Updated on 2024/07/28

Information

 

写真a

 
MIURA TAKASHI
 
Organization
Faculty of Medical Sciences Research Center for Human Disease Modeling Professor
Faculty of Medical Sciences Research Center for Human Disease Modeling(Joint Appointment)
School of Medicine Department of Medicine(Joint Appointment)
Graduate School of Medical Sciences Department of Medicine(Joint Appointment)
Graduate School of Medical Sciences Department of Health Care Administration and Management(Joint Appointment)
Title
Professor
Contact information
メールアドレス
Tel
0926426048
Homepage
External link

Degree

  • Ph. D

Research History

  • 2000/4/1 京都大学大学院医学研究科

Research Interests・Research Keywords

  • Research theme:Mathematical modeling of biological pattern formation phenomena and their experimental verification

    Keyword:Pattern formation, mathematical modeling, reaction-diffusion, particle system, developmental biology

    Research period: 1996.4 - 2013.2

Papers

  • Analyzing the effect of cell rearrangement on Delta-Notch pattern formation Reviewed

    Toshiki Oguma, Hisako Takigawa-Imamura, Tomoyasu Shinoda, Shuntaro Ogura, Akiyoshi Uemura, Takaki Miyata, Philip K. Maini, Takashi Miura

    Physical Review E   107 ( 6 )   2023.6

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    DOI: 10.1103/physreve.107.064404

  • Mechanism of interdigitation formation at apical boundary of MDCK cell Reviewed International journal

    Shintaro Miyazaki, Tetsuhisa Otani, Kei Sugihara, Toshihiko Fujimori, Mikio Furuse, Takashi Miura

    iScience   106594 - 106594   2023.4

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    DOI: 10.1016/j.isci.2023.106594

  • Tmsb10 triggers fetal Leydig differentiation by suppressing the RAS/ERK pathway Reviewed International journal

    Miki Inoue, Takashi Baba, Fumiya Takahashi, Miho Terao, Shogo Yanai, Yuichi Shima, Daisuke Saito, Kei Sugihara, Takashi Miura, Shuji Takada, Mikita Suyama, Yasuyuki Ohkawa, Ken-ichirou Morohashi

    Communications Biology   5 ( 1 )   974 - 974   2022.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s42003-022-03941-5

  • Quantitative modeling of regular retinal microglia distribution Reviewed

    Yoshie Endo, Daisuke Asanuma, Shigeyuki Namiki, Kei Sugihara, Kenzo Hirose, Akiyoshi Uemura, Yoshiaki Kubota, Takashi Miura

    Scientific Reports   11 ( 1 )   2021.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-01820-3

  • Mathematical Modeling of Dynamic Cellular Association Patterns in Seminiferous Tubules Reviewed International journal

    Mari Kawamura, Kei Sugihara, Hisako Takigawa-Imamura, Toshiyuki Ogawa, Takashi Miura

    Bulletin of Mathematical Biology   83 ( 4 )   33 - 33   2021.4

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    DOI: 10.1007/s11538-021-00863-x

  • A new perfusion culture method with a self-organized capillary network Reviewed International journal

    Kei Sugihara, Yoshimi Yamaguchi, Shiori Usui, Yuji Nashimoto, Sanshiro Hanada, Etsuko Kiyokawa, Akiyoshi Uemura, Ryuji Yokokawa, Koichi Nishiyama, Takashi Miura

    PLOS ONE   15 ( 10 )   e0240552 - e0240552   2020.10

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    DOI: 10.1371/journal.pone.0240552

  • Mechanisms of endothelial cell coverage by pericytes: computational modelling of cell wrapping and in vitro experiments Reviewed International journal

    Kei Sugihara, Saori Sasaki, Akiyoshi Uemura, Satoru Kidoaki, Takashi Miura

    Journal of The Royal Society Interface   17 ( 162 )   20190739 - 20190739   2020.1

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    DOI: 10.1098/rsif.2019.0739

  • Integrating perfusable vascular networks with a three-dimensional tissue in a microfluidic device. Reviewed International journal

    Yuji Nashimoto, Tomoya Hayashi, Itsuki Kunita, Akiko Nakamasu, Yu-Suke Torisawa, Masamune Nakayama, Hisako Takigawa-Imamura, Hidetoshi Kotera, Koichi Nishiyama, Takashi Miura, Ryuji Yokokawa

    Integrative biology : quantitative biosciences from nano to macro   9 ( 6 )   506 - 518   2017.6

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    DOI: 10.1039/c7ib00024c

  • Exogenous Cellulase Switches Cell Interdigitation to Cell Elongation in an RIC1-dependent Manner in Arabidopsis thaliana Cotyledon Pavement Cells Reviewed

    Takumi Higaki, Hisako Takigawa-Imamura, Kae Akita, Natsumaro Kutsuna, Ryo Kobayashi, Seiichiro Hasezawa, Takashi Miura

    Plant and Cell Physiology   pcw183 - pcw183   2016.12

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    DOI: 10.1093/pcp/pcw183

  • A Theoretical Model of Jigsaw-Puzzle Pattern Formation by Plant Leaf Epidermal Cells Reviewed

    Takumi Higaki, Natsumaro Kutsuna, Kae Akita, Hisako Takigawa-Imamura, Kenji Yoshimura, Takashi Miura

    PLOS COMPUTATIONAL BIOLOGY   12 ( 4 )   e1004833   2016.4

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    DOI: 10.1371/journal.pcbi.1004833

  • Dynamics of VEGF matrix-retention in vascular network patterning Reviewed

    Physical Biology   10 ( 6 )   066007 - 066007   2013.12

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    DOI: 10.1088/1478-3975/10/6/066007

  • Reaction-Diffusion Model as a Framework for Understanding Biological Pattern Formation Reviewed

    Shigeru Kondo, Takashi Miura

    Science   329 ( 5999 )   1616 - 1620   2010.9

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    DOI: 10.1126/science.1179047

  • Mechanism of skull suture maintenance and interdigitation Reviewed

    Takashi Miura, Chad A. Perlyn, Masato Kinboshi, Naomichi Ogihara, Mikiko Kobayashi-Miura, Gillian M. Morriss-Kay, Kohei Shiota

    Journal of Anatomy   215 ( 6 )   642 - 655   2009.12

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    DOI: 10.1111/j.1469-7580.2009.01148.x

  • The cyst-branch difference in developing chick lung results from a different morphogen diffusion coefficient Reviewed

    Miura, T., Hartmann, D., Kinboshi, M., Komada, M., Ishibashi, M., Shiota, K.

    Mechanisms of Development   126 ( 3-4 )   160 - 172   2009.4

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    DOI: 10.1016/j.mod.2008.11.006

  • Modelling in vitro lung branching morphogenesis during development Reviewed

    Dirk Hartmann, Takashi Miura

    Journal of Theoretical Biology   242 ( 4 )   862 - 872   2006.10

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    DOI: 10.1016/j.jtbi.2006.05.009

  • Mixed-mode pattern in Doublefoot mutant mouse limb—Turing reaction–diffusion model on a growing domain during limb development Reviewed

    240 ( 4 )   562 - 573   2006.6

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    DOI: 10.1016/j.jtbi.2005.10.016

  • Speed of pattern appearance in reaction-diffusion models: implications in the pattern formation of limb bud mesenchyme cells Reviewed

    Takashi Miura, Philip K. Maini

    Bulletin of Mathematical Biology   66 ( 4 )   627 - 649   2004.7

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    DOI: 10.1016/j.bulm.2003.09.009

  • Depletion of FGF acts as a lateral inhibitory factor in lung branching morphogenesis in vitro Reviewed

    Takashi Miura, Kohei Shiota

    Mechanisms of Development   116 ( 1-2 )   29 - 38   2002.8

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    DOI: 10.1016/s0925-4773(02)00132-6

  • TGFβ2 acts as an 'activator' molecule in reaction-diffusion model and is involved in cell sorting phenomenon in mouse limb micromass culture Reviewed

    217 ( 3 )   241 - 249   2000.4

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    It was previously speculated that TGFβ acts as an 'activator'-molecule in chondrogenic pattern formation in the limb micromass culture system, but its precise role and relationship with the cell sorting phenomenon have not been properly studied. In the present study, we examined whether the TGFβ2 molecule satisfies the necessary conditions for an 'activator'-molecule in the reaction-diffusion model. Firstly, we showed that TGFβ2 became localized at chondrogenic sites during the establishment of a chondrogenic pattern, and exogenous TGFβ2 promoted chondrogenesis when added in the culture medium. Secondly, TGFβ2 protein was shown to promote the production of its own mRNA after 3 hr, indicating that a positive feedback mechanism exists which may be responsible for the emergence of the chondrogenic pattern. We then found that when locally applied with beads, TGFβ2 suppressed chondrogenesis around the beads, indicating it induces the lateral inhibitory mechanism, which is a key element for the formation of the periodic pattern. We also examined the possible effects of TGFβ2 on the cell sorting phenomenon and found that TGFβ2 exerts differential chemotactic activity on proximal and distal mesenchyme cells of the limb bud, and at very early phases of differentiation TGFβ2 promotes the expression of N-cadherin protein which is known to be involved in pattern formation in this culture system. These findings suggest that TGFβ2 acts as an 'activator'-like molecule in chondrogenic pattern formation in vitro, and is possibly responsible for the cell sorting phenomenon. (C) 2000 Wiley- Liss, Inc.

