Updated on 2025/06/26

Information

 

写真a

 
NINOMIYA TOSHIHARU
 
Organization
Faculty of Medical Sciences Department of Basic Medicine Professor
Faculty of Medical Sciences Center for Cohort Studies(Concurrent)
School of Dentistry Department of Dentistry(Concurrent)
Graduate School of Medical Sciences Department of Health Care Administration and Management(Concurrent)
Graduate School of Medical Sciences Department of Medicine(Concurrent)
School of Medicine Department of Medicine(Concurrent)
Title
Professor
Tel
0926426151
Profile
研究活動:久山町における疫学調査(久山町研究)で、認知症・高血圧・脳卒中・虚血性心疾患・慢性腎臓病などの発症率、危険因子についての検討する。更に、国内の大規模認知症コホート研究を主導する。認知症や心血管病、慢性腎臓病や高血圧に関する国際共同研究に参加する。また、久山町研究のデータ解析や福岡市のデータベース解析を通じ、福岡県や福岡市、久山町の公衆衛生活動を支援する。 教育活動:医学部4年生、6年生および大学院生に対し講義、研究指導を行う。
External link

Research Areas

  • Life Science / Hygiene and public health

  • Life Science / Hygiene and public health

  • Life Science / Nephrology

  • Life Science / Psychiatry

  • Life Science / Nutrition science and health science

  • Life Science / Cardiology

  • Life Science / Medical management and medical sociology

  • Life Science / Medical management and medical sociology

  • Life Science / General internal medicine

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Degree

  • Ph.D. (Dr. of Medical Science) Faculty of Medicine, Kyushu University

Research History

  • Kyushu University Faculty of Medical Sciences Professor 

    2016.6 - Present

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  • Kyushu University Faculty of Medical Sciences 教授(兼任) 

    2014.5 - Present

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Education

  • Kyushu University   大学院医学系研究科内科系専攻博士課程  

    1996.4 - 2000.3

  • Kyushu University   医学部  

    - 1993.3

Research Interests・Research Keywords

  • Research theme: 身体組成

    Keyword: 身体組成

    Research period: 2025

  • Research theme: 認知症

    Keyword: 認知症

    Research period: 2025

  • Research theme: 虚血性心疾患

    Keyword: 虚血性心疾患

    Research period: 2025

  • Research theme: 腎臓学

    Keyword: 腎臓学

    Research period: 2025

  • Research theme: 脳卒中

    Keyword: 脳卒中

    Research period: 2025

  • Research theme: 脈波伝播速度

    Keyword: 脈波伝播速度

    Research period: 2025

  • Research theme: 総死亡

    Keyword: 総死亡

    Research period: 2025

  • Research theme: 系球体濾過値

    Keyword: 系球体濾過値

    Research period: 2025

  • Research theme: 糸球体濾過値

    Keyword: 糸球体濾過値

    Research period: 2025

  • Research theme: 疫学

    Keyword: 疫学

    Research period: 2025

  • Research theme: 死亡

    Keyword: 死亡

    Research period: 2025

  • Research theme: 時代的推移

    Keyword: 時代的推移

    Research period: 2025

  • Research theme: 時代的変化

    Keyword: 時代的変化

    Research period: 2025

  • Research theme: 心血管病発症

    Keyword: 心血管病発症

    Research period: 2025

  • Research theme: 心血管病

    Keyword: 心血管病

    Research period: 2025

  • Research theme: 心臓病

    Keyword: 心臓病

    Research period: 2025

  • Research theme: 地域住民

    Keyword: 地域住民

    Research period: 2025

  • Research theme: 地域一般高齢者

    Keyword: 地域一般高齢者

    Research period: 2025

  • Research theme: 危険因子

    Keyword: 危険因子

    Research period: 2025

  • Research theme: 動脈硬化

    Keyword: 動脈硬化

    Research period: 2025

  • Research theme: 前向き研究

    Keyword: 前向き研究

    Research period: 2025

  • Research theme: 久山町研究

    Keyword: 久山町研究

    Research period: 2025

  • Research theme: 一般住民

    Keyword: 一般住民

    Research period: 2025

  • Research theme: シスタチンC

    Keyword: シスタチンC

    Research period: 2025

  • Research theme: コホート研究

    Keyword: コホート研究

    Research period: 2025

  • Research theme: アルブミン尿

    Keyword: アルブミン尿

    Research period: 2025

  • Research theme: うつ病

    Keyword: うつ病

    Research period: 2025

  • Research theme: ADL障害

    Keyword: ADL障害

    Research period: 2025

  • Research theme: Epidemiology for dementia

    Keyword: Dementia

    Research period: 2010.9

  • Research theme: Chronic kidney disease and Cardiovascular disease

    Keyword: Chronic kidney disease

    Research period: 2010.9

  • Research theme: The identification of risk factors for cardiovascular disease

    Keyword: Cardiovascular disease

    Research period: 2010.9

  • Research theme: Epidemiology for diabetic nephropathy

    Keyword: Diabetic nephropathy

    Research period: 2010.5 - 2012.3

Awards

  • 井村臨床研究奨励賞(第7回)

    2010.9   財団法人 成人血管病研究振興財団   慢性腎臓病と心血管病の関係

  • Young Investigator Award 2010 for ISN Nexus Symposium Kyoto 2010.

    2010.4   International society of nephrology   The fixed combination of perindopril and indapamide has a greater effect on cardiovascular outcomes in patients with type 2 diabetes and albuminuria.

  • ISH Visiting Postdoctoral Award 2007-2008

    2008.1   Foundation for High Blood Pressure Research   Blood pressure and chronic kidney disease

  • ISH Visiting Postdoctoral Award 2007

    2007.1   Foundation for High Blood Pressure Research   Blood pressure and chronic kidney disease

  • Over Sea Presentation Course of Japan Society of Nephrology and Baxter Joint Scholarship Program

    2004.5   日本腎臓学会   Chronic kidney disease and Cardiovascular disease in a genral Japanese population: the Hisayama Study

Papers

  • Midlife and Late-Life Blood Pressure and Dementia in Japanese Elderly: The Hisayama Study. Reviewed International journal

    Ninomiya T, Ohara T, Hirakawa Y, Yoshida D, Doi Y, Hata J, Kanba S, Iwaki T, Kiyohara Y.

    Hypertension   58   2011.7

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Lower estimated glomerular filtration rate and higher albuminuria are associated with all-cause and cardiovascular mortality. A collaborative meta-analysis of high-risk population cohorts. Reviewed International journal

    van der Velde M, Matsushita K, Coresh J, Astor BC, Woodward M, Levey A, de Jong P, Gansevoort RT; the Chronic Kidney Disease Prognosis Consortium, van der Velde M, Matsushita K, Coresh J, Astor BC, Woodward M, Levey AS, de Jong PE, Gansevoort RT, Levey A, El-Nahas M, Eckardt KU, Kasiske BL, Ninomiya T, et al.

    Kidney Int   79   2011.6

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Apolipoprotein Genotype for Prediction of Alzheimer’s Disease in Older Japanese: The Hisayama Study. Reviewed International journal

    Ohara T, Ninomiya T, Kubo M, Hirakawa Y, Doi Y, Hata J, Iwaki T, Kanba S, Kiyohara Y.

    J Am Geriatr Soc   59   2011.6

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  • Albuminuria as a Risk Factor for Peripheral Arterial Disease in a General Population. Reviewed International journal

    Usui T, Ninomiya T, Nagata M, Doi Y, Hata J, Fukuhara M, Kiyohara Y.

    J Atheroscler Thromb   18   2011.5

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  • Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes in both general and high-risk populations. A collaborative meta-analysis of general and high-risk population cohorts. Reviewed International journal

    Gansevoort RT, Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, Jong PE, Coresh J; The Chronic Kidney Disease Prognosis Consortium, Gansevoort RT, Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, de Jong PE, Coresh J, El-Nahas M, Eckardt KU, Kasiske BL, Ninomiya T, Chalmers J, et al.

    Kidney Int   (in press)   2011.1

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  • The effects of blood pressure reduction and of different blood pressure-lowering regimens on major cardiovascular events according to baseline blood pressure: meta-analysis of randomized trials. Reviewed International journal

    Czernichow S, Zanchetti A, Turnbull F, Barzi F, Ninomiya T, Kengne AP, Lambers Heerspink HJ, Perkovic V, Huxley R, Arima H, Patel A, Chalmers J, Woodward M, Macmahon S, Neal B; on behalf of the Blood Pressure Lowering Treatment Trialists? Collaboration.

    J Hypertens   29   2011.1

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  • Severe hypoglycemia and risks of vascular events and death. Reviewed International journal

    Zoungas S, Patel A, Chalmers J, de Galan BE, Li Q, Billot L, Woodward M, Ninomiya T, Neal B, MacMahon S, Grobbee DE, Kengne AP, Marre M, Heller S; ADVANCE Collaborative Group.

    N Engl J Med   363   2010.1

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  • Impact of blood pressure lowering on cardiovascular outcomes in normal weight, overweight, and obese individuals: the Perindopril Protection Against Recurrent Stroke Study trial. Reviewed International journal

    Czernichow S, Ninomiya T, Huxley R, Kengne AP, Batty GD, Grobbee DE, Woodward M, Neal B, Chalmers J.

    Hypertension   55   2010.1

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  • Effects of a fixed combination of perindopril and indapamide in patients with type 2 diabetes and chronic kidney disease. Reviewed International journal

    Heerspink HJ, Ninomiya T, Perkovic V, Woodward M, Zoungas S, Cass A, Cooper M, Grobbee DE, Mancia G, Mogensen CE, Neal B, Chalmers J; ADVANCE Collaborative Group.

    Eur Heart J   31   2010.1

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  • Aspirin is beneficial in hypertensive patients with chronic kidney disease: a post-hoc subgroup analysis of a randomized controlled trial. Reviewed International journal

    Jardine MJ, Ninomiya T, Perkovic V, Cass A, Turnbull F, Gallagher MP, Zoungas S, Lambers Heerspink HJ, Chalmers J, Zanchetti A.

    J Am Coll Cardiol   56   2010.1

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  • Intensities of renal replacement therapy in acute kidney injury: a systematic review and meta-analysis. Reviewed International journal

    Jun M, Heerspink HJ, Ninomiya T, Gallagher M, Bellomo R, Myburgh J, Finfer S, Palevsky PM, Kellum JA, Perkovic V, Cass A.

    Clin J Am Soc Nephrol   5   2010.1

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  • Trends in the prevalence of chronic kidney disease and its risk factors in a general Japanese population: the Hisayama Study. Reviewed International journal

    Nagata M, Ninomiya T, Doi Y, Yonemoto K, Kubo M, Hata J, Tsuruya K, Iida M, Kiyohara Y.

    Nephrol Dial Transplant   25   2010.1

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  • Association of kidney function with coronary atherosclerosis and calcification in autopsy samples from Japanese elders: the Hisayama study. Reviewed International journal

    Nakano T, Ninomiya T, Sumiyoshi S, Fujii H, Doi Y, Hirakata H, Tsuruya K, Iida M, Kiyohara Y, Sueishi K.

    Am J Kidney Dis   55   2010.1

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  • Efficacy and safety of routine blood pressure lowering in older patients with diabetes: results from the ADVANCE trial. Reviewed International journal

    Ninomiya T, Zoungas S, Neal B, Woodward M, Patel A, Perkovic V, Cass A, Cooper M, Grobbee D, Hamet P, Harrap S, Liu L, Mancia G, Mogensen CE, Poulter N, Rodgers A, Williams B, MacMahon S, Chalmers J; ADVANCE Collaborative Group.

    J Hypertens   28   2010.1

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  • Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community: the Hisayama Study. Reviewed International journal

    Sekita A, Ninomiya T, Tanizaki Y, Doi Y, Hata J, Yonemoto K, Arima H, Sasaki K, Iida M, Iwaki T, Kanba S, Kiyohara Y.

    Acta Psychiatr Scand   122   2010.1

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  • Lowering blood pressure reduces renal events in type 2 diabetes. Reviewed International journal

    de Galan BE, Perkovic V, Ninomiya T, Pillai A, Patel A, Cass A, Neal B, Poulter N, Harrap S, Mogensen CE, Cooper M, Marre M, Williams B, Hamet P, Mancia G, Woodward M, Glasziou P, Grobbee DE, MacMahon S, Chalmers J; ADVANCE Collaborative Group.

    J Am Soc Nephrol   20   2009.1

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  • Proposed criteria for metabolic syndrome in Japanese based on prospective evidence: the Hisayama study. Reviewed International journal

    Doi Y, Ninomiya T, Hata J, Yonemoto K, Arima H, Kubo M, Tanizaki Y, Iwase M, Iida M, Kiyohara Y.

    Stroke   40   2009.1

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  • Seroprevalence of herpes simplex virus 1 and 2 in a population-based cohort in Japan. Reviewed International journal

    Doi Y, Ninomiya T, Hata J, Yonemoto K, Tanizaki Y, Arima H, Liu Y, Rahman M, Iida M, Kiyohara Y.

    J Epidemiol   19   2009.1

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  • Risks of cardiovascular events and effects of routine blood pressure lowering among patients with type 2 diabetes and atrial fibrillation: results of the ADVANCE study. Reviewed International journal

    Du X, Ninomiya T, de Galan B, Abadir E, Chalmers J, Pillai A, Woodward M, Cooper M, Harrap S, Hamet P, Poulter N, Lip GY, Patel A; ADVANCE Collaborative Group.

    Eur Heart J   30   2009.1

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  • Effect of lowering blood pressure on cardiovascular events and mortality in patients on dialysis: a systematic review and meta-analysis of randomised controlled trials. Reviewed International journal

    Heerspink HJ, Ninomiya T, Zoungas S, de Zeeuw D, Grobbee DE, Jardine MJ, Gallagher M, Roberts MA, Cass A, Neal B, Perkovic V.

    Lancet   373   2009.1

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  • Effects of the end point adjudication process on the results of the Perindopril Protection Against Recurrent Stroke Study (PROGRESS). Reviewed International journal

    Ninomiya T, Donnan G, Anderson N, Bladin C, Chambers B, Gordon G, Sharpe N, Chalmers J, Woodward M, Neal B; PROGRESS Collaborative Group.

    Stroke   40   2009.1

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  • Proteinuria and stroke: a meta-analysis of cohort studies. Reviewed International journal

    Ninomiya T, Perkovic V, Verdon C, Barzi F, Cass A, Gallagher M, Jardine M, Anderson C, Chalmers J, Craig JC, Huxley R.

    Am J Kidney Dis   53   2009.1

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  • Albuminuria and kidney function independently predict cardiovascular and renal outcomes in diabetes. Reviewed International journal

    Ninomiya T, Perkovic V, de Galan BE, Zoungas S, Pillai A, Jardine M, Patel A, Cass A, Neal B, Poulter N, Mogensen CE, Cooper M, Marre M, Williams B, Hamet P, Mancia G, Woodward M, Macmahon S, Chalmers J; ADVANCE Collaborative Group.

    J Am Soc Nephrol   20   2009.1

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  • Intensive glucose control and macrovascular outcomes in type 2 diabetes. Reviewed International journal

    Turnbull FM, Abraira C, Anderson RJ, Byington RP, Chalmers JP, Duckworth WC, Evans GW, Gerstein HC, Holman RR, Moritz TE, Neal BC, Ninomiya T, Patel AA, Paul SK, Travert F, Woodward M.

    Diabetologia   52   2009.1

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  • Systematic review: sodium bicarbonate treatment regimens for the prevention of contrast-induced nephropathy. Reviewed International journal

    Zoungas S, Ninomiya T, Huxley R, Cass A, Jardine M, Gallagher M, Patel A, Vasheghani-Farahani A, Sadigh G, Perkovic V.

    Ann Intern Med   151   2009.1

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  • Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: New results from the ADVANCE trial. Reviewed International journal

    Zoungas S, de Galan BE, Ninomiya T, Grobbee D, Hamet P, Heller S, MacMahon S, Marre M, Neal B, Patel A, Woodward M, Chalmers J; ADVANCE Collaborative Group, Cass A, Glasziou P, Harrap S, Lisheng L, Mancia G, Pillai A, Poulter N, Perkovic V, Travert F.

    Diabetes Care   32   2009.1

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  • Do men and women respond differently to blood pressure-lowering treatment? Results of prospectively designed overviews of randomized trials. Reviewed International journal

    Turnbull F, Woodward M, Neal B, Barzi F, Ninomiya T, Chalmers J, Perkovic V, Li N, MacMahon S; Blood Pressure Lowering Treatment Trialists' Collaboration.

    Eur Heart J   29   2008.1

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  • The improvement of renal survival with steroid pulse therapy in IgA nephropathy. Reviewed International journal

    Katafuchi R, Ninomiya T, Mizumasa T, Ikeda K, Kumagai H, Nagata M, Hirakata H.

    Nephrol Dial Transplant   23   2008.1

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  • Impact of kidney disease and blood pressure on the development of cardiovascular disease: an overview from the Japan Arteriosclerosis Longitudinal Study. Reviewed International journal

    Ninomiya T, Kiyohara Y, Tokuda Y, Doi Y, Arima H, Harada A, Ohashi Y, Ueshima H; Japan Arteriosclerosis Longitudinal Study Group.

    Circulation   118   2008.1

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  • Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. Reviewed International journal

    Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M, Marre M, Cooper M, Glasziou P, Grobbee D, Hamet P, Harrap S, Heller S, Liu L, Mancia G, Mogensen CE, Pan C, Poulter N, Rodgers A, Williams B, Bompoint S, de Galan BE, Joshi R, Travert F; ADVANCE Collaborative Group.

    N Engl J Med   358   2008.1

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  • The relationship between proteinuria and coronary risk: a systematic review and meta-analysis. Reviewed International journal

    Perkovic V, Verdon C, Ninomiya T, Barzi F, Cass A, Patel A, Jardine M, Gallagher M, Turnbull F, Chalmers J, Craig J, Huxley R.

    PLoS Med   5   2008.1

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  • Effects of different regimens to lower blood pressure on major cardiovascular events in older and younger adults: meta-analysis of randomised trials. Reviewed International journal

    Turnbull F, Neal B, Ninomiya T, Algert C, Arima H, Barzi F, Bulpitt C, Chalmers J, Fagard R, Gleason A, Heritier S, Li N, Perkovic V, Woodward M, MacMahon S; Blood Pressure Lowering Treatment Trialists' Collaboration.

    BMJ   336   2008.1

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  • Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. Reviewed International journal

    Patel A, MacMahon S, Chalmers J, Neal B, Woodward M, Billot L, Harrap S, Poulter N, Marre M, Cooper M, Glasziou P, Grobbee DE, Hamet P, Heller S, Liu LS, Mancia G, Mogensen CE, Pan CY, Rodgers A, Williams B; ADVANCE Collaborative Group.

    Lancet   370   2007.1

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  • A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction. Reviewed International journal

    Kubo M, Hata J, Ninomiya T, Matsuda K, Yonemoto K, Nakano T, Matsushita T, Yamazaki K, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Sueishi K, Iida M, Nakamura Y, Kiyohara Y.

    Nat Genet   39   2007.1

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  • Impact of metabolic syndrome on the development of cardiovascular disease in a general Japanese population: the Hisayama study. Reviewed International journal

    Ninomiya T, Kubo M, Doi Y, Yonemoto K, Tanizaki Y, Rahman M, Arima H, Tsuryuya K, Iida M, Kiyohara Y.

    Stroke   38   2007.1

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  • Prehypertension increases the risk for renal arteriosclerosis in autopsies: the Hisayama Study. Reviewed International journal

    Ninomiya T, Kubo M, Doi Y, Yonemoto K, Tanizaki Y, Tsuruya K, Sueishi K, Tsuneyoshi M, Iida M, Kiyohara Y.

    J Am Soc Nephrol   18   2007.1

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  • Metabolic syndrome and CKD in a general Japanese population: the Hisayama Study. Reviewed International journal

    Ninomiya T, Kiyohara Y, Kubo M, Yonemoto K, Tanizaki Y, Doi Y, Hirakata H, Iida M.

    Am J Kidney Dis   48   2006.1

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  • Decreasing incidence of lacunar vs other types of cerebral infarction in a Japanese population. Reviewed International journal

    Kubo M, Kiyohara Y, Ninomiya T, Tanizaki Y, Yonemoto K, Doi Y, Hata J, Shikata K, Iida M.

    Neurology   66   2006.1

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  • Chronic kidney disease and cardiovascular disease in a general Japanese population: the Hisayama Study. Reviewed International journal

    Ninomiya T, Kiyohara Y, Kubo M, Tanizaki Y, Doi Y, Okubo K, Wakugawa Y, Hata J, Oishi Y, Shikata K, Yonemoto K, Hirakata H, Iida M.

    Kidney Int   68 ( 1 )   228 - 236   2005.1

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    DOI: 10.1111/j.1523-1755.2005.00397.x

  • Hyperhomocysteinemia and the development of chronic kidney disease in a general population: the Hisayama study. Reviewed International journal

    Ninomiya T, Kiyohara Y, Kubo M, Tanizaki Y, Tanaka K, Okubo K, Nakamura H, Hata J, Oishi Y, Kato I, Hirakata H, Iida M.

    Am J Kidney Dis   44 ( 3 )   437 - 445   2004.1

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    DOI: 10.1053/j.ajkd.2004.05.024

  • Antioxidant ameliorates cisplatin-induced renal tubular cell death through inhibition of death receptor-mediated pathways. Reviewed International journal

    Tsuruya K, Tokumoto M, Ninomiya T, Hirakawa M, Masutani K, Taniguchi M, Fukuda K, Kanai H, Hirakata H, Iida M.

    Am J Physiol Renal Physiol   285 ( 2 )   F208 - F218   2003.1

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    DOI: 10.1152/ajprenal.00311.2002

  • Myeloperoxidase-antineutrophil cytoplasmic antibody-associated glomerulonephritis superimposed on biopsy-proven diabetic nephrosclerosis. Reviewed International journal

    Ninomiya T, Kanai H, Hirakawa M, Arimura Y, Masutani K, Kashiwagi M, Nakamura S, Koga Y, Fukuda K, Hirakata H.

    Am J Kidney Dis   39 ( 1 )   2002.1

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    DOI: 10.1053/ajkd.2002.29925

  • Vgamma1+ gammadelta T cells play protective roles at an early phase of murine cytomegalovirus infection through production of interferon-gamma. Reviewed International journal

    Ninomiya T, Takimoto H, Matsuzaki G, Hamano S, Yoshida H, Yoshikai Y, Kimura G, Nomoto K.

    Immunology   99 ( 2 )   187 - 194   2000.1

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    DOI: 10.1046/j.1365-2567.2000.00938.x

  • Differential brain volume between obese and underweight cognitively normal older adults with frailty in the JPSC-AD

    Ishizuka, N; Akasaka, H; Sato, M; Sato, Y; Hosokawa, K; Takahashi, J; Yonezawa, H; Terayama, Y; Ohara, T; Honda, T; Shibata, M; Hata, J; Tatewaki, Y; Taki, Y; Mikami, T; Ono, K; Mimura, M; Nakashima, K; Iga, JI; Takebayashi, M; Ninomiya, T; Maeda, T

    SCIENTIFIC REPORTS   15 ( 1 )   19702   2025.6   ISSN:2045-2322

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  • Intracellular and Extracellular Localization of Transthyretin and Its Association With Amyloid-β in Alzheimer's Disease Brains

    Mizuno, Y; Honda, H; Noguchi, H; Koyama, S; Kikutake, C; Ninomiya, T; Yamasaki, R; Isobe, N

    NEUROPATHOLOGY   e70015   2025.5   ISSN:0919-6544 eISSN:1440-1789

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    Transthyretin (TTR) can bind to Aβ and prevent the formation of Aβ fibrils in vitro; it is thus a highly interesting molecule in the field of Alzheimer's disease (AD) research. However, the distribution of TTR and its affinity to Aβ in both healthy human brains and those of AD patients remain unclear. We therefore examined TTR in human brains using postmortem brain samples. Paraffin sections and extracted protein samples were prepared from AD and control (non-AD) brains. Immunohistochemistry was performed to detect TTR expression patterns, and immunofluorescent staining was used to reveal the relationships between the intracellular and extracellular localizations of TTR and Aβ. We also performed western blotting for TTR using brain extracts. In immunohistochemical staining of the human brain, TTR signal was detected not only in extracellular tissue but also in the cytoplasm of neurons and glia. The TTR-positive area was significantly greater in AD brains than in non-AD brains. However, expression of TTR transcripts did not differ between AD and non-AD brains in our previously obtained RNA-sequencing and microarray data. Immunofluorescent staining with multiple antibodies revealed that TTR was co-localized with Aβ in the cytoplasm of neurons. In extracellular Aβ plaques, TTR presented in the same region but was not co-localized with dense Aβ fibrils. Together, our results indicate that TTR is widely expressed in the human brain rather than being limited to the choroid plexus and that TTR is more abundant in AD brains. Our results also suggest that the affinity between TTR and Aβ changes depending on the structure of Aβ. Our data will be valuable for the future development of TTR-related AD preventative methods and medications.

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  • Developing and Validating a New Atrial Fibrillation Risk Score Using Medical Examination Items in a Japanese Population ― The Suita Study ―

    Arafa Ahmed, Kato Yuka, Sakata Satoko, Ninomiya Toshiharu, Khairan Paramita, Kawachi Haruna, Nakao Yoko M., Matsumoto Chisa, Mizuno Atsushi, Kokubo Yoshihiro

    Circulation Journal   89 ( 6 )   819 - 825   2025.5   ISSN:13469843 eISSN:13474820

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    <p><b><i>Background:</i></b> The aim of this was to develop an atrial fibrillation (AF) risk score using items usually included in Japanese governmental health check-ups.</p><p><b><i>Methods and Results:</i></b> We analyzed data from 6,476 Japanese participants registered in the Suita Study. At baseline, the participants were aged ≥30 years and were free from AF. Cox regression analysis was used to identify AF risk factors, and a 0–100 score was developed to predict AF events within 10 years. Within a median follow-up of 14.6 years, 278 participants developed AF. The risk score incorporated age [<50 years (16 points for men, 0 for women), 50–59 years (26 points for men, 14 for women), 60–69 years (41 points for men, 37 for women), ≥70 years (54 points for men, 51 for women)], current smoking with a smoking index >500 (7 points), heavy alcohol consumption (8 points), body mass index ≥25 kg/m<sup>2</sup>(6 points), hypertension (7 points), urinary proteins (4 points), glutamic-pyruvic transaminase >50 IU/dL (4 points), and cardiovascular disease history (10 points). The 10-year AF event probabilities were 7.1%, 8.4%, 10.8%, and 15.9% for scores of 47–54, 55–58, 59–69, and ≥70, respectively.</p><p><b><i>Conclusions:</i></b> The new risk score to predict AF uses items similar to those used in Japanese governmental health check-ups.</p>

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  • Influence of chronic pain on regional brain volume reduction in a general older Japanese population: a longitudinal imaging analysis from the Hisayama Study.

    Nakamura Y, Shibata M, Hirabayashi N, Nakazawa T, Furuta Y, Hata J, Hosoi M, Sudo N, Yamaura K, Ninomiya T

    Brain Commun 7   7   fcaf149   2025.4

  • Impaired family functioning is associated with depressive symptoms in a community-dwelling Japanese population: The Hisayama Study

    Nagasawa F., Shibata M., Hirabayashi N., Chen S., Yoshida D., Hata J., Sudo N., Ninomiya T.

    Journal of Affective Disorders Reports   20   2025.4

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    Background: Several clinical studies have reported an association between impaired family functioning and depressive symptoms. However, epidemiological evidence is limited. The aim of this study was to investigate the association between family functioning and the presence of depressive symptoms in a community-dwelling Japanese population. Methods: A total of 2,595 participants aged ≥40 years were included. Impaired family functioning levels were assessed by using a short version of the general functioning subscale of the McMaster Family Assessment Device (GF6+). Impaired family functioning levels were categorized as healthy (GF6+ score: ≤1.80), borderline (1.81–2.00), or unhealthy (>2.00). The presence of depressive symptoms was defined as a score of ≥10 on Patient Health Questionaire-9. A logistic regression model was used to compute the odds ratios (ORs) for the presence of depressive symptom. Results: The age-adjusted prevalence of depressive symptoms was 5.4 % for men and 7.0 % for women. In both sexes, the age-adjusted prevalence of depressive symptoms increased significantly with increasing impaired family functioning levels (both P for trend <0.001). The ORs (95 % confidence intervals) for having depressive symptoms among the borderline and unhealthy groups were 3.32 (1.51–7.29) and 4.09 (1.76–9.54) for men, and 1.04 (0.56–1.95) and 3.02 (1.76–5.18) for women, respectively, compared with the healthy group after adjustment for potential confounders. Limitation: Reverse causality is possible due to the cross-sectional design. Conclusions: Impaired family functioning was associated with an increased risk of the presence of depressive symptoms. It may be important considering the family functioning in managing depressive symptoms.

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  • Comment on "Association Between Dynapenic Obesity and Risk of Cardiovascular Disease: The Hisayama Study" by Setoyama et al. -The Authors' Reply

    Setoyama, Y; Honda, T; Ninomiya, T

    JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE   16 ( 2 )   e13764   2025.4   ISSN:2190-5991 eISSN:2190-6009

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  • The prevalence of chronic pain and its impact on activities of daily living disability and depressive symptoms according to multiple definitions in a Japanese population: the Hisayama study

    Shibata, M; Hosoi, M; Anno, K; Hirabayashi, N; Morisaki, Y; Saito, T; Sudo, N; Ninomiya, T

    PAIN REPORTS   10 ( 2 )   e1250   2025.4   eISSN:2471-2531

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    Objectives:This study aimed to compare the prevalence of chronic pain using various definitions from previous studies and to determine the optimal definition for detecting chronic pain associated with physical and emotional dysfunction in a general Japanese population.Methods:A total of 2700 community-dwelling Japanese residents aged ≥40 years were assessed for chronic pain and its components of duration, frequency, and intensity. The activities of daily living (ADL) disability and depressive symptoms of participants were also evaluated using the modified Lankin Scale and Patient Health Questionnaire-9. The odds ratios and the population attributable fractions (PAFs) for ADL disability and depressive symptoms were estimated using a logistic regression model.Results:The prevalence of chronic pain varied greatly by definition, ranging from 13% for pain defined as pain duration ≥3 months, pain frequency ≥ twice a week, and pain intensity of ≥50 mm by a visual analogue scale (VAS) to 48% for a simple definition of pain duration ≥3 months. The PAFs for ADL disability and depressive symptoms were relatively high at 33% in participants with pain duration of ≥6 months and 30% in those with pain frequency of ≥twice a week, while the VAS ≥50 mm group had a low PAF of 12%.Conclusion:For screening people with chronic pain and ADL disability or depressive symptoms, the criteria of pain duration and pain frequency yielded essentially identical results, while the criterion of pain intensity risked overlooking individuals with chronic pain and these associated symptoms.

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  • Global Effect of Cardiovascular Risk Factors on Lifetime Estimates.

    Global Cardiovascular Risk Consortium, Magnussen C, Alegre-Diaz J, Al-Nasser LA, Amouyel P, Aviles-Santa L, Bakker SJL, Ballantyne CM, Bernabé-Ortiz A, Bobak M, Boffetta P, Brenner H, Brunström M, Can G, Carrillo-Larco RM, Checkley W, Dallongeville J, De Bacquer D, de Gaetano G, de Lemos JA, di Carluccio E, Dobson A, Donfrancesco C, Dörr M, d'Orsi E, Drygas W, Dullaart RPF, Engström G, Ferrario MM, Ferrières J, Figtree GA, Gaye B, Ghayour-Mobarhan M, Goldbourt U, Gonzalez C, Gossling A, Grassi G, Gupta PC, He J, Hodge AM, Hozawa A, Hveem K, Iacoviello L, Ikram MK, Inoue M, Irazola V, Jobe M, Jousilahti P, Kaleebu P, Kavousi M, Kee F, Khalili D, Klotsche J, Koenig W, Kontsevaya A, Kowlessur S, Kuri-Morales P, Kuulasmaa K, Kweon SS, Lackner KJ, Landmesser U, Leistner DM, Leiva Sisnieguez CE, Leong D, Lind L, Linneberg A, Lorenz T, Lyngbakken MN, Malekzadeh R, Malyutina S, Mathiesen EB, McElduff P, Melander O, Metspalu A, Miranda JJ, Moitry M, Mugisha J, Munzinger J, Nalini M, Nambi V, Nilsson PM, Ninomiya T, Omland T, Ong SK, Oppermann K, Pajak A, Palmieri L, Panagiotakos D, Park SK, Pednekar MS, Perianayagam A, Peters A, Poustchi H, Prabhakaran D, Prentice AM, Prescott E, Quyyumi A, Risérus U, Sakata S, Salazar M, Salomaa V, Sans S, Sattler ELP, Schöttker B, Schutte AE, Sepanlou SG, Sharma SK, Shaw J, Simons LA, Söderberg S, Tamosiunas A, Tapia-Conyer R, Thorand B, Tunstall-Pedoe H, Tuomilehto J, Twerenbold R, Vanuzzo D, Veronesi G, Wannamethee SG, Watanabe M, Weimann J, Wild PS, Yao Y, Zeng Y, Ziegler A, Ojeda FM, Blankenberg S

    The New England journal of medicine   2025.3   ISSN:0028-4793

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  • Association of impaired olfactory identification with prevalent mild cognitive impairment and regional brain atrophy: the Hisayama Study

    Minohara, T; Ohara, T; Nakazawa, T; Hirabayashi, N; Furuta, Y; Shibata, M; Hata, J; Kitazono, T; Nakao, T; Ninomiya, T

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   2025.3   ISSN:1323-1316 eISSN:1440-1819

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    Aim: To investigate the association of olfactory identification ability with both the prevalence of mild cognitive impairment (MCI) and regional brain atrophy in a community-dwelling older population. Methods: A total of 1293 participants without dementia aged 65 years or older underwent a Japanese version of the 4-Item Pocket Smell Test, an assessment of cognitive function, and brain magnetic resonance imaging scanning in 2017–2018. Regional gray matter volumes (GMVs) and white matter lesions volume (WMLV) were estimated using FreeSurfer software. The association of impaired olfactory identification with the presence of MCI and regional GMVs or WMLV was estimated by logistic regression analysis and ANCOVA, respectively. We also assessed the association between impaired olfactory identification and GMVs without regions of interest, using a voxel-based morphometry (VBM) analysis. Results: Participants with impaired olfactory identification had a significantly higher likelihood of MCI than those without (odds ratio, 1.99 [95% confidence interval, 1.36–2.91]). In the FreeSurfer analysis, participants with impaired olfactory identification had significantly lower GMVs in the entorhinal cortex, inferior temporal gyrus, amygdala, thalamus, hippocampus, and cingulate gyrus, and higher WMLV than those without. The VBM analysis also showed that impaired olfactory identification was significantly associated with lower volume of the left entorhinal cortex, left amygdala, left hippocampus, bilateral thalami, and bilateral subcallosal areas. Conclusion: Our findings suggest that cognitive function and brain changes may need to be evaluated in older individuals with impaired olfactory identification, which may reflect the extent of neurodegeneration, WMLV, and subsequent cognitive impairment.

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  • 特集 孤立・孤独 社会的孤立および孤独感が認知症リスクに及ぼす影響に関する疫学的知見

    二宮 利治

    BRAIN and NERVE   77 ( 2 )   119 - 125   2025.2   ISSN:18816096 eISSN:13448129

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  • The prevalence of chronic pain and its impact on activities of daily living disability and depressive symptoms according to multiple definitions in a Japanese population: the Hisayama Study.

    Shibata M, Hosoi M, Anno K, Hirabayashi N, Morisaki Y, Saito T, Sudo N, Ninomiya T

    Pain Rep   10   e1250   2025.2

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  • Association of sarcopenia with regional brain atrophy and white matter lesions in a general older population: the Hisayama Study.

    Tajimi T, Hirabayashi N, Furuta Y, Nakazawa T, Honda T, Hata J, Ohara T, Shibata M, Kitazono T, Nakashima Y, Ninomiya T

    Geroscience   47   1187 - 1198   2025.2

  • Green tea consumption and cerebral white matter lesions in community-dwelling older adults without dementia

    Shibata, S; Noguchi-Shinohara, M; Shima, A; Ozaki, T; Usui, Y; Taki, Y; Uchida, K; Honda, T; Hata, J; Ohara, T; Mikami, T; Maeda, T; Mimura, M; Nakashima, K; Iga, JI; Takebayashi, M; Ninomiya, T; Ono, K

    NPJ SCIENCE OF FOOD   9 ( 1 )   2   2025.1   eISSN:2396-8370

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  • Green tea consumption and cerebral white matter lesions in community-dwelling older adults without dementia.

    Shibata S, Noguchi-Shinohara M, Shima A, Ozaki T, Usui Y, Taki Y, Uchida K, Honda T, Hata J, Ohara T, Mikami T, Maeda T, Mimura M, Nakashima K, Iga J, Takebayashi M, Ninomiya T, Ono K; Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) study group

    NPJ Sci Food   9 ( 2 )   2025.1

  • Impaired family functioning is associated with depressive symptoms in a community-dwelling Japanese population: the Hisayama Study.

    Nagasawa F, Shibata M, Hirabayashi N, Chen S, Yoshida D, Hata J, Sudo N, Ninomiya T

    J Affect Disord Rep   20   100900   2025

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  • Influence of chronic pain on regional brain volume reduction in a general older Japanese population: a longitudinal imaging analysis from the Hisayama Study

    Nakamura, Y; Shibata, M; Hirabayashi, N; Nakazawa, T; Furuta, Y; Hata, J; Hosoi, M; Sudo, N; Yamaura, K; Ninomiya, T

    BRAIN COMMUNICATIONS   7 ( 2 )   fcaf149   2025   eISSN:2632-1297

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    Longitudinal analyses of the influence of chronic pain on pain-related regional brain volumes in general populations are warranted. This prospective cohort study investigated the association between the presence of chronic pain at baseline and the subsequent changes in pain-related regional brain volumes among Japanese community-dwelling older residents. Participants aged 65 years or older who underwent brain magnetic resonance imaging (MRI) scans in both 2012 and 2017 were included. According to the presence or absence of chronic pain (defined as pain lasting for longer than 3 months) in 2012, participants were categorized into a 'chronic pain' group and 'no chronic pain' group. Region-of-interest analyses for the ventrolateral prefrontal cortex, dorsolateral prefrontal cortex, orbitofrontal cortex, postcentral gyrus, insular cortex, thalamus, anterior cingulate cortex, posterior cingulate cortex, amygdala and hippocampus were performed using FreeSurfer software. Whole-brain analysis was conducted by voxel-based morphometry. Rates of change in regional brain volume at 5 years after baseline were estimated using analysis of covariance. Among the 766 participants included in the FreeSurfer analysis, 444 (58%) were female and 287 (37%) were categorized into the chronic pain group. The results of FreeSurfer analysis showed that the chronic pain group had significantly greater decreases in regional volume in the postcentral gyrus (-2.187% in the chronic pain group versus -1.681% in the no chronic pain group, P = 0.01), thalamus (-4.400% versus -3.897%, P = 0.006), anterior cingulate cortex (-2.507% versus -1.941%, P = 0.004) and amygdala (-4.739% versus -4.022%, P = 0.03) compared to the no chronic pain group after adjusting for age, sex, education attainment, marital status, hypertension, diabetes, serum total cholesterol level, body mass index, current smoking, current drinking, regular exercise, cerebrovascular lesions on MRI, activities in daily living disability and depressive symptoms. Among the 730 participants included in the voxel-based morphometry analysis, 433 (59%) were female and 272 (37%) were categorized into the chronic pain group. The voxel-based morphometry analysis showed that the chronic pain group had a significantly greater regional volume decrease in the right anterior insula than the no chronic pain group. Our findings suggest that the presence of chronic pain at baseline is associated with a significantly greater decrease in the volume of pain-related brain regions at 5 years after baseline in community-dwelling older Japanese.

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  • Transition of Metabolic Health Status and the Risk of Cardiovascular Diseases in a Japanese Population: the Hisayama Study

    Higashioka Mayu, Sakata Satoko, Oishi Emi, Honda Takanori, Shibata Mao, Hata Jun, Kitazono Takanari, Osawa Haruhiko, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   advpub ( 0 )   2025   ISSN:13403478 eISSN:18803873

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    <p> <b>Aims:</b> To investigate the association between metabolic health status, defined by the combination of metabolic syndrome (MetS) and obesity, and cardiovascular disease (CVD) in a Japanese community.</p><p><b>Methods:</b> A total of 2,842 participants without prior CVD, aged 40 years or older, were followed up from 2007 until 2017. Participants were classified into 4 metabolic health statuses based on the presence of obesity (body mass index ≥ 25 kg/m<sup>2</sup>) and MetS: metabolically healthy normal weight (MHN) (obesity [-] and MetS [-]), metabolically unhealthy normal weight (MUN) (obesity [-] and MetS [+]), metabolically healthy obesity (MHO) (obesity [+] and MetS [-]), and metabolically unhealthy obesity (MUO) (obesity [+] and MetS [+]). The risk estimates were computed by using a Cox hazard regression analysis.</p><p> <b>Results:</b> During the follow-up period, 190 participants developed CVD. The MUO group had a 1.94-times greater risk of developing CVD than the MHN group after adjusting for confounders, but no excess risk was observed in the MHO group. Moreover, in 1,595 participants who had undergone a health checkup in 2002, 5 years before baseline, the risk of developing CVD was 2.18-times greater in the group that transitioned from MHO to MUO and 1.75-times higher in the stable MUO group than in the stable MHN group, but was not higher in the stable MHO group.</p><p><b>Conclusions:</b> The present findings suggest that cardiovascular risk increases when metabolic abnormalities are present simultaneously with obesity. In individuals with obesity, it may be important to maintain metabolic health and/or lose weight to prevent CVD.</p>

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  • Novel method for classification of prion diseases by detecting PrPres signal patterns from formalin-fixed paraffin-embedded samples. International journal

    Sachiko Koyama, Kaoru Yagita, Hideomi Hamasaki, Hideko Noguchi, Masahiro Shijo, Kosuke Matsuzono, Kei-Ichiro Takase, Keita Kai, Shin-Ichi Aishima, Kyoko Itoh, Toshiharu Ninomiya, Naokazu Sasagasako, Hiroyuki Honda

    Prion   18 ( 1 )   40 - 53   2024.12   ISSN:1933-6896 eISSN:1933-690X

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    Prion disease is an infectious and fatal neurodegenerative disease. Western blotting (WB)-based identification of proteinase K (PK)-resistant prion protein (PrPres) is considered a definitive diagnosis of prion diseases. In this study, we aimed to detect PrPres using formalin-fixed paraffin-embedded (FFPE) specimens from cases of sporadic Creutzfeldt-Jakob disease (sCJD), Gerstmann-Sträussler-Scheinker disease (GSS), glycosylphosphatidylinositol-anchorless prion disease (GPIALP), and V180I CJD. FFPE samples were prepared after formic acid treatment to inactivate infectivity. After deparaffinization, PK digestion was performed, and the protein was extracted. In sCJD, a pronounced PrPres signal was observed, with antibodies specific for type 1 and type 2 PrPres exhibited a strong or weak signals depending on the case. Histological examination of serial sections revealed that the histological changes were compatible with the biochemical characteristics. In GSS and GPIALP, prion protein core-specific antibodies presented as PrPres bands at 8-9 kDa and smear bands, respectively. However, an antibody specific for the C-terminus presented as smears in GSS, with no PrPres detected in GPIALP. It was difficult to detect PrPres in V180I CJD. Collectively, our findings demonstrate the possibility of detecting PrPres in FFPE and classifying the prion disease types. This approach facilitates histopathological and biochemical evaluation in the same sample and is safe owing to the inactivation of infectivity. Therefore, it may be valuable for the diagnosis and research of prion diseases.

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  • Association between dynapenic obesity and risk of cardiovascular disease: the Hisayama study.

    Setoyama Y, Honda T, Tajimi T, Sakata S, Oishi E, Furuta Y, Shibata M, Hata J, Kitazono T, Nakashima Y, Ninomiya T

    J Cachexia Sarcopenia Muscle   15   2338 - 2348   2024.12

  • Association between dynapenic obesity and risk of cardiovascular disease: The Hisayama study

    Setoyama, Y; Honda, T; Tajimi, T; Sakata, S; Oishi, E; Furuta, Y; Shibata, M; Hata, J; Kitazono, T; Nakashima, Y; Ninomiya, T

    JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE   15 ( 6 )   2338 - 2348   2024.12   ISSN:2190-5991 eISSN:2190-6009

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    Background: Dynapenic obesity is a condition characterized by high adiposity levels combined with muscle dysfunction. Although high adiposity and muscle loss/dysfunction are thought to synergistically increase the risk of cardiovascular disease (CVD), few studies have addressed the association between dynapenic and sarcopenic obesity and CVD. We aimed to investigate the association of dynapenic obesity with incident CVD events using the data from a population-based prospective longitudinal study in Japan. Methods: A total of 2490 community-dwelling Japanese aged 40–79 years (42.5% males, mean age 57.7 ± 10.6 years) without a history of CVD were followed up for a median of 24 years. Handgrip strength was classified as low, medium, or high by age- and sex-specific tertiles. Body mass index (BMI) levels were categorized as lean (<18.5 kg/m<sup>2</sup>), normal (18.5–24.9 kg/m<sup>2</sup>), or obese (≥25.0 kg/m<sup>2</sup>). Dynapenic obesity was defined as having both low handgrip strength and obesity. The outcomes were defined as the first-ever development of CVD (defined as stroke or coronary heart disease). The hazard ratios (HRs) and their 95% confidence intervals (CIs) for the development of CVD were estimated using a Cox proportional hazards model, in which participants with high handgrip strength and normal BMI were used as a reference group. Mediation analyses used serum high-sensitivity C-reactive protein (hs-CRP) and homeostatic model assessment for insulin resistance (HOMA-IR) as mediators. Results: During the follow-up period, 482 participants developed CVD events (324 cases of stroke and 209 of coronary heart disease). The multivariable-adjusted risk of CVD increased significantly among participants with dynapenic obesity compared with the reference group (HR 1.49, 95% CI 1.03–2.17). An analysis by age groups showed a further increase in the risk of CVD among participants with dynapenic obesity aged less than 65 years (HR 1.66, 95% CI 1.04–2.65). In mediation analyses for participants aged less than 65 years, serum hs-CRP was shown to be a significant mediator explaining 13.8% of the association between dynapenic obesity and the development of CVD, while HOMA-IR explained 12.2% of this relationship. Conclusions: Dynapenic obesity was a significant risk factor for the development of CVD in a general Japanese population. This association was more pronounced among those aged <65 years. Inflammation, and possibly glucose metabolism, might partly mediate this association. Our findings suggest that preventing muscle dysfunction as well as appropriate weight control, especially in middle-age, are important for preventing the development of CVD.

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  • Common protein-altering variant in <i>GFAP</i> is associated with white matter lesions in the older Japanese population

    Furuta, Y; Akiyama, M; Hirabayashi, N; Honda, T; Shibata, M; Ohara, T; Hata, J; Terao, C; Momozawa, Y; Tatewaki, Y; Taki, Y; Nakaji, S; Maeda, T; Ono, K; Mimura, M; Nakashima, K; Iga, J; Takebayashi, M; Ninomiya, T

    NPJ GENOMIC MEDICINE   9 ( 1 )   59   2024.11   eISSN:2056-7944

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    The genetic architecture of white matter lesions (WMLs) in Asian populations has not been well-characterized. Here, we performed a genome-wide association study (GWAS) to identify loci associated with the WML volume. Brain MRI and DNA samples were collected from 9479 participants in the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD). The GWAS confirmed three known WML-associated loci (SH3PXD2A, GFAP, and TRIM47). The lead variant of GFAP was a common missense variant (p.D295N) in East Asians. Meta-GWAS using the publicly available summary statistics of UK Biobank identified one previously unreported locus 6q23.2 (SLC2A12). Integration with expression quantitative trait locus data implied the newly identified locus affects SLC2A12 expression. The effect sizes of 20 lead variants at the WML-associated loci were moderately correlated between JPSC-AD and UK Biobank. These results indicate that the alteration in GFAP protein caused by the common missense variant in East Asians influences the WML volume.

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  • Associations between the Serum Triglyceride Level and Kidney Outcome in Patients with Chronic Kidney Disease: The Fukuoka Kidney disease Registry Study

    Seki Mai, Nakano Toshiaki, Tanaka Shigeru, Kitamura Hiromasa, Hiyamuta Hiroto, Ninomiya Toshiharu, Tsuruya Kazuhiko, Kitazono Takanari

    Journal of Atherosclerosis and Thrombosis   31 ( 11 )   1556 - 1570   2024.11   ISSN:13403478 eISSN:18803873

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    <p> <b>Aims:</b> Hypertriglyceridemia is a risk factor for chronic kidney disease (CKD). However, whether or not it predicts the risk of CKD progression is unknown. This study evaluated the association between serum triglyceride (TG) levels and kidney disease progression in patients with non-dialysis-dependent CKD.</p><p><b>Methods:</b> The Fukuoka Kidney disease Registry (FKR) study was a multicenter, prospective longitudinal cohort study. In total, 4,100 patients with CKD were followed up for 5 years. The primary outcome was the incidence of CKD progression, defined as a ≥ 1.5-fold increase in serum creatinine level or the development of end-stage kidney disease. The patients were divided into quartiles according to baseline serum TG levels under non-fasting conditions: Q1 <87 mg/dL; Q2, 87–120 mg/dL; Q3, 121–170 mg/dL, and Q4 >170 mg/dL.</p><p><b>Results:</b> During the 5-year observation period, 1,410 patients met the criteria for CKD progression. The multivariable-adjusted Cox proportional hazards model showed a significant association between high serum TG level and the risk of CKD progression in the model without macroalbuminuria as a covariate (multivariable hazard ratio[HR] for Q4 versus Q1, 1.20; 95% CI, 1.03–1.41; <i>P</i>=0.022), but the significance disappeared after adjusting for macroalbuminuria (HR for Q4 versus Q1, 1.06; 95% CI, 0.90–1.24; <i>P</i>=0.507).</p><p><b>Conclusions:</b> The present findings suggest that individuals with high serum TG levels are more likely to develop CKD progression than those without; however, whether or not higher serum TG levels reflect elevated macroalbuminuria or lead to CKD progression via elevated macroalbuminuria is unclear.</p>

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  • Associations between the serum triglyceride level and kidney outcome in patients with chronic kidney disease: the Fukuoka Kidney disease Registry Study. Reviewed

    Seki M, Nakano T, Tanaka S, Kitamura H, Hiyamuta H, Ninomiya T, Tsuruya K, Kitazono T

    J Atheroscler Thromb   31   1556 - 1570   2024.11

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  • Common protein-altering variant in GFAP is associated with white matter lesions in the older Japanese population. Reviewed

    Furuta Y, Akiyama M, Hirabayashi N, Honda T, Shibata M, Ohara T, Hata J, Terao C, Momozawa Y, Tatewaki Y, Taki Y, Nakaji S, Maeda T, Ono K, Mimura M, Nakashima K, Iga JI, Takebayashi M, Ninomiya T; Japan Prospective Studies for Aging and Dementia (JPSC-AD) Study Group

    NPJ Genom Med   9   59   2024.11

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  • Novel method for classification of prion diseases by detecting PrPres signal patterns from formalin-fixed paraffin-embedded samples. Reviewed

    Koyama S, Yagita K, Hamasaki H, Noguchi H, Shijo M, Matsuzono K, Takase KI, Kai K, Aishima SI, Itoh K, Ninomiya T, Sasagasako N, Honda H

    Prion   18   40 - 53   2024.11

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  • Genetic risk stratification of primary open-angle glaucoma in Japanese individuals.

    Akiyama M, Tamiya G, Fujiwara K, Shiga Y, Yokoyama Y, Hashimoto K, Sato M, Sato K, Narita A, Hashimoto S, Ueda E, Furuta Y, Hata J, Miyake M, Ikeda HO, Suda K, Numa S, Mori Y, Morino K, Murakami Y, Shimokawa S, Nakamura S, Yawata N, Fujisawa K, Yamana S, Mori K, Ikeda Y, Miyata K, Mori K, Ogino K, Koyanagi Y, Kamatani Y; Biobank Japan Project; Ninomiya T, Sonoda KH, Nakazawa T; Japan Glaucoma Society Omics Group; Genomic Research Committee of the Japanese Ophthalmological Society

    Ophthalmology   131   1271 - 1280   2024.11

  • Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants.

    NCD Risk Factor Collaboration (NCD-RisC)( Ninomiya T, Hata J, Sakata S)

    Lancet   404   2077 - 2093   2024.11

  • Associations between the Serum Triglyceride Level and Kidney Outcome in Patients with Chronic Kidney Disease: The Fukuoka Kidney disease Registry Study(タイトル和訳中)

    Seki Mai, Nakano Toshiaki, Tanaka Shigeru, Kitamura Hiromasa, Hiyamuta Hiroto, Ninomiya Toshiharu, Tsuruya Kazuhiko, Kitazono Takanari

    Journal of Atherosclerosis and Thrombosis   31 ( 11 )   1556 - 1570   2024.11   ISSN:1340-3478

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  • Metabolomic Profiling of Open-Angle Glaucoma Etiologic Endotypes: Tohoku Multi-Omics Glaucoma Study

    Hanyuda, A; Raita, Y; Ninomiya, T; Hashimoto, K; Takada, N; Sato, K; Inoue, J; Koshiba, S; Tamiya, G; Narita, A; Akiyama, M; Omodaka, K; Tsuda, S; Yokoyama, Y; Himori, N; Yamamoto, Y; Taniguchi, T; Negishi, K; Nakazawa, T

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   65 ( 13 )   44   2024.11   ISSN:0146-0404 eISSN:1552-5783

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    PURPOSE. The purpose of this study was to investigate biologically meaningful endotypes of open-angle glaucoma (OAG) by applying unsupervised machine learning to plasma metabolites. METHODS. This retrospective longitudinal cohort study enrolled consecutive patients aged ≥20 years with OAG at Tohoku University Hospital from January 2017 to January 2020. OAG was confirmed based on comprehensive ophthalmic examinations. Among the 523 patients with OAG with available clinical metabolomic data, 173 patients were longitudinally followed up for ≥2 years, with available data from ≥5 reliable visual field (VF) tests without glaucoma surgery. We collected fasting blood samples and clinical data at enrollment and nuclear magnetic resonance spectroscopy to profile 45 plasma metabolites in a targeted approach. After computing a distance matrix of preprocessed metabolites with Pearson distance, gap statistics determined the optimal number of OAG endotypes. Its risk factors, clinical presentations, metabolomic profiles, and progression rate of sectorbased VF loss were compared across endotypes. RESULTS. Five distinct OAG endotypes were identified. The highest-risk endotype (endotype B) showed a significant faster progression of central VF loss (P = 0.007). Compared with patients with other endotypes, those with endotype B were more likely to have a high prevalence of dyslipidemia, cold extremities, oxidative stress, and low OAG genetic risk scores. Pathway analysis of metabolomic profiles implicated altered fatty acid and ketone body metabolism in this endotype, with 34 differentially enriched pathways (false discovery rate [FDR] < 0.05). CONCLUSIONS. Integrated metabolomic profiles identified five distinct etiologic endotypes of OAG, suggesting pathological mechanisms related with a high-risk group of central vision loss progression in the Japanese population.

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  • Genetic Risk Stratification of Primary Open-Angle Glaucoma in Japanese Individuals

    Akiyama M., Tamiya G., Fujiwara K., Shiga Y., Yokoyama Y., Hashimoto K., Sato M., Sato K., Narita A., Hashimoto S., Ueda E., Furuta Y., Hata J., Miyake M., Ikeda H.O., Suda K., Numa S., Mori Y., Morino K., Murakami Y., Shimokawa S., Nakamura S., Yawata N., Fujisawa K., Yamana S., Mori K., Ikeda Y., Miyata K., Mori K., Ogino K., Koyanagi Y., Kamatani Y., Matsuda K., Yamanashi Y., Furukawa Y., Morisaki T., Okada Y., Murakami Y., Muto K., Nagai A., Nakamura Y., Obara W., Yamaji K., Takahashi K., Asai S., Takahashi Y., Higashiue S., Kobayashi S., Yamaguchi H., Nagata Y., Wakita S., Nito C., Iwasaki Y.K., Murayama S., Yoshimori K., Miki Y., Obata D., Higashiyama M., Masumoto A., Koga Y., Koretsune Y., Ninomiya T., Sonoda K.H., Nakazawa T., Aihara M., Sakata R., Kashiwagi K., Mabuchi F., Kawase K., Iwata T., Tsujikawa M., Nishiguchi K.M.

    Ophthalmology   131 ( 11 )   1271 - 1280   2024.11   ISSN:01616420

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    Purpose: To assess the impact of genetic risk estimation for primary open-angle glaucoma (POAG) in Japanese individuals. Design: Cross-sectional analysis. Participants: Genetic risk scores (GRSs) were constructed based on a genome-wide association study (GWAS) of POAG in Japanese people. A total of 3625 Japanese individuals, including 1191 patients and 2434 controls (Japanese Tohoku), were used for the model selection. We also evaluated the discriminative accuracy of constructed GRSs in a dataset comprising 1034 patients and 1147 controls (the Japan Glaucoma Society Omics Group [JGS-OG] and the Genomic Research Committee of the Japanese Ophthalmological Society [GRC-JOS]) and 1900 participants from a population-based study (Hisayama Study). Methods: We evaluated 2 types of GRSs: polygenic risk scores using the pruning and thresholding procedure and a GRS using variants associated with POAG in the GWAS of the International Glaucoma Genetics Consortium (IGGC). We selected the model with the highest areas under the receiver operating characteristic curve (AUC). In the population-based study, we evaluated the correlations between GRS and ocular measurements. Main Outcome Measure: Proportion of patients with POAG after stratification according to the GRS. Results: We found that a GRS using 98 variants, which showed genome-wide significance in the IGGC, showed the best discriminative accuracy (AUC, 0.65). In the Japanese Tohoku, the proportion of patients with POAG in the top 10% individuals was significantly higher than that in the lowest 10% (odds ratio [OR], 6.15; 95% confidence interval [CI], 4.35–8.71). In the JGS-OG and GRC-JOS, we confirmed similar impact of POAG GRS (AUC, 0.64; OR [top vs. bottom decile], 5.81; 95% CI, 3.79–9.01). In the population-based study, POAG prevalence was significantly higher in the top 20% individuals of the GRS compared with the bottom 20% (9.2% vs. 5.0%). However, the discriminative accuracy was low (AUC, 0.56). The POAG GRS was correlated positively with intraocular pressure (r = 0.08: P = 4.0 × 10<sup>–4</sup>) and vertical cup-to-disc ratio (r = 0.11; P = 4.0 × 10<sup>–6</sup>). Conclusions: The GRS showed moderate discriminative accuracy for POAG in the Japanese population. However, risk stratification in the general population showed relatively weak discriminative performance. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

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  • Behavioral and psychological symptoms and brain volumes in community-dwelling older persons from the Nakayama Study

    Tachibana, A; Iga, J; Ozaki, T; Yoshino, Y; Yamazaki, K; Ochi, S; Kawabe, K; Horiuchi, F; Yoshida, T; Shimizu, H; Mori, T; Tatewaki, Y; Taki, Y; Ninomiya, T; Ueno, S

    SCIENTIFIC REPORTS   14 ( 1 )   26097   2024.10   ISSN:2045-2322

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    The frequency of behavioral and psychological symptoms of dementia (BPSD) is high, and it is a challenge to elucidate its neural substrates underlying their development. In recent years, many findings have been reported on the relationship between BPSD and brain volume in dementia patients. However, the results are not fully conclusive. Furthermore, there have been few population-based studies. Therefore, the relationship between BPSD and brain volume was investigated as an exploratory study. Of the 927 older persons who participated in the fifth Nakayama study, 90 were included in this analysis, consisting of 52 patients with mild cognitive impairment and 38 patients with dementia, with head MRI and the Neuropsychiatric Inventory (NPI) data. Multiple regression analysis was used to examine the association between the total score of each BPSD score on the NPI and brain volume estimated by FreeSurfer. On multivariate adjustment, even after false discovery rate correction, insular cortical volumes decreased significantly as total scores for apathy/indifference increased (p value = 0.002, q-value = 0.01). Similarly, total brain volume decreased significantly as total scores for appetite and eating disturbance increased (p value = 0.03), and parietal, temporal, and hippocampal cortical volumes also decreased significantly as total scores for appetite and eating disturbance increased (all p and q values < 0.05). This study’s results suggest that apathy is negatively correlated with insular cortical volume, and that appetite and eating disturbance are also correlated with brain regions, including parietal, temporal, and hippocampal volume in a community-dwelling older population.

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  • Behavioral and psychological symptoms and brain volumes in community-dwelling older persons from the Nakayama Study. Reviewed

    Tachibana A, Iga JI, Ozaki T, Yoshino Y, Yamazaki K, Ochi S, Kawabe K, Horiuchi F, Yoshida T, Shimizu H, Mori T, Tatewaki Y, Taki Y, Ninomiya T, Ueno SI

    Sci Rep   14   26097   2024.10

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  • Skin carotenoid scores and metabolic syndrome in a general Japanese population: the Hisayama Study. Reviewed

    Kimura Y, Hata J, Shibata M, Honda T, Sakata S, Furuta Y, Oishi E, Kitazono T, Ninomiya T

    Int J Obes (Lond)   48   1465 - 1471   2024.10

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  • Association between hypothalamic Alzheimer's disease pathology and body mass index: the Hisayama Study. Reviewed

    Yagita K, Honda H, Ohara T, Koyama S, Noguchi H, Oda Y, Yamasaki R, Isobe N, Ninomiya T

    Neuropathology   44   388 - 400   2024.10

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  • Skin carotenoid scores and metabolic syndrome in a general Japanese population: the Hisayama study. Reviewed International journal

    Yasumi Kimura, Jun Hata, Mao Shibata, Takanori Honda, Satoko Sakata, Yoshihiko Furuta, Emi Oishi, Takanari Kitazono, Toshiharu Ninomiya

    International journal of obesity (2005)   48 ( 10 )   1465 - 1471   2024.10   ISSN:0307-0565 eISSN:1476-5497

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    BACKGROUND: Higher vegetable intake is being promoted as an initiative to prevent lifestyle-related diseases. Carotenoids are yellow or red pigment components and are widely present in vegetables. Since ingested carotenoids accumulate in the skin, skin carotenoid levels are a quantitative indicator of vegetable intake. Recently, noninvasive optical sensors for assessing skin carotenoid levels were developed. We here examined the association between skin carotenoid scores measured using optical sensors and the presence of metabolic syndrome. METHODS: A total of 1618 individuals (604 men and 1014 women) aged ≥ 40 years (mean age 63.1 years) participated in the study. Skin carotenoid scores were determined using a noninvasive optical sensor based on multiple spatially resolved reflectance spectroscopy. Metabolic syndrome was defined based on the Joint Scientific Statement criteria developed by six international scientific societies. Multivariable-adjusted logistic regression models were used. RESULTS: The prevalence of metabolic syndrome was 31.3% (n = 506). A remarkably strong association was found between higher skin carotenoid scores and lower prevalence of metabolic syndrome after adjusting for confounders. The multivariable-adjusted odds ratio for the presence of metabolic syndrome in individuals with the highest quartile of skin carotenoid scores was 0.39 (95% confidence interval, 0.28-0.55) compared to those with the lowest quartile. CONCLUSIONS: Our findings suggest that higher skin carotenoid scores measured by non-invasive optimal sensors are significantly associated with a lower likelihood of having metabolic syndrome in the general Japanese population.

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  • Association between hypothalamic Alzheimer's disease pathology and body mass index: The Hisayama study. International journal

    Kaoru Yagita, Hiroyuki Honda, Tomoyuki Ohara, Sachiko Koyama, Hideko Noguchi, Yoshinao Oda, Ryo Yamasaki, Noriko Isobe, Toshiharu Ninomiya

    Neuropathology : official journal of the Japanese Society of Neuropathology   44 ( 5 )   388 - 400   2024.10   ISSN:0919-6544 eISSN:1440-1789

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    The hypothalamus is the region of the brain that integrates the neuroendocrine system and whole-body metabolism. Patients with Alzheimer's disease (AD) have been reported to exhibit pathological changes in the hypothalamus, such as neurofibrillary tangles (NFTs) and amyloid plaques (APs). However, few studies have investigated whether hypothalamic AD pathology is associated with clinical factors. We investigated the association between AD-related pathological changes in the hypothalamus and clinical pictures using autopsied brain samples obtained from deceased residents of a Japanese community. A total of 85 autopsied brain samples were semi-quantitatively analyzed for AD pathology, including NFTs and APs. Our histopathological studies showed that several hypothalamic nuclei, such as the tuberomammillary nucleus (TBM) and lateral hypothalamic area (LHA), are vulnerable to AD pathologies. NFTs are observed in various neuropathological states, including normal cognitive cases, whereas APs are predominantly observed in AD. Regarding the association between hypothalamic AD pathologies and clinical factors, the degree of APs in the TBM and LHA was associated with a lower body mass index while alive, after adjusting for sex and age at death. However, we found no significant association between hypothalamic AD pathology and the prevalence of hypertension, diabetes, or dyslipidemia. Our study showed that a lower BMI, which is a poor prognostic factor of AD, might be associated with hypothalamic AP pathology and highlighted new insights regarding the disruption of the brain-whole body axis in AD.

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  • 視床下部にみられたアルツハイマー病の病理とBMIの関連性 久山町研究(Association between hypothalamic Alzheimer's disease pathology and body mass index: The Hisayama study)

    Yagita Kaoru, Honda Hiroyuki, Ohara Tomoyuki, Koyama Sachiko, Noguchi Hideko, Oda Yoshinao, Yamasaki Ryo, Isobe Noriko, Ninomiya Toshiharu

    NEUROPATHOLOGY   44 ( 5 )   388 - 400   2024.10   ISSN:0919-6544

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    アルツハイマー病(AD)に関連して視床下部にみられる病理学的変化と臨床像を調査した。福岡市に隣接する久山町で2018年1月1日~2020年3月3日に死亡した住民249名のうち129名(51.8%)で剖検が行われ、そのうち解析に適した85名(男性56%、平均85.0±9.1歳)を本研究に組み入れた。認知機能が正常だったと診断されていた例は35名、AD診断例は31名存在した。脳を病理組織学的に解析したところ、結節乳頭体核(TBM)や視床下部外側野(LHA)といった視床下核のいくつかが、AD病理に冒されやすいことが明らかになった。神経原線維の変化は、認知機能正常例も含め、神経病理学的状態が様々であった剖検例にわたって観察された。それに対し、アミロイド斑はAD例で優位に観察された。視床下部のAD病理を半定量的に評価し臨床因子との関連性を検討した結果、TMBとLHAにおけるアミロイド斑の程度は生前の低BMIと関連していることが、性別・死亡年齢での調整後に示された。視床下部AD病理と、高血圧症、糖尿病、または脂質異常症の有病率との間には有意な関連性は示されなかった。以上のように、ADの予後不良因子である低BMIは、視床下部AD病理に関連していると考えられた。

  • Glucose metabolism and smaller hippocampal volume in elderly people with normal cognitive function

    Shima, A; Noguchi-Shinohara, M; Shibata, S; Usui, Y; Tatewaki, Y; Thyreau, B; Hata, J; Ohara, T; Honda, T; Taki, Y; Nakaji, S; Maeda, T; Mimura, M; Nakashima, K; Iga, J; Takebayashi, M; Nishijo, H; Ninomiya, T; Ono, K

    NPJ AGING   10 ( 1 )   39   2024.9   eISSN:2731-6068

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    We investigated associations of glycemic measures, and insulin resistance and secretion measures with hippocampal and subfield volumes. In this cross-sectional study, 7400 community-dwelling participants underwent brain MRI and health checkups between 2016 and 2018. Hemoglobin A<inf>1c</inf> (HbA<inf>1c</inf>), glycated albumin (GA), homeostasis model assessment for insulin resistance (HOMA-IR), and HOMA of percent β-cell function (HOMA-β) were evaluated. The associations of each measure with a smaller volume of the hippocampus and twelve hippocampal subfields were investigated. As a result, higher HbA<inf>1c</inf> or GA and lower HOMA-β levels were significantly associated with smaller volumes in multiple hippocampal subfields. Furthermore, even when we analyzed non-diabetic individuals, substantial associations remained between higher GA or lower HOMA-β levels and smaller volumes of the whole hippocampus or the fimbria. Our findings indicate that postprandial glucose fluctuations, postprandial hyperglycemia, and low insulin secretion have a specific effect on the development of smaller hippocampal volume, suggesting that primary prevention of diabetes and/or sufficient glucose control are important for the prevention of dementia.

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  • Vascular calcification Is accelerated by hyponatremia and Low osmolality.

    Matsueda S, Yamada S, Torisu K, Kitamura H, Ninomiya T, Nakano T, Kitazono T

    Arterioscler Thromb Vasc Biol.   44 ( 9 )   1925 - 1943   2024.9

  • Glucose metabolism and smaller hippocampal volume in elderly people with normal cognitive function.

