Updated on 2025/04/10

Information

 

写真a

 
YOKOYAMA NOBUHIKO
 
Organization
Kyushu University Hospital Orthopedic Surgery Assistant Professor
Title
Assistant Professor
Contact information
メールアドレス
Tel
0926425488
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Degree

  • なし

Research Interests・Research Keywords

  • Research theme: Elucidation of Drug Resistance Mechanisms in Soft Tissue Sarcomas

    Keyword: Soft Tissue Sarcoma, Drug Resistance

    Research period: 2024.4

Papers

  • Secondary Peripheral Dedifferentiated Chondrosarcoma: A Case Report with Special Emphasis on the Radiology/Pathology Correlation. International journal

    Masato Yoshimoto, Nokitaka Setsu, Nobuhiko Yokoyama, Kenichi Taguchi, Kenichi Kohashi, Yoshinao Oda

    JBJS case connector   13 ( 2 )   2023.4

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    CASE: In a 54-year-old man, imaging findings suggested a malignant bone tumor having 2 distinct components of the left ilium. Histopathologically, the resected tumor was diagnosed as dedifferentiated chondrosarcoma (CS) arising in secondary peripheral CS. CONCLUSION: Dedifferentiated CS consists of a high-grade noncartilaginous sarcoma adjacent to a preexisting low-grade CS, among which the peripheral type is extremely rare. Because the bimorphic imaging findings reflected the dedifferentiated area and the CS area, they were considered useful for diagnosis. In addition, the dedifferentiated area was localized to the tumor's edge, suggesting that the dedifferentiation originated from the cartilage cap.

  • Effect of low body mass index on clinical recovery after fusion surgery for osteoporotic vertebral fracture: A retrospective, multicenter study of 237 cases. International journal

    Gen Inoue, Masayuki Miyagi, Wataru Saito, Eiki Shirasawa, Kentaro Uchida, Naobumi Hosogane, Kei Watanabe, Keiichi Katsumi, Takashi Kaito, Tomoya Yamashita, Hiroyasu Fujiwara, Yukitaka Nagamoto, Kenya Nojiri, Satoshi Suzuki, Eijiro Okada, Seiji Ueda, Tomohiro Hikata, Yuta Shiono, Kota Watanabe, Hidetomi Terai, Koji Tamai, Yuji Matsuoka, Hidekazu Suzuki, Hirosuke Nishimura, Atsushi Tagami, Shuta Yamada, Shinji Adachi, Seiji Ohtori, Takeo Furuya, Sumihisa Orita, Kazuhide Inage, Toshitaka Yoshii, Shuta Ushio, Haruki Funao, Norihiro Isogai, Katsumi Harimaya, Seiji Okada, Kenichi Kawaguchi, Nobuhiko Yokoyama, Hidekazu Oishi, Toshio Doi, Katsuhito Kiyasu, Shiro Imagama, Kei Ando, Kazuyoshi Kobayashi, Daisuke Sakai, Masahiro Tanaka, Atsushi Kimura, Hirokazu Inoue, Atsushi Nakano, Shota Ikegami, Masayuki Shimizu, Toshimasa Futatsugi, Kenichiro Kakutani, Takashi Yurube, Kazuyoshi Nakanishi, Masashi Oshima, Hiroshi Uei, Yasuchika Aoki, Masahiko Takahata, Akira Iwata, Hirooki Endo, Shoji Seki, Hideki Murakami, Satoshi Kato, Katsuhito Yoshioka, Michio Hongo, Tetsuya Abe, Toshinori Tsukanishi, Masashi Takaso, Ken Ishii

    Medicine   101 ( 52 )   e32330   2022.12

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    A retrospective multicenter study. Body mass index (BMI) is recognized as an important determinant of osteoporosis and spinal postoperative outcomes; however, the specific impact of BMI on surgery for osteoporotic vertebral fractures (OVFs) remains inconclusive. This retrospective multicenter study investigated the impact of BMI on clinical outcomes following fusion surgery for OVFs. 237 OVF patients (mean age, 74.3 years; 48 men and 189 women) with neurological symptoms who underwent spinal fusion were included in this study. Patients were grouped by World Health Organization BMI categories: low BMI (<18.5 kg/m2), normal BMI (≥18.5 and <25 kg/m2), and high BMI (≥25 kg/m2). Patients' backgrounds, surgical method, radiological findings, pain measurements, activities of daily living (ADL), and postoperative complications were compared after a mean follow-up period of 4 years. As results, the proportion of patients able to walk independently was significantly smaller in the low BMI group (75.0&#37;) compared with the normal BMI group (89.9&#37;; P = .01) and the high BMI group (94.3&#37;; P = .04). Improvement in the visual analogue scale for leg pain was significantly less in the low BMI group than the high BMI group (26.7 vs 42.8 mm; P = .046). Radiological evaluation, the Frankel classification, and postoperative complications were not significantly different among all 3 groups. Improvement of pain intensity and ADL in the high BMI group was equivalent or non-significantly better for some outcome measures compared with the normal BMI group. Leg pain and independent walking ability after fusion surgery for patients with OVFs improved less in the low versus the high BMI group. Surgeons may want to carefully evaluate at risk low BMI patients before fusion surgery for OVF because poor clinical results may occur.

