed International journal

    Bai X, Ihara E, Hirano K, Tanaka Y, Nakano K, Kita S, Iwamoto T, Ogino H, Hirano M, Oda Y, Nakamura K, Ogawa Y.

    Cell Mol Gastroenterol Hepatol.   2017.11

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  • Increased IL-17A/IL-17F expression ratio represents the key mucosal T helper/regulatory cell-related gene signature paralleling disease activity in ulcerative colitis Reviewed

    Yoichiro Iboshi, Kazuhiko Nakamura, Keita Fukaura, tsutomu iwasa, Haruei Ogino, Yorinobu Sumida, Eikichi Ihara, Hirotada Akiho, Naohiko Harada, Makoto Nakamuta

    Journal of gastroenterology   52 ( 3 )   315 - 326   2017.3

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    DOI： 10.1007/s00535-016-1221-1

  • Limited effect of rebamipide in addition to proton pump inhibitor (PPI) in the treatment of post-endoscopic submucosal dissection gastric ulcers A randomized controlled trial comparing ppi plus rebamipide combination therapy with PPI monotherapy Reviewed

    Kazuhiko Nakamura, Eikichi Ihara, Hirotada Akiho, Kazuya Akahoshi, Naohiko Harada, Toshiaki Ochiai, Norimoto Nakamura, Haruei Ogino, tsutomu iwasa, Akira Aso, Yoichiro Iboshi, Ryoichi Takayanagi

    Gut and Liver   10 ( 6 )   2016.11

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    DOI： 10.5009/gnl15486

  • Promising biological therapies for ulcerative colitis: A review of the literature. International journal

    Hirotada Akiho, Azusa Yokoyama, Shuichi Abe, Yuichi Nakazono, Masatoshi Murakami, Yoshihiro Otsuka, Kyoko Fukawa, Mitsuru Esaki, Yusuke Niina, Haruei Ogino

    World journal of gastrointestinal pathophysiology   6 ( 4 )   219 - 27   2015.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.4291/wjgp.v6.i4.219

  • Characteristics of hemorrhagic peptic ulcers in patients receiving antithrombotic/nonsteroidal antiinflammatory drug therapy Reviewed

    Kazuhiko Nakamura, Kazuya Akahoshi, Toshiaki Ochiai, Keishi Komori, Kazuhiro Haraguchi, Munehiro Tanaka, Norimoto Nakamura, Yoshimasa Tanaka, Kana Kakigao, Haruei Ogino, Eikichi Ihara, Hirotada Akiho, Yasuaki Motomura, Teppei Kabemura, Naohiko Harada, Yoshiharu Chijiiwa, Tetsuhide Ito, Ryoichi Takayanagi

    Gut and Liver   6 ( 4 )   423 - 426   2012.10

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    Language：English  

    DOI： 10.5009/gnl.2012.6.4.423

  • Feeding administration of daikenchuto suppresses colitis induced by naive CD4+ T cell transfer into SCID mice Reviewed

    tsutomu iwasa, Haruei Ogino, Kazuhiko Nakamura, Eikichi Ihara, Hirotada Akiho, Ryoichi Takayanagi

    Digestive Diseases and Sciences   57 ( 10 )   2571 - 2579   2012.10

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    Language：English  

    DOI： 10.1007/s10620-012-2218-0

  • Regulatory T cells expanded by rapamycin in vitro suppress colitis in an experimental mouse model Reviewed

    OGINO Haruei, NAKAMURA Kazuhiko, IWASA Tsutomu, IHARA Eikich, AKIHO Hirotada, MOTOMURA Yasuaki, AKAHOSHI Kazuya, IGARASHI Hisato, KATO Masaki, KOTOH Kazuhiro, ITO Tetsuhide, TAKAYANAGI Ryoichi