    Shima A, Noguchi-Shinohara M, Shibata S, Usui Y, Tatewaki Y, Thyreau B, Hata J, Ohara T, Honda T, Taki Y, Nakaji S, Maeda T, Mimura M, Nakashima K, Iga JI, Takebayashi M, Nishijo H, Ninomiya T, Ono K; Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) study group

    NPJ Aging   10   39   2024.9

  • Association between corneal hysteresis and glaucoma in a Japanese population: the Hisayama Study. International journal

    Kohta Fujiwara, Emi Ueda, Jun Hata, Satoko Nakano, Sawako Hashimoto, Shun Nakamura, Yusuke Murakami, Toshiaki Kubota, Takeshi Yoshitomi, Toshiharu Ninomiya, Koh-Hei Sonoda

    The British journal of ophthalmology   108 ( 9 )   1204 - 1209   2024.9   ISSN:0007-1161 eISSN:1468-2079

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    AIMS: To investigate the association between corneal hysteresis and the presence of glaucoma and its subtypes in a general Japanese population. METHODS: We analysed the data of 2338 Japanese community-dwellers aged ≥40 years (1059 men, 1279 women) who underwent an eye examination in 2018 as part of the population-based, cross-sectional Hisayama Study. Participants were divided into quartile levels of corneal hysteresis, which had been measured with an ocular response analyzer. Glaucoma was defined based on the International Society of Geographical and Epidemiological Ophthalmology criteria. We conducted a logistic regression analysis to determine the ORs and their 95% CIs for the presence of outcomes according to the corneal hysteresis quartiles. RESULTS: Glaucoma was diagnosed in 154 participants: primary open-angle glaucoma (POAG), n=115; primary angle-closure glaucoma, n=17; exfoliation glaucoma, n=21 and secondary glaucoma without exfoliation glaucoma, n=1. After adjustment for confounders, the OR for prevalent glaucoma was significantly increased in the participants in the first corneal-hysteresis quartile compared with those in the fourth quartile (OR: 1.80; 95% CI: 1.03 to 3.17). Regarding glaucoma subtypes, the first-quartile participants had significantly greater likelihoods of the presence of POAG (OR: 1.63; 95% CI: 1.02 to 2.61) and exfoliation glaucoma (OR: 6.49; 95% CI: 1.44 to 29.30) compared with those in the third and fourth quartiles after adjustment for potential confounders. CONCLUSIONS: These results demonstrated a significant inverse association between corneal hysteresis and the likelihood of glaucoma, suggesting that the measurement of corneal hysteresis would provide useful information for elucidating the aetiology of glaucoma.

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  • Vascular Calcification Is Accelerated by Hyponatremia and Low Osmolality

    Matsueda, S; Yamada, S; Torisu, K; Kitamura, H; Ninomiya, T; Nakano, T; Kitazono, T

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   44 ( 9 )   1925 - 1943   2024.9   ISSN:1079-5642 eISSN:1524-4636

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    BACKGROUND: Hyponatremia, frequently observed in patients with chronic kidney disease, is associated with increased cardiovascular morbidity and mortality. Hyponatremia or low osmolality induces oxidative stress and cell death, both of which accelerate vascular calcification (VC), a critical phenotype in patients with chronic kidney disease. Whether hyponatremia or low osmolality plays a role in the pathogenesis of VC is unknown. METHODS: Human vascular smooth muscle cells (VSMCs) and mouse aortic rings were cultured in various osmotic conditions and calcifying medium supplemented with high calcium and phosphate. The effects of low osmolality on phenotypic change and oxidative stress in the cultured VSMCs were examined. Microarray analysis was conducted to determine the main signaling pathway of osmolality-related VC. The transcellular sodium and calcium ions flux across the VSMCs were visualized by live imaging. Furthermore, the effect of osmolality on calciprotein particles (CPPs) was investigated. Associations between arterial intimal calcification and hyponatremia or low osmolality were examined by a cross-sectional study using human autopsy specimens obtained in the Hisayama Study. RESULTS: Low osmolality exacerbated calcification of the ECM (extracellular matrix) of cultured VSMCs and mouse aortic rings. Oxidative stress and osteogenic differentiation of VSMCs were identified as the underlying mechanisms responsible for low osmolality-induced VC. Microarray analysis showed that low osmolality activated the Rac1 (Ras-related C3 botulinum toxin substrate 1)-Akt (protein kinase B) pathway and reduced NCX1 (Na-Ca exchanger 1) expression. Live imaging showed synchronic calcium ion efflux and sodium ion influx via NCX1 when extracellular sodium ion concentrations were increased. An NCX1 inhibitor promoted calcifying media-induced VC by reducing calcium ion efflux. Furthermore, low osmolality accelerated the generation and maturation steps of CPPs. The cross-sectional study of human autopsy specimens showed that hyponatremia and low osmolality were associated with a greater area of arterial intimal calcification. CONCLUSIONS: Hyponatremia and low osmolality promote VC through multiple cellular processes, including the Rac1-Akt pathway activation.

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  • General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7•5 million participants

    Zhou, B; Bennett, JE; Wickham, AP; Singleton, RK; Mishra, A; Carrillo-Larco, RM; Ikeda, N; Jain, L; Barradas-Pires, A; Heap, RA; Lhoste, VPF; Sheffer, KE; Phelps, NH; Rayner, AW; Gregg, EW; Stevens, GA; Iurilli, MLC; Danaei, G; Di Cesare, M; Aguilar-Salinas, CA; Ahmad, NA; Bovet, P; Chen, ZM; Damasceno, A; Filippi, SL; Janszky, I; Kengne, AP; Khang, YH; Khunti, K; Laxmaiah, A; Lim, LL; Lissner, L; Margozzini, P; Mbanya, JC; McGarvey, S; Shaw, JE; Söderberg, S; Soto-Mota, LA; Wang, JY; Zaccardi, F; Ezzati, M; Abarca-Gómez, L; Abbasi-Kangevari, M; Abdrakhmanova, S; Ghaffar, SA; Rahim, HFA; Abdurrahmonova, Z; Abu-Rmeileh, NM; Acosta-Cazares, B; Adam, I; Adamczyk, M; Aekplakorn, W; Agdeppa, IA; Aghazadeh-Attari, J; Agyemang, C; Ahmad, MH; Ahmad, NA; Ahmadi, A; Ahmadi, N; Ahmadi, N; Ahmed, SH; Ahrens, W; Aitmurzaeva, G; Ajlouni, K; Al-Hazzaa, HM; Al-Hinai, H; Al-Lawati, JA; Al-Raddadi, R; Al Asfoor, D; Al Hourani, HM; Alarouj, M; AlBuhairan, F; AlDhukair, S; Ali, MM; Alieva, AV; Alkandari, A; Alkhatib, BM; Aly, E; Amarapurkar, DN; Etxezarreta, PA; Amougou, N; Andersen, LB; Anderssen, SA; Androutsos, O; Anjana, RM; Ansari-Moghaddam, A; Anufrieva, E; Aounallah-Skhir, H; Aris, T; Arku, RE; Arlappa, N; Aryal, KK; Assah, FK; Assembekov, B; Assunçao, MCF; Auvinen, J; Avdicová, M; Azad, K; Azevedo, A; Azimi-Nezhad, M; Azizi, F; Bacopoulou, F; Bahijri, S; Bajramovic, I; Balakrishna, N; Bamoshmoosh, M; Banach, M; Bandosz, P; Banegas, JR; Baran, R; Barbagallo, CM; Barbosa, V; Barceló, A; Baretic, M; Barnoya, J; Barrera, L; Barros, AJ; Barros, MVG; Basit, A; Bastos, JL; Batieha, AM; Batista, AP; Batista, RL; Battakova, Z; Baur, LA; Bayauli, PM; Bel-Serrat, S; Belavendra, A; Ben Romdhane, H; Benedek, T; Benedics, J; Benet, M; Rolandi, GEB; Benzeval, M; Bere, E; Berger, N; Bergh, IH; Berkinbayev, S; Bernabe-Ortiz, A; Bettiol, H; Beybey, AF; Bezerra, J; Bhagyalaxmi, A; Bhargava, SK; Lele, ECB; Bikbov, MM; Bista, B; Bjelica, DJ; Bjerregaard, P; Bjertness, E; Bjertness, MB; Björkelund, C; 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    LANCET   404 ( 10455 )   851 - 863   2024.8   ISSN:0140-6736 eISSN:1474-547X

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    Background: Adiposity can be measured using BMI (which is based on weight and height) as well as indices of abdominal adiposity. We examined the association between BMI and waist-to-height ratio (WHtR) within and across populations of different world regions and quantified how well these two metrics discriminate between people with and without hypertension. Methods: We used data from studies carried out from 1990 to 2023 on BMI, WHtR and hypertension in people aged 20–64 years in representative samples of the general population in eight world regions. We graphically compared the regional distributions of BMI and WHtR, and calculated Pearson's correlation coefficients between BMI and WHtR within each region. We used mixed-effects linear regression to estimate the extent to which WHtR varies across regions at the same BMI. We graphically examined the prevalence of hypertension and the distribution of people who have hypertension both in relation to BMI and WHtR, and we assessed how closely BMI and WHtR discriminate between participants with and without hypertension using C-statistic and net reclassification improvement (NRI). Findings: The correlation between BMI and WHtR ranged from 0·76 to 0·89 within different regions. After adjusting for age and BMI, mean WHtR was highest in south Asia for both sexes, followed by Latin America and the Caribbean and the region of central Asia, Middle East and north Africa. Mean WHtR was lowest in central and eastern Europe for both sexes, in the high-income western region for women, and in Oceania for men. Conversely, to achieve an equivalent WHtR, the BMI of the population of south Asia would need to be, on average, 2·79 kg/m<sup>2</sup> (95% CI 2·31–3·28) lower for women and 1·28 kg/m<sup>2</sup> (1·02–1·54) lower for men than in the high-income western region. In every region, hypertension prevalence increased with both BMI and WHtR. Models with either of these two adiposity metrics had virtually identical C-statistics and NRIs for every region and sex, with C-statistics ranging from 0·72 to 0·81 and NRIs ranging from 0·34 to 0·57 in different region and sex combinations. When both BMI and WHtR were used, performance improved only slightly compared with using either adiposity measure alone. Interpretation: BMI can distinguish young and middle-aged adults with higher versus lower amounts of abdominal adiposity with moderate-to-high accuracy, and both BMI and WHtR distinguish people with or without hypertension. However, at the same BMI level, people in south Asia, Latin America and the Caribbean, and the region of central Asia, Middle East and north Africa, have higher WHtR than in the other regions. Funding: UK Medical Research Council and UK Research and Innovation (Innovate UK).

    DOI: 10.1016/S0140-6736(24)01405-3

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  • Association between Vascular Calcification and Intraplaque Hemorrhage in Coronary Atherosclerosis from Autopsy: The Hisayama Study

    Nakano Toshiaki, Kitamura Hiromasa, Hata Jun, Maki Kenji, Oda Yoshinao, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   31 ( 8 )   1225 - 1237   2024.8   ISSN:13403478 eISSN:18803873

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japan Atherosclerosis Society  

    <p> <b>Aims:</b> Vascular calcification is observed in advanced atherosclerotic lesions. Vascular calcification is considered to increase the risk of intraplaque hemorrhage and subsequent plaque destabilization; however, there is limited pathohistoological evidence of the association between vascular calcification and intraplaque hemorrhage. The aim of this study was to investigate the association between vascular calcification and intraplaque hemorrhage in the coronary arteries.</p><p> <b>Methods:</b> We examined 374 coronary arteries obtained from the autopsy samples of 126 deceased individuals. The vascular calcification levels of each artery were categorized into no calcification and quintiles of calcification area size among the arteries with calcification. Macrophage infiltration and neovascularization were also evaluated. The association of the calcification area, macrophage area, or number of vessels with the presence of intraplaque hemorrhage in the coronary arteries was estimated using a logistic regression analysis.</p><p><b>Results:</b> Calcification lesions were observed in 149 coronary arteries. Arteries in the fourth quintile of calcification area size had a significantly greater likelihood of intraplaque hemorrhage than the arteries without calcification, after adjusting for confounders: odds ratio 13.13 (95% confidence interval: 2.97–58.16). After evaluating the influence of macrophage infiltration, the highest odds ratio of intraplaque hemorrhage was associated with the combination of large macrophage area and moderately sized calicification areas. The odds ratio of intraplaque hemorrhage additively increased with the combination of calcification and the number of vessels.</p><p><b>Conclusions:</b> The present findings suggest that vascular calcification is significantly associated with intraplaque hemorrhage. The association between vascular calcification and intraplaque hemorrhage may decrease above a certain size of the calcification area.</p>

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  • Association between serum NT-proBNP and gray matter atrophy patterns in an older Japanese population: the Hisayama Study.

    Hirabayashi N, Hata J, Furuta Y, Nakazawa T, Ohara T, Shibata M, Yamashita F, Kitazono T, Sudo N, Ninomiya T

    J Gerontol A Biol Sci Med Sci   79   glae075   2024.8

  • General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants.

    NCD Risk Factor Collaboration (NCD-RisC)( Ninomiya T, Hata J)

    Lancet   404   851 - 863   2024.8

  • Association between corneal hysteresis and glaucoma in a Japanese population: the Hisayama Study

    Fujiwara K, Ueda E, Hata J, Nakano S, Hashimoto S, Nakamura S, Murakami Y, Kubota T, Yoshitomi T, Ninomiya T, Sonoda KH

    Br J Ophthalmol   108   1204 - 1209   2024.8

  • Association between vascular calcification and Intraplaque hemorrhage in coronary atherosclerosis from autopsy: the Hisayama Study.

    Nakano T, Kitamura H, Hata J, Maki K, Oda Y, Kitazono T, Ninomiya T

    J Atheroscler Thromb   31   1225 - 1237   2024.8

  • 剖検にて確認された冠動脈アテローム硬化症における血管石灰化とプラーク内出血の関連性 久山町研究(Association between Vascular Calcification and Intraplaque Hemorrhage in Coronary Atherosclerosis from Autopsy: The Hisayama Study)

    Nakano Toshiaki, Kitamura Hiromasa, Hata Jun, Maki Kenji, Oda Yoshinao, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   31 ( 8 )   1225 - 1237   2024.8   ISSN:1340-3478

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    1988年1月~2005年11月に死亡した久山町住民のうち126名(男性49名)の剖検で得られた374の冠動脈を用いて、血管石灰化とプラーク内出血の関連性を評価した。149の冠動脈に石灰化病変が認められ、いずれも内膜にみられた。石灰化面積が第4五分位であった動脈では石灰化がなかった動脈と比較してプラーク内出血を有する確率が有意に高かった(p<0.001)。交絡因子について補正後のオッズ比(OR)は13.13(95%CI 2.97~58.16)であった。マクロファージ浸潤の影響を評価した結果、マクロファージ浸潤面積の増加に伴ってプラーク内出血の頻度が有意に増加した。マクロファージ浸潤面積が最も大きく、石灰化面積が中等度(第4五分位)の場合にプラーク内出血のORが最も大きかった。血管新生の影響を評価した結果、血管数の増加に伴ってプラーク内出血の頻度が有意に増加した。プラーク内出血のORは石灰化の存在と血管数により相加的に増加した。以上の結果から、血管石灰化はプラーク内出血と有意に関連し、その関連性は石灰化が一定の面積を超えると低下することが示唆された。

  • 日本人地域高齢住民におけるpreserved ratio impaired spirometryと認知症発症との関連 久山町研究(Risks of Dementia in a General Japanese Older Population With Preserved Ratio Impaired Spirometry: The Hisayama Study)

    Kawatoko Kenji, Washio Yasuyoshi, Ohara Tomoyuki, Fukuyama Satoru, Honda Takanori, Hata Jun, Nakazawa Taro, Kan-o Keiko, Inoue Hiromasa, Matsumoto Koichiro, Nakao Tomohiro, Kitazono Takanari, Okamoto Isamu, Ninomiya Toshiharu

    Journal of Epidemiology   34 ( 7-8 )   331 - 339   2024.8   ISSN:0917-5040

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    <Highlight>●preserved ratio impaired spirometry(PRISm)と認知症との関連は明らかにされていない。●本研究では、認知症のない65歳以上の日本人地域高齢住民1,202人を対象に、中央値5.0年間の追跡調査を行った。●PRISm群は、呼吸機能正常群と比べ認知症の発症リスクが約2倍であった。●PRISmは、認知症の発症リスクが高い集団であり、呼吸機能障害の重要なサブタイプといえる。(著者抄録)

  • Association of sarcopenia with regional brain atrophy and white matter lesions in a general older population: the Hisayama Study

    Tajimi, T; Hirabayashi, N; Furuta, Y; Nakazawa, T; Honda, T; Hata, J; Ohara, T; Shibata, M; Kitazono, T; Nakashima, Y; Ninomiya, T

    GEROSCIENCE   47 ( 1 )   1187 - 1198   2024.7   ISSN:2509-2715 eISSN:2509-2723

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    Sarcopenia has been reported to be associated with cognitive decline and the risk of dementia. However, few studies have addressed the association between sarcopenia and brain morphological changes in the general population. A total of 1373 community-dwelling participants aged ≥ 65 years underwent brain MRI. Sarcopenia was defined based on the Asian Working Group for Sarcopenia's criteria. The pattern of regional gray matter volume loss associated with sarcopenia were assessed using a voxel-based morphometry (VBM) analysis. Regional brain volumes, intracranial volumes (ICV), and white matter lesions volumes (WMLV) were also measured using FreeSurfer. An analysis of covariance was used to examine the associations of sarcopenia with regional brain volumes in proportion to ICV. Of the participants, 112 had sarcopenia. The participants with sarcopenia had significantly lower total brain volume/ICV and total gray matter volume/ICV and higher WMLV/ICV than those without sarcopenia after adjusting for confounders. In VBM, sarcopenia was associated with lower gray matter volume in the frontal lobe, insula, cingulate gyrus, hippocampus, amygdala, and basal ganglia. Using FreeSurfer, we confirmed that the participants with sarcopenia had significantly lower frontal, insular, cingulate, and hippocampal volumes than those without sarcopenia. The current study showed that participants with sarcopenia had significantly lower volume in the frontal lobe, insula, cingulate, and hippocampus and higher WMLV than participants without sarcopenia. As these brain regions are likely to play an important role in cognitive function, these changes may suggest a shared underlying mechanism for the progression of sarcopenia and cognitive decline.

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  • Risks of Dementia in a General Japanese Older Population With Preserved Ratio Impaired Spirometry: The Hisayama Study

    Kawatoko Kenji, Washio Yasuyoshi, Ohara Tomoyuki, Fukuyama Satoru, Honda Takanori, Hata Jun, Nakazawa Taro, Kan-o Keiko, Inoue Hiromasa, Matsumoto Koichiro, Nakao Tomohiro, Kitazono Takanari, Okamoto Isamu, Ninomiya Toshiharu

    Journal of Epidemiology   34 ( 7 )   331 - 339   2024.7   ISSN:09175040 eISSN:13499092

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    <p><b>Background:</b> Studies on the association between preserved ratio impaired spirometry (PRISm) and dementia are limited. Indeed, PRISm has often been overlooked or ignored as an index of lung function impairment. Therefore, we investigated the association of PRISm with the risk for the development of dementia in an older Japanese population.</p><p><b>Methods:</b> A total of 1,202 community-dwelling, older Japanese participants aged ≥65 years without dementia were followed up for a median of 5.0 years. Participants were categorized by spirometry as follows: normal spirometry (FEV<sub>1</sub>/FVC ≥0.70 and FEV<sub>1</sub> ≥80% predicted), PRISm (≥0.70 and <80%), airflow limitation (AFL) Global Initiative for Chronic Obstructive Lung Disease (GOLD) 1 (<0.70 and ≥80%), and AFL GOLD 2 to 4 (<0.70 and <80%). Hazard ratios (HRs) and their 95% confidence intervals (CIs) were computed using a Cox proportional hazards model.</p><p><b>Results:</b> During the follow-up period, 122 participants developed dementia. The age- and sex-adjusted incidences of dementia in the participants with normal spirometry, PRISm, AFL GOLD 1, and AFL GOLD 2 to 4 were 20.5, 37.0, 18.4, and 28.6 per 1,000 person-years, respectively. Participants with PRISm had a higher risk of dementia (HR 2.04; 95% CI, 1.19–3.49) than those with normal spirometry after adjusting for confounders. Moreover, both reduced FEV<sub>1</sub>% predicted values and FVC% predicted values were associated with the risk of dementia.</p><p><b>Conclusion:</b> PRISm was associated with an increased risk of dementia in a general older Japanese population.</p>

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  • Day-to-day home blood pressure variability and risk of atrial fibrillation in a general Japanese population: the Hisayama Study.

    Maezono A, Sakata S, Hata J, Oishi E, Furuta Y, Shibata M, Ide T, Kitazono T, Tsutsui H, Ninomiya T

    Eur J Prev Cardiol   31   1115 - 1122   2024.7

  • Risks of dementia in a general Japanese older population with preserved ratio impaired spirometry: the Hisayama Study.

    Kawatoko K, Washio Y, Ohara T, Fukuyama S, Honda T, Hata J, Nakazawa T, Kan-O K, Inoue H, Matsumoto K, Nakao T, Kitazono T, Okamoto I, Ninomiya T

    J Epidemiol   34   331 - 339   2024.7

  • Association between retinopathy and risk of dementia in a general Japanese population: the Hisayama Study.

    Nakamura S, Ueda E, Ohara T, Hata J, Honda T, Fujiwara K, Furuta Y, Shibata M, Hashimoto S, Nakazawa T, Nakao T, Kitazono T, Sonoda KH, Ninomiya T

    Sci Rep   14   12017,   2024.7

  • Association between masticatory function, frailty, and functional disability: an observational study. International journal

    Hiroko Furuhashi, Takanori Honda, Yoshihiko Furuta, Shoko Tomooka, Takahiro Tajimi, Yasumi Kimura, Daigo Yoshida, Toshiharu Ninomiya

    BMC geriatrics   24 ( 1 )   538 - 538   2024.6   eISSN:1471-2318

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    BACKGROUND: Increase in functional disability in aging societies is an international medical and public health issue. Masticatory function may be a potential risk factor for functional disability, but the role of frailty in the association has not been clarified. METHODS: Forty thousand five hundred sixty-two community-dwelling older adults aged 65 years and over who were insured by public health insurance as of April 2018 were followed up for a median of 3.0 years. Masticatory function was categorized as good, moderate, or poor based on a self-reported questionnaire. The development of functional disability was defined as a new certification of the need for long-term care. A Cox proportional hazards model was used to calculate hazard ratios (HRs) and their 95% confidence intervals (CIs). RESULTS: During the follow-up period, 1,397 individuals experienced functional disability. After adjusting for age, sex, comorbidities, medical history, and lifestyle behaviors, the HR for incident functional disability was significantly higher in the moderate and poor groups compared to the good group (moderate, HR 1.21 [95% CI, 1.07-1.37]; poor, HR 1.64 [95% CI, 1.03-2.62]). However, after additional adjustment for frailty-related factors-namely, underweight, regular exercise, and gait speed-the association was attenuated in both the moderate group (HR 1.06 [95% CI, 0.94-1.21]) and the poor group (HR 1.51 [95% CI, 0.94-2.41]). CONCLUSIONS: Masticatory dysfunction was significantly associated with incident functional disability in a community-dwelling older Japanese population. Our findings suggest that masticatory dysfunction may be a surrogate of frailty rather than a direct cause of functional disability.

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  • Association between masticatory function, frailty, and functional disability: an observational study.

    Furuhashi H, Honda T, Furuta Y, Tomooka S, Tajimi T, Kimura Y, Yoshida D, Ninomiya T

    BMC Geriatr   24   538   2024.6

  • Plasma biomarkers for predicting the development of dementia in a community-dwelling older Japanese population.

    Ohara T, Tatebe H, Hata J, Honda T, Shibata M, Matsuura S, Mikami T, Maeda T, Ono K, Mimura M, Nakashima K, Iga JI, Takebayashi M, Tokuda T, Ninomiya T; JPSC‐AD (Japan Prospective Studies Collaboration for Aging and Dementia) study group

    Psychiatry Clin Neurosci   78   362 - 371   2024.6

  • Plasma biomarkers for predicting the development of dementia in a community-dwelling older Japanese population. International journal

    Tomoyuki Ohara, Harutsugu Tatebe, Jun Hata, Takanori Honda, Mao Shibata, Sayo Matsuura, Tatsuya Mikami, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Takahiko Tokuda, Toshiharu Ninomiya

    Psychiatry and clinical neurosciences   78 ( 6 )   362 - 371   2024.6   ISSN:1323-1316 eISSN:1440-1819

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    AIM: To assess the association between plasma amyloid β (Aβ) 42/40, phosphorylated tau (p-τ)181, glial fibrillary acidic protein (GFAP), or neurofilament light chain (NfL) and the risk of dementia and to determine whether these plasma biomarkers could improve the ability to predict incident dementia in a general older population. METHODS: A total of 1346 Japanese community-dwelling individuals aged ≥65 years without dementia were followed prospectively for 5.0 years. Plasma biomarkers were quantified using a Simoa HD-X analyzer. A Cox proportional hazards model was used to estimate the hazard ratios of each plasma biomarker level for the risk of dementia. RESULTS: During the follow-up, 151 participants developed dementia, of whom 108 had Alzheimer disease (AD) and 43 non-Alzheimer dementia (non-AD). Lower plasma Aβ42/40 levels and higher plasma p-τ181 levels were significantly associated with developing AD but not non-AD, whereas significant associations were observed between higher plasma levels of GFAP and NfL and risk of both AD and non-AD (all P for trend <0.05). In addition, adding these four plasma biomarkers into a model consisting of the total score of the dementia risk model significantly improved the predictive ability for incident dementia. CONCLUSION: Our findings suggest that plasma Aβ42/40 and p-τ181 are specific markers of AD, and plasma GFAP and NfL are potential biomarkers for all-cause dementia in the general Japanese older population. In addition, the measurement of these plasma biomarkers may be a useful and relatively low-invasive procedure for identifying individuals at high risk for developing dementia in clinical practice.

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  • Descriptive epidemiology of muscle-strengthening activities in Japanese middle-aged and older adults: the Hisayama Study.

    Honda T, Hata J, Shibata M, Sakata S, Furuta Y, Oishi E, Kitazono T, Ninomiya T

    BMJ public health   2 ( 1 )   e000186   2024.6

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  • 地域在住日本人高齢者における認知症発症予測のための血漿バイオマーカー(Plasma biomarkers for predicting the development of dementia in a community-dwelling older Japanese population)

    Ohara Tomoyuki, Tatebe Harutsugu, Hata Jun, Honda Takanori, Shibata Mao, Matsuura Sayo, Mikami Tatsuya, Maeda Tetsuya, Ono Kenjiro, Mimura Masaru, Nakashima Kenji, Iga Jun-ichi, Takebayashi Minoru, Tokuda Takahiko, Ninomiya Toshiharu, JPSC-AD(Japan Prospective Studies Collaboration for Aging and Dementia) study group

    Psychiatry and Clinical Neurosciences   78 ( 5-6 )   362 - 371   2024.6   ISSN:1323-1316

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    血漿中Aβ42/40、リン酸化タウ(p-t181)、GFAP、ニューロフィラメント軽鎖(NfL)と認知症リスクとの関連を評価し、これらのバイオマーカーが認知症発症予測能を向上させるかどうか検討した。65歳以上の認知症でない地域在住日本人1346名を5年間前向きに追跡し、血漿バイオマーカーを測定した。Cox比例ハザードモデルを用いて、各バイオマーカーと認知症リスクとのハザード比を推定した。その結果、追跡期間中に151名が認知症を発症し、そのうち108名がアルツハイマー型認知症(AD)、3名が非アルツハイマー型認知症(non-AD)であった。低Aβ42/40および高p-t181はADリスクと有意に関連していたが、non-ADとは関連がなかった。GFAPおよびNfLはADおよびnon-ADのリスクの両方と有意に関連していた。これらのバイオマーカーを認知症リスクモデルに加えることで、発症予測精度が有意に向上した。以上の結果から、Aβ42/40およびp-t181はADの特異的マーカー、GFAPおよびNfLはall-cause dementiaの有力なバイオマーカーであり、これらの測定は臨床で認知症ハイリスク群の特定に有用であることが示唆された。

  • Association between retinopathy and risk of dementia in a general Japanese population: the Hisayama Study. International journal

    Shun Nakamura, Emi Ueda, Tomoyuki Ohara, Jun Hata, Takanori Honda, Kohta Fujiwara, Yoshihiko Furuta, Mao Shibata, Sawako Hashimoto, Taro Nakazawa, Tomohiro Nakao, Takanari Kitazono, Koh-Hei Sonoda, Toshiharu Ninomiya

    Scientific reports   14 ( 1 )   12017 - 12017   2024.5   ISSN:2045-2322

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    We investigated the association of retinopathy with the risk of dementia in a general older Japanese population. A total of 1709 population-based residents aged 60 years or older without dementia were followed prospectively for 10 years (2007-2017). They underwent color fundus photography in 2007. Retinopathy was graded according to the Modified Airlie House Classification. Main outcome was the Incidence of dementia. A Cox proportional hazards model was used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) for the risk of dementia by the presence of retinopathy. During the follow-up period, 374 participants developed all-cause dementia. The cumulative incidence of dementia was significantly higher in those with retinopathy than those without (p < 0.05). Individuals with retinopathy had significantly higher risk of developing dementia than those without after adjustment for potential confounding factors (HR 1.64, 95% CI 1.19-2.25). Regarding the components of retinopathy, the presence of microaneurysms was significantly associated with a higher multivariable-adjusted HR for incident dementia (HR 1.94, 95% CI 1.37-2.74). Our findings suggest that, in addition to systemic risk factors, retinal microvascular signs from fundus photography provide valuable information for estimating the risk of developing dementia.

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  • Association Between Serum NT-proBNP and Gray Matter Atrophy Patterns in an Older Japanese Population: The Hisayama Study. International journal

    Naoki Hirabayashi, Jun Hata, Yoshihiko Furuta, Taro Nakazawa, Tomoyuki Ohara, Mao Shibata, Fumio Yamashita, Takanari Kitazono, Nobuyuki Sudo, Toshiharu Ninomiya

    The journals of gerontology. Series A, Biological sciences and medical sciences   79 ( 5 )   2024.5   ISSN:1079-5006 eISSN:1758-535X

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    Several population-based studies have reported that higher serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels are associated with brain morphological changes. However, no population-based studies have examined the relationship between serum NT-proBNP and various regional brain volumes in detail. We here analyzed the brain MRI data of 1 201 community-dwelling Japanese aged ≥65 years. Regional gray matter volumes (GMV) and intracranial volume (ICV) were estimated by applying voxel-based morphometry (VBM) methods. The associations of serum NT-proBNP with regional GMV/ICV were examined by analysis of covariance. The regional gray matter atrophy patterns associated with elevated serum NT-proBNP levels were investigated using VBM without a priori regions of interest. The multivariable-adjusted means of the frontal, temporal, hippocampal, parahippocampal, and entorhinal GMV/ICV decreased significantly with elevated serum NT-proBNP levels (all p for trend and q values of false discovery rate correction < .05). In VBM, elevated serum NT-proBNP levels were correlated with atrophy of the bilateral hippocampi, bilateral amygdalas, bilateral parahippocampal gyri, bilateral entorhinal areas, bilateral fusiform gyri, left middle temporal gyrus, left inferior temporal gyrus, right central operculum, right posterior orbital gyrus, bilateral middle frontal gyri, anterior cingulate gyrus and bilateral medial frontal cortices. In a sensitivity analysis excluding 254 participants with mild cognitive impairment or dementia, serum NT-proBNP levels were correlated with atrophy of the bilateral hippocampi, bilateral amygdalas, bilateral parahippocampal gyri, bilateral fusiform gyri, and left middle frontal gyrus. Our data suggest that elevated serum NT-proBNP levels are associated with gray matter atrophy in brain regions that play an important role in cognitive function.

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  • Autonomic nervous system function assessed by heart rate variability and the presence of symptoms affecting activities of daily living in community-dwelling residents with chronic pain: the Hisayama Study.

    Nakamura Y, Shibata M, Morisaki Y, Hirabayashi N, Higashioka M, Hata J, Hosoi M, Sudo N, Yamaura K, Ninomiya T 

    Eur J Pain 28: 831-844, 2024   28   831 - 844   2024.5

  • Autonomic nervous system function assessed by heart rate variability and the presence of symptoms affecting activities of daily living in community-dwelling residents with chronic pain: The Hisayama Study. International journal

    Yuri Nakamura, Mao Shibata, Yukiko Morisaki, Naoki Hirabayashi, Mayu Higashioka, Jun Hata, Masako Hosoi, Nobuyuki Sudo, Ken Yamaura, Toshiharu Ninomiya

    European journal of pain (London, England)   28 ( 5 )   831 - 844   2024.5   ISSN:1090-3801 eISSN:1532-2149

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    BACKGROUND: Autonomic nervous system dysfunction has been reported to be associated with impaired activities of daily living (ADL) among patients with chronic pain, but the association has not been fully addressed in general populations. This study cross-sectionally investigated the association between autonomic nervous system function and the presence of subjective symptoms affecting ADL in community-dwelling residents with chronic pain. METHODS: A total of 888 residents with chronic pain, aged 40-79 years, who underwent a health examination in 2017-2018 were included. Based on heart rate variability measured by fingertip pulse wave, the standard deviation of normal-to-normal intervals (SDNN), root mean square of successive RR interval differences (RMSSD), low frequency (LF) power, and high frequency (HF) power were calculated. Symptoms affecting ADL were defined as those scoring ≥1 on the modified Rankin Scale. Odds ratios (ORs) and their 95% confidence intervals (CIs) for symptoms affecting ADL were estimated using a logistic regression analysis. RESULTS: The overall prevalence of symptoms affecting ADL was 39.4%. The ORs for symptoms affecting ADL increased significantly per 1-standard-deviation decrement in log-transformed SDNN (OR 1.23 [95% CI 1.06-1.44]), RMSSD (1.25 [1.08-1.45]), LF power (1.29 [1.11-1.52]), and HF power (1.29 [1.11-1.51]) after adjusting for age, sex, education, hypertension, diabetes, serum total cholesterol level, body mass index, past medical history, current smoking, current drinking, exercise, depressive symptoms, and pain intensity. CONCLUSIONS: Decreased heart rate variability was associated with the presence of symptoms affecting ADL among individuals with chronic pain in a Japanese community. SIGNIFICANCE: Decrease in heart rate variability was associated with the presence of symptoms affecting ADL among individuals with chronic pain in a Japanese community. This article could help scientists understand the significance of autonomic nervous system dysfunction in the pathology of chronic pain. Approaches that target autonomic nervous system dysfunction may be an option to relieve or prevent symptoms affecting ADL for chronic pain sufferers.

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  • Power-cycling degradation monitoring of an IGBT module with VCE(sat) measurement in continuous operation of a chopper circuit

    Hasegawa K., Hara K., Shishido N., Nakano S., Saito W., Ninomiya T.

    Power Electronic Devices and Components   7   2024.4

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    This paper presents a power-cycling degradation monitoring method of an IGBT module with a V<inf>CE(sat)</inf> sensing circuit and junction temperature prediction by a three-dimensional structure model. A chopper circuit was introduced to provide a continuous-current-conducting operation of the IGBT module. The V<inf>CE(sat)</inf> sensing circuit with a low-cost IoT platform “Leafony” was utilized to monitor the junction temperature of an IGBT chip, which transferred the measured signal as digital data, and thus obtained a higher noise immunity than an analog-based circuit. The junction temperature of IGBT chip in the power module was analyzed from the dissipated power of IGBT and the transient thermal impedance between the chips and the ambient. This analysis is effective not only to observe the degradation but also to estimate the thermal resistance. Comparing the temperature profile between experiment and prediction provides health condition of the IGBT model. Predicted thermal profiles agreed with measured ones with 10 % increase of thermal resistance, which was degraded by a power cycle tester. From these results, the proposed monitoring method is effective to detect the progress of power cycle degradation.

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  • Serum high-sensitivity C-reactive protein and dementia in a community-dwelling Japanese older population (JPSC-AD). International journal

    Ayumi Tachibana, Jun-Ichi Iga, Tomoki Ozaki, Taku Yoshida, Yuta Yoshino, Hideaki Shimizu, Takaaki Mori, Yoshihiko Furuta, Mao Shibata, Tomoyuki Ohara, Jun Hata, Yasuyuki Taki, Tatsuya Mikami, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Minoru Takebayashi, Toshiharu Ninomiya, Shu-Ichi Ueno

    Scientific reports   14 ( 1 )   7374 - 7374   2024.3   ISSN:2045-2322

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    In recent years, the association between neuroinflammatory markers and dementia, especially Alzheimer's disease (AD), has attracted much attention. However, the evidence for the relationship between serum-hs-CRP and dementia including AD are inconsistent. Therefore, the relationships of serum high-sensitivity CRP (hs-CRP) with dementia including AD and with regions of interest of brain MRI were investigated. A total of 11,957 community residents aged 65 years or older were recruited in eight sites in Japan (JPSC-AD Study). After applying exclusion criteria, 10,085 participants who underwent blood tests and health-related examinations were analyzed. Then, serum hs-CRP levels were classified according to clinical cutoff values, and odds ratios for the presence of all-cause dementia and its subtypes were calculated for each serum hs-CRP level. In addition, the association between serum hs-CRP and brain volume regions of interest was also examined using analysis of covariance with data from 8614 individuals in the same cohort who underwent brain MRI. After multivariable adjustment, the odds ratios (ORs) for all-cause dementia were 1.04 (95% confidence interval [CI] 0.76-1.43), 1.68 (95%CI 1.08-2.61), and 1.51 (95%CI 1.08-2.11) for 1.0-1.9 mg/L, 2.0-2.9 mg/L, and ≥ 3.0 mg/L, respectively, compared to < 1.0 mg/L, and those for AD were 0.72 (95%CI 0.48-1.08), 1.76 (95%CI 1.08-2.89), and 1.61 (95%CI 1.11-2.35), for 1.0-1.9 mg/L, 2.0-2.9 mg/L, and ≥ 3.0 mg/L, respectively, compared to < 1.0 mg/L. Multivariable-adjusted ORs for all-cause dementia and for AD prevalence increased significantly with increasing serum hs-CRP levels (p for trend < 0.001 and p = 0.001, respectively). In addition, the multivariable-adjusted temporal cortex volume/estimated total intracranial volume ratio decreased significantly with increasing serum hs-CRP levels (< 1.0 mg/L 4.28%, 1.0-1.9 mg/L 4.27%, 2.0-2.9 mg/L 4.29%, ≥ 3.0 mg/L 4.21%; p for trend = 0.004). This study's results suggest that elevated serum hs-CRP levels are associated with greater risk of presence of dementia, especially AD, and of temporal cortex atrophy in a community-dwelling Japanese older population.

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  • Brain atrophy in normal older adult links tooth loss and diet changes to future cognitive decline International journal

    Nakamura Hiroyuki, Noguchi-Shinohara Moeko, Ishimiya-Jokaji Mai, Kobayashi Yutaka, Isa Mikana, Ide Kentaro, Kawano Toshihiro, Kawashiri Shuichi, Uchida Kazuhiro, Tatewaki Yasuko, Taki Yasuyuki, Ohara Tomoyuki, Ninomiya Toshiharu, Ono Kenjiro

    NPJ Aging   10 ( 1 )   1 - 10   2024.3   eISSN:27316068

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    Several studies have found associations between poor oral health, particularly tooth loss and cognitivedecline. However, the specific brain regions affected by tooth loss and the probable causes remainunclear. We conducted a population-based longitudinal cohort study in Nakajima, Nanao City, Japan.Between 2016 and 2018, 2454 residents aged ≥60 participated, covering 92.9% of the local agedemographics. This study used comprehensive approach by combining detailed dental examinations,dietary assessments, magnetic resonance imaging (MRI) analysis, and cognitive evaluations. Toothloss, even in cognitively normal individuals, is associated with parahippocampal gyrus atrophy andincreased WMH volume, both of which are characteristics of dementia. Tooth loss was associatedwith altered dietary patterns, notably a reduction in plant-based food intake and an increase in fatty,processed food intake. This study highlights a possible preventative pathway where oral health mayplay a significant role in preventing the early neuropathological shifts associated with dementia.

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  • Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults.

    NCD Risk Factor Collaboration (NCD-RisC)( Ninomiya T, Hata J)

    Lancet   403   1027 - 1050   2024.3

  • Serum high-sensitivity C-reactive protein and dementia in a community-dwelling Japanese older population (JPSC-AD).

    Tachibana A, Iga JI, Ozaki T, Yoshida T, Yoshino Y, Shimizu H, Mori T, Furuta Y, Shibata M, Ohara T, Hata J, Taki Y, Mikami T, Maeda T, Ono K, Mimura M, Nakashima K, Takebayashi M, Ninomiya T, Ueno SI; JPSC-AD study group

    Sci Rep   14   7374   2024.3

  • Brain atrophy in normal older adult links tooth loss and diet changes to future cognitive decline.

    Nakamura H, Noguchi-Shinohara M, Ishimiya-Jokaji M, Kobayashi Y, Isa M, Ide K, Kawano T, Kawashiri S, Uchida K, Tatewaki Y, Taki Y, Ohara T, Ninomiya T, Ono K

    NPJ Aging   10   20   2024.3

  • Day-to-day home blood pressure variability and risk of atrial fibrillation in a general Japanese population: the Hisayama Study. International journal

    Akihiro Maezono, Satoko Sakata, Jun Hata, Emi Oishi, Yoshihiko Furuta, Mao Shibata, Tomomi Ide, Takanari Kitazono, Hiroyuki Tsutsui, Toshiharu Ninomiya

    European journal of preventive cardiology   31 ( 9 )   1115 - 1122   2024.2   ISSN:2047-4873 eISSN:2047-4881

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    AIMS: Several prospective studies have reported that higher visit-to-visit blood pressure variability (BPV) is associated with atrial fibrillation (AF). However, no studies have investigated the association between day-to-day BPV assessed by home blood pressure measurement and the development of AF. METHODS: A total of 2,827 community-dwelling Japanese aged ≥40 years without prior AF were followed up for 10 years (2007-2017). Day-to-day home BPV (defined as coefficients of variation [CoV] of home systolic blood pressure [SBP] for 28 days) were categorized into 4 groups according to the quartiles: Q1, ≤4.64%; Q2, 4.65%-5.70%; Q3, 5.71%-7.01%; Q4, ≥7.02%. The hazard ratios for developing AF were estimated using a Cox proportional hazards model. RESULTS: During the follow-up period, 134 participants developed new-onset AF. The crude incidence rates of AF increased significantly with higher CoV levels of home SBP: 2.1, 4.7, 5.3, and 8.8 per 1000 person-years in the first, second, third, and fourth quartiles, respectively (P for trend <0.01). After adjusting for potential confounders, increased CoV levels of home SBP were associated significantly with a higher risk of AF (P for trend =0.02). The participants in the highest quartile of CoV had a 2.18-fold (95% confidence intervals: 1.18-4.04) increased risk of developing AF compared to those in the lowest quartile. CONCLUSIONS: The present findings suggest that increased day-to-day home BPV levels are associated with a higher risk of the development of AF in a general Japanese population.

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  • Longitudinal association of sedentary time with diabetes mellitus and markers of glucose metabolism in middle-aged and older adults: the Hisayama Study. Invited Reviewed International journal

    Tsuda S, Honda T, Higashioka M, Hata J, Nakano T, Kitazono T, Ninomiya T

    J Diabetes Investig   15   245 - 246   2024.2

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  • Database profile of the Fukuoka-City Information Platform for Community-based Integrated Care. Invited Reviewed International journal

    Honda T, Furuhashi H, Furuta Y, Tomooka S, Tajimi T, Nagasawa F, Oishi E, Kimura Y, Yoshida D, Ninomiya T

    Annals of Clinical Epidemiology   6   5 - 11   2024.2

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  • Longitudinal association of sedentary time with diabetes mellitus and markers of glucose metabolism in middle-aged and older adults: The Hisayama Study.

    Susumu Tsuda, Takanori Honda, Mayu Higashioka, Jun Hata, Toshiaki Nakano, Takanari Kitazono, Toshiharu Ninomiya

    Journal of diabetes investigation   15 ( 2 )   245 - 246   2024.2   ISSN:2040-1116 eISSN:2040-1124

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  • 血清リポ多糖結合蛋白濃度とメタボリックシンドローム発症との関連 久山町研究(Serum Lipopolysaccharide-binding Protein Levels and the Incidence of Metabolic Syndrome in a General Japanese Population: the Hisayama Study)

    Tomooka Shoko, Oishi Emi, Asada Masako, Sakata Satoko, Hata Jun, Chen Sanmei, Honda Takanori, Suzuki Kosuke, Watanabe Hiroshi, Murayama Norihito, Wada Naohisa, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Epidemiology   34 ( 1-2 )   1 - 7   2024.2   ISSN:0917-5040

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    <Highlight>●本研究は、血清リポ多糖結合蛋白(LBP)値とメタボリックシンドローム(MetS)発症との関連を検討した最初の前向きコホート研究である。●血清LBP値の上昇に伴いメタボリックシンドロームおよびその構成要素の発症リスクは上昇した。●媒介解析において、HOMA-IRと血清高感度CRPは血清LBPとMetS発症との関連に、部分的に介在していた。●血清LBP値とメタボリックシンドロームの発症リスクの関連はインスリン抵抗性と慢性炎症を介した機序が示唆された。(著者抄録)

  • Role of Polyunsaturated Fat in Modifying Cardiovascular Risk Associated With Family History of Cardiovascular Disease: Pooled De Novo Results From 15 Observational Studies. International journal

    Federica Laguzzi, Agneta Åkesson, Matti Marklund, Frank Qian, Bruna Gigante, Traci M Bartz, Julie K Bassett, Anna Birukov, Hannia Campos, Yoichiro Hirakawa, Fumiaki Imamura, Susanne Jäger, Maria Lankinen, Rachel A Murphy, Mackenzie Senn, Toshiko Tanaka, Nathan Tintle, Jyrki K Virtanen, Kazumasa Yamagishi, Matthew Allison, Ingeborg A Brouwer, Ulf De Faire, Gudny Eiriksdottir, Luigi Ferrucci, Nita G Forouhi, Johanna M Geleijnse, Allison M Hodge, Hitomi Kimura, Markku Laakso, Ulf Risérus, Anniek C van Westing, Stefania Bandinelli, Ana Baylin, Graham G Giles, Vilmundur Gudnason, Hiroyasu Iso, Rozenn N Lemaitre, Toshiharu Ninomiya, Wendy S Post, Bruce M Psaty, Jukka T Salonen, Matthias B Schulze, Michael Y Tsai, Matti Uusitupa, Nicholas J Wareham, Seung-Won Oh, Alexis C Wood, William S Harris, David Siscovick, Dariush Mozaffarian, Karin Leander

    Circulation   149 ( 4 )   305 - 316   2024.1   ISSN:0009-7322 eISSN:1524-4539

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    BACKGROUND: It is unknown whether dietary intake of polyunsaturated fatty acids (PUFA) modifies the cardiovascular disease (CVD) risk associated with a family history of CVD. We assessed interactions between biomarkers of low PUFA intake and a family history in relation to long-term CVD risk in a large consortium. METHODS: Blood and tissue PUFA data from 40 885 CVD-free adults were assessed. PUFA levels ≤25th percentile were considered to reflect low intake of linoleic, alpha-linolenic, and eicosapentaenoic/docosahexaenoic acids (EPA/DHA). Family history was defined as having ≥1 first-degree relative who experienced a CVD event. Relative risks with 95% CI of CVD were estimated using Cox regression and meta-analyzed. Interactions were assessed by analyzing product terms and calculating relative excess risk due to interaction. RESULTS: After multivariable adjustments, a significant interaction between low EPA/DHA and family history was observed (product term pooled RR, 1.09 [95% CI, 1.02-1.16]; P=0.01). The pooled relative risk of CVD associated with the combined exposure to low EPA/DHA, and family history was 1.41 (95% CI, 1.30-1.54), whereas it was 1.25 (95% CI, 1.16-1.33) for family history alone and 1.06 (95% CI, 0.98-1.14) for EPA/DHA alone, compared with those with neither exposure. The relative excess risk due to interaction results indicated no interactions. CONCLUSIONS: A significant interaction between biomarkers of low EPA/DHA intake, but not the other PUFA, and a family history was observed. This novel finding might suggest a need to emphasize the benefit of consuming oily fish for individuals with a family history of CVD.

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  • Serum Lipopolysaccharide-binding Protein Levels and the Incidence of Metabolic Syndrome in a General Japanese Population: the Hisayama Study

    Tomooka Shoko, Oishi Emi, Asada Masako, Sakata Satoko, Hata Jun, Chen Sanmei, Honda Takanori, Suzuki Kosuke, Watanabe Hiroshi, Murayama Norihito, Wada Naohisa, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Epidemiology   34 ( 1 )   1 - 7   2024.1   ISSN:09175040 eISSN:13499092

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    <p><b>Background:</b> The association between chronic lipopolysaccharide exposure and the development of metabolic syndrome (MetS) is unclear. In this study we examined the association between serum lipopolysaccharide-binding protein (LBP) levels, an indicator of lipopolysaccharide exposure, and the development of MetS in a general Japanese population.</p><p><b>Methods:</b> 1,869 community-dwelling Japanese individuals aged ≥40 years without MetS at baseline examination in 2002–2003 were followed up by repeated examination in 2007–2008. MetS was defined according to the Japanese criteria. Serum LBP levels were classified into quartiles (quartiles 1–4: 2.20–9.56, 9.57–10.78, 10.79–12.18, and 12.19–24.34 µg/mL, respectively). Odds ratios (ORs) for developing MetS were calculated using a logistic regression model.</p><p><b>Results:</b> At the follow-up survey, 159 participants had developed MetS. Higher serum LBP levels were associated with greater risk of developing MetS after multivariable adjustment for age, sex, smoking, drinking, and exercise habits (OR [95% confidence interval] for quartiles 1–4: 1.00 [reference], 2.92 [1.59–5.37], 3.48 [1.91–6.35], and 3.86 [2.12–7.03], respectively; <i>P</i> for trend <0.001). After additional adjustment for homeostasis model assessment of insulin resistance, this association was attenuated but remained significant (<i>P</i> for trend = 0.007). On the other hand, no significant association was observed after additional adjustment for serum high-sensitivity C-reactive protein (<i>P</i> for trend = 0.07).</p><p><b>Conclusion:</b> In the general Japanese population, our findings suggest that higher serum LBP levels are associated with elevated risk of developing MetS. Low-grade endotoxemia could play a role in the development of MetS through systemic chronic inflammation and insulin resistance.</p>

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  • Serum lipopolysaccharide-binding protein levels and the incidence of metabolic syndrome in a general Japanese population: the Hisayama Study. Invited Reviewed International journal

    Tomooka S, Oishi E, Asada M, Sakata S, Hata J, Chen S, Honda T, Suzuki K, Watanabe H, Murayama N, Wada N, Kitazono T, Ninomiya T

    J Epidemiol   1 - 7   2024.1

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  • Late-Life high blood pressure and enlarged perivascular spaces in the putaminal regions of community-dwelling Japanese older persons.

    Tachibana A, Iga JI, Tatewaki Y, Thyreau B, Chen H, Ozaki T, Yoshida T, Yoshino Y, Shimizu H, Mori T, Furuta Y, Shibata M, Ohara T, Hata J, Taki Y, Nakaji S, Maeda T, Ono K, Mimura M, Nakashima K, Takebayashi M, Ninomiya T, Ueno SI; JPSC-AD study group

    J Geriatr Psychiatry Neurol   37   61 - 72   2024.1

  • Role of polyunsaturated fat in modifying cardiovascular risk associated with family history of cardiovascular disease: pooled de novo results from 15 observational studies

    Laguzzi F, Åkesson A, Marklund M, Qian F, Gigante B, Bartz TM, Bassett JK, Birukov A, Campos H, Hirakawa Y, Imamura F, Jäger S, Lankinen M, Murphy RA, Senn M, Tanaka T, Tintle N, Virtanen JK, Yamagishi K, Allison M, Brouwer IA, De Faire U, Eiriksdottir G, Ferrucci L, Forouhi NG, Geleijnse JM, Hodge AM, Kimura H, Laakso M, Risérus U, van Westing AC, Bandinelli S, Baylin A, Giles GG, Gudnason V, Iso H, Lemaitre RN, Ninomiya T, Post WS, Psaty BM, Salonen JT, Schulze MB, Tsai MY, Uusitupa M, Wareham NJ, Oh SW, Wood AC, Harris WS, Siscovick D, Mozaffarian D, Leander K; Fatty Acids and Outcomes Research Consortium (FORCE)

    Circulation   149   305 - 316   2024.1

  • Omega-3 blood levels and stroke risk: a pooled and harmonized analysis of 183 291 participants from 29 prospective studies.

    O'Keefe JH, Tintle NL, Harris WS, O'Keefe EL, Sala-Vila A, Attia J, Garg GM, Hure A, Bork CS, Schmidt EB, Venø SK, Chien KL, Chen YA, Egert S, Feldreich TR, Ärnlöv J, Lind L, Forouhi NG, Geleijnse JM, Pertiwi K, Imamura F, de Mello Laaksonen V, Uusitupa WM, Tuomilehto J, Laakso M, Lankinen MA, Laurin D, Carmichael PH, Lindsay J, Leander K, Laguzzi F, Swenson BR, Longstreth WT, Manson JE, Mora S, Cook NR, Marklund M, Melo van Lent D, Murphy R, Gudnason V, Ninomiya T, Hirakawa Y, Qian F, Sun Q, Hu F, Ardisson Korat AV, Risérus U, Lázaro I, Samieri C, Le Goff M, Helmer C, Steur M, Voortman T, Ikram MK, Tanaka T, Das JK, Ferrucci L, Bandinelli S, Tsai M, Guan W, Garg P, Verschuren WMM, Boer JMA, Biokstra A, Virtanen J, Wagner M, Westra J, Albuisson L, Yamagishi K, Siscovick DS, Lemaitre RN, Mozaffarian D

    Stroke   55   50 - 58   2024.1

  • Late-Life High Blood Pressure and Enlarged Perivascular Spaces in the Putaminal Regions of Community-Dwelling Japanese Older Persons. International journal

    Ayumi Tachibana, Jun-Ichi Iga, Yasuko Tatewaki, Benjamin Thyreau, Hongkun Chen, Tomoki Ozaki, Taku Yoshida, Yuta Yoshino, Hideaki Shimizu, Takaaki Mori, Yoshihiko Furuta, Mao Shibata, Tomoyuki Ohara, Jun Hata, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Minoru Takebayashi, Toshiharu Ninomiya, Shu-Ichi Ueno

    Journal of geriatric psychiatry and neurology   37 ( 1 )   61 - 72   2024.1   ISSN:0891-9887 eISSN:1552-5708

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    BACKGROUND: Enlarged perivascular spaces (EPVS) of the brain may be involved in dementia, such as Alzheimer's disease and cerebral small vessel disease (CSVD). Hypertension has been reported to be a risk factor for dementia and CSVD, but the association between blood pressure (BP) and perivascular spaces is still unclear. The aim of this study was to determine the association between BP and EPVS volumes and to examine the interactions of relevant factors. METHODS: A total of 9296 community-dwelling subjects aged ≥65 years participated in a brain magnetic resonance imaging and health status screening examination. Perivascular volume was measured using a software package based on deep learning that was developed in-house. The associations between BP and EPVS volumes were examined by analysis of covariance and multiple regression analysis. RESULTS: Mean EPVS volumes increased significantly with rising systolic and diastolic BP levels (P for trend = .003, P for trend<.001, respectively). In addition, mean EPVS volumes increased significantly for every 1-mmHg-increment in systolic and diastolic BPs (both P values <.001). These significant associations were still observed in the sensitivity analysis after excluding subjects with dementia. CONCLUSIONS: The present data suggest that higher systolic and diastolic BP levels are associated with greater EPVS volumes in cognitively normal older people.

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  • Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies

    O'Keefe, JH; Tintle, NL; Harris, WS; O'Keefe, EL; Sala-Vila, A; Attia, J; Garg, GM; Hure, A; Bork, CS; Schmidt, EB; Veno, SK; Chien, KL; Chen, YY; Egert, S; Feldreich, TR; Arnlöv, J; Lind, L; Forouhi, NG; Geleijnse, JM; Pertiwi, K; Imamura, F; Laaksonen, VD; Uusitupa, WM; Tuomilehto, J; Laakso, M; Lankinen, MA; Laurin, D; Carmichael, PH; Lindsay, J; Leander, K; Laguzzi, F; Swenson, BR; Longstreth, WT; Manson, JE; Mora, S; Cook, NR; Marklund, M; van Lent, DM; Murphy, R; Gudnason, V; Ninomiya, T; Hirakawa, Y; Qian, F; Sun, Q; Hu, F; Korat, AVA; Risérus, U; Lázaro, I; Samieri, C; Le Goff, M; Helmer, C; Steur, M; Voortman, T; Ikram, MK; Tanaka, T; Das, JK; Ferrucci, L; Bandinelli, S; Tsai, MC; Guan, WH; Garg, P; Verschuren, WMM; Boer, JMA; Biokstra, A; Virtanen, J; Wagner, M; Westra, J; Albuisson, L; Yamagishi, K; Siscovick, DS; Lemaitre, RN; Mozaffarian, D

    STROKE   55 ( 1 )   50 - 58   2024.1   ISSN:0039-2499 eISSN:1524-4628

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    BACKGROUND: The effect of marine omega-3 PUFAs on risk of stroke remains unclear. METHODS: We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts. Each site conducted a de novo individual-level analysis using a prespecified analytical protocol with defined exposures, covariates, analytical methods, and outcomes; the harmonized data from the studies were then centrally pooled. Multivariable-adjusted HRs and 95% CIs across omega-3 PUFA quintiles were computed for each stroke outcome. RESULTS: Among 183 291 study participants, there were 10 561 total strokes, 8220 ischemic strokes, and 1142 hemorrhagic strokes recorded over a median of 14.3 years follow-up. For eicosapentaenoic acid, comparing quintile 5 (Q5, highest) with quintile 1 (Q1, lowest), total stroke incidence was 17% lower (HR, 0.83 [CI, 0.76-0.91]; P<0.0001), and ischemic stroke was 18% lower (HR, 0.82 [CI, 0.74-0.91]; P<0.0001). For docosahexaenoic acid, comparing Q5 with Q1, there was a 12% lower incidence of total stroke (HR, 0.88 [CI, 0.81-0.96]; P=0.0001) and a 14% lower incidence of ischemic stroke (HR, 0.86 [CI, 0.78-0.95]; P=0.0001). Neither eicosapentaenoic acid nor docosahexaenoic acid was associated with a risk for hemorrhagic stroke. These associations were not modified by either baseline history of AF or prevalent CVD. CONCLUSIONS: Higher omega-3 PUFA levels are associated with lower risks of total and ischemic stroke but have no association with hemorrhagic stroke.

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  • 全国の一般地域住民における最近の循環器疾患発症率 NIPPON DATA2010

    門田 文, 大久保 孝義, 原田 亜紀子, 高嶋 直敬, 有馬 久富, 二宮 利治, 秦 淳, 寳澤 篤, 中村 幸志, 東山 綾, 大澤 正樹, 久松 隆史, 鳥居 さゆ希, 岡見 雪子, 近藤 慶子, 宮本 恵宏, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之

    Journal of Epidemiology   34 ( Suppl. )   122 - 122   2024.1   ISSN:0917-5040 eISSN:1349-9092

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  • 全国の一般地域住民における最近の循環器疾患発症率 NIPPON DATA2010

    門田 文, 大久保 孝義, 原田 亜紀子, 高嶋 直敬, 有馬 久富, 二宮 利治, 秦 淳, 寳澤 篤, 中村 幸志, 東山 綾, 大澤 正樹, 久松 隆史, 鳥居 さゆ希, 岡見 雪子, 近藤 慶子, 宮本 恵宏, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之

    Journal of Epidemiology   34 ( Suppl. )   122 - 122   2024.1   ISSN:0917-5040 eISSN:1349-9092

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  • Database profile of the Fukuoka-City Information Platform for Community-based Integrated Care

    Honda Takanori, Furuhashi Hiroko, Furuta Yoshihiko, Tomooka Shoko, Tajimi Takahiro, Nagasawa Fumi, Oishi Emi, Kimura Yasumi, Yoshida Daigo, Ninomiya Toshiharu

    Annals of Clinical Epidemiology   6 ( 1 )   5 - 11   2024   eISSN:24344338

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    <p><b>BACKGROUND</b></p><p>The Fukuoka-City Information Platform for Community-based Integrated Care is an advanced big data platform that aggregates information on the health and medical services of Fukuoka citizens. Fukuoka City is engaged in a joint project with Kyushu University to promote policy making through a large-scale real-world data analysis. This paper describes the framework for this cooperative effort and the features of the analytical platform.</p><p><b>METHODS</b></p><p>Fukuoka City is the fifth most populous ordinance-designated city in Japan, with an estimated population of approximately 1.6 million. Under an agreement with Fukuoka City, Kyushu University was granted access to a portion of the city’s anonymized healthcare database as secondary-use information. The database contains information on resident registration, health insurance claims, specific health checkups and health checkups for the older adults, specific health guidance, long-term care insurance data, and cancer screenings collected after fiscal year 2012. Each of these constituent datasets can be interlinked using anonymized hashed key variables, allowing individuals to be followed across databases and over time.</p><p><b>CONCLUSIONS</b></p><p>The platform allows longitudinal investigation of the complex association between various aspects of healthcare, such as medical procedures, examinations, interviews, medical costs, long-term care certifications, and care costs. The platform can provide valuable public-health information because it is relatively large for a single database, and because it allows analysis of data across multiple domains and tracing of individuals over time.</p>

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  • 認知症の予防・治療法を目指した本邦のコホート研究 司会の言葉

    二宮 利治

    Neurological Therapeutics   41 ( 4 )   532 - 532   2024   ISSN:09168443 eISSN:21897824

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    DOI: 10.15082/jsnt.41.4_532

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  • 認知症の地域疫学研究:久山町研究

    Ninomiya Toshiharu

    Neurological Therapeutics   41 ( 4 )   533 - 533   2024   ISSN:09168443 eISSN:21897824

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    DOI: 10.15082/jsnt.41.4_533

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  • 第5土曜特集 アルツハイマー病--研究と治療の最前線 予防・疫学 認知症の地域疫学研究の知見

    二宮 利治

    医学のあゆみ   287 ( 13 )   1002 - 1008   2023.12   ISSN:00392359

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    DOI: 10.32118/ayu287131002

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  • Effects of treatment with corticosteroids on human rhinovirus-induced asthma exacerbations in pediatric inpatients: a prospective observational study

    Kan-o, K; Washio, Y; Oki, T; Fujimoto, T; Ninomiya, T; Yoshida, M; Fujita, M; Nakanishi, Y; Matsumoto, K

    BMC PULMONARY MEDICINE   23 ( 1 )   487   2023.12   ISSN:1471-2466

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    Background: Human rhinoviruses (HRVs) infection is a common cause of exacerbations in pediatric patients with asthma. However, the effects of corticosteroids on HRV-induced exacerbations in pediatric asthma are unknown. We conducted a prospective observational study to determine the viral pathogens in school-age pediatric inpatients with asthma exacerbations. We assessed the effects of maintenance inhaled corticosteroids (ICS) on the detection rates of HRV species and treatment periods of systemic corticosteroids during exacerbations on pulmonary lung function after exacerbations. Methods: Nasopharyngeal samples and clinical information were collected from 59 patients with asthma exacerbations between April 2018 and March 2020. Pulmonary function tests were carried out 3 months after exacerbations in 18 HRV-positive patients. Changes in forced expiratory volume in 1 second (FEV<inf>1</inf>)% predicted from baseline in a stable state were compared according to the treatment periods of systemic corticosteroids. Results: Fifty-four samples collected from hospitalized patients were analyzed, and viral pathogens were identified in 45 patients (83.3%) using multiplex PCR assay. HRV-A, −B, and -C were detected in 16 (29.6%), one (1.9%), and 16 (29.6%) patients, respectively. The detection rates of HRV-C were lower in the ICS-treated group compared with those in the ICS-untreated group (p = 0.01), whereas maintenance ICS treatment did not affect the detection rate for viral pathogens in total and HRV-A. Changes in FEV<inf>1</inf>% predicted in patients treated with systemic corticosteroids for 6–8 days (n = 10; median, 4.90%) were higher than those in patients treated for 3–5 days (n = 8; median, − 10.25%) (p = 0.0085). Conclusions: Maintenance ICS reduced the detection rates of HRV (mainly HRV-C) in school-age inpatients with asthma exacerbations, and the treatment periods of systemic corticosteroids during exacerbations affected lung function after HRV-induced exacerbations. The protective effects of corticosteroids on virus-induced asthma exacerbations may be dependent upon the types of viral pathogen.

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  • Development and Validation of a Risk Prediction Model for Atherosclerotic Cardiovascular Disease in Japanese Adults: The Hisayama Study.

    Takanori Honda, Sanmei Chen, Jun Hata, Daigo Yoshida, Yoichiro Hirakawa, Yoshihiko Furuta, Mao Shibata, Satoko Sakata, Takanari Kitazono, Toshiharu Ninomiya

    Journal of atherosclerosis and thrombosis   30 ( 12 )   1966 - 1967   2023.12

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  • Association between choroidal thickness and myopic maculopathy in a Japanese population: the Hisayama Study International journal

    Emi Ueda, Miho Yasuda, Kohta Fujiwara, Sawako Hashimoto, Takanori Honda, Shun Nakamura, Jun Hata, Toshiharu Ninomiya, Koh-Hei Sonoda

    Ophthalmology Science   3 ( 4 )   100350 - 100350   2023.12   ISSN:2666-9145

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    PURPOSE: To examine the association between choroidal thickness and myopic maculopathy in a general Japanese population. DESIGN: Population-based cross-sectional study. PARTICIPANTS: A total of 2841 residents of a Japanese community aged ≥ 40 years, who consented to participate and had available data of choroidal thickness and fundus photographs, were enrolled in this study. METHODS: The choroidal thickness was measured by swept-source OCT. Participants were divided into quartiles of choroidal thickness. Myopic maculopathy was defined according to the classification system of the Meta-analysis of Pathologic Myopia Study Group. Main outcome measures were odds ratios (ORs) of choroidal thickness for prevalent myopic maculopathy. The ORs and 95% confidence intervals (CIs) were estimated using a logistic regression model. MAIN OUTCOME MEASURES: Prevalent myopic maculopathy. RESULTS: Eighty-one participants had myopic maculopathy (45 diffuse chorioretinal atrophy, 31 patchy chorioretinal atrophy, and 5 macular atrophy). Individuals in the lowest quartile of choroidal thickness had a significantly greater OR for the presence of myopic maculopathy than those in the highest quartile of choroidal thickness (OR: 4.78 [95% CI: 1.78-16.72]) after adjusting for confounders, including axial length. The sensitivity analysis among the 1176 myopic individuals with axial length of ≥ 24.0 mm also showed that thinner choroidal thickness was significantly associated with prevalent myopic maculopathy. CONCLUSIONS: The present study demonstrated the significant inverse association between choroidal thickness and the likelihood of myopic maculopathy, suggesting that the measurement of choroidal thickness in addition to axial length would be useful for assessing the risk of myopic maculopathy and elucidating its pathogenesis. FINANCIAL DISCLOSURES: Proprietary or commercial disclosure may be found after the references.

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  • Seasonal variations in renal biopsy numbers and primary glomerular disease features based on the Japan renal biopsy registry

    Kanzaki G., Tsuboi N., Yokoo T., Uesugi N., Furuichi K., Shimizu A., Sugiyama H., Sato H., Yokoyama H., Kitamura H., Katafuchi R., Nishi S., Hattori M., Yamamoto R., Ninomiya T., Ueda Y., Nagata M., Makino H., Kagami S.

    Scientific Reports   13 ( 1 )   2023.12

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    We analyzed the seasonal variations in the number of renal biopsies and clinical characteristics of primary glomerular disease in Japan using the Japan Renal Biopsy Registry (J-RBR). We retrospectively collected clinical and pathological data of patients with primary glomerular disease who were registered in the J-RBR between 2007 and 2018. Immunoglobulin A nephropathy (IgAN), minimal change nephrotic syndrome (MCNS), membranous nephropathy (MN), and postinfectious acute glomerulonephritis (PIAGN) constituted the four major glomerular disorders included in this study (total, 13,989; IgAN, 9121; MCNS, 2298; MN, 2447; and PIAGN, 123). The number of patients with IgAN or MCNS was higher during summer. However, no overt seasonal variations were observed in patients with MN or PIAGN. Subgroup analyses suggested that in the patients with IgAN, more renal biopsies of severe cases were performed during winter, probably owing to age and blood pressure. Furthermore, more renal biopsies of severe cases were performed during spring and winter in patients with MCNS even after adjusting for the abovementioned host factors. This study suggests that seasonal factors influence the decision to perform renal biopsy as well as the pathogenesis of primary glomerular disease. Thus, our findings may provide important insights regarding the pathophysiology of primary glomerular disease.

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  • Correction: Inadequate care and excessive overprotection during childhood are associated with the presence of Diabetes Mellitus in adulthood in a general Japanese population: a cross-sectional analysis from the Hisayama Study. International journal

    Mao Shibata, Masako Hosoi, Kozo Anno, Naoki Hirabayashi, Yoichiro Hirakawa, Hiroshi Kawata, Rie Iwaki, Ryoko Sawamoto, Nobuyuki Sudo, Toshiharu Ninomiya

    BMC endocrine disorders   23 ( 1 )   253 - 253   2023.11   eISSN:1472-6823

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    Following publication of the original article [1], the authors reported an error in the number of participants in Fig. 2. The original Fig. 2 was: The updated Fig. 2 should read: The original article [1] has been updated.