    DOI: 10.1097/MD.0000000000032330

  • Clinical, Radiological, and Histopathological Characteristics of Periosteal Chondrosarcoma with a Focus on the Frequency of Medullary Invasion. International journal

    Makoto Nakagawa, Makoto Endo, Yosuke Susuki, Nobuhiko Yokoyama, Akira Maekawa, Akira Nabeshima, Keiichiro Iida, Toshifumi Fujiwara, Nokitaka Setsu, Tomoya Matsunobu, Yoshihiro Matsumoto, Ryohei Yokoyama, Yuichi Yamada, Kenichi Kohashi, Hidetaka Yamamoto, Yoshinao Oda, Yukihide Iwamoto, Yasuharu Nakashima

    Journal of clinical medicine   11 ( 7 )   2022.4

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    Periosteal chondrosarcoma is an extremely rare malignant cartilage-forming tumour that originates from the periosteum and occurs on the surface of bone. Often, it is difficult to distinguish periosteal chondrosarcoma from other tumours, and reports in the literature are scarce. This study aims to investigate the characteristics of periosteal chondrosarcoma, focusing particularly on medullary invasion. Among 33 periosteal cartilaginous tumours, seven patients with pathologically proven periosteal chondrosarcoma were identified retrospectively. The average tumour size was 5.4 cm in the long axis; two tumours were smaller than 3.0 cm. Six tumours were resected with a wide margin, and the remaining tumour had a marginal margin. Histology revealed that six tumours (85.7&#37;) had invaded the medullary cavity; three of these did not show invasion into the medullary cavity on MRI evaluation. Neither local recurrence nor metastasis was observed among these patients. The frequency of invasion of the medullary cavity was higher than that reported previously. The recommended treatment for periosteal chondrosarcoma is resection with an adequate margin. Therefore, surgeons should consider the possibility of medullary invasion when attempting to achieve a histologically negative margin, even if the tumour does not show invasion into the medullary cavity on MRI.

    DOI: 10.3390/jcm11072062

  • 頭部皮下に転移した左脛骨骨肉腫の1例

    吉本 昌人, 横山 良平, 横山 信彦

    整形外科と災害外科   70 ( 4 )   782 - 785   2021.9

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    【目的】長期経過後,頭部皮下に転移した骨肉腫症例を経験したため報告する.【症例】36歳,女性.25歳時に誘因なく左膝痛が出現し,近医で左脛骨近位端に骨腫瘍を指摘され,当院紹介受診した.通常型骨肉腫の診断となり,術前後化学療法,腫瘍広範切除及び腫瘍用人工関節置換術を施行した.術後10年,側胸部痛を主訴に来院し,胸部単純CT検査で右第10肋骨と右肺に転移性腫瘍を認め,PET-CT検査では後頭部皮下に6mm大の異常集積を認めた.頭部皮下腫瘤に対して切除生検行い,病理診断は骨肉腫転移であった.【考察】骨肉腫の頭部皮下転移は非常に稀であり,文献的考察を含めて報告する.(著者抄録)

  • 深層発生脂肪腫と異型脂肪腫様腫瘍の鑑別における炎症性マーカーの有用性

    横山 信彦, 横山 良平, 吉本 昌人

    整形外科と災害外科   70 ( 4 )   754 - 757   2021.9

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    【背景】時に筋肉内脂肪腫などの深層発生脂肪腫(DSL)と異型脂肪腫様腫瘍(ALT)は画像による鑑別が困難な症例に遭遇する.近年様々な癌腫の予後予測因子として報告されている血液検査の好中球/リンパ球比(NLR)や血小板/リンパ球比(PLR)が軟部腫瘍の良悪性鑑別に有用とする報告もあり,脂肪性腫瘍の鑑別に適応できるか検討した.【対象と方法】2001年7月から2020年3月に当科にて初回手術を行った16歳以上の四肢・体幹壁のDSLおよびALT 58例を対象とし,MRIでの腫瘍最大径,術前NLR,術前PLRを評価項目として,DSLとALTについて検討した.【結果】DSL 38例,ALT 20例で,腫瘍最大径はDSL群で9.4±5.1cm,ALT群で19.5±5.8cm,NLR・PLRはそれぞれDSL群で1.74±0.68,124.5±48.0,ALT群で2.29±1.32,170.0±81.4と,いずれもDSL群で有意に低かった.【結論】NLR・PLRはDSLとALT間で有意差を認めた.(著者抄録)

  • 狭心症様の左前胸部痛で発症した胸椎転移の1例

    松尾 拓, 横山 良平, 横山 信彦

    整形外科と災害外科   69 ( 4 )   825 - 826   2020.9

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    【はじめに】狭心症様の左前胸部痛が初発症状であった胸椎転移の1例を経験したので報告する.【症例】患者は76歳男性で去勢抵抗性前立腺癌加療中による右大腿骨近位部骨転移の病的骨折に対して,右大腿骨近位部置換術を施行した.術後8日目の夜間及び朝方に15分程度の前胸部痛を生じた.心電図・心エコーでは明らかな器質的疾患を認めなかったが,その後も頻回に症状があり,冠攣縮性狭心症の診断で内服薬治療を開始した.しかし改善がなく胸椎転移の可能性を念頭に診察を行うと背部に叩打痛があった.MRIにてTh5の棘突起の転移があり脊髄圧迫を伴っていた.第5胸椎に対して放射線治療を行ったところ,胸痛症状は改善した.【考察】狭心症様の前胸部痛を呈する患者では虚血性心疾患以外にも胸椎疾患の可能性に留意することが望まれる.(著者抄録)

  • Short- versus long-segment posterior spinal fusion with vertebroplasty for osteoporotic vertebral collapse with neurological impairment in thoracolumbar spine: a multicenter study. International journal