    Journal of gastroenterology   47 ( 4 )   366 - 376   2012.4

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    Regulatory T cells expanded by rapamycin in vitro suppress colitis in an experimental mouse model
    Background: To provide rapid immunosuppression without side effects, we analyzed whether rapamycin alone, and regulatory T cells (Tregs) expanded ex vivo by rapamycin, suppressed colitis in a mouse model. Methods: Severe combined immunodeficiency (SCID) mice reconstituted with naive CD4+ T cells were treated with or without intraperitoneal rapamycin. Body weight was evaluated. CD4+ T cells were cultured inthe presence of rapamycin for three 7-day rounds of stimulation. The ratio of Tregs to CD4+T cells was analyzed by flow cytometry. NaiveCD4+T cells were transferred into SCID mice with CD4+ T cells expanded in the presence or absence of rapamycin. Clinical symptoms of colitis, histological changes, and cytokine expression were investigated. Results: Systemic rapamycin partially prevented the development of colonic inflammation in a transfer model of colitis, but decreased body weight in control mice. With rapamycin, stimulated CD4 +T cells expanded eightfold in 3 weeks in vitro, and the proportion of Tregs increased to about 40&#37;. Without rapamycin, CD4+T cells expanded 20-fold in 3 weeks, but the proportion of Tregs remained at about 15&#37;. CD4+ T cells expanded with rapamycin prevented the development of colitis in a naïve CD4+ T-cell transfer model, in association with the down regulation of Th1 and Th17 responses. Conclusions: We demonstrated, for the first time, that CD4+ T cells expanded with rapamycin in vitro suppressed colitis. Therefore, rapamycin-expanded Treg transfer therapy is expected to be efficacious for inflammatory bowel disease.

    DOI： 10.1007/s00535-011-0502-y

  • Hepatopancreatobiliary manifestations of inflammatory bowel disease Reviewed

    Kazuhiko Nakamura, Tetsuhide Ito, Kazuhiro Kotoh, Eikichi Ihara, Haruei Ogino, Tsutomu Iwasa, Yoshimasa Tanaka, Yoichiro Iboshi, Ryoichi Takayanagi

    Clinical Journal of Gastroenterology   5 ( 1 )   1 - 8   2012.2

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    Language：English  

    DOI： 10.1007/s12328-011-0282-1

  • Th1 responses are more susceptible to infliximab-mediated immunosuppression than Th17 responses Reviewed

    Kenji Kanayama, Kazuhiko Nakamura, Haruei Ogino, Yorinobu Sumida, Eikichi Ihara, Hirotada Akiho, Ryoichi Takayanagi

    Digestive Diseases and Sciences   56 ( 12 )   3525 - 3533   2011.12

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    Language：English  

    DOI： 10.1007/s10620-011-1780-1

  • Endoscopic ultrasound-guided transmural drainage of inflammatory peripancreatic fluid collections with a wire-guided triple-lumen needle knife Reviewed

    Soichi Itaba, Yorinobu Sumida, Akira Aso, Yoichiro Iboshi, Tsutomu Iwasa, Haruei Ogino, Hisato Igarashi, Hirotada Akiho, Kazuhiko Nakamura, Tetsuhide Ito, Ryoichi Takayanagi

    Digestive Endoscopy   23 ( 3 )   269   2011.7

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    Language：English  

    DOI： 10.1111/j.1443-1661.2010.01089.x

  • CD4(+)CD25(+) regulatory T cells suppress Th17-responses in an experimental colitis model Reviewed

    OGINO H

    Dig Dis Sci   56 ( 2 )   376 - 386   2011.2

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    CD4+CD25+ regulatory T cells suppress Th17-responses in an experimental colitis model
    Background: After the recent discovery of Th17 cells, it was proposed that Th17 responses are involved in the pathogenesis of inflammatory bowel diseases (IBD). CD4+CD25+ regulatory T cells (Treg) are considered to be an attractive tool for the treatment of IBD. Here, we investigated whether Treg are capable of suppressing Th17-mediated colitis. Methods: Naive CD4 + T cells were transferred into SCID mice with or without Treg. In some experiments, Treg were transferred into recipient mice with established colitis. Mice treated with Treg were injected with an anti-transforming growth factor (TGF)-β mAb or control IgG. Clinical symptoms of colitis, histological changes and cytokine expressions were investigated. Results: SCID mice transferred with naive CD4+ T cells developed chronic colitis with significant increases in Th1 and Th17 cytokine expressions in the colon. When Treg were co-transferred with naive CD4+ T cells, development of colitis was prevented, and Th17 cytokine expressions were markedly reduced. Similarly, when Treg were transferred into mice with established colitis, the colitis was significantly ameliorated in association with dramatic reductions in Th17 cytokine expressions. Injection of anti-TGF-β mAb abolished the Treg-mediated suppression with significant elevations in Th17 cytokine productions. Conclusion: This adoptive transfer model of colitis was associated with augmented Th1 and Th17 responses, and Treg were capable of suppressing colonic inflammation by downregulating Th17 responses as well as Th1 responses via TGF-β. Consequently, Treg transfer therapy is expected to be efficacious for IBD even if Th17 is involved in the pathogenesis.