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  • Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c. Invited Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC)(Hata J, Ninomiya T)

    Nat Med   29   2885 - 2901   2023.11

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  • Gender and age influence the association between gait speed and mild cognitive impairment in community-dwelling Japanese older adults: from the Japan Prospective Studies Collaboration for Ageing and Dementia (JPSC-AD). Invited Reviewed International journal

    Bun S, Suzuki K, Niimura H, Shikimoto R, Kida H, Shibata M, Honda T, Ohara T, Hata J, Nakaji S, Maeda T, Ono K, Nakashima K, Iga JI, Takebayashi M, Ninomiya T, Mimura M; JPSC-AD Study Group

    Psychogeriatrics   23   918 - 929   2023.11

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  • n-6 fatty acid biomarkers and incident atrial fibrillation: an individual participant-level pooled analysis of 11 international prospective studies. Invited Reviewed International journal

    Garg PK, Guan W, Nomura S, Weir NL, Tintle N, Virtanen JK, Hirakawa Y, Qian F, Sun Q, Rimm E, Lemaitre RN, Jensen PN, Heckbert SR, Imamura F, Steur M, Leander K, Laguzzi F, Voortman T, Ninomiya T, Mozaffarian D, Harris WS, Siscovick DS, Tsai MY; Fatty Aci

    Am J Clin Nutr   118   921 - 929   2023.11

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  • Gender and age influence the association between gait speed and mild cognitive impairment in community‐dwelling Japanese older adults: from the Japan Prospective Studies Collaboration for Ageing and Dementia (<scp>JPSC‐AD</scp>) International journal

    Shogyoku Bun, Kouta Suzuki, Hidehito Niimura, Ryo Shikimoto, Hisashi Kida, Mao Shibata, Takanori Honda, Tomoyuki Ohara, Jun Hata, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Kenji Nakashima, Jun‐ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya, Masaru Mimura

    Psychogeriatrics   23 ( 6 )   918 - 929   2023.11   ISSN:1346-3500 eISSN:1479-8301

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    Background

    Studies have shown that decreased gait speed is associated with impaired cognitive function. However, whether this association is equivalent across ages or genders in the older population remains unclear. Thus, we examined the association between mild cognitive impairment (MCI) and gait speed emphasising the influence of age and gender.

    Methods

    Overall, 8233 Japanese participants aged ≥65 years were enrolled in this cross‐sectional study between 2016 and 2018. After stratification by gender and age group, the participants' gait speeds were divided into quintiles, and the difference in MCI prevalence at each gait speed quintile was calculated. Logistic regression analyses were performed to assess the odds of MCI for each quintile and to assess the influence of age and gender.

    Results

    Males had a consistently higher prevalence of MCI than females. The odds of MCI were increased as gait speed decreased. Logistic regression analyses revealed that in the multivariable‐adjusted model 2, the odds ratios (95% confidence interval; CI) for MCI were 2.02 (1.47–2.76) for females and 1.75 (1.29–2.38) for males in the slowest gait speed quintiles compared to the fastest quintile. In the stratified analyses, only males showed an age‐dependent increase in the associations between gait speed and MCI, while females exhibited comparable associations across age groups.

    Conclusions

    Reduced gait speed was associated with increased odds of MCI, and this association may vary according to gender and age. Therefore, gait speed could serve as a valuable screening tool for MCI, with gender‐ and age‐dependent clinical implications.

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  • n-6 fatty acid biomarkers and incident atrial fibrillation: an individual participant-level pooled analysis of 11 international prospective studies. International journal

    Parveen K Garg, Weihua Guan, Sarah Nomura, Natalie L Weir, Nathan Tintle, Jyrki K Virtanen, Yoichiro Hirakawa, Frank Qian, Qi Sun, Eric Rimm, Rozenn N Lemaitre, Paul N Jensen, Susan R Heckbert, Fumiaki Imamura, Marinka Steur, Karin Leander, Federica Laguzzi, Trudy Voortman, Toshiharu Ninomiya, Dariush Mozaffarian, William S Harris, David S Siscovick, Michael Y Tsai

    The American journal of clinical nutrition   118 ( 5 )   921 - 929   2023.11   ISSN:0002-9165 eISSN:1938-3207

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    BACKGROUND: The presence of atrial fibrillation (AF) is associated with an over 2-fold increased risk of stroke, heart failure, and cardiovascular mortality. Long chain n-6 PUFAs have been suggested to have a variety of beneficial biologic effects that may reduce AF development; however, prior studies evaluating this relationship are limited. OBJECTIVES: We prospectively evaluated the association between circulating levels of linoleic acid (LA) and arachidonic acid (AA) with incident AF. METHODS: We used participant-level data from a global consortium of 11 prospective cohort studies with measurements of LA and AA in adults (aged ≥18 y). Participating studies conducted de novo analyses using a prespecified analytical plan with harmonized definitions for exposures, outcomes, covariates, and subgroups. Associations were pooled using inverse-variance weighted meta-analysis. RESULTS: Among 41,335 participants, 6173 incident cases of AF were ascertained, with median follow-up time of 14 y. In multivariable analysis, per interquintile range (difference between the 10th and 90th percentiles for each fatty acid), circulating n-6 levels were not associated with incident AF. For LA, the hazard ratio per interquintile range was 0.96 (95% confidence interval [CI]: 0.89, 1.04), and for AA, 1.02 (95% CI: 0.94, 1.10), with little evidence of heterogeneity between cohorts. Associations were similarly nonsignificant across subgroups of age, race, and biomarker fraction. CONCLUSIONS: Biomarkers of n-6 fatty acids including LA and AA are not associated with incident AF. These findings suggest that overall effects of n-6 PUFAs on influencing AF development are neutral.

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  • Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

    Zhou, B; Sheffer, KE; Bennett, JE; Gregg, EW; Danaei, G; Singleton, RK; Shaw, JE; Mishra, A; Lhoste, VPF; Carrillo-Larco, RM; Kengne, AP; Phelps, NH; Heap, RA; Rayner, AW; Stevens, GA; Paciorek, CJ; Riley, LM; Cowan, MJ; Savin, S; Vander Hoorn, S; Lu, Y; Pavkov, ME; Imperatore, G; Aguilar-Salinas, CA; Ahmad, NA; Anjana, RM; Davletov, K; Farzadfar, F; González-Villalpando, C; Khang, YH; Kim, HC; Laatikainen, T; Laxmaiah, A; Mbanya, JCN; Narayan, KMV; Ramachandran, A; Wade, AN; Zdrojewski, T; Abbasi-Kangevari, M; Rahim, HFA; Abu-Rmeileh, NM; Adambekov, S; Adams, RJ; Aekplakorn, W; Agdeppa, IA; Aghazadeh-Attari, J; Agyemang, C; Ahmadi, A; Ahmadi, N; Ahmadi, N; Ahmed, SH; Ajlouni, K; Al-Hinai, H; Al-Lahou, B; Al-Lawati, JA; Al Asfoor, D; Al Qaoud, NM; Alarouj, M; AlBuhairan, F; AlDhukair, S; Aldwairji, MA; Ali, MM; Alinezhad, F; Alkandari, A; Alomirah, HF; Aly, E; Amarapurkar, DN; Andersen, LB; Anderssen, SA; Andrade, DS; Ansari-Moghaddam, A; Aounallah-Skhiri, H; Aris, T; Arlappa, N; Aryal, KK; Assah, FK; Assembekov, B; Auvinen, J; Avdicová, M; Azad, K; Azimi-Nezhad, M; Azizi, F; Bacopoulou, F; Balakrishna, N; Bamoshmoosh, M; Banach, M; Bandosz, P; Banegas, JR; Barbagallo, CM; Barceló, A; Baretic, M; Barrera, L; Basit, A; Batieha, AM; Batista, AP; Baur, LA; Belavendra, A; Ben Romdhane, H; Benet, M; Berkinbayev, S; Bernabe-Ortiz, A; Carrasola, XB; Bettiol, H; Beybey, AF; Bhargava, SK; Lele, ECB; Bikbov, MM; Bista, B; Bjerregaard, P; Bjertness, E; Bjertness, MB; Björkelund, C; Bloch, K; Blokstra, A; Bo, S; Bobak, M; Boggia, JG; Bonaccio, M; Bonilla-Vargas, A; Borghs, H; Bovet, P; Brajkovich, I; Brenner, H; Brewster, LM; Brian, GR; Briceño, Y; Brito, M; Bugge, A; Buntinx, F; de León, AC; Caixeta, RB; Can, G; Cândido, APC; Capanzana, M; Capková, N; Capuano, E; Capuano, R; Capuano, V; Cardoso, VC; Carlsson, AC; Casanueva, FF; Censi, L; Cervantes-Loaiza, M; Chamnan, P; Chamukuttan, S; Chan, Q; Charchar, FJ; Chaturvedi, N; Chen, HS; Cheraghian, B; Chirlaque, MD; Chudek, J; Cifkova, R; Cirillo, M; Claessens, F; Cohen, E; Concin, H; Cooper, C; Costanzo, S; Cowell, C; Crujeiras, AB; Cruz, JJ; Cureau, F; Cuschieri, S; D'Arrigo, G; D'Orsi, E; Dallongeville, J; Damasceno, A; Dastgiri, S; De Curtis, A; de Gaetano, G; De Henauw, S; Deepa, M; DeGennaro, V ; Demarest, S; Dennison, E; Deschamps, V; Dhimal, M; Dika, Z; Djalalinia, S; Donfrancesco, C; Dong, GH; Dorobantu, M; Dörr, M; Dragano, N; Drygas, W; Du, Y; Duante, CA; Duboz, P; Dushpanova, A; Dziankowska-Zaborszczyk, E; Ebrahimi, N; Eddie, R; Eftekhar, E; Efthymiou, V; Egbagbe, EE; Eghtesad, S; El-Khateeb, M; El Ati, J; Eldemire-Shearer, D; Elosua, R; Enang, O; Erasmus, RT; Erbel, R; Erem, C; Ergor, G; Eriksen, L; Eriksson, JG; Esmaeili, A; Evans, RG; Fakhradiyev, I; Fall, CH; Faramarzi, E; Farjam, M; Farzi, Y; Fattahi, MR; Fawwad, A; Felix-Redondo, FJ; Ferguson, TS; Fernández-Bergés, D; Ferrari, M; Ferreccio, C; Ferreira, HS; Ferrer, E; Feskens, EJM; Flood, D; Forsner, M; Fosse, S; Fottrell, EF; Fouad, HM; Francis, DK; Frontera, G; Furusawa, T; Gaciong, Z; Garnett, SP; Gasull, M; Gazzinelli, A; Gehring, U; Ghaderi, E; Ghamari, SH; Ghanbari, A; Ghasemi, E; Gheorghe-Fronea, OF; Ghimire, A; Gialluisi, A; Giampaoli, S; Gianfagna, F; Gill, TK; Gironella, G; Giwercman, A; Goltzman, D; Gomula, A; Gonçalves, H; Gonçalves, M; Gonzalez-Chica, DA; Gonzalez-Gross, M; González-Rivas, JP; González-Villalpando, ME; Gonzalez, AR; Gottrand, F; Grafnetter, D; Grodzicki, T; Grontved, A; Guerrero, R; Gujral, UP; Gupta, R; Gutierrez, L; Gwee, X; Haghshenas, R; Hakimi, H; Hambleton, IR; Hamzeh, B; Hanekom, WA; Hange, D; Hantunen, S; Hao, J; Kumar, RH; Harooni, J; Hashemi-Shahri, SM; Hata, J; Heidemann, C; Henrique, RD; Herrala, S; Herzig, KH; Heshmat, R; Ho, SY; Holdsworth, M; Homayounfar, R; Hopman, WM; Horimoto, ARVR; Hormiga, C; Horta, BL; Houti, L; Howitt, C; Htay, TT; Htet, AS; Htike, MMT; Huerta, JM; Huhtaniemi, IT; Huisman, M; Husseini, A; Huybrechts, I; Iacoviello, L; Iakupova, EM; Iannone, AG; Wong, NI; Ijoma, C; Irazola, VE; Ishida, T; Isiguzo, GC; Islam, SMS; Islek, D; Ittermann, T; Iwasaki, M; Jääskeläinen, T; Jacobs, JM; Jaddou, HY; Jadoul, M; Jallow, B; James, K; Jamil, KM; Janus, E; Jarvelin, MR; Jasienska, G; Jelakovic, A; Jelakovic, B; Jennings, G; Jha, AK; Jimenez, RO; Jöckel, KH; Jokelainen, JJ; Jonas, JB; Joshi, P; Josipovic, J; Joukar, F; Józwiak, J; Kafatos, A; Kajantie, EO; Kalmatayeva, Z; Karki, KB; Katibeh, M; Kauhanen, J; Kazakbaeva, GM; Kaze, FF; Ke, C; Keinänen-Kiukaanniemi, S; Kelishadi, R; Keramati, M; Kersting, M; Khader, YS; Khaledifar, A; Khalili, D; Kheiri, B; Kheradmand, M; Khosravi, A; Kiechl-Kohlendorfer, U; Kiechl, SJ; Kiechl, S; Kingston, A; Klakk, H; Klanova, J; Knoflach, M; Kolsteren, P; König, J; Korpelainen, R; Korrovits, P; Kos, J; Koskinen, S; Kowlessur, S; Koziel, S; Kriemler, S; Kristensen, PL; Kromhout, D; Kubinova, R; Kujala, UM; Kulimbet, M; Kurjata, P; Kyobutungi, C; La, QN; Labadarios, D; Lachat, C; Laid, Y; Lall, L; Lankila, T; Lanska, V; Lappas, G; Larijani, B; Latt, TS; Laurenzi, M; Lehmann, N; Lehtimäki, T; Lemogoum, D; Leung, GM; Li, YP; Lima-Costa, MF; Lin, HH; Lind, L; Lissner, L; Liu, XT; Lopez-Garcia, E; Lopez, T; Lozano, JE; Luksiene, D; Lundqvist, A; Lunet, N; Lustigová, M; Machado-Coelho, GLL; Machado-Rodrigues, AM; Macia, E; Macieira, LM; Madar, AA; Maestre, GE; Maggi, S; Magliano, DJ; Magriplis, E; Mahasampath, G; Maire, B; Makdisse, M; Malekpour, MR; Malekzadeh, F; Malekzadeh, R; Rao, KM; Malyutina, S; Maniego, L; Manios, Y; Mannix, MI; Mansour-Ghanaei, F; Manzato, E; Margozzini, P; Mariño, J; Marques, LP; Martorell, R; Mascarenhas, LP; Masinaei, M; Mathiesen, EB; Matsha, TE; Posso, AJM; McFarlane, SR; McGarvey, ST; Benchekor, SM; Mehlig, K; Mehrparvar, AH; Melgarejo, JD; Méndez, F; Menezes, AMB; Mereke, A; Meshram, II; Meto, DT; Minderico, CS; Mini, GK; Miquel, JF; Miranda, JJ; Mirjalili, MR; Modesti, PA; Moghaddam, SS; Mohamed, MK; Mohammad, K; Mohammadi, MR; Mohammadi, Z; Mohammadifard, N; Mohammadpourhodki, R; Mohan, V; Yusoff, MFM; Mohebbi, I; Moller, NC; Molnár, D; Momenan, A; Mondo, CK; Mendoza, RAM; Monterrubio-Flores, E; Moosazadeh, M; Moradpour, F; Morejon, A; Moreno, LA; Morgan, K; Morin, SN; Moslem, A; Mosquera, M; Mossakowska, M; Mostafa, A; Mostafavi, SA; Motlagh, ME; Motta, J; Msyamboza, KP; Mu, TT; Muiesan, ML; Mursu, J; Musa, KI; Mustafa, N; Muyer, MTMC; Nabipour, I; Nagel, G; Naidu, BM; Najafi, F; Námesná, J; Nangia, VB; Naseri, T; Neelapaichit, N; Nejatizadeh, A; Nenko, I; Nervi, F; Ng, TP; Nguyen, CT; Nguyen, QN; Ni, MY; Nie, P; Nieto-Martínez, RE; Ninomiya, T; Noale, M; Noboa, OA; Noto, D; Al Nsour, M; Nuhoglu, I; O'Neill, TW; Odili, AN; Oh, K; Ohtsuka, R; Omar, MA; Onat, A; Ong, SK; Onodugo, O; Ordunez, P; Ornelas, R; Ortiz, PJ; Osmond, C; Ostovar, A; Otero, JA; Ottendahl, CB; Otu, A; Owusu-Dabo, E; Palmieri, L; Pan, WH; Panda-Jonas, S; Panza, F; Paoli, M; Park, S; Parsaeian, M; Patel, ND; Pechlaner, R; Pecin, I; Pedro, JM; Peixoto, SV; Peltonen, M; Pereira, AC; dos Prazeres, TMP; Peykari, N; Phall, MC; Pham, ST; Phan, HH; Pichardo, RN; Pikhart, H; Pilav, A; Piler, P; Pitakaka, F; Piwonska, A; Pizarro, AN; Plans-Rubió, P; Plata, S; Porta, M; Poudyal, A; Pourfarzi, F; Pourshams, A; Poustchi, H; Pradeepa, R; Providencia, R; Puder, JJ; Puhakka, S; Punab, M; Qorbani, M; Quintana, HK; Bao, TQ; Rahimikazerooni, S; Raitakari, O; Ramirez-Zea, M; Ramke, J; Ramos, R; Rampal, L; Rampal, S; Reina, DAR; Rashidi, MM; Redon, J; Renner, JDP; Reuter, CP; Revilla, L; Rezaei, N; Rezaianzadeh, A; Rigo, F; Roa, RG; Robinson, L; Rodríguez-Artalejo, F; Rodriguez-Perez, MD; Rodríguez-Villamizar, LA; Rodríguez, AY; Roggenbuck, U; Rohloff, P; Romeo, EL; Rosengren, A; Rubinstein, A; Rust, P; Rutkowski, M; Sabbaghi, H; Sachdev, HS; Sadjadi, A; Safarpour, AR; Safi, S; Safiri, S; Saghi, MH; Saidi, O; Saki, N; Salaj, S; Salanave, B; Salonen, JT; Salvetti, M; Sánchez-Abanto, J; Santos, DA; Santos, LC; Santos, MP; Santos, TR; Saramies, JL; Sardinha, LB; Sarrafzadegan, N; Saum, KU; Sbaraini, M; Scazufca, M; Schaan, BD; Scheidt-Nave, C; 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Tuliakova, AM; Tulloch-Reid, MK; Tuomainen, TP; Tzala, E; Tzourio, C; Ueda, P; Ugel, E; Ukoli, FAM; Ulmer, H; Uusitalo, HMT; Valdivia, G; Van den Born, BJ; Van der Heyden, J; Minh, HV; van Rossem, L; Van Schoor, NM; van Valkengoed, IGM; van Zutphen, EM; Vanderschueren, D; Vanuzzo, D; Vasan, SK; Vega, T; Velasquez-Melendez, G; Verstraeten, R; Viet, L; Villalpando, S; Vioque, J; Virtanen, JK; Viswanathan, B; Voutilainen, A; Bebakar, WMW; Mohamud, WNW; Wang, CJ; Wang, NL; Wang, Q; Wang, YX; Wang, YW; Wannamethee, SG; Webster-Kerr, K; Wedderkopp, N; Wei, WB; Westbury, LD; Whincup, PH; Widhalm, K; Widyahening, IS; Wiecek, A; Wilks, RJ; Willeit, J; Willeit, P; Wilsgaard, T; Wojtyniak, B; Wong, A; Wong, EB; Woodward, M; Wu, FC; Xu, HQ; Xu, L; Yaacob, NA; Yan, L; Yan, WL; Yoosefi, M; Yoshihara, A; Younger-Coleman, NO; Yu, YL; Yu, YJ; Yusoff, AF; Zainuddin, AA; Zamani, F; Zambon, S; Zampelas, A; Zaw, KK; Vrkic, TZ; Zeng, Y; Zhang, ZY; Zholdin, B; Zimmet, P; Zitt, E; Zoghlami, N; Cisneros, JZ; Ezzati, M

    NATURE MEDICINE   29 ( 11 )   2885 - 2901   2023.11   ISSN:1078-8956 eISSN:1546-170X

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    Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening, had elevated FPG, HbA1c or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardized proportion of diabetes that was previously undiagnosed and detected in survey screening ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the age-standardized proportion who had elevated levels of both FPG and HbA1c was 29–39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c was more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global shortfall in diabetes diagnosis and surveillance.

    DOI: 10.1038/s41591-023-02610-2

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  • 地域在住の日本人高齢者において性別と年齢は歩行速度と軽度認知障害の関連に影響を及ぼす Japan Prospective Studies Collaboration for Ageing and Dementia(JPSC-AD)(Gender and age influence the association between gait speed and mild cognitive impairment in community-dwelling Japanese older adults: from the Japan Prospective Studies Collaboration for Ageing and Dementia(JPSC-AD))

    Bun Shogyoku, Suzuki Kouta, Niimura Hidehito, Shikimoto Ryo, Kida Hisashi, Shibata Mao, Honda Takanori, Ohara Tomoyuki, Hata Jun, Nakaji Shigeyuki, Maeda Tetsuya, Ono Kenjiro, Nakashima Kenji, Iga Jun-ichi, Takebayashi Minoru, Ninomiya Toshiharu, Mimura Masaru

    Psychogeriatrics   23 ( 6 )   918 - 929   2023.11   ISSN:1346-3500

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    日本人高齢者における軽度認知障害(MCI)と歩行速度の関連について検討した。2016~2018年にJPSC-ADに参加した65歳以上の日本人8233人(男性3540人、女性4693人、平均72.8±6.0歳)を対象とした。性別及び年齢グループにより層別化した後、参加者の歩行速度を5グループに分けた。その結果、歩行速度の低下はMCIのオッズ上昇と関連し、性別及び年齢により変化していた。また、歩行速度はMCIのスクリーニングツールとして有用であることが示された。

  • Inadequate care and excessive overprotection during childhood are associated with the presence of diabetes mellitus in adulthood in a general Japanese population: a cross-sectional analysis from the Hisayama Study. International journal

    Mao Shibata, Masako Hosoi, Kozo Anno, Naoki Hirabayashi, Yoichiro Hirakawa, Hiroshi Kawata, Rie Iwaki, Ryoko Sawamoto, Nobuyuki Sudo, Toshiharu Ninomiya

    BMC endocrine disorders   23 ( 1 )   222 - 222   2023.10   eISSN:1472-6823

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    OBJECTIVE: To investigate associations between parenting styles during childhood and diabetes in adulthood in a Japanese community. METHODS: In 2011, 710 community-dwelling Japanese residents aged ≥ 40 years were assessed for the presence of diabetes and for their perceptions of the parenting style of their parents, as measured using the "care" and "overprotection" scales of the Parental Bonding Instrument. Care and overprotection scores for each parent were dichotomized by age-specific median values. Diabetes mellitus was defined as a fasting plasma glucose level of ≥ 7.0 mmol/L, a 2-h post-loaded glucose level of ≥ 11.1 mmol/L, HbA1c ≥ 6.5%, and/or the current use of insulin or oral glucose-lowering agents. The odds ratios (ORs) for prevalent diabetes were calculated using a logistic regression model. RESULTS: The prevalence of diabetes was 14.9%. Subjects with a high paternal overprotection score had a significantly greater likelihood of prevalent diabetes than those with a low paternal overprotection score after adjusting for confounders (OR 1.71, 95% confidence interval [CI] 1.06-2.77), while there was no significant association between paternal care and diabetes. Additionally, the multivariable-adjusted ORs for the presence of diabetes were significantly higher in subjects with a low maternal care score (OR 1.61, 95%CI 1.00-2.60) or in subjects with a high maternal overprotection score (OR 1.73, 95%CI 1.08-2.80). Moreover, the subjects with a low care score and high overprotection score for both their father and mother had a significantly higher multivariable-adjusted OR of diabetes than those with a high care score and low overprotection score for both parents (OR 2,12, 95%CI 1.14-3.95). CONCLUSIONS: This study suggests that inadequate care and excessive overprotection during childhood may contribute to the development of diabetes in adulthood.

    DOI: 10.1186/s12902-023-01474-4

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  • Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality. International journal

    Christina Magnussen, Francisco M Ojeda, Darryl P Leong, Jesus Alegre-Diaz, Philippe Amouyel, Larissa Aviles-Santa, Dirk De Bacquer, Christie M Ballantyne, Antonio Bernabé-Ortiz, Martin Bobak, Hermann Brenner, Rodrigo M Carrillo-Larco, James de Lemos, Annette Dobson, Marcus Dörr, Chiara Donfrancesco, Wojciech Drygas, Robin P Dullaart, Gunnar Engström, Marco M Ferrario, Jean Ferrières, Giovanni de Gaetano, Uri Goldbourt, Clicerio Gonzalez, Guido Grassi, Allison M Hodge, Kristian Hveem, Licia Iacoviello, M Kamran Ikram, Vilma Irazola, Modou Jobe, Pekka Jousilahti, Pontiano Kaleebu, Maryam Kavousi, Frank Kee, Davood Khalili, Wolfgang Koenig, Anna Kontsevaya, Kari Kuulasmaa, Karl J Lackner, David M Leistner, Lars Lind, Allan Linneberg, Thiess Lorenz, Magnus Nakrem Lyngbakken, Reza Malekzadeh, Sofia Malyutina, Ellisiv B Mathiesen, Olle Melander, Andres Metspalu, J Jaime Miranda, Marie Moitry, Joseph Mugisha, Mahdi Nalini, Vijay Nambi, Toshiharu Ninomiya, Karen Oppermann, Eleonora d'Orsi, Andrzej Pająk, Luigi Palmieri, Demosthenes Panagiotakos, Arokiasamy Perianayagam, Annette Peters, Hossein Poustchi, Andrew M Prentice, Eva Prescott, Ulf Risérus, Veikko Salomaa, Susana Sans, Satoko Sakata, Ben Schöttker, Aletta E Schutte, Sadaf G Sepanlou, Sanjib Kumar Sharma, Jonathan E Shaw, Leon A Simons, Stefan Söderberg, Abdonas Tamosiunas, Barbara Thorand, Hugh Tunstall-Pedoe, Raphael Twerenbold, Diego Vanuzzo, Giovanni Veronesi, Julia Waibel, S Goya Wannamethee, Masafumi Watanabe, Philipp S Wild, Yao Yao, Yi Zeng, Andreas Ziegler, Stefan Blankenberg

    The New England journal of medicine   389 ( 14 )   1273 - 1285   2023.10   ISSN:0028-4793 eISSN:1533-4406

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    BACKGROUND: Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking. METHODS: We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality. RESULTS: Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6). CONCLUSIONS: Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825.).

    DOI: 10.1056/NEJMoa2206916

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  • Global impact of modifiable risk factors on cardiovascular disease and mortality. Invited Reviewed International journal

    Global Cardiovascular Risk Consortium( Sakata S, Ninomiya T)

    N Engl J Med   389   1273 - 1285   2023.10

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  • Inadequate care and excessive overprotection during childhood are associated with the presence of diabetes mellitus in adulthood in a general Japanese population: a cross-sectional analysis from the Hisayama Study. Invited Reviewed International journal

    Shibata M, Hosoi M, Anno K, Hirabayashi N, Hirakawa Y, Kawata H, Iwaki R, Sawamoto R, Sudo N, Ninomiya T

    BMC Endocr Disord   23   222   2023.10

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  • Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation

    Kaptoge, S; Sun, L; Walker, M; Spackman, S; Pennells, L; Seshasai, SRK; Bolton, T; Ataklte, F; Willeit, P; Bell, S; Burgess, S; Altay, S; Assmann, G; Ben-Shlomo, Y; Best, LG; Björkelund, C; Blazer, DG; Brenner, H; Brunner, EJ; Dagenais, GR; Cooper, JA; Cooper, C; Crespo, CJ; Cushman, M; D'Agostino, RB ; Daimon, M; Daniels, LB; Dankner, R; Davidson, KW; de Jongh, RT; Donfrancesco, C; Ducimetiere, P; Elders, PJM; Engström, G; Ford, I; Gallacher, J; Bakker, SJL; Goldbourt, U; de la Cámara, AG; Grimsgaard, S; Gudnason, V; Hansson, PO; Imano, H; Jukema, JW; Kabrhel, C; Kauhanen, J; Kavousi, M; Kiechl, S; Knuiman, MW; Kromhout, D; Krumholz, HM; Kuller, LH; Laatikainen, T; Lawlor, DA; Meyer, HE; Mukamal, K; Nietert, PJ; Ninomiya, T; Nitsch, D; Nordestgaard, BG; Palmieri, L; Price, JF; Ridker, PM; Sun, Q; Rosengren, A; Roussel, R; Sakurai, M; Salomaa, V; Schöttker, B; Shaw, JE; Strandberg, TE; Sundström, J; Tolonen, H; Tverdal, A; Verschuren, WMM; Völzke, H; Wagenknecht, L; Wallace, RB; Wannamethee, SG; Wareham, NJ; Wassertheil-Smoller, S; Yamagishi, K; Yeap, BB; Harrison, S; Thompson, SG; Inouye, M; Griffin, S; Butterworth, AS; Wood, AM; Sattar, N; Danesh, J; Di Angelantonio, E

    LANCET DIABETES & ENDOCRINOLOGY   11 ( 10 )   731 - 742   2023.10   ISSN:2213-8587 eISSN:2213-8595

  • Association Between Frequency of Social Contact and Brain Atrophy in Community-Dwelling Older People Without Dementia: The JPSC-AD Study. International journal

    Naoki Hirabayashi, Takanori Honda, Jun Hata, Yoshihiko Furuta, Mao Shibata, Tomoyuki Ohara, Yasuko Tatewaki, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya

    Neurology   101 ( 11 )   E1108 - E1117   2023.9   ISSN:0028-3878 eISSN:1526-632X

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    BACKGROUND AND OBJECTIVES: Epidemiological evidence has shown that social isolation, a low frequency of social contact with others, is associated with the risk of dementia and late-life depressive symptoms. Therefore, we hypothesized that low frequency of social contact may be involved in brain atrophy, and depressive symptoms may play some role in this relationship. We aimed to evaluate the association between low frequency of social contact and the volumes of various brain regions and to assess the extent to which depressive symptoms mediate these relationships from a large population-based multisite cohort study. METHODS: Dementia-free community-dwelling Japanese aged ≥65 years underwent brain MRI scans and a comprehensive health examination. Frequency of contact with non-cohabiting relatives and friends was determined by asking a single question with four categories: everyday, several times a week, several times a month, and seldom. Total and regional brain volumes, intracranial volume (ICV) and white matter lesions volume were estimated using FreeSurfer software. The associations between frequency of social contact and brain volumes per ICV were examined using analyses of covariance. Mediation analyses were conducted to calculate the proportion of the associations explained by depressive symptoms. RESULTS: We included 8,896 participants. The multivariable-adjusted mean of the total brain volume in the group with the lowest frequency of social contact was significantly lower compared to that in the group with the highest frequency (67.3% vs 67.8%), with a significant increasing trend across the groups (p value for trend <0.001). The white matter lesions volume increased significantly with lower frequency of social contact (0.30% in the lowest frequency vs 0.26% in the highest frequency group, p value for trend <0.001). Lower frequency of social contact was associated with smaller volumes in the temporal lobe, occipital lobe, cingulum, hippocampus, and amygdala (all q value of FDR correction <0.05). The relationships appeared to be partly mediated by depressive symptoms, which accounted for 15% to 29% of the observed associations. DISCUSSION: Lower frequency of social contact was associated with decreased total and cognitive function-related regional brain volumes. In addition, depressive symptoms partially explained the association in community-dwelling older people without dementia in Japan.

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  • Association between frequency of social contact and brain atrophy in community-dwelling older people without dementia: the JPSC-AD Study. Invited Reviewed International journal

    Hirabayashi N, Honda T, Hata J, Furuta Y, Shibata M, Ohara T, Tatewaki Y, Taki Y, Nakaji S, Maeda T, Ono K, Mimura M, Nakashima K, Iga JI, Takebayashi M, Ninomiya T; as the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) Study

    Neurology 101: e1108-e1117, 2023   101   e1108 - e1117   2023.9

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  • Reorganization of Corticospinal Projections after Prominent Recovery of Finger Dexterity from Partial Spinal Cord Injury in Macaque Monkeys

    Sawada, M; Yoshino-Saito, K; Ninomiya, T; Oishi, T; Yamashita, T; Onoe, H; Takada, M; Nishimura, Y; Isa, T

    ENEURO   10 ( 8 )   2023.8   eISSN:2373-2822

  • Skin carotenoid levels and metabolic syndrome in a general Japanese population: the Hisayama Study

    Kimura, Y; Hata, J; Honda, T; Shibata, M; Sakata, S; Furuta, Y; Ninomiya, T

    ANNALS OF NUTRITION AND METABOLISM   79   903 - 903   2023.8   ISSN:0250-6807 eISSN:1421-9697

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  • Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation. International journal

    Frank Qian, Nathan Tintle, Paul N Jensen, Rozenn N Lemaitre, Fumiaki Imamura, Tobias Rudholm Feldreich, Sarah Oppeneer Nomura, Weihua Guan, Federica Laguzzi, Eunjung Kim, Jyrki K Virtanen, Marinka Steur, Christian S Bork, Yoichiro Hirakawa, Michelle L O'Donoghue, Aleix Sala-Vila, Andres V Ardisson Korat, Qi Sun, Eric B Rimm, Bruce M Psaty, Susan R Heckbert, Nita G Forouhi, Nicholas J Wareham, Matti Marklund, Ulf Risérus, Lars Lind, Johan Ärnlöv, Parveen Garg, Michael Y Tsai, James Pankow, Jeffrey R Misialek, Bruna Gigante, Karin Leander, Julie A Pester, Christine M Albert, Maryam Kavousi, Arfan Ikram, Trudy Voortman, Erik B Schmidt, Toshiharu Ninomiya, David A Morrow, Antoni Bayés-Genís, James H O'Keefe, Kwok Leung Ong, Jason H Y Wu, Dariush Mozaffarian, William S Harris, David S Siscovick

    Journal of the American College of Cardiology   82 ( 4 )   336 - 349   2023.7   ISSN:0735-1097 eISSN:1558-3597

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    BACKGROUND: The relationship between omega-3 fatty acids and atrial fibrillation (AF) remains controversial. OBJECTIVES: This study aimed to determine the prospective associations of blood or adipose tissue levels of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with incident AF. METHODS: We used participant-level data from a global consortium of 17 prospective cohort studies, each with baseline data on blood or adipose tissue omega-3 fatty acid levels and AF outcomes. Each participating study conducted a de novo analyses using a prespecified analytical plan with harmonized definitions for exposures, outcome, covariates, and subgroups. Associations were pooled using inverse-variance weighted meta-analysis. RESULTS: Among 54,799 participants from 17 cohorts, 7,720 incident cases of AF were ascertained after a median 13.3 years of follow-up. In multivariable analysis, EPA levels were not associated with incident AF, HR per interquintile range (ie, the difference between the 90th and 10th percentiles) was 1.00 (95% CI: 0.95-1.05). HRs for higher levels of DPA, DHA, and EPA+DHA, were 0.89 (95% CI: 0.83-0.95), 0.90 (95% CI: 0.85-0.96), and 0.93 (95% CI: 0.87-0.99), respectively. CONCLUSIONS: In vivo levels of omega-3 fatty acids including EPA, DPA, DHA, and EPA+DHA were not associated with increased risk of incident AF. Our data suggest the safety of habitual dietary intakes of omega-3 fatty acids with respect to AF risk. Coupled with the known benefits of these fatty acids in the prevention of adverse coronary events, our study suggests that current dietary guidelines recommending fish/omega-3 fatty acid consumption can be maintained.

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  • Epidemiology of Stroke in a General Japanese Population: The Hisayama Study

    Hata Jun, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   30 ( 7 )   710 - 719   2023.7   ISSN:13403478 eISSN:18803873

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    <p>The Hisayama Study is an ongoing epidemiological study of stroke, coronary artery disease (CAD), and other noncommunicable diseases in a general Japanese population established in 1961. According to the longitudinal data from the Hisayama Study, average levels of systolic blood pressure among hypertensive individuals have decreased with time since 1961. In contrast, the prevalence of metabolic risk factors such as obesity, hypercholesterolemia, and glucose intolerance has increased with time. The incidence rates of ischemic stroke in this population have declined significantly as a result of improvement in hypertension management, but the proportion of atherothrombotic brain infarction (ATBI) and embolic stroke among the total ischemic stroke cases have increased probably due to the increased prevalence of metabolic risk factors and the increased number of patients with atrial fibrillation (AF) with super-aging population. Therefore, a strategy to reduce the risks of ATBI and embolic stroke by comprehensive management of their risk factors is necessary.</p><p>In this review, we first show the secular trends in the incidence of stroke and the prevalence of its risk factors using the data from the Hisayama Study. Then, the studies for the association of traditional risk factors with stroke development in the Hisayama Study are introduced. Finally, we developed risk prediction models to estimate the absolute risk of atherosclerotic cardiovascular disease (ASCVD; including ATBI and CAD) and AF, that may be used for the stratification of future risk of ATBI and AF-related stroke in clinical practice or health examination.</p>

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  • Omega-3 fatty acid biomarkers and incident atrial fibrillation. Invited Reviewed International journal

    Qian F, Tintle N, Jensen PN, Lemaitre RN, Imamura F, Feldreich TR, Nomura SO, Guan W, Laguzzi F, Kim E, Virtanen JK, Steur M, Bork CS, Hirakawa Y, O'Donoghue ML, Sala-Vila A, Ardisson Korat AV, Sun Q, Rimm EB, Psaty BM, Heckbert SR, Forouhi NG, Wareham NJ

    J Am Coll Cardiol   82   336 - 349   2023.7

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  • High-Resolution Detection of Translocation of Oral Bacteria to the Gut

    Kageyama, S; Sakata, S; Ma, J; Asakawa, M; Takeshita, T; Furuta, M; Ninomiya, T; Yamashita, Y

    JOURNAL OF DENTAL RESEARCH   102 ( 7 )   752 - 758   2023.7   ISSN:0022-0345 eISSN:1544-0591

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    Ectopic enrichment of oral microbes in the gut is a notable alteration in gut microbial balance. These microbes are likely delivered from the oral cavity with saliva and food; however, evidence of oral–gut microbial transmission is insufficient and needs further investigation. In this observational study, we examined 144 pairs of saliva and stool samples collected from community-dwelling adults to verify the oral–gut microbial link and identify the relevant influencing factors on the increased abundance of oral microbes within the gut. The bacterial composition of each sample was determined using PacBio single-molecule long-read sequencing of the full-length 16S ribosomal RNA gene and amplicon sequence variant (ASV) analysis. Although the bacterial compositions of salivary and gut microbiota were distinctly different, at least 1 ASV was shared between salivary and gut microbiota in 72.9% of subjects. Shared ASVs accounted for 0.0% to 63.1% (median 0.14%) of the gut microbiota in each subject and frequently included abundant Streptococcus salivarius and Streptococcus parasanguinis. Their total relative abundance in the gut was significantly higher in older subjects or those with dental plaque accumulation. The gut microbiota with ≥5% of shared ASVs displayed a higher abundance of Streptococcus, Lactobacillus, and Klebsiella and a lower abundance of Faecalibacterium, Blautia, Megamonas, and Parabacteroides. Our study presents evidence for the translocation of oral bacteria to the gut in community-dwelling adults and suggests that aging and dental plaque accumulation contribute to an increased abundance of oral microbes in the gut, which might be relevant to the compositional shift in the gut commensals.

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  • Serum Mac-2 Binding Protein Glycosylation Isomer Concentrations Are Associated With Incidence of Type 2 Diabetes. International journal

    Mayu Higashioka, Yoichiro Hirakawa, Jun Hata, Takanori Honda, Satoko Sakata, Mao Shibata, Takanari Kitazono, Haruhiko Osawa, Toshiharu Ninomiya

    The Journal of clinical endocrinology and metabolism   108 ( 7 )   E425 - E433   2023.6   ISSN:0021-972X eISSN:1945-7197

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    CONTEXT: Serum Mac-2 binding protein glycosylation isomer (M2BPGi) concentrations are known to be an indicator of chronic liver injury and fibrosis. OBJECTIVE: This study aimed to investigate the association between serum M2BPGi concentrations and the development of type 2 diabetes in a Japanese community. METHODS: A total of 2143 community-dwelling Japanese individuals aged 40-79 years without diabetes at baseline were followed up for 7 years. Serum M2BPGi concentrations were divided into quintiles: Q1, ≤0.37 cutoff index (COI); Q2, 0.38-0.49 COI; Q3, 0.50-0.62 COI; Q4, 0.62-0.80 COI; and Q5, ≥0.81 COI. Cox proportional hazards models were used to estimate hazard ratios and 95% CIs for the development of type 2 diabetes. RESULTS: During the follow-up period, 219 individuals developed type 2 diabetes. The age- and sex-adjusted cumulative incidence of type 2 diabetes significantly increased with elevating serum M2BPGi levels (P for trend < .01). This association remained significant after adjustment for potential confounders (P for trend = .04). This significant association attenuated to a nonsignificant level after additionally adjusting for serum high-sensitivity C-reactive protein or homeostasis model assessment of insulin resistance. CONCLUSION: The present study demonstrated that higher serum M2BPGi concentrations were significantly associated with higher risk of diabetes in a Japanese community. Moreover, inflammation and insulin resistance were suggested to contribute to the excess risk of diabetes in individuals with higher serum M2BPGi levels. These findings shed light on the importance of inflammation and insulin resistance when considering the pathogenesis of diabetes.

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  • Changes in the Eicosapentaenoic Acid to Arachidonic Acid Ratio in Serum over 10 Years in a Japanese Community: The Hisayama Study

    Honda Takanori, Chen Sanmei, Hata Jun, Shibata Mao, Furuta Yoshihiko, Oishi Emi, Sakata Satoko, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   30 ( 6 )   589 - 600   2023.6   ISSN:13403478 eISSN:18803873

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    <p> <b>Aim:</b> Circulating omega-3 and omega-6 polyunsaturated fatty acids may to contribute to cardiovascular health at the population level. Over a decade, we investigated changes in the serum eicosapentaenoic acid (EPA) to arachidonic acid (AA) ratio, and in serum concentrations of the individual fatty acids, in a Japanese community.</p><p> <b>Methods:</b> Community surveys took place in 2002–2003 and 2012–2013 in a rural area of Japan. The community surveys included 3,194 and 3,220 community dwellers aged ≥ 40 years who did not take EPA medication in 2002–2003 and 2012–2013, respectively. Fatty acid fractionations in serum were measured using a gas chromatography method. Changes in the serum EPA/AA ratio over time were examined using linear mixed models.</p><p><b>Results:</b> Overall, the average serum EPA/AA ratio decreased over the 10 years. A decreasing trend in the serum EPA/AA ratio occurred in all age groups except participants aged ≥ 80 years, with larger decreases in the younger age groups. A similar decline in serum EPA/AA ratio occurred in participants with and those without lipid-lowering therapy. Serum EPA concentrations were slightly increased in the whole population but remained stable or even decreased in participants aged 40–69. In contrast, the average serum AA concentrations increased in all age groups.</p><p><b>Conclusion:</b> In a Japanese community, the serum EPA/AA ratio decreased over 10 years at the population level, especially in middle-aged participants.</p>

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  • Association between choroidal thickness and myopic maculopathy in a Japanese population: the Hisayama Study. Invited Reviewed International journal

    Ueda E, Yasuda M, Fujiwara K, Hashimoto S, Honda T, Nakamura S, Hata J, Ninomiya T, Sonoda KH

    Ophthalmol Sci   3   100350   2023.6

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  • Association of white matter lesions and brain atrophy with the development of dementia in a community: the Hisayama Study. Invited Reviewed International journal

    Nakazawa T, Ohara T, Hirabayashi N, Furuta Y, Hata J, Shibata M, Honda T, Kitazono T, Nakao T, Ninomiya T

    Psychiatry Clin Neurosci   77   330 - 337   2023.6

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  • Changes in the eicosapentaenoic acid to arachidonic acid ratio in serum over 10 years in a Japanese community: the Hisayama Study. Invited Reviewed International journal

    Honda T, Chen S, Hata J, Shibata M, Furuta Y, Oishi E, Sakata S, Kitazono T, Ninomiya T

    J Atheroscler Thromb   30   589 - 600   2023.6

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  • Serum Mac-2 binding protein glycosylation isomer concentrations are associated with incidence of type 2 diabetes. Invited Reviewed International journal

    Higashioka M, Hirakawa Y, Hata J, Honda T, Sakata S, Shibata M, Kitazono T, Osawa H, Ninomiya T

    J Clin Endocrinol Metab   108   e425 - e433   2023.6

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  • Association of white matter lesions and brain atrophy with the development of dementia in a community: the Hisayama Study. International journal

    Taro Nakazawa, Tomoyuki Ohara, Naoki Hirabayashi, Yoshihiko Furuta, Jun Hata, Mao Shibata, Takanori Honda, Takanari Kitazono, Tomohiro Nakao, Toshiharu Ninomiya

    Psychiatry and clinical neurosciences   77 ( 6 )   330 - 337   2023.6   ISSN:1323-1316 eISSN:1440-1819

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    AIM: To investigate the association of white matter lesions volume (WMLV) levels with dementia risk and the association between dementia risk and the combined measures of WMLV and either total brain atrophy or dementia-related gray matter atrophy in a general older population. METHODS: One thousand one hundred fifty-eight Japanese dementia-free community-residents aged ≥65 years who underwent brain magnetic resonance imaging were followed for 5.0 years. WMLV were segmented using the Lesion Segmentation Toolbox. Total brain volume (TBV) and regional gray matter volume were estimated by voxel-based morphometry. The WMLV-to-intracranial brain volume ratio (WMLV/ICV) was calculated, and its association with dementia risk was estimated using Cox proportional hazard models. Total brain atrophy, defined as the TBV-to-ICV ratio (TBV/ICV), and dementia-related regional brain atrophy defined based on our previous report were calculated. The association between dementia risk and the combined measures of WMLV/ICV and either total brain atrophy or the number of atrophied regions was also tested. RESULTS: During the follow-up, 113 participants developed dementia. The risks of dementia increased significantly with higher WMLV/ICV levels. In addition, dementia risk increased additively both in participants with higher WMLV/ICV levels and lower TBV/ICV levels and in those with higher WMLV/ICV levels and a higher number of dementia-related brain regional atrophy. CONCLUSION: The risk of dementia increased significantly with higher WMLV/ICV levels. An additive increment in dementia risk was observed with higher WMLV/ICV levels and lower TBV/ICV levels or a higher number of dementia-related brain regional atrophy, suggesting the importance of prevention or control of cardiovascular risk factors.

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  • 地域における白質病変及び脳萎縮と認知症の発症の関連 久山町研究(Association of white matter lesions and brain atrophy with the development of dementia in a community: the Hisayama Study)

    Nakazawa Taro, Ohara Tomoyuki, Hirabayashi Naoki, Furuta Yoshihiko, Hata Jun, Shibata Mao, Honda Takanori, Kitazono Takanari, Nakao Tomohiro, Ninomiya Toshiharu

    Psychiatry and Clinical Neurosciences   77 ( 5-6 )   330 - 337   2023.6   ISSN:1323-1316

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    高齢者集団における白質病変容積(WMLV)及び脳萎縮と認知症リスクの関係について検討した。福岡県久山町の認知症がない65歳以上の住民のうち、脳MRIを実施した1158人(男性512人、女性646人、平均73.6±6.2歳)を対象とした。WMLVをLesion Segmentation Toolboxを用いてセグメント化し、全脳容積(TBV)と局所灰白質容積をvoxel-based morphometryを用いて推定した。頭蓋内脳容積(ICV)に対するWMLVの比(WMLV/ICV)を計算し、WMLV/ICVと認知症リスクの関連をCox比例ハザードモデルにより推定した。ICVに対するTBVの比(TBV/ICV)で定義された全脳萎縮と、著者等の過去の報告で定義された認知症関連の脳局所萎縮を算出した。5年間の経過観察期間中に113人が認知症を発症した。認知症リスクはWMLV/ICVとともに有意に増加した。WMLV/ICVが大きくTBV/ICVが小さい住民と、WMLV/ICVが大きく認知症関連の脳局所萎縮の数が多い住民では認知症リスクが相加的に増加することが観察された。

  • 日本の地域における10年間の血清エイコサペンタエン酸/アラキドン酸比の変化 久山町研究(Changes in the Eicosapentaenoic Acid to Arachidonic Acid Ratio in Serum over 10 Years in a Japanese Community: The Hisayama Study)

    Honda Takanori, Chen Sanmei, Hata Jun, Shibata Mao, Furuta Yoshihiko, Oishi Emi, Sakata Satoko, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   30 ( 6 )   589 - 600   2023.6   ISSN:1340-3478

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    日本の集団ベース研究である久山町研究のデータを用いて、集団レベルでの血清エイコサペンタエン酸(EPA)/アラキドン酸(AA)比、血清EPA濃度、血清AA濃度の10年間の変化を評価した。2002~2003年と2012~2013年に久山町研究に参加した40歳以上でEPA薬を服用していない地域住民(2002~2003年は3194名、2012~2013年は3220名)のデータを解析した。血清EPA/AA比は10年間で低下し、2002年と2012年の幾何平均値はそれぞれ0.40、0.32であった。血清EPA濃度は軽度に上昇し、2002年と2012年の幾何平均値はそれぞれ59.0μg/mL、65.1μg/mLであった。血清AA濃度は大きく上昇し、2002年と2012年の幾何平均値はそれぞれ147.6μg/mL、199.9μg/mLであった。年齢群別の解析では、血清EPA/AA比は80歳以上を除いて有意に低下し、若年群ほど低下が大きかった。血清EPA濃度は50~59歳で有意に低下し、70歳以上で有意に上昇した。血清AA濃度はすべての年齢群で有意に上昇した。

  • Family dysfunction is associated with chronic pain in a community-dwelling Japanese population: the Hisayama Study. Invited Reviewed International journal

    Saito T, Shibata M, Hirabayashi N, Honda T, Morisaki Y, Anno K, Sudo N, Hosoi M, Ninomiya T

    Eur J Pain   27   518 - 529   2023.4

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  • Family dysfunction is associated with chronic pain in a community‐dwelling Japanese population: The Hisayama study International journal

    Takafumi Saito, Mao Shibata, Naoki Hirabayashi, Takanori Honda, Yukiko Morisaki, Kozo Anno, Nobuyuki Sudo, Masako Hosoi, Toshiharu Ninomiya

    European Journal of Pain   27 ( 4 )   518 - 529   2023.4   ISSN:1090-3801 eISSN:1532-2149

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    BACKGROUND: Poor family functioning has been reported to be associated with the severity of chronic pain in outpatients, but the association has not been fully addressed in general populations. The present study aimed to examine the association between family dysfunction levels and the presence of chronic pain in a community-dwelling Japanese population. METHODS: A total of 2598 participants aged ≥40 years were classified as having healthy, borderline or unhealthy family functioning. Chronic pain was defined as subjective pain for three months or longer, and further classified by pain intensity, the number of chronic pain sites, pain duration and the extent of pain spread. A logistic regression model was used to compute the odds ratios (ORs) for chronic pain outcomes. RESULTS: The prevalence of chronic pain was 49%. The age- and sex-adjusted prevalence of total and severe chronic pain were increased significantly with increasing family dysfunction levels (all p for trend <0.01). After adjusting for sociodemographic, physical, social and family structure factors, the ORs (95% confidence intervals [CI]) for having chronic pain among borderline and unhealthy groups were 1.20 (1.01-1.44) and 1.43 (1.15-1.79), respectively, as compared with a healthy family function group. The association was stronger among people who were employed and those who were living with their children. In addition, the ORs for severe chronic pain increased significantly with increasing levels of family dysfunction. CONCLUSIONS: The family dysfunction level was positively associated with the presence as well as the severity of chronic pain in a community-dwelling population. SIGNIFICANCE: A biopsychosocial burden due to family relationships could worsen the clinical presentation of pain. Social support or family therapy for dysfunctional families would be a potential initiative for the prevention or management of chronic pain.

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  • Diminishing benefits of urban living for children and adolescents' growth and development

    Mishra, A; Zhou, B; Rodriguez-Martinez, A; Bixby, H; Singleton, RK; Carrillo-Larco, RM; Sheffer, KE; Paciorek, CJ; Bennett, JE; Lhoste, V; Iurilli, MLC; Di Cesare, M; Bentham, J; Phelps, NH; Sophiea, MK; Stevens, GA; Danaei, G; Cowan, MJ; Savin, S; Riley, LM; Gregg, EW; Aekplakorn, W; Ahmad, NA; Baker, JL; Chirita-Emandi, A; Farzadfar, F; Fink, G; Heinen, M; Ikeda, N; Kengne, AP; Khang, YH; Laatikainen, T; Laxmaiah, A; Ma, J; Monroy-Valle, M; Mridha, MK; Padez, CP; Reynolds, A; Soric, M; Starc, G; Wirth, JP; Abarca-Gómez, L; Abdeen, ZA; Abdrakhmanova, S; Ghaffar, SA; Rahim, HFA; Abdurrahmonova, Z; Abu-Rmeileh, NM; Garba, JA; Acosta-Cazares, B; Adam, I; Adamczyk, M; Adams, RJ; Adu-Afarwuah, S; Afsana, K; Afzal, S; Agbor, VN; Agdeppa, IA; Aghazadeh-Attari, J; Aguenaou, H; Aguilar-Salinas, CA; Agyemang, C; Ahmad, MH; Ahmadi, A; Ahmadi, N; Ahmadi, N; Ahmed, I; Ahmed, SH; Ahrens, W; Aitmurzaeva, G; Ajlouni, K; Al-Hazzaa, HM; Al-Lahou, B; Al-Raddadi, R; Al Hourani, HM; Al Qaoud, NM; Alarouj, M; AlBuhairan, F; AlDhukair, S; Aldwairji, MA; Alexius, S; Ali, MM; Alkandari, A; Alkerwi, A; Alkhatib, BM; Allin, K; Alvarez-Pedrerol, M; Aly, E; Amarapurkar, DN; Etxezarreta, PA; Amoah, J; Amougou, N; Amouyel, P; Andersen, LB; Anderssen, SA; Androutsos, O; Ängquist, L; Anjana, RM; Ansari-Moghaddam, A; Anufrieva, E; Aounallah-Skhiri, H; Araújo, J; Ariansen, I; Aris, T; Arku, RE; Arlappa, N; Aryal, KK; Aseffa, N; Aspelund, T; Assah, FK; Assembekov, B; Assunçao, MCF; Aung, MS; Auvinen, J; Avdicová, M; Avi, S; Azevedo, A; Azimi-Nezhad, M; Azizi, F; Azmin, M; Babu, BV; Jorgensen, MB; Baharudin, A; Bahijri, S; Bakacs, M; Balakrishna, N; Balanova, Y; Bamoshmoosh, M; Banach, M; Banegas, JR; Baran, J; Baran, R; Barbagallo, CM; Barbosa, V; Barceló, A; Baretic, M; Barkat, A; Barnoya, J; Barrera, L; Barreto, M; Barros, AJD; Barros, MVG; Bartosiewicz, A; Basit, A; Bastos, JLD; Bata, I; Batieha, AM; Batista, AP; Batista, RL; Battakova, Z; Baur, LA; Bayauli, PM; Beaglehole, R; Bel-Serrat, S; Belavendra, A; Ben Romdhane, H; Benedics, J; Benet, M; Rolandi, GEB; Bere, E; Bergh, IH; Berhane, Y; Berkinbayev, S; Bernabe-Ortiz, A; Bernotiene, G; Carrasola, XB; Bettiol, H; Beutel, ME; Beybey, AF; Bezerra, J; Bhagyalaxmi, A; Bharadwaj, S; Bhargava, SK; Bi, HS; Bi, YF; Bia, D; Biasch, K; Lele, ECB; Bikbov, MM; Bista, B; Bjelica, DJ; Bjerregaard, AA; Bjerregaard, P; Bjertness, E; Bjertness, MB; Björkelund, C; Bloch, KV; Blokstra, A; Magnazu, MB; Bo, S; Bobak, M; Boddy, LM; Boehm, BO; Boer, JMA; Boggia, JG; Bogova, E; Boissonnet, CP; Bojesen, SE; Bonaccio, M; Bongard, V; Bonilla-Vargas, A; Bopp, M; Borghs, H; Bovet, P; Boymatova, K; Braeckevelt, L; Braeckman, L; Bragt, MCE; Brajkovich, I; Branca, F; Breckenkamp, J; Breda, J; Brenner, H; Brewster, LM; Brian, GR; Briceño, Y; Brinduse, L; Brito, M; Brophy, S; Brug, J; Bruno, G; Bugge, A; Buntinx, F; Buoncristiano, M; Burazeri, G; Burns, C; de León, AC; Cacciottolo, J; Cai, H; Caixeta, RB; Cama, T; Cameron, C; Camolas, J; Can, G; Candido, APC; Cañete, F; 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Thomas, N; Thorand, B; Thuesen, BH; Tichá, L; Timmermans, EJ; Tjandrarini, DH; Tjonneland, A; Tolonen, HK; Tolstrup, JS; Topbas, M; Topór-Madry, R; Torheim, LE; Tormo, MJ; Tornaritis, MJ; Torrent, M; Torres-Collado, L; Toselli, S; Touloumi, G; Traissac, P; Tran, TTH; Tremblay, MS; Triantafyllou, A; Trichopoulos, D; Trichopoulou, A; Trinh, OTH; Trivedi, A; Tsao, YH; Tshepo, L; Tsigga, M; Tsintavis, P; Tsugane, S; Tuitele, J; Tuliakova, AM; Tulloch-Reid, MK; Tullu, F; Tuomainen, TP; Tuomilehto, J; Turley, ML; Twig, G; Tynelius, P; Tzala, E; Tzotzas, T; Tzourio, C; Ueda, P; Ugel, E; Ukoli, FAM; Ulmer, H; Unal, B; Usupova, Z; Uusitalo, HMT; Uysal, N; Vaitkeviciute, J; Valdivia, G; Vale, S; Valvi, D; van Dam, RM; van den Born, BJ; Van der Heyden, J; van der Schouw, YT; Van Herck, K; Van Lippevelde, W; Minh, HV; Van Schoor, NM; van Valkengoed, IGM; Vanderschueren, D; Vanuzzo, D; Varbo, A; Varela-Moreiras, G; Vargas, LN; Varona-Pérez, P; Vasan, SK; Vasques, DG; Vega, T; Veidebaum, T; Velasquez-Melendez, G; 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Yiallouros, PK; Yngve, A; Yoosefi, M; Yoshihara, A; You, QS; You, SL; Younger-Coleman, NO; Yu, YL; Yu, YJ; Yusof, SM; Yusoff, AF; Zaccagni, L; Zafiropulos, V; Zainuddin, AA; Zakavi, SR; Zamani, F; Zambon, S; Zampelas, A; Zamrazilova, H; Zapata, ME; Zargar, AH; Zaw, KK; Zayed, AA; Zdrojewski, T; Zeglen, M; Zejglicova, K; Vrkic, TZ; Zeng, Y; Zhang, LX; Zhang, ZY; Zhao, D; Zhao, MH; Zhao, WH; Zhecheva, YV; Zhen, SQ; Zheng, W; Zheng, YF; Zholdin, B; Zhou, MG; Zhu, D; Zins, M; Zitt, E; Zocalo, Y; Zoghlami, N; Cisneros, JZ; Zuziak, M; Bhutta, ZA; Black, RE; Ezzati, M

    NATURE   615 ( 7954 )   874 - 883   2023.3   ISSN:0028-0836 eISSN:1476-4687

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    Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being<sup>1–6</sup>. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m<sup>–2</sup> in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.

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  • The effect of the Kasuya CKD network on prevention of the progression of chronic kidney disease: successful collaboration of a public health service, primary care physicians and nephrologists-community based cohort study. Invited Reviewed International journal

    Katafuchi R, Tanaka S, Matsuo T, Tamai O, Yoshimine K, Yano K, Ueno K, Shimohashi N, Ninomiya T; Kasuya Chronic Kidney Disease Committee

    Clin Exp Nephrol   27   32 - 43   2023.3

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  • Association of gait speed with regional brain volumes and risk of dementia in older Japanese: the Hisayama Study. Invited Reviewed International journal

    Tajimi T, Furuta Y, Hirabayashi N, Honda T, Hata J, Ohara T, Shibata M, Nakao T, Kitazono T, Nakashima Y, Ninomiya T

    Arch Gerontol Geriatr   106   104883   2023.3

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  • Secular trends in the prevalence, incidence, and progression of diabetic retinopathy: the Hisayama Study. Invited Reviewed International journal

    Hashimoto S, Yasuda M, Fujiwara K, Ueda E, Nakamura S, Hirakawa Y, Higashioka M, Hata J, Ninomiya T, Sonoda KH

    Graefes Arch Clin Exp Ophthalmol   261   641 - 649   2023.3

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  • Diminishing benefits of urban living for children and adolescents' growth and development. Invited Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC)(Hata J, Ninomiya T)

    Nature   615   874 - 883   2023.3

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  • Seasonal variations in renal biopsy numbers and primary glomerular disease features based on the Japan renal biopsy registry. Invited Reviewed International journal

    Kanzaki G, Tsuboi N, Yokoo T, Uesugi N, Furuichi K, Shimizu A, Sugiyama H, Sato H, Yokoyama H; Committee for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology (Ninomiya T)

    Sci Rep   13   5123   2023.3

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  • Sex differences in risk factors for end-stage kidney disease and death in type 2 diabetes: a retrospective cohort study. Invited Reviewed International journal

    Oshima M, Iwata Y, Toyama T, Kitajima S, Hara A, Sakai N, Shimizu M, Furuichi K, Haneda M, Babazono T, Yokoyama H, Iseki K, Araki S, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Makino H, Wada T

    J Diabetes   15   246 - 254   2023.3

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  • Association of gait speed with regional brain volumes and risk of dementia in older Japanese: The Hisayama study. Reviewed International journal

    Takahiro Tajimi, Yoshihiko Furuta, Naoki Hirabayashi, Takanori Honda, Jun Hata, Tomoyuki Ohara, Mao Shibata, Tomohiro Nakao, Takanari Kitazono, Yasuharu Nakashima, Toshiharu Ninomiya

    Archives of gerontology and geriatrics   106   104883 - 104883   2023.3   ISSN:0167-4943 eISSN:1872-6976

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    BACKGROUND: To investigate the association of gait speed with regional brain volumes and the risk of incident dementia. METHODS: A total of 1112 dementia-free Japanese residents aged ≥65 years who underwent brain magnetic resonance imaging were followed for 5.0 years (median). The participants were classified into the age- and sex-specific quartile levels of maximum gait speed. Regional gray matter volumes (GMV) and white matter hyperintensities volumes (WMHV) were measured by applying voxel-based morphometry methods. The cross-sectional association of maximum gait speed with regional GMV was examined using an analysis of covariance. We also estimated the association between maximum gait speed level and the risk of developing dementia using a Cox proportional hazards model. Mediation analyses were conducted to determine the contribution of regional brain volumes to the association between maximum gait speed and dementia. RESULTS: Lower maximum gait speed was significantly associated with lower GMV of the total brain, frontal lobe, temporal lobe, cingulate gyrus, insula, hippocampus, amygdala, basal ganglia, thalamus, and cerebellum, and increased WMHV at baseline. During the follow-up, 108 participants developed dementia. The incidence rate of all dementias increased significantly with decreasing maximum gait speed after adjusting for potential confounders (P for trend = 0.03). The mediating effects of the GMV of the hippocampus, GMV of the insula, and WMHV were significant. CONCLUSIONS: Lower maximum gait speed was significantly associated with an increased risk of dementia. Reduced GMV of the hippocampus or insula, and an increase in WMHV was likely to be involved in this association.

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  • Sex differences in risk factors for end-stage kidney disease and death in type 2 diabetes: A retrospective cohort study. International journal

    Megumi Oshima, Yasunori Iwata, Tadashi Toyama, Shinji Kitajima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kengo Furuichi, Masakazu Haneda, Tetsuya Babazono, Hiroki Yokoyama, Kunitoshi Iseki, Shinichi Araki, Toshiharu Ninomiya, Shigeko Hara, Yoshiki Suzuki, Masayuki Iwano, Eiji Kusano, Tatsumi Moriya, Hiroaki Satoh, Hiroyuki Nakamura, Hirofumi Makino, Takashi Wada

    Journal of diabetes   15 ( 3 )   246 - 254   2023.3   ISSN:1753-0393 eISSN:1753-0407

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    BACKGROUND: This study investigated the sex differences in the risk of end-stage kidney disease (ESKD) and mortality, as well as the effect modification of sex on associated factors in patients with type 2 diabetes. METHODS: This multicenter observational cohort study included 4328 patients with type 2 diabetes. Hazard ratios (HRs) with 95% confidence intervals (CIs) of sex for ESKD and death were estimated using Cox proportional regression with adjustment for baseline covariates. For assessing risk modification, HRs and incidence rates for ESKD and death were compared between sexes across patient characteristics using Cox proportional and Poisson regression models. RESULTS: During a median follow-up of 7 years, 276 patients (70% men) developed ESKD, and 241 patients (68% men) died. Men had higher risks of ESKD (HR 1.34; 95% CI 1.02-1.75; p = .034) and death (HR 1.64; 95% CI 1.24-2.16; p = .001) versus women after adjusting for multiple covariates. Among patients with microalbuminuria, men had a substantially higher risk of ESKD versus women, compared to those with normo- and macroalbuminuria (p for interaction .04). Incidence rates were also increased in men versus women with albuminuria of around 300 mg/g. No differences were detected in the association of sex and death across baseline patient subgroups. CONCLUSIONS: In type 2 diabetes, men had an increased risk of ESKD and death versus women. Moderately increased albuminuria was strongly associated with sex difference in developing ESKD.

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  • Secular trends in the prevalence, incidence, and progression of diabetic retinopathy: the Hisayama Study

    Sawako Hashimoto, Miho Yasuda, Kohta Fujiwara, Emi Ueda, Shun Nakamura, Yoichiro Hirakawa, Mayu Higashioka, Jun Hata, Toshiharu Ninomiya, Koh-Hei Sonoda

    Graefe's Archive for Clinical and Experimental Ophthalmology   261 ( 3 )   641 - 649   2023.3   ISSN:0721-832X eISSN:1435-702X

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    Purpose: To examine the secular trends in the prevalence, incidence, and progression rates of diabetic retinopathy (DR) in a Japanese community. Methods: Community-dwelling Japanese residents aged ≥ 40 years with diabetes participated in comprehensive systemic and ophthalmological surveys, including an examination for DR, in 1998 (n = 220), 2007 (n = 511), 2012 (n = 515), and 2017 (n = 560). DR was assessed using colour fundus photographs after pupil dilation according to the modified Airlie House classification system. To compare the frequencies of newly developed or progressed DR between the studied decades, two eye cohorts were established (the 2000s cohort included 145 participants examined in 1998 and 2007; the 2010s cohort included 255 participants examined in 2007, 2012, and 2017). Trends in the prevalence, incidence, and progression rate of DR were tested by logistic regression analysis with a generalised estimating equation. Results: The age-adjusted prevalence of DR among individuals with diabetes decreased significantly with time from 1998 to 2017 (27.4% in 1998, 22.8% in 2007, 12.8% in 2012, and 6.4% in 2017; p for trend < 0.001). During this period, the prevalence of DR was decreasing in every haemoglobin A<inf>1c</inf> category, but it remained constant in the high systolic blood pressure category. In addition, the rates of new-onset of DR were significantly lower in the 2010s compared to the 2000s (p < 0.001). Conclusion: Our findings suggest that the prevalence and incidence of DR among diabetic people significantly decreased with time over the past two decades in a general Japanese population.

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  • Marital status, household size, and lifestyle changes during the first COVID-19 pandemic: NIPPON DATA2010

    Abe M., Arima H., Satoh A., Okuda N., Taniguchi H., Nishi N., Higashiyama A., Suzuki H., Kadota A., Ohkubo T., Ueshima H., Miura K., Okayama A., Saitoh S., Sakata K., Hozawa A., Nakamura Y., Okamura T., Murakami Y., Ojima T., Nakagawa H., Kita Y., Nakamura Y., Miyamatsu N., Hayakawa T., Yoshita K., Miyamoto Y., Watanabe M., Takashima N., Fujiyoshi A., Kodama K., Kasagi F., Kiyohara Y., Ninomiya T.

    Plos One   18 ( 3 March )   2023.3

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    Stay-at-home strategies taken during the COVID-19 pandemic changed our lifestyle drastically. Although marital status and household size are important social determinants of health that affect lifestyle, their impacts on lifestyle during the pandemic are still unclear. We aimed to evaluate the association between marital status, household size, and lifestyle changes during the first pandemic in Japan. Questionnaire surveys on lifestyle changes from before to during the first COVID-19 pandemic were conducted on October 2020 in Japan. Classified into age groups, multivariable logistic regression analysis was performed to examine the combined association of marital status and household size on lifestyle, adjusted for potential confounders including socioeconomic factors. In our prospective cohort study, 1928 participants were included. Among older participants, the singles living alone were likely to perceive more unhealthy lifestyle changes (45.8%), compared with the married (33.2%), and significantly associated with at least one unhealthy change [adjusted odds ratio (OR): 1.81, 95% confidence interval (CI): 1, 18-2.78], mainly due to decreased physical activity and increased alcohol consumption. Meanwhile, the younger participants showed no significant association between marital status, household size, and unhealthy changes, while those living alone had 2.87 times higher odds of weight gain (≥ 3 kg) than the married (adjusted OR: 2.87, 95% CI: 0.96-8.54) during the pandemic. Our findings suggest that older singles living alone are potentially vulnerable subgroups to drastic social changes which warrant special attention to prevent adverse health outcomes and additional burden on health systems in the following future.