    Yuya Ishikawa, Kei Watanabe, Keiichi Katsumi, Masayuki Ohashi, Yohei Shibuya, Tomohiro Izumi, Toru Hirano, Naoto Endo, Takashi Kaito, Tomoya Yamashita, Hiroyasu Fujiwara, Yukitaka Nagamoto, Yuji Matsuoka, Hidekazu Suzuki, Hirosuke Nishimura, Hidetomi Terai, Koji Tamai, Atsushi Tagami, Shuta Yamada, Shinji Adachi, Toshitaka Yoshii, Shuta Ushio, Katsumi Harimaya, Kenichi Kawaguchi, Nobuhiko Yokoyama, Hidekazu Oishi, Toshiro Doi, Atsushi Kimura, Hirokazu Inoue, Gen Inoue, Masayuki Miyagi, Wataru Saito, Atsushi Nakano, Daisuke Sakai, Tadashi Nukaga, Shota Ikegami, Masayuki Shimizu, Toshimasa Futatsugi, Seiji Ohtori, Takeo Furuya, Sumihisa Orita, Shiro Imagama, Kei Ando, Kazuyoshi Kobayashi, Katsuhito Kiyasu, Hideki Murakami, Katsuhito Yoshioka, Shoji Seki, Michio Hongo, Kenichiro Kakutani, Takashi Yurube, Yasuchika Aoki, Masashi Oshima, Masahiko Takahata, Akira Iwata, Hirooki Endo, Tetsuya Abe, Toshinori Tsukanishi, Kazuyoshi Nakanishi, Kota Watanabe, Tomohiro Hikata, Satoshi Suzuki, Norihiro Isogai, Eijiro Okada, Haruki Funao, Seiji Ueda, Yuta Shiono, Kenya Nojiri, Naobumi Hosogane, Ken Ishii

    BMC musculoskeletal disorders   21 ( 1 )   513 - 513   2020.8

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    BACKGROUND: Vertebroplasty with posterior spinal fusion (VP + PSF) is one of the most widely accepted surgical techniques for treating osteoporotic vertebral collapse (OVC). Nevertheless, the effect of the extent of fusion on surgical outcomes remains to be established. This study aimed to evaluate the surgical outcomes of short- versus long-segment VP + PSF for OVC with neurological impairment in thoracolumbar spine. METHODS: We retrospectively collected data from 133 patients (median age, 77 years; 42 men and 91 women) from 27 university hospitals and their affiliated hospitals. We divided patients into two groups: a short-segment fusion group (S group) with 2- or 3-segment fusion (87 patients) and a long-segment fusion group (L group) with 4- through 6-segment fusion (46 patients). Surgical invasion, clinical outcomes, local kyphosis angle (LKA), and complications were evaluated. RESULTS: No significant differences between the two groups were observed in terms of neurological recovery, pain scale scores, and complications. Surgical time was shorter and blood loss was less in the S group, whereas LKA at the final follow-up and correction loss were superior in the L group. CONCLUSION: Although less invasiveness and validity of pain and neurological relief are secured by short-segment VP + PSF, surgeons should be cautious regarding correction loss.

    DOI: 10.1186/s12891-020-03539-0

  • Effect of bisphosphonates or teriparatide on mechanical complications after posterior instrumented fusion for osteoporotic vertebral fracture: a multi-center retrospective study. International journal

    Atsuyuki Kawabata, Toshitaka Yoshii, Takashi Hirai, Shuta Ushio, Takashi Kaito, Tomoya Yamashita, Hiroyasu Fujiwara, Yukitaka Nagamoto, Yuji Matsuoka, Hidekazu Suzuki, Hirosuke Nishimura, Hidetomi Terai, Koji Tamai, Atsushi Tagami, Syuta Yamada, Shinji Adachi, Kei Watanabe, Keiichi Katsumi, Masayuki Ohashi, Yohei Shibuya, Katsumi Harimaya, Kenichi Kawaguchi, Nobuhiko Yokoyama, Hidekazu Oishi, Toshiro Doi, Atsushi Kimura, Hirokazu Inoue, Gen Inoue, Masayuki Miyagi, Wataru Saito, Atsushi Nakano, Daisuke Sakai, Tadashi Nukaga, Shota Ikegami, Masayuki Shimizu, Toshimasa Futatsugi, Seiji Ohtori, Takeo Furuya, Sumihisa Orita, Shiro Imagama, Kei Ando, Kazuyoshi Kobayashi, Katsuhito Kiyasu, Hideki Murakami, Katsuhito Yoshioka, Shoji Seki, Michio Hongo, Kenichiro Kakutani, Takashi Yurube, Yasuchika Aoki, Masashi Oshima, Masahiko Takahata, Akira Iwata, Hirooki Endo, Tetsuya Abe, Toshinori Tsukanishi, Kazuyoshi Nakanishi, Kota Watanabe, Tomohiro Hikata, Satoshi Suzuki, Norihiro Isogai, Eijiro Okada, Haruki Funao, Seiji Ueda, Yuta Shiono, Kenya Nojiri, Naobumi Hosogane, Ken Ishii

    BMC musculoskeletal disorders   21 ( 1 )   420 - 420   2020.7

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    BACKGROUND: The optimal treatment of osteoporosis after reconstruction surgery for osteoporotic vertebral fractures (OVF) remains unclear. In this multicentre retrospective study, we investigated the effects of typically used agents for osteoporosis, namely, bisphosphonates (BP) and teriparatide (TP), on surgical results in patients with osteoporotic vertebral fractures. METHODS: Retrospectively registered data were collected from 27 universities and affiliated hospitals in Japan. We compared the effects of BP vs TP on postoperative mechanical complication rates, implant-related reoperation rates, and clinical outcomes in patients who underwent posterior instrumented fusion for OVF. Data were analysed according to whether the osteoporosis was primary or glucocorticoid-induced. RESULTS: A total of 159 patients who underwent posterior instrumented fusion for OVF were included. The overall mechanical complication rate was significantly lower in the TP group than in the BP group (BP vs TP: 73.1&#37; vs 58.2&#37;, p = 0.045). The screw backout rate was significantly lower and the rates of new vertebral fractures and pseudoarthrosis tended to be lower in the TP group than in the BP group. However, there were no significant differences in lumbar functional scores and visual analogue scale pain scores or in implant-related reoperation rates between the two groups. The incidence of pseudoarthrosis was significantly higher in patients with glucocorticoid-induced osteoporosis (GIOP) than in those with primary osteoporosis; however, the pseudoarthrosis rate was reduced by using TP. The use of TP also tended to reduce the overall mechanical complication rate in both primary osteoporosis and GIOP. CONCLUSIONS: The overall mechanical complication rate was lower in patients who received TP than in those who received a BP postoperatively, regardless of type of osteoporosis. The incidence of pseudoarthrosis was significantly higher in patients with GIOP, but the use of TP reduced the rate of pseudoarthrosis in GIOP patients. The use of TP was effective to reduce postoperative complications for OVF patients treated with posterior fusion.