    DOI: 10.1002/(SICI)1097-0177(200003)217:3<241::AID-DVDY2>3.0.CO;2-K

  • Stripe and spot selection in cusp patterning of mammalian molar formation Reviewed

    Wataru Morita, Naoki Morimoto, Keishi Otsu, Takashi Miura

    Scientific Reports   12 ( 1 )   2022.12

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    DOI: 10.1038/s41598-022-13539-w

  • Electrochemical sensing of oxygen metabolism for a three-dimensional cultured model with biomimetic vascular flow Reviewed

    Yuji Nashimoto, Rei Mukomoto, Takuto Imaizumi, Takato Terai, Shotaro Shishido, Kosuke Ino, Ryuji Yokokawa, Takashi Miura, Kunishige Onuma, Masahiro Inoue, Hitoshi Shiku

    Biosensors and Bioelectronics   114808 - 114808   2022.10

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    DOI: 10.1016/j.bios.2022.114808

  • Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins. Reviewed International journal

    Shinya Yuge, Koichi Nishiyama, Yuichiro Arima, Yasuyuki Hanada, Eri Oguri-Nakamura, Sanshiro Hanada, Tomohiro Ishii, Yuki Wakayama, Urara Hasegawa, Kazuya Tsujita, Ryuji Yokokawa, Takashi Miura, Toshiki Itoh, Kenichi Tsujita, Naoki Mochizuki, Shigetomo Fukuhara

    Nature communications   13 ( 1 )   2594 - 2594   2022.5

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    DOI: 10.1038/s41467-022-30197-8

  • Mathematical modeling of palatal suture pattern formation: morphological differences between sagittal and palatal sutures Reviewed

    Nobuhide Shibusawa, Yoshie Endo, Naoki Morimoto, Ichiro Takahashi, Takashi Miura

    Scientific Reports   11 ( 1 )   2021.12

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    DOI: 10.1038/s41598-021-88255-y

  • Effective nonlocal kernels on reaction–diffusion networks Reviewed

    509   110496 - 110496   2021.1

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    DOI: 10.1016/j.jtbi.2020.110496

  • Mesenchymal glioblastoma-induced mature de-novo vessel formation of vascular endothelial cells in a microfluidic device Reviewed

    Takeo Amemiya, Nobuhiro Hata, Masahiro Mizoguchi, Ryuji Yokokawa, Yoichiro Kawamura, Ryusuke Hatae, Yuhei Sangatsuda, Daisuke Kuga, Yutaka Fujioka, Kosuke Takigawa, Yojiro Akagi, Koji Yoshimoto, Koji Iihara, Takashi Miura

    Molecular Biology Reports   2021.1

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    DOI: 10.1007/s11033-020-06061-7

  • Mechanism underlying dynamic scaling properties observed in the contour of spreading epithelial monolayer Reviewed International journal

    Toshiki Oguma, Hisako Takigawa-Imamura, Takashi Miura

    Physical Review E   102 ( 6 )   062408 - 062408   2020.12

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    DOI: 10.1103/physreve.102.062408

  • Noise-induced scaling in skull suture interdigitation Reviewed

    Yuto Naroda, Yoshie Endo, Kenji Yoshimura, Hiroshi Ishii, Shin-Ichiro Ei, Takashi Miura

    PLOS ONE   15 ( 12 )   e0235802 - e0235802   2020.12

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    DOI: 10.1371/journal.pone.0235802

  • Remodeling mechanisms determine size distributions in developing retinal vasculature Reviewed International journal

    Osamu Iizuka, Shotaro Kawamura, Atsushi Tero, Akiyoshi Uemura, Takashi Miura

    PLOS ONE   15 ( 10 )   e0235373 - e0235373   2020.10

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    DOI: 10.1371/journal.pone.0235373

  • Oxygen consumption rate of tumour spheroids during necrotic-like core formation. Reviewed International journal

    Rei Mukomoto, Yuji Nashimoto, Takato Terai, Takuto Imaizumi, Kaoru Hiramoto, Kosuke Ino, Ryuji Yokokawa, Takashi Miura, Hitoshi Shiku

    The Analyst   2020.7

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    DOI: 10.1039/d0an00979b

  • A new microcirculation culture method with a self-organized capillary network Reviewed

    Kei Sugihara, Yoshimi Yamaguchi, Shiori Usui, Yuji Nashimoto, Sanshiro Hanada, Etsuko Kiyokawa, Akiyoshi Uemura, Ryuji Yokokawa, Koichi Nishiyama, Takashi Miura

    bioRxiv   2020.5

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    DOI: 10.1101/2020.05.12.067165

  • Vascularized cancer on a chip: The effect of perfusion on growth and drug delivery of tumor spheroid Reviewed International journal

    Yuji Nashimoto, Ryu Okada, Sanshiro Hanada, Yuichiro Arima, Koichi Nishiyama, Takashi Miura, Ryuji Yokokawa

    Biomaterials   229   119547 - 119547   2020.1

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    DOI: 10.1016/j.biomaterials.2019.119547

  • Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity Reviewed International journal

    Tetsuhisa Otani, Thanh Phuong Nguyen, Shinsaku Tokuda, Kei Sugihara, Taichi Sugawara, Kyoko Furuse, Takashi Miura, Klaus Ebnet, Mikio Furuse

    Journal of Cell Biology   218 ( 10 )   3372 - 3396   2019.10

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    DOI: 10.1083/jcb.201812157

  • Combining Turing and 3D vertex models reproduces autonomous multicellular morphogenesis with undulation, tubulation, and branching Reviewed

    Satoru Okuda, Takashi Miura, Yasuhiro Inoue, Taiji Adachi, Mototsugu Eiraku

    SCIENTIFIC REPORTS   8 ( 1 )   2386   2018.6

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    DOI: 10.1038/s41598-018-24858-2

  • MUTE Directly Orchestrates Cell-State Switch and the Single Symmetric Division to Create Stomata Reviewed

    Soon-Ki Han, Xingyun Qi, Kei Sugihara, Jonathan H. Dang, Takaho A. Endo, Kristen L. Miller, Eun-Deok Kim, Takashi Miura, Keiko U. Torii

    Developmental Cell   45 ( 3 )   303 - 315.e5   2018.5

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    DOI: 10.1016/j.devcel.2018.04.010

  • Elasticity-based boosting of neuroepithelial nucleokinesis via indirect energy transfer from mother to daughter Reviewed

    Tomoyasu Shinoda, Arata Nagasaka, Yasuhiro Inoue, Ryo Higuchi, Yoshiaki Minami, Kagayaki Kato, Makoto Suzuki, Takefumi Kondo, Takumi Kawaue, Kanako Saito, Naoto Ueno, Yugo Fukazawa, Masaharu Nagayama, Takashi Miura, Taiji Adachi, Takaki Miyata

    PLOS BIOLOGY   16 ( 4 )   2018.4

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    DOI: 10.1371/journal.pbio.2004426

  • 組織の形態形成解明に資するマイクロ流体デバイス内での血管網の構築とその応用 Reviewed

    梨本 裕司, 寺岡 佑佳子, 有馬 勇一郎, 花田 三四郎, 中益 朗子, 小寺 秀俊, 西山 功一, 三浦 岳, 横川 隆司

    電学論E   138 ( 7 )   275 - 280   2018.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1541/ieejsmas.138.275

  • Perfusable Vascular Network with a Tissue Model in a Microfluidic Device Reviewed International journal

    Yuji Nashimoto, Yukako Teraoka, Ramin Banan Sadeghian, Akiko Nakamasu, Yuichiro Arima, Sanshiro Hanada, Hidetoshi Kotera, Koichi Nishiyama, Takashi Miura, Ryuji Yokokawa

    Journal of Visualized Experiments   ( 134 )   2018.4

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    DOI: 10.3791/57242

  • Mathematical modeling for meshwork formation of endothelial cells in fibrin gels Reviewed

    Daiki Sasaki, Hitomi Nakajima, Yoshimi Yamaguchi, Ryuji Yokokawa, Shin-Ichiro Ei, Takashi Miura