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  • CKD, Brain Atrophy, and White Matter Lesion Volume: The Japan Prospective Studies Collaboration for Aging and Dementia. Reviewed International journal

    Kenji Maki, Tomoyuki Ohara, Jun Hata, Mao Shibata, Naoki Hirabayashi, Takanori Honda, Satoko Sakata, Yoshihiko Furuta, Masato Akiyama, Keisuke Yamasaki, Yasuko Tatewaki, Yasuyuki Taki, Takanari Kitazono, Tatsuya Mikami, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya

    Kidney medicine   5 ( 3 )   100593 - 100593   2023.3   ISSN:2590-0595

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    RATIONALE & OBJECTIVE: Chronic kidney disease, defined by albuminuria and/or reduced estimated glomerular filtration rate (eGFR), has been reported to be associated with brain atrophy and/or higher white matter lesion volume (WMLV), but there are few large-scale population-based studies assessing this issue. This study aimed to examine the associations between the urinary albumin-creatinine ratio (UACR) and eGFR levels and brain atrophy and WMLV in a large-scale community-dwelling older population of Japanese. STUDY DESIGN: Population-based cross-sectional study. SETTING & PARTICIPANTS: A total of 8,630 dementia-free community-dwelling Japanese aged greater than or equal to 65 years underwent brain magnetic resonance imaging scanning and screening examination of health status in 2016-2018. EXPOSURES: UACR and eGFR levels. OUTCOMES: The total brain volume (TBV)-to-intracranial volume (ICV) ratio (TBV/ICV), the regional brain volume-to-TBV ratio, and the WMLV-to-ICV ratio (WMLV/ICV). ANALYTICAL APPROACH: The associations of UACR and eGFR levels with the TBV/ICV, the regional brain volume-to-TBV ratio, and the WMLV/ICV were assessed by using an analysis of covariance. RESULTS: Higher UACR levels were significantly associated with lower TBV/ICV and higher geometric mean values of the WMLV/ICV (P for trend = 0.009 and <0.001, respectively). Lower eGFR levels were significantly associated with lower TBV/ICV, but not clearly associated with WMLV/ICV. In addition, higher UACR levels, but not lower eGFR, were significantly associated with lower temporal cortex volume-to-TBV ratio and lower hippocampal volume-to-TBV ratio. LIMITATIONS: Cross-sectional study, misclassification of UACR or eGFR levels, generalizability to other ethnicities and younger populations, and residual confounding factors. CONCLUSIONS: The present study demonstrated that higher UACR was associated with brain atrophy, especially in the temporal cortex and hippocampus, and with increased WMLV. These findings suggest that chronic kidney disease is involved in the progression of morphologic brain changes associated with cognitive impairment.

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  • II. Risk Assessment of Arteriosclerotic Disease in a General Population: the Hisayama Study

    Ninomiya Toshiharu

    Nihon Naika Gakkai Zasshi   112 ( 2 )   165 - 172   2023.2   ISSN:00215384 eISSN:18832083

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    <p>代謝性疾患の有病率の増加に伴い,冠動脈疾患に加えアテローム血栓性脳梗塞の予防の重要性が増している.そのため,これらの動脈硬化性疾患発症の絶対リスク評価に基づいた予防対策は有意義であるといえる.福岡県久山町で継続されている循環器疾患の前向きコホート研究(久山町研究)では,高い予測能を有する動脈硬化性疾患発症のリスク予測モデルを開発した.本稿では,このリスク予測モデルの作成の経緯と活用法を紹介する.</p>

    DOI: 10.2169/naika.112.165

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  • Genome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals International journal

    Masato Akiyama, Saori Sakaue, Atsushi Takahashi, Kazuyoshi Ishigaki, Makoto Hirata, Koichi Matsuda, Yukihide Momozawa, Yukinori Okada, Toshiharu Ninomiya, Masaru Koido, Takayuki Morisaki, Akiko Nagai, Yoji Sagiya, Chikashi Terao, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani

    Communications Biology   6 ( 1 )   143 - 143   2023.2   eISSN:2399-3642

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    Abstract

    Human lifespan is reported to be heritable. Although previous genome-wide association studies (GWASs) have identified several loci, a limited number of studies have assessed the genetic associations with the real survival information on the participants. We conducted a GWAS to identify loci associated with survival time in the Japanese individuals participated in the BioBank Japan Project by carrying out sex-stratified GWASs involving 78,029 males and 59,664 females. Of them, 31,324 (22.7%) died during the mean follow-up period of 7.44 years. We found a novel locus associated with survival (BET1L; P = 5.89 × 10<sup>−9</sup>). By integrating with eQTL data, we detected a significant overlap with eQTL of BET1L in skeletal muscle. A gene-set enrichment analysis showed that genes related to the BCAR1 protein–protein interaction subnetwork influence survival time (P = 1.54 × 10<sup>−7</sup>). These findings offer the candidate genes and biological mechanisms associated with human lifespan.

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  • Genome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals. Invited Reviewed International journal

    Akiyama M, Sakaue S, Takahashi A, Ishigaki K, Hirata M, Matsuda K, Momozawa Y, Okada Y, Ninomiya T; Biobank Japan project; Terao C, Murakami Y, Kubo M, Kamatani Y

    Commun Biol   6   143   2023.2

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  • Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts. International journal

    Kwok Leung Ong, Matti Marklund, Liping Huang, Kerry-Anne Rye, Nicholas Hui, Xiong-Fei Pan, Casey M Rebholz, Hyunju Kim, Lyn M Steffen, Anniek C van Westing, Johanna M Geleijnse, Ellen K Hoogeveen, Yun-Yu Chen, Kuo-Liong Chien, Amanda M Fretts, Rozenn N Lemaitre, Fumiaki Imamura, Nita G Forouhi, Nicholas J Wareham, Anna Birukov, Susanne Jäger, Olga Kuxhaus, Matthias B Schulze, Vanessa Derenji de Mello, Jaakko Tuomilehto, Matti Uusitupa, Jaana Lindström, Nathan Tintle, William S Harris, Keisuke Yamasaki, Yoichiro Hirakawa, Toshiharu Ninomiya, Toshiko Tanaka, Luigi Ferrucci, Stefania Bandinelli, Jyrki K Virtanen, Ari Voutilainen, Tharusha Jayasena, Anbupalam Thalamuthu, Anne Poljak, Sonia Bustamante, Perminder S Sachdev, Mackenzie K Senn 2nd, Stephen S Rich, Michael Y Tsai, Alexis C Wood, Markku Laakso, Maria Lankinen, Xiaowei Yang, Liang Sun, Huaixing Li, Xu Lin, Christoph Nowak, Johan Ärnlöv, Ulf Risérus, Lars Lind, Mélanie Le Goff, Cécilia Samieri, Catherine Helmer, Frank Qian, Renata Micha, Adrienne Tin, Anna Köttgen, Ian H de Boer, David S Siscovick, Dariush Mozaffarian, Jason Hy Wu

    BMJ (Clinical research ed.)   380   e072909   2023.1   ISSN:0959-535X eISSN:1756-1833

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    OBJECTIVE: To assess the prospective associations of circulating levels of omega 3 polyunsaturated fatty acid (n-3 PUFA) biomarkers (including plant derived α linolenic acid and seafood derived eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid) with incident chronic kidney disease (CKD). DESIGN: Pooled analysis. DATA SOURCES: A consortium of 19 studies from 12 countries identified up to May 2020. STUDY SELECTION: Prospective studies with measured n-3 PUFA biomarker data and incident CKD based on estimated glomerular filtration rate. DATA EXTRACTION AND SYNTHESIS: Each participating cohort conducted de novo analysis with prespecified and consistent exposures, outcomes, covariates, and models. The results were pooled across cohorts using inverse variance weighted meta-analysis. MAIN OUTCOME MEASURES: Primary outcome of incident CKD was defined as new onset estimated glomerular filtration rate <60 mL/min/1.73 m2. In a sensitivity analysis, incident CKD was defined as new onset estimated glomerular filtration rate <60 mL/min/1.73 m2 and <75% of baseline rate. RESULTS: 25 570 participants were included in the primary outcome analysis and 4944 (19.3%) developed incident CKD during follow-up (weighted median 11.3 years). In multivariable adjusted models, higher levels of total seafood n-3 PUFAs were associated with a lower incident CKD risk (relative risk per interquintile range 0.92, 95% confidence interval 0.86 to 0.98; P=0.009, I2=9.9%). In categorical analyses, participants with total seafood n-3 PUFA level in the highest fifth had 13% lower risk of incident CKD compared with those in the lowest fifth (0.87, 0.80 to 0.96; P=0.005, I2=0.0%). Plant derived α linolenic acid levels were not associated with incident CKD (1.00, 0.94 to 1.06; P=0.94, I2=5.8%). Similar results were obtained in the sensitivity analysis. The association appeared consistent across subgroups by age (≥60 v <60 years), estimated glomerular filtration rate (60-89 v ≥90 mL/min/1.73 m2), hypertension, diabetes, and coronary heart disease at baseline. CONCLUSIONS: Higher seafood derived n-3 PUFA levels were associated with lower risk of incident CKD, although this association was not found for plant derived n-3 PUFAs. These results support a favourable role for seafood derived n-3 PUFAs in preventing CKD.

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  • Late-Life High Blood Pressure and Enlarged Perivascular Spaces in the Putaminal Regions of Community-Dwelling Japanese Older Persons Invited Reviewed International journal

    Tachibana A, Iga JI, Tatewaki Y, Thyreau B, Chen H, Ozaki T, Yoshida T, Yoshino Y, Shimizu H, Mori T, Furuta Y, Shibata M, Ohara T, Hata J, Taki Y, Nakaji S, Maeda T, Ono K, Mimura M, Nakashima K, Takebayashi M, Ninomiya T, Ueno SI; JPSC-AD study group

    J Geriatr Psychiatry Neurol   37   61 - 72   2023.1

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  • Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts. Invited Reviewed International journal

    Ong KL, Marklund M, Huang L, Rye KA, Hui N, Pan XF, Rebholz CM, Kim H, Steffen LM, van Westing AC, Geleijnse JM, Hoogeveen EK, Chen YY, Chien KL, Fretts AM, Lemaitre RN, Imamura F, Forouhi NG, Wareham NJ, Birukov A, Jäger S, Kuxhaus O, Schulze MB, de Mell

    BMJ   380   2023.1

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  • The effect of the Kasuya CKD network on prevention of the progression of chronic kidney disease: successful collaboration of a public health service, primary care physicians and nephrologists-community based cohort study

    Katafuchi, R; Tanaka, S; Matsuo, T; Tamai, O; Yoshimine, K; Yano, K; Ueno, K; Shimohashi, N; Ninomiya, T

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   27 ( 1 )   32 - 43   2023.1   ISSN:1342-1751 eISSN:1437-7799

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    Background: In 2012, we established a CKD network in collaboration with the public health service, primary care physicians, and nephrologists in the Kasuya area. The aim of this study was to clarify if our CKD network was effective in preventing CKD progression. Methods: 1591 subjects, who had CKD in health checks in 2012 were included in this study. The slope of estimated glomerular filtration rate (eGFR) was compared before and after 2012. Parameters at the first health check visit before 2012, visit in 2012, and the last visit after 2012, were compared. Paired t test, analysis of variance for repeated measurements, and the Friedman test were used for the analysis. Results: Mean age was 65 years. There were 781 men and 810 women. Mean eGFR was 59 ml/min/1.73 m<sup>2</sup>. The mean slope of eGFR before 2012 was −1.833 ml/min/1.73 m<sup>2</sup>/year and significantly reduced to − 0.297 after 2012. Low-density lipoprotein cholesterol showed a significant serial lowering. Uric acid was significantly elevated in 2012 compared to the first visit and had decreased by the last. The dipstick urinary protein significantly increased in 2012 compared to the first visit and decreased by the last. The number of current smokers showed a significant reduction over time. On the other hand, systolic blood pressure (SBP) and HbA1c significantly elevated at the last visit. Conclusion: The Kasuya CKD network may be effective in preventing CKD progression.

    DOI: 10.1007/s10157-022-02267-0

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  • 粕屋地区CKD対策連携システムが慢性腎臓病の進行予防に与える影響 公的保健サービス、一次診療医、腎臓科医の有効な連携(地域住民コホート研究)(The effect of the Kasuya CKD network on prevention of the progression of chronic kidney disease: successful collaboration of a public health service, primary care physicians and nephrologists-community based cohort study)

    Katafuchi Ritsuko, Tanaka Shigeru, Matsuo Takayuki, Tamai Osamu, Yoshimine Kazuhiro, Yano Kazutoshi, Ueno Kiichiro, Shimohashi Naoya, Ninomiya Toshiharu

    Clinical and Experimental Nephrology   27 ( 1 )   32 - 43   2023.1   ISSN:1342-1751

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    粕屋地区CKD対策連携システムは、福岡県の粕屋地区で公的保健サービス、一次診療医、腎臓科医が連携し慢性腎臓病(CKD)の進行予防を目指すネットワークとして2012年に設立された。本研究では、上記システムの効果を明らかにした。2012年に健康診断を受けたCKD罹患の被検者1591名(女性810名、平均65±7歳)を組み入れた。推算糸球体濾過量(eGFR)の平均値は59mL/分/1.73m2であった。2012年以前で最初の健康診断受診時と、2012年以後の最直近の受診時の結果も加えてeGFRの変化速度を計算した。その結果、2012年以前の時期では-1.83mL/分/1.73m2/年であったが、2012年以後では-0.30mL/分/1.73m2/年と、その低下速度は緩やかになっていた。低比重リポ蛋白(LDL)コレステロール値は経時的にみて有意に低下していた。尿酸値、および尿試験紙による尿蛋白は初回受診時に比べ2012年には有意に増高し、最直近の受診時までには低減していた。現喫煙者数は全期間を通じて有意に減少していた。収縮期血圧とHbA1c値は最直近の受診時において有意な上昇が示されていた。粕屋地区CKD対策連携システムはCKD進行予防に効果があると考えられた。

  • Distractor Generation for Fill-in-the-Blank Exercises by Question Type

    Yoshimi, N; Kajiwara, T; Uchida, S; Arase, Y; Ninomiya, T

    PROCEEDINGS OF THE 61ST ANNUAL MEETING OF THE ASSOCIATION FOR COMPUTATIONAL LINGUISTICS, ACL-SRW 2023, VOL 4   276 - 281   2023   ISBN:978-1-959429-69-2

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  • 久山町研究

    Ohara Tomoyuki, Ninomiya Toshiharu

    Japanese Journal of Biological Psychiatry   34 ( 1 )   38 - 40   2023   ISSN:21866619 eISSN:21866465

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    DOI: 10.11249/jsbpjjpp.34.1_38

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  • 認知症の地域疫学研究:久山町研究

    二宮 利治

    Neurological Therapeutics   40 ( 6 )   S167 - S167   2023   ISSN:09168443 eISSN:21897824

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    DOI: 10.15082/jsnt.40.6_s167

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  • Long-Term Trends in The 5-Year Risk of Recurrent Stroke over A Half Century in A Japanese Community: The Hisayama Study

    Nakanishi Yasuyuki, Furuta Yoshihiko, Hata Jun, Yubi Tomohiro, Oishi Emi, Sakata Satoko, Hirakawa Yoichiro, Wakisaka Yoshinobu, Ago Tetsuro, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   29 ( 12 )   1759 - 1773   2022.12   ISSN:13403478 eISSN:18803873

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japan Atherosclerosis Society  

    <p> <b>Aim:</b> Secular trends in the risk of recurrent stroke have been reported in several epidemiological studies worldwide, but this issue has not been investigated in general Japanese populations. We examined the trends in the 5-year risk of recurrent stroke over a half century using community-based prospective data in Japan.</p><p><b>Methods:</b> We established 4 cohort studies in 1961, 1974, 1988, and 2002. To examine the risk of recurrent stroke, participants who developed stroke during a 10-year follow-up period in each cohort were followed-up for 5 years from the date of first onset. A total of 154 (first sub-cohort: 1961-1971), 144 (second sub-cohort: 1974-1984), 172 (third sub-cohort: 1988-1998), and 146 (fourth sub-cohort: 2002-2012) participants from each cohort were enrolled in the present study. The 5-year cumulative risk of recurrent stroke was compared among the sub-cohorts using the Kaplan-Meier method and the age- and sex-adjusted Cox proportional hazards model.</p><p><b>Results:</b> The risks of recurrent stroke after any stroke and ischemic stroke decreased significantly from the first to the third sub-cohort, but they did not clearly change from the third to the fourth sub-cohort. The risk of recurrent stroke after hemorrhagic stroke decreased mainly from the first to the second sub-cohort and there was no apparent decrease from the second to the fourth sub-cohort. These trends were substantially unchanged after adjusting for age and sex.</p><p><b>Conclusions:</b> In the Japanese community, the risk of recurrent stroke decreased mainly from the 1960s to 1990s, but there was no apparent decrease in recent years.</p>

    DOI: 10.5551/jat.63344

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  • CKD, brain atrophy, and white matter lesion volume: the Japan prospective studies collaboration for aging and dementia. Invited Reviewed International journal

    Maki K, Ohara T, Hata J, Shibata M, Hirabayashi N, Honda T, Sakata S, Furuta Y, Akiyama M, Yamasaki K, Tatewaki Y, Taki Y, Kitazono T, Mikami T, Maeda T, Ono K, Mimura M, Nakashima K, Iga JI, Takebayashi M, Ninomiya T; Japan Prospective Studies Collaborat

    Kidney Med   5   100593   2022.12

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  • Long-term trends in the 5-year risk of recurrent stroke over a half century in a Japanese community: the Hisayama Study. Invited Reviewed International journal

    Nakanishi Y, Furuta Y, Hata J, Yubi T, Oishi E, Sakata S, Hirakawa Y, Wakisaka Y, Ago T, Kitazono T, Ninomiya T

    J Atheroscler Thromb   29   1759 - 1773   2022.12

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  • 日本の一地域で半世紀にわたり示された再発性脳卒中5年リスクの長期傾向 久山町研究(Long-Term Trends in The 5-Year Risk of Recurrent Stroke over A Half Century in A Japanese Community: The Hisayama Study)

    Nakanishi Yasuyuki, Furuta Yoshihiko, Hata Jun, Yubi Tomohiro, Oishi Emi, Sakata Satoko, Hirakawa Yoichiro, Wakisaka Yoshinobu, Ago Tetsuro, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   29 ( 12 )   1759 - 1773   2022.12   ISSN:1340-3478

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    一般日本人集団の前向き追跡データを用いて、再発性脳卒中の5年リスクにみられる傾向を半世紀にわたり検討した。福岡県久山町の住民を対象に、1961年から続けられている久山町研究のデータを利用した。1961年(154名)、1974年(144名)、1988年(172名)、2002年(146名)を起点とする四つのコホートを設定し、脳卒中発症患者を起点から10年間追跡したデータを用いて再発性脳卒中リスクを調査した。全種類の脳卒中および虚血性脳卒中を発症した後の再発性脳卒中リスクは、一番目(1961年)のコホートから三番目のコホートにかけて有意に低下していたが、三番目から四番目のコホートでは明瞭な変化は示されなかった。出血性脳卒中後の同リスクは主として一番目から二番目のコホートにかけて低下しており、二番目から四番目まででは明らかな低下はみられなかった。こうした傾向は年齢・性別で調整しても実質的に不変であった。

  • Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses

    Gaziano, L; Sun, L; Arnold, M; Bell, S; Cho, K; Kaptoge, SK; Song, RJ; Burgess, S; Posner, DC; Mosconi, K; Cohen, CR; Mason, AM; Bolton, TR; Tao, R; Allara, E; Schubert, P; Chen, L; Staley, JR; Staplin, N; Altay, S; Amiano, P; Arndt, PV; Ärnlöv, J; Barr, ELM; Björkelund, C; Boer, JMA; Brenner, H; Casiglia, E; Chiodini, P; Cooper, JA; Coresh, J; Cushman, M; Dankner, R; Davidson, KW; de Jongh, RT; Donfrancesco, C; Engström, G; Freisling, H; de la Cámara, AG; Gudnason, V; Hankey, GJ; Hansson, P; Heath, AK; Hoorn, EJ; Imano, H; Jassal, SK; Kaaks, R; Katzke, V; Kauhanen, J; Kiechl, S; Koenig, W; Kronmal, RA; Kyro, C; Lawlor, DA; Ljungberg, B; MacDonald, C; Masala, G; Meisinger, C; Melander, O; Iribas, CM; Ninomiya, T; Nitsch, D; Nordestgaard, BG; OnlandMoret, C; Palmieri, L; Petrova, D; Garcia, JRQ; Rosengren, A; Sacerdote, C; Sakurai, M; Santiuste, C; Schulze, MB; Sieri, S; Sundström, J; Tikhonoff, V; Tjonneland, A; Tong, T; Tumino, R; Tzoulaki, I; van der Schouw, YT; Verschuren, WMM; Völzke, H; Wallace, RB; Wannamethee, SG; Weiderpass, E; Willeit, P; Woodward, M; Yamagishi, K; ZamoraRos, R; Akwo, EA; Pyarajan, S; Gagnon, DR; Tsao, PS; Muralidhar, S; Edwards, TL; Damrauer, SM; Joseph, J; Pennells, L; Wilson, PWF; Harrison, S; Gaziano, TA; Inouye, M; Baigent, C; Casas, JP; Langenberg, C; Wareham, N; Riboli, E; Gaziano, JM; Danesh, J; Hung, AM; Butterworth, AS; Wood, AM; Di Angelantonio, E

    CIRCULATION   146 ( 20 )   1507 - 1517   2022.11   ISSN:0009-7322 eISSN:1524-4539

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    Background: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke. Methods: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and Nutrition-Cardiovascular Disease Study], Million Veteran Program, and UK Biobank), comprising 648 135 participants with no history of cardiovascular disease or diabetes at baseline, yielding 42 858 and 15 693 incident CHD and stroke events, respectively, during 6.8 million person-years of follow-up. Using a genetic risk score of 218 variants for estimated glomerular filtration rate (eGFR), we conducted Mendelian randomization analyses involving 413 718 participants (25 917 CHD and 8622 strokes) in EPIC-CVD, Million Veteran Program, and UK Biobank. Results: There were U-shaped observational associations of creatinine-based eGFR with CHD and stroke, with higher risk in participants with eGFR values <60 or >105 mL·min-1·1.73 m-2, compared with those with eGFR between 60 and 105 mL·min-1·1.73 m-2. Mendelian randomization analyses for CHD showed an association among participants with eGFR <60 mL·min-1·1.73 m-2, with a 14% (95% CI, 3%-27%) higher CHD risk per 5 mL·min-1·1.73 m-2 lower genetically predicted eGFR, but not for those with eGFR >105 mL·min-1·1.73 m-2. Results were not materially different after adjustment for factors associated with the eGFR genetic risk score, such as lipoprotein(a), triglycerides, hemoglobin A1c, and blood pressure. Mendelian randomization results for stroke were nonsignificant but broadly similar to those for CHD. Conclusions: In people without manifest cardiovascular disease or diabetes, mild-to-moderate kidney dysfunction is causally related to risk of CHD, highlighting the potential value of preventive approaches that preserve and modulate kidney function.

    DOI: 10.1161/CIRCULATIONAHA.122.060700

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  • Stroke genetics informs drug discovery and risk prediction across ancestries

    Mishra, A; Malik, R; Hachiya, T; Jurgenson, T; Namba, S; Posner, DC; Kamanu, FK; Koido, M; Le Grand, Q; Shi, MY; He, YY; Georgakis, MK; Caro, I; Krebs, K; Liaw, YC; Vaura, FC; Lin, K; Winsvold, BS; Srinivasasainagendra, V; Parodi, L; Bae, HJ; Chauhan, G; Chong, MR; Tomppo, L; Akinyemi, R; Roshchupkin, GV; Habib, N; Jee, YH; Thomassen, JQ; Abedi, V; Carcel-Marquez, J; Nygaard, M; Leonard, HL; Yang, CJ; Yonova-Doing, E; Knol, MJ; Lewis, AJ; Judy, RL; Ago, T; Amouyel, P; Armstrong, ND; Bakker, MK; Bartz, TM; Bennett, DA; Bis, JC; Bordes, C; Borte, S; Cain, A; Ridker, PM; Cho, K; Chen, ZM; Cruchaga, C; Cole, JW; de Jager, PL; de Cid, R; Endres, M; Ferreira, LE; Geerlings, MI; Gasca, NC; Gudnason, V; Hata, J; He, J; Heath, AK; Ho, YL; Havulinna, AS; Hopewell, JC; Hyacinth, HI; Inouye, M; Jacob, MA; Jeon, CE; Jern, C; Kamouchi, M; Keene, KL; Kitazono, T; Kittner, SJ; Konuma, T; Kumar, A; Lacaze, P; Launer, LJ; Lee, KJ; Lepik, K; Li, J; Li, LM; Manichaikul, A; Markus, HS; Marston, NA; Meitinger, T; Mitchell, BD; Montellano, FA; Morisaki, T; Mosley, TH; Nalls, MA; Nordestgaard, BG; O'Donnell, MJ; Okada, Y; Onland-Moret, NC; Ovbiagele, B; Peters, A; Psaty, BM; Rich, SS; Rosand, J; Sabatine, MS; Sacco, RL; Saleheen, D; Sandset, EC; Salomaa, V; Sargurupremraj, M; Sasaki, M; Satizabal, CL; Schmidt, CO; Shimizu, A; Smith, NL; Sloane, KL; Sutoh, Y; Sun, YV; Tanno, K; Tiedt, S; Tatlisumak, T; Torres-Aguila, NP; Tiwari, HK; Tregouet, DA; Trompet, S; Tuladhar, AM; Tybjaerg-Hansen, A; van Vugt, M; Vibo, R; Verma, SS; Wiggins, KL; Wennberg, P; Woo, D; Wilson, PWF; Xu, HC; Yang, Q; Yoon, K; Millwood, IY; Gieger, C; Ninomiya, T; Grabe, HJ; Jukema, JW; Rissanen, IL; Strbian, D; Kim, YJ; Chen, PH; Mayerhofer, E; Howson, JMM; Irvin, MR; Adams, H; Wassertheil-Smoller, S; Christensen, K; Ikram, MA; Rundek, T; Worrall, BB; Lathrop, GM; Riaz, M; Simonsick, EM; Korv, J; Franca, PHC; Zand, R; Prasad, K; Frikke-Schmidt, R; de Leeuw, FE; Liman, T; Haeusler, KG; Ruigrok, YM; Heuschmann, PU; Longstreth, WT; Jung, KJ; Bastarache, L; Pare, G; Damrauer, SM; Chasman, DI; Rotter, JI; Anderson, CD; Zwart, JA; Niiranen, TJ; Fornage, M; Liaw, YP; Seshadri, S; Fernandez-Cadenas, I; Walters, RG; Ruff, CT; Owolabi, MO; Huffman, JE; Milani, L; Kamatani, Y; Dichgans, M; Debette, S; Lee, JM; Cheng, YC; Meschia, JF; Chen, WM; Sale, MM; Zonderman, AB; Evans, MK; Wilson, JG; Correa, A; Traylor, M; Lewis, CM; Reiner, A; Haessler, J; Langefeld, CD; Gottesman, RF; Yaffe, K; Liu, YM; Kooperberg, C; Lange, LA; Furie, KL; Arnett, DK; Benavente, OR; Grewal, RP; Peddareddygari, LR; Hveem, K; Lindstrom, S; Wang, L; Smith, EN; Gordon, W; Vlieg, AV; de Andrade, M; Brody, JA; Pattee, JW; Brumpton, BM; Suchon, P; Chen, MH; Frazer, KA; Turman, C; Germain, M; MacDonald, J; Braekkan, SK; Armasu, SM; Pankratz, N; Jackson, RD; Nielsen, JB; Giulianin, F; Puurunen, MK; Ibrahim, M; Heckbert, SR; Bammler, TK; McCauley, BM; Taylor, KD; Pankow, JS; Reiner, AP; Gabrielsen, ME; Deleuze, JF; O'Donnell, CJ; Kim, J; McKnight, B; Kraft, P; Hansen, JB; Rosendaal, FR; Heit, JA; Tang, WH; Morange, PE; Johnson, AD; Kabrhel, C; van Dijk, EJ; Koudstaal, PJ; Luijckx, GJ; Nederkoorn, PJ; van Oostenbrugge, RJ; Visser, MC; Wermer, MJH; Kappelle, LJ; Esko, T; Metspalu, A; Magi, R; Nelis, M; Levi, CR; Maguire, J; Jimenez-Conde, J; Sharma, P; Sudlow, CLM; Rannikmae, K; Schmidt, R; Slowik, A; Pera, J; Thijs, VNS; Lindgren, AG; Ilinca, A; Melander, O; Engstrom, G; Rexrode, KM; Rothwell, PM; Stanne, TM; Johnson, JA; Danesh, J; Butterworth, AS; Heitsch, L; Boncoraglio, GB; Kubo, M; Pezzini, A; Rolfs, A; Giese, AK; Weir, D; Ross, OA; Lemmons, R; Soderholm, M; Cushman, M; Jood, K; McDonough, CW; Bell, S; Linkohr, B; Lee, TH; Putaala, J; Lopez, OL; Carty, CL; Jian, XQ; Schminke, U; Cullell, N; Delgado, P; Ibañez, L; Krupinski, J; Lioutas, V; Matsuda, K; Montaner, J; Muiño, E; Roquer, J; Sarnowski, C; Sattar, N; Sibolt, G; Teumer, A; Rutten-Jacobs, L; Kanai, M; Gretarsdottir, S; Rost, NS; Yusuf, S; Almgren, P; Ay, H; Bevan, S; Brown, RD ; Carrera, C; Buring, JE; Chen, WM; Cotlarciuc, I; de Bakker, PIW; DeStefano, AL; den Hoed, M; Duan, Q; Engelter, ST; Falcone, GJ; Gustafsson, S; Hassan, A; Holliday, EG; Howard, G; Hsu, FC; Ingelsson, E; Harris, TB; Kissela, BM; Kleindorfer, DO; Langenberg, C; Leys, D; Lin, WY; Lorentzen, E; Magnusson, PK; McArdle, PF; Pulit, SL; Rice, K; Sakaue, S; Sapkota, BR; Tanislav, C; Thorleifsson, G; Thorsteinsdottir, U; Tzourio, C; van Duijn, CM; Walters, M; Wareham, NJ; Amin, N; Aparicio, HJ; Attia, J; Beiser, AS; Berr, C; Bustamante, M; Caso, V; Choi, SH; Chowhan, A; Dartigues, JF; Delavaran, H; Dörr, M; Ford, I; Gurpreet, WS; Hamsten, A; Hozawa, A; Ingelsson, M; Iwasaki, M; Kaffashian, S; Kalra, L; Kjartansson, O; Kloss, M; Labovitz, DL; Laurie, CC; Li, LX; Lind, L; Lindgren, CM; Makoto, H; Minegishi, N; Morris, AP; Müller-Nurasyid, M; Norrving, B; Ogishima, S; Parati, EA; Pedersen, NL; Perola, M; Jousilahti, P; Pileggi, S; Rabionet, R; Riba-Llena, I; Ribasés, M; Romero, JR; Rudd, AG; Sarin, AP; Sarju, R; Satoh, M; Sawada, N; Sigurdsson, A; Smith, A; Stine, OC; Stott, DJ; Strauch, K; Takai, T; Tanaka, H; Touze, E; Tsugane, S; Uitterlinden, AG; Valdimarsson, EM; van der Lee, SJ; Wakai, K; Williams, SR; Wolfe, CDA; Wong, Q; Yamaji, T; Sanghera, DK; Stefansson, K; Martinez-Majander, N; Sobue, K; Soriano-Tárraga, C; Völzke, H; Akpa, O; Sarfo, FS; Akpalu, A; Obiako, R; Wahab, K; Osaigbovo, G; Owolabi, L; Komolafe, M; Jenkins, C; Arulogun, O; Ogbole, G; Adeoye, AM; Akinyemi, J; Agunloye, A; Fakunle, AG; Uvere, E; Olalere, A; Adebajo, OJ; Chen, JS; Clarke, R; Collins, R; Guo, Y; Wang, C; Lv, J; Peto, R; Chen, YP; Fairhurst-Hunter, Z; Hill, M; Pozarickij, A; Schmidt, D; Stevens, B; Turnbull, I; Yu, CQ; Nagai, A; Murakami, Y; Shiroma, EJ; Sigurdsson, ,S; Ghanbari, M; Boerwinkle, E; Fongang, B; Wang, RQ; Ikram, MK; Völker, U; de Laat, KF; van Norden, AGW; de Kort, PL; Vermeer, SE; Brouwers, PJAM; Gons, RAR; den Heijer, T; van Dijk, GW; van Rooij, FGW; Aamodt, AH; Skogholt, AH; Willer, CJ; Heuch, I; Hagen, K; Fritsche, LG; Pedersen, LM; Ellekjær, H; Zhou, W; Martinsen, AE; Kristoffersen, ES; Thomas, LF; Kleinschnitz, C; Frantz, S; Ungethüm, K; Gallego-Fabrega, C; Lledós, M; Llucià-Carol, L; Sobrino, T; Campos, F; Castillo, J; Freijó, M; Arenillas, JF; Obach, V; Alvarez-Sabín, J; Molina, CA; Ribó, M; Muñoz-Narbona, L; Lopez-Cancio, E; Millán, M; Diaz-Navarro, R; Vives-Bauza, C; Serrano-Heras, G; Segura, T; Dhar, R; Delgado-Mederos, R; Prats-Sánchez, L; Camps-Renom, P; Blay, N; Sumoy, L; Martí-Fàbregas, J; Schnohr, P; Jensen, GB; Benn, M; Afzal, S; Kamstrup, PR; van Setten, J; van der Laan, SW; Vonk, JMJ; Kim, BJ; Curtze, S; Tiainen, M; Kinnunen, J; Menon, V; Sung, YJ; Yang, CR; Saillour-Glenisson, F; Gravel, S

    NATURE   611 ( 7934 )   115 - +   2022.11   ISSN:0028-0836 eISSN:1476-4687

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    Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry<sup>1,2</sup>. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis<sup>3</sup>, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach<sup>4</sup>, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry<sup>5</sup>. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.

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  • Mild-to-Moderate kidney dysfunction and cardiovascular disease: observational and mendelian randomization analyses. Invited Reviewed International journal

    Gaziano L, Sun L, Arnold M, Bell S, Cho K, Kaptoge SK, Song RJ, Burgess S, Posner DC, Mosconi K, Robinson-Cohen C, Mason AM, Bolton TR, Tao R, Allara E, Schubert P, Chen L, Staley JR, Staplin N, Altay S, Amiano P, Arndt V, Ärnlöv J, Barr ELM, Björkelund C

    Circulation 146: 1507-1517, 2022   1507 - 1517   2022.11

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  • Association between chronic low back pain and regional brain atrophy in a Japanese older population: the Hisayama Study. Invited Reviewed International journal

    Asada M, Shibata M, Hirabayashi N, Ohara T, Furuta Y, Nakazawa T, Honda T, Hata J, Hosoi M, Sudo N, Yamaura K, Ninomiya T

    Pain   163   2185 - 2193   2022.11

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  • Current antihypertensive treatment and treatment-resistant hypertension in Japanese patients with chronic kidney disease. Invited Reviewed International journal

    Tsuchimoto A, Tanaka S, Kitamura H, Hiyamuta H, Tsuruya K, Kitazono T, Nakano T; Fukuoka Kidney disease Registry (FKR) study corporation( Ninomiya T, Nagata M)

    Clin Exp Nephrol   26   1100 - 1110   2022.11

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  • Prevalence of glaucoma and its systemic risk factors in a general Japanese population: the Hisayama Study. Invited Reviewed International journal

    Fujiwara K, Yasuda M, Hata J, Nakano S, Hashimoto S, Ueda E, Nakamura S, Murakami Y, Nakamuro T, Iwase A, Araie M, Tawara A, Kubota T, Yoshitomi T, Ninomiya T, Sonoda KH

    Transl Vis Sci Technol   11 ( 11 )   2022.11

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  • Current antihypertensive treatment and treatment-resistant hypertension in Japanese patients with chronic kidney disease

    Tsuchimoto A., Tanaka S., Kitamura H., Hiyamuta H., Tsuruya K., Kitazono T., Nakano T., Fujimi S., Hirakata H., Hirano T., Yoshida T., Deguchi T., Mitsuiki K., Fujisaki K., Tokumoto M., Nakai K., Nagashima A., Katafuchi R., Kanai H., Harada K., Mizumasa T., Ninomiya T., Torisu K., Yamada S., Matsuo D., Kuroki Y., Nagae H., Nakayama M., Nagata M., Yanagida T., Ohnaka S.

    Clinical and Experimental Nephrology   26 ( 11 )   1100 - 1110   2022.11   ISSN:13421751

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    Background: Hypertension is an important prognostic predictor in patients with chronic kidney disease (CKD), and the recommended target blood pressure has been continuously revised. This study aimed to reveal the current antihypertensive practices in Japanese patients with CKD. Methods: In the Fukuoka Kidney disease Registry, we extracted 3664 non-dialysis-dependent patients with CKD. Apparent treatment-resistant hypertension (aTRH) was defined as a failure of blood-pressure control treated with three antihypertensive medication classes or a treatment with ≥ 4 classes regardless of blood pressure. The blood-pressure control complied with the target blood pressure recommended by the KDIGO 2012 guideline. Results: The median age of the patients was 67 years, body mass index (BMI) was 23 kg/m<sup>2</sup>, and estimated glomerular filtration rate (eGFR) was 40 mL/min/1.73 m<sup>2</sup>. The number of patients with unachieved blood-pressure control was 1933, of whom 26% received ≥ 3 classes of antihypertensive medications. The first choice of medication was renin–angiotensin system inhibitors, followed by calcium-channel blockers. The rate of thiazide use was low in all CKD stages (3–11%). The prevalence of aTRH was 16%, which was significantly associated with BMI (odds ratio [95% confidence interval] per 1-standard deviation change, 1.38 [1.25–1.53]), decreased eGFR (1.87 [1.57–2.23]), as well as age, diabetes mellitus, and chronic heart disease. Conclusions: Renal dysfunction and obesity are important risk factors of aTRH. Even under nephrologist care, most patients were treated with insufficient antihypertensive medications. It is important to prescribe sufficient classes of antihypertensive medications, including diuretics, and to improve patients’ lifestyle habits.

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  • Association between chronic low back pain and regional brain atrophy in a Japanese older population: the Hisayama Study. International journal

    Masako Asada, Mao Shibata, Naoki Hirabayashi, Tomoyuki Ohara, Yoshihiko Furuta, Taro Nakazawa, Takanori Honda, Jun Hata, Masako Hosoi, Nobuyuki Sudo, Ken Yamaura, Toshiharu Ninomiya

    Pain   163 ( 11 )   2185 - 2193   2022.11   ISSN:0304-3959 eISSN:1872-6623

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    ABSTRACT: Chronic low back pain (CLBP) is the leading cause of years lived with disability. Recently, it has been reported that CLBP is associated with alterations in the central nervous system. The present study aimed to investigate the association between CLBP and regional brain atrophy in an older Japanese population. A total of 1106 community-dwelling participants aged ≥65 years underwent brain magnetic resonance imaging scans and a health examination in 2017 to 2018. We used the FreeSurfer software for the analysis of brain magnetic resonance imaging. Chronic pain was defined as subjective pain for ≥3 months. Participants were divided into 3 groups according to the presence or absence of chronic pain and the body part that mainly suffered from pain: a "no chronic pain (NCP)" group (n = 541), "CLBP" group (n = 189), and "chronic pain in body parts other than the lower back (OCP)" group (n = 376). The brain volumes of the ventrolateral and dorsolateral prefrontal cortex, the posterior cingulate gyrus, and the amygdala were significantly lower in the CLBP group than in the NCP group after adjustment for sociodemographic, physical, and lifestyle factors and depressive symptoms. In addition, the left superior frontal gyrus was identified as a significant cluster by the Query, Design, Estimate, Contrast interface. There were no significant differences in the brain volumes of pain-related regions between the NCP and the OCP groups. The present study suggests that CLBP is associated with lower brain volumes of pain-related regions in a general older population of Japanese.

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  • Chronological Changes in the Expression Pattern of Hippocampal Prion Proteins During Disease Progression in Sporadic Creutzfeldt-Jakob Disease MM1 Subtype

    Yagita, K; Noguchi, H; Koyama, S; Hamasaki, H; Komori, T; Aishima, S; Kosaka, T; Ueda, M; Komohara, Y; Watanabe, A; Sasagasako, N; Ninomiya, T; Oda, Y; Honda, H

    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY   81 ( 11 )   900 - 909   2022.10   ISSN:0022-3069 eISSN:1554-6578

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    The differential effects of sporadic Creutzfeldt-Jakob disease (sCJD) on the hippocampus and other neocortical areas are poorly understood. We aimed to reveal the histological patterns of cellular prion protein (PrPC) and abnormal prion protein (PrPSc) in hippocampi of sCJD patients and normal controls (NCs). Our study examined 18 postmortem sCJD patients (MM1, 14 cases; MM1 + 2c, 3 cases; MM1 + 2t, 1 case) and 12 NCs. Immunohistochemistry was conducted using 4 primary antibodies, of which 3 targeted the N-terminus of the prion protein (PrP), and 1 (EP1802Y) targeted the C-terminal domain. PrPC expression was abundant in the hippocampus of NCs, and the distribution of PrPC at CA3/4 was reminiscent of synaptic complexes. In sCJD cases with a disease history of <2 years, antibodies against the N-terminus could not detect synapse-like PrP expression at CA4; however, EP1802Y could characterize the synapse-like expression. PrPSc accumulation and spongiform changes became evident after 2 years of illness, when PrPSc deposits were more noticeably detected by N-terminal-specific antibodies. Our findings highlighted the chronology of histopathological alterations in the CA4 region in sCJD patients.

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  • 特集 認知症施策up to date 地域疫学研究の成果から見た認知症リスク低減の可能性-久山町研究

    二宮 利治

    公衆衛生   86 ( 10 )   816 - 824   2022.10   ISSN:03685187 eISSN:18821170

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    DOI: 10.11477/mf.1401209919

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  • Day-to-Day Blood Pressure Variability and Risk of Incident Chronic Kidney Disease in a General Japanese Population. Reviewed International journal

    Takaya Sasaki, Satoko Sakata, Emi Oishi, Yoshihiko Furuta, Takanori Honda, Jun Hata, Nobuo Tsuboi, Takanari Kitazono, Takashi Yokoo, Toshiharu Ninomiya

    Journal of the American Heart Association   11 ( 19 )   e027173   2022.10   eISSN:2047-9980

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    Background Several longitudinal studies have reported that higher visit-to-visit blood pressure variability is associated with greater risk for developing chronic kidney disease. However, no population-based studies have investigated the association between day-to-day home blood pressure variability and incident chronic kidney disease. Methods and Results A total of 2342 Japanese community-dwelling residents aged ≥40 years without chronic kidney disease at baseline were followed up by annual health examinations for 10 years. Home blood pressure was measured 3 times every morning for 28 days. Day-to-day coefficients of variation of home systolic blood pressure levels were categorized into quintiles. Chronic kidney disease was defined as an estimated glomerular filtration rate <60 mL/min per 1.73 m2 or the presence of proteinuria. The hazard ratios for developing chronic kidney disease were estimated with a Cox proportional hazards model. During the follow-up period, 772 participants developed chronic kidney disease. Increased coefficients of variation of home systolic blood pressure were associated significantly with higher risk of chronic kidney disease after adjusting for confounders (P for trend <0.001): Individuals in the highest quintile of coefficients of variation had a 1.50-fold (95% CI, 1.17-1.94) greater risk of developing chronic kidney disease than those in the lowest quintile. The combination of higher coefficients of variation and higher mean value of home systolic blood pressure was associated with the multivariable-adjusted risk of developing chronic kidney disease. Conclusions These findings suggest that increased day-to-day blood pressure variability is a significant risk factor for developing chronic kidney disease in a general Japanese population.

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  • Chronological changes in the expression pattern of hippocampal prion proteins during disease progression in sporadic Creutzfeldt-Jakob disease MM1 subtype. Invited Reviewed International journal

    Yagita K, Noguchi H, Koyama S, Hamasaki H, Komori T, Aishima S, Kosaka T, Ueda M, Komohara Y, Watanabe A, Sasagasako N, Ninomiya T, Oda Y, Honda H

    J Neuropathol Exp Neurol   81   900 - 909   2022.10

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  • Active commuting, commuting modes and the risk of diabetes: 14-year follow-up data from the Hisayama study. Invited Reviewed International journal

    Honda T, Hirakawa Y, Hata J, Chen S, Shibata M, Sakata S, Furuta Y, Higashioka M, Oishi E, Kitazono T, Ninomiya T

    J Diabetes Investig   13   1677 - 1684   2022.10

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  • Day-to-day blood pressure variability and risk of incident chronic kidney disease in a general Japanese population Invited Reviewed International journal

    Sasaki T, Sakata S, Oishi E, Furuta Y, Honda T, Hata J, Tsuboi N, Kitazono T, Yokoo T, Ninomiya T

    J Am Heart Assoc   11   e027173   2022.10

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  • Active commuting, commuting modes and the risk of diabetes: 14-year follow-up data from the Hisayama study.

    Takanori Honda, Yoichiro Hirakawa, Jun Hata, Sanmei Chen, Mao Shibata, Satoko Sakata, Yoshihiko Furuta, Mayu Higashioka, Emi Oishi, Takanari Kitazono, Toshiharu Ninomiya

    Journal of diabetes investigation   13 ( 10 )   1677 - 1684   2022.10   ISSN:2040-1116 eISSN:2040-1124

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    AIMS/INTRODUCTION: We aimed to investigate the association of active commuting (cycling or walking to work), as well as the association of the individual commuting modes, with the risk of diabetes in a prospective cohort of community-dwelling adults in Japan. MATERIAL AND METHODS: A total of 1,270 residents aged 40-79 years were followed up for a median of 14 years. Active commuting was defined as either cycling or walking to work. A Cox proportional hazards model was used to examine the association of active commuting with the risk of diabetes. Associations for different forms of active commuting (cycling, walking and mixed modes of cycling or walking with non-active components) were also examined. RESULTS: During the follow-up period, 191 participants developed diabetes. Active commuting was associated with a lower risk of diabetes than non-active commuting after adjustment for potential confounders (hazard ratio [HR] 0.54, 95% confidence interval [CI] 0.31-0.92). With regard to the commuting modes, the risk of diabetes was significantly lower in individuals who commuted by cycling alone (HR 0.46, 95% CI 0.22-0.98), and tended to be lower in individuals who commuted by walking alone (HR 0.14, 95% CI 0.02-1.02) compared with that in individuals with non-active commuting. Meanwhile, no significant associations were observed for the mixed mode of walking and non-active commuting (HR 1.69, 95% CI 0.77-3.71). CONCLUSIONS: Active commuting, particularly that consisting exclusively of cycling or walking, was associated with a reduced risk of diabetes. Our findings support a public health policy that promotes the choice of active commuting for the prevention of diabetes.

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  • 活動的通勤および通勤形態と糖尿病リスクについて 久山町研究の14年間の追跡データ(Active commuting, commuting modes and the risk of diabetes: 14-year follow-up data from the Hisayama study)

    Honda Takanori, Hirakawa Yoichiro, Hata Jun, Chen Sanmei, Shibata Mao, Sakata Satoko, Furuta Yoshihiko, Higashioka Mayu, Oishi Emi, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Diabetes Investigation   13 ( 10 )   1677 - 1684   2022.10   ISSN:2040-1116

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    通勤手段の違いが糖尿病発症リスクに及ぼす影響について検討した。対象は福岡県久山町の住民検診を受診した40~79歳の住民1208名で、通勤手段に徒歩か自転車を含む活動的通勤者が189名、自動車や公共交通機関のみの非活動的通勤者が653名、非通勤者が366名であった。追跡期間中央値14年で191名が糖尿病を発症した。Cox比例ハザードモデルによる解析の結果、活動的通勤者は非活動的通勤者に比べて糖尿病発症リスクが有意に低かった(調整HR 0.54、95%CI 0.31~0.92、p=0.02)。通勤形態別にみた糖尿病発症のHR(95%CI)は、非活動的通勤者を基準として、自転車のみが0.46(0.22~0.98、p=0.04)、徒歩のみが0.14(0.02~1.02、p=0.053)であった。徒歩と非活動的通勤手段の併用は、糖尿病発症リスクの低下と関連しなかった(HR 1.69、95%CI 0.77~3.71)。

  • Altruistic Social Activity, Depressive Symptoms, and Brain Regional Gray Matter Volume: Voxel-Based Morphometry Analysis from 8695 Old Adults. International journal

    Yingxu Liu, Ye Zhang, Benjamin Thyreau, Yasuko Tatewaki, Izumi Matsudaira, Yuji Takano, Naoki Hirabayashi, YoshihikTo Furuta, Hata Jun, Toshiharu Ninomiya, Yasuyuki Taki

    The journals of gerontology. Series A, Biological sciences and medical sciences   77 ( 9 )   1789 - 1797   2022.9   ISSN:1079-5006 eISSN:1758-535X

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    Altruistic social activity, such as giving support to others, has shown protective benefits on dementia risk and cognitive decline. However, the pathological mechanism is unclear. In the present study, we investigated the association between altruistic social activity and brain regional gray matter. Furthermore, to explore the psychological interplay in altruistic social activity, we tested mediating effect of depressive symptoms on brain regional gray matter. We performed a cross-sectional Voxel-Based Morphology (VBM) analysis including 8695 old adults (72.9±6.1 years) from Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) Cohort. We measured altruistic social activities by self-report questionnaire, depressive symptoms by Geriatric Depression Scale (GDS)-short version. We employed the whole-brain VBM method to detect relevant structural properties related to altruistic social activity. We then performed multiple regression models to detect the mediating effect of depressive symptoms on particular brain regional gray matter volume while adjusting possible physical and social lifestyle covariables. We found that altruistic social activity is associated with larger gray matter volume in posterior insula, middle cingulate gyrus, hippocampus, thalamus, superior temporal gyrus, anterior orbital gyrus, and middle occipital gyrus. Depressive symptoms mediated over 10% on altruistic social activity and hippocampus volume, over 20% on altruistic social activity and cingulate gyrus volume. Our results indicated that altruistic social activity might preserve brain regional gray matter where are sensitive to aging and cognitive decline. Meanwhile, this association may be explained by indirect effect on depressive symptoms, suggesting that altruistic social activity may mitigate the neuropathology of dementia.

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  • Risks of Mortality and Airflow Limitation in Japanese with Preserved Ratio Impaired Spirometry. International journal

    Yasuyoshi Washio, Satoko Sakata, Satoru Fukuyama, Takanori Honda, Keiko Kan-O, Mao Shibata, Jun Hata, Hiromasa Inoue, Takanari Kitazono, Koichiro Matsumoto, Toshiharu Ninomiya

    American journal of respiratory and critical care medicine   206 ( 5 )   563 - 572   2022.9   ISSN:1073-449X eISSN:1535-4970

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    RATIONALE: Several Western studies have reported that participants with preserved ratio impaired spirometry (PRISm) have higher risks of airflow limitation (AFL) and death. However, evidence in East Asian populations is limited. OBJECTIVES: To investigate the relation between PRISm and the risks of death and incident AFL in a Japanese population. METHODS: A total of 3,032 community-dwelling Japanese participants aged ≥40 years were followed up for a median of 5.3 years by annual spirometry examinations. Participants were classified into lung function categories at baseline as follows: normal spirometry (forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) ≥0.70 and FEV1 ≥80% predicted), PRISm (≥0.70 and <80%), AFL Global Initiative for Chronic Obstructive Lung Disease (GOLD) 1 (<0.70 and ≥80%), and AFL GOLD 2-4 (<0.70 and <80%). Hazard ratios (HRs) and their 95% confidence intervals (CIs) were computed using a Cox proportional hazard model. MEASUREMENTS AND MAIN RESULTS: During the follow-up period, 131 participants died, 22 of whom died from cardiovascular disease, and 218 participants developed AFL. When examining the prognosis of each baseline pulmonary function category, participants with PRISm had higher risks of all-cause death (HR 2.20 [95%CI: 1.35 to 3.59]) and cardiovascular death (HR 4.07 [1.07 to 15.42]) than those with normal spirometry after adjusting for confounders. Moreover, the multivariable-adjusted risk of incident AFL was greater in participants with PRISm than in those with normal spirometry (HR 2.48 [1.83 to 3.36]). CONCLUSIONS: PRISm was associated with higher risks of all-cause and cardiovascular death and a greater risk of the development of AFL in a Japanese community. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • Altruistic social activity, depressive symptoms, and brain regional gray matter volume: voxel-based morphometry analysis from 8,695 old adults. Invited Reviewed International journal

    Liu Y, Zhang Y, Thyreau B, Tatewaki Y, Matsudaira I, Takano Y, Hirabayashi N, Furuta Y, Hata J, Ninomiya T, Taki Y; Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) Study Group

    J Gerontol A Biol Sci Med Sci   77   1789 - 1797   2022.9

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  • Risks of mortality and airflow limitation in Japanese individuals with preserved ratio impaired spirometry. Invited Reviewed International journal

    Washio Y, Sakata S, Fukuyama S, Honda T, Kan-o K, Shibata M, Hata J, Inoue H, Kitazono T, Matsumoto K, Ninomiya T

    Am J Respir Crit Care Med   206   563 - 572   2022.9

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  • Secular trends in the prevalence of dementia based on a community-based complete enumeration in Japan: the Nakayama Study. Invited Reviewed International journal

    Shimizu H, Mori T, Yoshida T, Tachibana A, Ozaki T, Yoshino Y, Ochi S, Sonobe N, Matsumoto T, Komori K, Iga JI, Ninomiya T, Ueno SI, Ikeda M

    Psychogeriatrics   22   631 - 641   2022.9

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  • Higher-resolution quantification of white matter hypointensities by large-scale transfer learning from 2D images on the JPSC-AD cohort. Invited Reviewed International journal

    Thyreau B, Tatewaki Y, Chen L, Takano Y, Hirabayashi N, Furuta Y, Hata J, Nakaji S, Maeda T, Noguchi-Shinohara M, Mimura M, Nakashima K, Mori T, Takebayashi M, Ninomiya T, Taki Y; Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) St

    Hum Brain Mapp   43   3998 - 4012   2022.9

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  • Higher-resolution quantification of white matter hypointensities by large-scale transfer learning from 2D images on the JPSC-AD cohort. International journal

    Benjamin Thyreau, Yasuko Tatewaki, Liying Chen, Yuji Takano, Naoki Hirabayashi, Yoshihiko Furuta, Jun Hata, Shigeyuki Nakaji, Tetsuya Maeda, Moeko Noguchi-Shinohara, Masaru Mimura, Kenji Nakashima, Takaaki Mori, Minoru Takebayashi, Toshiharu Ninomiya, Yasuyuki Taki

    Human brain mapping   43 ( 13 )   3998 - 4012   2022.9   ISSN:1065-9471 eISSN:1097-0193

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    White matter lesions (WML) commonly occur in older brains and are quantifiable on MRI, often used as a biomarker in Aging research. Although algorithms are regularly proposed that identify these lesions from T2-fluid-attenuated inversion recovery (FLAIR) sequences, none so far can estimate lesions directly from T1-weighted images with acceptable accuracy. Since 3D T1 is a polyvalent and higher-resolution sequence, it could be beneficial to obtain the distribution of WML directly from it. However a serious difficulty, both for algorithms and human, can be found in the ambiguities of brain signal intensity in T1 images. This manuscript shows that a cross-domain ConvNet (Convolutional Neural Network) approach can help solve this problem. Still, this is non-trivial, as it would appear to require a large and varied dataset (for robustness) labelled at the same high resolution (for spatial accuracy). Instead, our model was taught from two-dimensional FLAIR images with a loss function designed to handle the super-resolution need. And crucially, we leveraged a very large training set for this task, the recently assembled, multi-sites Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) cohort. We describe the two-step procedure that we followed to handle such a large number of imperfectly labeled samples. A large-scale accuracy evaluation conducted against FreeSurfer 7, and a further visual expert rating revealed that WML segmentation from our ConvNet was consistently better. Finally, we made a directly usable software program based on that trained ConvNet model, available at https://github.com/bthyreau/deep-T1-WMH.

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  • Secular trends in the prevalence of dementia based on a community-based complete enumeration in Japan: the Nakayama Study. International journal

    Hideaki Shimizu, Takaaki Mori, Taku Yoshida, Ayumi Tachibana, Tomoki Ozaki, Yuta Yoshino, Shinichiro Ochi, Naomi Sonobe, Teruhisa Matsumoto, Kenjiro Komori, Jun-Ichi Iga, Toshiharu Ninomiya, Shu-Ichi Ueno, Manabu Ikeda

    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society   22 ( 5 )   631 - 641   2022.9   ISSN:1346-3500 eISSN:1479-8301

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    BACKGROUND: The number of dementia patients is increasing worldwide, especially in Japan, which has the world's highest ageing population. The increase in the number of older people with dementia is a medical and socioeconomic problem that needs to be prevented, but the actual situation is still not fully understood. METHODS: Four cross-sectional studies on dementia were conducted in 1997, 2004, 2012, and 2016 for complete enumeration of all residents aged 65 years and older. We examined the secular trends in the prevalence of all-cause dementia, Alzheimer's disease (AD), vascular dementia (VaD), and other/unclassified dementia. RESULTS: The age-standardised prevalence of all-cause dementia significantly increased (4.5% in 1997, 5.7% in 2004, 5.3% in 2012, 9.5% in 2016; P for trend <0.05). Similar trends were observed for AD (1.7%, 3.0%, 2.5% and 4.9%, respectively; P for trend <0.05) and other/unclassified dementia (0.8%, 1.0%, 1.0% and 2.2%, respectively; P for trend <0.05), whereas no significant change in VaD was seen (2.1%, 1.8%, 1.8%, 2.4%, respectively; P for trend = 0.77). The crude prevalence of all-cause dementia and AD increased from 1997 to 2016 among participants aged 75-79 years and ≥85 years (all P for trend <0.05). Similar trends were observed for other/unclassified dementia among participants aged ≥80 years (all P for trend <0.05), but not in VaD. CONCLUSIONS: The prevalence of dementia has increased beyond the ageing of the population, suggesting that factors in addition to ageing are involved in the increase in the number of older people with dementia. To control the increase in the number of older people with dementia, elucidation of secular trends in the incidence, mortality, and prognosis of dementia as well as the factors that promote and protect against dementia, and development of preventive strategies are necessary.

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  • 日本における地域全数調査に基づく認知症有病率の経年変化 中山研究(Secular trends in the prevalence of dementia based on a community-based complete enumeration in Japan: the Nakayama Study)

    Shimizu Hideaki, Mori Takaaki, Yoshida Taku, Tachibana Ayumi, Ozaki Tomoki, Yoshino Yuta, Ochi Shinichiro, Sonobe Naomi, Matsumoto Teruhisa, Komori Kenjiro, Iga Jun-ichi, Ninomiya Toshiharu, Ueno Shu-ichi, Ikeda Manabu

    Psychogeriatrics   22 ( 5 )   631 - 641   2022.9   ISSN:1346-3500

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    日本人高齢者における認知症有病率の経時変化について検討した。愛媛県中山町の65歳以上の全住民を対象とした横断調査を1997年、2004年、2012年、2016年に実施した。認知症と診断された高齢者をアルツハイマー病(AD)、脳血管性認知症、その他/分類不能に分けた。その結果、全原因認知症の年齢標準化有病率は有意に上昇していた(1997年4.5%、2004年5.7%、2012年5.3%、2016年9.5%、P for trend<0.05)。AD、その他/分類不能でも有意な上昇が認められたが、脳血管性認知症では有意な変化は認められなかった。全原因認知症およびADの粗有病率は、1997~2016年に75~79歳および85歳以上で有意に上昇していた。80歳以上におけるその他/分類不能認知症でも有意な上昇が認められたが、脳血管性認知症では、いずれの年齢層においても有意な経年変化は認められなかった。以上から、認知症高齢者の増加の背景には高齢化以外の要因が関与していることが示唆された。

  • Association of the prefrailty with global brain atrophy and white matter lesions among cognitively unimpaired older adults: the Nakajima study. International journal

    Moeko Noguchi-Shinohara, Kenjiro Ono, Sohshi Yuki-Nozaki, Kazuo Iwasa, Masami Yokogawa, Kiyonobu Komai, Benjamin Thyreau, Yasuko Tatewaki, Yasuyuki Taki, Mao Shibata, Tomoyuki Ohara, Jun Hata, Toshiharu Ninomiya, Masahito Yamada

    Scientific reports   12 ( 1 )   12129 - 12129   2022.8   ISSN:2045-2322

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    Physical frailty has been associated with adverse outcomes such as dementia. However, the underlying structural brain abnormalities of physical frailty are unclear. We investigated the relationship between physical frailty and structural brain abnormalities in 670 cognitively unimpaired individuals (mean age 70.1 years). Total brain volume (TBV), hippocampal volume (HV), total white matter hypointensities volume (WMHV), and estimated total intracranial volume (eTIV) on the 3D T1-weighted images were automatically computed using FreeSurfer software. Participants were divided into two states of physical frailty (robust vs. prefrail) based on the revised Japanese version of the Cardiovascular Health Study criteria. The multivariable-adjusted mean values of the TBV-to-eTIV ratio was significantly decreased, whereas that of the WMHV-to-eTIV ratio was significantly increased in the prefrail group compared with the robust group. Slowness, one of the components of physical frailty, was significantly associated with reduced TBV-to-eTIV and HV-to-eTIV ratios, and slowness and weakness were significantly associated with an increased WMHV-to-eTIV ratio. Our results suggest that the prefrail state is significantly associated with global brain atrophy and white matter hypointensities. Furthermore, slowness was significantly associated with hippocampal atrophy.

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  • Association of the prefrailty with global brain atrophy and white matter lesions among cognitively unimpaired older adults: the Nakajima study. Invited Reviewed International journal

    Noguchi-Shinohara M, Ono K, Yuki-Nozaki S, Iwasa K, Yokogawa M, Komai K, Thyreau B, Tatewaki Y, Taki Y, Shibata M, Ohara T, Hata J, Ninomiya T, Yamada M

    Sci Rep   12   12129   2022.8

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  • Activation of Microglia and Impairment of Neurogenesis through DNA Repair Enzyme, MUTYH, in the Pathogenesis of Alzheimer's Disease

    Abolhassani, N; Mizuno, Y; Mazzei, G; Sakumi, K; Saito, T; Saido, TC; Ninomiya, T; Iwaki, T; Yamasaki, R; Kira, JI; Nakabeppu, Y

    ENVIRONMENTAL AND MOLECULAR MUTAGENESIS   63   79 - 79   2022.8   ISSN:0893-6692 eISSN:1098-2280

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  • Gefitinib induction followed by chemoradiotherapy in EGFR-mutant, locally advanced non-small-cell lung cancer: LOGIK0902/OLCSG0905 phase II study (vol 6, 100191, 2021)

    Hotta, K; Saeki, S; Yamaguchi, M; Harada, D; Bessho, A; Tanaka, K; Inoue, K; Gemba, K; Shiojiri, M; Kato, Y; Ninomiya, T; Kubo, T; Kishimoto, J; Shioyama, Y; Katsui, K; Sasaki, J; Kiura, K; Sugio, K

    ESMO OPEN   7 ( 4 )   100532   2022.8   eISSN:2059-7029

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    The authors regret that despite our best care and attention, we have discovered one error in text and corresponding errors in Table 3 and Supplementary Table S2. 1) One error, placed in the “Toxicity” paragraph in Results section has now been corrected as follows:“Radiation pneumonitis, the most clinically important toxicity, occurred in 14 (82%; grade 1) and 2 (12%; grade 2) patients; …”. 2) In Table 3, number and proportion of those with any grade radiation pneumonitis in CRT phase have also been corrected as “16 (94)”.3) Supplementary Table S2 has also been corrected, according to the former correction of number of patients who had pneumonitis events from 14 to 16.The authors would like to apologize for any inconvenience caused.

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  • Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community. Reviewed International journal

    Akane Mihara, Tomoyuki Ohara, Jun Hata, Sanmei Chen, Takanori Honda, Sonam Tamrakar, Akiko Isa, Dongmei Wang, Kuniyoshi Shimizu, Yoshinori Katakura, Koji Yonemoto, Tomohiro Nakao, Takanari Kitazono, Toshiharu Ninomiya

    Scientific reports   12 ( 1 )   12427 - 12427   2022.7   ISSN:2045-2322

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    We examined the association of serum s-adenosylmethionine (SAM), s-adenosylhomocysteine (SAH) (methionine metabolites), and their ratio on the risk of dementia and death in a community-dwelling population of older Japanese individuals. 1371 residents of Hisayama, Japan, aged 65 years or older and without dementia, were followed for a median of 10.2 years (2007-2017). We divided serum SAM, SAH, and SAM/SAH ratio into quartiles. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) of serum SAM, SAH, and SAM/SAH ratio levels on the risk of a composite outcome of all-cause dementia or death, and each outcome. During the follow-up, 635 participants developed all-cause dementia and/or died, of which 379 participants developed dementia and 394 deaths occurred. The multivariable-adjusted HRs of the composite outcome decreased significantly with increasing serum SAM levels (P for trend = 0.01), while they increased significantly with higher serum SAH levels (P for trend = 0.03). Higher serum SAM/SAH ratio levels were significantly associated with a lower risk of the composite outcome (P for trend = 0.002), as well as with lower risk of each outcome. Our findings suggest that the balance of methionine metabolites may closely associate with the risk of dementia and death.

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  • Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community. Invited Reviewed International journal

    Mihara A, Ohara T, Hata J, Chen S, Honda T, Tamrakar S, Isa A, Wang D, Shimizu K, Katakura Y, Yonemoto K, Nakao T, Kitazono T, Ninomiya T

    Sci Rep   12   12427   2022.7

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  • Association between diabetes and gray matter atrophy patterns in a general older Japanese population: the Hisayama Study. Invited Reviewed International journal

    Hirabayashi N, Hata J, Furuta Y, Ohara T, Shibata M, Hirakawa Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Ninomiya T

    Diabetes Care   45   1364 - 1371   2022.6

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  • Association Between Diabetes and Gray Matter Atrophy Patterns in a General Older Japanese Population: The Hisayama Study. International journal

    Naoki Hirabayashi, Jun Hata, Yoshihiko Furuta, Tomoyuki Ohara, Mao Shibata, Yoichiro Hirakawa, Fumio Yamashita, Kazufumi Yoshihara, Takanari Kitazono, Nobuyuki Sudo, Toshiharu Ninomiya

    Diabetes care   45 ( 6 )   1364 - 1371   2022.6   ISSN:0149-5992 eISSN:1935-5548

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    OBJECTIVE: To examine the association between diabetes and gray matter atrophy patterns in a general older Japanese population. RESEARCH DESIGN AND METHODS: In 2012, a total of 1,189 community-dwelling Japanese aged ≥65 years underwent brain MRI scans. Regional gray matter volumes (GMV) and intracranial volume (ICV) were measured by applying voxel-based morphometry (VBM) methods. The associations of diabetes and related parameters with the regional GMV/ICV were examined using an ANCOVA. The regional gray matter atrophy patterns in the subjects with diabetes or elevated fasting plasma glucose (FPG) or 2-h postload glucose (2hPG) levels were investigated using VBM. RESULTS: Subjects with diabetes had significantly lower mean values of GMV/ICV in the frontal lobe, temporal lobe, insula, deep gray matter structures, and cerebellum than subjects without diabetes after adjusting for potential confounders. A longer duration of diabetes was also significantly associated with lower mean values of GMV/ICV in these brain regions. The multivariable-adjusted mean values of the temporal, insular, and deep GMV/ICV decreased significantly with elevating 2hPG levels, whereas higher FPG levels were not significantly associated with GMV/ICV of any brain regions. In the VBM analysis, diabetes was associated with gray matter atrophy in the bilateral superior temporal gyri, right middle temporal gyrus, left inferior temporal gyrus, right middle frontal gyrus, bilateral thalami, right caudate, and right cerebellum. CONCLUSIONS: The current study suggests that a longer duration of diabetes and elevated 2hPG levels are significant risk factors for gray matter atrophy in various brain regions.