    DOI: 10.1186/s12891-020-03452-6

  • Surgical outcomes of spinal fusion for osteoporotic vertebral fracture in the thoracolumbar spine: Comprehensive evaluations of 5 typical surgical fusion techniques.

    Kei Watanabe, Keiichi Katsumi, Masayuki Ohashi, Yohei Shibuya, Toru Hirano, Naoto Endo, Takashi Kaito, Tomoya Yamashita, Hiroyasu Fujiwara, Yukitaka Nagamoto, Yuji Matsuoka, Hidekazu Suzuki, Hirosuke Nishimura, Hidetomi Terai, Koji Tamai, Atsushi Tagami, Syuta Yamada, Shinji Adachi, Toshitaka Yoshii, Shuta Ushio, Katsumi Harimaya, Kenichi Kawaguchi, Nobuhiko Yokoyama, Hidekazu Oishi, Toshiro Doi, Atsushi Kimura, Hirokazu Inoue, Gen Inoue, Masayuki Miyagi, Wataru Saito, Atsushi Nakano, Daisuke Sakai, Tadashi Nukaga, Shota Ikegami, Masayuki Shimizu, Toshimasa Futatsugi, Seiji Ohtori, Takeo Furuya, Sumihisa Orita, Shiro Imagama, Kei Ando, Kazuyoshi Kobayashi, Katsuhito Kiyasu, Hideki Murakami, Katsuhito Yoshioka, Shoji Seki, Michio Hongo, Kenichiro Kakutani, Takashi Yurube, Yasuchika Aoki, Masashi Oshima, Masahiko Takahata, Akira Iwata, Hirooki Endo, Tetsuya Abe, Toshinori Tsukanishi, Kazuyoshi Nakanishi, Kota Watanabe, Tomohiro Hikata, Satoshi Suzuki, Norihiro Isogai, Eijiro Okada, Haruki Funao, Seiji Ueda, Yuta Shiono, Kenya Nojiri, Naobumi Hosogane, Ken Ishii

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association   24 ( 6 )   1020 - 1026   2019.11

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    BACKGROUND: A consensus on the optimal surgical procedure for thoracolumbar OVF has yet to be reached due to the previous relatively small number of case series. The study was conducted to investigate surgical outcomes for osteoporotic vertebral fracture (OVF) in the thoracolumbar spine. METHODS: In total, 315 OVF patients (mean age, 74 years; 68 men and 247 women) with neurological symptoms who underwent spinal fusion with a minimum 2-year follow-up were included. The patients were divided into 5 groups by procedure: anterior spinal fusion alone (ASF group, n = 19), anterior/posterior combined fusion (APSF group, n = 27), posterior spinal fusion alone (PSF group, n = 40), PSF with 3-column osteotomy (3CO group, n = 92), and PSF with vertebroplasty (VP + PSF group, n = 137). RESULTS: Mean operation time was longer in the APSF group (p < 0.05), and intraoperative blood loss was lower in the VP + PSF group (p < 0.05). The amount of local kyphosis correction was greater in the APSF and 3CO groups (p < 0.05). Clinical outcomes were approximately equivalent among all groups. CONCLUSION: All 5 procedures resulted in acceptable neurological outcomes and functional improvement in walking ability. Moreover, they were similar with regard to complication rates, prevalence of mechanical failure related to the instrumentation, and subsequent vertebral fracture. Individual surgical techniques can be adapted to suit patient condition or severity of OVF.

    DOI: 10.1016/j.jos.2019.07.018

  • Complications after spinal fixation surgery for osteoporotic vertebral collapse with neurological deficits: Japan Association of Spine Surgeons with ambition multicenter study.

    Yusuke Sakai, Takashi Kaito, Shota Takenaka, Tomoya Yamashita, Takahiro Makino, Naobumi Hosogane, Kenya Nojiri, Satoshi Suzuki, Eijiro Okada, Kota Watanabe, Haruki Funao, Norihiro Isogai, Seiji Ueda, Tomohiro Hikata, Yuta Shiono, Kei Watanabe, Keiichi Katsumi, Hiroyasu Fujiwara, Yukitaka Nagamoto, Hidetomi Terai, Koji Tamai, Yuji Matsuoka, Hidekazu Suzuki, Hirosuke Nishimura, Atsushi Tagami, Shuta Yamada, Shinji Adachi, Seiji Ohtori, Sumihisa Orita, Takeo Furuya, Toshitaka Yoshii, Shuta Ushio, Gen Inoue, Masayuki Miyagi, Wataru Saito, Shiro Imagama, Kei Ando, Daisuke Sakai, Tadashi Nukaga, Katsuhito Kiyasu, Atsushi Kimura, Hirokazu Inoue, Atsushi Nakano, Katsumi Harimaya, Toshio Doi, Kenichi Kawaguchi, Nobuhiko Yokoyama, Hidekazu Oishi, Shota Ikegami, Toshimasa Futatsugi, Masayuki Shimizu, Kenichiro Kakutani, Takashi Yurube, Masashi Oshima, Hiroshi Uei, Yasuchika Aoki, Masahiko Takahata, Akira Iwata, Shoji Seki, Hideki Murakami, Katsuhito Yoshioka, Hirooki Endo, Michio Hongo, Kazuyoshi Nakanishi, Tetsuya Abe, Toshinori Tsukanishi, Ken Ishii