    Journal of Theoretical Biology   429   95 - 104   2017.9

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    DOI: 10.1016/j.jtbi.2017.06.012

  • ENGINEERING A THREE-DIMENSIONAL TISSUE MODEL WITH A PERFUSABLE VASCULATURE IN A MICROFLUIDIC DEVICE Reviewed

    Yuji Nashimoto, Itsuki Kunita, Akiko Nakamasu, Yu-suke Torisawa, Masamune Nakayama, Hidetoshi Kotera, Koichi Nishiyama, Takashi Miura, Ryuji Yokokawa

    30TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2017)   592 - 595   2017.4

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    DOI: 10.1109/MEMSYS.2017.7863476

  • Reelin transiently promotes N-cadherin–dependent neuronal adhesion during mouse cortical development Reviewed International journal

    114 ( 8 )   2048 - 2053   2017.2

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    Reelin is an essential glycoprotein for the establishment of the highly organized six-layered structure of neurons of the mammalian neocortex. Although the role of Reelin in the control of neuronal migration has been extensively studied at the molecular level, the mechanisms underlying Reelin-dependent neuronal layer organization are not yet fully understood. In this study, we directly showed that Reelin promotes adhesion among dissociated neocortical neurons in culture. The Reelin-mediated neuronal aggregation occurs in an N-cadherin–dependent manner, both in vivo and in vitro. Unexpectedly, however, in a rotation culture of dissociated neocortical cells that gradually reaggregated over time, we found that it was the neural progenitor cells [radial glial cells (RGCs)], rather than the neurons, that tended to form clusters in the presence of Reelin. Mathematical modeling suggested that this clustering of RGCs could be recapitulated if the Reelin-dependent promotion of neuronal adhesion were to occur only transiently. Thus, we directly measured the adhesive force between neurons and N-cadherin by atomic force microscopy, and found that Reelin indeed enhanced the adhesiveness of neurons to N-cadherin; this enhanced adhesiveness began to be observed at 30 min after Reelin stimulation, but declined by 3 h. These results suggest that Reelin transiently (and not persistently) promotes N-cadherin–mediated neuronal aggregation. When N-cadherin and stabilized β-catenin were overexpressed in the migrating neurons, the transfected neurons were abnormally distributed in the superficial region of the neocortex, suggesting that appropriate regulation of N-cadherin–mediated adhesion is important for correct positioning of the neurons during neocortical development.

    DOI: 10.1073/pnas.1615215114

  • A new mathematical model for pattern formation by cranial sutures Reviewed

    Kenji Yoshimura, Ryo Kobayashi, Tomohisa Ohmura, Yoshinaga Kajimoto, Takashi Miura

    Journal of Theoretical Biology   408   66 - 74   2016.11

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    DOI: 10.1016/j.jtbi.2016.08.003

  • Theoretical Models of Vascular Pattern Formation. Reviewed

    Takashi Miura

    Fukuoka igaku zasshi = Hukuoka acta medica   107 ( 9 )   161 - 168   2016.9

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    Theoretical Models of Vascular Pattern Formation.

    DOI: 10.15017/1787037

  • Notch-mediated lateral inhibition regulates proneural wave propagation when combined with EGF-mediated reaction diffusion Reviewed

    Makoto Sato, Tetsuo Yasugi, Yoshiaki Minami, Takashi Miura, Masaharu Nagayama

    Proceedings of the National Academy of Sciences   113 ( 35 )   E5153 - E5162   2016.8

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    DOI: 10.1073/pnas.1602739113

  • Tissue culture on a chip: Developmental biology applications of self-organized capillary networks in microfluidic devices Reviewed

    Takashi Miura, Ryuji Yokokawa

    Development, Growth & Differentiation   58 ( 6 )   505 - 515   2016.8

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    DOI: 10.1111/dgd.12292

  • Rat Articular Cartilages Change Their Tissue and Protein Compositions During Perinatal Period Reviewed International journal

    M. Kobayashi-Miura, T. Miura, H. Osago, Y. Yamaguchi, T. Aoyama, T. Tanabe, K.-i. Matsumoto, Y. Fujita

    Anatomia, Histologia, Embryologia   45 ( 1 )   9 - 18   2016.2

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    DOI: 10.1111/ahe.12165

  • VASCULAR NETWORK FORMATION FOR A LONG-TERM SPHEROID CULTURE BY CO-CULTURING ENDOTHELIAL CELLS AND FIBROBLASTS Reviewed

    Tomoya Hayashi, Hisako Takigawa-Imamura, Koichi Nishiyama, Hirofumi Shintaku, Hidetoshi Kotera, Takashi Miura, Ryuji Yokokawa

    2015 28TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2015)   476 - 479   2015.4

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  • Models of lung branching morphogenesis Reviewed

    Takashi Miura

    Journal of Biochemistry   157 ( 3 )   121 - 127   2015.3

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    DOI: 10.1093/jb/mvu087

  • Anatomical study for SLAP lesion repair Reviewed

    Ryuzo Arai, Masahiko Kobayashi, Hideto Harada, Hiroyuki Tsukiyama, Takahiko Saji, Yoshinobu Toda, Yoshihiro Hagiwara, Takashi Miura, Shuichi Matsuda

    Knee Surgery, Sports Traumatology, Arthroscopy   22 ( 2 )   435 - 441   2014.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00167-013-2385-3

  • Turing and Wolpert Work Together During Limb Development Reviewed

    Takashi Miura

    Science Signaling   6 ( 270 )   pe14 - pe14   2013.4

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    DOI: 10.1126/scisignal.2004038

  • [What we can see through mathematical modeling of biological pattern formation] Reviewed

    Takashi Miura

    Fukuoka igaku zasshi = Hukuoka acta medica   2013.4

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  • Fiber components of the shoulder superior labrum Reviewed

    Ryuzo Arai, Masahiko Kobayashi, Yoshinobu Toda, Shinichiro Nakamura, Takashi Miura, Takashi Nakamura

    Surgical and Radiologic Anatomy   34 ( 1 )   49 - 56   2012.1

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    DOI: 10.1007/s00276-011-0840-8

  • Application of reaction-diffusion equation to biological pattern formation Reviewed

    Miura, T., Nagayama, M.

    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   2010.4

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  • In vitro vasculogenesis models revisited - Measurement of VEGF diffusion in matrigel Reviewed

    T. Miura, R. Tanaka

    Mathematical Modelling of Natural Phenomena   4 ( 4 )   118 - 130   2009.1

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    DOI: 10.1051/mmnp/20094404

  • Hedgehog signaling is involved in development of the neocortex Reviewed

    Masakazu Komada, Hiroto Saitsu, Masato Kinboshi, Takashi Miura, Kohei Shiota, Makoto Ishibashi

    Development   135 ( 16 )   2717 - 2727   2008.7

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    DOI: 10.1242/dev.015891

  • Modeling Lung Branching Morphogenesis Reviewed

    Takashi Miura

    Current Topics in Developmental Biology   291 - 310   2008.4

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    DOI: 10.1016/s0070-2153(07)81010-6

  • Mathematical analysis of a free-boundary model for lung branching morphogenesis Reviewed

    Dirk Hartmann, Takashi Miura

    Mathematical Medicine and Biology: A Journal of the IMA   24 ( 2 )   209 - 224   2007.6

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    DOI: 10.1093/imammb/dql029

  • [Turing reaction-diffusion model in developmental biology: application to limb skeletal pattern formation]. Reviewed

    Takashi Miura

    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   50 ( 15 )   1955 - 1961   2005.12

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    [Turing reaction-diffusion model in developmental biology: application to limb skeletal pattern formation].

  • Disruption of actin cytoskeleton and anchorage-dependent cell spreading induces apoptotic death of mouse neural crest cells cultured in vitro Reviewed

    Atsushi Hinoue, Toshiya Takigawa, Takashi Miura, Yoshihiko Nishimura, Shigehiko Suzuki, Kohei Shiota

    Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology   282 ( 2 )   130 - 137   2005.2

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    DOI: 10.1002/ar.a.20150

  • A mesenchyme-free culture system to elucidate the mechanism of otic vesicle morphogenesis Reviewed

    Takashi Miura, Kohei Shiota, Gillian Morriss-Kay

    Journal of Anatomy   205 ( 4 )   297 - 312   2004.10

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.0021-8782.2004.00335.x

  • Periodic pattern formation in reaction-diffusion systems: An introduction for numerical simulation Reviewed

    Takashi Miura, Philip K. Maini

    Anatomical Science International   79 ( 3 )   112 - 123   2004.9

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    DOI: 10.1111/j.1447-073x.2004.00079.x

  • Stage-dependency of the effect of ethanol on chondrogenic differentiation in mouse limb micromass culture

    Miura T., Kobayashi M., Shiota K.