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  • Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations

    Gerard Temprano‐Sagrera, Colleen M. Sitlani, William P. Bone, Miguel Martin‐Bornez, Benjamin F. Voight, Alanna C. Morrison, Scott M. Damrauer, Paul S. de Vries, Nicholas L. Smith, Maria Sabater‐Lleal, Abbas Dehghan, Adam S Heath, Alanna C Morrison, Alex P Reiner, Andrew Johnson, Anne Richmond, Annette Peters, Astrid van Hylckama Vlieg, Barbara McKnight, Bruce M Psaty, Caroline Hayward, Cavin Ward‐Caviness, Christopher O’Donnell, Daniel Chasman, David P Strachan, David A Tregouet, Dennis Mook‐Kanamori, Dipender Gill, Florian Thibord, Folkert W Asselbergs, Frank W.G. Leebeek, Frits R Rosendaal, Gail Davies, Georg Homuth, Gerard Temprano, Harry Campbell, Herman A Taylor, Jan Bressler, Jennifer E Huffman, Jerome I Rotter, Jie Yao, James F Wilson, Joshua C Bis, Julie M Hahn, Karl C Desch, Kerri L Wiggins, Laura M Raffield, Lawrence F Bielak, Lisa R Yanek, Marcus E Kleber, Maria Sabater‐Lleal, Martina Mueller, Maryam Kavousi, Massimo Mangino, Melissa Liu, Michael R Brown, Matthew P Conomos, Min‐A Jhun, Ming‐Huei Chen, Moniek P.M. de Maat, Nathan Pankratz, Nicholas L Smith, Patricia A Peyser, Paul Elliot, Paul S de Vries, Peng Wei, Philipp S Wild, Pierre E Morange, Pim van der Harst, Qiong Yang, Ngoc‐Quynh Le, Riccardo Marioni, Ruifang Li, Scott M Damrauer, Simon R Cox, Stella Trompet, Stephan B Felix, Uwe Völker, Weihong Tang, Wolfgang Koenig, J. Wouter Jukema, Xiuqing Guo, Sara Lindstrom, Lu Wang, Erin N Smith, William Gordon, Astrid van Hylckama Vlieg, Mariza de Andrade, Jennifer A Brody, Jack W Pattee, Jeffrey Haessler, Ben M Brumpton, Daniel I Chasman, Pierre Suchon, Ming‐Huei Chen, Constance Turman, Marine Germain, Kerri L Wiggins, James MacDonald, Sigrid K Braekkan, Sebastian M Armasu, Nathan Pankratz, Rabecca D Jackson, Jonas B Nielsen, Franco Giulianini, Marja K Puurunen, Manal Ibrahim, Susan R Heckbert, Theo K Bammler, Kelly A Frazer, Bryan M McCauley, Kent Taylor, James S Pankow, Alexander P Reiner, Maiken E Gabrielsen, Jean‐François Deleuze, Chris J O’Donnell, Jihye Kim, Barbara McKnight, Peter Kraft, John‐Bjarne Hansen, Frits R Rosendaal, John A Heit, Bruce M Psaty, Weihong Tang, Charles Kooperberg, Kristian Hveem, Paul M Ridker, Pierre‐Emmanuel Morange, Andrew D Johnson, Christopher Kabrhel, David‐Alexandre Trégouët, Nicholas L Smith, Rainer Malik, Ganesh Chauhan, Matthew Traylor, Muralidharan Sargurupremraj, Yukinori Okada, Aniket Mishra, Loes Rutten‐Jacobs, Anne‐Katrin Giese, Sander W van der Laan, Solveig Gretarsdottir, Christopher D Anderson, Michael Chong, Hieab HH Adams, Tetsuro Ago, Peter Almgren, Philippe Amouyel, Hakan Ay, Traci M Bartz, Oscar R Benavente, Steve Bevan, Giorgio B Boncoraglio, Robert D Brown, Adam S Butterworth, Caty Carrera, Cara L Carty, Daniel I Chasman, Wei‐Min Chen, John W Cole, Adolfo Correa, Ioana Cotlarciuc, Carlos Cruchaga, John Danesh, Paul IW de Bakker, Anita L DeStefano, Marcel den Hoed, Qing Duan, Stefan T Engelter, Guido J Falcone, Rebecca F Gottesman, Raji P Grewal, Vilmundur Gudnason, Stefan Gustafsson, Jeffrey Haessler, Tamara B Harris, Ahamad Hassan, Aki S Havulinna, Susan R Heckbert, Elizabeth G Holliday, George Howard, Fang‐Chi Hsu, Hyacinth I Hyacinth, M Arfan Ikram, Erik Ingelsson, Marguerite R Irvin, Xueqiu Jian, Jordi Jiménez‐Conde, Julie A Johnson, J Wouter Jukema, Masahiro Kanai, Keith L Keene, Brett M Kissela, Dawn O Kleindorfer, Charles Kooperberg, Michiaki Kubo, Leslie A Lange, Carl D Langefeld, Claudia Langenberg, Lenore J Launer, Jin‐Moo Lee, Robin Lemmens, Didier Leys, Cathryn M Lewis, Wei‐Yu Lin, Arne G Lindgren, Erik Lorentzen, Patrik K Magnusson, Jane Maguire, Ani Manichaikul, Patrick F McArdle, James F Meschia, Braxton D Mitchell, Thomas H Mosley, Michael A Nalls, Toshiharu Ninomiya, Martin J O’Donnell, Bruce M Psaty, Sara L Pulit, Kristiina Rannikmäe, Alexander P Reiner, Kathryn M Rexrode, Kenneth Rice, Stephen S Rich, Paul M Ridker, Natalia S Rost, Peter M Rothwell, Jerome I Rotter, Tatjana Rundek, Ralph L Sacco, Saori Sakaue, Michele M Sale, Veikko Salomaa, Bishwa R Sapkota, Reinhold Schmidt, Carsten O Schmidt, Ulf Schminke, Pankaj Sharma, Agnieszka Slowik, Cathie LM Sudlow, Christian Tanislav, Turgut Tatlisumak, Kent D Taylor, Vincent NS Thijs, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Steffen Tiedt, Stella Trompet, Christophe Tzourio, Cornelia M van Duijn, Matthew Walters, Nicholas J Wareham, Sylvia Wassertheil‐Smoller, James G Wilson, Kerri L Wiggins, Qiong Yang, Salim Yusuf, Najaf Amin, Hugo S Aparicio, Donna K Arnett, John Attia, Alexa S Beiser, Claudine Berr, Julie E Buring, Mariana Bustamante, Valeria Caso, Yu‐Ching Cheng, Seung Hoan Choi, Ayesha Chowhan, Natalia Cullell, Jean‐François Dartigues, Hossein Delavaran, Pilar Delgado, Marcus Dörr, Gunnar Engström, Ian Ford, Wander S Gurpreet, Anders Hamsten, Laura Heitsch, Atsushi Hozawa, Laura Ibanez, Andreea Ilinca, Martin Ingelsson, Motoki Iwasaki, Rebecca D Jackson, Katarina Jood, Pekka Jousilahti, Sara Kaffashian, Lalit Kalra, Masahiro Kamouchi, Takanari Kitazono, Olafur Kjartansson, Manja Kloss, Peter J Koudstaal, Jerzy Krupinski, Daniel L Labovitz, Cathy C Laurie, Christopher R Levi, Linxin Li, Lars Lind, Cecilia M Lindgren, Vasileios Lioutas, Yong Mei Liu, Oscar L Lopez, Hirata Makoto, Nicolas Martinez‐Majander, Koichi Matsuda, Naoko Minegishi, Joan Montaner, Andrew P Morris, Elena Muiño, Martina Müller‐Nurasyid, Bo Norrving, Soichi Ogishima, Eugenio A Parati, Leema Reddy Peddareddygari, Nancy L Pedersen, Joanna Pera, Markus Perola, Alessandro Pezzini, Silvana Pileggi, Raquel Rabionet, Iolanda Riba‐Llena, Marta Ribasés, Jose R Romero, Jaume Roquer, Anthony G Rudd, Antti‐Pekka Sarin, Ralhan Sarju, Chloe Sarnowski, Makoto Sasaki, Claudia L Satizabal, Mamoru Satoh, Naveed Sattar, Norie Sawada, Gerli Sibolt, Ásgeir Sigurdsson, Albert Smith, Kenji Sobue, Carolina Soriano‐Tárraga, Tara Stanne, O Colin Stine, David J Stott, Konstantin Strauch, Takako Takai, Hideo Tanaka, Kozo Tanno, Alexander Teumer, Liisa Tomppo, Nuria P Torres‐Aguila, Emmanuel Touze, Shoichiro Tsugane, Andre G Uitterlinden, Einar M Valdimarsson, Sven J van der Lee, Henry Völzke, Kenji Wakai, David Weir, Stephen R Williams, Charles DA Wolfe, Quenna Wong, Huichun Xu, Taiki Yamaji, Dharambir K Sanghera, Olle Melander, Christina Jern, Daniel Strbian, Israel Fernandez‐Cadenas, W T Longstreth, Arndt Rolfs, Jun Hata, Daniel Woo, Jonathan Rosand, Guillaume Pare, Jemma C Hopewell, Danish Saleheen, Kari Stefansson, Bradford B Worrall, Steven J Kittner, Sudha Seshadri, Myriam Fornage, Hugh S Markus, Joanna MM Howson, Yoichiro Kamatani, Stephanie Debette, Martin Dichgans

    Journal of Thrombosis and Haemostasis   20 ( 6 )   1331 - 1349   2022.6   ISSN:1538-7836

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  • Association of Inner Retinal Thickness with Prevalent Dementia and Brain Atrophy in a General Older Population: The Hisayama Study. International journal

    Emi Ueda, Naoki Hirabayashi, Tomoyuki Ohara, Jun Hata, Takanori Honda, Kohta Fujiwara, Yoshihiko Furuta, Mao Shibata, Sawako Hashimoto, Shun Nakamura, Taro Nakazawa, Tomohiro Nakao, Takanari Kitazono, Toshiharu Ninomiya, Koh-Hei Sonoda

    Ophthalmology science   2 ( 2 )   100157 - 100157   2022.6   ISSN:2666-9145

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    PURPOSE: To assess the association of inner retinal thickness with prevalent dementia and regional brain atrophy in a general older population of Japanese. DESIGN: Population-based, cross-sectional study. PARTICIPANTS: A total of 1078 residents aged 65 years or older who participated in an eye examination, a comprehensive survey of dementia, and brain magnetic resonance imaging scanning in 2017. METHODS: The thicknesses of the inner retinal layers, namely, the ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL)-were measured by swept-source OCT (SS-OCT). The association of these retinal thicknesses with the risk of the presence of dementia was estimated using restricted cubic splines and logistic regression models. Regional brain volumes were estimated separately by applying 2 different methods: voxel-based morphometry (VBM) and analysis by FreeSurfer software. The associations of GC-IPL and RNFL thickness with each brain regional volume were analyzed using multiple regression analysis. MAIN OUTCOME MEASURE: Prevalent dementia and regional brain atrophy. RESULTS: Among the study participants, 61 participants (5.7%) were diagnosed with dementia. The likelihood of the presence of dementia significantly increased with lower GC-IPL thickness after adjusting for potential confounders (odds ratio, 1.62 [95% confidence interval, 1.30-2.01] per 1 standard deviation decrement in the GC-IPL thickness), but no significant association was observed with RNFL thickness. In the VBM analyses with the multivariable adjustment, lower GC-IPL thickness was significantly associated with lower volume of known brain regions related to cognitive functions (i.e., the hippocampus, amygdala, entorhinal area, and parahippocampal gyrus) and visual functions (i.e., the cuneus, lingual gyrus, and thalamus). Meanwhile, the volume of the thalamus significantly decreased with lower RNFL thickness, but none of the brain regions related to cognitive function exhibited a volume change in association with RNFL thickness. The sensitivity analysis using FreeSurfer analysis also showed that lower GC-IPL thickness was significantly associated with lower regional brain volume/intracranial volume of the hippocampus, amygdala, cuneus, lingual gyrus, and thalamus. CONCLUSIONS: Our findings suggest that the measurement of GC-IPL thickness by SS-OCT, which is a noninvasive, convenient, and reproducible method, might be useful for identifying high-risk individuals with dementia.

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  • 特集 予防医学からみた腎疾患診療 【CKDの発症・進展と合併症のリスクとされるエビデンス】 肥満 肥満と腎障害の疫学研究

    佐々木 峻也, 二宮 利治

    腎と透析   92 ( 5 )   833 - 837   2022.5   ISSN:03852156

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  • Association of inner retinal thickness with prevalent dementia and brain atrophy in a general older population: the Hisayama Study. Invited Reviewed International journal

    Ueda E, Hirabayashi N, Ohara T, Hata J, Honda T, Fujiwara K, Furuta Y, Shibata M, Hashimoto S, Nakamura S, Nakazawa T, Nakao T, Kitazono T, Ninomiya T, Sonoda KH

    Ophthalmol Sci   100157   2022.4

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  • Baseline periodontal status and modifiable risk factors are associated with tooth loss over a 10-year period: Estimates of population attributable risk in a Japanese community. Invited Reviewed International journal

    Furuta M, Takeuchi K, Takeshita T, Shibata Y, Suma S, Kageyama S, Asakawa M, Shimazaki Y, Hata J, Ninomiya T, Yamashita Y

    J Periodontol   93   526 - 536   2022.4

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  • Association of daily sleep duration with the incident dementia by serum soluble TREM2 in a community. Invited Reviewed International journal

    Ohara T, Hata J, Tanaka M, Honda T, Yamakage H, Inoue T, Hirakawa Y, Kusakabe T, Shibata M, Kitazono T, Nakao T, Satoh-Asahara N, Ninomiya T

    J Am Geriatr Soc   70   1147 - 1156   2022.4

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  • Yogurt product intake and reduction of tooth loss risk in a Japanese community. Invited Reviewed International journal

    Ma J, Furuta M, Uchida K, Takeshita T, Kageyama S, Asakawa M, Takeuchi K, Suma S, Sakata S, Hata J, Sohn W, Ninomiya T, Yamashita Y

    J Clin Periodontol   49   345 - 352   2022.4

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  • Baseline periodontal status and modifiable risk factors are associated with tooth loss over a 10-year period: Estimates of population attributable risk in a Japanese community

    Furuta, M; Takeuchi, K; Takeshita, T; Shibata, Y; Suma, S; Kageyama, S; Asakawa, M; Shimazaki, Y; Hata, J; Ninomiya, T; Yamashita, Y

    JOURNAL OF PERIODONTOLOGY   93 ( 4 )   526 - 536   2022.4   ISSN:0022-3492 eISSN:1943-3670

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    Background: This study aimed to examine whether modifiable risk factors can predict tooth loss over 10 years and estimate population attributable risk (PAR) for a combination of modifiable factors. Methods: This longitudinal study included 1466 participants who underwent dental examinations in 2007 and 2017 and were aged 40 to 79 years at baseline. Periodontal conditions were assessed using the 2018 periodontal classification. Incident tooth loss was defined as ≥4 teeth lost over a 10-year period. We calculated the partial PAR (pPAR%) for tooth loss to estimate the combined effect of modifiable risk factors. Results: Incidence of tooth loss was 17.5%. Directed acyclic graphs were used to identify risk factors for tooth loss. A logistic regression model showed that baseline periodontitis, dental caries experience, no regular dental visit, periodontal treatment, smoking, and obesity were associated with tooth loss after adjusting for covariates; pPAR% was 55.5% (95% confidence interval: 31.1% to 73.0%) in periodontitis Stage III to IV and 87.6% (50.4% to 97.4%) in the combination of all factors, respectively. The sex-stratified analysis showed that smoking and no regular dental visit in men and obesity in women were identified as potential risk factors for tooth loss. Conclusions: Modifiable factors accounted for most cases of incident tooth loss. Risk factors for tooth loss might differ by sex, suggesting that the appropriate approach for preventing tooth loss base on sex.

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  • Association of daily sleep duration with the incident dementia by serum soluble TREM2 in a community. International journal

    Tomoyuki Ohara, Jun Hata, Masashi Tanaka, Takanori Honda, Hajime Yamakage, Takayuki Inoue, Yoichiro Hirakawa, Toru Kusakabe, Mao Shibata, Takanari Kitazono, Tomohiro Nakao, Noriko Satoh-Asahara, Toshiharu Ninomiya

    Journal of the American Geriatrics Society   70 ( 4 )   1147 - 1156   2022.4   ISSN:0002-8614 eISSN:1532-5415

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    BACKGROUND: Little is known about the influence of serum level of soluble triggering receptor expressed on myeloid cells 2 (sTREM2), which is a soluble type of an innate immune receptor expressed on the microglia, on the association of the daily sleep duration with the risk of dementia. METHODS: A total of 1230 Japanese community-residents aged 60 and older without dementia were followed prospectively for 10 years (2002-2012). Serum sTREM2 levels were divided into two groups using the median value (334.8 pg/ml). Self-reported daily sleep duration was grouped into three categories of <5.0, 5.0-7.9, and ≥8.0 h. A Cox proportional hazards model was used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) of daily sleep duration on the risk of dementia according to serum sTREM2 levels. RESULTS: During the follow-up, 262 subjects developed dementia. In subjects with low serum sTREM2 levels, subjects with ≥8.0 h of daily sleep had a significantly greater risk of dementia (multivariable-adjusted HR 2.05 [95% CI 1.32-3.19]) than those with 5.0-7.9 h of daily sleep, but those with <5.0 h did not. In contrast, the risk of dementia increased significantly in subjects with both <5.0 (1.95 [1.03-3.68]) and ≥8.0 h of daily sleep (1.48 [1.06-2.07]) in the subjects with high serum sTREM2 levels. CONCLUSIONS: The influence of daily sleep duration on risk of dementia differed according to serum sTREM2 levels in the older Japanese population. Short daily sleep may be associated with greater risk of dementia only in subjects with a high serum sTREM2 level.

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  • Yogurt product intake and reduction of tooth loss risk in a Japanese community. International journal

    Jiale Ma, Michiko Furuta, Kazuhiro Uchida, Toru Takeshita, Shinya Kageyama, Mikari Asakawa, Kenji Takeuchi, Shino Suma, Satoko Sakata, Jun Hata, Woosung Sohn, Toshiharu Ninomiya, Yoshihisa Yamashita

    Journal of clinical periodontology   49 ( 4 )   345 - 352   2022.4   ISSN:0303-6979 eISSN:1600-051X

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    AIM: To evaluate the longitudinal association between yogurt product intake and oral health in a population-based study. MATERIALS AND METHODS: This study included 1967 Japanese residents aged 40-79 years who underwent dental examinations in 2012. Among them, 1469 participants were followed up in 2017 for the incidence of tooth loss, which was defined as two or more teeth lost over 5 years. The intake of yogurt products, defined as yogurt and lactic acid beverages, was estimated using a semi-quantitative food frequency questionnaire. The composition of the salivary microbiota was evaluated. RESULTS: The Poisson regression model showed that a higher intake of yogurt products was negatively associated with the incidence of tooth loss (p for trend = .020), adjusted for potential confounding factors. Mediation analysis confirmed that periodontal condition partly mediated the effect of yogurt product intake on tooth loss, while dental caries experience did not. Additionally, we confirmed the association of a high intake of yogurt products with a low percentage of the salivary microbiota pattern, which was associated with poor oral health. CONCLUSION: These findings suggest that the intake of yogurt products is associated with a lower risk of tooth loss resulting from periodontal disease, probably via modulation of the oral microbiome composition.

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  • Long-term association of vegetable and fruit intake with risk of dementia in Japanese older adults: the Hisayama study. International journal

    Yasumi Kimura, Daigo Yoshida, Tomoyuki Ohara, Jun Hata, Takanori Honda, Yoichiro Hirakawa, Mao Shibata, Emi Oishi, Satoko Sakata, Yoshihiko Furuta, Sanmei Chen, Kazuhiro Uchida, Tomohiro Nakao, Takanari Kitazono, Toshiharu Ninomiya

    BMC geriatrics   22 ( 1 )   257 - 257   2022.3   eISSN:1471-2318

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    BACKGROUND: Several prospective Western studies have reported an inverse association of vegetable and fruit intake with dementia risk. However, there is limited epidemiologic evidence in Asians. This study investigated the association of intakes of vegetables, fruits, and their nutrients on the risk of incident dementia and its subtypes in a Japanese community. METHODS: A total of 1071 participants (452 men and 619 women) aged ≥60 years without dementia at baseline were prospectively followed up for 24 years. Intakes of vegetables, fruits, and nutrients were evaluated using a 70-item semiquantitative food frequency questionnaire at baseline and were categorized into quartiles separately by gender. The outcome measure was the development of dementia and its subtypes-namely, Alzheimer's disease (AD) and vascular dementia (VaD). The risk estimates of incident dementia were computed using a Cox proportional hazards model. RESULTS: During the long-term follow-up period, 464 subjects developed dementia, of whom 286 had AD and 144 had VaD. Higher vegetable intake was associated gradually with lower risk of developing dementia and AD (both P-trend < 0.05), but not VaD, after adjusting for confounders. Subjects allocated the highest quartile of vegetable intake had 27 and 31% lower risk of dementia and AD, respectively, than those with the lowest quartile. The risk of dementia decreased significantly with higher intakes of vitamin A, riboflavin, vitamin C, magnesium, calcium, and potassium (all P-trend < 0.05). Subjects with higher total dietary fiber intake tended to be at decreased risk for total dementia (P-trend = 0.07). Meanwhile, there were no significant associations between fruit intake and the risk of dementia and its subtypes. CONCLUSION: Higher intakes of vegetables and their constituent nutrients were associated with a lower risk of dementia in Japanese older adults. A diet rich in vegetables may be beneficial in reducing the dementia risk in Asians.

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  • Development and Validation of a Risk Prediction Model for Atherosclerotic Cardiovascular Disease in Japanese Adults: The Hisayama Study

    Honda Takanori, Chen Sanmei, Hata Jun, Yoshida Daigo, Hirakawa Yoichiro, Furuta Yoshihiko, Shibata Mao, Sakata Satoko, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   29 ( 3 )   345 - 361   2022.3   ISSN:13403478 eISSN:18803873

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    <p><b>Aim:</b>To develop and validate a new risk prediction model for predicting the 10-year risk of atherosclerotic cardiovascular disease (ASCVD) in Japanese adults. </p><p><b>Methods:</b> A total of 2,454 participants aged 40–84 years without a history of cardiovascular disease (CVD) were prospectively followed up for 24 years. An incident ASCVD event was defined as the first occurrence of coronary heart disease or atherothrombotic brain infarction. A Cox proportional hazards regression model was used to construct the prediction model. In addition, a simplified scoring system was translated from the developed prediction model. The model performance was evaluated using Harrell’s C statistics, a calibration plot with the Greenwood-Nam-D’Agostino test, and a bootstrap validation procedure. </p><p><b>Results:</b> During a median of a 24-year follow-up, 270 participants experienced the first ASCVD event. The predictors of the ASCVD events in the multivariable Cox model included age, sex, systolic blood pressure, diabetes, serum high-density lipoprotein cholesterol, serum low-density lipoprotein cholesterol, proteinuria, smoking habits, and regular exercise. The developed models exhibited good discrimination with negligible evidence of overfitting (Harrell’s C statistics: 0.786 for the multivariable model and 0.789 for the simplified score) and good calibrations (the Greenwood-Nam-D’Agostino test: <i>P</i>=0.29 for the multivariable model, 0.52 for the simplified score). </p><p><b>Conclusion:</b> We constructed a risk prediction model for the development of ASCVD in Japanese adults. This prediction model exhibits great potential as a tool for predicting the risk of ASCVD in clinical practice by enabling the identification of specific risk factors for ASCVD in individual patients. </p>

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  • Development and validation of a risk prediction model for atherosclerotic cardiovascular disease in Japanese adults: the Hisayama Study Invited Reviewed International journal

    Honda T, Chen S, Hata J, Yoshida D, Hirakawa Y, Furuta Y, Shibata M, Sakata S, Kitazono T, Ninomiya T

    J Atheroscler Thromb   29   345 - 361   2022.3

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  • Long-term association of vegetable and fruit intake with risk of dementia in Japanese older adults: the Hisayama Study. Invited Reviewed International journal

    Kimura Y, Yoshida D, Ohara T, Hata J, Honda T, Hirakawa Y, Shibata M, Oishi E, Sakata S, Furuta Y, Chen S, Uchida K, Nakao T, Kitazono T, Ninomiya T

    BMC Geriatr   22   257 - 257   2022.3

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  • Multiple-region grey matter atrophy as a predictor for the development of dementia in a community: the Hisayama Study. Invited Reviewed International journal

    Nakazawa T, Ohara T, Hirabayashi N, Furuta Y, Hata J, Shibata M, Honda T, Kitazono T, Nakao T, Ninomiya T

    J Neurol Neurosurg Psychiatry 93: 263-271, 2022   93   263 - 271   2022.3

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  • Response to "Letter Regarding Normal Albuminuria in Patients With Autopsy-Proven Advanced Diabetic Nephropathy"

    Sasaki, T; Ninomiya, T

    KIDNEY INTERNATIONAL REPORTS   7 ( 3 )   662 - 663   2022.3   ISSN:2468-0249

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  • Multiple-region grey matter atrophy as a predictor for the development of dementia in a community: the Hisayama Study. International journal

    Taro Nakazawa, Tomoyuki Ohara, Naoki Hirabayashi, Yoshihiko Furuta, Jun Hata, Mao Shibata, Takanori Honda, Takanari Kitazono, Tomohiro Nakao, Toshiharu Ninomiya

    Journal of neurology, neurosurgery, and psychiatry   93 ( 3 )   263 - 271   2022.3   ISSN:0022-3050 eISSN:1468-330X

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    OBJECTIVE: To assess the association of regional grey matter atrophy with dementia risk in a general older Japanese population. METHODS: We followed 1158 dementia-free Japanese residents aged ≥65 years for 5.0 years. Regional grey matter volume (GMV) at baseline was estimated by applying voxel-based morphometry methods. The GMV-to-total brain volume ratio (GMV/TBV) was calculated, and its association with dementia risk was estimated using Cox proportional hazard models. We assessed whether the predictive ability of a model based on known dementia risk factors could be improved by adding the total number of regions with grey matter atrophy among dementia-related brain regions, where the cut-off value for grey matter atrophy in each region was determined by receiver operating characteristic curves. RESULTS: During the follow-up, 113 participants developed all-cause dementia, including 83 with Alzheimer's disease (AD). Lower GMV/TBV of the medial temporal lobe, insula, hippocampus and amygdala were significantly/marginally associated with higher risk of all-cause dementia and AD (all p for trend ≤0.08). The risks of all-cause dementia and AD increased significantly with increasing total number of brain regions exhibiting grey matter atrophy (both p for trend <0.01). Adding the total number of regions with grey matter atrophy into a model consisting of known risk factors significantly improved the predictive ability for AD (Harrell's c-statistics: 0.765-0.802; p=0.02). CONCLUSIONS: Our findings suggest that the total number of regions with grey matter atrophy among the medial temporal lobe, insula, hippocampus and amygdala is a significant predictor for developing dementia, especially AD, in the general older population.

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  • 日本人成人における動脈硬化性心血管疾患リスクの予測モデルの開発および検証 久山町研究(Development and Validation of a Risk Prediction Model for Atherosclerotic Cardiovascular Disease in Japanese Adults: The Hisayama Study)

    Honda Takanori, Chen Sanmei, Hata Jun, Yoshida Daigo, Hirakawa Yoichiro, Furuta Yoshihiko, Shibata Mao, Sakata Satoko, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   29 ( 3 )   345 - 361   2022.3   ISSN:1340-3478

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    心血管疾患の既往がない成人被験者2454名(男性1026名、女性1428名、平均58.2±11.1歳)を対象に、Cox比例ハザードモデルを用いてアテローム動脈硬化性心血管疾患(ASCVD)発症のリスク予測モデルを開発し、妥当性を検証した。対象は久山町研究に参加した40歳から84歳までの一般住民で、ASCVDは冠状動脈性心疾患またはアテローム血栓性脳梗塞と定義した。平均追跡期間は24年で、ASCVDは270名で初発した。発生率は1000人あたり5.8人年であった。リスク予測モデルの予測因子として年齢、性別、収縮期血圧、糖尿病、血中HDLコレステロール、LDLコレステロール、蛋白尿、喫煙習慣、定期的な運動を選択した。上記の変数を組み込んで10年後のASCVD発症予測モデルを構築し、簡便なリスクスコアを作成した。C統計量により妥当性を評価したところ、ASCVD発症リスク予測モデル(0.786)と簡便なリスクスコア(0.789)のいずれも優れた識別能を呈した。またGreenwood-Nam-D' Agostino検定で良好なキャリブレーションが確認された(それぞれP=0.29とP=0.52)。

  • Changes in Body Weight and Concurrent Changes in Cardiovascular Risk Profiles in Community Residents in Japan: the Hisayama Study

    Honda Takanori, Ishida Yuki, Oda Masaaki, Noguchi Kenichi, Chen Sanmei, Sakata Satoko, Oishi Emi, Furuta Yoshihiko, Yoshida Daigo, Hirakawa Yoichiro, Hata Jun, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   29 ( 2 )   252 - 267   2022.2   ISSN:13403478 eISSN:18803873

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    <p><b>Aim:</b> We investigated the influence of weight change on concurrent changes in predicted cardiovascular disease (CVD) risk and individual CVD risk factors over time. </p><p><b>Methods:</b> A total of 2,140 community-dwellers aged 40–74 years participated in both 2002 and 2007 health examinations. Obesity was defined as body mass index ≥ 25 kg/m<sup>2</sup>. Weight trajectories were classified as: “stable obese” (obese at both examinations), “obese to nonobese” (obese in 2002 but nonobese in 2007), “nonobese to obese” (nonobese in 2002 but obese in 2007), or “stable nonobese” (nonobese at both examinations). We compared changes in the model-predicted risk for CVD and individual CVD risk factors across weight-change categories. </p><p><b>Results:</b> The predicted risk for CVD increased during 5 years in all groups; the increment in the predicted risk for CVD was smallest in the obese to nonobese participants and steepest in the nonobese to obese subjects. Compared with the stable obese participants, the obese to nonobese participants had greater favorable changes in waist circumferences, blood pressure, fasting plasma glucose, serum high-density lipoprotein cholesterol, serum triglycerides, and liver enzymes. For all these parameters, opposite trends were observed when comparing the nonobese to obese participants with the stable nonobese group. </p><p><b>Conclusions:</b> We demonstrated the favorable association of losing weight in obese people and avoiding excessive weight gain in nonobese people with global risk of future CVD and individual CVD risk factors in a real-world setting. The findings could improve behavioral lifestyle interventions that provide information on the health consequences of weight change at health checkups. </p>

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  • Serum uric acid levels and nephrosclerosis in a population-based autopsy study: the Hisayama Study. Invited Reviewed International journal

    Maki K, Hata J, Sakata S, Oishi E, Furuta Y, Nakano T, Oda Y, Kitazono T, Ninomiya T

    Am J Nephrol   53   69 - 77   2022.2

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  • Changes in body weight and concurrent changes in cardiovascular risk profiles in community residents in Japan: the Hisayama Study. Invited Reviewed International journal

    Honda T, Ishida Y, Oda M, Noguchi K, Chen S, Sakata S, Oishi E, Furuta Y, Yoshida D, Hirakawa Y, Hata J, Kitazono T, Ninomiya T

    J Atheroscler Thromb   29   252 - 267   2022.2

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  • Diabetes mellitus, elevated hemoglobin A1c, and glycated albumin are associated with the presence of all-cause dementia and alzheimer's disease: the JPSC-AD Study. Invited Reviewed International journal

    Noguchi-Shinohara M, Yuki-Nozaki S, Abe C, Mori A, Horimoto M, Yokogawa M, Ishida N, Suga Y, Ishizaki J, Ishimiya M, Nakamura H, Komai K, Nakamura H, Shibata M, Ohara T, Hata J, Ninomiya T, Yamada M; Japan Prospective Studies Collaboration for Aging and D

    J Alzheimers Dis   85   235 - 247   2022.2

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  • Serum Uric Acid Levels and Nephrosclerosis in a Population-Based Autopsy Study: The Hisayama Study. International journal

    Kenji Maki, Jun Hata, Satoko Sakata, Emi Oishi, Yoshihiko Furuta, Toshiaki Nakano, Yoshinao Oda, Takanari Kitazono, Toshiharu Ninomiya

    American journal of nephrology   53 ( 1 )   69 - 77   2022.2   ISSN:0250-8095 eISSN:1421-9670

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    INTRODUCTION: Information regarding the influence of serum uric acid (SUA) levels on pathological changes in the kidney is limited. In this study, we examined the association between SUA levels and pathological findings of nephrosclerosis in population-based autopsy samples. METHODS: A total of 923 deceased individuals in a Japanese community underwent autopsy examinations between 1974 and 1994. Of these, 547 individuals with available kidney tissues and health examination data within a median of 3 years before death were eligible for the present study. SUA levels were categorized into quintiles (Q1, 107-237; Q2, 238-279; Q3, 280-326; Q4, 327-380; Q5, 381-755 μmol/L). Advanced degrees of glomerular sclerosis, kidney arteriolar hyalinosis, and kidney arteriosclerosis were defined as the 90th percentile or more of a glomerular sclerosis index and an arteriolar hyalinosis index, and the 10th percentile or less of a wall-lumen ratio, respectively. A logistic regression model was used to evaluate odds ratios (ORs) and their 95% confidence intervals (CIs) of SUA levels on each kidney lesion. RESULTS: Higher SUA levels were significantly associated with higher values of the age- and sex-adjusted glomerular sclerosis index and lower values of the wall-lumen ratio (both p for trend <0.01). Individuals in the Q5 group had a significantly greater likelihood of advanced glomerular sclerosis (OR 7.19, 95% CI 2.42-21.38) and advanced kidney arteriosclerosis (OR 5.28, 95% CI 1.77-15.80) than individuals in the Q1 group after adjusting for potential covariates. There was no evidence of significant associations of SUA levels with either the arteriolar hyalinosis index or the presence of advanced arteriolar hyalinosis. CONCLUSIONS: Elevated SUA levels were significantly associated with advanced glomerular sclerosis and advanced kidney arteriosclerosis, but not with advanced arteriolar hyalinosis in community-based autopsy samples of Japanese.

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  • 日本の地域住民における体重変化と心血管リスクプロファイルの同時変化 久山町研究(Changes in Body Weight and Concurrent Changes in Cardiovascular Risk Profiles in Community Residents in Japan: the Hisayama Study)

    Honda Takanori, Ishida Yuki, Oda Masaaki, Noguchi Kenichi, Chen Sanmei, Sakata Satoko, Oishi Emi, Furuta Yoshihiko, Yoshida Daigo, Hirakawa Yoichiro, Hata Jun, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   29 ( 2 )   252 - 267   2022.2   ISSN:1340-3478

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    体重変化が、モデルから予測される心血管疾患(CVD)の包括的リスクと個々の心血管リスクの変化に及ぼす影響について検討した。久山町研究の縦断データを用いて、2002年と2007年の健康診断に参加した40~74歳の地域住民2140名を対象に解析を行った。BMI 25kg/m2以上を肥満とし、2002年と2007年のBMIにより、「安定肥満」(両年とも肥満)、「肥満から非肥満」、「非肥満から肥満」、「安定非肥満」(両年とも肥満)に分類した。CVDの推定累積リスクおよびCVDリスク因子の2002年から2007年にかけての変化を群間比較した。2140名を解析対象とした。CVDの推定リスクは、2007年にかけて全ての群で増加した。CVDの推定リスクの増加は、「肥満から非肥満」群で最も小さく、「非肥満から肥満」群で最も大きかった。「肥満から非肥満」群は「安定肥満」群よりもウエスト周囲長、血圧、空腹時血糖値、血清HDLコレステロール値、血清トリグリセリド値、肝酵素の望ましい変化量が大きかった。全変数について、「非肥満から肥満」群と「安定非肥満」群では逆の傾向が認められた。以上から、肥満者での減量および非肥満者での過剰な体重増加の回避と、CVD包括的リスクおよび個々のCVDリスク要因に望ましい関連が認められた。

  • A Comparative Study of Site-Specific Distribution of Aging-Related Tau Astrogliopathy and Its Risk Factors Between Alzheimer Disease and Cognitive Healthy Brains: The Hisayama Study. International journal

    Kaoru Yagita, Hiroyuki Honda, Tomoyuki Ohara, Hideomi Hamasaki, Sachiko Koyama, Hideko Noguchi, Akane Mihara, Taro Nakazawa, Jun Hata, Toshiharu Ninomiya, Toru Iwaki

    Journal of neuropathology and experimental neurology   81 ( 2 )   106 - 116   2022.1   ISSN:0022-3069 eISSN:1554-6578

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    Knowledge of aging-related tau astrogliopathy (ARTAG) in healthy elderly individuals remains incomplete and studies to date have not focused on the olfactory nerve, which is a vulnerable site of various neurodegenerative disease pathologies. We performed a semiquantitative evaluation of ARTAG in 110 autopsies in the Japanese general population (Hisayama study). Our analysis focused on Alzheimer disease (AD) and cognitive healthy cases (HC), including primary age-related tauopathy. Among the various diseased and nondiseased brains, ARTAG was frequently observed in the amygdala. The ARTAG of HC was exclusively limited to the amygdala whereas gray matter ARTAG in AD cases was prominent in the putamen and middle frontal gyrus following the amygdala. ARTAG of the olfactory nerve mainly consists of subpial pathology that was milder in the amygdala. A logistic regression analysis revealed that age at death and neurofibrillary tangle Braak stage significantly affected the ARTAG of HC. In AD, age at death and male gender had significant effects on ARTAG. In addition, the Thal phase significantly affected the presence of white matter ARTAG. In conclusion, our research revealed differences in the distribution of ARTAG and affected variables across AD and HC individuals.

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  • 地域住民における認知症コホート研究:久山町研究

    Ninomiya Toshiharu

    Iryo To Shakai   31 ( 4 )   495 - 507   2022.1   ISSN:09169202 eISSN:18834477

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  • Stroke genetics informs drug discovery and risk prediction across ancestries

    Stéphanie Debette, Aniket Mishra, Rainer Malik, Tsuyoshi Hachiya, Tuuli Jürgenson, Shinichi Namba, Masaru Koido, Quentin Le Grand, Frederick Kamanu, Mingyang Shi, Yunye He, Marios Georgakis, Ilana Caro, Kristi Krebs, Felix Vaura, Naomi Habib, Bendik Winsvold, Yon Ho Jee, Jesper Qvist Thomassen, Vida Abedi, Jara Cárcel-Márquez, Kuang Lin, Marianne Nygaard, Ganesh Chauhan, Hampton Leonard, Chaojie Yang, Ekaterina Yonova-Doing, Maria Knol, Tetsuro Ago, Philippe Amouyel, Christopher Anderson, Nicole Armstrong, Mark Bakker, Traci Bartz, Joshua Bis, Constance Bordes, Sigrid Borte, Anael Cain, Paul Ridker, Zhengming Chen, Michael Chong, John Cole, Rafael de Cid, Matthias Endres, Leslie Ferreira, Natalie Gasca, Vilmundur Gudnason, Jun Hata, Aki Havulinna, Jemma Hopewell, Hyacinth Hyacinth, Michael Inouye, Mina Jacob, Christina  Jeon, Christina Jern, Masahiro Kamouchi, Keith Keene, Takanari Kitazono, Steven Kittner, Takahiro Konuma, Amit Kumar, Paul Lacaze, Lenore Launer, Kaido Lepik, Jiang Li, Liming Li, Ani Manichaikul, Hugh Markus, Nicholas Marston, Thomas Meitinger, Braxton Mitchell, Felipe Montellano, Takayuki Morisaki, Thomas Mosley, Mike Nalls, Børge Nordestgaard, Martin O'Donnell, Yukinori Okada, Guillaume Pare, Annette Peters, Bruce Psaty, Stephen Rich, Jonathan Rosand, Marc Sabatine, Ralph Sacco, Danish Saleheen, Else Charlotte Sandset, Muralidharan Sargurupremraj, Makoto Sasaki, Claudia Satizabal, Carsten Schmidt, Atsushi Shimizu, Nicholas Smith, Daniel Strbian, Yoichi Sutoh, Kozo Tanno, Steffen Tiedt, Nuria Torres-Aguila, David-Alexandre Trégouët, Stella Trompet, Anil Tuladhar, Anne Tybjærg-Hansen, Marion van Vugt, Riina Vibo, Kerri Wiggins, Daniel Woo, Huichun Xu, Qiong Yang, Mark Lathrop, Iona Millwood, Christian Gieger, Toshiharu Ninomiya, Hans Grabe, J Wouter Jukema, Ina Rissanen, Sudha Seshadri, William Longstreth, Daniel Chasman, Joanna Howson, Marguerite Irvin, Hieab Adams, Sylvia Wasssertheil-Smoller, Kaare Christensen, M. Arfan Ikram, Tatjana Rundek, Jerome Rotter, Moeen Riaz, Eleanor Simonsick, Janika Kõrv, Paulo França, Myriam Fornage, Ramin Zand, Kameshwar Prasad, Ruth Frikke-Schmidt, Frank-Erik de Leeuw, Thomas Liman, Karl Georg Haeusler, Ynte Ruigrok, Peter Heuschmann, Keum Jung, John-Anker Zwart, Teemu Niiranen, Christian Ruff, Israel Fernández-Cadenas, Robin Walters, Lili Milani, Yoichiro Kamatani, Martin Dichgans

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    Previous genome-wide association studies (GWAS) of stroke, the second leading cause of death, have been conducted in populations of predominantly European ancestry.1,2 We undertook cross-ancestry GWAS meta-analyses of stroke and its subtypes in 110,182 stroke patients (33% non-European) and 1,503,898 control individuals of five ancestries from population- and clinic-based studies, nearly doubling the number of cases in previous stroke GWAS. We identified association signals at 89 independent loci, of which 61 were novel. Effect sizes were overall highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis using a novel machine-learning approach,3 transcriptome and proteome-wide association analyses revealed putative causal genes (e.g. SH3PXD2A and FURIN) and variants (e.g. at GRK5 and NOS3). Using a novel three-pronged approach,4 we provided genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWAS with vascular risk factor GWAS (iPGS) showed strong prediction of ischemic stroke risk in European and, for the first time, East-Asian populations.5,6 The iPGS performed better than stroke PGS alone and better than previous best iPGS, in Europeans and East-Asians. Transferability of European-specific iPGS to East-Asians was limited. Stroke genetic risk scores were predictive of ischemic stroke independent of clinical risk factors in 52,600 clinical trial participants with cardiometabolic disease and performed considerably better than previous scores, both in Europeans and East-Asians. Altogether our results provide critical insight to inform biology, reveal potential drug targets for intervention, and provide genetic risk prediction tools across ancestries for targeted prevention.

    DOI: 10.21203/rs.3.rs-1175817/v1

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  • A Comparative Study of Site-Specific Distribution of Aging-Related tau astrogliopathy and its risk factors between alzheimer disease and cognitive healthy brains: the Hisayama Study. Invited Reviewed International journal

    Yagita K, Honda H, Ohara T, Hamasaki H, Koyama S, Noguchi H, Mihara A, Nakazawa T, Hata J, Ninomiya T, Iwaki T

    J Neuropathol Exp Neurol   81   106 - 116   2022.1

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  • Prevalence of chronic kidney disease in Asia: a systematic review and analysis. Invited Reviewed International journal

    Liyanage T, Toyama T, Hockham C, Ninomiya T, Perkovic V, Woodward M, Fukagawa M, Matsushita K, Praditpornsilpa K, Hooi LS, Iseki K, Lin MY, Stirnadel-Farrant HA, Jha V, Jun M

    BMJ Glob Health   7   e007525   2022.1

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  • Concurrent cardiac transthyretin and brain β amyloid accumulation among the older adults: the Hisayama Study. Invited Reviewed International journal

    Hamasaki H, Shijo M, Nakamura A, Honda H, Yamada Y, Oda Y, Ohara T, Ninomiya T, Iwaki T

    Brain Pathol   32   e13014   2022.1

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  • Concurrent cardiac transthyretin and brain β amyloid accumulation among the older adults: The Hisayama study. International journal

    Hideomi Hamasaki, Masahiro Shijo, Ayaka Nakamura, Hiroyuki Honda, Yuichi Yamada, Yoshinao Oda, Tomoyuki Ohara, Toshiharu Ninomiya, Toru Iwaki

    Brain pathology (Zurich, Switzerland)   32 ( 1 )   e13014   2022.1   ISSN:1015-6305 eISSN:1750-3639

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    Previous studies have revealed risk for cognitive impairment in cardiovascular diseases. We investigated the relationship between degenerative changes of the brain and heart, with reference to Alzheimer's disease (AD) pathologies, cardiac transthyretin amyloid (ATTR) deposition, and cardiac fibrosis. A total of 240 consecutive autopsy cases of a Japanese population-based study were examined. β amyloid (Aβ) of senile plaques, phosphorylated tau protein of neurofibrillary tangles, and ATTR in the hearts were immunohistochemically detected and graded according to the NIH-AA guideline for AD pathology and as Tanskanen reported, respectively. Cerebral amyloid angiopathy (CAA) was graded according to the Vonsattel scale. Cardiac fibrosis was detected by picrosirius red staining, followed by image analysis. Cardiac ATTR deposition occurred after age 75 years and increased in an age-dependent manner. ATTR deposition was more common, and of higher grades, in the dementia cases. We subdivided the cases into two age groups: ≤90 years old (n = 173) and >90 years old (n = 67), which was the mean and median age at death of the AD cases. When adjusted for age and sex, TTR deposition grades correlated with Aβ phase score (A2-3), the Consortium to Establish a Registry for AD score (sparse to frequent), and high Braak stage (V-VI) only in those aged ≤90 years at death. No significant correlation was observed between the cardiac ATTR deposition and CAA stages, or between cardiac fibrosis and AD pathologies. Collectively, AD brain pathology correlated with cardiac TTR deposition among the older adults ≤90 years.

    DOI: 10.1111/bpa.13014

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  • Prevalence of Glaucoma and Its Systemic Risk Factors in a General Japanese Population: The Hisayama Study. International journal

    Kohta Fujiwara, Miho Yasuda, Jun Hata, Satoko Nakano, Sawako Hashimoto, Emi Ueda, Shun Nakamura, Yusuke Murakami, Takako Nakamuro, Aiko Iwase, Makoto Araie, Akihiko Tawara, Toshiaki Kubota, Takeshi Yoshitomi, Toshiharu Ninomiya, Koh-Hei Sonoda

    Translational vision science & technology   11 ( 1 )   11 - 11   2022.1   ISSN:2164-2591

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    PURPOSE: To estimate the prevalence of glaucoma and its risk factors in a Japanese community. METHODS: This study included 3405 Japanese community dwellers who were ≥40 years of age and enrolled in the Hisayama Study. This population-based, cross-sectional study was conducted from 2017 to 2018. A glaucoma screening test was performed using stereo fundus images and swept-source optical coherence tomography. Glaucoma was defined based on the International Society of Geographical and Epidemiological Ophthalmology criteria. RESULTS: The prevalence of glaucoma was 7.6% (95% confidence interval [CI], 6.7-8.6) overall. The prevalence of primary open-angle glaucoma (POAG) was 5.8% (95% CI, 5.0-6.6); that of primary angle-closure glaucoma (PACG) was 0.7% (95% CI, 0.5-1.1); and that of exfoliation glaucoma was 1.1% (95% CI, 0.7-1.4). In addition to aging, lower estimated glomerular filtration rate (eGFR) (odds ratio [OR] = 1.15; 95% CI, 1.02-1.33), higher intraocular pressure (OR = 1.06; 95% CI, 1.01-1.12), longer axial length (OR = 1.44; 95% CI, 1.31-1.59), and thinner central corneal thickness (CCT) (OR = 1.09; 95% CI, 1.04-1.15) were significant risk factors for POAG. Diabetes (OR = 2.81; 95% CI, 1.19-6.62) was a significant risk factor for PACG, and diabetes (OR = 2.15; 95% CI, 1.03-4.47) and thinner CCT (OR = 1.14; 95% CI, 1.02-1.28) were significant risk factors for exfoliation glaucoma. CONCLUSIONS: The prevalence of glaucoma was approximately 8%, probably due to the increase in the Japanese aging population. Not only ocular factors but also lower eGFR for POAG and diabetes for PACG and exfoliation glaucoma were risk factors in a general Japanese population. TRANSLATIONAL RELEVANCE: Systemic factors such as eGFR and diabetes must also be considered when implementing preventive measures against glaucoma.

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  • Prevalence of chronic kidney disease in Asia: a systematic review and analysis. International journal

    Thaminda Liyanage, Tadashi Toyama, Carinna Hockham, Toshiharu Ninomiya, Vlado Perkovic, Mark Woodward, Masafumi Fukagawa, Kunihiro Matsushita, Kearkiat Praditpornsilpa, Lai Seong Hooi, Kunitoshi Iseki, Ming-Yen Lin, Heide A Stirnadel-Farrant, Vivekanand Jha, Min Jun

    BMJ global health   7 ( 1 )   2022.1   ISSN:2059-7908

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    INTRODUCTION: The burden of chronic kidney disease (CKD) is growing rapidly around the world. However, there is limited information on the overall regional prevalence of CKD, as well as the variations in national prevalence within Asia. We aimed to consolidate available data and quantify estimates of the CKD burden in this region. METHODS: We systematically searched MEDLINE, Embase and Google Scholar for observational studies and contacted national experts to estimate CKD prevalence in countries of Asia (Eastern, Southern and South Eastern Asia). CKD was defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 or the presence of proteinuria. For countries without reported data, we estimated CKD prevalence using agglomerative average-linkage hierarchical clustering, based on country-level risk factors and random effects meta-analysis within clusters. Published CKD prevalence data were obtained for 16 countries (of the 26 countries in the region) and estimates were made for 10 countries. RESULTS: There was substantial variation in overall and advanced (eGFR <30 mL/min/1.73 m2) CKD prevalence (range: 7.0%-34.3% and 0.1%-17.0%, respectively). Up to an estimated 434.3 million (95% CI 350.2 to 519.7) adults have CKD in Asia, including up to 65.6 million (95% CI 42.2 to 94.9) who have advanced CKD. The greatest number of adults living with CKD were in China (up to 159.8 million, 95% CI 146.6 to 174.1) and India (up to 140.2 million, 95% CI 110.7 to 169.7), collectively having 69.1% of the total number of adults with CKD in the region. CONCLUSION: The large number of people with CKD, and the substantial number with advanced CKD, show the need for urgent collaborative action in Asia to prevent and manage CKD and its complications.

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  • Diabetes Mellitus, Elevated Hemoglobin A1c, and Glycated Albumin Are Associated with the Presence of All-Cause Dementia and Alzheimer's Disease: The JPSC-AD Study. International journal

    Moeko Noguchi-Shinohara, Sohshi Yuki-Nozaki, Chiemi Abe, Ayaka Mori, Mai Horimoto, Masami Yokogawa, Natsuko Ishida, Yukio Suga, Junko Ishizaki, Mai Ishimiya, Hiroyuki Nakamura, Kiyonobu Komai, Hiroyuki Nakamura, Mao Shibata, Tomoyuki Ohara, Jun Hata, Toshiharu Ninomiya, Masahito Yamada

    Journal of Alzheimer's disease : JAD   85 ( 1 )   235 - 247   2022   ISSN:1387-2877 eISSN:1875-8908

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    BACKGROUND: Glucose dysmetabolism is an important risk factor for dementia. OBJECTIVE: We investigated the associations of diabetes mellitus, the levels of glycemic measures, and insulin resistance and secretion measures with dementia and its subtypes in a cross-sectional study. METHODS: In this study, 10,214 community-dwelling participants were enrolled. Hemoglobin A1c (HbA1c), the homeostasis model assessment (HOMA) for insulin resistance (HOMA-IR), the HOMA of percent β-cell function (HOMA-β), and the glycated albumin (GA) was evaluated. The associations of each measure with Alzheimer's disease (AD) and vascular dementia (VaD) were investigated. RESULTS: The multivariable-adjusted odds ratios (ORs) of AD were significantly higher in participants with diabetes mellitus than in those without diabetes (1.46 [95% CI: 1.08-1.97]). Higher HbA1c levels were significantly associated with AD at diabetes (≥6.5%) and even at prediabetes (5.7 %-6.4 %) levels; multivariable-adjusted ORs for AD in participants at the diabetes level were 1.72 (95% CI: 1.19-2.49), and those in participants at the prediabetes level were 1.30 (95% CI: 1.00-1.68), compared with those in normal participants. Moreover, higher GA levels were associated with AD. No associations were observed between the diabetic status or the levels of glycemic measures and VaD. In addition, no significant relationships were observed between insulin resistance and secretion measurements and AD and VaD. CONCLUSION: Our findings indicate that diabetes mellitus and hyperglycemia are significantly associated with AD, even in individuals at the prediabetes level.

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  • Serum Lipopolysaccharide-binding Protein Levels and the Incidence of Metabolic Syndrome in a General Japanese Population: the Hisayama Study Reviewed

    二宮 利治

    J Epidemiol   -   2022

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    本田 貴紀, 二宮 利治

    Japanese Journal of Physical Fitness and Sports Medicine   71 ( 1 )   44 - 44   2022   ISSN:0039906X eISSN:18814751

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    DOI: 10.7600/jspfsm.71.44

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  • 特別教育講演1「健診データを用いた臨床研究の実際」

    二宮 利治

    Health Evaluation and Promotion   49 ( 1 )   92 - 92   2022   ISSN:13470086 eISSN:18844103

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    DOI: 10.7143/jhep.49.92

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  • MUTYH actively contributes to microglial activation and impaired neurogenesis in the pathogenesis of alzheimer's disease. Invited Reviewed International journal

    Mizuno Y, Abolhassani N, Mazzei G, Sakumi K, Saito T, Saido TC, Ninomiya T, Iwaki T, Yamasaki R, Kira JI, Nakabeppu Y

    Oxid Med Cell Longev   8635088   2021.12

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  • Prediction of lifetime risk of cardiovascular disease deaths stratified by sex in the Japanese population. Invited Reviewed International journal

    Imai Y, Mizuno Tanaka S, Satoh M, Hirata T, Murakami Y, Miura K, Waki T, Hirata A, Sairenchi T, Irie F, Sata M, Ninomiya T, Ohkubo T, Ishikawa S, Miyamoto Y, Ohnishi H, Saitoh S, Tamakoshi A, Yamada M, Kiyama M, Iso H, Sakata K, Nakagawa H, Okayama A, Ues

    J Am Heart Assoc 10: e021753, 2021   10   e021753   2021.12

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  • Risk Classification for Metabolic Syndrome and the Incidence of cardiovascular disease in Japan with low prevalence of obesity: a pooled analysis of 10 prospective cohort studies. Invited Reviewed International journal

    Iso H, Cui R, Takamoto I, Kiyama M, Saito I, Okamura T, Miyamoto Y, Higashiyama A, Kiyohara Y, Ninomiya T, Yamada M, Nakagawa H, Sakurai M, Shimabukuro M, Higa M, Shimamoto K, Saito S, Daimon M, Kayama T, Noda M, Ito S, Yokote K, Ito C, Nakao K, Yamauchi

    J Am Heart Assoc   10   e020760   2021.12

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  • Pathological review of cardiac amyloidosis using autopsy cases in a single Japanese institution. Invited Reviewed International journal

    Tateishi Y, Yamada Y, Katsuki M, Nagata T, Yamamoto H, Kohashi K, Koga Y, Hashisako M, Kiyozawa D, Mori T, Kuboyama Y, Kakinokizono A, Miyazaki Y, Yamaguchi A, Tsutsui H, Ninomiya T, Naiki H, Oda Y

    Pathol Res Pract   227   153635   2021.11

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  • Emotional loneliness is associated with a risk of dementia in a general Japanese older population: the Hisayama Study. Invited Reviewed International journal

    Shibata M, Ohara T, Hosoi M, Hata J, Yoshida D, Hirabayashi N, Morisaki Y, Nakazawa T, Mihara A, Nagata T, Oishi E, Anno K, Sudo N, Ninomiya T

    J Gerontol B Psychol Sci Soc Sci   76   1756 - 1766   2021.10

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  • Midlife and late-life diabetes and sarcopenia in a general older Japanese population: the Hisayama Study. Invited Reviewed International journal

    Nakamura K, Yoshida D, Honda T, Hata J, Shibata M, Hirakawa Y, Furuta Y, Kishimoto H, Ohara T, Chen S, Kitazono T, Nakashima Y, Ninomiya T

    J Diabetes Investig   12   1899 - 1907   2021.10

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  • Pathologic diabetic nephropathy in autopsied diabetic cases with normoalbuminuria from a Japanese community-based study. Invited Reviewed International journal

    Sasaki T, Nakagawa K, Hata J, Hirakawa Y, Shibata M, Nakano T, Tsuboi N, Oda Y, Kitazono T, Yokoo T, Ninomiya T

    Kidney Int Rep   6   3035 - 3044   2021.9

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  • Development of a risk prediction model for incident hypertension in Japanese individuals: the Hisayama Study. Invited Reviewed International journal

    Oishi E, Hata J, Honda T, Sakata S, Chen S, Hirakawa Y, Yoshida D, Shibata M, Ohara T, Furuta Y, Kitazono T, Ninomiya T

    Hypertens Res   44   1221 - 1229   2021.9

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  • Serum NT-proBNP levels and histopathological myocardial fibrosis in autopsied cases from a Japanese community: the Hisayama Study. Invited Reviewed International journal

    Sasaki T, Izumaru K, Hata J, Sakata S, Oishi E, Nagata T, Tsuboi N, Oda Y, Kitazono T, Yokoo T, Ninomiya T

    J Cardiol   78   237 - 243   2021.9

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  • Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Invited Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC)( Ninomiya T, Hata J)

    Lancet   398   957 - 980   2021.9

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  • the Committee for Renal Biopsy and Disease Registry of the Clinical and histological features in pediatric and adolescent/young adult patients with renal disease: a cross-sectional analysis of the Japan Renal Biopsy Registry (J-RBR). Invited Reviewed International journal

    Urushihara M, Sato H, Shimizu A, Sugiyama H, Yokoyama H, Hataya H, Matsuoka K, Okamoto T, Ogino D, Miura K, Hamada R, Hibino S, Shima Y, Yamamura T, Kitamoto K, Ishihara M, Konomoto T, Hattori M;

    Clin Exp Nephrol   25   1018 - 1026   2021.9

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  • 10-year trend of tooth loss and associated factors in a Japanese population-based longitudinal study. Reviewed International journal

    Furuta M, Takeuchi K, Takeshita T, Shibata Y, Suma S, Kageyama S, Asakawa M, Hata J, Yoshida D, Shimazaki Y, Ninomiya T, Yamashita Y

    BMJ Open   11   2021.8

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  • Comparison of the contributions of impaired beta cell function and insulin resistance to the development of type 2 diabetes in a Japanese community: the Hisayama Study. Invited Reviewed International journal

    Yoshinari M, Hirakawa Y, Hata J, Higashioka M, Honda T, Yoshida D, Mukai N, Nakamura U, Kitazono T, Ninomiya T

    Diabetologia   64   1775 - 1784   2021.8

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  • Association between socioeconomic status and physical inactivity in a general Japanese population: NIPPON DATA2010. Invited Reviewed International journal

    Sumimoto Y, Yanagita M, Miyamatsu N, Okuda N, Nishi N, Nakamura Y, Nakamura K, Miyagawa N, Miyachi M, Kadota A, Ohkubo T, Okamura T, Ueshima H, Okayama A, Miura K; for NIPPON DATA2010 Research Group( Kiyohara Y, Ninomiya T)

    PLoS One   16   e0254706   2021.7

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  • Development of a dementia prediction model for primary care: the Hisayama Study. Invited Reviewed International journal

    Honda T, Ohara T, Yoshida D, Shibata M, Ishida Y, Furuta Y, Oishi E, Hirakawa Y, Sakata S, Hata J, Nakao T, Ninomiya T

    Alzheimers Dement (Amst)   13   e12221   2021.7

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  • Serum high-sensitivity C-reactive protein Levels and the development of atrial fibrillation in a general Japanese population - the Hisayama Study. Invited Reviewed International journal

    Yoshikawa T, Hata J, Sakata S, Nagata T, Hirakawa Y, Hirooka Y, Tsutsui H, Kitazono T, Ninomiya T

    Circ J   85   1365 - 1372   2021.7

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  • Risk prediction model for incident atrial fibrillation in a general Japanese population - the Hisayama Study. Invited Reviewed International journal

    Hata J, Nagata T, Sakata S, Oishi E, Furuta Y, Hirakawa Y, Honda T, Yoshida D, Kitazono T, Ninomiya T

    Circ J   85   1373 - 1382   2021.7

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  • Combined changes in albuminuria and kidney function and subsequent risk for kidney failure in type 2 diabetes. Invited Reviewed International journal

    Oshima M, Toyama T, Hara A, Shimizu M, Kitajima S, Iwata Y, Sakai N, Furuichi K, Haneda M, Babazono T, Yokoyama H, Iseki K, Araki SI, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Makino H, Wada T

    BMJ Open Diabetes Res Care   9   2021.6

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  • N-terminal pro-B-type natriuretic peptide and incident CKD. Invited Reviewed International journal

    Sasaki T, Oishi E, Nagata T, Sakata S, Chen S, Furuta Y, Honda T, Yoshida D, Hata J, Tsuboi N, Kitazono T, Yokoo T, Ninomiya T

    Kidney Int Rep   6   976 - 985   2021.6

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  • Cohort Profile: The Ganka-Ekigaku Network (GEN), a network of Japanese ophthalmological epidemiology studies. Invited Reviewed International journal

    Sasaki M, Miyake M, Fujiwara K, Nanba H, Akiyama M, Yanagi Y, Harada S, Tabara Y, Yasuda M, Yamashita H, Kayama T, Tsubota K, Matsuda F, Hashimoto S, Ueda E, Ninomiya T, Takebayashi T, Tsujikawa A, Sonoda KH, Kawasaki R

    Ophthalmic Epidemiol   237 - 243   2021.6

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  • Qian F, Ardisson Korat AV, Imamura F, Marklund M, Tintle N, Virtanen JK, Zhou X, Bassett JK, Lai H, Hirakawa Y, Chien KL, Wood AC, Lankinen M, Murphy RA, Samieri C, Pertiwi K, de Mello VD, Guan W, Forouhi NG, Wareham N, Hu ICFB, Riserus U, Lind L, Harris Invited Reviewed International journal

    n-3 fatty acid biomarkers and incident type 2 diabetes: an individual participant-level pooling project of 20 prospective cohort studies.