    DOI： 10.1007/s10620-010-1286-2

  • LOW-FREQUENCY OF BACTEREMIA AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION OF THE STOMACH Reviewed

    ITABA SOICHI, IBOSHI YOICHIRO, NAKAMURA KAZUHIKO, OGINO HARUEI, SUMIDA YORINOBU, ASO AKIRA, YOSHINAGA SHIGETAKA, AKIHO HIROTADA, IGARASHI HISATO, KATO MASAKI, KOTOH KAZUHIRO, ITO TETSUHIDE, TAKAYANAGI RYOICHI

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   23 ( 1 )   69 - 72   2011.1

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    Low-frequency of bacteremia after endoscopic submucosal dissection of the stomach.
    Mainstream therapy for early gastric cancer in Japan has now shifted from endoscopic mucosal resection (EMR) to endoscopic submucosal dissection (ESD). Although bacteremia is reported as being infrequent and transient in gastric EMR, there are no reports of it being investigated in gastric ESD. This study aimed to determine the frequency of bacteremia in gastric ESD. A prospective study, in 46 consecutive patients who underwent gastric ESD, investigated the frequency of bacteremia before and after the procedure. Results: The median time for the total ESD procedure was 105min (range 30-400). The median volume of the submucosal injection was 80ml (range 20-260). The mean size of the resected specimen was 40±9.7mm. Blood cultures obtained before ESD were positive in 4.4&#37; (2/45) of cases. Bacillus subtilis and Bacillus spp. were the isolated microorganisms. Blood cultures obtained 10min after ESD were positive in 4.3&#37; (2/46) of cases; with the same microorganisms being isolated. Blood cultures obtained 3h after ESD were all negative. No signs of sepsis were seen in the two patients with a positive blood culture 10min after ESD. The frequency of bacteremia after gastric ESD was low and transient. ESD for gastric lesions is thought to have a low risk of infectious complications; therefore, prophylactic administration of antibiotics may not be warranted.

    DOI： 10.1111/j.1443-1661.2010.01066.x

  • Reply to Hagiwara Reviewed

    T. Iwasa, K. Nakamura, Haruei Ogino, Y. Iboshi, A. Aso, Eikichi Ihara, R. Takayanagi

    Endoscopy   43 ( 10 )   2011.1

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    DOI： 10.1055/s-0030-1256699

  • Multiple ulcers in the small and large intestines occurred during tocilizumab therapy for rheumatoid arthritis Reviewed

    T. Iwasa, K. Nakamura, Haruei Ogino, S. Itaba, H. Akiho, R. Okamoto, Y. Iboshi, A. Aso, H. Murao, K. Kanayama, T. Ito, R. Takayanagi

    Endoscopy   43 ( 1 )   70 - 72   2011

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1055/s-0030-1255931

  • Persistent gut motor dysfunction in a murine model of T-cell-induced enteropathy Reviewed

    T. Mizutani, H. Akiho, W. I. Khan, H. Murao, Haruei Ogino, K. Kanayama, K. Nakamura, R. Takayanagi

    Neurogastroenterology and Motility   22 ( 2 )   2010.2

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    DOI： 10.1111/j.1365-2982.2009.01396.x

  • Impact of double-balloon endoscopy on the diagnosis of jejuoileal involvement in primary intestinal follicular lymphomas : a case series Reviewed