    Congenital anomalies   41 ( 3 )   249 - 250   2001.9

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    Stage-dependency of the effect of ethanol on chondrogenic differentiation in mouse limb micromass culture

  • A novel method for analysis of the periodicity of chondrogenic patterns in limb bud cell culture: correlation of in vitro pattern formation with theoretical models Reviewed

    Takashi Miura, Masaru Komori, Kohei Shiota

    Anatomy and Embryology   201 ( 5 )   419 - 428   2000.4

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    DOI: 10.1007/s004290050329

  • Time-lapse observation of branching morphogenesis of the lung bud epithelium in mesenchyme-free culture and its relationship with the localization of actin filaments Reviewed

    Takashi Miura, Kohei Shiota

    International Journal of Developmental Biology   44 ( 8 )   899 - 902   2000.4

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  • Extracellular matrix environment influences chondrogenic pattern formation in limb bud micromass culture: Experimental verification of theoretical models Reviewed

    Takashi Miura, Kohei Shiota

    The Anatomical Record   258 ( 1 )   100 - 107   2000.1

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    DOI: 10.1002/(sici)1097-0185(20000101)258:1<100::aid-ar11>3.0.co;2-3

  • Computerized three-dimensional reconstruction of human embryos and their organs using the "NIH image" software Reviewed

    Takashi Miura, Masaru Komori, Tadashi Takahashi, Kohei Shiota

    Kaibogaku zasshi. Journal of anatomy   70 ( 4 )   353 - 361   1995.4

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Books

  • 発生の数理

    三浦, 岳

    京都大学学術出版会  2015.12 

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  • 発生の数理

    三浦 岳( Role: Sole author)

    2015.12 

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  • チューリング : 総特集 = A. M. Turing

    三浦 岳

    青土社  2012.10 

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    Responsible for pages:総ページ数:222p   Language:Japanese  

Presentations

  • マウス四肢原基微小集積培養系における軟骨形成パターンのメカニズム Invited

    三浦 岳

    日本解剖学会  2000.3 

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  • 四肢間葉細胞微小集積培養系の形態形成のメカニズム

    三浦 岳,塩田 浩平

    第33回日本発生生物学会  2000.5 

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  • Mechanisms of Pattern Formation in Limb Bud Micromass Culture: Possible Relationship with in vivo Pattern Formation

    Takashi Miura

    2000.7 

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    Mechanisms of Pattern Formation in Limb Bud Micromass Culture: Possible Relationship with in vivo Pattern Formation

  • Morphogenesis of Embryonic Lung Epithelium in Vitro: Possible Relationship with Theoretical Models

    Takashi Miura

    2000.11 

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    Morphogenesis of Embryonic Lung Epithelium in Vitro: Possible Relationship with Theoretical Models

  • マウス四肢原基微小集積培養系における軟骨パターン形成のメカニズム Invited

    三浦 岳

    日本先天異常学会  2001.7 

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  • Role of actin filaments in branching morphogenesis of the embryonic lung epithelium in vitro

    Takashi Miura

    14th ICDB  2001.7 

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    Role of actin filaments in branching morphogenesis of the embryonic lung epithelium in vitro

  • Speed of pattern appearance in reaction-diffusion system

    Takashi Miura

    Mathematical Understanding of Complex Patterns in the Life Sciences  2003.3 

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    Speed of pattern appearance in reaction-diffusion system

  • Mesenchyme-free otic vesicle culture to elucidate the mechanism of morphogenesis

    Takashi Miura, Kohei Shiota, Gillian Morriss-Kay

    Inner Ear Workshop  2003.9 

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  • Thin digits in the Doublefoot mutant limb: mixed-mode pattern in reaction-diffusion model of the growing domain

    Takashi Miura, GIllian Morriss-Kay, Philip, K. Maini

    SMB2004  2004.7 

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  • Manipulating expression of the ventral otic vesicle marker Pax-2 in a mesenchyme-free culture system

    Takashi Miura, Kohei Shiota, GIllian Morriss-Kay

    IFAA  2004.8 

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  • Digit splitting pattern in Doublefoot mutant mice limb buds - Relationship with reaction-diffusion model on growing domain Invited

    Takashi Miura

    2004.9 

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  • Doublefoot mutant マウスにおける四肢の変異パターン – 拡大領域上での Turing パターンとの関連

    三浦 岳

    形の科学会  2005.6 

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  • Modelling dynamics of skull suture pattern formation during development

    Takashi Miura, Kohei Shiota

    2005.7 

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    Modelling dynamics of skull suture pattern formation during development

  • 頭蓋骨縫合線の パターン形成のモデル化

    三浦 岳

    発生生物学会  2006.6 

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  • 頭蓋骨縫合線のパターン形成の数理モデル化とその実験的検証

    三浦岳

    かたちまつり2006  2006.11 

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  • Cyst-branch difference in chick lung

    Takashi Miura

    2007.3 

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    Cyst-branch difference in chick lung

  • Analysis of chick lung branching morphogenesis using mathematical model

    Takashi Miura, Kohei Shiota

    2007.3 

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  • Cyst-branch difference of chick lung results from different morphogen diffusion coefficient

    Takashi Miura

    2007.5 

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  • Noninvasive observation of mouse skull using microCT

    Miura, T, Morimoto, N, Ogihara, N, Shiota K

    2007.7 

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  • Mechanism of lung branching morphogenesis

    Takashi Miura

    Societr of Mathematical Biology Annual Meeting  2007.7 

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    Mechanism of lung branching morphogenesis

  • 発生に於ける形態形成現象をどうモデル化するか?

    三浦 岳

    宇治化研セミナー  2008.1 

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  • 生物の二つの「形」

    三浦 隆

    非平衡現象と協調現象の数理  2008.1 

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  • Time course observation of mouse skull development using microCT

    Takashi Miura

    2008.3 

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    Time course observation of mouse skull development using microCT

  • Modelling lung branching morphogenesis

    Takashi Miura

    2008.4 

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    Modelling lung branching morphogenesis

  • 生物の形づくりのしくみ

    三浦 岳

    マイクロデバイス集中講義  2008.5 

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  • In vitro vasculogenesis model revisited: Measurement of VEGF diffusion

    Takashi Miura

    2008.5 

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    In vitro vasculogenesis model revisited: Measurement of VEGF diffusion

  • 頭蓋骨の縫合線のパターン形成

    三浦 岳

    パターンダイナミクスの数理とその周辺  2008.6 

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  • Visualizing morphogen distribution in lumen

    Takashi Miura

    SDB meeting  2008.7 

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    Visualizing morphogen distribution in lumen

  • Mechanism of lung branching morphogenesis

    Takashi Miura

    2008.8 

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  • 肺の枝分かれ形成の メカニズム

    三浦 岳

    「複雑系情報学に基づく創発的なデータ生成過程のモデル化」に関する研究会  2008.9 

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  • 肺の枝分かれ構造の形成機構

    三浦 岳

    定量生物学の会  2009.1 

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  • 似てるものは同じ?

    三浦 岳

    数理研研究集会  2009.1 

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  • Mechanism of lung branching morphogenesis

    Takashi Miura

    2009.1 

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    Mechanism of lung branching morphogenesis

  • Expression of proximodistal markers during chick lung development

    Takashi Miura

    2009.3 

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    Expression of proximodistal markers during chick lung development

  • Expression of proximodistal markers during chick lung development

    Takashi Miura

    2009.5 

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  • Expression of proximodistal markers during chick lung development

    Takashi Miura

    ISDB meeting  2009.9 

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    Expression of proximodistal markers during chick lung development

  • 自発的パターン形成における拡散と領域成長の役割:培養系での形態制御の可能性

    三浦 岳

    バイオマテリアル学会  2009.11 

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  • Mechamism of lung branching morphogenesis

    Takashi Miura

    2010.5 

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    Mechamism of lung branching morphogenesis

  • Roles of epithelium and mesenchyme during lung branching morphogenesis

    Takashi Miura

    2010.6 

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    Roles of epithelium and mesenchyme during lung branching morphogenesis

  • FGF-induced collective cell migration during lung branching morphogenesis

    Takashi Miura

    SDB-JSDB Joint Meeting in New Mexico  2010.8 

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  • Mechanism of lung branching morphogenesis

    Takashi Miura

    24th ALTENBERG WORKSHOP IN THEORETICAL BIOLOGY  2010.9 

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    Mechanism of lung branching morphogenesis

  • 発生における 形態形成のモデル化とその実験的検証

    三浦 岳

    明治大学集中講義  2010.11 

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  • in vitroでのVEGFの拡散係数計測

    吉村賢二, 三浦岳

    定量生物学の会  2010.11 

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  • 発生現象の数理モデル化とその実験的検証

    三浦 岳

    Potts model研究会  2010.12 

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  • Modeling lung branching morphogenesis in vitro

    Takashi Miura

    2011.1 

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  • Modeling lung branching morphogenesis via epithelial-mesenchymal interaction

    Takashi Miura

    2011.5 

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    Modeling lung branching morphogenesis via epithelial-mesenchymal interaction

  • 肺の枝分かれ構造の 形成機構

    三浦 岳

    京都駅前セミナー  2011.7 

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  • Modeling lung branching morphogenesis via epithelial-mesenchymal interaction

    Takashi Miura

    SDB annual meeting 2011  2011.7 

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    Modeling lung branching morphogenesis via epithelial-mesenchymal interaction

  • 上皮間葉間相互作用による 肺の枝分かれ構造形成

    三浦 岳

    数理生物学会  2011.9 

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  • Morphogen gradient

    2011.9 

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  • How well does Turing's theory of morphogenesis work?