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association   24 ( 6 )   985 - 990   2019.11

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    BACKGROUND: There have been few reports on the incidence and risk factors of the complications after spinal fixation surgery for osteoporotic vertebral collapse (OVC) with neurological deficits. This study aimed to identify the incidence and risk factors of the complications after OVC surgery. METHODS: In this retrospective multicenter study, a total of 403 patients (314 women and 89 men; mean age 73.8 years) who underwent spinal fixation surgery for OVC with neurological deficits between 2005 and 2014 were enrolled. Data on patient demographics were collected, including age, sex, body mass index, smoking, steroid use, medical comorbidities, and surgical procedures. All postoperative complications that occurred within 6 weeks were recorded. Patients were classified into two groups, namely, complication group and no complication group, and risk factors for postoperative complications were investigated by univariate and multivariate analyses. RESULTS: Postoperative complications occurred in 57 patients (14.1&#37;), and the most common complication was delirium (5.7&#37;). In the univariate analysis, the complication group was found to be older (p = 0.039) and predominantly male (p = 0.049), with higher occurrence rate of liver disease (p = 0.001) and Parkinson's disease (p = 0.039) compared with the no-complication group. In the multivariate analysis, the significant independent risk factors were age (p = 0.021; odds ratio [OR] 1.051, 95&#37; confidence interval [CI] 1.007-1.097), liver disease (p < 0.001; OR 8.993, 95&#37; CI 2.882-28.065), and Parkinson's disease (p = 0.009; OR 3.636, 95&#37; CI 1.378-9.599). CONCLUSIONS: Complications after spinal fixation surgery for OVC with neurological deficits occurred in 14.1&#37;. Age, liver disease, and Parkinson's disease were demonstrated to be independent risk factors for postoperative complications.

    DOI: 10.1016/j.jos.2019.08.015

  • Selective inhibition of mutant IDH1 by DS-1001b ameliorates aberrant histone modifications and impairs tumor activity in chondrosarcoma. International journal

    Makoto Nakagawa, Fumihiko Nakatani, Hironori Matsunaga, Takahiko Seki, Makoto Endo, Yoko Ogawara, Yukino Machida, Takuo Katsumoto, Kazutsune Yamagata, Ayuna Hattori, Shuhei Fujita, Yukiko Aikawa, Takamasa Ishikawa, Tomoyoshi Soga, Akira Kawai, Hirokazu Chuman, Nobuhiko Yokoyama, Suguru Fukushima, Kenichiro Yahiro, Atsushi Kimura, Eijiro Shimada, Takeshi Hirose, Toshifumi Fujiwara, Nokitaka Setsu, Yoshihiro Matsumoto, Yukihide Iwamoto, Yasuharu Nakashima, Issay Kitabayashi

    Oncogene   38 ( 42 )   6835 - 6849   2019.10

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    Chondrosarcoma is the second most common malignant bone tumor. It is characterized by low vascularity and an abundant extracellular matrix, which confer these tumors resistance to chemotherapy and radiotherapy. There are currently no effective treatment options for relapsed or dedifferentiated chondrosarcoma, and new targeted therapies need to be identified. Isocitrate dehydrogenase (IDH) mutations, which are detected in ~50&#37; of chondrosarcoma patients, contribute to malignant transformation by catalyzing the production of 2-hydroxyglutarate (2-HG), a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Mutant IDH inhibitors are therefore potential novel anticancer drugs in IDH mutant tumors. Here, we examined the efficacy of the inhibition of mutant IDH1 as an antitumor approach in chondrosarcoma cells in vitro and in vivo, and investigated the association between the IDH mutation and chondrosarcoma cells. DS-1001b, a novel, orally bioavailable, selective mutant IDH1 inhibitor, impaired the proliferation of chondrosarcoma cells with IDH1 mutations in vitro and in vivo, and decreased 2-HG levels. RNA-seq analysis showed that inhibition of mutant IDH1 promoted chondrocyte differentiation in the conventional chondrosarcoma L835 cell line and caused cell cycle arrest in the dedifferentiated JJ012 cell line. Mutant IDH1-mediated modulation of SOX9 and CDKN1C expression regulated chondrosarcoma tumor progression, and DS-1001b upregulated the expression of these genes via a common mechanism involving the demethylation of H3K9me3. DS-1001b treatment reversed the epigenetic changes caused by aberrant histone modifications. The present data strongly suggest that inhibition of mutant IDH1 is a promising therapeutic approach in chondrosarcoma, particularly for the treatment of relapsed or dedifferentiated chondrosarcoma.

    DOI: 10.1038/s41388-019-0929-9

  • Risk Factors for Proximal Junctional Fracture Following Fusion Surgery for Osteoporotic Vertebral Collapse with Delayed Neurological Deficits: A Retrospective Cohort Study of 403 Patients.