    HIGUCHI N

    Endoscopy   41 ( 2 )   175 - 178   2009.2

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    Impact of double-balloon endoscopy on the diagnosis of jejunoileal involvement in primary intestinal follicular lymphomas A case series
    In recent years, primary gastrointestinal follicular lymphoma has been increasingly detected in the duodenum on esophagogastroduodenoscopy (EGD). Primary gastrointestinal follicular lymphomas are frequently distributed to multiple sites in the gastrointestinal tract. Therefore, investigation into the spread of follicular lymphomas in the small bowel is important in order to determine the most appropriate treatment strategy. The performance of double-balloon endoscopy (DBE) in the diagnosis of jejunoileal follicular lymphoma lesions has not been fully evaluated. We aimed to investigate the value of DBE in addition to computed tomography (CT) and 18F- fluorodeoxyglucose positron emission tomography (18F-FDG-PET) in the diagnosis of jejunoileal follicular lymphoma. DBE with biopsy was performed in seven patients with primary duodenal follicular lymphoma diagnosed by EGD, in order to investigate jejunoileal involvement. Jejunoileal follicular lymphoma lesions were detected by DBE in six out of the seven patients (three in the jejunum and three in the jejunum and ileum), whereas CT and 18F-FDG- PET failed to detect the existence of these lesions. Endoscopic findings of the jejunoileal lesions revealed multiple white nodules and white villi, which were similar to those of duodenal lesions. DBE was more useful for the diagnosis of jejunoileal involvement in primary intestinal follicular lymphoma than CT and 18F-FDG-PET. The use of DBE will become important for determining the most appropriate treatment for gastrointestinal follicular lymphoma.

    DOI： 10.1055/s-0028-1119467

  • Duplication cyst of the small intestine found by double-balloon endoscopy A case report Reviewed

    Haruei Ogino, Toshiaki Ochiai, Norimoto Nakamura, Daisuke Yoshimura, Teppei Kabemura, Tetsuya Kusumoto, Hiroshi Matsuura, Akihiko Nakashima, Kuniomi Honda, Kazuhiko Nakamura

    World Journal of Gastroenterology   14 ( 24 )   3924 - 3926   2008.10

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    Language：English  

    DOI： 10.3748/wjg.14.3924

  • Gastric emptying in diabetic patients by the 13 C-octanoic acid breath test Role of insulin in gastric motility Reviewed

    Masahiro Matsumoto, Rie Yoshimura, Hirotada Akiho, Naomi Higuchi, Kunihisa Kobayashi, Noriaki Matsui, Kentaro Taki, Hiroyuki Murao, Haruei Ogino, Kenji Kanayama, Yorinobu Sumida, Takahiro Mizutani, Kuniomi Honda, Shigetaka Yoshinaga, Soichi Itaba, Hiromi Muta, Naohiko Harada, Kazuhiko Nakamura, Ryoichi Takayanagi

    Journal of gastroenterology   42 ( 6 )   469 - 474   2007.6

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    Language：English  

    DOI： 10.1007/s00535-007-2031-2

  • An esophageal ulcer mimicking advanced esophageal cancer in a patient on alendronate sodium treatment for osteoporosis. Reviewed

    T. Terashima, K. Hiramatsu, A. Shimatani, M. Matsuda, Haruei Ogino, Y. Satomura, Y. Noda

    Endoscopy   38 Suppl 2   2006.1

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    Language：English  

    DOI： 10.1055/s-2006-944671

  • A case of advanced gastric cancer effectively treated by TS-1 for 4 years Reviewed

    Haruei Ogino, Tadashi Misawa, Toshifumi Nasu, Yuuji Ihara, Shigeru Kubo, Yojiro Sadamoto, Naohiko Harada, Kazuhiko Nakamura

    Gan to kagaku ryoho. Cancer & chemotherapy   32 ( 6 )   833 - 836   2005.1

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  • A case of the passage of a stripped colonic mucosa Reviewed

    Haruei Ogino, Shigeru Kubo, Tadashi Misawa, Toshifumi Nasu, Yuuji Ihara, Yojiro Sasamoto, Naohiko Harada

    Gastroenterological Endoscopy   47 ( 1 )   22 - 27   2005.1

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    Language：English  

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Presentations

  • 診療報酬明細データベースにおける潰瘍性大腸炎抽出アルゴリズムの妥当性の検証

    荻野治栄、森久保拓、深浦啓太、奥井佑、Sean Gardiner 、杉山直伸 、吉井規敏、Haoqian Chen、Soko Setoguchi、中島直樹、小林拓

    2019.11 

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    Event date： 2019.11

    Language：Japanese  

    Venue：福岡市   Country：Japan  

  • Is the histological inflammation a predictor of future relapse in quiescent　Ulcerative colitis?