    2011.11 

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    How well does Turing's theory of morphogenesis work?

  • Turing パターンにおけるパターンの精度と生成速度の関係

    平賀顕一, 三浦岳

    定量生物学の会  2012.1 

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  • 頭蓋骨縫合線のパターン形成の数理モデル

    吉村賢二, 三浦岳

    日本解剖学会  2012.3 

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  • フェーズフィールド法を用いた肺の枝分かれ構造形成のモデル化

    三浦 岳

    解剖学会  2012.3 

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  • 頭蓋骨縫合線のパターン形成:発生と数理をつなぐ

    三浦 岳

    Evo-Devo若手の会  2012.6 

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  • Visualizing morphogen diffusion dynamics during lung branching morphogenesis in vitro.

    Takashi Miura

    FASEB lung meeting  2012.7 

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    Visualizing morphogen diffusion dynamics during lung branching morphogenesis in vitro.

  • 頭蓋骨縫合線のパターン形成の 数理モデル化とその実験的検証 Invited

    三浦 岳

    植物学会  2012.9 

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  • 内皮細胞のメッシュワーク形成と VEGFの拡散ダイナミクス

    三浦 岳

    数理生物学会  2012.9 

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  • Visualizing Morphogen Diffusion Dynamics in lung branching morphogenesis

    Takashi Miura

    APDB conference  2012.10 

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    Visualizing Morphogen Diffusion Dynamics in lung branching morphogenesis

  • 生物の形づくりのモデリング:プロトタイピング言語としての Mathematica Invited

    三浦 岳

    2012.11 

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  • A novel mathematical model of endothelial cell dynamics during angiogenic morphogenesis: analysis of cell-based mechanisms

    2012.12 

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    A novel mathematical model of endothelial cell dynamics during angiogenic morphogenesis: analysis of cell-based mechanisms

  • A New Mathematical Model of Pattern Formation of the Cranial Suture

    2012.12 

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    A New Mathematical Model of Pattern Formation of the Cranial Suture

  • 頭蓋骨縫合線のパターン形成の 数理モデル化とその実験的検証

    三浦 岳, 吉村 賢二

    植物ミニシンポジウム  2013.1 

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    Venue:熊本   Country:Other  

  • 細胞壁と頭蓋骨 - パターン形成ダイナミクスの数理モデルによる統合的理解 Invited

    三浦 岳, 吉村 賢二

    植物細胞壁シンポジウム  2013.3 

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    Venue:仙台   Country:Other  

  • Cell Wall and Skull Bone:Understanding Pattern Formation Dynamics using Mathematical Model

    Takumi Higaki, Takashi Miura

    2013.5 

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    Mathematical model of epithelial buckling for single- and multi-step processes of the intestinal villus formation

  • 頭蓋骨縫合線のパターン形成の数理モデル Invited

    三浦 岳

    Craniosynostosis研究会  2013.7 

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    Venue:東京   Country:Other  

  • 肺の枝分れの形成機構とmorphogen の拡散動態

    三浦 岳

    CDBセミナー  2013.7 

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    Venue:神戸   Country:Other  

  • Modeling lung branching morphogenesis

    Takashi Miura

    2013.7 

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    Modeling vascular scaling law formation in retina vasculature

  • 発生における 自発的パターン形成

    三浦 岳

    細胞システムコロキウム  2013.9 

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    Venue:埼玉   Country:Other  

  • ショウジョウバエ神経発生におけるProneural waveの伝播現象

    三浦 岳, 長山 雅晴, 佐藤 純

    数理生物学会  2013.9 

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    Venue:静岡   Country:Other  

  • Mechanism of lung branching morphogenesis

    Takashi Miura

    2013.9 

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  • Mechanism of lung branching morphogenesis

    Takashi Miura

    2013.10 

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  • Mechanism of lung branching morphogenesis

    Takashi Miura

    2013.10 

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  • 細胞集団運動における振動現象

    三浦 岳

    時間生物学会  2013.11 

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    Venue:大阪   Country:Other  

  • 内皮細胞の自発的パターン形成 - ブレイクスルーを生むコラボレーション

    三浦 岳, 西山 功一

    発生生物学会秋季シンポジウム  2013.11 

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    Venue:大阪   Country:Other  

  • 発生における自発的パターン形成とmorphogen の拡散動態

    三浦 岳

    顕微鏡学会九州支部会  2013.12 

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    Venue:福岡   Country:Other  

  • Regulation of morphogen diffusion affects spontaneous pattern formation in development

    Takashi Miura

    2014.5 

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  • 肺の枝分れの形成機構 Invited

    三浦 岳

    分子病理学研究会宮城蔵王シンポジウム  2014.7 

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    Venue:仙台   Country:Other  

  • Morphogen diffusion and spontaneous pattern formation: from theory to practice

    Takashi Miura

    2014.8 

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  • 肺の枝分れ構造の形成機構 Invited

    三浦 岳

    佐島シンポジウム  2014.10 

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    Venue:京都   Country:Other  

  • Collective migration of lung epithelial cells during branching morphogenesis

    Takashi Miura

    2014.10 

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  • 生物の形作りとシミュレーション:分野間連携の実際 Invited

    三浦 岳

    NINSコロキウム  2014.12 

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    Venue:小田原   Country:Other  

  • 培養細胞のパターン形成

    三浦 岳

    岡山駅前セミナー  2014.12 

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    Venue:岡山   Country:Other  

  • 細胞運動と Delta-Notch の相互作用の解析

    小熊 俊輝, 三浦 岳

    定量生物学の会  2015.1 

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    Venue:福岡   Country:Other  

  • 生物のかたちづくりのモデリングの歴史:単純と複雑の循環 Invited

    三浦 岳

    定量生物学の会  2015.1 

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    Venue:福岡   Country:Other  

  • 血管網形成の数理モデル Invited

    三浦 岳

    次世代創薬シンポジウム  2015.3 

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  • Modeling Pattern formation during development_

    Takashi Miura

    2015.6 

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  • Mechanism of shortcut prevention during retinal blood vessel development Invited

    Atsushi Tero, Akiyoshi Uemura, Takashi Miura

    2015.6 

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    Perfusable synthetic self-organized vascular network - experiment and modeling

  • 縫合線パターンのフラクタル性の起源

    三浦 岳

    Craniosynostosis研究会  2015.7 

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    Venue:大阪   Country:Other  

  • Modeling endothelial capillary network formation in microdevice

    Takashi Miura

    2015.8 

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  • Mathematical Modeling of MDCK spontaneous movement

    Daiki Sasaki, Takashi Miura

    2015.8 

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  • Formation of fractal structure in skull suture

    Takashi Miura

    ICIAM  2015.8 

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  • 体外で機能する毛細血管網の形成 - モデリングによる理解と器官培養系への応用

    三浦 岳

    大阪母子センターセミナー  2015.9 

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    Venue:大阪   Country:Other  

  • Modeling vasculogenesis in perfusable 3D microvascular networks on a chip

    Takashi Miura

    Asia Pacific Developmental Biology Conference  2015.9 

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  • MDCK細胞の集団運動における細胞間相互作用

    三浦 岳

    応用数理学会  2015.9 

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    Venue:金沢   Country:Other  

  • 発生におけるマルチスケールの自発的パターン形成現象

    三浦 岳

    富山シンポジウム  2015.11 

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    Venue:富山   Country:Other  

  • 発生におけるマルチスケールのパターン形成現象

    三浦 岳

    数理研研究集会「現象解明に向けた数値解析学の新展開」  2015.11 

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  • 生物のかたちを数学で理解する Invited

    三浦 岳

    白石記念講座  2015.11 

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    Venue:東京   Country:Other  

  • Mechanism of epithelial pattern formation in development: experiment and modeling Invited