    Diabetes Care   44   1133 - 1142   2021.5

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  • Prevalence and mortality of sarcopenia in a community-dwelling older Japanese population: the Hisayama Study. Invited Reviewed International journal

    Nakamura K, Yoshida D, Honda T, Hata J, Shibata M, Hirakawa Y, Furuta Y, Kishimoto H, Ohara T, Kitazono T, Nakashima Y, Ninomiya T

    J Epidemiol   31   320 - 327   2021.5

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  • Airflow limitation and tongue microbiota in community-dwelling elderly individuals. Invited Reviewed International journal

    Takeshita T, Matsumoto K, Furuta M, Fukuyama S, Takeuchi K, Ogata H, Asakawa M, Kageyama S, Hata J, Ninomiya T, Inoue H, Yamashita Y

    ERJ Open Res   7   2021.5

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  • Current status of the certification of long-term care insurance among individuals with dementia in a Japanese community: the Hisayama Study. Invited Reviewed International journal

    Ohara T, Yoshida D, Hata J, Shibata M, Honda T, Furuta Y, Hirabayashi N, Kitazono T, Nakao T, Ninomiya T

    Psychiatry Clin Neurosci   75   182 - 184   2021.5

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  • Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies. Invited Reviewed International journal

    Harris WS, Tintle NL, Imamura F, Qian F, Korat AVA, Marklund M, Djoussé L, Bassett JK, Carmichael PH, Chen YY, Hirakawa Y, Küpers LK, Laguzzi F, Lankinen M, Murphy RA, Samieri C, Senn MK, Shi P, Virtanen JK, Brouwer IA, Chien KL, Eiriksdottir G, Forouhi N

    Nat Commun   12   2329   2021.4

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  • Urinary N-terminal pro-B-type natriuretic peptide as a biomarker for cardiovascular events in a general Japanese population: the Hisayama Study. Invited Reviewed International journal

    Yamasaki K, Hata J, Ide T, Nagata T, Sakata S, Yoshida D, Honda T, Hirakawa Y, Nakano T, Kitazono T, Tsutsui H, Ninomiya T

    Environ Health Prev Med   26   47   2021.4

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  • Dietary fiber intake and risk of type 2 diabetes in a general Japanese population: the Hisayama Study. Invited Reviewed International journal

    Kimura Y, Yoshida D, Hirakawa Y, Hata J, Honda T, Shibata M, Sakata S, Uchida K, Kitazono T, Ninomiya T

    J Diabetes Investig   12   527 - 536   2021.4

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  • Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Invited Reviewed International journal

    Gharahkhani P, Jorgenson E, Hysi P, Khawaja AP, Pendergrass S, Han X, Ong JS, Hewitt AW, Segrè AV, Rouhana JM, Hamel AR, Igo RP Jr, Choquet H, Qassim A, Josyula NS, Cooke Bailey JN, Bonnemaijer PWM, Iglesias A, Siggs OM, Young TL, Vitart V, Thiadens AAHJ,

    Nat Commun   12   1258   2021.3

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  • Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight. Invited Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC)(Ninomiya T, Hata J)

    Elife   10   2021.3

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  • Risk prediction for new-onset atrial fibrillation using the Minnesota code electrocardiography classification system. Invited Reviewed International journal

    Igarashi Y, Nochioka K, Sakata Y, Tamai T, Ohkouchi S, Irokawa T, Ogawa H, Hayashi H, Fujihashi T, Yamanaka S, Shiroto T, Miyata S, Hata J, Yamada S, Ninomiya T, Yasuda S, Kurosawa H, Shimokawa H

    Int J Cardiol Heart Vasc   34   2021.3

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  • High serum folate concentrations are associated with decreased risk of mortality among Japanese adults. Invited Reviewed International journal

    Chen S, Honda T, Hata J, Sakata S, Furuta Y, Yoshida D, Shibata M, Ohara T, Hirakawa Y, Oishi E, Kitazono T, Ninomiya T

    J Nutr   151   657 - 665   2021.3

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  • PCBP2 is downregulated in degenerating neurons and rarely observed in TDP-43-Positive inclusions in sporadic amyotrophic lateral sclerosis. Invited Reviewed International journal

    Yoshimura M, Honda H, Sasagasako N, Mori S, Hamasaki H, Suzuki SO, Ishii T, Ninomiya T, Kira JI, Iwaki T

    J Neuropathol Exp Neurol   80   220 - 228   2021.2

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  • Randomized trial of an intensified, multifactorial intervention in patients with advanced-stage diabetic kidney disease: Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT-Japan). Invited Reviewed International journal

    Shikata K, Haneda M, Ninomiya T, Koya D, Suzuki Y, Suzuki D, Ishida H, Akai H, Tomino Y, Uzu T, Nishimura M, Maeda S, Ogawa D, Miyamoto S, Makino H; Diabetic Nephropathy Remission and Regression Team Trial in Japan (DNETT-Japan) collaborative group

    J Diabetes Investig   12   207 - 216   2021.2

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  • The association of small dense low-density lipoprotein cholesterol and coronary heart disease in subjects at high cardiovascular risk. Invited Reviewed International journal

    Higashioka M, Sakata S, Honda T, Hata J, Shibata M, Yoshida D, Goto K, Kitazono T, Osawa H, Ninomiya T

    J Atheroscler Thromb   28   79 - 89   2021.1

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  • Recent status of self-measured home blood pressure in the Japanese general population: a modern database on self-measured home blood pressure (MDAS). Invited Reviewed International journal

    Asayama K, Tabara Y, Oishi E, Sakata S, Hisamatsu T, Godai K, Kabayama M, Tatsumi Y, Hata J, Kikuya M, Kamide K, Miura K, Ninomiya T, Ohkubo T

    Hypertens Res   43 ( 1403 )   1412   2020.12

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  • Serum N-terminal pro-B-type natriuretic peptide as a predictor for future development of atrial fibrillation in a general population: the Hisayama Study. Invited Reviewed International journal

    Nagata T, Hata J, Sakata S, Oishi E, Honda T, Furuta Y, Ohara T, Yoshida D, Hirakawa Y, Shibata M, Ide T, Kitazono T, Tsutsui H, Ninomiya T

    Int J Cardiol   320   90 - 96   2020.12

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  • Impact of hypertension stratified by diabetes on the lifetime risk of cardiovascular disease mortality in Japan: a pooled analysis of data from the Evidence for Cardiovascular Prevention from Observational Cohorts in Japan study. Invited Reviewed International journal

    Imai Y, Hirata T, Saitoh S, Ninomiya T, Miyamoto Y, Ohnishi H, Murakami Y, Iso H, Tanaka S, Miura K, Tamakoshi A, Yamada M, Kiyama M, Ueshima H, Ishikawa S, Okamura T; Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) Research Group

    Hypertens Res   43 ( 1437 )   1444   2020.11

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  • Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants. Invited Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC)(Ninomiya T, Hata J)

    Lancet   396   1511 - 1524   2020.11

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  • Usefulness of the SAGE score to predict elevated values of brachial-ankle pulse wave velocity in Japanese subjects with hypertension. Invited Reviewed International journal

    Tomiyama H, Vlachopoulos C, Xaplanteris P, Nakano H, Shiina K, Ishizu T, Kohro T, Higashi Y, Takase B, Suzuki T, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Tanaka A, Maemura K, Ohya Y, Furukawa T, Ito H, Ohkuma T, Ninomiya T, Chikamori T, Yamashina A, Ueda SI

    Hypertens Res   43   1284 - 1292   2020.11

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  • Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD). Reviewed International journal

    Ninomiya T, Nakaji S, Maeda T, Yamada M, Mimura M, Nakashima K, Mori T, Takebayashi M, Ohara T, Hata J, Kokubo Y, Uchida K, Taki Y, Kumagai S, Yonemoto K, Yoshida H, Muto K, Momozawa Y, Akiyama M, Kubo M, Ikeda M, Kanba S, Kiyohara Y; JPSFC-AD Study Group

    Environ Health Prev Med   25   64 - 76   2020.10

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  • Growth differentiation factor 15 and NT-proBNP as blood-based markers of vascular brain injury and dementia. Invited Reviewed International journal

    McGrath ER, Himali JJ, Levy D, Conner SC, DeCarli C, Pase MP, Ninomiya T, Ohara T, Courchesne P, Satizabal CL, Vasan RS, Beiser AS, Seshadri S

    J Am Heart Assoc   9   2020.10

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  • Influence of the accumulation of unhealthy eating habits on obesity in a general Japanese population: the Hisayama Study. Invited Reviewed International journal

    Ishida Y, Yoshida D, Honda T, Hirakawa Y, Shibata M, Sakata S, Furuta Y, Oishi E, Hata J, Kitazozno T, Ninomiya T

    Nutrients   12   2020.10

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  • Cohort profile: The Ganka-Ekigaku Network (GEN), a network of Japanese ophthalmological epidemiology studies. Invited Reviewed International journal

    Sasaki M, Miyake M, Fujiwara K, Nanba H, Akiyama M, Yanagi Y, Harada S, Tabara Y, Yasuda M, Yamashita H, Kayama T, Tsubota K, Matsuda F, Hashimoto S, Ueda E, Ninomiya T, Takebayashi T, Tsujikawa A, Sonoda KH, Kawasaki R

    Ophthalmic Epidemiol   13   1 - 7   2020.8

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  • Five-year incidence of myopic maculopathy in a general Japanese population: the Hisayama Study. Invited Reviewed International journal

    Ueda E, Yasuda M, Fujiwara K, Hashimoto S, Ohno-Matsui K, Hata J, Ishibashi T, Ninomiya T, Sonoda KH

    JAMA Ophthalmol 3, 2020   138   887 - 893   2020.8

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  • Association between serum glycated albumin and risk of cardiovascular disease in a Japanese community: the Hisayama Study. Invited Reviewed International journal

    Mihara A, Ohara T, Hata J, Honda T, Chen S, Sakata S, Oishi E, Hirakawa Y, Nakao T, Kitazono T, Ninomiya T

    Atherosclerosis   311   52 - 59   2020.8

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  • Parenting style during childhood is associated with the development of chronic pain and a patient's need for psychosomatic treatment in adulthood: A case-control study. Invited Reviewed International journal

    Shibata M, Ninomiya T, Anno K, Kawata H, Iwaki R, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M

    Medicine (Baltimore)   99   2020.8

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  • Lifetime cumulative incidence of dementia in a community-dwelling elderly population in Japan. Invited Reviewed International journal

    Yoshida D, Ohara T, Hata J, Shibata M, Hirakawa Y, Honda T, Furuta Y, Oishi E, Sakata S, Kanba S, Kitazono T, Ninomiya T

    Neurology   95   2020.8

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  • Nephron number and time to remission in steroid-sensitive minimal change disease. Invited Reviewed International journal

    Sasaki T, Tsuboi N, Marumoto H, Okabayashi Y, Haruhara K, Kanzaki G, Koike K, Ogura M, Ninomiya T, Yokoo T

    Kidney Med   2   559 - 568   2020.8

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  • Small dense low-density lipoprotein cholesterol and the risk of coronary heart disease in a Japanese community. Invited Reviewed International journal

    Higashioka M, Sakata S, Honda T, Hata J, Yoshida D, Hirakawa Y, Shibata M, Goto K, Kitazono T, Osawa H, Ninomiya T

    J Atheroscler Thromb   27   669 - 682   2020.7

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  • 30-minute postload plasma glucose levels during an oral glucose tolerance test predict the risk of future type 2 diabetes: the Hisayama Study Invited Reviewed International journal

    Hirakawa Y, Hata J, Yoshinari M, Higashioka M, Yoshida D, Shibata M, Honda T, Sakata S, Kato H, Teramoto T, Maki H, Nishimoto S, Kitazono T, Ninomiya T

    BMJ Open Diabetes Res Care   8   2020.7

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  • Elevated serum glycated albumin and glycated albumin : hemoglobin A(1c) ratio were associated with hippocampal atrophy in a general elderly population of Japanese: the Hisayama Study. Invited Reviewed International journal

    Ohara T, Furuta Y, Hirabayashi N, Hata J, Hirakawa Y, Honda T, Yoshida D, Shibata M, Kitazono T, Ninomiya T

    J Diabetes Investig   11   971 - 979   2020.7

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  • Repositioning of the global epicentre of non-optimal cholesterol. Invited Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC)(Ninomiya T, Hata J)

    Nature   582   73 - 77   2020.6

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  • Serum uric acid levels and cardiovascular mortality in a general Japanese population: the Hisayama Study. Invited Reviewed International journal

    Sakata S, Hata J, Honda T, Hirakawa Y, Oishi E, Shibata M, Yoshida D, Goto K, Kitazono T, Ninomiya T

    Hypertens Res   43   560 - 568   2020.6

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  • Association of albuminuria with white matter hyperintensities volume on brain magnetic resonance imaging in elderly Japanese - the Hisayama Study. Invited Reviewed International journal

    Yamasaki K, Hata J, Furuta Y, Hirabayashi N, Ohara T, Yoshida D, Hirakawa Y, Nakano T, Kitazono T, Ninomiya T

    Circ J   84   935 - 942   2020.5

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  • Serum homocysteine and risk of dementia in Japan. Invited Reviewed International journal

    Chen S, Honda T, Ohara T, Hata J, Hirakawa Y, Yoshida D, Shibata M, Sakata S, Oishi E, Furuta Y, Kitazono T, Ninomiya T

    J Neurol Neurosurg Psychiatry   91   540 - 546   2020.5

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  • Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia. Invited Reviewed International journal

    Lee CM, Woodward M, Batty GD, Beiser AS, Bell S, Berr C, Bjertness E, Chalmers J, Clarke R, Dartigues JF, Davis-Plourde K, Debette S, Di Angelantonio E, Feart C, Frikke-Schmidt R, Gregson J, Haan MN, Hassing LB, Hayden KM, Hoevenaar-Blom MP, Kaprio J, Kivimaki M, Lappas G, Larson EB, LeBlanc ES, Lee A, Lui LY, Moll van Charante EP, Ninomiya T, Nordestgaard LT, Ohara T, Ohkuma T, Palviainen T, Peres K, Peters R, Qizilbash N, Richard E, Rosengren A, Seshadri S, Shipley M, Singh-Manoux A, Strand BH, van Gool WA, Vuoksimaa E, Yaffe K, Huxley RR

    Obes Rev 21: e12989, 2020   2020.4

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  • 睡眠呼吸障害と診断された一般住民の受療行動に影響を及ぼす要因の検討. Invited Reviewed

    藤田香奈恵, 宮園真美, 姜 旻廷, 森山宣子, 吉田大悟, 柴田舞欧, 安藤眞一, 二宮利治, 樗木晶子

    日循予防誌   55   17 - 28   2020.3

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  • Ratios of serum eicosapentaenoic acid to arachidonic acid and docosahexaenoic acid to arachidonic acid were inversely associated with serum resistin levels: the Hisayama Study. Invited Reviewed International journal

    Higashioka M, Hirakawa Y, Kawamura R, Honda T, Hata J, Yoshida D, Takata Y, Kitazono T, Osawa H, Ninomiya T

    J Diabetes Investig   11   482 - 489   2020.3

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  • Genome-wide polygenic score and the risk of ischemic stroke in a prospective cohort: the Hisayama Study. Invited Reviewed International journal

    Hachiya T, Hata J, Hirakawa Y, Yoshida D, Furuta Y, Kitazono T, Shimizu A, Ninomiya T

    Stroke 51: 759-765   51   759 - 765   2020.3

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  • Disrupted tongue microbiota and detection of nonindigenous bacteria on the day of allogeneic hematopoietic stem cell transplantation. Invited Reviewed International journal

    Oku S, Takeshita T, Futatsuki T, Kageyama S, Asakawa M, Mori Y, Miyamoto T, Hata J, Ninomiya T, Kashiwazaki H, Yamashita Y

    PLoS Pathog   16   2020.3

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  • National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries. Invited Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC)(Ninomiya T, Hata J)

    Int J Epidemiol   49   173 - 192   2020.2

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  • Dietary inflammatory index positively associated with high-sensitivity C-reactive protein level in Japanese from NIPPON DATA2010. Invited Reviewed International journal

    Yang Y, Hozawa A, Kogure M, Narita A, Hirata T, Nakamura T, Tsuchiya N, Nakaya N, Ninomiya T, Okuda N, Kadota A, Ohkubo T, Okamura T, Ueshima H, Okayama A, Miura K

    J Epidemiol   30   98 - 107   2020.2

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  • Association between blood pressure variability and cerebral small-vessel disease: a systematic review and meta-analysis. Invited Reviewed International journal

    Tully PJ, Yano Y, Launer LJ, Kario K, Nagai M, Mooijaart SP, Claassen JAHR, Lattanzi S, Vincent AD, Tzourio C; Variability in Blood Pressure and Brain Health Consortium †; Variability in Blood Pressure and Brain Health Consortium (Ninomiya T, Ohara T, Oishi E)

    J Am Heart Assoc   9   e013841   2020.1

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  • Decline in handgrip strength from midlife to late-life is associated with dementia in a Japanese community: the Hisayama Study. Invited Reviewed International journal

    Hatabe Y, Shibata M, Ohara T, Oishi E, Yoshida D, Honda T, Hata J, Kanba S, Kitazono T, Ninomiya T

    J Epidemiol   30   15 - 23   2020.1

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  • Brachial-ankle pulse wave velocity versus its stiffness index β-transformed value as risk marker for cardiovascular disease. Invited Reviewed International journal

    Tomiyama H, Ohkuma T, Ninomiya T, Nakano H, Matsumoto C, Avolio A, Kohro T, Higashi Y, Maruhashi T, Takase B, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y,

    J Am Heart Assoc   8   e013004   2019.12

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  • Long-term regular exercise and intraocular pressure: the Hisayama Study. Invited Reviewed International journal

    Fujiwara K, Yasuda M, Hata J, Yoshida D, Kishimoto H, Hashimoto S, Yoshitomi T, Ninomiya T, Sonoda KH

    Graefes Arch Clin Exp Ophthalmol   257   2461 - 2469   2019.11

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  • Reduced Estimated GFR and Cardiac Remodeling: A Population-Based Autopsy Study. Invited Reviewed International journal

    Izumaru K, Hata J, Nakano T, Nakashima Y, Nagata M, Fukuhara M, Oda Y, Kitazono T, Ninomiya T

    Am J Kidney Dis.   74 ( 3 )   373 - 381   2019.11

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  • Serum elaidic acid concentration and risk of dementia: the Hisayama Study. Invited Reviewed International journal

    Honda T, Ohara T, Shinohara M, Hata J, Toh R, Yoshida D, Shibata M, Ishida T, Hirakawa Y, Irino Y, Sakata S, Uchida K, Kitazono T, Kanba S, Hirata KI, Ninomiya T

    Neurology   93   e2053 - e2064   2019.11

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  • Serum lipopolysaccharide-binding protein levels and the incidence of cardiovascular disease in a general Japanese population: the Hisayama Study. Invited Reviewed International journal

    Asada M, Oishi E, Sakata S, Hata J, Yoshida D, Honda T, Furuta Y, Shibata M, Suzuki K, Watanabe H, Murayama N, Kitazono T, Yamaura K, Ninomiya T

    J Am Heart Assoc   8 ( e013628 )   2019.11

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  • World health organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions. Invited Reviewed International journal

    WHO CVD Risk Chart Working Group (Hisayama: Ninomiya T, Hata J, Hirakawa Y)

    Lancet Glob Health   7   e1332 - e1345   2019.10

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  • Association between Axial Length and Myopic Maculopathy: The Hisayama Study. Invited Reviewed International journal

    Hashimoto S, Yasuda M, Fujiwara K, Ueda E, Hata J, Hirakawa Y, Ninomiya T, Sonoda KH

    Ophthalmol Retina   863 - 873   2019.10

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  • Estimation of nephron number in living humans by combining unenhanced computed tomography with biopsy-based stereology. Invited Reviewed International journal

    Sasaki T, Tsuboi N, Okabayashi Y, Haruhara K, Kanzaki G, Koike K, Kobayashi A, Yamamoto I, Takahashi S, Ninomiya T, Shimizu A, Rule AD, Bertram JF, Yokoo T

    Sci Rep   9   14400   2019.10

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  • Glucose Tolerance Levels and Circumpapillary Retinal Nerve Fiber Layer Thickness in a General Japanese Population: The Hisayama Study. Invited Reviewed International journal

    Fujiwara K, Yasuda M, Hata J, Hirakawa Y, Hashimoto S, Ueda E, Iwase A, Araie M, Yoshitomi T, Ninomiya T, Sonoda KH

    Am J Ophthalmol   140 - 146   2019.9

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  • NT-proBNP and risk of dementia in a general Japanese elderly population: the Hisayama Study. Invited Reviewed International journal

    Nagata T, Ohara T, Hata J, Sakata S, Furuta Y, Yoshida D, Honda T, Hirakawa Y, Ide T, Kanba S, Kitazono T, Tsutsui H, Ninomiya T

    J Am Heart Assoc 8: e011652, 2019   2019.9

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  • Association Between Serum β-Alanine and Risk of Dementia. Invited Reviewed International journal

    Hata J, Ohara T, Katakura Y, Shimizu K, Yamashita S, Yoshida D, Honda T, Hirakawa Y, Shibata M, Sakata S, Kitazono T, Kuhara S, Ninomiya T

    Am J Epidemiol   1637 - 1645   2019.9

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  • Characteristics of the Salivary Microbiota in Patients With Various Digestive Tract Cancers. Invited Reviewed International journal

    Kageyama S, Takeshita T, Takeuchi K, Asakawa M, Matsumi R, Furuta M, Shibata Y, Nagai K, Ikebe M, Morita M, Masuda M, Toh Y, Kiyohara Y, Ninomiya T, Yamashita Y

    Front Microbiol   1780 - 1789   2019.8

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  • Objectively measured sedentary time and diabetes mellitus in a general Japanese population: The Hisayama Study. Invited Reviewed International journal

    Honda T, Kishimoto H, Mukai N, Hata J, Yoshida D, Hirakawa Y, Shibata M, Ohara T, Kumagai S, Ninomiya T

    J Diabetes Investig   2019.8

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  • Association Between Genetic Risk and Development of Type 2 Diabetes in a General Japanese Population: The Hisayama Study. Invited Reviewed International journal

    Inaishi J, Hirakawa Y, Horikoshi M, Akiyama M, Higashioka M, Yoshinari M, Hata J, Mukai N, Kamatani Y, Momozawa Y, Kubo M, Ninomiya T

    J Clin Endocrinol Metab   3213 - 3222   2019.8

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  • Rising rural body-mass index is the main driver of the global obesity epidemic in adults. Invited Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC)(Hata J, Ninomiya T)

    Nature   260 - 264   2019.8

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  • Dietary sodium reduction reduces albuminuria: a cluster randomized trial. Invited Reviewed International journal

    Jardine MJ, Li N, Ninomiya T, Feng X, Zhang J, Shi J, Zhang Y, Zhang R, Zhang J, Hao J, Perkovic V, Heerspink HL, Wu Y, Yan LL, Neal B

    J Ren Nutr   29   276 - 284   2019.7

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  • Integrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid-β accumulation in Alzheimer's disease. Invited Reviewed International journal

    Yamaguchi-Kabata Y, Morihara T, Ohara T, Ninomiya T, Takahashi A, Akatsu H, Hashizume Y, Hayashi N, Shigemizu D, Boroevich KA, Ikeda M, Kubo M, Takeda M, Tsunoda T

    Hum Genet   137   521 - 533   2019.7

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  • Trends in the prevalence of type 2 diabetes and prediabetes in a Japanese community, 1988–2012: the Hisayama Study. Invited Reviewed International journal

    Mukai N, Hata J, Hirakawa Y, Ohara T, Yoshida D, Nakamura U, Kitazono T, Ninomiya T

    Diabetol Int   198 - 205   2019.7

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  • Trends in the prevalence of myopia and myopic maculopathy in a Japanese population: the Hisayama Study. Invited Reviewed International journal

    Ueda E, Yasuda M, Fujiwara K, Hashimoto S, Ohno-Matsui K, Hata J, Ishibashi T, Ninomiya T, Sonoda KH

    Invest Ophthalmol Vis Sci   2781 - 2786   2019.7

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  • Serum ethylamine levels as an indicator of L-theanine consumption and the risk of type 2 diabetes in a general Japanese population: the Hisayama Study. Invited Reviewed International journal

    Ninomiya T, Kanzaki N, Hirakawa Y, Yoshinari M, Higashioka M, Honda T, Shibata M, Sakata S, Yoshida D, Teramoto T, Takemoto S, Nishimoto S, Hata J, Kitazono T

    Diabetes Care 42: 1234-1240, 2019   1234 - 1240   2019.7

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  • Tauopathy in basal ganglia involvement is exacerbated in a subset of patients with Alzheimer's disease: the Hisayama study. Invited Reviewed International journal

    Hamasaki H, Honda H, Suzuki SO, Shijo M, Ohara T, Hatabe Y, Okamoto T, Ninomiya T, Iwaki T

    415 - 423   2019.6

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  • Secular trends in the incidence of end-stage renal disease and its risk factors in Japanese patients with immunoglobulin A nephropathy. Invited Reviewed International journal

    Tanaka S, Ninomiya T, Katafuchi R, Masutani K, Tsuchimoto A, Tokumoto M, Hirakata H, Ooboshi H, Kitazono T, Tsuruya K

    Nephrol Dial Transplant   33   963 - 971   2019.6

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  • Dairy consumption and risk of functional disability in an elderly Japanese population: the Hisayama Study. Invited Reviewed International journal

    Yoshida D, Ohara T, Hata J, Shibata M, Hirakawa Y, Honda T, Uchida K, Takasugi S, Kitazono T, Kiyohara Y, Ninomiya T

    Am J Clin Nutr   2019.6

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  • Periodontitis is associated with chronic obstructive pulmonary disease. Invited Reviewed International journal

    Takeuchi K, Matsumoto K, Furuta M, Fukuyama S, Takeshita T, Ogata H, Suma S, Shibata Y, Shimazaki Y, Hata J, Ninomiya T, Nakanishi Y, Inoue H, Yamashita Y

    J Dent Res   98   534 - 540   2019.5

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  • Association of extremely high levels of high-density lipoprotein cholesterol with cardiovascular mortality in a pooled analysis of 9 cohort studies including 43,407 individuals: The EPOCH-JAPAN study. Invited Reviewed International journal

    Hirata A, Sugiyama D, Watanabe M, Tamakoshi A, Iso H, Kotani K, Kiyama M, Yamada M, Ishikawa S, Murakami Y, Miura K, Ueshima H, Okamura T; Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH–JAPAN) Research Group (Ninomiya T, Kiyohara Y)

    J Clin Lipidol   12   674 - 684   2019.5

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  • Effect of SGLT2 inhibitors on cardiovascular, renal and safety outcomes in patients with type 2 diabetes mellitus and chronic kidney disease: A systematic review and meta-analysis. Invited Reviewed International journal

    Toyama T, Neuen BL, Jun M, Ohkuma T, Neal B, Jardine MJ, Heerspink HL, Wong MG, Ninomiya T, Wada T, Perkovic V

    Diabetes Obes Metab   1237 - 1250   2019.5

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  • Biomarkers of dietary omega-6 fatty acids and incident cardiovascular disease and mortality. Invited Reviewed International journal

    Marklund M, Wu JHY, Imamura F, Del Gobbo LC, Fretts A, de Goede J, Shi P, Tintle N, Wennberg M, Aslibekyan S, Chen TA, de Oliveira Otto MC, Hirakawa Y, Eriksen HH, Kröger J, Laguzzi F, Lankinen M, Murphy RA, Prem K, Samieri C, Virtanen J, Wood AC, Wong K,

    Circulation   139   2422 - 2436   2019.5

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  • Trends in the prevalence of airflow limitation in a general Japanese population: two serial cross-sectional surveys from the Hisayama Study. Invited Reviewed International journal

    Ogata H, Hirakawa Y, Matsumoto K, Hata J, Yoshida D, Fukuyama S, Inoue H, Kitazono T, Ninomiya T, Nakanishi Y

    BMJ Open   9   e023673   2019.3

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  • Steno-stiffness approach for cardiovascular disease risk assessment in primary prevention. Invited Reviewed International journal

    Tomiyama H, Ohkuma T, Ninomiya T, Mastumoto C, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Ito N, Nakamura M, Shoji T, Vlachopoulos C, Aboyans V, Yamashina A; Collaborative Group for J-BAVELs

    Hypertension   73   508 - 513   2019.3

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  • Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study. Invited Reviewed International journal

    Larsson SC, Traylor M, Burgess S, Boncoraglio GB, Jern C, Michaëlsson K, Markus HS; MEGASTROKE project of the International Stroke Genetics Consortium (Ninomiya T)

    Neurology   92   e944 - e950   2019.3

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  • Cardiovascular risk factors associated with venous thromboembolism. Invited Reviewed International journal

    Emerging Risk Factors Collaboration (Ninomiya T, Doi Y, Kiyohara Y)

    JAMA Cardiol   4   163 - 173   2019.2

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  • Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population: An individual participant data meta-analysis. Invited Reviewed International journal

    Ohkuma T, Ninomiya T, Tomiyama H, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Ito N, Nakamura M, Shoji T, Vlachopoulos C, Aboyans V, Yamashina A; collaborative group for the Japan Brachial-Ankle pulse wave VELocity individual participant data meta-analysis of prospective studies to examine the significance of the Ankle-Brachial Index (J-BAVEL-ABI)

    Atherosclerosis   275   141 - 148   2019.2

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  • Longitudinal changes of physical activity and sedentary time in the middle-aged and older Japanese population: the Hisayama Study. Invited Reviewed International journal

    Yonemoto K, Honda T, Kishimoto H, Yoshida D, Hata J, Mukai N, Shibata M, Hirakawa Y, Ninomiya T, Kumagai S

    J Phys Act Health   16   165 - 171   2019.2

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  • Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. Invited Reviewed International journal

    Ganesh Chauhan, et al., Ninomiya T

    Neurology   92   e486 - e503   2019.1

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  • Having few remaining teeth is associated with a low nutrient intake and low serum albumin levels in middle-aged and older Japanese individuals: findings from the NIPPON DATA2010. Invited Reviewed International journal

    Nakamura M, Ojima T, Nagahata T, Kondo I, Ninomiya T, Yoshita K, Arai Y, Ohkubo T, Murakami K, Nishi N, Murakami Y, Takashima N, Okuda N, Kadota A, Miyagawa N, Kondo K, Okamura T, Ueshima H, Okayama A, Miura K; NIPPON DATA2010 Research Group

    Environ Health Prev Med   24   1 - 9   2019.1

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  • Moyamoya disease susceptibility variant RNF213 p.R4810K increases the risk of ischemic stroke attributable to large-artery atherosclerosis. Invited Reviewed International journal

    Okazaki S, Morimoto T, Kamatani Y, Kamimura T, Kobayashi H, Harada K, Tomita T, Higashiyama A, Takahashi JC, Nakagawara J, Koga M, Toyoda K, Washida K, Saito S, Takahashi A, Hirata M, Matsuda K, Mochizuki H, Chong M, Paré G, O'Donnell M, Ago T, Hata J, Ninomiya T, Dichgans M, Debette S, Kubo M, Koizumi A, Ihara M

    Circulation   139   295 - 298   2019.1

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  • Apparent Treatment-Resistant Hypertension and Cardiovascular Risk in Hemodialysis Patients: Ten-Year Outcomes of the Q-Cohort Study. Invited Reviewed International journal

    Tanaka S, Ninomiya T, Hiyamuta H, Taniguchi M, Tokumoto M, Masutani K, Ooboshi H, Nakano T, Tsuruya K, Kitazono

    Sci Rep   9   1043 - 1050   2019.1

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  • Serum soluble triggering receptor expressed on myeloid cells 2 as a biomarker for incident dementia: the Hisayama Study. Invited Reviewed International journal

    Ohara T, Hata J, Tanaka M, Honda T, Yamakage H, Yoshida D, Inoue T, Hirakawa Y, Kusakabe T, Shibata M, Teraoka T, Kitazono T, Kanba S, Satoh-Asahara N, Ninomiya T

    Ann Neurol   85   47 - 58   2019.1

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    認知症のない久山町高齢住民約1,300名を10年間前向きに追跡し、血清sTREM2レベルと認知症発症の関係、および血清sTREM2が認知症発症の予測能に与える影響を検討した。その結果、血清sTREM2値の上昇に伴い、全認知症、アルツハイマー型認知症、および血管性認知症の発症リスクはいずれも有意に上昇することが判明した。さらに、既知の危険因子と血清sTREM2値を組み合わせることにより、将来の認知症発症の予測精度が有意に改善することを明らかにした。

  • Prevalence of adult epilepsy in a general Japanese population: the Hisayama study. Invited Reviewed International journal

    Tanaka A, Hata J, Akamatsu N, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Ohara T, Mizuno T, Tsuji S, Kitazono T, Ninomiya T

    Epilepsia Open   2019.1

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  • GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Invited Reviewed International journal

    MEGASTROKE Consortium (Ninomiya T, Hata J)

    Nat Commun   9   5141   2018.12

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  • Development and validation of modified risk prediction models for cardiovascular disease and its subtypes: the Hisayama Study. Invited Reviewed International journal

    Honda T, Yoshida D, Hata J, Hirakawa Y, Ishida Y, Shibata M, Sakata S, Kitazono T, Ninomiya T

    Atherosclerosis   279   38 - 44   2018.10

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    地域住民を対象とした疫学調査(久山町研究)の成績を用いて、心血管病リスク予測モデルを開発した。脳卒中のリスク予測モデルには、年齢、性別、収縮期血圧、糖尿病、喫煙習慣、運動習慣が、虚血性心疾患のリスク予測モデルには、、年齢、性別、収縮期血圧、糖尿病、HDLコレステロール、LDLコレステロール、喫煙習慣が有意な危険因子として選択された。各モデルにおいて、過剰適合は認められず、充分な識別能が確認された。

  • A potential novel pathological implication of serum soluble triggering receptor expressed on myeloid cell 2 in insulin resistance in a general Japanese population: the Hisayama Study. Reviewed International journal

    Tanaka M, Honda T, Yamakage H, Hata J, Yoshida D, Hirakawa Y, Shibata M, Inoue T, Kusakabe T, Satoh-Asahara N, Ninomiya T

    Diabetes Res Clin Pract   146   225 - 232   2018.10

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  • Association between daily sleep duration and risk of dementia and mortality in a Japanese community. Invited Reviewed International journal

    Ohara T, Honda T, Hata J, Yoshida D, Mukai N, Hirakawa Y, Shibata M, Kishimoto H, Kitazono T, Kanba S, Ninomiya T

    J Am Geriatr Soc   66   1911 - 1918   2018.10

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  • The association between blood pressure variability (BPV) with dementia and cognitive function: a systematic review and meta-analysis protocol. Invited Reviewed International journal

    VARIABLE BRAIN consortium( Ninomiya T, Ohara T, Oishi E)

    Syst Rev   7   163   2018.10

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  • Distribution of nephrologists and regional variation in the clinical severity of IgA nephropathy at biopsy diagnosis in Japan: a cross-sectional study. Invited Reviewed International journal

    Okabayashi Y, Tsuboi N, Amano H, Miyazaki Y, Kawamura T, Ogura M, Narita I, Ninomiya T, Yokoyama H, Yokoo T

    BMJ Open   8   e024317   2018.10

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  • Periodontal status and lung function decline in the community: the Hisayama Study. Invited Reviewed International journal

    Takeuchi K, Matsumoto K, Furuta M, Fukuyama S, Takeshita T, Ogata H, Suma S, Shibata Y, Shimazaki Y, Hata J, Ninomiya T, Nakanishi Y, Inoue H, Yamashita Y

    Sci Rep   8   13354   2018.9

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  • Estimated glomerular filtration rate decline and risk of end-stage renal disease in type 2 diabetes. Invited Reviewed International journal

    Oshima M, Toyama T, Haneda M, Furuichi K, Babazono T, Yokoyama H, Iseki K, Araki S, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Shimizu M, Hara A, Makino H, Wada T; Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan

    PLoS One   13   e0201535   2018.8

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  • Tongue microbiota and oral health status in community-dwelling elderly adults. Invited Reviewed International journal

    Asakawa M, Takeshita T, Furuta M, Kageyama S, Takeuchi K, Hata J, Ninomiya T, Yamashita Y

    mSphere   3   e00332 - -18   2018.8

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  • Prevalence and risk factors for polypoidal choroidal vasculopathy in a general Japanese population: the Hisayama Study. Invited Reviewed International journal

    Fujiwara K, Yasuda M, Hata J, Oshima Y, Hashimoto S, Yoshitomi T, Kiyohara Y, Ishibashi T, Ninomiya T, Sonoda KH

    Semin Ophthalmol   33 ( 6 )   813 - 819   2018.7

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  • Relationships among Food Group Intakes, Household Expenditure, and Education Attainment in a General Japanese Population: NIPPON DATA2010. Invited Reviewed International journal

    Nagahata T, Nakamura M, Ojima T, Kondo I, Ninomiya T, Yoshita K, Arai Y, Ohkubo T, Murakami K, Nishi N, Murakami Y, Takashima N, Okuda N, Kadota A, Miyagawa N, Kondo K, Okamura T, Ueshima H, Okayama A, Miura K

    J Epidemiol   28(Supplement_III)   S23 - S28   2018.7

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  • Socioeconomic Inequalities in Oral Health among Middle-Aged and Elderly Japanese: NIPPON DATA2010. Invited Reviewed International journal

    Murakami K, Ohkubo T, Nakamura M, Ninomiya T, Ojima T, Shirai K, Nagahata T, Kadota A, Okuda N, Nishi N, Okamura T, Ueshima H, Okayama A, Miura K

    J Epidemiol   28(Supplement_III)   S59 - S65   2018.7

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  • Association between the ratio of serum arachidonic acid to eicosapentaenoic acid and the presence of depressive symptoms in a general Japanese population: the Hisayama Study. Invited Reviewed International journal

    Shibata M, Ohara T, Yoshida D, Hata J, Mukai N, Kawano H, Kanba S, Kitazono T, Ninomiya T

    J Affect Disord   237   73 - 79   2018.7

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  • Secular trends in the incidence of end-stage renal disease and its risk factors in Japanese patients with immunoglobulin A nephropathy. Invited Reviewed International journal

    Tanaka S, Ninomiya T, Katafuchi R, Masutani K, Tsuchimoto A, Tokumoto M, Hirakata H, Ooboshi H, Kitazono T, Tsuruya K

    Nephrol Dial Transplant   33   963 - 971   2018.6

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  • Secular trends in the incidence, risk factors, and prognosis of transient ischemic attack in Japan: The Hisayama Study. Invited Reviewed International journal

    Furuta Y, Hata J, Mukai N, Hirakawa Y, Ago T, Kitazono T, Kiyohara Y, Ninomiya T

    Atherosclerosis   273   84 - 90   2018.6

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  • Simultaneously Measured Interarm Blood Pressure Difference and Stroke: An Individual Participants Data Meta-Analysis. Invited Reviewed International journal

    Tomiyama H, Ohkuma T, Ninomiya T, Mastumoto C, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Ito N, Nakamura M, Shoji T, Vlachopoulos C, Yamashina A; collaborative group for J-BA

    Hypertension   71   1030 - 1038   2018.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community. Invited Reviewed International journal

    Yubi T, Hata J, Ohara T, Mukai N, Hirakawa Y, Yoshida D, Gotoh S, Hirabayashi N, Furuta Y, Ago T, Kitazono T, Kiyohara Y, Ninomiya T

    Neurology: Clinical Practice   8   223 - 231   2018.6

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  • Association of extremely high levels of high-density lipoprotein cholesterol with cardiovascular mortality in a pooled analysis of 9 cohort studies including 43,407 individuals: The EPOCH-JAPAN study. Invited Reviewed International journal

    Hirata A, Sugiyama D, Watanabe M, Tamakoshi A, Iso H, Kotani K, Kiyama M, Yamada M, Ishikawa S, Murakami Y, Miura K, Ueshima H, Okamura T; Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH–JAPAN) Research Group (Ninomiya T,Kiyohara Y)

    J Clin Lipidol   12   674 - 684   2018.5

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  • Development and validation of a risk assessment tool for gastric cancer in a general Japanese population. Invited Reviewed International journal

    Iida M, Ikeda F, Hata J, Hirakawa Y, Ohara T, Mukai N, Yoshida D, Yonemoto K, Esaki M, Kitazono T, Kiyohara Y, Ninomiya T

    Gastric Cancer   21   383 - -390   2018.5

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  • Patterns and Levels of Sedentary Behavior and Physical Activity in a General Japanese Population: The Hisayama Study. Invited Reviewed International journal

    Chen T, Kishimoto H, Honda T, Hata J, Yoshida D, Mukai N, Shibata M, Ninomiya T, Kumagai S

    J Epidemiol   28   260 - 265   2018.5

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  • Clustering of risk factors and the risk of incident cardiovascular disease in Asian and Caucasian populations: results from the Asia Pacific Cohort Studies Collaboration. Invited Reviewed International journal

    Peters SAE, Wang X, Lam TH, Kim HC, Ho S, Ninomiya T, Knuiman M, Vaartjes I, Bots ML, Woodward M; Asia Pacific Cohort Studies Collaboration (Hisayama: Ninomiya T, Hata J, Hirakawa Y)

    BMJ Open   8: e019335,   2018.5

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  • Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Invited Reviewed International journal

    MEGASTROKE Consortium( Ninomiya T, Hata J)

    50   524 - 537   2018.4

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  • Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi. Invited Reviewed International journal

    Shijo M, Honda H, Suzuki SO, Hamasaki H, Hokama M, Abolhassani N, Nakabeppu Y, Ninomiya T, Kitazono T, Iwaki T

    Brain Pathol   28   58 - 71   2018.1

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  • Albuminuria increases the risks for both Alzheimer disease and vascular dementia in community-dwelling Japanese elderly: the Hisayama Study. Invited Reviewed International journal

    Takae K, Hata J, Ohara T, Yoshida D, Shibata M, Mukai N, Hirakawa Y, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T

    J Am Heart Assoc 7: e006693, 2018   7   e006693   2018.1

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  • Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation. Invited Reviewed International journal

    Castillo E, Leon J, Mazzei G, Abolhassani N, Haruyama N, Saito T, Saido T, Hokama M, Iwaki T, Ohara T, Ninomiya T, Kiyohara Y, Sakumi K, LaFerla FM, Nakabeppu Y

    Sci Rep   7   17762 - 17762   2017.12

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  • The ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cancer death in a Japanese community: the Hisayama Study. Invited Reviewed International journal

    Nagata M, Hata J, Hirakawa Y, Mukai N, Yoshida D, Ohara T, Kishimoto H, Kawano H, Kitazono T, Kiyohara Y, Ninomiya T

    J Epidemiol   27   578 - 583   2017.12

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  • Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Invited Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC)(Nimoniya T)

    Lancet   390   2627 - 2642   2017.11

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  • White-coat and masked hypertension are associated with albuminuria in a general population: the Hisayama Study. Invited Reviewed International journal

    Hata J, Fukuhara M, Sakata S, Arima H, Hirakawa Y, Yonemoto K, Mukai N, Kitazono T, Kiyohara Y, Ninomiya T

    Hypertens Res   40   937 - 943   2017.11

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  • Exploration of bacterial species associated with the salivary microbiome of individuals with a low susceptibility to dental caries. Invited Reviewed International journal

    Yasunaga H, Takeshita T, Shibata Y, Furuta M, Shimazaki Y, Akifusa S, Ninomiya T, Kiyohara Y, Takahashi I, Yamashita Y

    21   2399 - 2406   2017.11

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  • Impact of blood urea nitrogen to creatinine ratio on mortality and morbidity in hemodialysis patients: The Q-Cohort Study. Invited Reviewed International journal

    Tanaka S, Ninomiya T, Taniguchi M, Tokumoto M, Masutani K, Ooboshi H, Kitazono T, Tsuruya K

    Sci Rep   7   14901 - 14909   2017.11

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  • Association of airflow limitation with carotid atherosclerosis in a Japanese community - the Hisayama Study. Invited Reviewed International journal

    Kudo K, Hata J, Matsumoto K, Shundo Y, Fukuyama S, Inoue H, Kitazono T, Kiyohara Y, Ninomiya T, Nakanishi Y

    Circ J   81   1846 - 1853   2017.11

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  • Author response: Trends in dementia prevalence, incidence, and survival rate in a Japanese community. Invited Reviewed International journal

    Ohara T, Ninomiya T

    Neurology   89   1930 - 1931   2017.10

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  • Morning and evening blood pressures are associated with intima-media thickness in a general population - the Hisayama Study. Invited Reviewed International journal

    Sakata S, Hata J, Fukuhara M, Yonemoto K, Mukai N, Yoshida D, Kishimoto H, Ohtsubo T, Kitazono T, Kiyohara Y, Ninomiya T

    Circ J   81   1647 - 1653   2017.10

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  • Proposed cutoff value of brachial-ankle pulse wave velocity for the management of hypertension. Invited Reviewed International journal

    Ohkuma T, Tomiyama H, Ninomiya T, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Ito N, Nakamura M, Shoji T, Vlachopoulos C, Yamashina A; Collaborative Group for Japan Brachial-An

    Circ J   81   1540 - 1542   2017.9

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  • Erratum to "Characteristics and prognosis of Japanese colorectal cancer patients: The BioBank Japan Project" [J Epidemiol 27(3S) (2017) S36-S42]. Invited Reviewed International journal

    Tamakoshi A, Nakamura K, Ukawa S, Okada E, Hirata M, Nagai A, Matsuda K, Kamatani Y, Muto K, Kiyohara Y, Yamagata Z, Ninomiya T, Kubo M, Nakamura Y; BioBank Japan Cooperative Hospital Group

    J Epidemiol   27   398 - 399   2017.8

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  • Day-to-day blood pressure variability and risk of dementia in a general Japanese elderly population: the Hisayama Study. Invited Reviewed International journal

    Oishi E, Ohara T, Sakata S, Fukuhara M, Hata J, Yoshida D, Shibata M, Ohtsubo T, Kitazono T, Kiyohara Y, Ninomiya T

    Circulation   136   516 - 525   2017.8

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  • Association between serum vitamin D and all-cause and cause-specific death in a general Japanese population - the Hisayama Study. Invited Reviewed International journal

    Umehara K, Mukai N, Hata J, Hirakawa Y, Ohara T, Yoshida D, Kishimoto H, Kitazono T, Hoka S, Kiyohara Y, Ninomiya T

    Circ J   81 ( 9 )   1315 - 1321   2017.8

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  • Alternative measures of hyperglycemia and risk of alzheimer's disease in the community: the Hisayama Study. Invited Reviewed International journal

    Mukai N, Ohara T, Hata J, Hirakawa Y, Yoshida D, Kishimoto H, Koga M, Nakamura U, Kitazono T, Kiyohara Y, Ninomiya T

    J Clin Endocrinol Metab   102 ( 8 )   3002 - 3010   2017.8

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  • Serum non-high-density lipoprotein cholesterol and risk of cardiovascular disease in community dwellers with chronic kidney disease: the Hisayama Study. Invited Reviewed International journal

    Usui T, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Kitazono T, Kiyohara Y, Ninomiya T

    J Atheroscler Thromb   24   706 - 715   2017.7

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  • Chronic kidney disease in Asia: Protocol for a collaborative overview. Invited Reviewed International journal

    Liyanage T, Ninomiya T, Perkovic V, Woodward M, Stirnadel-Farrant H, Matsushita K, Iseki K, Seong HL, Monaghan H, Jha V

    Nephrology (Carlton)   22 ( 6 )   456 - 462   2017.6

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  • Brachial-ankle pulse wave velocity and the risk prediction of cardiovascular disease: an individual oarticipant data meta-analysis. Invited Reviewed International journal

    Ohkuma T, Ninomiya T, Tomiyama H, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Ito N, Nakamura M, Shoji T, Vlachopoulos C, Yamashina A; Collaborative Group for J-BAVEL

    Hypertension   69   1045 - 1052   2017.6

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  • The contribution of inflammation to the development of hypertension mediated by increased arterial stiffness. Invited Reviewed International journal

    Tomiyama H, Shiina K, Matsumoto-Nakano C, Ninomiya T, Komatsu S, Kimura K, Chikamori T, Yamashina A

    J Am Heart Assoc   6   e005729   2017.6

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  • The Fukuoka Kidney disease Registry (FKR) Study: design and methods. Invited Reviewed International journal

    Tanaka S, Ninomiya T, Fujisaki K, Yoshida H, Nagata M, Masutani K, Tokumoto M, Mitsuiki K, Hirakata H, Fujimi S, Kiyohara Y, Kitazono T, Tsuruya K; Fukuoka Kidney disease Registry (FKR) Study Collaboration Group

    Clin Exp Nephrol   21 ( 3 )   465 - 473   2017.6

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  • Trends in dementia prevalence, incidence, and survival rate in a Japanese community. Invited Reviewed International journal

    Ohara T, Hata J, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y, Ninomiya T

    Neurology   88   1925 - 1932   2017.5

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  • Tooth loss and risk of dementia in the community: the Hisayama Study. Invited Reviewed International journal

    Takeuchi K, Ohara T, Furuta M, Takeshita T, Shibata Y, Hata J, Yoshida D, Yamashita Y, Ninomiya T

    J Am Geriatr Soc   65   e95 - e100   2017.5

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  • Development of a self-scored persistent airflow obstruction screening questionnaire in a general Japanese population: the Hisayama Study. Invited Reviewed International journal

    Ozawa M, Yoshida D, Hata J, Ohara T, Mukai N, Shibata M, Uchida K, Nagata M, Kitazono T, Kiyohara Y, Ninomiya T

    Int J Chron Obstruct Pulmon Dis   12   1469 - 1481   2017.5

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  • Risk prediction models for mortality in patients with cardiovascular disease: The BioBank Japan project. Invited Reviewed International journal

    Hata J, Nagai A, Hirata M, Kamatani Y, Tamakoshi A, Yamagata Z, Muto K, Matsuda K, Kubo M, Nakamura Y; Biobank Japan Cooperative Hospital Group., Kiyohara Y, Ninomiya T; Collaborator

    J Epidemiol   27 ( 3s )   S71 - S76   2017.3

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  • Overview of BioBank Japan follow-up data in 32 diseases. Invited Reviewed International journal

    Hirata M, Nagai A, Kamatani Y, Ninomiya T, Tamakoshi A, Yamagata Z, Kubo M, Muto K, Kiyohara Y, Mushiroda T, Murakami Y, Yuji K, Furukawa Y, Zembutsu H, Tanaka T, Ohnishi Y, Nakamura Y; BioBank Japan Cooperative Hospital Group., Matsuda K

    J Epidemiol   27 ( 3s )   S22 - S28   2017.3

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  • Cross-sectional analysis of BioBank Japan clinical data: A large cohort of 200,000 patients with 47 common diseases. Invited Reviewed International journal

    Hirata M, Kamatani Y, Nagai A, Kiyohara Y, Ninomiya T, Tamakoshi A, Yamagata Z, Kubo M, Muto K, Mushiroda T, Murakami Y, Yuji K, Furukawa Y, Zembutsu H, Tanaka T, Ohnishi Y, Nakamura Y; BioBank Japan Cooperative Hospital Group., Matsuda K

    J Epidemiol   27 ( 3s )   S9 - S21   2017.3

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  • Age-specific impact of diabetes mellitus on the risk of cardiovascular mortality: An overview from the evidence for Cardiovascular Prevention from Observational Cohorts in the Japan Research Group (EPOCH-JAPAN). Invited Reviewed International journal

    Hirakawa Y, Ninomiya T, Kiyohara Y, Murakami Y, Saitoh S, Nakagawa H, Okayama A, Tamakoshi A, Sakata K, Miura K, Ueshima H, Okamura T; Evidence for Cardiovascular Prevention From Observational Cohorts in Japan Research Group (EPOCH-JAPAN)

    J Epidemiol   27 ( 3 )   123 - 129   2017.3

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  • Characteristics and prognosis of Japanese female breast cancer patients: The BioBank Japan project. Invited Reviewed International journal

    Nakamura K, Okada E, Ukawa S, Hirata M, Nagai A, Yamagata Z, Kiyohara Y, Muto K, Kamatani Y, Ninomiya T, Matsuda K, Kubo M, Nakamura Y; BioBank Japan Cooperative Hospital Group., Tamakoshi A

    J Epidemiol   27 ( 3 )   S58 - S64   2017.3

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  • Characteristics of patients with liver cancer in the BioBank Japan project. Invited Reviewed International journal

    Ukawa S, Okada E, Nakamura K, Hirata M, Nagai A, Matsuda K, Yamagata Z, Kamatani Y, Ninomiya T, Kiyohara Y, Muto K, Kubo M, Nakamura Y; BioBank Japan Cooperative Hospital Group., Tamakoshi A

    J Epidemiol   27 ( 3s )   S43 - S48   2017.3

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  • Survival of macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking in patients with type 2 diabetes: BioBank Japan cohort. Invited Reviewed International journal

    Yokomichi H, Nagai A, Hirata M, Kiyohara Y, Muto K, Ninomiya T, Matsuda K, Kamatani Y, Tamakoshi A, Kubo M, Nakamura Y; BioBank Japan Cooperative Hospital Group., Yamagata Z

    J Epidemiol   27 ( 3s )   S98 - S106   2017.3

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  • Characteristics and prognosis of Japanese male and female lung cancer patients: The BioBank Japan Project. Invited Reviewed International journal

    Nakamura K, Ukawa S, Okada E, Hirata M, Nagai A, Yamagata Z, Ninomiya T, Muto K, Kiyohara Y, Matsuda K, Kamatani Y, Kubo M, Nakamura Y; BioBank Japan Cooperative Hospital Group., Tamakoshi A

    J Epidemiol   27 ( 3s )   S49 - S57   2017.3

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  • Demographic and lifestyle factors and survival among patients with esophageal and gastric cancer: The Biobank Japan Project. Invited Reviewed International journal

    Okada E, Ukawa S, Nakamura K, Hirata M, Nagai A, Matsuda K, Ninomiya T, Kiyohara Y, Muto K, Kamatani Y, Yamagata Z, Kubo M, Nakamura Y; BioBank Japan Cooperative Hospital Group., Tamakoshi A

    J Epidemiol   27 ( 3s )   S29 - S35   2017.3

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  • Overview of the BioBank Japan Project: Study design and profile. Invited Reviewed International journal

    Nagai A, Hirata M, Kamatani Y, Muto K, Matsuda K, Kiyohara Y, Ninomiya T, Tamakoshi A, Yamagata Z, Mushiroda T, Murakami Y, Yuji K, Furukawa Y, Zembutsu H, Tanaka T, Ohnishi Y, Nakamura Y; BioBank Japan Cooperative Hospital Group., Kubo M

    J Epidemiol   27 ( 3s )   S2 - S8   2017.3

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  • Serum glucose, cholesterol and blood pressure levels in Japanese type 1 and 2 diabetic patients: BioBank Japan. Invited Reviewed International journal

    Yokomichi H, Nagai A, Hirata M, Kiyohara Y, Muto K, Ninomiya T, Matsuda K, Kamatani Y, Tamakoshi A, Kubo M, Nakamura Y; BioBank Japan Cooperative Hospital Group., Yamagata Z

    J Epidemiol   27 ( 3s )   S92 - S97   2017.3

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  • Statin use and all-cause and cancer mortality: BioBank Japan cohort. Invited Reviewed International journal

    Yokomichi H, Nagai A, Hirata M, Tamakoshi A, Kiyohara Y, Kamatani Y, Muto K, Ninomiya T, Matsuda K, Kubo M, Nakamura Y; BioBank Japan Cooperative Hospital Group., Yamagata Z

    J Epidemiol   27 ( 3s )   S84 - S91   2017.3

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  • Clinical and histopathological characteristics of patients with prostate cancer in the BioBank Japan project. Invited Reviewed International journal

    Ukawa S, Nakamura K, Okada E, Hirata M, Nagai A, Yamagata Z, Muto K, Matsuda K, Ninomiya T, Kiyohara Y, Kamatani Y, Kubo M, Nakamura Y; BioBank Japan Cooperative Hospital Group., Tamakoshi A

    J Epidemiol   27   S65 - S70   2017.3

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  • Stimulated salivary flow rate and oral health status. Invited Reviewed International journal

    Shimazaki Y, Fu B, Yonemoto K, Akifusa S, Shibata Y, Takeshita T, Ninomiya T, Kiyohara Y, Yamashita Y

    J Oral Sci   59 ( 1 )   55 - 62   2017.3

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  • Characteristics and prognosis of Japanese colorectal cancer patients: The BioBank Japan Project. Invited Reviewed International journal

    Tamakoshi A, Nakamura K, Ukawa S, Okada E, Hirata M, Nagai A, Matsuda K, Kamatani Y, Muto K, Kiyohara Y, Yamagata Z, Ninomiya T, Kubo M, Nakamura Y; BioBank Japan Cooperative Hospital Group

    J Epidemiol   27 ( 3s )   S36 - S42   2017.3

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  • Cholesterol levels of Japanese dyslipidaemic patients with various comorbidities: BioBank Japan. Invited Reviewed International journal

    Yokomichi H, Noda H, Nagai A, Hirata M, Tamakoshi A, Kamatani Y, Kiyohara Y, Matsuda K, Muto K, Ninomiya T, Kubo M, Nakamura Y; BioBank Japan Cooperative Hospital Group., Yamagata Z

    J Epidemiol   27 ( 3s )   S77 - S83   2017.3

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  • Genetic predisposition to ischemic stroke: a polygenic risk score. Invited Reviewed International journal

    Hachiya T, Kamatani Y, Takahashi A, Hata J, Furukawa R, Shiwa Y, Yamaji T, Hara M, Tanno K, Ohmomo H, Ono K, Takashima N, Matsuda K, Wakai K, Sawada N, Iwasaki M, Yamagishi K, Ago T, Ninomiya T, Fukushima A, Hozawa A, Minegishi N, Satoh M, Endo R, Sasaki

    Stroke   48 ( 2 )   253 - 258   2017.2

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  • Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants. Invited Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC) (Ninomiya T)

    Lancet   389   37 - 55   2017.1

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  • Combination of Helicobacter pylori Antibody and Serum Pepsinogen as a Good Predictive Tool of Gastric Cancer Incidence: 20-Year Prospective Data From the Hisayama Study. Invited Reviewed International journal

    Ikeda F, Shikata K, Hata J, Fukuhara M, Hirakawa Y, Ohara T, Mukai N, Nagata M, Yoshida D, Yonemoto K, Esaki M, Kitazono T, Kiyohara Y, Ninomiya T

    J Epidemiol   26 ( 12 )   629 - 636   2016.12

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  • Association Between Diabetes and Hippocampal Atrophy in Elderly Japanese: the Hisayama Study. Invited Reviewed International journal

    Hirabayashi N, Hata J, Ohara T, Mukai N, Nagata M, Shibata M, Gotoh S, Furuta Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Kiyohara Y, Ninomiya T

    Diabetes Care   39 ( 9 )   1543 - 1549   2016.9

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  • Serum Angiopoietin-Like Protein 2 Is a Novel Risk Factor for Cardiovascular Disease in the Community: the Hisayama Study. Invited Reviewed International journal

    Hata J, Mukai N, Nagata M, Ohara T, Yoshida D, Kishimoto H, Shibata M, Hirakawa Y, Endo M, Ago T, Kitazono T, Oike Y, Kiyohara Y, Ninomiya T

    Arterioscler Thromb Vasc Biol   36 ( 8 )   1686 - 1691   2016.8

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  • Effects of the Mediterranean Diet on Cardiovascular Outcomes-A Systematic Review and Meta-Analysis. Invited Reviewed International journal

    Liyanage T, Ninomiya T, Wang A, Neal B, Jun M, Wong MG, Jardine M, Hillis GS, Perkovic V.

    PLoS One   11 ( 8 )   2016.8

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  • Comparison of the COPD Population Screener and International Primary Care Airway Group questionnaires in a general Japanese population: the Hisayama study. Invited Reviewed International journal

    Tsukuya G, Samukawa T, Matsumoto K, Fukuyama S, Kumamoto T, Uchida A, Koriyama C, Ninomiya T, Inoue H

    Int J Chron Obstruct Pulmon Dis   11 ( 8 )   1903 - 1909   2016.8

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  • Interventions for lowering plasma homocysteine levels in kidney transplant recipients. Invited Reviewed International journal

    Kang A, Nigwekar SU, Perkovic V, Kulshrestha S, Zoungas S, Navaneethan SD, Cass A, Gallagher MP, Ninomiy T, Strippoli GF, Jardine MJ

    Cochrane Database Syst Rev   5   2016.8

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  • A century of trends in adult human height Invited Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC) (Ninomiya T, Hata J)

    Elife. 2016 Jul 26;5:e13410.   2016.7

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  • Serum Uric Acid as a Risk Factor for Chronic Kidney Disease in a Japanese Community - the Hisayama Study -. Invited Reviewed International journal

    Takae K, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T

    Circ J   80 ( 8 )   1857 - 1862   2016.7

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  • Perceived inadequate care and excessive overprotection during childhood are associated with greater risk of sleep disturbance in adulthood: the Hisayama Study. Invited Reviewed International journal

    Shibata M, Ninomiya T, Anno K, Kawata H, Iwaki R, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M

    BMC Psychiatry   16   215   2016.7

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  • Foveal and Macular Thickness in a Japanese Population: the Hisayama Study. Invited Reviewed International journal

    Hashimoto S, Yasuda M, Ninomiya T, Hata J, Yoshida D, Tahara-Asakuma T, Hirakawa Y, Arakawa S, Fujiwara K, Kiyohara Y, Ishibashi T

    Ophthalmic Epidemiol   23   202 - 208   2016.6

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  • Admission Heart Rate Predicts Poor Outcomes in Acute Intracerebral Hemorrhage: The Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial Studies. Invited Reviewed International journal

    Qiu M, Sato S, Zheng D, Wang X, Carcel C, Hirakawa Y, Sandset EC, Delcourt C, Arima H, Wang J, Chalmers J, Anderson CS; INTERACT Investigators

    Stroke   47 ( 6 )   1479 - 1485   2016.6

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  • Renin-angiotensin system inhibitors and kidney and cardiovascular outcomes in patients with CKD: a Bayesian network meta-analysis of randomized clinical trials. Invited Reviewed International journal

    Xie X, Liu Y, Perkovic V, Li X, Ninomiya T, Hou W, Zhao N, Liu L, Lv J, Zhang H, Wang H

    Am J Kidney Dis   2016.5

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  • Trends in autopsy-verified dementia prevalence over 29 years of the Hisayama study. Invited Reviewed International journal

    Honda H, Sasaki K, Hamasaki H, Shijo M, Koyama S, Ohara T, Ninomiya T, Kiyohara Y, Suzuki SO, Iwaki T

    Neuropathology   2016.5

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  • Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. Invited Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC) (Hata J, Ninomiya T)

    Lancet   387   1513 - 1530   2016.4

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  • Risks associated with permanent discontinuation of blood pressure-lowering medications in patients with type 2 diabetes. Invited Reviewed International journal

    Hirakawa Y, Arima H, Webster R, Zoungas S, Li Q, Harrap S, Lisheng L, Hamet P, Mancia G, Poulter N, Neal B, Williams B, Rogers A, Woodward M, Chalmers J

    J Hypertens   34 ( 4 )   781 - 787   2016.4

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  • Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants. Invited Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC) (Kiyohara Y, Ninomiya T)

    Lancet   387   1377 - 1396   2016.4

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  • The long-term association between physical activity and risk of dementia in the community: the Hisayama Study. Invited Reviewed International journal

    Kishimoto H, Ohara T, Hata J, Ninomiya T, Yoshida D, Mukai N, Nagata M, Ikeda F, Fukuhara M, Kumagai S, Kanba S, Kitazono T, Kiyohara Y

    Eur J Epidemiol   2016.3

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  • Recent Increases in Hippocampal Tau Pathology in the Aging Japanese Population: the Hisayama Study. Invited Reviewed International journal

    Hamasaki H, Honda H, Okamoto T, Koyama S, Suzuki SO, Ohara T, Ninomiya T, Kiyohara Y, Iwaki T

    J Alzheimers Dis   55 ( 2 )   613 - 624   2016.2

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  • Is a reduction in albuminuria associated with renal and cardiovascular protection? A post-hoc analysis of the ALTITUDE trial. Invited Reviewed International journal

    Lambers Heerspink HJ, Ninomiya T, Persson F, Brenner BM, Brunel P, Chaturvedi N, Desai AS, Haffner SM, Mcmurray JJ, Solomon SD, Pfeffer MA, Parving HH, de Zeeuw D

    Diabetes Obes Metab   18   169 - 77   2016.2

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  • Bacterial diversity in saliva and oral health-related conditions: the Hisayama Study. Invited Reviewed International journal

    Takeshita T, Kageyama S, Furuta M, Tsuboi H, Takeuchi K, Shibata Y, Shimazaki Y, Akifusa S, Ninomiya T, Kiyohara Y, Yamashita Y

    Sci Rep   2016.2

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  • Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia. Invited Reviewed International journal

    Chatterjee S, Peters SA, Woodward M, Mejia Arango S, Batty GD, Beckett N, Beiser A, Borenstein AR, Crane PK, Haan M, Hassing LB, Hayden KM, Kiyohara Y, Larson EB, Li CY, Ninomiya T, Ohara T, Peters R, Russ TC, Seshadri S, Strand BH, Walker R, Xu W, Huxley RR

    Diabetes Care   39   300 - 307   2016.2

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  • Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis. Invited Reviewed International journal

    Xie X, Atkins E, Lv J, Bennett A, Neal B, Ninomiya T, Woodward M, MacMahon S, Turnbull F, Hillis GS, Chalmers J, Mant J, Salam A, Rahimi K, Perkovic V, Rodgers A

    Lancet   387   435 - 443   2016.1

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  • Prognostic impact of serum bilirubin level on long-term renal survival in IgA nephropathy. Invited Reviewed International journal

    Tanaka S, Ninomiya T, Masutani K, Nagata M, Tsuchimoto A, Tsuruya K, Kitazono T

    Clin Exp Nephrol   19   1062 - 1070   2015.12

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  • Insulin Resistance Is a Risk Factor for Increased Intraocular Pressure: The Hisayama Study. Invited Reviewed International journal

    Fujiwara K, Yasuda M, Ninomiya T, Hata J, Hashimoto S, Yoshitomi T, Kiyohara Y, Ishibashi T

    Invest Ophthalmol Vis Sci   56   7983 - 7987   2015.12

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  • The effect of renin-angiotensin system blockade on the incidence of end-stage renal disease in IgA nephropathy. Invited Reviewed International journal

    Tanaka S, Ninomiya T, Katafuchi R, Masutani K, Nagata M, Tsuchimoto A, Hirakata H, Kitazono T, Tsuruya K

    Clin Exp Nephrol   2015.11

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  • Midlife and Late-Life Smoking and Risk of Dementia in the Community: The Hisayama Study. Invited Reviewed International journal

    Ohara T, Ninomiya T, Hata J, Ozawa M, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y

    J Am Geriatr Soc   63   2332 - 2339   2015.11

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  • Association between eating rate and obesity: a systematic review and meta-analysis. Invited Reviewed International journal

    Ohkuma T, Hirakawa Y, Nakamura U, Kiyohara Y, Kitazono T, Ninomiya T.

    Int J Obes (Lond)   39   1589 - 1596   2015.11

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  • Angiotensin I-converting enzyme gene polymorphism enhances the effect of hypercholesterolemia on the risk of coronary heart disease in a general Japanese population: the Hisayama Study. Invited Reviewed International journal

    Kondo H, Ninomiya T, Hata J, Hirakawa Y, Yonemoto K, Arima H, Nagata M, Tsuruya K, Kitazono T, Kiyohara Y

    J Atheroscler Thromb   22   390 - 403   2015.10

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  • Hematocrit and the risk of cardiovascular disease in a Japanese community: the Hisayama Study Invited Reviewed International journal

    Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Ago T, Kitazono T, Kiyohara Y

    Atherosclerosis   242   199 - 204   2015.9

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  • Serum antibody to Porphyromonas gingivalis and periodontitis progression: the Hisayama Study. Invited Reviewed International journal

    Takeuchi K, Furuta M, Takeshita T, Shibata Y, Shimazaki Y, Akifusa S, Ninomiya T, Kiyohara Y, Yamashita Y

    J Clin Periodontol   42   719 - 725   2015.8

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  • Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331,288 participants. Invited Reviewed International journal

    NCD Risk Factor Collaboration (Ninomiya T)

    Lancet Diabetes Endocrinol   8   624 - 637   2015.8

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  • A genome-wide association study of late-onset Alzheimer's disease in a Japanese population. Invited Reviewed International journal

    Hirano A, Ohara T, Takahashi A, Aoki M, Fuyuno Y, Ashikawa K, Morihara T, Takeda M, Kamino K, Oshima E, Okahisa Y, Shibata N, Arai H, Akatsu H, Ikeda M, Iwata N, Ninomiya T, Monji A, Kitazono T, Kiyohara Y, Kubo M, Kanba S

    Psychiatr Genet   25   139 - 146   2015.8

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  • Paternal and maternal bonding styles in childhood are associated with the prevalence of chronic pain in a general adult population: the Hisayama Study. Invited Reviewed International journal

    Anno K, Shibata M, Ninomiya T, Iwaki R, Kawata H, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M

    BMC Psychiatry   15   181 - 181   2015.7

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  • Health-related quality of life in survivors of acute kidney injury: the Prolonged Outcomes Study of the Randomized Evaluation of Normal versus Augmented Level Replacement Therapy study outcomes. Invited Reviewed International journal

    Wang AY, Bellomo R, Cass A, Finfer S, Gattas D, Myburgh J, Chadban S, Hirakawa Y, Ninomiya T, Li Q, Lo S, Barzi F, Sukkar L, Jardine M, Gallagher MP; POST-RENAL Study Investigators and the ANZICS Clinical Trials Group:

    Nephrology (Carlton)   20   492 - 498   2015.7

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  • Association of hemoglobin A1c and glycated albumin with carotid atherosclerosis in community-dwelling Japanese subjects: the Hisayama Study. Invited Reviewed International journal

    Mukai N, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y

    Cardiovasc Diabetol   14   84 - 84   2015.6

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  • Worldwide access to treatment for end-stage kidney disease: a systematic review Reviewed International journal

    Liyanage T, Ninomiya T (Double first author), Jha V, Neal B, Patrice HM, Okpechi I, Zhao MH, Lv J, Garg AX, Knight J, Rodgers A, Gallagher M, Kotwal S, Cass A, Perkovic V

    Lancet   6736   61601 - 61609   2015.5

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    世界199か国のうち、123か国の腎代替療法を受けている患者数のデータを収集し、全世界の腎代替療法をうけている患者数を推計した。その結果、全世界で腎代替療法を受けている患者数(2010年) は、2.62 百万人 と推定された。そのうち、約60%は国民総所得の高い国で行われており、低所得の国ではと治療を受けられずに亡くなっていることが示唆された。さらに、腎代替療法を受ける患者数の将来推計を行った結果、今後アジア地区での患者数が増大することが予測された。

  • Hyporesponsiveness to erythropoiesis-stimulating agent as a prognostic factor in Japanese hemodialysis patients: the Q-Cohort study. International journal

    Eriguchi R, Taniguchi M, Ninomiya T, Hirakata H, Fujimi S, Tsuruya K, Kitazono T

    J Nephrol   28   217 - 225   2015.4

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  • Risk factors for reduced salivary flow rate in a Japanese population: the Hisayama study International journal

    Takeuchi K, Furuta M, Takeshita T, Shibata Y, Shimazaki Y, Akifusa S, Ninomiya T, Kiyohara Y, Yamashita Y.

    Biomed Res Int   381821   2015.2

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  • Hisayama Pulmonary Physiology Study Group. International journal

    Tsukuya G, Matsumoto K, Fukuyama S, Crawford B, Nakanishi Y, Ichinose M, Machida K, Samukawa T, Ninomiya T, Kiyohara Y, Inoue H

    Allergol Int   64   49 - 53   2015.1

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  • Dietary patterns and clinical outcomes in hemodialysis patients in Japan: a cohort study. International journal

    Tsuruya K, Fukuma S, Wakita T, Ninomiya T, Nagata M, Yoshida H, Fujimi S, Kiyohara Y, Kitazono T, Uchida K, Shirota T, Akizawa T, Akiba T, Saito A, Fukuhara S.

    PLoS One   21 ( 10(1) )   e0116677   2015.1

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  • Distinct composition of the oral indigenous microbiota in South Korean and Japanese adults. Invited Reviewed International journal

    Takeshita T, Matsuo K, Furuta M, Shibata Y, Fukami K, Shimazaki Y, Akifusa S, Han DH, Kim HD, Yokoyama T, Ninomiya T, Kiyohara Y, Yamashita Y.

    Sci Rep   4   6990   2014.11

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  • Angiotensin-converting enzyme inhibitor usage and acute kidney injury: a secondary analysis of RENAL study outcomes Reviewed International journal

    Wang AY, Bellomo R, Ninomiya T, Lo S, Cass A, Jardine M, Gallagher M; RENAL Study Investigators; ANZICS Clinical Trials Group

    Nephrology (Carlton)   19   617 - 622   2014.10

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  • Altered expression of diabetes-related genes in Alzheimer's disease brains: the Hisayama Study. Invited Reviewed International journal

    Hokama M, Oka S, Leon J, Ninomiya T, Honda H, Sasaki K, Iwaki T, Ohara T, Sasaki T, Laferla FM, Kiyohara Y, Nakabeppu Y.

    Cereb Cortex   24   2476 - 2488   2014.9

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  • Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment. Invited Reviewed International journal

    Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (Doi Y, Hata J, Kiyohara Y, Ninomiya T).

    Lancet Diabetes Endocrinol   2   634 - 647   2014.8

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  • Impact of visit-to-visit glycemic variability on the risks of macrovascular and microvascular events and all-cause mortality in type 2 diabetes: the ADVANCE Trial. Invited Reviewed International journal

    Hirakawa Y, Arima H, Zoungas S, Ninomiya T, Cooper M, Hamet P, Mancia G, Poulter N, Harrap S, Woodward M, Chalmers J

    Diabetes Care   2014.8

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  • Milk and dairy consumption and risk of dementia in an elderly Japanese population: the hisayama study Reviewed International journal

    Ozawa M, Ohara T, Ninomiya T, Hata J, Yoshida D, Mukai N, Nagata M, Uchida K, Shirota T, Kitazono T, Kiyohara Y

    J Am Geriatr Soc   62   1224 - 1230   2014.7

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  • Midlife and late-life handgrip strength and risk of cause-specific death in a general Japanese population: the Hisayama Study Reviewed International journal

    Kishimoto H, Hata J, Ninomiya T, Nemeth H, Hirakawa Y, Yoshida D, Kumagai S, Kitazono T, Kiyohara Y

    J Epidemiol Community Health   68   663 - 668   2014.7

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  • The Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan. Clinical impact of albuminuria and glomerular filtration rate on renal and cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes. Invited Reviewed International journal

    Wada T, Haneda M, Furuichi K, Babazono T, Yokoyama H, Iseki K, Araki SI, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Shimizu M, Toyama T, Hara A, Makino H

    Clin Exp Nephrol   18   621 - 622   2014.6

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  • Effect of hemodiafiltration or hemofiltration compared with hemodialysis on mortality and cardiovascular disease in chronic kidney failure: a systematic review and meta-analysis of randomized trials Reviewed International journal

    Wang AY, Ninomiya T, Al-Kahwa A, Perkovic V, Gallagher MP, Hawley C, Jardine MJ

    Am J Kidney Dis   63   968 - 978   2014.6

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  • A Low Ankle Brachial Index is Associated with an Increased Risk of Cardiovascular Disease: The Hisayama Study Reviewed International journal

    Kojima I, Ninomiya T, Hata J, Fukuhara M, Hirakawa Y, Mukai N, Yoshida D, Kitazono T, Kiyohara Y

    J Atheroscler Thromb   21   966 - 973   2014.4

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  • Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population: the Hisayama Study Reviewed International journal

    Imamura T, Doi Y, Ninomiya T, Hata J, Nagata M, Ikeda F, Mukai N, Hirakawa Y, Yoshida D, Fukuhara M, Kitazono T, Kiyohara Y

    Atherosclerosis   233   343 - 348   2014.4

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  • Glycated hemoglobin measurement and prediction of cardiovascular disease. Invited Reviewed International journal

    Emerging Risk Factors Collaboration (Kiyohara Y, Arima H, Ninomiya T, Hata J).

    JAMA   311   1225 - 1233   2014.3

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  • The construction of risk prediction models using GWAS data and its application to a type 2 diabetes prospective cohort. Invited Reviewed International journal

    Shigemizu D, Abe T, Morizono T, Johnson TA, Boroevich KA, Hirakawa Y, Ninomiya T, Kiyohara Y, Kubo M, Nakamura Y, Maeda S, Tsunoda T

    PLoS One   20   e92549   2014.3

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  • Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants. Invited Reviewed International journal

    Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (BMI Mediated Effects)(Hata J, Kiyohara Y, Ninomiya T), Lu Y, Hajifathalian K, Ezzati M, Woodward M, Rimm EB, Danaei G.

    Lancet   383   970 - 983   2014.3

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  • Assessing risk prediction models using individual participant data from multiple studies. Invited Reviewed International journal

    Pennells L, Kaptoge S, White IR, Thompson SG, Wood AM; Emerging Risk Factors Collaboration (Kiyohara Y, Arima H, Doi Y, Ninomiya T).