    ＠Haruei Ogino, @Keita Fukaura, @Yuichiro Nishihara

    2019.5 

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    Event date： 2019.5 - 2019.6

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：新高輪ホテル   Country：Japan  

MISC

  • USEFULNESS OF ONIGIRI ESOPHAGOGRAPHY COMBINED WITH AN OBSTRUCTION LEVEL CLASSIFICATION SYSTEM IN SCREENING ESOPHAGEAL MOTILITY DISORDERS

    Eikichi Ihara, Shohei Hamada, Kazumasa Muta, Masafumi Wada, Yoshitaka Hata, Hiroko Ikeda, Yoshimasa Tanaka, Haruei Ogino, Takatoshi Chinen, Yoshihiro Ogawa

    GASTROENTEROLOGY   2021.5

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    Language：English  

  • TRANSCRIPTOME ANALYSIS REVEALS THAT MICROBIOTA IN THE INTESTINAL MUCOSAL IS RELATED WITH THE SEVERITY AND CLINICAL COURSE OF ULCERATIVE COLITIS

    Yuichiro Nishihara, Haruei Ogino, Masaru Tanaka, Eikichi Ihara, Takatoshi Chinen, Kei Nishioka, Hiroko Ikeda, Yasuyo Hayashi, Hiroaki Okuno, Keita Fukaura, Jiro Nakayama, Hirotada Akiho, Yoshihiro Ogawa

    GASTROENTEROLOGY   2020.5

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    Language：English  

  • USEFULNESS OF BARIUM ESOPHAGRAM WITH NEWLY DEVELOPED WAVE APPEARANCE IN SCREENING TOOL FOR ESOPHAGEAL MOTILITY DISORDERS

    Yoshitaka Hata, Shohei Hamada, Masafumi Wada, Hiroko Ikeda, Keishi Komori, Haruei Ogino, Eikichi Ihara, Hirotada Akiho, Yoshihiro Ogawa

    GASTROENTEROLOGY   2020.5

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  • ELEVATION OF BASAL EGJ PRESSURE IS ASSOCIATED WITH LOW-EFFICACY OF ACOTIAMIDE FOR THE PATIENTS WITH EGJ OUTFLOW OBSTRUCTION

    Eikichi Ihara, Kazumasa Muta, Xiaopeng Bai, Shohei Hamada, Hiroko Ikeda, Keishi Komori, Haruei Ogino, Takatoshi Chinen, Yoshihiro Ogawa

    GASTROENTEROLOGY   2019.5

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  • SIGNIFICANT DIFFERENCE IN THE PROPORTION OF UNDERLYING DISEASES BETWEEN CONVENTIONAL PROTON PUMP INHIBITORS AND VONOPRAZAN REFRACTORY GASTROESOPHAGEAL REFLUX DISEASE.

    Shohei Hamada, Eikichi Ihara, Kazumasa Muta, Hiroko Ikeda, Kouzi Mukai, Yoshihiro Otsuka, Yoshitaka Hata, Haruei Ogino, Takatoshi Chinen, Yoshihiro Ogawa

    GASTROENTEROLOGY   2019.5

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  • IMPAIRED ESOPHAGOGASTRIC JUNCTION RECESSIVE RELAXATION PLAYS A CENTRAL ROLE IN ESOPHAGEAL MOTILITY DISORDERS ASSOCIATED WITH SYSTEMIC SCLERODERMA

    Hiroko Ikeda, Eikichi Ihara, Shohei Hamada, Kazumasa Muta, Keita Fukaura, Yoshihiro Otsuka, Yoshitaka Hata, Koji Mukai, Keishi Komori, Haruei Ogino, Takatoshi Chinen, Yoshihiro Ogawa