    Takashi Miura

    International Conference on Systems Biolofy  2015.11 

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  • Perfusable self-organized capillary network in a microdevice: modeling and applications

    Takashi Miura

    2015.12 

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  • 頭蓋骨縫合線のパターン形成とフラクタル性

    三浦 岳

    京都大学理学部  2016.2 

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    Venue:京都   Country:Other  

  • 体外で機能する毛細血管網の形成 - モデリングによる理解と器官培養系への応用

    三浦 岳

    解剖学会  2016.3 

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    Venue:福島   Country:Other  

  • Mechanism of Scaling law formation in developing retina vasculature structure

    Osamu Iizuka, Akiyoshi Uemura, Hiroshi Kori, Takashi Miura

    2016.6 

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    Country:Other  

  • Mathematical analysis of fractality of skull sutures

    Yuto Naroda, Yoshinaga Kajimoto, Kenji Yoshimura, Takashi Miura

    2016.6 

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    Mechanism of scaling law formation in retina vasculature - modeling and experiment

  • 血管網形成の数理モデルと実験的検証 Invited

    三浦 岳

    生物リズム若手の会  2016.9 

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    Venue:山口   Country:Other  

  • The effect of cell dynamics on Delta-Notch pattern formation during retinal angiogenesis

    Toshiki Oguma, Tomoharu Shinoda, Shuntaro Ogura, Akiyoshi Uemura, Takaki Miyata, Takashi Miura

    2016.9 

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    Modeling of skull suture pattern formation

  • Modeling pattern formation of skull suture interdigitation

    Takashi Miura

    Mathematics of Pattern Formation  2016.9 

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    Mechanism of skull suture pattern formation

  • Mechanism of jigsaw-puzzle pattern formation in plant leaf epidermal cell: modeling single cell shape by interface equation and convolution kernel

    Takashi Miura, Takumi Higaki, Natsumaro Kutsuna, Kae Akita, Hisako Takigawa-Imamura, Kenji Yoshimura

    2016.9 

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  • Mechanism of Scaling law formation in developing retina vasculature

    Osamu Iizuka, Akiyoshi Uemura, Takashi Miura

    2016.9 

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  • Mathematical analysis of fractality of skull sutures

    Yuto Naroda, Kenji Yoshimura, Yoshinaga Kajimoto, Tomohisa Ohmura, Takashi Miura

    2016.9 

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    Distribution pattern of immune cells - quantification and mathematical modeling of pattern formation mechanism

  • Mathematical analysis of fractality of skull sutures

    Yuto Naroda, Kenji Yoshimura, Yoshinaga Kajimoto, Tomohisa Ohmura, Takashi Miura

    2016.9 

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  • 頭蓋骨縫合線のパターン形成

    三浦 岳

    六甲医学研究会  2016.10 

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    Venue:淡路島   Country:Other  

  • 灌流可能な自己組織化血管網

    三浦 岳

    金沢大学先魁プロジェクト  2016.11 

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    Venue:金沢   Country:Other  

  • Vascular pattern formation: experiment, theory and reconstruction

    Takashi Miura

    2016.11 

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  • 反応拡散系を用いた自発的パターン形成の数理モデル化

    三浦 岳

    京都大学医学部皮膚科  2016.12 

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    Venue:京都   Country:Other  

  • Modeling vascular pattern formation in retina vasculature

    Takashi Miura

    2016.12 

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  • Mechanism of jigsaw-puzzle pattern formation in plant leaf epidermal cell

    Takashi Miura

    2016.12 

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  • 細胞壁と頭蓋骨 - 数理モデルによる 自発的パターン形成メカニズムの解明

    三浦岳

    基礎生物学研究所セミナー  2017.1 

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    Venue:岡崎   Country:Other  

  • 血管内皮細胞による自律的なパターン形成の数理

    ◯中益朗子,出原浩史,新宮直人,三浦岳

    第4回JST数学領域横断若手合宿  2017.2 

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    Venue:香川   Country:Other  

  • 血管内皮細胞が自律的に形成するパターンサイズに対する数理解析

    発生生物学会  2017.5 

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    Venue:東京   Country:Other  

  • 網膜血管網におけるスケーリング則の形成メカニズム

    発生生物学会  2017.5 

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    Venue:東京   Country:Other  

  • 生物の形づくりの数理 -Mathematicaによるrapid prototyping- Invited

    三浦 岳

    2017.6 

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    Venue:福岡   Country:Other  

  • 精細管における wavetrain パターン形成のモデリング

    河村真理, 杉原圭, 三浦岳

    数理生物学会  2017.10 

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    Venue:札幌   Country:Other  

  • 人工血管網形成の数理モデル

    佐々木大貴, 三浦岳

    数理生物学会  2017.10 

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    Venue:札幌   Country:Other  

  • Skull suture and plant cell wall: Mechanism of interdigitation pattern formation

    2017.10 

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    Skull suture and plant cell wall: Mechanism of interdigitation pattern formation

  • Mechanism of scaling law formation in retina vasculature - modeling and experiment

    Osamu Iizuka, Shotaro Kawamura, Akiyoshi Uemura, Takashi Miura

    2017.10 

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    Mechanism of scaling law formation in retina vasculature - modeling and experiment

  • FGFとWntの協同による肺分岐のヒエラルキー構造形成

    今村(滝川)寿子, 麓勝己, 三浦岳

    数理生物学会  2017.10 

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    Venue:札幌   Country:Other  

  • A Mathematical model to generate fractal structure in skull suture

    Yuto Naroda, Yoshie Endo, Kenji Yoshimura, Takashi Miura

    2017.10 

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    A Mathematical model to generate fractal structure in skull suture

  • Mechanism of skull suture pattern formation

    IWOMB2018 (Cebu)  2018.1 

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    Mechanism of skull suture pattern formation

  • 植物細胞壁の湾曲構造形成の 理論モデル

    三浦岳 桧垣匠

    AIMaP「反応拡散系と実験の融合」  2018.2 

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    Venue:金沢   Country:Other  

  • Pericyte coverage of endothelial cells: in vitro experiments and computational modeling.

    Kei Sugihara, Saori Sasaki, Akiyoshi Uemura, Satoru Kidoaki, Takashi Miura

    2018.6 

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    Pericyte coverage of endothelial cells: in vitro experiments and computational modeling.

  • 血の通った培養系: マイクロ流体デバイスと 自己組織化血管網の融合

    三浦 岳

    細胞凝集研究会  2018.7 

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    Venue:酒田   Country:Other  

  • 細胞壁と頭蓋骨: 分野を超える数理 Invited

    三浦岳

    生物数学の理論とその応用  2018.9 

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    Venue:京都   Country:Other  

  • Modeling of skull suture pattern formation

    2018.9 

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    Modeling of skull suture pattern formation

  • Distribution pattern of immune cells - quantification and mathematical modeling of pattern formation mechanism

    2018.9 

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    Distribution pattern of immune cells - quantification and mathematical modeling of pattern formation mechanism

  • Establishment of perfusable vascular network for understanding multicellular pattern formation

    2018.11 

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    Establishment of perfusable vascular network for understanding multicellular pattern formation

  • 肺の枝分れの形成機構 - 数理モデリングによる理解 Invited

    三浦 岳

    呼吸器イメージング学会  2019.1 

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    Venue:東京   Country:Other  

  • 頭蓋骨縫合線のパターン形成

    三浦 岳

    反応拡散系 のパターン形成とその応用  2019.2 

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    Venue:岡山   Country:Other  

  • 口蓋縫合のパターン形成の数理モデル

    澁澤伸英, 三浦岳

    日本解剖学会  2019.3 

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    Venue:新潟   Country:Other  

  • 頭蓋骨縫合線の形成機構

    三浦 岳

    第2回松江数理生物学・現象数理学ワークショップ  2019.8 

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    Venue:島根   Country:Other  

  • 血管網のパターン形成:数理モデリングと再構成による検証 Invited

    三浦 岳

    数理シグナル若手の会  2019.9 

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    Venue:愛媛   Country:Other  

  • 細胞集団運動における周期的突起形成のメカニズム

    小熊俊輝, 今村寿子, 三浦岳

    日本数理生物学会年会  2019.9 

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  • 小腸粘膜の三次元構造は上皮細胞をムラなく脱落させる

    甲斐悠斗, 三浦岳

    数理生物学会  2019.9 

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    Venue:東京   Country:Other  

  • Perfusable synthetic self-organized vascular network - experiment and modeling Invited

    International Conference of Systems Biology  2019.11 

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    Perfusable synthetic self-organized vascular network - experiment and modeling

  • 上皮細胞シートにおけるフラクタル構造形成のメカニズム

    小熊 俊輝, 今村 寿子, 三浦 岳

    第16回 生物数学の理論とその応用 -生命現象の定量的理解に向けて  2020.1 

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  • ペリサイトが血管分岐部を選好するメカニズムの探索