    Koji Tamai, Hidetomi Terai, Akinobu Suzuki, Hiroaki Nakamura, Kei Watanabe, Keiichi Katsumi, Masayuki Ohashi, Yohei Shibuya, Tomohiro Izumi, Toru Hirano, Takashi Kaito, Tomoya Yamashita, Hiroyasu Fujiwara, Yukitaka Nagamoto, Yuji Matsuoka, Hidekazu Suzuki, Hirosuke Nishimura, Atsushi Tagami, Syuta Yamada, Shinji Adachi, Toshitaka Yoshii, Shuta Ushio, Katsumi Harimaya, Kenichi Kawaguchi, Nobuhiko Yokoyama, Hidekazu Oishi, Toshiro Doi, Atsushi Kimura, Hirokazu Inoue, Gen Inoue, Masayuki Miyagi, Wataru Saito, Atsushi Nakano, Daisuke Sakai, Tadashi Nukaga, Shota Ikegami, Masayuki Shimizu, Toshimasa Futatsugi, Seiji Ohtori, Takeo Furuya, Sumihisa Orita, Shiro Imagama, Kei Ando, Kazuyoshi Kobayashi, Katsuhito Kiyasu, Hideki Murakami, Katsuhito Yoshioka, Shoji Seki, Michio Hongo, Kenichiro Kakutani, Takashi Yurube, Yasuchika Aoki, Masashi Oshima, Masahiko Takahata, Akira Iwata, Hirooki Endo, Tetsuya Abe, Toshinori Tsukanishi, Kazuyoshi Nakanishi, Kota Watanabe, Tomohiro Hikata, Satoshi Suzuki, Norihiro Isogai, Eijiro Okada, Haruki Funao, Seiji Ueda, Yuta Shiono, Kenya Nojiri, Naobumi Hosogane, Ken Ishii

    Spine surgery and related research   3 ( 2 )   171 - 177   2019.4

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    INTRODUCTION: Approximately 3&#37; of osteoporotic vertebral fractures develop osteoporotic vertebral collapse (OVC) with neurological deficits, and such patients are recommended to be treated surgically. However, a proximal junctional fracture (PJFr) following surgery for OVC can be a serious concern. Therefore, the aim of this study is to identify the incidence and risk factors of PJFr following fusion surgery for OVC. METHODS: This study retrospectively analyzed registry data collected from facilities belonging to the Japan Association of Spine Surgeons with Ambition (JASA) in 2016. We retrospectively analyzed 403 patients who suffered neurological deficits due to OVC below T10 and underwent corrective surgery; only those followed up for ≥2 years were included. Potential risk factors related to the PJFr and their cut-off values were calculated using multivariate logistic regression analysis and receiver operating characteristic (ROC) analysis. RESULTS: Sixty-three patients (15.6&#37;) suffered PJFr during the follow-up (mean 45.7 months). In multivariate analysis, the grade of osteoporosis (grade 2, 3: adjusted odds ratio (aOR) 2.92; p=0.001) and lower instrumented vertebra (LIV) level (sacrum: aOR 6.75; p=0.003) were independent factors. ROC analysis demonstrated that lumbar bone mineral density (BMD) was a predictive factor (area under curve: 0.72, p=0.035) with optimal cut-off value of 0.61 g/cm2 (sensitivity, 76.5&#37;; specificity, 58.3&#37;), but that of the hip was not (p=0.228). CONCLUSIONS: PJFr was found in 16&#37; cases within 4 years after surgery; independent risk factors were severe osteoporosis and extended fusion to the sacrum. The lumbar BMD with cut-off value 0.61 g/cm2 may potentially predict PJFr. Our findings can help surgeons select perioperative adjuvant therapy, as well as a surgical strategy to prevent PJFr following surgery.

    DOI: 10.22603/ssrr.2018-0068

  • Surgical outcomes of spinal fusion for osteoporotic thoracolumbar vertebral fractures in patients with Parkinson's disease: what is the impact of Parkinson's disease on surgical outcome? International journal

    Kei Watanabe, Keiichi Katsumi, Masayuki Ohashi, Yohei Shibuya, Tomohiro Izumi, Toru Hirano, Naoto Endo, Takashi Kaito, Tomoya Yamashita, Hiroyasu Fujiwara, Yukitaka Nagamoto, Yuji Matsuoka, Hidekazu Suzuki, Hirosuke Nishimura, Hidetomi Terai, Koji Tamai, Atsushi Tagami, Syuta Yamada, Shinji Adachi, Toshitaka Yoshii, Shuta Ushio, Katsumi Harimaya, Kenichi Kawaguchi, Nobuhiko Yokoyama, Hidekazu Oishi, Toshiro Doi, Atsushi Kimura, Hirokazu Inoue, Gen Inoue, Masayuki Miyagi, Wataru Saito, Atsushi Nakano, Daisuke Sakai, Tadashi Nukaga, Shota Ikegami, Masayuki Shimizu, Toshimasa Futatsugi, Seiji Ohtori, Takeo Furuya, Sumihisa Orita, Shiro Imagama, Kei Ando, Kazuyoshi Kobayashi, Katsuhito Kiyasu, Hideki Murakami, Katsuhito Yoshioka, Shoji Seki, Michio Hongo, Kenichiro Kakutani, Takashi Yurube, Yasuchika Aoki, Masashi Oshima, Masahiko Takahata, Akira Iwata, Hirooki Endo, Tetsuya Abe, Toshinori Tsukanishi, Kazuyoshi Nakanishi, Kota Watanabe, Tomohiro Hikata, Satoshi Suzuki, Norihiro Isogai, Eijiro Okada, Haruki Funao, Seiji Ueda, Yuta Shiono, Kenya Nojiri, Naobumi Hosogane, Ken Ishii