    Am J Epidemiol   179   621 - 632   2014.3

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  • Trends in the prevalence of type 2 diabetes and prediabetes in community-dwelling Japanese subjects: The Hisayama Study Reviewed International journal

    Mukai N, Doi Y, Ninomiya T, Hirakawa Y, Nagata M, Yoshida D, Hata J, Fukuhara M, Nakamura U, Kitazono T, Kiyohara Y

    J Diabetes Investig   5   162 - 169   2014.3

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  • Alexithymia is associated with greater risk of chronic pain and negative affect and with lower life satisfaction in a general population: the Hisayama Study Reviewed International journal

    Shibata M, Ninomiya T, Jensen MP, Anno K, Yonemoto K, Makino S, Iwaki R, Yamashiro K, Yoshida T, Imada Y, Kubo C, Kiyohara Y, Sudo N, Hosoi M

    PLoS One   12   2014.3

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  • Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression. Invited Reviewed International journal

    Horio E, Kadomatsu T, Miyata K, Arai Y, Hosokawa K, Doi Y, Ninomiya T, Horiguchi H, Endo M, Tabata M, Tazume H, Tian Z, Takahashi O, Terada K, Takeya M, Hao H, Hirose N, Minami T, Suda T, Kiyohara Y, Ogawa H, Kaikita K, Oike Y

    Arterioscler Thromb Vasc Biol   34   790 - 800   2014.2

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  • ABCD3 and ABCD3-I Scores Are Superior to ABCD2 Score in the Prediction of Short- and Long-Term Risks of Stroke After Transient Ischemic Attack. Invited Reviewed International journal

    Kiyohara T, Kamouchi M, Kumai Y, Ninomiya T, Hata J, Yoshimura S, Ago T, Okada Y, Kitazono T; for the FSR investigators; Fukuoka Stroke Registry Investigators

    Stroke   45   418 - 425   2014.2

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  • Thresholds of various glycemic measures for diagnosing diabetes based on prevalence of retinopathy in community-dwelling Japanese subjects: the Hisayama Study Reviewed International journal

    Mukai N, Yasuda M, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y

    Cardiovasc Diabetol   13   2014.2

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  • Serum 1,25-Dihydroxyvitamin D and the Development of Kidney Dysfunction in a Japanese Community Reviewed International journal

    Izumaru K, Ninomiya T, Nagata M, Usui T, Yoshida D, Yonemoto K, Fukuhara M, Tsuruya K, Kitazono T, Kiyohara Y

    Circ J 2014   78   732 - 737   2014.1

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  • Trends in the incidence and survival of intracerebral hemorrhage by its location in a Japanese community Reviewed International journal

    Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Shikata K, Kamouchi M, Kitazono T, Kiyohara Y

    Circ J   78   403 - 409   2014.1

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  • Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: the Hisayama Study Reviewed International journal

    Ninomiya T, Nagata M, Hata J, Hirakawa Y, Ozawa M, Yoshida D, Ohara T, Kishimoto H, Mukai N, Fukuhara M, Kitazono T, Kiyohara Y

    Atherosclerosis   231   261 - 267   2013.12

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  • Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general Japanese population: the Hisayama Study Reviewed International journal

    Ikeda F, Doi Y, Ninomiya T, Hirakawa Y, Mukai N, Hata J, Shikata K, Yoshida D, Matsumoto T, Kitazono T, Kiyohara Y

    Cardiovasc Diabetol   12   2013.11

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  • HLA-A2, HLA-B44 and HLA-DR15 are associated with lower risk of BK viremia Reviewed International journal

    Masutani K, Ninomiya T, Randhawa P

    Nephrol Dial Transplant   28   3119 - 3126   2013.11

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  • Development and validation of a prediction rule using the Oxford classification in IgA nephropathy Reviewed International journal

    Tanaka S, Ninomiya T, Katafuchi R, Masutani K, Tsuchimoto A, Noguchi H, Hirakata H, Tsuruya K, Kitazono T

    Clin J Am Soc Nephrol   8   2082 - 2090   2013.11

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  • Blood pressure lowering and major cardiovascular events in people with and without chronic kidney disease: meta-analysis of randomised controlled trials Reviewed International journal

    Ninomiya T, Perkovic V, Turnbull F, Neal B, Barzi F, Cass A, Baigent C, Chalmers J, Li N, Woodward M, MacMahon S; Blood Pressure Lowering Treatment Trialists’ Collaboration

    BMJ   347   2013.10

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  • Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: a cross-sectional study Reviewed International journal

    Sekita A, Arima H, Ninomiya T, Ohara T, Doi Y, Hirakawa Y, Fukuhara M, Hata J, Yonemoto K, Ga Y, Kitazono T, Kanba S, Kiyohara Y

    BMC Public Health   13   2013.9

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  • Secular trends in cardiovascular disease and its risk factors in Japanese: half century data from the Hisayama Study Reviewed International journal

    Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y

    Circulation   128   1198 - 1205   2013.9

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  • Gender differences in the association between metabolic syndrome and periodontal disease: the Hisayama Study. Invited Reviewed International journal

    Furuta M, Shimazaki Y, Takeshita T, Shibata Y, Akifusa S, Eshima N, Kiyohara Y, Ninomiya T, Hirakawa Y, Mukai N, Nagata M, Yamashita Y

    J Clin Periodontol   40   743 - 752   2013.8

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  • Effects of intensive blood pressure lowering on the progression of chronic kidney disease: a systematic review and meta-analysis. Invited Reviewed International journal

    Lv J, Ehteshami P, Sarnak MJ, Tighiouart H, Jun M, Ninomiya T, Foote C, Rodgers A, Hong Z, Wang H, Strippoli GF, Perkovic V

    CMAJ   185   949 - 957   2013.8

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  • The impacts of albuminuria and low eGFR on the risk of cardiovascular death, all-cause mortality, and renal events in diabetic patients: meta-analysis Reviewed International journal

    Toyama T, Furuichi K, Ninomiya T, Shimizu M, Hara A, Iwata Y, Kaneko S, Wada T

    PLoS One   8   2013.8

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  • Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders: results from the Hisayama Study Reviewed International journal

    Nakano T, Ninomiya T, Sumiyoshi S, Onimaru M, Fujii H, Itabe H, Nakashima Y, Sueishi K, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y

    Kidney Int   84   373 - 380   2013.8

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  • Prediction of cardiovascular disease mortality by proteinuria and reduced kidney function: pooled analysis of 39,000 individuals from 7 cohort stu dies in Japan Reviewed International journal

    Nagata M, Ninomiya T, Kiyohara Y, Murakami Y, Irie F, Sairenchi T, Miura K, Okamura T, Ueshima H

    Am J Epidemiol   178   1 - 11   2013.7

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  • Angiopoietin-like protein 2 is associated with chronic kidney disease in a general Japanese population Reviewed International journal

    Usui T, Ninomiya T, Nagata M, Takahashi O, Doi Y, Hata J, Fukuhara M, Kitazono T, Oike Y, Kiyohara Y

    Circ J   77   2311 - 2317   2013.6

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  • White-coat and masked hypertension are associated with carotid atherosclerosis in a general population: the Hisayama Study Reviewed International journal

    Fukuhara M, Arima H, Ninomiya T, Hata J, Hirakawa Y, Doi Y, Yonemoto K, Mukai N, Nagata M, Ikeda F, Matsumura K, Kitazono T, Kiyohara Y

    Stroke   44   1512 - 1517   2013.6

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  • Temporal trends in sudden unexpected death in a general population: the Hisayama Study Reviewed International journal

    Nagata M, Ninomiya T, Doi Y, Hata J, Ikeda F, Mukai N, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y

    Am Heart J   165   932 - 938   2013.6

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  • The global cardiovascular risk transition: associations of four metabolic risk factors with national income, urbanization, and Western diet in 1980 and 2008. Invited Reviewed International journal

    Danaei G, Singh GM, Paciorek CJ, Lin JK, Cowan MJ, Finucane MM, Farzadfar F, Stevens GA, Riley LM, Lu Y, Rao M, Ezzati M; Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group(Ninomiya T)

    Circulation   127   1493 - 1502   2013.4

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  • Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009 and 2010. Invited Reviewed International journal

    Sugiyama H, Yokoyama H, Sato H, Saito T, Kohda Y, Nishi S, Tsuruya K, Kiyomoto H, Iida H, Sasaki T, Higuchi M, Hattori M, Oka K, Kagami S, Kawamura T, Takeda T, Hataya H, Fukasawa Y, Fukatsu A, Morozumi K, Yoshikawa N, Shimizu A, Kitamura H, Yuzawa Y, Matsuo S, Kiyohara Y, Joh K, Nagata M, Taguchi T, Makino H,Committee for Standardization of Renal Pathological Diagnosis; Committee for Kidney Disease Registry(Ninomiya T); Japanese Society of Nephrology

    Clin Exp Nephrol 17: 155-173, 2013   17   155 - 173   2013.4

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  • Association Study of 71 European Crohn's Disease Susceptibility Loci in a Japanese Population. Invited Reviewed International journal

    Hirano A, Yamazaki K, Umeno J, Ashikawa K, Aoki M, Matsumoto T, Nakamura S, Ninomiya T, Matsui T, Hirai F, Kawaguchi T, Takazoe M, Tanaka H, Motoya S, Kiyohara Y, Kitazono T, Nakamura Y, Kamatani N, Kubo M

    Inflamm Bowel Dis 19: 526-533, 2013   19   526 - 533   2013.3

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  • ADVANCE Collaborative Group: Effects of the endpoint adjudication process on the results of a randomised controlled trial: the ADVANCE trial. Invited Reviewed International journal

    Hata J, Arima H, Zoungas S, Fulcher G, Pollock C, Adams M, Watson J, Joshi R, Kengne AP, Ninomiya T, Anderson C, Woodward M, Patel A, Mancia G, Poulter N, MacMahon S, Chalmers J, Neal B

    PLoS One 8: e55807, 2013   8   e55807   2013.2

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  • Impact of eating rate on obesity and cardiovascular risk factors according to glucose tolerance status: the Fukuoka Diabetes Registry and the Hisayama Study. Invited Reviewed International journal

    Ohkuma T, Fujii H, Iwase M, Kikuchi Y, Ogata S, Idewaki Y, Ide H, Doi Y, Hirakawa Y, Mukai N, Ninomiya T, Uchida K, Nakamura U, Sasaki S, Kiyohara Y, Kitazono T

    Diabetologia   56   70 - 77   2013.1

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  • Angiopoietin-Like Protein 2 and Risk of Type 2 Diabetes in a General Japanese Population: the Hisayama Study. Invited Reviewed International journal

    Doi Y, Ninomiya T, Hirakawa Y, Takahashi O, Mukai N, Hata J, Iwase M, Kitazono T, Oike Y, Kiyohara Y

    Diabetes Care   36   98 - 100   2013.1

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  • Committee for the Standardization of Renal Pathological Diagnosis and for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology(Ninomiya T), and the Progressive Renal Disease Research of the Ministry of Health, Labour and Welfare of Japan: Renal disease in the elderly and the very elderly Japanese: analysis of the Japan Renal Biopsy Registry (J-RBR). Invited Reviewed International journal

    Yokoyama H, Sugiyama H, Sato H, Taguchi T, Nagata M, Matsuo S, Makino H, Watanabe T, Saito T, Kiyohara Y, Nishi S, Iida H, Morozumi K, Fukatsu A, Sasaki T, Tsuruya K, Kohda Y, Higuchi M, Kiyomoto H, Goto S, Hattori M, Hataya H, Kagami S, Yoshikawa N, Fukasawa Y, Ueda Y, Kitamura H, Shimizu A, Oka K, Nakagawa N, Ito T, Uchida S, Furuichi K, Nakaya I, Umemura S, Hiromura K, Yoshimura M, Hirawa N, Shigematsu T, Fukagawa M, Hiramatsu M, Terada Y, Uemura O, Kawata T, Matsunaga A, Kuroki A, Mori Y, Mitsuiki K, Yoshida H

    Clin Exp Nephrol   16   903 - 920   2012.12

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  • the ADVANCE Collaborative Group: Prediction of kidney-related outcomes in patients with type 2 diabetes. Invited Reviewed International journal

    Jardine MJ, Hata J, Woodward M, Perkovic V, Ninomiya T, Arima H, Zoungas S, Cass A, Patel A, Marre M, Mancia G, Mogensen CE, Poulter N, Chalmers J

    Am J Kidney Dis   60   770 - 778   2012.11

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  • C-reactive protein, fibrinogen, and cardiovascular disease prediction. Invited Reviewed International journal

    Emerging Risk Factors Collaboration(Ninomiya T), Kaptoge S, Di Angelantonio E, Pennells L, Wood AM, White IR, Gao P, Walker M, Thompson A, Sarwar N, Caslake M, Butterworth AS, Amouyel P, Assmann G, Bakker SJ, Barr EL, Barrett-Connor E, Benjamin EJ, Björkelund C, Brenner H, Brunner E, Clarke R, Cooper JA, Cremer P, Cushman M, Dagenais GR, D'Agostino RB Sr, Dankner R, Davey-Smith G, Deeg D, Dekker JM, Engström G, Folsom AR, Fowkes FG, Gallacher J, Gaziano JM, Giampaoli S, Gillum RF, Hofman A, Howard BV, Ingelsson E, Iso H, Jørgensen T, Kiechl S, Kitamura A, Kiyohara Y, Koenig W, Kromhout D, Kuller LH, Lawlor DA, Meade TW, Nissinen A, Nordestgaard BG, Onat A, Panagiotakos DB, Psaty BM, Rodriguez B, Rosengren A, Salomaa V, Kauhanen J, Salonen JT, Shaffer JA, Shea S, Ford I, Stehouwer CD, Strandberg TE, Tipping RW, Tosetto A, Wassertheil-Smoller S, Wennberg P, Westendorp RG, Whincup PH, Wilhelmsen L, Woodward M, Lowe GD, Wareham NJ, Khaw KT, Sattar N, Packard CJ, Gudnason V, Ridker PM, Pepys MB, Thompson SG, Danesh J

    N Engl J Med   367   1310 - 1320   2012.10

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  • Antioxidants for chronic kidney disease. Invited Reviewed International journal

    Jun M, Venkataraman V, Razavian M, Cooper B, Zoungas S, Ninomiya T, Webster AC, Perkovic V

    Cochrane Database Syst Rev   10   2012.10

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  • Resting heart rate and the risk of death and cardiovascular complications in patients with type 2 diabetes mellitus. Invited Reviewed International journal

    Hillis GS, Woodward M, Rodgers A, Chow CK, Li Q, Zoungas S, Patel A, Webster R, Batty GD, Ninomiya T, Mancia G, Poulter NR, Chalmers J

    Diabetologia   55   1283 - 1290   2012.10

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  • Prevalence and risk factors for myopic retinopathy in a Japanese population: the Hisayama Study. Invited Reviewed International journal

    Asakuma T, Yasuda M, Ninomiya T, Noda Y, Arakawa S, Hashimoto S, Ohno-Matsui K, Kiyohara Y, Ishibashi T

    Ophthalmology   119   1760 - 1765   2012.9

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  • Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: a systematic review and meta-analysis. Invited Reviewed International journal

    Lv J, Neal B, Ehteshami P, Ninomiya T, Woodward M, Rodgers A, Wang H, Macmahon S, Turnbull F, Hillis G, Chalmers J, Perkovic V

    PLoS Med   9   e1001293   2012.8

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  • Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis. Invited Reviewed International journal

    Emerging Risk Factors Collaboration(Ninomiya T)

    Int J Epidemiol   41   1419 - 1433   2012.7

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  • Insulin resistance and the development of cardiovascular disease in a Japanese community: the Hisayama Study. Invited Reviewed International journal

    Gotoh S, Doi Y, Hata J, Ninomiya T, Mukai N, Fukuhara M, Kamouchi M, Kitazono T, Kiyohara Y

    J Atheroscler Thromb   19   977 - 985   2012.7

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  • Putative episodes of T-cell-mediated rejection in patients with sustained BK viruria but no viremia. Invited Reviewed International journal

    Masutani K, Shapiro R, Basu A, Tan H, Ninomiya T, Randhawa P

    Transplantation   94   43 - 49   2012.7

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  • The effect of folic acid based homocysteine lowering on cardiovascular events in people with kidney disease: systematic review and meta-analysis. Invited Reviewed International journal

    Jardine MJ, Kang A, Zoungas S, Navaneethan SD, Ninomiya T, Nigwekar SU, Gallagher MP, Cass A, Strippoli G, Perkovic V

    BMJ   344   3533   2012.6

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  • Optimal cutoff value of the serum pepsinogen level for prediction of gastric cancer incidence: the Hisayama Study Reviewed International journal

    Shikata K, Ninomiya T, Yonemoto K, Ikeda F, Hata J, Doi Y, Fukuhara M, Matsumoto T, Iida M, Kitazono T, Kiyohara Y

    Scand J Gastroenterol   47   2012.6

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  • Impact of lower range of prehypertension on cardiovascular events in a general population: the Hisayama Study Reviewed International journal

    Fukuhara M, Arima H, Ninomiya T, Hata J, Yonemoto K, Doi Y, Hirakawa Y, Matsumura K, Kitazono T, Kiyohara Y

    J Hypertens   30   2012.5

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Association of HbA(1c) levels with vascular complications and death in patients with type 2 diabetes: evidence of glycaemic thresholds. Reviewed International journal

    Zoungas S, Chalmers J, Ninomiya T, Li Q, Cooper ME, Colagiuri S, Fulcher G, de Galan BE, Harrap S, Hamet P, Heller S, Macmahon S, Marre M, Poulter N, Travert F, Patel A, Neal B, Woodward M; for the ADVANCE Collaborative Group

    Diabetologia   55   2012.3

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    Language:English   Publishing type:Research paper (scientific journal)  

  • White blood cell count and risk of gastric cancer incidence in a general Japanese population: the Hisayama study. Reviewed International journal

    Iida M, Ikeda F, Ninomiya T, Yonemoto K, Doi Y, Hata J, Matsumoto T, Iida M, Kiyohara Y

    Am J Epidemiol   175   2012.3

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  • Cut-off values of fasting and post-load plasma glucose and HbA1c for predicting Type 2 diabetes in community-dwelling Japanese subjects: the Hisayama Study Reviewed International journal

    Mukai N, Doi Y, Ninomiya T, Hata J, Hirakawa Y, Fukuhara M, Iwase M, Kiyohara Y

    Diabet Med   29   2012.1

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  • Two risk score models for 2 diabetes in Japan. Reviewed International journal

    Doi Y, Ninomiya T, Hata J, Hirakawa Y, Mukai N, Iwase M, Kiyohara Y

    Diabet Med   29   2012.1

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  • Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. A collaborative meta-analysis of kidney disease population cohorts. Invited Reviewed International journal

    Chronic Kidney Disease Prognosis Consortium(Ninomiya T), Astor BC, Matsushita K, Gansevoort RT, van der Velde M, Woodward M, Levey AS, de Jong PE, Coresh J, El-Nahas M, Eckardt KU, Kasiske BL, Wright J, Appel L, Greene T, Levin A, Djurdjev O, Wheeler DC, Landray MJ, Townend JN, Emberson J, Clark LE, Macleod A, Marks A, Ali T, Fluck N, Prescott G, Smith DH, Weinstein JR, Johnson ES, Thorp ML, Wetzels JF, Blankestijn PJ, van Zuilen AD, Menon V, Sarnak M, Beck G, Kronenberg F, Kollerits B, Froissart M, Stengel B, Metzger M, Remuzzi G, Ruggenenti P, Perna A, Heerspink HJ, Brenner B, de Zeeuw D, Rossing P, Parving HH, Auguste P, Veldhuis K, Wang Y, Camarata L, Thomas B, Manley T

    Kidney Int   79   1331 - 1340   2011.12

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  • Validation study of oxford classification of IgA nephropathy: the significance of extracapillary proliferation Reviewed International journal

    Katafuchi R, Ninomiya T, Nagata M, Mitsuiki K, Hirakata H

    Clin J Am Soc Nephrol   6   2011.12

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  • N-Terminal Pro-Brain Natriuretic Peptide and Risk of Cardiovascular Events in a Japanese Community: The Hisayama Study. Reviewed International journal

    Doi Y, Ninomiya T, Hata J, Hirakawa Y, Mukai N, Ikeda F, Fukuhara M, Iwase M, Kiyohara Y

    Arterioscler Thromb Vasc Biol   31   2011.12

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  • Association of Alzheimer disease pathology with abnormal lipid metabolism: the Hisayama Study. Invited Reviewed International journal

    Matsuzaki T, Sasaki K, Hata J, Hirakawa Y, Fujimi K, Ninomiya T, Suzuki SO, Kanba S, Kiyohara Y, Iwaki T

    Neurology   77   1068 - 1075   2011.9

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  • Glucose tolerance status and risk of dementia in the community: The Hisayama Study Reviewed International journal

    Ohara T, Doi Y, Ninomiya T, Hirakawa Y, Hata J, Iwaki T, Kanba S, Kiyohara Y

    Neurology   77   2011.9

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  • Japan Renal Biopsy Registry: the first nationwide, web-based, and prospective registry system of renal biopsies in Japan. Invited Reviewed International journal

    Sugiyama H, Yokoyama H, Sato H, Saito T, Kohda Y, Nishi S, Tsuruya K, Kiyomoto H, Iida H, Sasaki T, Higuchi M, Hattori M, Oka K, Kagami S, Nagata M, Kawamura T, Honda M, Fukasawa Y, Fukatsu A, Morozumi K, Yoshikawa N, Yuzawa Y, Matsuo S, Kiyohara Y, Joh K, Taguchi T, Makino H; Committee for Standardization of Renal Pathological Diagnosis and Working Group for Renal Biopsy Database, Japanese Society of Nephrology, Tokyo, Japan (Ninomiya T).

    Clin Exp Nephrol   15   493 - 503   2011.8

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  • Nine-year incidence and risk factors for retinal vein occlusion in a general Japanese population: the Hisayama Study. Invited Reviewed International journal

    Arakawa S, Yasuda M, Nagata M, Ninomiya T, Hirakawa Y, Doi Y, Kiyohara Y, Ishibashi T

    Invest Ophthalmol Vis Sci   52   5905 - 5909   2011.7

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  • High serum bilirubin levels and diabetic retinopathy: the Hisayama Study. Invited Reviewed International journal

    Yasuda M, Kiyohara Y, Wang JJ, Arakawa S, Yonemoto K, Doi Y, Ninomiya T, Ishibashi T

    Ophthalmology   118   1423 - 1428   2011.6

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  • Dietary vitamin A intake and incidence of gastric cancer in a general Japanese population: the Hisayama Study. Invited Reviewed International journal

    Miyazaki M, Doi Y, Ikeda F, Ninomiya T, Hata J, Uchida K, Shirota T, Matsumoto T, Iida M, Kiyohara Y

    Gastric Cancer   15   162 - 169   2011.4

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  • Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies. Invited Reviewed International journal

    Wormser D, Kaptoge S, Di Angelantonio E, Wood AM, Pennells L, Thompson A, Sarwar N, Kizer JR, Lawlor DA, Nordestgaard BG, Ridker P, Salomaa V, Stevens J, Woodward M, Sattar N, Collins R, Thompson SG, Whitlock G, Danesh J; the Emerging Risk Factors Collaboration(Ninomiya T)

    Lancet   377   1085 - 1095   2011.3

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Diabetes mellitus, fasting glucose, and risk of cause-specific death. Invited Reviewed International journal

    Seshasai SR, Kaptoge S, Thompson A, Di Angelantonio E, Gao P, Sarwar N, Whincup PH, Mukamal KJ, Gillum RF, Holme I, Njølstad I, Fletcher A, Nilsson P, Lewington S, Collins R, Gudnason V, Thompson SG, Sattar N, Selvin E, Hu FB, Danesh J; the Emerging Risk Factors Collaboration(Ninomiya T)

    N Engl J Med   364   829 - 841   2011.3

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  • National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years and 5.4 million participants. Invited Reviewed International journal

    Danaei G, Finucane MM, Lin JK, Singh GM, Paciorek CJ, Cowan MJ, Farzadfar F, Stevens GA, Lim SS, Riley LM, Ezzati M; Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Blood Pressure) (Ninomiya T)

    Lancet   377   568 - 577   2011.2

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    Language:English   Publishing type:Research paper (scientific journal)  

  • 逆浸透装置膜圧の処理水エンドトキシン濃度に及ぼす影響. Invited Reviewed International journal

    小野 健一, 久保 充明, 利田 忠陽, 二宮 利治, 柏木 稔, 平方 恵理子, 金井 英俊, 平方 秀樹, 藤見 惺

    日本透析医学会雑誌   35   281 - 286   2002.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Treatment of hepatic encephalopathy by retrograde transcaval coil embolization of an ileal vein-to-right gonadal vein portosystemic shunt. Reviewed International journal

    Nishie A, Yoshimitsu K, Honda H, Kaneko K, Kuroiwa T, Fukuya T, Irie H, Ninomiya T, Yoshimitsu T, Hirakata H, Okuda S, Masuda K.

    Cardiovasc Intervent Radiol   20 ( 3 )   222 - 224   1997.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s002709900142

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Books

  • Renal and microalbuminuria data from ADVANCE: Role of Macro and Microcirculation in Target Organ Damage in Diabetes and Hypertension.

    Perkovic V, Ninomiya T, MacMahon S, Chalmers J.(Role:Joint author)

    2009.1 

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    Responsible for pages:Chapter 9 Editors: Lévy BI and Struijker-Houdier HAJ Publishers : Wiley-Blackwell, Wiley and Sons, Oxford, UK, 2009.   Language:English   Book type:Scholarly book

  • 冠動脈疾患の疫学 -久山町研究-. 冠動脈疾患の予防戦略.

    二宮 利治, 清原 裕.(Role:Edit)

    2008.1 

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    Responsible for pages:代田 浩之(編), 中山書店, 東京, 17-19, 2006   Language:Japanese   Book type:Scholarly book

  • ロコモ・フレイル予防のお手軽レシピ

    二宮 利治, 木村 安美

    大道学館出版部  2023 

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    Total pages:38  

    CiNii Research

  • ≪精神医学の基盤≫[6]精神医学を基礎づける疫学研究と臨床研究 総合テーマ 精神医学における科学的基盤3.

    二宮利治

    2022.12 

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    Responsible for pages:古川壽亮, 川上憲人(編), 山脇成人, 神庭重信(監), (株)学樹書院, 東東京都, pp58-69, 2022   Language:Japanese  

  • 循環器病予防エビデンスブックVol.1. 三浦克之, 大久保孝義(編), 医歯薬出版(株), 東京都, pp8-18, 2021

    秦 淳、二宮利治

    医歯薬出版(株), 東京都,  2021.6 

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    Responsible for pages:pp8-18, 2021   Language:English  

  • Chapter2. Epidemiological evidence of the relationship between diabetes and dementia. Diabetes Mellitus A risk factor for Alzheimer's Disease, Nakabeppu Y, Ninomiya T(Editors),

    Ninomiya T(Role:Joint author)

    Springer  2019.8 

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    Responsible for pages:pp13-25   Language:Japanese   Book type:Scholarly book

  • Chapter6. Epidemiology of dementia in a community: the Hisayama Study.

    Ninomiya T

    Health Issues and Care System for the Elderly, Washio M, Kiyohara C(editors),Springer  2019.2 

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    Responsible for pages:pp83-95   Language:Japanese  

  • Diet and nutrition in dementia and cognitive decline: Japanese perspective on dietary patterns and risk of dementia

    Ninomiya T, Ozawa M(Role:Joint author)

    2015.1 

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    Responsible for pages:Chapter 26. Editors: Martin CR and Preedy VR, Publishers: Academic Press, Oxford, UK, 2015   Language:English   Book type:Scholarly book

  • Brain, Stroke and Kidney (Contributions to Nephrology, Vol. 179): Risk of stroke in kidney disease

    Ninomiya T(Role:Sole author)

    2013.1 

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    Responsible for pages:Editors Toyoda K and C. Ronco, Publishers: Karger, Basel, Switzerland, 2013   Language:English   Book type:Scholarly book

  • 慢性腎臓病における心血管疾患. 4)脳卒中. 心腎相関の病態理解と診療.

    永田 雅治, 二宮 利治, 清原 裕,(Role:Edit)

    2008.1 

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    Responsible for pages:磯部光章 佐々木 成(編), 羊土社, 東京, 72-77, 2008   Language:Japanese   Book type:Scholarly book

  • 心血管病変:慢性腎機能障害における心血管病発症.

    二宮 利治, 平方 秀樹, 清原 裕.(Role:Edit)

    2006.1 

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    Responsible for pages:新しい診断と治療のABC(38) 透析合併症 秋葉 隆(編), 最新医学社, 大阪, 103-112, 2006   Language:Japanese   Book type:Scholarly book

  • 第1章 高血圧症の概念・定義 疫学 -日本人の高血圧症の特徴-.

    二宮 利治, 清原 裕.(Role:Edit)

    2004.1 

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    Responsible for pages:新しい診断と治療のABC(20) 高血圧症 猿田 亨男(編), 最新医学社, 大阪, 19-26, 2004   Language:Japanese   Book type:Scholarly book

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Presentations

  • Impact of midlife and late-life blood pressure on the development of dementia in Japanese elderly: the Hisayama Study. International conference

    Ninomiya T, Ohara T, Sekita A, Doi Y, Kanba S, Kiyohara Y.

    The 23rd Scientific Meeting of the International Society of Hypertension.  2010.9 

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    Event date: 2010.9

    Presentation type:Oral presentation (general)  

    Venue:Vancouver   Country:Canada  

  • Impact of kidney disease and blood pressure on the development of cardiovascular disease: Results from the Japan Arteriosclerosis Longitudinal Study. International conference

    Ninomiya T, Kiyohara Y, Tokuda Y, Doi Y, Arima H, Harada A, Ohashi Y, Ueshima H.

    The 15th World Congress of Heart Disease  2010.7 

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    Presentation type:Oral presentation (general)  

    Venue:Vancouver   Country:Canada  

  • Secular Trends of Chronic Kidney Disease and its Prognosis in a Japanese Community: The Hisayama Study. Invited International conference

    Ninomiya T, Kiyohara Y.

    The 1st Research Forum on Chronic Kidney Disease.  2007.2 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:Nagoya   Country:Japan  

  • The efficacy of lower blood pressure goals on the prevention of stroke in chronic kidney disease: data from the PROGRESS study. International conference

    Ninomiya T, Perkovic V, Gallagher M, Jardine M, Cass A, Neal B, Macmahon S, Chalmers J.

    American Society of Nephrology Renal Week 2007.  2007.11 

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    Presentation type:Oral presentation (general)  

    Venue:San Francisco   Country:United States  

  • Independent Impact of Albuminuria and Kidney Function on Cardiovascular Risk in Patients with Type 2 Diabetes: Results from the ADVANCE Trial. International conference

    Ninomiya T, Perkovic V, de Galan BE, Patel A, Cass A, Neal B, Cooper M, Mogensen CE, Williams B, MacMahon S, Chalmers J.

    American Society of Nephrology Renal Week 2008.  2008.11 

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    Presentation type:Oral presentation (general)  

    Venue:Philadelphia   Country:United States  

  • 日本におけるCKDの疫学. 慢性腎臓病と心血管病:久山町研究及びJALS統合研究. Invited

    二宮 利治, 清原 裕.

    第52回日本腎臓学会学術総会.  2009.6 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • The fixed combination of perindopril and indapamide has a greater effect on cardiovascular outcomes in patients with type 2 diabetes and albuminuria. International conference

    Ninomiya T, Heerspink HJL, Perkovic V, Zoungas S, Patel A, Grobbee D, Harrap S, Heller S, Cooper M, MacMahon S, Mancia G, Marre M, Neal B, Woodward M, Chalmers J.

    ISN Nexus Symposium Kyoto 2010  2010.4 

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    Presentation type:Oral presentation (general)  

    Venue:Kyoto   Country:Japan  

  • 認知機能における25-OHビタミンDの関連:海士町研究.<ポスター>

    古和久典、深田育代、中野俊也、岸 真文、和田健二、二宮利治、中島健二

    第42回日本認知症学会学術集会  2024.11 

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    Event date: 2024.11

    Presentation type:Poster presentation  

    Venue:奈良市   Country:Japan  

  • 地域住民を対象とした認知症の疫学研究<講義>

    二宮利治

    第一薬科大学看護学部講義  2024.11  第一薬科大 看護学部

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    Event date: 2024.11

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 地域住民を対象とした認知症の疫学研究.

    二宮利治

    第一薬科大学看護学部講義  2024.11 

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    Event date: 2024.11

    Venue:福岡市   Country:Japan  

  • 地域高齢住民における歯数とサルコペニア発症との関連:久山町研究.

    友岡祥子、柏﨑晴彦、二宮利治

    日本老年歯科医学会第35回学術大会  2024.6 

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    Event date: 2024.6

    Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  • 生活習慣と認知症.

    二宮利治

    若宮シニアクラブ第3回健康づくりセミナー  2024.6 

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    Event date: 2024.6

    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:粕屋郡   Country:Japan  

  • <シンポジウム30>老年医学における大規模データベースの活用.

    <座長> 寳澤 篤、二宮利治

    第66回日本老年医学会学術集会  2024.6 

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    Event date: 2024.6

    Presentation type:Symposium, workshop panel (nominated)  

    Venue:名古屋市   Country:Japan  

  • 地域認知症コホート研究の推進:久山町研究とJPSC-AD研究<シンポジウム30>老年医学における大規模データベースの活用.

    二宮利治

    第66回日本老年医学会学術集会  2024.6 

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    Event date: 2024.6

    Presentation type:Symposium, workshop panel (nominated)  

    Venue:名古屋市   Country:Japan  

  • 地域循環器コホート研究からの最近知見<会長特別企画2>九州の循環器コホートからの情報発信.

    二宮利治

    第136回日本循環器学会九州地方会  2024.6 

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    Event date: 2024.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:鹿児島市   Country:Japan  

  • 地域認知症コホート研究:久山町研究における最近の知見<会長企画シンポジウム1>コホート研究から健康長寿の鍵を紐解く.

    二宮利治

    第24回日本抗加齢医学会総会  2024.5 

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    Event date: 2024.5

    Presentation type:Oral presentation (invited, special)  

    Venue:熊本市   Country:Japan  

  • 地域疫学研究の実際.

    二宮利治

    九州大学大学院医療経営・管理学専攻講義  2024.5 

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    Event date: 2024.5

    Venue:福岡市   Country:Japan  

  • 食事と運動機能が認知症発症リスクに及ぼす影響:久山町研究.

    二宮利治

    第78回日本栄養・食糧学会大会  2024.5 

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    Event date: 2024.5

    Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • 地域認知症コホート研究の最近知見:久山町研究.

    二宮利治

    第25回九州老年期認知症研究会(Web講演会)  2024.5 

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    Event date: 2024.5

    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 心電図P波指標と心房細動発症、組織的線維化との関連:久山町研究.

    二宮利治

    COI-NEXT第26回弘前大学健康未来イノベーション研究機構運営会議(健康未来共創会議)  2024.5 

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    Event date: 2024.5

    Venue:弘前市   Country:Japan  

  • 血清asngiopoietin-like protein 2 (ANGPTL2)濃度と死因別死亡の関連:久山町研究.

    秦 淳、坂田智子、古田芳彦、大石絵美、本田貴紀、柴田舞欧、北園孝成、尾池雄一、二宮利治

    第60回日本循環器病予防学会学術集会  2024.5 

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    Event date: 2024.5

    Presentation type:Oral presentation (general)  

    Venue:東京都   Country:Japan  

  • <シンポジウム1>古くて新しい循環器疾患のマーカー.

    二宮利治

    第60回日本循環器病予防学会学術集会  2024.5  日本循環器予防学会学術集会

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    Event date: 2024.5

    Presentation type:Symposium, workshop panel (nominated)  

    Venue:東京都   Country:Japan  

  • 地域住民を対象とした認知症の疫学調査.

    二宮利治

    九州大学歯学部歯科全身管理学特別講義  2024.5 

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    Event date: 2024.5

    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • バイオバンクとデータ解析のワークショップ.

    二宮利治

    Tokyo Symposium & Workshop on Genomic Medicine, Therapeutics and Health、  2024.4 

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    Event date: 2024.4

    Presentation type:Symposium, workshop panel (nominated)  

    Venue:橿原市   Country:Japan  

  • 研究デザインや基本的な統計解析の手法について学ぼう.

    二宮利治

    第6回初学者のためのCKD臨床研究セミナー@九州大学  2024.3 

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    Event date: 2024.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • 地域住民における尿中神経伝達物質と抑うつ症状発症の関連:久山町研究.<ポスター>

    柴田舞欧、平林直樹、細井昌子、中村侑里、秦 淳、須藤信行、二宮利治

    第27回日本心療内科学会総会・学術大会  2023.12 

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    Event date: 2024.4

    Language:Japanese  

    Country:Japan  

  • 動脈硬化性疾患の疫学研究:久山町研究の最近の知見より.

    二宮利治

    第45回福岡東脳卒中の地域連携の夕べ  2024.2 

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    Event date: 2024.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:Web   Country:Japan  

  • 地域糖尿病コホート研究・久山町研究.

    二宮利治

    糖尿病治療を考える会、福岡市、2024.2  2024.2 

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    Event date: 2024.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • 地域高齢者住民を対象とした大規模認知症コホート研究(JPSC-AD研究)の取組.

    二宮利治

    第2回医療・健康ユニットシンポジウム  2024.3 

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    Event date: 2024.4

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 認知症予防における筋力・運動機能維持の重要性.

    二宮利治

    平尾公民館平尾大学  2024.3 

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    Event date: 2024.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 地域高齢住民における認知症有病率の時代的変化:久山町研究.

    小原知之、二宮利治

    第42回日本認知症学会学術集会  2023.11 

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    Event date: 2024.4

    Language:Japanese  

    Venue:奈良市   Country:Japan  

  • 地域住民における角膜ヒステリシスと緑内障の関連:久山町研究.

    藤原康太、上田瑛美、橋本左和子、中村 駿、秦 淳、中野聡子、村上祐介、久保田敏昭、吉冨健志、二宮利治、園田康平

    第127回日本眼科学会総会  2023.4 

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    Event date: 2024.4

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域住民における高血圧の有病率・管理状況および心血管病発症リスクの時代的推移:久山町研究.

    秦 淳、大石絵美、二宮利治

    第45回日本高血圧学会総会  2023.9 

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    Event date: 2024.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • 血漿認知症バイオマーカーと認知症発症の関係:地域前向きコホート研究の成績より.

    小原知之、秦 淳、徳田隆彦、本田貴紀、柴田舞欧、中路重之、前田哲也、小野賢二郎、三村 將、中島健二、伊賀淳一、竹林 実、二宮利治

    第38回日本老年精神医学会秋季大会  2023.10 

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    Event date: 2024.4

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 疫学.

    二宮利治

    令和健康科学大学講義  2023.11 

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    Event date: 2024.4

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 認知症の血漿バイオマーカーと認知症発症との関連<シンポジウム15>認知症バイオマーカー研究の最新知見.

    小原知之、二宮利治

    第42回日本認知症学会学術集会  2023.11 

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    Event date: 2024.4

    Language:Japanese  

    Venue:奈良市   Country:Japan  

  • 地域疫学研究を基盤とした脳梗塞発症のリスク予測:久山町研究<シンポジウム9>データベース研究の新展開.

    秦 淳、二宮利治

    第66回日本脳循環代謝学会学術集会  2023.11 

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    Event date: 2024.4

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 久山町コホートからみた生活習慣病・生活習慣と脳画像との関連<シンポジウム3>地域コホート研究からみた生活習慣・生活習慣病と脳画像との関連.

    小原知之、二宮利治

    第42回日本認知症学会学術集会  2023.11 

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    Event date: 2024.4

    Language:Japanese  

    Venue:奈良市   Country:Japan  

  • 古和久典、深田育代、中野俊也、岸 真文、和田健二、二宮利治、中島健二

    認知機能における25-CHビタミンDの関連:海士町研究.<ポスター>

    第42回日本認知症学会学術集会  2023.11 

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    Event date: 2024.4

    Language:Japanese  

    Venue:奈良市   Country:Japan  

  • 陳 俐穎、舘脇康子、Benjamin Thyreau、内田和宏、壹岐ひかり、中瀬泰然、中路重之、前田哲也、野口・篠原もえ子、三村 將、中島健二、伊賀淳一、竹林 実、二宮利治、瀧 靖之

    白質病変の定量化による日本人大規模高齢者集団の食事パターンと認知症に関する研究.<ポスター>

    第42回日本認知症学会学術集会  2023.11 

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    Event date: 2024.4

    Language:Japanese  

    Venue:奈良市   Country:Japan  

  • 水野裕理、本田裕之、二宮利治、磯部紀子、村井弘之

    アルツハイマー型認知症の脳内におけるトランスサイレチンの発現様式の検討.<ポスター>

    第42回日本認知症学会学術集会  2023.11 

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    Event date: 2024.4

    Language:Japanese  

    Venue:奈良市   Country:Japan  

  • 日本人地域住民における座位行動と糖代謝マーカーの経時変化および糖尿病発症の関連:久山町研究. International conference

    津田 晋、本田貴紀、東岡真由、秦 淳、中野敏昭、北園孝成、二宮利治

    第34回日本疫学会学術総会  2024.2 

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    Event date: 2024.2

    Language:Japanese   Presentation type:Poster presentation  

    Venue:大津市   Country:Japan  

  • 地域住民における健康管理への取組~久山町研究~.

    二宮利治

    Oriental land Friendship Society九州研修  2024.1 

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    Event date: 2024.2

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 久山町研究からの最近の知見.

    二宮利治

    NCVC Seminar Series  2024.1 

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    Event date: 2024.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:吹田市   Country:Japan  

  • 全国の一般地域住民における最近の循環器疾患発症率.<ポスター>

    門田 文、大久保孝義、原田亜紀子、高嶋直敬、有馬久富、二宮利治、秦 淳、寶澤 篤、中村幸志、東山 綾、大澤正樹、久松隆史、鳥居さゆ希、岡見雪子、近藤慶子、宮本恵宏、岡村智教、上島弘嗣、岡山 明、三浦克之

    第34回日本疫学会学術総嶋  2024.2 

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    Event date: 2024.2

    Presentation type:Poster presentation  

    Venue:大津市   Country:Japan  

  • 地域住民における社会的・情緒的孤独感と慢性疼痛の関連:久山町研究.

    柴田舞欧、平林直樹、細井昌子、安野広三、秦 淳、須藤信行、二宮利治

    第30回日本未病学会学術総会  2023.12 

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    Event date: 2024.1

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 臨床・疫学研究の進め方.

    二宮利治

    岩手医科大学 講演会  2023.12 

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    Event date: 2024.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岩手県矢巾町   Country:Japan  

  • 大規模認知症コホート研究(JPSC-AD)について.

    二宮利治

    やはば脳とカラダのいきいき健康事業、いきいき記念講演会2023  2023.12 

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    Event date: 2024.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岩手県矢巾町   Country:Japan  

  • 高齢者保健.

    二宮利治

    令和健康科学大学講義  2023.12 

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    Event date: 2024.1

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 感染症.

    二宮利治

    令和健康科学大学講義  2023.12 

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    Event date: 2024.1

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 認知症発症のリスク低減における生活習慣病予防および運動機能維持の重要性:久山町研究.<特別講演>

    二宮利治

    大牟田臨床認知症研究会第34回特別講演会  2023.12 

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    Event date: 2024.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大牟田市   Country:Japan  

  • 久山町研究のこれから<記念シンポジウム>久山町研究の過去、未来.

    二宮利治

    九州大学医学部120周年を祝う会  2023.12 

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    Event date: 2024.1

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 日本人地域住民における教育年数と眼軸長および開放隅角緑内障の関連:久山町研究.

    中村 駿、上田瑛美、藤原康太、柴田舞欧、安田美穂、本田貴紀、橋本左和子、秦 淳、二宮利治、園田康平

    第5回日本近視学会総会  2023.5 

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    Event date: 2024.1

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 日本人地域住民におけるサルコペニアの疫学:久山町研究<シンポジウム9>筋肉・サルコペニア肥満.

    秦 淳、二宮利治

    第44回日本肥満学会・第41回日本肥満症治療学会学術集会  2023.11 

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    Event date: 2023.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:仙台市   Country:Japan  

  • <シンポジウム15>認知症バイオマーカー研究の最新知見.<座長>

    二宮利治、徳田隆彦

    第42回日本認知症学会学術集会  2023.11 

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    Event date: 2023.12

    Language:Japanese  

    Venue:奈良市   Country:Japan  

  • 動脈硬化性疾患のリスク評価:久山町研究.

    二宮利治

    宗像内科医会学術講演会  2023.9 

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    Event date: 2023.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:Web   Country:Japan  

  • 日本人地域住民における血清NT-proBNPの変化と慢性腎臓病発症との関連:久山町研究.

    大石絵美、坂田智子、秦 淳、北園孝成、二宮利治

    第45回日本高血圧学会総会  2023.9 

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    Event date: 2023.12

    Language:Japanese  

    Venue:大阪   Country:Japan  

  • 日本人一般集団における血圧の日間変動と慢性腎臓病発症リスク

    佐々木峻也、坂田智子、大石絵美、秦 淳、坪井伸夫、北園孝成、横尾 隆、二宮利治

    第45回日本高血圧学会総会、大阪市、2023.9  2023.8 

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    Event date: 2023.12

    Language:Japanese  

    Country:Japan  

  • 白衣高血圧は心血管病発症の危険因子となるか?:久山町研究.

    坂田智子、大石絵美、秦 淳、北園孝成、二宮利治

    第45回日本高血圧学会総会  2023.9 

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    Event date: 2023.12

    Language:Japanese  

    Venue:大阪   Country:Japan  

  • 1機会に測定した1回目と2回目の家庭血圧値の変化に影響する因子の検討:福岡高血圧コホート(FHC)研究.

    寒水康雄、松村 潔、大森 将、坂田智子、大坪俊夫、冨永光裕、鍵山俊太郎、川﨑純也、赤崎 卓、藤島八重、阿部 功、二宮利治、後藤健一、𡈽橋卓也、北園孝成

    第45回日本高血圧学会総会  2023.9 

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    Event date: 2023.12

    Language:Japanese  

    Venue:大阪   Country:Japan  

  • <ランチョンセミナー5>認知症発症のリスク低減における生活習慣病予防および運動機能維持の重要性:久山町研究.

    二宮利治

    第12回日本認知症予防学会学術集会  2023.9 

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    Event date: 2023.12

    Language:Japanese  

    Country:Japan  

  • Association of impaired olfactory identification with prevalent mild cognitive impairment and regional brain atrophy:the Hisayama Study.<poster> International conference

    Minohara T, Ohara T, Nakazawa T, Hirabayashi N, Hata J, Furuta Y, Mihara A, Shibata M, Kitazono T, Nakao T, Ninomiya T

    23rd WPA World Congress of Psychiatry, Vienna, Austria, 2023.9  2023.9 

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    Event date: 2023.12

    Language:English  

    Venue:Austria   Country:Japan  

  • 認知症・要介護予防におけるロコモ・フレイル対策の重要性:久山町研究の成績より.

    二宮利治

    第4回元気100倶楽部健康長寿フェア2023  2023.10 

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    Event date: 2023.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 日本人地域高齢住民における網膜症と認知症発症との関連:久山町研究.

    中村 駿、上田瑛美、小原知之、秦 淳、本田貴紀、藤原康太、古田芳彦、柴田舞欧、橋本左和子、中澤太郎、中尾智博、北園孝成、園田康平、二宮利治

    第77回日本臨床眼科学会  2023.10 

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    Event date: 2023.12

    Language:Japanese  

    Venue:東京   Country:Japan  

  • <特別企画4>包括的RWD構築(データ連携)最前線.

    二宮利治

    弘前大学COI-NEXT Well-being イノベーションフォーラム2023  2023.10 

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    Event date: 2023.12

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域住民を対象とした認知症の疫学研究.

    二宮利治

    第一薬科大学看護学部講義  2023.10 

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    Event date: 2023.12

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡   Country:Japan  

  • <ランチョンセミナー>地域住民における動脈硬化性疾患の疫学研究-久山町研究-.

    二宮利治

    第63回日本臨床化学会年次学術集会  2023.10 

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    Event date: 2023.12

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:東京   Country:Japan  

  • 認知症予防における筋力・運動機能維持の重要性.

    二宮利治

    九州市民大学令和5年度「秋の集中講義」  2023.10 

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    Event date: 2023.12

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 専門家部門最優秀賞(YIA)最終候補発表会.

    二宮利治

    日本臨床疫学会第6回年次学術大会  2023.11 

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    Event date: 2023.12

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域住民における尿中神経伝達物質と抑うつ症状の有無の関連:久山町研究.

    柴田舞欧、平林直樹、細井昌子、中村侑里、秦 淳、須藤信行、二宮利治

    日本臨床疫学会第6回年次学術大会  2023.11 

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    Event date: 2023.12

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 総論、公衆衛生活動のプロセス

    二宮利治

    令和健康科学大学講義  2023.11 

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    Event date: 2023.12

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • <シンポジウム3>地域コホート研究からみた生活習慣・生活習慣病と脳画像との関連.<座長>

    小野賢二郎、二宮利治

    第42回日本認知症学会学術集会  2023.11 

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    Event date: 2023.12

    Language:Japanese  

    Venue:奈良市   Country:Japan  

  • 高齢者の肥満型フレイルにおける脳容積の検討:JPSC-AD研究.<ポスター>

    石塚直樹、赤坂 博、佐藤光信、佐藤裕里子、細川一貴、本田貴紀、柴田舞欧、小原知之、秦 淳、舘脇康子、瀧靖之、二宮利治、前田哲也

    第42回日本認知症学会学術集会  2023.11 

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    Event date: 2023.11

    Language:Japanese  

    Venue:奈良市   Country:Japan  

  • Brain at risk: socioeconomic-lifestyle burden on Japanese and Swedish female.<poster>

    Liu Y, Takewaki Y, Thyreau B, Zhang Y, Boraxbekk B, Hidaka Y, Kajitani K, Yuki S, Takebayashi M, Ninomiya T, Taki Y, Karalija N

    第42回日本認知症学会学術集会  2023.11 

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    Event date: 2023.11

    Presentation type:Poster presentation  

    Venue:奈良市   Country:Japan  

  • 認知症の地域疫学研究:久山町研究<シンポジウム16>認知症の予防・治療法を目指した本邦のコホート研究.

    <座長>小野賢二郎、二宮利治

    第41回日本神経治療学会学術集会  2023.11 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 地域高齢住民におけるpreserved ratio impaired spirometryと認知症の関連:久山町研究.

    川床健司、鷲尾康圭、小原知之、福山 聡、本田貴紀、秦 淳、中澤太郎、神尾敬子、井上博雅、松元幸一郎、中尾智博、北園孝成、岡本 勇、二宮利治

    第116回呼吸生理フォーラム・第96回閉塞性肺疾患研究会  2023.7 

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    Event date: 2023.9

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 脳萎縮および白質病変が認知症発症に及ぼす影響:久山町研究<シンポジウム29>わが国における認知症の疫学研究の最前線.

    中澤太郎、小原知之、二宮利治

    第119回日本精神神経学会学術総会  2023.6 

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    Event date: 2023.7

    Language:Japanese  

    Venue:横浜市   Country:Japan  

  • 剖検例における耐糖能と膵β・α細胞量に関する検討:久山町研究.

    稲石 淳、税所芳史、平川洋一郎、吉田大悟、秦 淳、向井直子、渡辺雄祐、小田義直、伊藤 裕、二宮利治

    第117回日本内科学会総会  2020.4 

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    Event date: 2023.7

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 地域住民の口腔の健康状態の経年的変化と歯科疾患実態調査との比較.

    吉田美智子、竹内研時、竹下 徹、須磨紫乃、影山伸哉、朝川美加李、黒江 慧、柴田幸江、嶋崎義浩、二宮利治、山下喜久

    第69回日本口腔衛生学会・総会、誌上  2020.4 

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    Event date: 2023.7

    Language:Japanese  

    Venue:誌上   Country:Japan  

  • 地域高齢住民における中年期および高齢期の糖尿病罹患とサルコペニア発症の関連-久山町研究-.

    中村公隆、吉田大悟、本田貴紀、秦 淳、柴田舞欧、平川洋一郎、古田芳彦、岸本裕歩、北園孝成、中島康晴、二宮利治

    第93回日本整形外科学会学術総会  2020.6 

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    Event date: 2023.7

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 慢性腎臓病(CKD)対策連携システムのCKD進行抑制効果の検証.

    片渕律子、田中 茂、二宮利治

    第63回日本腎臓学会学術総会  2020.9 

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    Event date: 2023.7

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 血圧、糖尿病、喫煙、高脂血症と心血管疾患死亡の生涯リスクの関連:EPOCH-JAPAN.

    今井由希子、村上義孝、二宮利治、宮本恵宏、石川鎮清、坂田清美、磯 博康、中川秀昭、大久保孝義、玉腰暁子、斎藤重幸、三浦克之、上島弘嗣、岡村智教

    第79回日本公衆衛生学会総会  2020.10 

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    Event date: 2023.7

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 我が国の地域住民における筋トレの実態:久山町研究<シンポジウム7>筋トレの疫学.

    本田貴紀、二宮利治

    第76回日本体力医学会大会  2021.9 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 認知症発症の血液バイオマーカー探索:久山町研究<シンポジウム30>認知症バイオマーカー:血液による診断評価という新時代.

    小原知之、二宮利治

    第117回日本精神神経学会学術総会  2021.9 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:WEB   Country:Japan  

  • 慢性腎臓病患者における石灰化と冠状動脈内膜出血の関係:久山町研究.

    中野敏昭、北村博雅、小田義直、北園孝成、二宮利治

    第53回日本動脈硬化学会総会・学術集会  2021.10 

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    Event date: 2023.7

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 糖尿病とアルツハイマー病罹患との関連:JPSC-AD研究.<ポスター>

    篠原もえ子、柚木颯偲、阿部智絵美、森 彩香、堀本真以、横川正美、石田奈津子、菅 幸生、石崎純子、石宮 舞、中村博幸、駒井清暢、中村裕之、柴田舞欧、小原知之、秦 淳、二宮利治、山田正仁、JPSC-AD研究グループ

    第40回日本認知症学会学術総会  2021.11 

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    Event date: 2023.7

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 地域高齢住民におけるBMIレベルとフレイルの関係:JPSC-AD研究.<ポスター>

    石塚直樹、赤坂 博、佐藤光信、佐藤裕里子、高橋純子、米澤久司、陳 三妹、本田貴紀、小原知之、秦 淳、熊谷秋三、二宮利治、前田哲也

    第40回日本認知症学会学術総会  2021.11 

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    Event date: 2023.7

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 身体的フレイルと認知症との関連:JPSC-AD 研究.

    赤坂 博、石塚直樹、佐藤光信、佐藤裕里子、高橋純子、米澤久司、陳 三妹、本田貴紀、柴田舞欧、小原知之、秦 淳、熊谷秋三、二宮利治、前田哲也

    第40回日本認知症学会学術総会  2021.11 

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    Event date: 2023.7

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • Impact of social activity on depressive symptoms and brain regional gray matter.<poster>

    Liu Y, Thyreau B, Tatewaki Y, Zhang Y, Matsudaira I, Takano Y, Hirabayashi N, Furuta Y, Hata J, Ninomiya T, Taki Y

    第40回日本認知症学会学術総会  2021.11 

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    Event date: 2023.7

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 公衆衛生の歴史とその概念.

    二宮利治

    原看護専門学校  2023.4 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 公衆衛生活動のシステムとプロセス.

    二宮利治

    原看護専門学校  2023.4 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 疫学.

    二宮利治

    原看護専門学校  2023.4 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 生活習慣が認知症発症に及ぼす影響~久山町研究の成績より~<市民公開セッション4>認知症1000万人時代に備えて知っておきたい、知識と医療!.

    二宮利治

    第31回日本医学会総会  2023.4 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 認知症の地域疫学:久山町研究.

    二宮利治

    第29回日本認知症学会教育セミナー、Web、2023.4  2023.4 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:WEB   Country:Japan  

  • 地域住民を対象とした認知症の疫学調査.

    二宮利治

    九州大学歯学部歯科全身管理学講義  2023.5 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 高齢者保健.

    二宮利治

    原看護専門学校  2023.5 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 地域住民におけるサルコペニア肥満と心血管病発症の関連-久山町研究-.

    瀬戸山 優、多治見昂洋、本田貴紀、秦 淳、北園孝成、中島康晴、二宮利治

    第96回日本整形外科学会学術集会  2023.5 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:横浜市   Country:Japan  

  • 生活習慣病の地域疫学研究:久山町研究~眼科疾患の調査成績も含めて~.

    二宮利治

    第5回日本近視学会総会  2023.5 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 地域高齢住民におけるサルコペニアと脳萎縮との関連-久山町研究-.

    多治見昂洋、平林直樹、古田芳彦、本田貴紀、秦 淳、小原知之、柴田舞欧、北園孝成、中島康晴、二宮利治

    第96回日本整形外科学会学術集会  2023.5 

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    Event date: 2023.7

    Language:Japanese  

    Venue:横浜市   Country:Japan  

  • 地域住民における皮膚カルテノイドレベルとメタボリックシンドロームの関連:久山町研究.

    木村安美、秦 淳、柴田舞欧、本田貴紀、坂田智子、古田芳彦、大石絵美、北園孝成、二宮利治

    第77回日本栄養・食糧学会大会  2023.5 

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    Event date: 2023.7

    Language:Japanese  

    Venue:札幌市   Country:Japan  

  • 眼科疾患に関する地域疫学研究:久山町研究.

    二宮利治

    第14回弘前大学健康未来イノベーション研究機構運営会議〈拡大版〉  2023.5 

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    Event date: 2023.7

    Language:Japanese  

    Venue:弘前市   Country:Japan  

  • 認知症発症のリスク低減における筋力・運動機能維持の重要性:久山町研究.

    二宮利治

    第32回福岡県理学療法士学会  2023.5 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • 地域高齢住民における慢性疼痛が痛み関連脳領域の容積に及ぼす影響に関する縦断的解析.

    中村侑里、柴田舞欧、古田芳彦、中澤太郎、山浦 健、二宮利治

    日本麻酔科学会第70回学術集会  2023.6 

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    Event date: 2023.7

    Language:Japanese  

    Venue:神戸市   Country:Japan  

  • 認知症・身体機能.

    赤坂 憲、二宮利治

    第59回日本循環器病予防学会学術集会  2023.6 

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    Event date: 2023.7

    Language:Japanese  

    Venue:鹿児島市   Country:Japan  

  • ヒトを対象とした研究:地域疫学研究の実際. Invited

    二宮利治

    令和5年度宮崎西高校理数科・理文クラス講演会  2023.6 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:宮崎市   Country:Japan  

  • 我が国の中年者および高齢者におけるてんかん有病率:久山町研究.

    田中章浩、秦 淳、赤松直樹、水野敏樹、北園孝成、二宮利治

    第53回日本てんかん学会、神戸市、2019.10  2019.10 

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    Event date: 2023.7

    Language:Japanese  

    Venue:神戸市   Country:Japan  

  • 地域住民における認知症の疫学研究:久山町研究.

    二宮利治

    第30回日本医学会総会2019中部  2019.4 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋市   Country:Japan  

  • 日本人での耐糖能とβ細胞機能および膵組 織学的特徴との関連についての検討.

    稲石 淳、税所芳史、向井直子、平川洋一郎、吉田大悟、秦 淳、渡辺雄祐、小田義直、伊藤 裕、二宮利治

    第62回日本糖尿病学会年次学術集会、第2回若手研究助成金成果報告会  2019.5 

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    Event date: 2023.7

    Language:Japanese  

    Venue:仙台市   Country:Japan  

  • 日本人のアテローム血栓性脳梗塞の強力な遺伝子多型RNF213p.4810K.

    猪原匡史、岡崎周平、森本貴昭、鎌谷洋一郎、上村鉄平、原田浩二、冨田 努、東山 綾、高橋 淳、中川原譲二、古賀政利、豊田一則、鷲田和夫、齊藤 聡、望月秀樹、秦 淳、二宮利治、吾郷哲朗、久保充明、小林昭夫

    第60回日本神経学会学術大会  2019.5 

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    Event date: 2023.7

    Language:Japanese  

    Venue:大阪市   Country:Japan  

  • 小学校でのフッ化物洗口の経験と成人のう蝕との関係.

    古田美智子、竹内研時、竹下 徹、須磨紫乃、影山伸哉、朝川美加李、奥菜央理、黒江 慧、高尾直宏、柴田幸江、二宮利治、山下喜久

    第41回九州口腔衛生学会総会  2019.9 

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    Event date: 2023.7

    Language:Japanese  

    Venue:北九州市   Country:Japan  

  • 脳卒中予防の最前線:久山町研究の成績より<メディカルスタッフ教育セミナー3>.

    秦 淳、二宮利治

    第59回日本循環器病予防学会学術集会  2023.6 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鹿児島市   Country:Japan  

  • 海馬亜領域の糖尿病に対する脆弱性.<ポスター>

    島 綾乃、篠原もえ子、小松潤史、柴田修太郎、坂下泰浩、村松大輝、疋島貞雄、ティロ― バンジャマン、舘脇康子、瀧 靖之、二宮利治、小野賢二郎

    第64回日本神経学会学術大会  2023.6 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Poster presentation  

    Venue:千葉市   Country:Japan  

  • つらい痛みを予防するには?~みんなの痛みを心身医学的疫学研究からみる~.

    柴田舞欧、安野広三、二宮利治、細井昌子

    第52回日本慢性疼痛学会  2023.3 

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    Event date: 2023.6

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 一般住民におけるLATE-NCの頻度と病理学的特徴:久山町研究<ポスター>.

    森 慎一郎、本田裕之、濱崎英臣、小原知之、二宮利治、岩城 徹

    第63回日本神経学会学術大会  2022.5 

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    Event date: 2023.6

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域高齢住民における認知症の実態とその危険因子:久山町研究<シンポジウム59>わが国で進行中の疫学研究からみた認知症の発症リスク低減.

    小原知之、二宮利治

    第118回日本精神神経学会学術総会  2022.6 

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    Event date: 2023.6

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 脳の部位別灰白質萎縮が認知症発症に与える影響:久山町研究<シンポジウム18>本邦における認知症コホート研究の最前線.

    小原知之、二宮利治

    第41回日本認知症学会学術集会・第37回日本老年精神医学会、東京、2022.11  2022.6 

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    Event date: 2023.6

    Language:Japanese  

    Venue:東京   Country:Japan  

  • PCBP2 is downregulated in degenerating neurons and rarely observed in skein-like inclusions in ALS.<poster>

    Yoshimura M, Honda H, Sasagasako N, Mori S, Ishii T, Ninomiya T, Isobe N, Iwaki T

    第63回日本神経学会学術大会  2022.5 

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    Event date: 2023.6

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 一般住民における年代別脳重量低下:久山町研究.

    本田裕之、小原知之、八木田 薫、濱崎英臣、小山祥子、野口英子、秦 淳、二宮利治、岩城 徹

    第63回日本神経病理学会総会学術研究会  2022.6 

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    Event date: 2023.6

    Language:Japanese  

    Venue:京都市   Country:Japan  

  • 日本人地域住民における角膜ヒステリシスと緑内障の関連:久山町研究.

    藤原康太、上田瑛美、橋本左和子、中村 駿、秦 淳、中野聡子、村上祐介、久保田敏昭、吉冨健志、二宮利治、園田康平

    第33回日本緑内障学会  2022.9 

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    Event date: 2023.6

    Language:Japanese  

    Venue:横浜市   Country:Japan  

  • MCI (aMCI・naMCI)における健康関連QOLとそれに関連する臨床的特徴<ポスター>.

    深田育代、古和久典、中野俊也、二宮利治、中島健二

    第41回日本認知症学会学術集会・第37回日本老年精神医学会  2022.11 

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    Event date: 2023.6

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域住民における認知症の実態とその危険因子:久山町研究確<シンポジウム14>認知症コホートを用いた生物学的研究の最前線.

    小原知之、二宮利治

    BPCNPNPPP4学会合同年会  2022.11 

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    Event date: 2023.6

    Language:Japanese  

    Venue:東京   Country:Japan  

  • Distributions and risk factors in ARTAG formation: The Hisayama study.<poster>

    八木田 薫、小原知之、濱崎英臣、小山祥子、野口英子、秦 淳、二宮利治、本田裕之

    第41回日本認知症学会学術集会・第37回日本老年精神医学会  2022.11 

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    Event date: 2023.6

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 深層学習によるMRI画像からの咬筋測定プログラム開発及び疫学的意義に関する初期検討<ポスター>.

    武田 研、舘脇康子、Thyreau Benjamin、村中美千帆、阪本真弥、二宮利治、瀧 靖之

    第41回日本認知症学会学術集会・第37回日本老年精神医学会、東京、2022.11  2022.11 

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    Event date: 2023.6

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域高齢者住民における歯数とサルコペニア発症との関連:久山町研究.

    友岡祥子、坂田智子、大石絵美、本田貴紀、秦 淳、古田美智子、山下喜久、和田尚久、北園孝成、二宮利治

    第33回日本老年医学会九州地方会  2023.3 

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    Event date: 2023.6

    Language:Japanese  

    Venue:北九州市   Country:Japan  

  • 特定健診における動脈硬化性疾患発症リスク予測モデルの評価可能性:大規模健診・医療レセプトデータベースを用いた検討.

    本田貴紀、陳 三妹、石田有紀、木村安美、吉田大悟、二宮利治

    第24回日本健康支援学会年次学術大会、福岡市、2023.3  2023.3 

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    Event date: 2023.6

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 生活習慣と認知症.

    二宮利治

    九州漢方研究会・市民講演会、  2023.3 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 住民コホート研究から日本の未来を読み解く.

    二宮利治

    第87回日本循環器学会学術集会  2023.3 

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    Event date: 2023.6

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • Conventional and novel risk factors for cardiovascular disease: the Hisayama Study.

    秦 淳、二宮利治

    第87回日本循環器学会学術集会  2023.3 

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    Event date: 2023.6

    Language:Japanese  

    Country:Japan  

  • 地域一般住民における家庭血圧日間変動と心房細動発症との関連:久山町研究.

    前園明寛、坂田智子、秦 淳、大石絵美、井手友美、北園孝成、筒井裕之、二宮利治

    第87回日本循環器学会学術集会  2023.3 

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    Event date: 2023.6

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 認知症・要介護予防におけるロコモ・フレイル対策の重要性.

    二宮利治

    平尾公民館平尾大学  2023.3 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 地域住民における認知症コホート研究~筋力低下予防の重要性:久山町研究.

    二宮利治

    第24回認プロFD講演会  2023.2 

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    Event date: 2023.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:WEB   Country:Japan  

  • 認知症発症のリスク低減における筋力・運動機能維持の重要性:久山町研究.

    二宮利治

    日本抗加齢医学会九州地方会、福岡市、2023.2  2023.2 

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    Event date: 2023.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • Association between sarcopenic obesity and risk of cardiovascular disease: The Hisayama Study. <poster> International conference

    Setoyama Y, Tajimi T, Honda T, Hata J, Kitazono T, Nakashima Y, Ninomiya T

    Orthopaedic Research Society 2023 Annual Meeting  2023.2 

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    Event date: 2023.3

    Language:English  

    Venue:Dallas、Texas   Country:Japan  

  • 糖尿病の地域疫学研究:久山町研究.

    二宮利治

    成人歯科保健衛生講習会  2023.1 

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    Event date: 2023.3

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 今からでもできる!ロコモ・フレイル予防!(運動編).

    二宮利治

    第9回ひさやま健康セミナー、糟屋郡、2023.2  2023.2 

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    Event date: 2023.3

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 臨床研究の進め方.

    二宮利治

    第5回初学者のためのCKD臨床研究セミナー@九州大学2023  2023.2 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • 社会変革型データサイエンスグループ

    二宮利治

    九州大学未来社会デザイン総括本部医療・健康ユニットキックオフシンポジウム  2023.2 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡市   Country:Japan  

  • 地域住民における腸内細菌叢メタボリックシンドロームの関係:久山町研究.

    坂田智子、古田芳彦、大石絵美、秦 淳、本田貴紀、柴田舞欧、北園孝成、二宮利治

    第15回福岡県医学会総会  2023.2 

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    Event date: 2023.3

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 地域住民における認知症発症リスク予測モデルの開発:久山町研究<特別企画3>データ連携最前線.

    二宮利治

    弘前大学COI-NEXT Well-being イノベーションサミット2023  2023.2 

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    Event date: 2023.3

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 地域住民における動脈硬化性疾患のリスク評価:久山町研究.

    二宮利治

    第15回佐賀DALM  2023.2 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:佐賀市   Country:Japan  

  • Association between sarcopenia and regional brain atrophy in a general older population: The Hisayama Study. <poster> International conference

    Tajimi T, Hirabayashi N, Furuta Y, Honda T, Hata J, Ohara T, Shibata M, Kitazono T, Ninomiya T, Nakashima Y

    Orthopaedic Research Society 2023 Annual Meeting  2023.2 

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    Event date: 2023.3

    Language:English  

    Venue:Dallas、Texas   Country:Japan  

  • 疫学的視点から見る認知症発症リスク低減の可能性:久山町研究.

    二宮利治

    日本認知症ケア学会2022年度九州・沖縄ブロック大会  2023.2 

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    Event date: 2023.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:WEB   Country:Japan  

  • Association between vegetable intakes and dementia risk in a community-dwelling older population of Japanese: the Hisayama study<Symposium>Reevaluate the Value of Vegetables -the Perspective of Behavior Change and Nutrition-. International conference

    Ninomiya T

    22nd IUNS-Intenational Congress of Nutrition  2022.12 

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    Event date: 2023.2

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Tokyo   Country:Japan  

  • 地域住民における認知症発症リスク予測モデルの開発:久山町研究<シンポジウム10>アルツハイマー病発症予防に向けた新規バイオマーカー・治療法の開発.