    GASTROENTEROLOGY   2019.5

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  • EXPRESSION PROFILES OF HELPER T-CELL-RELATED GENES IN THE INTESTINAL MUCOSA MAY PREDICT THE EFFECT OF ANTI-TUMOR NECROSIS FACTOR-ALPHA ANTIBODY AGENTS IN ULCERATIVE COLITIS PATIENTS

    Kei Nishioka, Keita Fukaura, Hiroaki Okuno, Yuichiro Nishihara, Haruei Ogino, Takatoshi Chinen, Eikichi Ihara, Yoshihiro Ogawa

    GASTROENTEROLOGY   2019.5

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  • CLINICAL OUTCOME OF ENDOSCOPIC SUBMUCOSAL DISSECTION FOR EARLY GASTRIC CANCER IN A POST-OPERATIVE STOMACH

    Hirotada Akiho, Mitsuru Esaki, Haruei Ogino, Taizo Hosokawa, Takahiro Mizutani, Eikichi Ihara

    GASTROINTESTINAL ENDOSCOPY   2018.6

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  • ENDOSCOPIC ULTRASOUND-GUIDED FINE NEEDLE ASPIRATION VS. A MUCOSAL INCISION-ASSISTED BIOPSY FOR GASTRIC SUBMUCOSAL TUMORS: A RANDOMIZED COMPARATIVE STUDY

    Yosuke Minoda, Takashi Osoegawa, Soichi Itaba, Aso Akira, Tsutomu Iwasa, Haruei Ogino, Naohiko Harada, Eikichi Ihara, Kazuhiko Nakamura, Yoshihiro Ogawa

    GASTROINTESTINAL ENDOSCOPY   2018.6

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  • COMPARISON BETWEEN CLUTCH CUTTER AND OTHER DEVICES IN THE TECHNICAL OUTCOMES IN ENDOSCOPIC SUBMUCOSAL DISSECTION FOR EARLY GASTRIC CANCER

    Yasuyo Hayashi, Mitsuru Esaki, Taizo Hosokawa, Yoshimasa Tanaka, Haruei Ogino, Takahiro Mizutani, Eikichi Ihara, Hirotada Akiho

    GASTROINTESTINAL ENDOSCOPY   2018.6

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  • BOTH INCOMPLETE LES RELAXATION AND PREMATURE CONTRACTION OF ESOPHAGEAL BODY ARE CHARACTERISTICS OF DRY SWALLOW

    Kazumasa Muta, Eikichi Ihara, Keita Fukaura, Xiaopeng Bai, Yoshitaka Hata, Haruei Ogino, Toshiaki Ochiai, Kazuhiko Nakamura, Yoshihiro Ogawa

    GASTROENTEROLOGY   2018.5

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  • THE ESOPHAGEAL INTRALUMINAL BASELINE IMPEDANCE DIFFERENTIATES REFLUX HYPERSENSITIVITY FROM NERD

    Shohei Hamada, Eikichi Ihara, Kazumasa Muta, Keita Fukaura, Haruei Ogino, Xiaopeng Bai, Koji Mukai, Yoshihiro Otsuka, Keishi Komori, Yoshitaka Hata, Akira Aso, Tsutomu Iwasa, Toshiaki Ochiai, Hirotada Akiho, Kazuhiko Nakamura, Yoshihiro Ogawa

    GASTROENTEROLOGY   2018.5

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  • NICOTINE CAUSED THE DUAL REGULATION OF TONE IN THE PORCINE LOWER ESOPHAGEAL SPHINCTER THROUGH EXCITATORY AND INHIBITORY ENTERIC INNERVATION

    Xiaopeng Bai, Eikichi Ihara, Yoshihiro Otsuka, Haruei Ogino, Hirotada Akiho, Kazuhiko Nakamura, Yoshihiro Ogawa

    GASTROENTEROLOGY   2018.5

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  • Clinical outcome of endoscopic submucosal dissection for early gastric cancer in a post-operative stomach: A single-center experience

    Mitsuru Esaki, Kaori Hayashi, Sho Suzuki, Chika Kusano, Shuichi Itonaga, Yasuyo Hayashi, Azusa Yokoyama, Shuichi Abe, Taizo Hosokawa, Haruei Ogino, Hirotada Akiho, Takuji Gotoda