    BMC musculoskeletal disorders   20 ( 1 )   103 - 103   2019.3

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    BACKGROUND: To date, there have been little published data on surgical outcomes for patients with PD with thoracolumbar OVF. We conducted a retrospective multicenter study of registry data to investigate the outcomes of fusion surgery for patients with Parkinson's disease (PD) with osteoporotic vertebral fracture (OVF) in the thoracolumbar junction. METHODS: Retrospectively registered data were collected from 27 universities and their affiliated hospitals in Japan. In total, 26 patients with PD (mean age, 76 years; 3 men and 23 women) with thoracolumbar OVF who underwent spinal fusion with a minimum of 2 years of follow-up were included (PD group). Surgical invasion, perioperative complications, radiographic sagittal alignment, mechanical failure (MF) related to instrumentation, and clinical outcomes were evaluated. A control group of 296 non-PD patients (non-PD group) matched for age, sex, distribution of surgical procedures, number of fused segments, and follow-up period were used for comparison. RESULTS: The PD group showed higher rates of perioperative complications (p < 0.01) and frequency of delirium than the non-PD group (p < 0.01). There were no significant differences in the degree of kyphosis correction, frequency of MF, visual analog scale of the symptoms, and improvement according to the Japanese Orthopaedic Association scoring system between the two groups. However, the PD group showed a higher proportion of non-ambulators and dependent ambulators with walkers at the final follow-up (p < 0.01). CONCLUSIONS: A similar surgical strategy can be applicable to patients with PD with OVF in the thoracolumbar junction. However, physicians should pay extra attention to intensive perioperative care to prevent various adverse events and implement a rehabilitation regimen to regain walking ability.

    DOI: 10.1186/s12891-019-2473-8

  • 一次修復不能な広範囲腱板断裂で偽性麻痺肩に対する鏡視下上方関節包再建術の術後成績

    山本 俊策, 二之宮 謙一, 合志 光平, 牟田口 滋, 佐々木 大, 坂本 悠磨, 横山 信彦

    整形外科と災害外科   67 ( 3 )   559 - 560   2018.9

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    Language:Japanese  

    【はじめに】一次修復不能な広範囲腱板断裂で偽性麻痺肩に対する鏡視下上方関節包再建術(以下ASCR)を行ったので、その治療成績を報告する。【対象と方法】2015年2月から2016年5月までにASCRを行った12肩(男性7肩、女性5肩)平均年齢72.5歳(67~80歳)を対象とした。術後平均観察期間は18.2ヵ月(13~28ヵ月)であった。可動域、MRI所見、JOAスコアを術前後で比較検討した。【結果】屈曲は術前平均52.5度が術後平均120.0度に、外転は術前平均51.2度が術後平均119.1度に改善した(p<0.05)。外旋は術前平均27.5度が術後平均30.0度と有意な改善は得られなかった。JOAスコアは術前47.5点から術後70.7点と有意に改善した(p<0.05)。術後屈曲90度以上の改善が得られなかったのは2例であり、いずれも立位での浜田分類グレード3であった。【結論】ASCRは良好な機能回復を認め、患者の満足度も高かった。良好な術後成績獲得のため適応を慎重に検討する必要があると思われた。(著者抄録)

  • Activation of ERK1/2 Causes Pazopanib Resistance via Downregulation of DUSP6 in Synovial Sarcoma Cells. International journal

    Nobuhiko Yokoyama, Tomoya Matsunobu, Yoshihiro Matsumoto, Jun-Ichi Fukushi, Makoto Endo, Mihoko Hatano, Akira Nabeshima, Suguru Fukushima, Seiji Okada, Yukihide Iwamoto

    Scientific reports   7   45332 - 45332   2017.3

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    Synovial sarcoma (SS) is a rare high-grade malignant mesenchymal tumour with a relatively poor prognosis despite intensive multimodal therapy. Although pazopanib, a multi-kinase inhibitor, is often used for advanced SS, most cases eventually become resistant to pazopanib. In the present study, we investigated the mechanisms of acquired pazopanib resistance in SS. To examine acquired pazopanib resistance, two SS cell lines, SYO-1 and HS-SY-II, were isolated after multiple selection steps with increasing concentrations of pazopanib. SYO-1 was also used in vivo. Then, pazopanib-resistant clones were investigated to assess potential mechanisms of acquired pazopanib resistance. Stable pazopanib-resistant clones were established and exhibited enhanced cell cycle progression, cell growth with increased ERK1/2 phosphorylation, and higher sensitivity than parental cells to a MEK-inhibitor, trametinib, both in vitro and in vivo. Furthermore, addition of low-dose trametinib partially reversed the pazopanib resistance. In the pazopanib-resistant clones, dual specificity phosphatase 6 (DUSP6) was downregulated. Inhibition of DUSP6 expression in parental HS-SY-II cells partially recapitulated acquired pazopanib resistance. Acquired pazopanib resistance in SS was associated with activation of ERK1/2 through downregulation of DUSP6 expression. Simultaneous treatment with pazopanib and a MEK inhibitor could be a promising strategy to overcome pazopanib resistance in SS.

    DOI: 10.1038/srep45332

  • Cadherin-11 regulates the metastasis of Ewing sarcoma cells to bone. International journal

    Mihoko Hatano, Yoshihiro Matsumoto, Jun-Ichi Fukushi, Tomoya Matsunobu, Makoto Endo, Seiji Okada, Kunio Iura, Satoshi Kamura, Toshifumi Fujiwara, Keiichiro Iida, Yuko Fujiwara, Akira Nabeshima, Nobuhiko Yokoyama, Suguru Fukushima, Yoshinao Oda, Yukihide Iwamoto