    杉原圭, 植村明嘉, 三浦岳

    日本数理生物学会  2020.9 

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  • 頭蓋骨縫合線のパターン形成機構 Invited

    三浦 岳

    東京医科歯科大学 数理生物学セミナー2020  2020.11 

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  • 血管網のパターン形成:実験、数理モデリングと再構成

    三浦岳

    北大MMCセミナー  2021.1 

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  • Self-organized perfusable capillary network in vitro: Experiment and modeling

    Takashi Miura

    Synthetic Morphogenesis: From Gene Circuits to Tissue Architecture  2021.3 

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MISC

  • マイクロ流体デバイスを用いた血管網に対するペリサイトの影響の評価

    寺岡佑佳子, ERICKSON Scott, 梨本裕司, 新宅博文, 小寺秀俊, 横川隆司, 中益朗子, 三浦岳, 有馬勇一郎, 花田三四郎, 西山功一

    電気学会全国大会講演論文集(CD-ROM)   2018.3

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  • オンチップ血管網での剪断応力知覚による血管新生の評価

    寺岡佑佳子, 中山雅宗, 梨本裕司, 中益朗子, 花田三四郎, 有馬勇一郎, 鳥澤勇介, 新宅博文, 小寺秀俊, 西山功一, 三浦岳, 横川隆司

    バイオエンジニアリング講演会講演論文集(CD-ROM)   2017.12

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  • 灌流可能な血管を有するオンチップ腫瘍モデルの創出

    梨本裕司, 寺岡佑佳子, 有馬勇一朗, 花田三四郎, 中益朗子, 鳥澤勇介, 小寺秀俊, 西山功一, 三浦岳, 横川隆司

    センサ・マイクロマシンと応用システムシンポジウム(CD-ROM)   2017.10

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  • 3D血管網を用いた剪断応力の知覚と伝達による血管新生評価システム

    寺岡佑佳子, 中山雅宗, 梨本裕司, 中益朗子, 花田三四郎, 有馬勇一郎, 鳥澤勇介, 新宅博文, 小寺秀俊, 西山功一, 三浦岳, 横川隆司

    センサ・マイクロマシンと応用システムシンポジウム(CD-ROM)   2017.10

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  • Remodeling in synthetic vascular network - experiment and modeling Reviewed

    Takashi Miura, Nobuyuki Futai, Daiki Sasaki, Yuji Nashimoto, Ryuji Yokokawa, Kimiko Yamamoto, Shin Koide

    MECHANISMS OF DEVELOPMENT   2017.7

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    Remodeling in synthetic vascular network - experiment and modeling

    DOI: 10.1016/j.mod.2017.04.059

  • Development of three-dimensional tumor model with a perfusable vasculature using a microfluidic device Reviewed

    Yuji Nashimoto, Yukako Teraoka, Yuichiro Arima, Akiko Nakamasu, Yu-suke Torisawa, Hidetoshi Kotera, Koichi Nishiyama, Takashi Miura, Ryuji Yokokawa

    MECHANISMS OF DEVELOPMENT   2017.7

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    Development of three-dimensional tumor model with a perfusable vasculature using a microfluidic device

    DOI: 10.1016/j.mod.2017.04.041

  • Reconstitutive analyses of impacts of pericytes and blood flow on angiogenic morphogenesis using a microfluidic device Reviewed

    Koichi Nishiyama, Yuichiro Arima, Shigetomo Fukuhara, Yoshimi Yamaguchi, Michie Uchikawa, Yuji Nashimoto, Akiko Nakamasu, Ryuji Yokokawa, Takashi Miura

    MECHANISMS OF DEVELOPMENT   2017.7

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    Reconstitutive analyses of impacts of pericytes and blood flow on angiogenic morphogenesis using a microfluidic device

    DOI: 10.1016/j.mod.2017.04.158

  • 第32回研究会優秀研究賞 血管新生現象を利用した組織 : マイクロ流路間の接続と灌流培養への取り組み

    梨本 裕司, 國田 樹, 中益 朗子, 鳥澤 勇介, 中山 雅宗, 今村(滝川) 寿子, 小寺 秀俊, 西山 功一, 三浦 岳, 横川 隆司

    化学とマイクロ・ナノシステム = Journal of the Society for Chemistry and Micro-Nano Systems : 化学とマイクロ・ナノシステム研究会誌   2016.3

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  • 発生における細胞外シグナル因子の拡散ダイナミクス (生物現象に対するモデリングの数理)

    三浦 岳

    数理解析研究所講究録   2012.4

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  • 発生生物学におけるチューリング系の応用--四肢骨格のパターン形成を例として (特集 数理生物学)

    三浦 岳

    蛋白質核酸酵素   2005.12

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  • 発生生物学における Turing 系の応用 - 四肢骨格のパターン形成を例として

    三浦 岳

    蛋白質核酸酵素   2005.12

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    生物の発生段階において、自発的なパターン形成によって周期構造が生じる事がある。数理生物学の分野ではこの現象をモデル化する際に Turing の反応拡散系が広く使われているが、発生生物学での応用例はま だ少ない。我々は四肢の骨格のパターン形成に関して Turing 系を応用 する試みをしているが、これによって実験的に進歩した部分、理論的に 進歩した部分をそれぞれ紹介し、数理生物学との相互作用による利点や 将来の展望について論じる。

    Repository Public URL: http://hdl.handle.net/2324/4751312

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Professional Memberships

  • 発生生物学会

  • 解剖学会

  • 先天異常学会

  • Society for Developmental Biologists

  • 数理生物学会

  • Japanese Society for Mathematical Biologists

  • 生物物理学会

  • 先天異常学会

  • 発生生物学会

  • 解剖学会

  • 生化学会

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Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:9

  • Screening of academic papers

    Role(s): Peer review

    2019

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:9

  • Screening of academic papers

    Role(s): Peer review

    2018

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:10

  • Screening of academic papers

    Role(s): Peer review

    2017

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:8

  • その他

    日本数理生物学会  ( 九州大学 Japan ) 2016.9

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  • Screening of academic papers

    Role(s): Peer review

    2016

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:7

  • Screening of academic papers

    Role(s): Peer review

    2015

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:11

  • Screening of academic papers

    Role(s): Peer review

    2014

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:8

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Research Projects

  • スケーリング則を持つ脊椎動物組織のパターン形成機構の数理モデル化と実験的検証

    Grant number:24K02036  2024 - 2027

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 植物オルガネラの統合的フェノーム解析技術の研究

    Grant number:16K18562  2016 - 2018

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 網膜新生血管における内皮細胞ダイナミクスの解析

    Grant number:16K15737  2016 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 発生におけるマルチスケールの自発的パターン形成現象の数理の解明

    Grant number:15KT0018  2015 - 2018

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Grant type:Scientific research funding

  • 葉表皮細胞の人為的変形系を用いた細胞形態および細胞間信号伝達シミュレーション解析

    Grant number:15K14536  2015 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • からだの外でかたちを育てる

    2014 - 2019

    CREST

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    Authorship:Principal investigator  Grant type:Contract research

  • 植物表皮細胞壁のジグソーパズル構造形成メカニズム

    Grant number:26520207  2014 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 自己組織化を利用したオンチップ血管モデルの開発―血管生理・病態の再現と理解

    Grant number:26670394  2014 - 2015

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 発生に於けるパターン形成現象の数理モデル化

    2014

    上原記念財団研究推進特別奨励金

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    Authorship:Principal investigator  Grant type:Contract research

  • 形態形成理解のためのマルチスケールマウス初期胚培養デバイス

    Grant number:25600060  2013 - 2015

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • RhoJによる内皮細胞運動と血管網パターン形成の制御機構

    Grant number:25293078  2013 - 2015

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 肺上皮の集団運動のメカニズムとmorphogen gradient

    Grant number:25111713  2013 - 2014

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

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    Grant type:Scientific research funding

  • 被毛パターン変異ラットを用いた反応拡散モデル実証のための実験モデル系の創出

    Grant number:25640046  2013 - 2014

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 血管網を作る - 内皮細胞の自己組織化現象の実験と理論による解明

    Grant number:25127708  2013 - 2014

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

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    Grant type:Scientific research funding

  • 発生に於けるパターン形成現象の 数理モデル化

    2013

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 細胞骨格の制御を介した細胞外情報処理機構の解明

    Grant number:24114007  2012 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 生物の形作りの数理的記述法の確立

    Grant number:23654036  2011 - 2012

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 肺の枝分かれ構造形成における細胞集団運動のメカニズムの解明