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   2017.9

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  • Safety Advantage of the New Device (Splash-M Knifea (R)) for Endoscopic Submucosal Dissection of Early Gastric Neoplasms

    Mitsuru Esaki, Hirotada Akiho, Haruei Ogino, Taizo Hosokawa, Yusuke Niina, Eikichi Ihara, Kazuhiko Nakamura

    GASTROINTESTINAL ENDOSCOPY   2017.5

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    Language：English  

    DOI： 10.1016/j.gie.2017.03.1167

  • Mucosal IL-13 Expression Correlates with Disease Activity Portion That Is Unexplained by Th17-Related Gene Signature in a Subset of Ulcerative Colitis Patients

    Yoichiro Iboshi, Kazuhiko Nakamura, Keita Fukaura, Tsutomu Iwasa, Haruei Ogino, Yorinobu Sumida, Eikichi Ihara, Hirotada Akiho, Naohiko Harada, Makoto Nakamuta

    AMERICAN JOURNAL OF GASTROENTEROLOGY   2016.10

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    Language：English  

    DOI： 10.14309/00000434-201610001-00685

  • Daikenchuto (DKT), a Japanese Traditional Herbal Medicine Ameliorated Gastrointestinal Hypermotility by Downregulated the Interleukin-17A in a Murine Functional Gastrointestinal Disorder Model

    Hirotada Akiho, Haruei Ogino, Mitsuru Esaki, Eikichi Ihara, Kazuhiko Nakamura, Masahiro Yamamoto

    GASTROENTEROLOGY   2016.4

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    Language：English  

    DOI： 10.1016/S0016-5085(16)33059-1

  • Key Mucosal Helper T Cell-Related Gene Signature Paralleling Disease Activity in Ulcerative Colitis Is Underlain by Different Interactions Between IL-17A and IL-17F With Other Helper T Cell-Related Genes

    Yoichiro Iboshi, Kazuhiko Nakamura, Keita Fukaura, Tsutomu Iwasa, Haruei Ogino, Yorinobu Sumida, Eikichi Ihara, Hirotada Akiho, Naohiko Harada, Makoto Nakamuta

    AMERICAN JOURNAL OF GASTROENTEROLOGY   2015.10

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    Language：English  

    DOI： 10.14309/00000434-201510001-01890

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Professional Memberships

  • 日本内科学会

  • 日本消化器病学会

  • 日本消化器内視鏡学会

  • 日本消化管学会

Academic Activities

  • core session 発表

    第97回　日本内視鏡学会総会  （ 東京　品川 ） 2019.5 - 2019.6

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    Type：Competition, symposium, etc. 

Research Projects

  • 直腸環境の特殊性に着眼した潰瘍性大腸炎再燃機序の解明

    Grant number：23K07355  2023 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 直腸環境の特殊性に着眼した潰瘍性大腸炎再燃機序の解明

    Grant number：23K07355  2023 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type：Scientific research funding

  • 直腸環境の特殊性からみる潰瘍性大腸炎の再燃機序

    Grant number：20K08389  2020 - 2022

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

Class subject

  • 消化管・腹膜

    2021.10 - 2022.3   Second semester

  • 消化管・腹膜

    2019.10 - 2020.3   Second semester

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Gastroenterology

Clinician qualification

  • Preceptor

    The Japanese Society of Gastroenterology（JSGE）

  • Preceptor

    日本内科学会、　日本消化器内視鏡病学会、　日本臨床腫瘍学会、　日本炎症性腸疾患学会

Year of medical license acquisition

  • 2001

Notable Clinical Activities

  • 炎症性腸疾患の患者様の中には、治療抵抗性で難治の方や重症・劇症など重篤な方がいます。このような多くの患者さんを関連病院の先生からご紹介いただき治療にあたっている。もちろん、中には内科治療だけでは限界がある方もいるため、外科の先生と協力し適切な治療を提供できるように心がけている。また、消化管腫瘍（早期癌を含む）に対しても多くの関連病院の先生からご紹介いただき、内視鏡治療の適応がある場合には、非侵襲的な内視鏡治療である内視鏡的粘膜下層剥離術も積極的に行っている。