    Clinical & experimental metastasis   32 ( 6 )   579 - 91   2015.8

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    Ewing sarcoma (ES) is a small round-cell tumor of the bones and soft tissues. ES frequently causes distant metastases, particularly in the lung and bone, which worsens patient prognosis. Cadherin-11 (Cad-11) is an adhesion molecule that is highly expressed in osteoblasts. Its expression is associated with bone metastases in prostate and breast cancer patients, and is known to occur in ES. Here we investigated the effects of Cad-11 on bone metastases of ES. Human ES cell lines RD-ES, SK-ES-1, SK-N-MC, and TC-71 cells were transduced with lentivirus containing Cad-11 shRNA or control shRNA (ES/Cad-11 and ES/Ctr). RD-ES and TC-71 were infected with a lentivirus luciferase vector. Adhesion assays were performed using these cells and recombinant Cad-11-Fc chimera or mouse osteoblast cell line MC3T3-E1. Cell motility was investigated via wound-healing assay. Intracardiac injection of RD-ES/Cad-11 and RD-ES/Ctr was used to create a mouse model of experimental bone metastasis. The association between Cad-11 expression and bone metastases and clinical prognosis in ES patients was analyzed by immunohistochemistry. We found knockdown of Cad-11 in ES cells resulted in reduced attachment ability and cell motility. In a mouse model of metastasis, RD-ES/Cad-11 cells caused fewer metastases than RD-ES/Ctr cells. The expression of Cad-11 in ES patients was significantly related to bone metastases (P < 0.05, logistic regression) and poorer overall survival (P < 0.05, log-rank test). These findings may explain that Cad-11 in ES cells may be essential for cell adhesion and motility, and is a promising molecular target for patients with ES.

    DOI: 10.1007/s10585-015-9729-y

  • ビスフォスフォネート製剤内服加療中に生じた両側大腿骨非定型骨折の1例

    横山 信彦, 二之宮 謙一, 牟田口 滋, 合志 光平

    整形外科と災害外科   62 ( 2 )   316 - 319   2013.3

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    Language:Japanese  

    骨粗鬆症の罹患患者数は2011年現在で1280万人と言われており,大腿骨頸部骨折・椎体骨折の発生リスクを抑えるため,内服・注射などによる治療を行うことが推奨されている.それに伴い,ビスフォスフォネート製剤(以下,BP製剤)を長期にわたって用いる症例が増えてきている.近年BP製剤の長期内服患者において,非外傷性あるいは低エネルギー外傷性の大腿骨転子下骨折や大腿骨骨幹部骨折などのいわゆる非定型骨折を生じるという報告が散見される.今回,ステロイド長期内服による骨粗鬆症に対してBP製剤内服を開始し,内服開始から5年目および8年目に両側大腿骨非定型骨折と思われる大腿骨転子下骨折を受傷した症例を経験したため報告する.(著者抄録)

  • 腰部神経根症に対する神経根ブロックの有効性

    近間 知尚, 生田 光, 横山 信彦, 高橋 祐介, 北村 貴弘, 仙波 英之, 志田原 哲

    整形外科と災害外科   60 ( 1 )   95 - 100   2011.3

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    Language:Japanese  

    目的:腰椎椎間板ヘルニア(以下LDH)及び腰部脊柱管狭窄症(以下LCS)による腰部神経根症に対する選択的神経根ブロック(以下SNRB)の有効性を調査した.対象:2008年4月~2009年11月にSNRBを施行した78例(LDH49例・LCS29例)を対象とした.方法:SNRBは手術適応のある患者に原則1回行い,外来にて透視下に施行した.臨床成績は最終観察時にMacnabの判定基準にて評価した.各項目(年齢・罹病期間・各時期のVAS score・効果持続時間)と臨床成績との相関関係を評価した.結果:有効率はLDH47&#37;,LCS24&#37;とLDHが有意に高かった.手術移行率はLDH 39&#37;,LCS 59&#37;であった.有効群では24時間以上効果が持続する症例が有意に多かった.結語:神経根症を有するLDH及びLCSに対し,SNRBは手術療法前に一度は試みてもよい保存療法であると考えられた.(著者抄録)

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Presentations

  • AYA世代への治療サポート~将来の就労支援も含めて~ AYA世代がん患者の治療サポート 整形外科医師の立場から Invited

    @横山信彦,@園田顕三,@進藤史代,@中山秀樹

    第 71回 日本職業・災害医学学会学術大会  2023.12 

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    Event date: 2023.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:アクロス福岡   Country:Japan  

  • 当院における大腿骨近位転移性骨腫瘍手術症例の術後生存期間に関する検討

    @横山信彦,@薛宇孝,@石原新

    第146回西日本整形・災害外科学会学術集会  2023.11 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:沖縄コンベンションセンター   Country:Japan  

  • 転移性骨腫瘍に対するデノスマブ投与の当院における現状と投与中断による骨関連事象発生に関する検討

    @横山信彦,@薛宇孝,@伊東良広

    第56回日本整形外科学会骨・軟部腫瘍学術集会  2023.7 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京王プラザホテル   Country:Japan  

  • 大腿骨に骨皮質内転移を生じた呼吸器原発悪性腫瘍の2例

    @横山信彦,@薛宇孝,@伊東良広

    第145回西日本整形・災害外科学会学術集会  2023.6 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:アクロス福岡   Country:Japan  

Professional Memberships

  • 日本足の外科学会

  • 日本サルコーマ治療研究学会

  • 日本癌治療学会

  • 西日本整形災害外科学会

  • 日本整形外科学会

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2024

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

  • Screening of academic papers

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

    Proceedings of domestic conference Number of peer-reviewed papers:7

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Surgical Clinical Medicine / Orthopedic Surgery

Clinician qualification

  • 運動器リハビリテーション医

    The Japanese Orthopaedic Association(JOA)

  • Preceptor

    The Japanese Orthopaedic Association(JOA)

  • Specialist

    The Japanese Orthopaedic Association(JOA)

  • 骨・軟部腫瘍医

    The Japanese Orthopaedic Association(JOA)

  • がん治療認定医

    日本がん治療認定医機構

Year of medical license acquisition

  • 2007