    Grant number:23111514  2011 - 2012

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 生理学と協働した数理科学による皮膚疾患機構の解明

    2010.4 - 2015.3

    北海道大学 

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

  • 発生過程の関節軟骨の力学特性とリハビリテーションの基礎的研究

    Grant number:22700532  2010 - 2012

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 頭蓋骨縫合線のパターン形成の数理モデル化とその実験的検証

    Grant number:22659035  2010 - 2012

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 前脳形態形成におけるシグナル分子の役割の解明

    Grant number:20590169  2008 - 2010

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • モルフォゲンの濃度勾配ロバストネス保証および分化運命決定における閾値の分子機構

    Grant number:20022020  2008 - 2009

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 生物における構造形成と情報に関する数理的研究

    Grant number:19340023  2007 - 2010

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 上皮組織のかたちづくりを理解する

    2007 - 2010

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 前脳形態形成分子機構の解明

    Grant number:18590168  2006 - 2007

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 哺乳動物の発生過程における自発的パターン形成現象の数理モデル化とその実験的検証

    Grant number:17689009  2005 - 2007

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 内耳原基の器官培養系を用いた内耳の形態形成機構と内耳奇形発生のメカニズムの解明

    Grant number:14657005  2002 - 2004

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • マウス胎児肢芽細胞の微少集積培養系におけるパターン形成メカニズムの解明

    Grant number:13770010  2001 - 2002

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 胎児の肺原基における初期分枝パターンの数理モデル化とその実験的検証

    Grant number:12877003  2000 - 2001

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 哺乳類の形態形成現象に関与する分子の三次元的定量とその数理モデル化の研究

    Grant number:97J03294  1998 - 1999

    日本学術振興会  科学研究費助成事業  特別研究員奨励費

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    Authorship:Principal investigator  Grant type:Scientific research funding

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Educational Activities

  • Cell Biology
    Human Anatomy
    Histology

Class subject

  • 発生生物学

    2023.10 - 2024.3   Second semester

  • 細胞生物学

    2023.4 - 2023.9   First semester

  • 人体解剖学概論

    2023.4 - 2023.9   First semester

  • 組織学

    2023.4 - 2023.9   First semester

  • 人体構造概論

    2023.4 - 2023.9   First semester

  • 発生生物学

    2022.10 - 2023.3   Second semester

  • 細胞生物学

    2022.4 - 2022.9   First semester

  • 人体解剖学概論

    2022.4 - 2022.9   First semester

  • 組織学

    2022.4 - 2022.9   First semester

  • 人体構造概論

    2022.4 - 2022.9   First semester

  • 発生生物学

    2021.10 - 2022.3   Second semester

  • 組織学

    2021.4 - 2021.9   First semester

  • 人体構造概論

    2021.4 - 2021.9   First semester

  • 人体解剖学概論

    2021.4 - 2021.9   First semester

  • 細胞生物学

    2021.4 - 2021.9   First semester

  • 発生生物学

    2020.10 - 2021.3   Second semester

  • 細胞生物学

    2020.4 - 2020.9   First semester

  • 人体構造概論

    2020.4 - 2020.9   First semester

  • 組織学

    2020.4 - 2020.9   First semester

  • 人体解剖学概論

    2020.4 - 2020.9   First semester

  • 発生生物学

    2019.10 - 2020.3   Second semester

  • 人体解剖学概論

    2019.4 - 2019.9   First semester

  • 人体構造概論

    2019.4 - 2019.9   First semester

  • 組織学

    2019.4 - 2019.9   First semester

  • 発生生物学

    2018.10 - 2019.3   Second semester

  • 人体解剖学概論

    2018.4 - 2018.9   First semester

  • 人体構造概論

    2018.4 - 2018.9   First semester

  • 組織学

    2018.4 - 2018.9   First semester

  • 生命の科学A

    2018.4 - 2018.6   Spring quarter

  • 発生生物学

    2017.10 - 2018.3   Second semester

  • 数理医学

    2017.10 - 2017.12   Fall quarter

  • 人体解剖学概論

    2017.4 - 2017.9   First semester

  • 人体構造概論

    2017.4 - 2017.9   First semester

  • 組織学

    2017.4 - 2017.9   First semester

  • 発生生物学

    2016.10 - 2017.3   Second semester

  • 人体解剖学概論

    2016.4 - 2016.9   First semester

  • 人体構造概論

    2016.4 - 2016.9   First semester

  • 組織学

    2016.4 - 2016.9   First semester

  • 発生生物学

    2015.10 - 2016.3   Second semester

  • 人体解剖学概論

    2015.4 - 2015.9   First semester

  • 人体構造概論

    2015.4 - 2015.9   First semester

  • 組織学

    2015.4 - 2015.9   First semester

  • 人体解剖学概論

    2014.4 - 2014.9   First semester

  • 人体構造概論

    2014.4 - 2014.9   First semester

  • 組織学

    2014.4 - 2014.9   First semester

  • 発生生物学

    2014.4 - 2014.9   First semester

  • 人体構造概論

    2013.10 - 2014.3   Second semester

  • 人体解剖学概論

    2013.4 - 2013.9   First semester

  • 組織学

    2013.4 - 2013.9   First semester

  • 人体構造と機能I

    2013.4 - 2013.9   First semester

  • 人体構造学概論

    2013.4 - 2013.9   First semester

  • 発生生物学

    2013.4 - 2013.9   First semester

  • 組織学

    2013.4 - 2013.9   First semester

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FD Participation

  • 2015.12   Role:Participation   Title:H27年度大学院FD

    Organizer:[Undergraduate school/graduate school/graduate faculty]

Other educational activity and Special note

  • 2023  Coaching of Students' Association 

  • 2023  Coaching of Students' Association 

  • 2022  Coaching of Students' Association 

  • 2022  Coaching of Students' Association 

  • 2020  Coaching of Students' Association 

  • 2020  Coaching of Students' Association 

  • 2019  Coaching of Students' Association 

  • 2019  Coaching of Students' Association 

  • 2018  Coaching of Students' Association 

  • 2018  Coaching of Students' Association 

  • 2017  Coaching of Students' Association 

  • 2017  Coaching of Students' Association 

  • 2016  Coaching of Students' Association 

  • 2016  Coaching of Students' Association 

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Media Coverage

  • 九大、毛細血管網を手軽に作製 生体外で生物学的な機能

    2020.10

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    九大、毛細血管網を手軽に作製 生体外で生物学的な機能

  • 九州大、細胞が細胞を包む仕組みは何か?―血管における細胞の形作りに数学で迫る―

    2020.2

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    九州大、細胞が細胞を包む仕組みは何か?―血管における細胞の形作りに数学で迫る―

  • NHKスペシャル「人体」

    2017.10

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    NHKスペシャル「人体」

  • 京大と九大と熊本大、培養組織の中に毛細血管状の管を通し栄養や酸素を供給できるマイクロ流体デバイスを開発

    2017.6

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    京大と九大と熊本大、培養組織の中に毛細血管状の管を通し栄養や酸素を供給できるマイクロ流体デバイスを開発

  • 臓器につなげる血管網の作製器具「マイクロ流体デバイス」開発 京大など共同チーム…再生医療技術で普及期待

    2017.6

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    臓器につなげる血管網の作製器具「マイクロ流体デバイス」開発 京大など共同チーム…再生医療技術で普及期待

  • 世界初、植物細胞の形の謎を解明 鍵は頭蓋骨縫合線と数学 九州大学ほか

    2016.4

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    世界初、植物細胞の形の謎を解明 鍵は頭蓋骨縫合線と数学 九州大学ほか

  • Turing vs. Wolpert - 反応拡散系に寄るパターン形成の応用研究の系譜 Newspaper, magazine

    現代思想Vol40-14  2012.10

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    Turing vs. Wolpert - 反応拡散系に寄るパターン形成の応用研究の系譜

  • シリーズ細胞の世界(1)体を作る不思議な「波」 TV or radio program

    サイエンスゼロ  2011.4

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    シリーズ細胞の世界(1)体を作る不思議な「波」

  • サイエンスZERO シリーズ細胞の世界1 体をつくる不思議な"波”~

    2011.4

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    サイエンスZERO シリーズ細胞の世界1 体をつくる不思議な"波”~

  • 動物たちの模様を解く魔法の数式 天才数学者が残した遺産

    2004.2

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    動物たちの模様を解く魔法の数式 天才数学者が残した遺産

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Travel Abroad

  • 2011.12

    Staying countory name 1:Spain   Staying institution name 1:Univ Compultense de Madrid

    Staying countory name 2:Germany   Staying institution name 2:EMBL Heidelberg

  • 2002.7 - 2004.6

    Staying countory name 1:United Kingdom   Staying institution name 1:Oxford University

    Staying countory name 2:Germany   Staying institution name 2:Heidelberg University