    二宮利治

    第41回日本認知症学会学術集会・第37回日本老年精神医学会  2022.11 

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    Event date: 2023.2

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域認知症コホート研究からみた生活習慣や生活習慣病と認知症リスクの関係<シンポジウム48>生活習慣介入によるAD予防のエビデンス.

    二宮利治

    第41回日本認知症学会学術集会・第37回日本老年精神医学会  2022.11 

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    Event date: 2023.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 地域高齢住民における糖尿病および慢性腎臓病と認知症の関係:久山町研究.<教育講演>

    二宮利治

    第33回日本糖尿病性腎症研究会  2022.12 

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    Event date: 2023.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢市   Country:Japan  

  • 高齢者保健.

    二宮利治

    令和健康科学大学理学療法学科、作業療法学科  2022.12 

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    Event date: 2023.2

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 感染症.

    二宮利治

    令和健康科学大学理学療法学科、作業療法学科  2022.12 

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    Event date: 2023.2

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • Risk assessment of arteriosclerotic disease in a general population: the Hisayama study. International conference

    Ninomiya T

    22nd IUNS-Intenational Congress of Nutrition  2022.12 

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    Event date: 2023.2

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Tokyo   Country:Japan  

  • 現在の公衆衛生のシステムと政策-保険医療行政の概要、保険制度・医療制度・医療保障・年金・社会福祉の仕組み.

    二宮利治

    令和健康科学大学理学療法学科、作業療法学科  2022.11 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 高齢者の医療と福祉

    二宮利治

    第81回日本公衆衛生学会総会  2022.10 

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    Event date: 2022.12

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 血清グリコアルブミン値と心血管病発症との関係:久山町研究.

    二宮利治

    DiaMond Seminar  2022.10 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 日本人地域住民における血圧管理レベル別にみた心血管病発症率の時代的推移:久山町研究.

    大石絵美、坂田智子、秦 淳、平川洋一郎、北園孝成、二宮利治

    第44回日本高血圧学会総会  2022.10 

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    Event date: 2022.12

    Language:Japanese  

    Venue:京都市   Country:Japan  

  • 健診データを用いた臨床研究の実際.

    二宮利治

    第60回全国大学保険管理研究集会  2022.10 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜市   Country:Japan  

  • 地域高齢住民における糖尿病および慢性腎臓病と認知症の関係:久山町研究<シンポジウム>わが国における糖尿病合併症に関するエビデンス.

    二宮利治

    第37回日本糖尿病合併症学会・第28回日本糖尿病眼学会総会  2022.10 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:WEB   Country:Japan  

  • 血清グリコアルブミン値と心血管病発症との関係:久山町研究.

    二宮利治

    DiaMond Seminar  2022.11 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:WEB   Country:Japan  

  • 生活習慣病と認知症.

    二宮利治

    第一薬科大学講義  2022.11 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 臨床研究における多変量解析の考え方.

    二宮利治

    第4回臨床研究と統計を考える会  2022.11 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:WEB   Country:Japan  

  • <ランチョンセミナー>医療情報データベースで何ができるのか?

    二宮利治

    日本臨床疫学会第5回年次学術大会  2022.11 

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    Event date: 2022.12

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域高齢者における慢性腰痛と領域別脳容積の関連:久山町研究.

    柴田舞欧、浅田雅子、平林直樹、小原知之、古田芳彦、中澤太郎、本田喜紀、秦 淳、二宮利治

    日本臨床疫学会第5回年次学術大会  2022.11 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • <シンポジウム>脳画像データを用いた疫学研究.

    二宮利治

    日本臨床疫学会第5回年次学術大会  2022.11 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 最優秀賞(YIA)最終候補発表会.

    二宮利治

    日本臨床疫学会第5回年次学術大会  2022.11 

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    Event date: 2022.12

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域住民における認知症コホート研究~筋力低下予防の重要性:久山町研究令和の日本人の健康と日常を快適に過ごすための細胞-身体活性化法.

    二宮利治

    第29回日本未病学会学術総会  2022.11 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:WEB   Country:Japan  

  • 地域住民における動脈硬化性疾患のリスク評価:久山町研究.

    二宮利治

    中央区内科医会学術講演会  2022.11 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 地域住民における認知症コホート研究:久山町研究とJPSC-AD研究の成績より.

    二宮利治

    第36回21世紀の認知症を考える会  2022.11 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:WEB   Country:Japan  

  • 疫学研究の成果からみた認知症リスク低減の可能性:久山町研究.

    二宮利治

    第15回高岡市の認知症を考える会・高岡市医師会認知症・地域ケア相談医研修会  2022.11 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:高岡市   Country:Japan  

  • 地域住民における心理社会的因子と慢性疾患の関係:久山町研究.

    二宮利治

    第26回日本心療内科学会総会・学術大会  2022.11 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • 地域高齢住民における領域別脳容積と慢性腰痛との関連:久山町研究.<ポスター>

    柴田舞欧、浅田雅子、平林直樹、小原知之、古田芳彦、中澤太郎、本田喜紀、秦 淳、細井昌子、二宮利治、須藤信行

    第26回日本心療内科学会総会・学術大会  2022.10 

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    Event date: 2022.12

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 総論-公衆衛生と医療の歴史、公衆衛生活動、生命倫理と保険医療福祉の倫理.

    二宮利治

    令和健康科学大学理学療法学科、作業療法学科  2022.11 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 公衆衛生活動のプロセス-地域保険活動と行政、消費者保護.

    二宮利治

    令和健康科学大学理学療法学科、作業療法学科  2022.11 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 地域住民における糖尿病と認知症発症の関係:久山町研究<シンポジウム4>糖代謝異常に伴う認知症:最新知見から考察する病態メカニズム.

    二宮利治

    第41回日本認知症学会学術集会・第37回日本老年精神医学会  2022.11 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京都   Country:Japan  

  • <シンポジウム18>本邦における認知症コホート研究の最前線.

    二宮利治

    第41回日本認知症学会学術集会・第37回日本老年精神医学会  2022.11 

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    Event date: 2022.12

    Language:Japanese  

    Venue:東京都   Country:Japan  

  • <シンポジウム48>生活習慣介入によるAD予防のエビデンス.

    二宮利治

    第41回日本認知症学会学術集会・第37回日本老年精神医学会  2022.11 

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    Event date: 2022.12

    Language:Japanese  

    Venue:東京都   Country:Japan  

  • 疫学-疫学調査の概要、疾病の分類、疾病量の把握、疫学の方法.

    二宮利治

    令和健康科学大学理学療法学科、作業療法学科  2022.11 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 各領域での中性脂肪治療の現状と今後の展開.

    二宮利治

    福岡動脈硬化フォーラム2022  2022.9 

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    Event date: 2022.11

    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 地域住民剖検例における血清NT-proBNP値と腎組織所見との関連:久山町研究<ポスター>.

    佐々木峻也、丸本裕和、秦 淳、坪井伸夫、小田義直、北園孝成、横尾 隆、二宮利治

    第65回日本腎臓学会学術総会  2022.6 

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    Event date: 2022.11

    Language:Japanese  

    Venue:神戸市   Country:Japan  

  • 慢性疼痛を有する地域住民における、心拍変動で評価した自律神経機能低下と日常生活動作における自覚・他覚症候の有無の関係

    藤本侑里、柴田舞欧、山浦 健、細井昌子、二宮利治

    日本麻酔科学会第69回学術集会  2022.6 

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    Event date: 2022.11

    Language:Japanese  

    Venue:神戸市   Country:Japan  

  • 地域住民剖検例における皮質領域別の腎組織所見:久山町研究.

    丸本裕和、佐々木峻也、秦 淳、坪井伸夫、小田義直、北園孝成、横尾 隆、二宮利治

    第65回日本腎臓学会学術総会  2022.6 

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    Event date: 2022.11

    Language:Japanese  

    Venue:神戸市   Country:Japan  

  • 地域住民における認知症コホート研究:久山町研究.

    二宮利治

    社内講演会  2022.8 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 地域住民における動脈硬化性疾患のリスク評価:久山町研究.

    二宮利治

    動脈硬化性疾患を考える  2022.8 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:WEB   Country:Japan  

  • 健康長寿における食事の重要性:久山町研究.

    二宮利治

    2022年度NR・サプリメントアドバイザーレベルアップセミナー、Web  2022.9 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:WEB オンデマンド配信   Country:Japan  

  • 高尿酸血症と慢性腎臓病:久山町研究の成績を中心に.

    二宮利治

    第5回福井消化器・脳神経合同講演会、福井市、2022.9  2022.9 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福井市   Country:Japan  

  • Alexithymia and incident chronic pain over 5 years in community dwelling Japanese population: the Hisayama Study. International conference

    Shibata M, Hosoi M, Hirabayashi N, Morisaki Y, Anno K, Yoshida D, Hata J, Ninomiya T, Sudo N

    26th World congress of the international college of psychosomatic medicine,  2022.9 

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    Event date: 2022.11

    Language:English  

    Venue:Rochester, N.Y, U.S.A,   Country:Japan  

  • Association between frequency of social contact and brain atrophy in community-dwelling older people: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) study. International conference

    Hirabayashi N, Honda T, Hata J, Furuta Y, Shibata M, Ohara T, Tatewaki Y, Taki Y, Sudo N, Ninomiya T, on the behalf of JPSC-AD study group

    26th World congress of the international college of psychosomatic medicine,  2022.9 

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    Event date: 2022.11

    Language:English  

    Venue:Rochester, N.Y, U.S.A,   Country:Japan  

  • 久山町研究の成果からみた認知症リスク低減の可能性.

    二宮利治

    第49回農芸化学「化学と生物」シンポジウム  2022.9 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都市   Country:Japan  

  • 日本人を対象とした動脈硬化性疾患の新しい発症リスク予測モデル:久山町研究<シンポジウム11>21世紀の冠動脈疾患の予防:リスクスコアや新たな検査・薬剤をどう使いこなすか.

    秦 淳、本田貴紀、陳 三妹、二宮利治

    第70回日本心臓病学会学術集会  2022.9 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都市   Country:Japan  

  • 地域住民を対象とした生活習慣病の疫学研究:久山町研究.~腎・尿路結石の調査成績も含めて~.

    二宮利治

    日本尿路結石症学会第32回学術集会  2022.7 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • 私の歩んできた臨床・疫学研究の道.

    二宮利治

    第1回臨床研究てらこ屋 in HaKata  2022.7 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • 地域住民における認知症コホート研究:久山町研究.

    二宮利治

    第57回JA共済医学研究会、熊本市、2022.7  2022.7 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:熊本市   Country:Japan  

  • 脳卒中の危険因子とその予防<シンポジウム1>脳心腎臓血管病の予防.

    秦 淳、二宮利治

    第54回日本動脈硬化学会総会・学術集会  2022.7 

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    Event date: 2022.9

    Language:Japanese  

    Venue:久留米市   Country:Japan  

  • 地域住民における動脈硬化性疾患の疫学研究:久山町研究.

    二宮利治

    第54回日本動脈硬化学会総会・学術集会  2022.7 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:久留米市   Country:Japan  

  • 動脈硬化性疾患とその評価・治療・予防_疫学研究・観察研究2.

    二宮利治

    第54回日本動脈硬化学会総会・学術集会  2022.7 

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    Event date: 2022.9

    Language:Japanese  

    Venue:久留米市   Country:Japan  

  • 循環器疾患領域におけるゲノム疫学研究.

    二宮利治

    第54回日本動脈硬化学会総会・学術集会  2022.7 

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    Event date: 2022.9

    Language:Japanese  

    Venue:久留米市   Country:Japan  

  • 地域住民における動脈硬化性疾患発症のリスク予測モデルと「久山町スコア」の作成:久山町研究.

    本田貴紀、陳 三妹、秦 淳、吉田大悟、平川洋一郎、古田芳彦、柴田舞欧、坂田智子、北園孝成、二宮利治

    第54回日本動脈硬化学会総会・学術集会  2022.7 

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    Event date: 2022.9

    Language:Japanese  

    Venue:久留米市   Country:Japan  

  • 地域高齢者における交流頻度と脳萎縮の関連:JPSC-AD研究.

    平林直樹、本田貴紀、秦 淳、古田芳彦、柴田舞欧、小原知之、須藤信行、二宮利治

    第63回日本心身医学会総会ならびに学術講演会  2022.6 

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    Event date: 2022.7

    Language:Japanese  

    Venue:千葉市   Country:Japan  

  • 高血圧、ナトリウム、カリウム摂取.

    二宮利治

    第58回日本循環器病予防学会  2022.6 

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    Event date: 2022.7

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 日本人地域住民におけるMetabolically healthy obesity と心血管病発症の関連:久山町研究.

    東岡真由、秦 淳、平川洋一郎、坂田智子、本田貴紀、大澤春彦、二宮利治

    第58回日本循環器病予防学会  2022.6 

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    Event date: 2022.7

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 認知症予防における食事の重要性:久山町研究<シンポジウム10>臓器終末像予防の為の健康寿命の延伸に向けた栄養.

    二宮利治

    第76回日本栄養・食糧学会大会  2022.6 

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    Event date: 2022.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸市   Country:Japan  

  • 地域高齢住民における大脳白質病変および全脳容積低下が認知症発症に及ぼす影響:久山町研究.

    中澤太郎、小原知之、平林直樹、古田芳彦、秦 淳、柴田舞欧、本田貴紀、北園孝成、中尾智博、二宮利治

    第118回日本精神神経学会学術総会  2022.6 

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    Event date: 2022.7

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 地域住民における血清メチオニン代謝産物濃度と認知症発症および死亡リスクの関連:久山町研究.

    三原 茜、小原知之、秦 淳、陳 三妹、本田貴紀、Sonam Tamrakar、伊佐亜希子、王 冬梅、清水邦義、片倉喜範、中尾智博、北園孝成、二宮利治

    第118回日本精神神経学会学術総会  2022.6 

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    Event date: 2022.7

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 高齢者保健.

    二宮利治

    原看護専門学校講義  2022.5 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 生活習慣と認知症 久山町研究の成績より.

    二宮利治

    共生社会の実現に向けた認知症施策推進議員連盟第三回総会  2022.3 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web   Country:Japan  

  • Risk prediction model for incident atrial fibrillation in a general Japanese population: the Hisayama Study.

    Hata J, Nagata T, Sakata S, Oishi E, Furuta Y, Hirakawa Y, Honda T, Yoshida D, Kitazano T, Ninomiya T

    第86回日本循環器学会学術集会  2022.3 

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    Event date: 2022.6

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 公衆衛生の歴史とその概念.

    二宮利治

    原看護専門学校講義  2022.4 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:Web   Country:Japan  

  • 疫学.

    二宮利治

    原看護専門学校講義  2022.4 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 現在の公衆衛生のシステムと政策.

    二宮利治

    原看護専門学校講義  2022.4 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 公衆衛生活動のプロセス.

    二宮利治

    原看護専門学校講義  2022.5 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 地域住民を対象とした認知症の疫学調査.

    二宮利治

    九州大学歯学部講義  2022.5 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:WEB   Country:Japan  

  • 疫学研究から見た認知症予防.

    二宮利治

    第9回Hyogo Expert Forum for Diabetic Medicine  2021.4 

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    Event date: 2022.5

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Web   Country:Japan  

  • データ連携最前線.

    二宮利治

    弘前大学COIヘルシーエイジング・イノベーションサミット2022  2022.2 

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    Event date: 2022.4

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 血清グリコアルブミン値と心血管病発症との関係:久山町研究<シンポジウム4>大規模臨床研究からのエビデンス.

    二宮利治

    第56回糖尿病学の進歩  2022.2 

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    Event date: 2022.4

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域高齢住民における頭蓋内脳動脈瘤の有病率と発症率:久山町研究.

    古田芳彦、秦 淳、中西泰之、本田貴紀、脇坂義信、吾郷哲朗、北園孝成、二宮利治

    第47回日本脳卒中学会学術集会  2022.2 

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    Event date: 2022.4

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 久山町研究から見た動脈硬化のリスク評価と管理.

    二宮利治

    第22回動脈硬化教育フォーラム  2022.2 

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    Event date: 2022.4

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域一般住民における緑内障に関与する因子:久山町研究<シンポジウム8>コホート研究から探る緑内障に関与する因子.

    藤原康太、二宮利治、園田康平

    第126回日本眼科学会総会  2022.4 

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    Event date: 2022.4 - 2021.4

    Language:Japanese  

    Venue:大阪市   Country:Japan  

  • 糖尿病と認知症の地域疫学研究:久山町研究<シンポジウム4>糖尿病と認知機能障害.

    小原知之、二宮利治

    第63回日本老年医学会学術集会  2021.11 

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    Event date: 2022.3

    Language:Japanese  

    Venue:Web   Country:Japan  

  • アルツハイマー型認知症の血管性危険因子の検討:久山町研究<シンポジウム21>認知機能障害と脳卒中.

    小原知之、二宮利治

    第46回日本脳卒中学会  2021.3 

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    Event date: 2022.3

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 脳卒中発症の危険因子としてのバイオマーカー:久山町研究<シンポジウム10>ビッグデータを活用した脳卒中の医療・医学.

    秦 淳、二宮利治

    第46回日本脳卒中学会  2021.3 

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    Event date: 2022.3

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 脳卒中初発後の再発率・死亡率の時代的推移:久山町研究.

    中西泰之、秦 淳、古田芳彦、吉田大悟、本田貴紀、脇坂義信、吾郷哲朗、北園孝成、二宮利治

    第46回日本脳卒中学会  2021.3 

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    Event date: 2022.3

    Language:Japanese  

    Venue:Web   Country:Japan  

  • Alzheime病と心TTRアミロイドーシスの関連性の病理学的検討.

    濱﨑英臣、司城昌大、本田裕之、二宮利治、山田裕一、小田義直、岩城 徹

    第62回日本神経病理学会総会学術研究会  2021.5 

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    Event date: 2022.3

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 慢性腎臓病と認知症<合同企画シンポジウム5>透析患者における認知症の予防と対策.

    小原知之、二宮利治

    第66回日本透析医学会学術集会・総会  2021.6 

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    Event date: 2022.3

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域高齢者における慢性疼痛と脳領域別萎縮の関連.

    浅田雅子、柴田舞欧、平林直樹、小原知之、山浦 健、二宮利治

    日本麻酔科学会第68回学術集会  2021.6 

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    Event date: 2022.3

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域高齢住民における認知症の実態とその危険因子・防御因子:久山町研究<シンポジウム12>本邦の高齢者を対象とする疫学研究の結果から、認知症施策の在り方を考える.

    小原知之、二宮利治

    第117回日本精神神経学会学術総会  2021.9 

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    Event date: 2022.3

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 糖尿病の地域疫学研究:久山町研究.

    二宮利治

    北九州糖尿病研究会第600回記念講演会  2022.1 

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    Event date: 2022.2

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:北九州   Country:Japan  

  • 血清Mac-2結合蛋白糖鎖装飾異性体(M2BPGi)と糖尿病発症の関連:久山町研究.

    東岡真由、平川洋一郎、吉成匡人、本田貴紀、吉田大悟、秦 淳、大澤春彦、二宮利治

    第63回日本糖尿病学会年次学術集会  2020.10 

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    Event date: 2022.2

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域一般住民における家族機能レベルと抑うつ症状の関連:久山町研究.

    長澤 史、柴田舞欧、吉田大悟、秦 淳、二宮利治

    第80回日本公衆衛生学会総会  2021.12 

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    Event date: 2022.2

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 研究成果:久山町研究.

    二宮利治

    令和3年度弘前COI事後評価ヒアリング  2021.12 

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    Event date: 2022.2

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 高血圧と脳心血管イベントの疫学~久山町研究を中心に~. Invited

    二宮利治

    大塚製薬社内研修会  2021.12 

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    Event date: 2022.2

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 臨床研究における解析の進め方.

    二宮利治

    第3回臨床研究と統計を考える会  2021.12 

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    Event date: 2022.2

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:Web   Country:Japan  

  • 地域住民における血清NT-proBNP測定の意義:久山町研究.

    二宮利治

    日本総合健診医学会第50回大会  2022.1 

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    Event date: 2022.2

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Japan  

  • 健診データを用いた臨床研究の実際.

    二宮利治

    日本総合健診医学会第50回大会  2022.1 

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    Event date: 2022.2

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 中年期地域住民のおける要介護認定の危険因子の探索:福岡市地域包括ケア情報プラットフォームデータによる縦断的検討.

    二宮利治、木村安美、本田貴紀、古田芳彦、吉田大悟、秦 淳

    日本総合健診医学会第50回大会  2022.1 

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    Event date: 2022.2

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 活動的な通勤および通勤形態と糖尿病発症リスクの関連:久山町研究.

    本田貴紀、平川洋一郎、、秦 淳、陳 三妹、柴田舞欧、坂田智子、古田芳彦、東岡真由、大石絵美、北園孝成、二宮利治

    第32回日本疫学会学術総会  2022.1 

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    Event date: 2022.2

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 連続剖検症例における被殻のtau・Aβ免疫組織化学染色の定量解析:久山町研究.<ポスター>

    濱﨑英臣、本田裕之、岡本 剛、二宮利治、鈴木 諭、岩城 徹

    第60回日本神経病理学会総会学術研究会  2019.7 

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    Event date: 2022.2

    Language:Japanese  

    Venue:名古屋市   Country:Japan  

  • Putaminal tau pathology in the aging Japanese population: the Hisayama Study. International conference

    Hamasaki H, Honda H, Okamoto T, Suzuki OS, Ninomiya T, Iwaki T

    The 19th International Congress of Neuropathology  2018.9 

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    Event date: 2022.2

    Language:English  

    Venue:Tokyo   Country:Japan  

  • 海馬の異常リン酸化タウタンパク蓄積の数理形態学的解析: 久山町研究における近年の動向.

    濱﨑英臣, 本田裕之, 岡本 剛, 二宮利治, 清原 裕, 岩城徹

    第57回日本神経病理学会総会学術研究会  2016.6 

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    Event date: 2022.2

    Language:Japanese  

    Venue:弘前市   Country:Japan  

  • 地域一般住民における慢性疼痛の有症率と定義の検討:久山町研究.

    柴田舞欧、細井昌子、二宮利治

    第80回日本公衆衛生学会総会  2021.12 

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    Event date: 2021.12 - 2022.2

    Language:Japanese  

    Venue:Web   Country:Japan  

  • Serum uric acid levels and nephrosclerosis in a population-based autopsy study: the Hisayama Study. International conference

    Maki K, Hata J, Sakata S, Furuta Y, Oishi E, Nakano T, Oda Y, Kitazono T, Ninomiya T

    American Society of Nephrology Kidney Week 2021、  2021.11 

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    Event date: 2021.12

    Language:English  

    Venue:Web   Country:Japan  

  • 地域一般住民における失感情症が慢性疼痛発症リスクに及ぼす影響:久山町研究.

    柴田舞欧、細井昌子、平林直樹、森崎悠紀子、安野広三、吉田大悟、秦 淳、二宮利治、須藤信行

    第62回日本心身医学会総会ならびに学術講演会  2021.7 

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    Event date: 2021.12

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域一般住民において家庭機能低下は抑うつ症状に関連する:久山町研究.

    長澤 史、柴田舞欧、平林直樹、陳 三妹、吉田大悟、秦 淳、須藤信行、二宮利治

    第28回日本未病学会学術総会  2021.11 

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    Event date: 2021.12

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 生活習慣と認知症:久山町研究.

    二宮利治

    第一薬科大学看護学部講義  2021.11 

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    Event date: 2021.12

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 地域一般住民における心理社会的因子と慢性疾患の関連:久山町研究.<シンポジウム1>心理社会的側面からの住民コホート研究.

    柴田舞欧、平林直樹、細井昌子、二宮利治、須藤信行

    第28回日本行動医学会学術総会  2021.11 

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    Event date: 2021.12

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 認知症予防や健康長寿における食事の重要性:久山町研究の成績より.

    二宮利治

    バイオ戦略「地域バイオコミュニティ」認定キックオフイベント  2021.11 

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    Event date: 2021.12

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 認知症発症に関わる生活習慣病について:久山町研究の成績を中心に<シンポジウム2>多因子生活習慣介入による認知症予防.

    二宮利治

    第40回日本認知症学会学術総会  2021.11 

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    Event date: 2021.12

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域疫学研究の実際:久山町研究.

    二宮利治

    第一薬科大学看護学部講義  2021.11 

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    Event date: 2021.12

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 失感情症は慢性疼痛発症リスク上昇に関連する:久山町研究.

    柴田舞欧、二宮利治、平林直樹、森崎悠紀子、安野広三、吉田大悟、秦 淳、須藤信行、細井昌子

    第14回日本運動器疼痛学会  2021.11 

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    Event date: 2021.12

    Language:Japanese  

    Venue:Web   Country:Japan  

  • <ランチョンセミナー2>高血圧と未病.

    二宮利治

    第28回日本未病学会学術総会  2021.11 

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    Event date: 2021.12

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:大阪市   Country:Japan  

  • 糖尿病合併症とグリコアルブミン(GA)について:久山町研究<共催セミナー2>.

    二宮利治

    第45回日本血液事業学会総会  2021.11 

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    Event date: 2021.12

    Language:Japanese  

    Venue:Web   Country:Japan  

  • Association of preserved ratio impaired spirometry with mortality risk: the Hisayama Study. International conference

    Washio Y, Sakata S, Fukuyama S, Sasaki T, Honda T, Kan-o K, Hata J, Kitazono T, Matsumoto K, Ninomiya T

    The 25th Congress of the Asian Pacific Society of Respirology  2021.11 

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    Event date: 2021.12

    Language:English  

    Venue:Web   Country:Japan  

  • Histological diabetic nephropathy in autopsied diabetic cases with normoalbuminuria from a Japanese community-based study: the Hisayama Study. International conference

    Sasaki T, Nakagawa K, Hata J, Hirakawa Y, Shibata M, Nakano T, Tsuboi N, Oda Y, Kitazono T, Yokoo T, Ninomiya T

    American Society of Nephrology Kidney Week 2021  2021.11 

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    Event date: 2021.12

    Language:English  

    Venue:Web   Country:Japan  

  • 高齢者保健.

    二宮利治

    原看護専門学校  2021.10 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:Web   Country:Japan  

  • 日本人地域住民における高血圧管理状況の時代的推移:久山町研究.

    大石絵美、坂田智子、秦 淳、平川洋一郎、後藤健一、北園孝成、二宮利治

    第43回日本高血圧学会総会  2021.9 

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    Event date: 2021.11

    Language:Japanese  

    Venue:Web   Country:Japan  

  • Community-based cohort study for diabetes and dementia: the Hisayama Study.

    二宮利治

    JICA青年研修、Web、2021.10  2021.10 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:Web   Country:Japan  

  • 地域高齢者における血清NT-proBNPと脳灰白質萎縮パターンとの関連:久山町研究.

    平林直樹、秦 淳、小原知之、古田芳彦、柴田舞欧、山下典生、北園孝成、須藤信行、二宮利治

    日本臨床疫学会第4回年次学術大会  2021.10 

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    Event date: 2021.11

    Language:Japanese  

    Venue:東京   Country:Japan  

  • <ランチタイムセミナー3>CKD領域におけるグローバルコホート研究の展開.

    二宮利治

    日本臨床疫学会第4回年次学術大会  2021.10 

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    Event date: 2021.11

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 疾病予防におけるEPAの重要性~久山町研究の成績より~.

    二宮利治

    第11回Pharmacy Seminar  2021.10 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • Hypercholesterolemia as a risk factor for stroke incidence and recurrence in Japan: finding from the Hisayama Study and the Fukuoka Stroke Registry. International conference

    Hata J, Matsuo R, Ninomiya T, Kamouchi M, Kitazono T

    第19回国際動脈硬化学会議、Web、2021.10  2021.10 

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    Event date: 2021.11

    Language:Japanese  

    Venue:Web   Country:Japan  

  • Lifetime risk of cardiovascular disease death according to composite risk factors: A pooled analysis of data from the evidence for cardiovascular prevention from observational cohorts in Japanese Study. International conference

    Imai Y, Murakami Y, Ninomiya T, Miyamoto Y, Yamada M, Ishikawa S, Sakata K, Iso H, Nakagawa H, Ohkubo T, Tamakoshi A, Saitoh S, Miura K, Ueshima H, Okamura T

    第19回国際動脈硬化学会議、Web、2021.10  2021.10 

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    Event date: 2021.11

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 生活習慣と認知症~60周年を迎えた久山町研究から~.

    二宮利治

    久山町生活習慣病予防健診60周年記念講演  2021.10 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:糟屋郡   Country:Japan  

  • エンレストを高血圧治療にどのように役立てるか.

    二宮利治

    高血圧 National Symposium  2021.10 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:Web   Country:Japan  

  • 地域住民における高血圧治療の現状と課題.

    二宮利治

    高血圧 National Symposium  2021.10 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:Web   Country:Japan  

  • 日本人地域住民における睡眠時家庭血圧値と心血管病発症との関連:久山町研究.

    坂田智子、大石絵美、秦 淳、平川洋一郎、北園孝成、二宮利治

    第43回日本高血圧学会総会  2021.10 

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    Event date: 2021.11

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域一般住民における家庭血圧日間変動と慢性腎臓病発症との関連:久山町研究.

    佐々木峻也、坂田智子、大石絵美、秦 淳、坪井伸夫、北園孝成、横尾 隆、二宮利治

    第43回日本高血圧学会総会  2021.10 

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    Event date: 2021.11

    Language:Japanese  

    Venue:Web   Country:Japan  

  • <シンポジウム7>大規模医療データベースを活用した臨床疫学研究.

    二宮利治

    <座長>  2021.10 

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    Event date: 2021.11

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域住民における脂質代謝異常と動脈硬化性疾患の関係:久山町研究<シンポジウム4>わが国の代表的な循環器コホート研究の最新情報.

    二宮利治

    第43回日本高血圧学会総会  2021.10 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:Web   Country:Japan  

  • 地域高齢住民における歩行速度と認知症発症および脳容積との関連:久山町研究.

    多治見昂洋、古田芳彦、平林直樹、本田貴紀、秦 淳、小原知之、柴田舞欧、中尾智博、北園孝成、中島康晴、二宮利治

    第36回日本整形外科学会基礎学術集会  2021.10 

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    Event date: 2021.11

    Language:Japanese  

    Venue:伊勢市   Country:Japan  

  • 血清リポ多糖結合タンパク質(LBP)と生活習慣病の関係:久山町研究<特別企画2>データ連携最前線.

    二宮利治

    弘前大学COIヘルシーエイジング・イノベーションフォーラム2021  2021.10 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web   Country:Japan  

  • 地域住民における認知症コホート研究:久山町研究.<シンポジウム>認知症予防の最前線-認知症の一次、二次、三次予防の重要性-.

    二宮利治

    医療科学研究所シンポジウム2021  2021.10 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 認知症予防や健康長寿における食事の重要性:久山町研究の成績を中心に.

    二宮利治

    アクティブシニア「食と栄養」研究会食品開発展2021、東京、2021.10  2021.10 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:東京   Country:Japan  

  • 疫学.

    二宮利治

    原看護専門学校  2021.9 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:Web   Country:Japan  

  • 地域住民における緑内障の有病率:久山町研究.

    藤原康太, 安田美穂, 秦淳, 中野聡子, 中室隆子, 村上祐介, 岩瀬愛子, 新家眞, 田原昭彦, 久保田敏昭, 吉冨健志, 二宮利治, 園田康平,

    第124回日本眼科学会総会  2020.4 

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    Event date: 2021.10

    Language:Japanese  

    Venue:Web   Country:Japan  

  • Community-based cohort study for diabetes: the Hisayama Study. International conference

    Ninomiya T

    The 5th Academic Forum on Health Management in Five Provinces and One City of Central China  2021.5 

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    Event date: 2021.10

    Language:English  

    Venue:Web   Country:Japan  

  • 地域一般住民におけるPreserved Ratio Impaired Spirometry と死亡リスクの関連:久山町研究.

    鷲尾康圭、坂田智子、福山 聡、佐々木峻也、本田貴紀、神尾敬子、秦 淳、北園孝成、松元幸一郎、二宮利治

    第114回呼吸生理フォーラム、第94回閉塞性肺疾患研究会  2021.7 

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    Event date: 2021.10

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域高齢住民における脳部位別の灰白質萎縮が認知症発症に及ぼす影響:久山町研究.

    中澤太郎、小原知之、平林直樹、古田芳彦、秦 淳、柴田舞欧、本田貴紀、北園孝成、中尾智博、二宮利治

    第43回日本生物学的精神医学会、第51回日本神経精神薬理学会  2021.7 

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    Event date: 2021.10

    Language:Japanese  

    Venue:京都市   Country:Japan  

  • 地域住民の連続解剖例における前立腺癌の頻度の時代的推移:久山町研究.

    二宮利治

    第30回日本腎泌尿器疾患予防医学研究会  2021.7 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • 糖尿病の地域疫学研究の実際:久山町研究.

    二宮利治

    Scientific Exchange Meeting  2021.7 

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    Event date: 2021.10

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 糖尿病と癌の関係:久山町研究の成績を中心に.

    二宮利治

    第17回九州臨床糖尿病医会WEBセミナー  2021.7 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web   Country:Japan  

  • 公衆衛生の歴史とその概念.

    二宮利治

    原看護専門学校  2021.8 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:Web   Country:Japan  

  • 久山町研究の歴史と現在の取り組み.

    二宮利治

    第35回日本下垂体研究会学術集会  2021.8 

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    Event date: 2021.10

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 生活習慣病の予防で認知症・要介護のリスクを減らす!~60周年を迎えた久山町研究から~.

    二宮利治

    第4回CareTEX福岡’21  2021.9 

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    Event date: 2021.10

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 公衆衛生活動のプロセス.

    二宮利治

    原看護専門学校  2021.9 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:Web   Country:Japan  

  • 地域高齢住民における脳部位別灰白質容積低下と認知症発症の関連:久山町研究.

    中澤太郎、小原知之、平林直樹、古田芳彦、秦 淳、柴田舞欧、本田貴紀、北園孝成、中尾智博、二宮利治

    第117回日本精神神経学会学術総会  2021.9 

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    Event date: 2021.10

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 現在の公衆衛生のシステムと政策.

    二宮利治

    原看護専門学校  2021.9 

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    Event date: 2021.10

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:Web   Country:Japan  

  • 糖尿病と乳頭周囲網膜神経線維層厚との関連:久山町研究,

    藤原康太, 安田美穂, 秦淳, 橋本左和子, 上田瑛美, 吉冨健志, 岩瀬愛子, 新家眞, 二宮利治, 園田康平,

    日本緑内障学会  2018.9 

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    Event date: 2021.10

    Language:Japanese  

    Venue:新潟   Country:Japan  

  • 糖尿病と癌の関係:久山町研究の成績を中心に.

    二宮利治

    第17回九州臨床糖尿病医会WEBセミナー、Web、  2021.7 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web   Country:Japan  

  • 地域高齢住民における脳部位別の肺白質萎縮が認知症発症に及ぼす影響:久山町研究.

    中澤太郎、小原知之、平林直樹、古田芳彦、秦 淳、柴田舞欧、本田貴紀、北園孝成、中尾智博、二宮利治

    第43回日本生物学的精神医学会、第51回日本神経精神薬理学会  2021.7 

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    Event date: 2021.9

    Language:Japanese  

    Country:Japan  

  • 地域住民の連続解剖例における前立腺癌の頻度の時代的推移:久山町研究.

    二宮利治

    第30回日本腎泌尿器疾患予防医学研究会  2021.7 

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    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • 生活習慣病と認知症の関係:久山町研究.

    二宮利治

    第184回分泌セミナー  2021.6 

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    Event date: 2021.7

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域住民における発酵乳製品の摂取と歯の喪失の関係.

    古田美智子、竹内研時、竹下 徹、須磨紫乃、影山伸哉、朝川美加李、嶋﨑義浩、二宮利治、山下喜久

    第70回日本口腔衛生学会総会  2021.5 

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    Event date: 2021.7

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 臨床研究の進め方.

    二宮利治

    第2回臨床研究と統計を考える会  2021.6 

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    Event date: 2021.7

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域住民の剖検例における血清NT-proBNP値と心筋線維化に関する病理組織学的検討:久山町研究.

    佐々木峻也、伊豆丸堅祐、秦 淳、坂田智子、大石絵美、永田拓也、坪井伸夫、小田義直、北園孝成、横尾 隆、二宮利治

    第130回日本循環器学会九州地方会  2021.6 

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    Event date: 2021.7

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 糖尿病と認知症の疫学:久山町研究<シンポジウム1>生活習慣病と認知症.

    二宮利治

    第21回日本抗加齢医学会総会  2021.6 

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    Event date: 2021.7

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 久山町研究におけるCDKの最近の知見.

    二宮利治

    高齢者社会とまちづくりを考える  2021.6 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web   Country:Japan  

  • Association between albuminuria and diabetic nephropathy lesions in autopsy cases with diabetes mellitus: the Hisayama Study.

    Sasaki T、Nakagawa K、Hata J、Nakano T、Tsuboi N、Yokoo T、Oda Y、Kitazono T、Ninomiya T

    第64回日本腎臓学会学術総会  2021.6 

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    Event date: 2021.7

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 糖尿病性腎臓病と心血管病の関係:国内外の臨床・疫学研究の成績より<シンポジウム18>糖尿病における心腎連関-最新知見が語る真実とは-(日本糖尿病学会合同企画).

    二宮利治

    第64回日本腎臓学会学術総会  2021.6 

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    Event date: 2021.7

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域住民の剖検例における血清尿酸値と腎硬化症との関連:久山町研究.

    牧 建次、秦 淳、中野敏昭、小田義直、北園孝成、二宮利治

    第64回日本腎臓学会学術総会  2021.6 

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    Event date: 2021.7

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域高齢者における尿中アルブミンと脳萎縮・大脳白質病変の関連:JPSC-AD研究.

    山﨑景介、秦 淳、小原知之、柴田舞欧、古田芳彦、平林直樹、瀧 靖之、二宮利治

    第64回日本腎臓学会学術総会  2021.6 

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    Event date: 2021.7

    Language:Japanese  

    Venue:Web   Country:Japan  

  • CKD(臨床)2.<司会>

    二宮利治、田中健一

    第64回日本腎臓学会学術総会  2021.6 

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    Event date: 2021.7

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域住民における認知症の疫学研究:久山町研究. Invited

    二宮利治

    2021年度名城大学薬学部講義  2021.6 

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    Event date: 2021.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:Web   Country:Japan  

  • 地域高齢住民における魚介類摂取量と認知症発症の関連:久山町研究.

    陳 三妹、本田貴紀、小原知之、秦 淳、吉田大悟、平川洋一郎、柴田舞欧、坂田智子、中尾智博、二宮利治

    第57回日本循環器予防学会学術集会  2021.6 

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    Event date: 2021.7

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 久山町研究を基盤とした脳梗塞のゲノム疫学研究<シンポジウム2>ゲノム情報を循環器病予防にどう活かすか?.

    秦 淳、二宮利治

    第57回日本循環器予防学会学術集会  2021.6 

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    Event date: 2021.7

    Language:Japanese  

    Venue:Web   Country:Japan  

  • <パネルディスカッション>リスク因子のモリタリングはこう変わる.<座長>

    大石 充、二宮利治

    第57回日本循環器予防学会学術集会  2021.6 

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    Event date: 2021.7

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 久山町研究~60年目を迎えて~.<教育講演>

    二宮利治

    第70回日本医学検査学会  2021.5 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web   Country:Japan  

  • 食事パターンおよび血中β-アラニン濃度と認知症リスクの関連:久山町研究.<企業協賛シンポジウム2>畜産学分野におけるメタボロミクスの可能性.

    二宮利治

    日本畜産学会第128回大会  2021.3 

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    Event date: 2021.6

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 脂質代謝異常と心血管病-久山町研究-.

    二宮利治

    高中性脂肪血症の治療意義を再考する会<特別講演>  2021.3 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • 高尿酸血症とCDK:久山町研究の成績から考える.

    二宮利治

    高尿酸血症リモートフォーラム  2021.3 

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    Event date: 2021.6

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域疫学研究から見た認知症予防の可能性:久山町研究.

    二宮利治

    Diabetes Update Meeting in Kimitsu  2021.4 

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    Event date: 2021.6

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 疫学研究から見た認知症予防

    二宮利治

    第9回Hyogo Expert Forum for Diabetic Medicine  2021.4 

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    Event date: 2021.6

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 疾病予防におけるEPAの重要性~久山町研究の成績より~.<サテライト講演>

    二宮利治

    EPAネットフォーラム  2021.5 

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    Event date: 2021.6

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 日本人地域一般住民における脈絡膜厚と近視性黄斑症の関連:久山町研究.

    上田瑛美、安田美穂、藤原康太、橋本左和子、中村駿、大野京子、秦 淳、石橋達朗、二宮利治、園田康平

    第3回日本近視学会総会  2021.5 

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    Event date: 2021.6

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域住民を対象とした認知症の疫学調査.

    二宮利治

    2021年度九州大学歯学部歯科全身管理学講義  2021.5 

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    Event date: 2021.6

    Language:Japanese  

    Country:Japan  

  • 糖尿病と認知症の地域疫学研究:久山町研究.

    二宮利治

    第55回糖尿病学の進歩、Web、  2021.3 

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    Event date: 2021.5

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 健康管理アプリを活用したウォーキングイベントの開催とその効果

    石田有紀、吉田大悟、二宮利治

    第9回日本公衆衛生看護学会学術集会、Web  2021.1 

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    Event date: 2021.5

    Language:Japanese  

    Venue:Web   Country:Japan  

  • <シンポジウム10>ビッグデータを活用した脳卒中の医療・医学.

    二宮利治

    第46回日本脳卒中学会、  2021.3 

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    Event date: 2021.5

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 生活習慣病と認知症:糖尿病対策の重要性.

    二宮利治

    第2回岡山糖尿病カンファレンス、Web  2021.3 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:Web   Country:Japan  

  • 地域疫学研究から見た認知症予防.<特別企画3>データ連携最前線.

    二宮利治

    弘前大学COIヘルシーエイジング・イノベーションサミット2021  2021.2 

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    Event date: 2021.4

    Language:Japanese  

    Venue:Web   Country:Japan  

  • N-terminal pro-B-type natriuretic peptide can predict new-onset atrial fibrillation in a general population: the Hisayama Study.

    Nagata T, Hata J, Sakata S, Oishi E, Hirakawa Y, Ide T, Kitazono T, Tsutsui H, Ninomiya T

    第84回日本循環器学会学術集会、Web、2020.7  2020.7 

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    Event date: 2021.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web   Country:Japan  

  • 血清LBPとメタボリック・シンドローム発症との関連:久山町研究.

    友岡祥子、大石絵美、浅田雅子、秦 淳、和田尚久、二宮利治

    第56回日本循環器病予防学会  2020.12 

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    Event date: 2021.4

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域住民における野菜・果物摂取量と認知症発症との関連の検討:久山町研究.

    木村安美、吉田大悟、小原知之、秦 淳、本田貴紀、柴田舞欧、坂田智子、平川洋一郎、内田和弘、二宮利治

    第31回日本疫学会学術総会  2021.1 

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    Event date: 2021.4

    Language:Japanese  

    Venue:Web   Country:Japan  

  • Association[of serum folate and vitamin B-12 concentrations with all-cause mortality: the Hisayama Study.

    Chen S, Honda T, Hata J, Sakata S, Furuta Y, Yoshida D, Shibata M, Ohara T, Hirakawa Y, Oishi E, Kitazono T, Ninomiya T

    第31回日本疫学会学術総会  2021.1 

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    Event date: 2021.4

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 動脈硬化性心血管疾患発症リスク予測モデルの開発:久山町研究.

    本田貴紀、陳三妹、秦 淳、吉田大悟、平川洋一郎、古田芳彦、柴田舞欧、坂田智子、北園孝成、二宮利治

    第31回日本疫学会学術総会  2021.1 

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    Event date: 2021.4

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域認知症コホート研究:久山町研究およびJPSC-AD研究.<メインシンポジウム>新たな疫学の展開を求めて.

    二宮利治

    第31回日本疫学会学術総会  2021.1 

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    Event date: 2021.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web   Country:Japan  

  • 認知症予防における食事の重要性:久山町研究の成績を中心に.

    二宮利治

    第24回認知症を語る会  2021.2 

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    Event date: 2021.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web   Country:Japan  

  • 良い臨床研究を行うために.

    二宮利治

    第3回初学者のためのCKD臨床研究セミナー@九州大学  2021.2 

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    Event date: 2021.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:Web   Country:Japan  

  • Association between serum homocysteine and risk of dementia inJapanese elderly: the Hisayama Study.‹ポスター›

    Chen S, Honda T, Ohara T, Hata J, Hirakawa Y, Yoshida D, Shibata M, Kitazono T, Ninomiya T

    第30回日本疫学会学術総会  2020.2 

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    Event date: 2021.4

    Language:Japanese  

    Venue:京都市   Country:Japan  

  • 臨床疫学的見地からみた認知症予防の可能性.

    二宮利治

    第39回日本認知症学会学術集会  2021.4 

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    Event date: 2021.4 - 2020.11

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 健康寿命を延ばそう!生活習慣・認知症・ロコモの予防の重要性.

    二宮利治

    福岡市薬剤師会・健康応援薬局研修会  2020.12 

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    Event date: 2021.3

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 高尿酸血症と慢性腎臓病:久山町研究の成績より.

    二宮利治

    福岡SURI研究会  2020.9 

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    Event date: 2021.3

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 血清NT-proBNPと慢性腎臓病発症との関連:久山町研究.

    佐々木峻也、大石絵美、坂田智子、本田貴紀、秦 淳、坪井伸夫、横尾隆、二宮利治

    第63回日本腎臓学会学術総会  2020.9 

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    Event date: 2021.3

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域住民を対象とした大規模認知症コホート研究の展開.

    二宮利治

    第79回日本公衆衛生学会総会  2020.10 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web   Country:Japan  

  • 地域コホート研究の実際:久山町研究を中心に<シンポジウム>フィールドワークとスーパーコンピュータ.

    二宮利治

    京都大学学術情報メディアセンターセミナー  2020.11 

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    Event date: 2021.3

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域一般住民における家族機能と慢性疼痛の関連:久山町研究.

    齊藤貴文、柴田舞欧、平林直樹、森崎悠紀子、安野広三、須藤信行、二宮利治、細井昌子

    第13回日本運動器疼痛学会  2020.11 

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    Event date: 2021.3

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域一般住民における慢性疼痛の定義と有症率の関連:久山町研究.

    柴田舞欧、二宮利治、齊藤貴文、平林直樹、森崎悠紀子、安野広三、須藤信行、細井昌子

    第13回日本運動器疼痛学会  2020.11 

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    Event date: 2021.3

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 生活習慣病と認知症:久山町研究の知見より.

    二宮利治

    東和薬品社内研修会  2020.11 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web   Country:Japan  

  • 地域住民における糖尿病の疫学研究:久山町研究.

    二宮利治

    第5回日本糖尿病・生活習慣病ヒューマンデータ学会年次学術集会  2020.12 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 地域住民における脳関連疾患の疫学:久山町研究.

    二宮利治

    第2回糖尿病カンファレンス~糖尿病と脳卒中にフォーカスして~  2020.12 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web   Country:Japan  

  • 高尿酸血症と慢性腎臓病および心血管病リスク:久山町研究の成績を中心に.

    二宮利治

    福岡循環器Small Meeting  2020.12 

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    Event date: 2021.3

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域住民における生活習慣病と認知症の関係.

    二宮利治

    Academy for Intergrated Patient Centered Care  2020.12 

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    Event date: 2021.3

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 認知症発症リスク予測モデルの開発:久山町研究.

    本田貴紀、小原知之、吉田大悟、平川洋一郎、石田有紀、古田芳彦、大石絵美、坂田智子、柴田舞欧、秦 淳、北園孝成、二宮利治

    第30回日本疫学会学術総会  2020.2 

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    Event date: 2021.3

    Language:Japanese  

    Venue:京都市   Country:Japan  

  • 久山町研究~60年目を迎えて~<シンポジウム7>久山スタディ緑内障検診.

    二宮利治

    第31回日本緑内障学会  2020.10 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:web   Country:Japan  

  • 地域住民における認知症の疫学研究:久山町研究.

    二宮利治

    2020年度名城大学薬学部講義  2020.6 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:Web   Country:Japan  

  • 疫学.

    二宮利治

    原看護専門学校講義  2020.9 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 公衆衛生の歴史とその概念. International conference

    二宮利治

    原看護専門学校講義  2020.9 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • ‹Keynote Speech›Community-based prospective cohort study for dementia: the Hisayama Study.

    二宮利治

    ソウル大学・九州大学ジョイントシンポジウム  2020.9 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:Web、2020.9   Country:Japan  

  • <スポンサードセッション1>

    二宮利治

    第79回日本公衆衛生学会総会、Web、2020.10  2020.10 

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    Event date: 2020.11

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 疫学の視点からみた睡眠障害と認知症発症‹シンポジウム›睡眠障害と認知症.

    小原知之、二宮利治

    第38回日本認知症学会学術集会  2019.11 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京都   Country:Japan  

  • 剖検にて放線菌脳膿瘍と診断しえた超高齢者の一例.

    三原 茜、東岡真由、大石絵美、秦 淳、酒井健司、伊地知佳世、本田裕之、小田義直、二宮利治

    第29回日本老年医学会九州地方会、福岡市、2019.3  2019.3 

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    Event date: 2020.9

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 認知症コホート研究から(1):久山町研究‹シンポジウム›生活習慣・生活習慣病と認知症・アルツハイマー病.

    小原知之、二宮利治

    第116回日本内科学会総会・講演会  2019.4 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋市   Country:Japan  

  • 血清sTREM2と認知症発症の関係:久山町研究‹シンポジウム›アルツハイマー病のバイオマーカー研究と疾患修飾薬開発研究の現在.

    小原知之、二宮利治

    第34回日本老年精神医学会  2019.6 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:仙台市   Country:Japan  

  • 血清sTREM2と認知症発症:久山町研究‹シンポジウム›免疫・炎症と脳・心血管疾患~未病を捉える~.

    小原知之、二宮利治

    第26回日本未病システム学会学術総会、名古屋市、2019.11  2019.11 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋   Country:Japan  

  • 久山町における認知症コホート研究‹シンポジウム›認知症の疫学とコホート研究.

    小原知之、二宮利治

    第38回日本認知症学会学術集会、東京、2019.11  2019.11 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 久山町研究からみたアルツハイマー型認知症の血管性危険因子‹シンポジウム›アルツハイマー病における血管性危険因子.

    小原知之、二宮利治

    第38回日本認知症学会学術集会  2019.11 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 地域一般住民における尿中NT-ProBNPと心血管病の発症の関連:久山町研究.

    山﨑景介、秦 淳、平川洋一郎、坂田智子、古田芳彦、北園孝成、二宮利治

    第45回日本脳卒中学会総会、Web、2020.8-9  2020.8 

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    Event date: 2020.8

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 地域住民における糖尿病、認知症の疫学研究:久山町研究.

    二宮利治

    福岡県臨床化学会学術研究会  2020.2 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 日本人の心血管病と危険因子の変遷-久山町研究から.

    二宮利治

    第53回日本痛風・核酸代謝学会総会  2020.2 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北九州市   Country:Japan  

  • 高尿酸血症と慢性腎臓病・心血管病の関係~久山町研究の成績を中心に~. Invited

    二宮利治

    持田製薬株式会社社員教育  2020.2 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 健康長寿社会の実現を目指した認知症全国調査.

    二宮利治

    なかじまプロジェクト市民公開講座「健康長寿社会をめざした~認知症全国調査と認知症への取り組み~  2020.2 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:七尾市   Country:Japan  

  • 日本人地域一般住民における慢性疼痛の有症率と定義の検討:久山町研究.

    柴田舞欧、細井昌子、平林直樹、齊藤貴文、森崎悠紀子、安野広三、須藤信行、二宮利治

    第59回日本心身医学会九州地方会  2020.2 

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    Event date: 2020.8

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 地域住民における認知症コホート研究:久山町研究.

    二宮利治

    第109回日本病理学会総会  2020.4 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:Web   Country:Japan  

  • 高血圧とCKD~久山町研究の成績を中心に~.

    二宮利治

    Nagasaki Kidney Seminar、Web、2020.6  2020.6 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:長崎市   Country:Japan  

  • 認知症予防における食事および歯科ケアーの重要性:久山町研究.

    二宮利治

    第129回日本補綴歯科学会学術大会、誌上・Web  2020.6 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:Web   Country:Japan  

  • 日本人地域住民における動脈硬化性疾患とその危険因子の推移:久山町研究‹シンポジウム1›動脈硬化のリスク軽減は健康寿命の延伸に貢献したか?.

    秦 淳、二宮利治

    第52回日本動脈硬化学会総会・学術集会、Web  2020.7 

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    Event date: 2020.8

    Language:Japanese  

    Venue:Web   Country:Japan  

  • <シンポジウム1>動脈硬化のリスク軽減は健康寿命の延伸に貢献したか.

    二宮利治

    第52回日本動脈硬化学会総会・学術集会、Web、2020.7  2020.7 

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    Event date: 2020.8

    Language:Japanese  

    Venue:Web   Country:Japan  

  • 生活習慣病と認知症の関係~久山町研究の知見より~.

    二宮利治

    令和元年度温古会研修・講演会  2020.1 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 地域住民における生体成分と認知症発症の関係:久山町研究.

    二宮利治

    福岡県・久留米市地方創生事業成果報告会  2020.1 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • <ワークショップ>お悩み解決!認知症コホート・レジストリ研究の“あるある”.

    二宮利治

    AMEDシンポジウム2019~医療研究が未来を変える~  2019.12 

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    Event date: 2020.7

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域コホート研究の実際:久山町研究. Invited

    二宮利治

    名城大学薬学部3年生講義  2019.5 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:名古屋市   Country:Japan  

  • 久山町研究.

    二宮利治

    第5回九州大学日本橋サテライトセミナー  2019.6 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • A Comparison of the Contributions of Impaired Insulin Secretion and Insulin Resistance to the Development of Type 2 Diabetes in a Japanese Community: the Hisayama Study. International conference

    Yoshinari M, Hirakawa Y, Hata J, Higashioka M, Honda T, Yoshida D, Mukai M, Nakamura U, Kitazono T, Ninomiya T

    The 79th American Diabetes Association Scientific Sessions  2019.6 

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    Event date: 2020.7

    Language:English  

    Venue:San francisco, CA, USA   Country:Japan  

  • Serum Mac-2 Binding Protein Glycosylation Isomer Level and the Risk of Type 2 Diabetes in a Japanese Community: the Hisayama Study. International conference

    Higashioka M, Hirakawa Y, Yoshinari M, Honda T, Sakata S, Shibata M, Yoshida D, Hata J, Kitazono T, Osawa H, Ninomiya T

    The 79th American Diabetes Association Scientific Sessions  2019.6 

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    Event date: 2020.7

    Language:Others  

    Venue:,San francisco, CA, USA,   Country:Japan  

  • 高比重リポ蛋白(High-density lipoprotein : HDL)のコレステロール取り込み能と糖尿病発症の関係:久山町研究.

    平川洋一郎、杜 隆嗣、東岡真由、吉成匡人、本田貴紀、吉田大悟、秦 淳、中村宇大、北園孝成、平田健一、二宮利治

    第51回日本動脈硬化学会総会・学術集会  2019.7 

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    Event date: 2020.7

    Language:Japanese  

    Venue:京都市   Country:Japan  

  • 日本の大規模コホートによる糖尿病と高血圧が心血管疾患による死亡の生涯リスクに与える影響:The EPOCH-JAPAN study.<ポスター>

    今井由希子、平田 匠、斎藤重幸、二宮利治、宮本恵宏、大西浩文、磯 博康、三浦克之、玉腰暁子、山田美智子、木山昌彦、石川鎮清、岡村智教

    第51回日本動脈硬化学会総会・学術集会  2019.7 

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    Event date: 2020.7

    Language:Japanese  

    Venue:京都市   Country:Japan  

  • 生活習慣病と認知症:久山町研究でわかってきたこと. Invited

    二宮利治

    健康まるごと福岡学園第45回田の歯科祭  2019.10 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 腎症を伴う糖尿病の臨床と疫学研究~薬物治療を含めて~.

    二宮利治

    福岡薬物治療研究会  2019.10 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • 高血圧と脳心血管イベントの疫学~久山町研究を中心に~. Invited International conference

    二宮利治

    武田高血圧領域 Topics Web講演会  2019.10 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:全国サテライト会場   Country:Japan  

  • データ連携最前線.

    二宮利治

    第1回日本オープンイノベーション大賞「内閣総理大臣賞」受賞記念 弘前大学COIヘルシーエイジング・イノベーションフォーラム2019  2019.10 

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    Event date: 2020.7

    Language:Japanese  

    Venue:東京   Country:Japan  

  • コホート研究からみた認知症予防.

    二宮利治

    第2回認知症と糖尿病・メタボ  2019.10 

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    Event date: 2020.7

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域住民における望ましくない食習慣の集積と肥満および腹部肥満の関連:久山町研究.

    石田有紀、吉田大悟、本田貴紀、平川洋一郎、柴田舞欧、坂田智子、秦 淳、二宮利治

    第26回日本未病システム学会学術総会  2019.10 

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    Event date: 2020.7

    Language:Japanese  

    Venue:名古屋市   Country:Japan  

  • 住民健診による高血圧管理の取組:久山町研究<スポンサードシンポジウム>若中年期高血圧管理の介入法を考える. Invited

    二宮利治

    第42回日本高血圧学会総会  2019.10 

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    Event date: 2020.7

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 日本人地域住民における高血圧発症予測モデルの開発:久山町研究.

    大石絵美、坂田智子、秦 淳、平川洋一郎、吉田大悟、北園孝成、二宮利治

    第42回日本高血圧学会総会  2019.10 

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    Event date: 2020.7

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 糖尿病と癌の関係:久山町研究の成績を中心に. Invited

    二宮利治

    第57回日本糖尿病学会九州地方会  2019.10 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:佐賀市   Country:Japan  

  • 地域住民における食物繊維の種類別摂取量が糖尿病発症に及ぼす影響:久山町研究.

    木村安美、吉田大悟、平川洋一郎、秦 淳、本田貴紀、柴田舞欧、内田和宏、二宮利治

    第78回日本公衆衛生学会総会  2019.10 

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    Event date: 2020.7

    Language:Japanese  

    Venue:高知市   Country:Japan  

  • 地域高齢者において情緒的孤独感は認知症発症リスク上昇に関連する:久山町研究.

    柴田舞欧、細井昌子、秦 淳、吉田大悟、二宮利治

    第78回日本公衆衛生学会総会  2019.10 

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    Event date: 2020.7

    Language:Japanese  

    Venue:高知市   Country:Japan  

  • <優秀口演賞>地域高齢者において情緒的孤独感は認知症発症リスク上昇に関連する:久山町研究.

    柴田舞欧、細井昌子、秦 淳、吉田大悟、二宮利治

    第78回日本公衆衛生学会総会  2019.10 

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    Event date: 2020.7

    Language:Japanese  

    Venue:高知市   Country:Japan  

  • 食事と認知症の関係:久山町研究<シンポジウム>栄養と認知機能-日本人を対象とした疫学研究-. Invited

    二宮利治

    第9回日本認知症予防学会学術集会、名古屋市、2019.10  2019.10 

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    Event date: 2020.7

    Language:Japanese  

    Venue:名古屋市   Country:Japan  

  • 地域住民における糖尿病の疫学研究「久山町研究」. Invited

    二宮利治

    日本臨床検査自動化学会第51回大会  2019.10 

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    Event date: 2020.7

    Language:Japanese  

    Venue:横浜市   Country:Japan  

  • 生活習慣と認知症:久山町研究の知見より. Invited

    二宮利治

    企業支援シンポジウム中小企業と認知症  2019.11 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • Perspectives on the burden of dementia and its prevention in Japan: the Hisayama Study. Invited

    二宮利治

    JICA2019年度青年研修、久留米市、2019.11  2019.11 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 高尿酸血症とCKD.

    二宮利治

    第263回生理学を志向する内科診療討論会  2019.11 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 久山町研究について.

    二宮利治

    令和元年度福岡県保健福祉環境事務所等勤務医師保健福祉行政研修  2019.11 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • Serum NT-proBNP Level is a Predictor for Developing Atrial Fibrillation in a General Japanese Population: the Hisayama Study.

    Nagata T, Hata J, Sakata S, Oishi E, Honda T, Furuta Y, Ohara T, Yoshida D, Hirakawa Y, Shibata M, Ide T, Kitazono T, Tsutsui H, Ninomiya T

    American Heart Association Scientific Sessions 2019  2019.11 

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    Event date: 2020.7

    Language:English  

    Venue:Philadelphia, PA   Country:United States  

  • Albuminuria is a biomarker for severity of white matter hyperintensities on brain MRI in a general elderly population of Japanese: the Hisayama Study. International conference

    Yamasaki K, Hata J, Hirabayashi N, Furuta Y, Ohara T, Hirakawa Y, Nakano T, Kitazono T, Ninomiya T

    ASN Kidney Week 2019,  2019.11 

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    Event date: 2020.7

    Language:English  

    Venue:Washinton, DC   Country:United States  

  • Urinary N-terminal pro-brain natriuretic peptide is a useful biomarker for cardiovascular events in a general Japanese population: the Hisayama Study. International conference

    Yamasaki K, Hata J, Hirakawa Y, Sakata S, Nakano T, Kitazono T, Ninomiya T

    ASN Kidney Week 2019  2019.11 

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    Event date: 2020.7

    Language:English  

    Venue:Washinton, DC   Country:United States  

  • 地域高齢者において情緒的孤独感は認知症発症リスク上昇に関連する:久山町研究.

    柴田舞欧、小原知之、細井昌子、秦 淳、吉田大悟、平林直樹、森崎悠紀子、安野広三、須藤信行、二宮利治

    第2回日本心身医学関連学会合同集会  2019.11 

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    Event date: 2020.7

    Language:Japanese  

    Venue:大阪市   Country:Japan  

  • 地域住民における潜在的MAC感染症者有病率の検討:久山町研究.

    吉田大悟、鷲尾康圭、秦 淳、本田貴紀、柴田舞欧、平川洋一郎、坂田智子、仁木満美子、星野仁彦、二宮利治

    第26回日本未病システム学会学術総会  2019.11 

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    Event date: 2020.7

    Language:Japanese  

    Venue:名古屋市   Country:Japan  

  • 認知症対策におけるコホート研究と予防について:久山町研究の知見より. Invited

    二宮利治

    第38回日本認知症学会学術集会  2019.11 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:東京都   Country:Japan  

  • 地域住民における糖尿病と認知症の疫学研究. <シンポジウム>糖代謝異常と認知症. Invited

    二宮利治

    第38回日本認知症学会学術集会  2019.11 

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    Event date: 2020.7

    Language:Japanese  

    Country:Japan  

  • 認知症の発症リスクと生活習慣改善の重要性.

    二宮利治

    老後を変える共創会議  2019.12 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 意外と知らない生活習慣と認知症の関係. Invited

    二宮利治

    2019中央区健康フェア  2019.10 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 糖尿病に関する最近の知見:久山町研究.

    二宮利治

    第7回日本糖尿病療養指導学術集会  2019.7 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • Epidemiological basis for preventive medicine for cardiovascular disease. International conference

    Ninomiya T

    日露予防医療診断センター設立会議  2019.7 

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    Event date: 2019.11

    Language:Japanese  

    Venue:Khabarovsk, Russia,   Country:Japan  

  • 食事と認知症の関係:久山町研究.

    二宮利治

    第38回日本歯科学教育学会総会および学術大会  2019.7 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • 腎症を伴う糖尿病の臨床と疫学研究~薬物治療を含めて~. Invited

    二宮利治

    諫早医師会学術講演会  2019.7 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:諫早市   Country:Japan  

  • 高尿酸血症とCKD:久山町研究の成績から考える.

    二宮利治

    日医生涯教育協力講座  2019.7 

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    Event date: 2019.11

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • Community-based dementia cohort study: the Hisayama Study. International conference

    Ninomiya T

    The 1st Joint Scientific Meeting on Physical Activity and Exercise Science, Fukuoka, Japan, 2019.8  2019.8 

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    Event date: 2019.11

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 地域住民における血清NTproBNP測定の意義:久山町研究.

    二宮利治

    心房細動の再発・重症化予防を考える  2019.8 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:仙台市   Country:Japan  

  • 将来の糖尿病発症を予測するICTツール「ひさやま元気予報」を活用した保健指導の効果:福岡県久山町の産官学連携の取り組み.

    吉田大悟、石田有紀、持松可奈子、山下友紀子、矢野由里恵、二宮利治

    第23回日本健康福祉政策学会学術大会 in ひさやま  2019.9 

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    Event date: 2019.11

    Language:Japanese  

    Venue:糟屋郡久山町   Country:Japan  

  • 久山町における官学共同の糖尿病対策の取り組み.

    持松可奈子、山下友紀子、矢野由里恵、木下愛梨、稲永みき、吉田大悟、石田有紀、清原 裕、二宮利治、國嵜和幸

    第23回日本健康福祉政策学会学術大会 in ひさやま  2019.9 

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    Event date: 2019.11

    Language:Japanese  

    Venue:糟屋郡久山町   Country:Japan  

  • Glucose tolerance status and beta and alpha cell mass in community-based autopsy samples of Japanese: the Hisayama Study. International conference

    Inaishi J, Saisho Y, Mukai N, Hirakawa Y, Yoshida D, Hata J, Watanabe Y, Oda Y, Itoh H, Ninomiya T

    55th Annual Meeting of the European Association for the Study of Diabetes,  2019.9 

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    Event date: 2019.11

    Language:English  

    Venue:Barcelona, Spain   Country:Japan  

  • 遺伝的スコアと脳梗塞発症:久山町研究.

    八谷剛志、秦 淳、平川洋一郎、吉田大悟、古田芳彦、北園孝成、清水厚志、二宮利治

    日本臨床疫学会第3回年次学術大会  2019.9 

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    Event date: 2019.11

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 地域高齢者において情緒的孤独感は認知症発症リスク上昇に関連する:久山町研究.

    柴田舞欧、小原知之、細井昌子、秦 淳、吉田大悟、平林直樹、森崎悠紀子、安野広三、須藤信行、二宮利治

    日本臨床疫学会第3回年次学術大会  2019.9 

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    Event date: 2019.11

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • ランチョンセミナー7.

    二宮利治

    日本臨床疫学会第3回年次学術大会、福岡市、2019.9  2019.9 

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    Event date: 2019.11

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 伝統的な疫学研究を継承して.

    二宮利治

    日本臨床疫学会第3回年次学術大会  2019.9 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 特別講演

    二宮利治

    日本臨床疫学会第3回年次学術大会  2019.9 

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    Event date: 2019.11

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 我が国における認知症の疫学研究:久山町研究を中心に. Invited

    二宮利治

    令和元年度愛媛大学医学部附属病院 認知症疾患医療センター講演会  2019.9 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東温市   Country:Japan  

  • 糖尿病・脂質代謝異常と心血管病リスク:久山町研究.

    二宮利治

    第6回糖尿病と心血管障害を考える会  2019.9 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • 地域住民における糖尿病予防の重要性:久山町研究.

    二宮利治

    Total Care Seminar in CHIBA、千葉市、2019.9  2019.9 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千葉市   Country:Japan  

  • 糖尿病合併症に関する最近の知見:久山町研究<シンポジウム>大規模臨床試験と実臨床が教えてくれたこと.

    二宮利治

    日本糖尿病学会第56回九州地方会  2018.10 

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    Event date: 2019.10 - 2019.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 糖尿病, 脳梗塞, 認知症のゲノム疫学研究<明日へのシンポジウム2>疫学部会.

    秦 淳、二宮利治

    第51回日本動脈硬化学会総会・学術集会  2019.7 

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    Event date: 2019.8

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • N-terminal pro-B-type natriuretic peptide and risk of dementia in a general Japanese elderly population: the Hisayama Study.

    Nagata T, Ohara T, Hata J, Sakata S, Furuta Y, Yoshida D, Honda T, Hirakawa Y, Ide T, Kanba S, Kitazono T, Tsutsui H, Ninomiya T

    第83回日本循環器学会学術集会  2019.3 

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    Event date: 2019.8

    Language:Japanese  

    Venue:横浜市   Country:Japan  

  • 食事パターンと認知症の関係:久山町研究<シンポジウム>食による脳機能改善を考える.

    二宮利治

    日本農芸化学会2019年度大会  2019.3 

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    Event date: 2019.8

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 糖尿病が脳疾患に及ぼす影響:久山町研究.

    二宮利治

    第26回筑豊糖尿病治療を考える会  2019.3 

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    Event date: 2019.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡県飯塚市   Country:Japan  

  • シンポジウム6.高齢者コホート研究の現在.

    二宮利治

    第38回日本社会精神医学会  2019.3 

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    Event date: 2019.8

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域住民における認知症コホート研究:久山町研究<シンポジウム>高齢者コホート研究の現在.

    二宮利治

    第38回日本社会精神医学会  2019.3 

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    Event date: 2019.8

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域住民における脳卒中と各病型の発症率の時代的推移:久山町研究<シンポジウム>我が国の脳卒中医療の未来像.

    二宮利治

    第44回日本脳卒中学会学術集会  2019.3 

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    Event date: 2019.8

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 脳梗塞ともやもや病感受性遺伝子 RNF213 p.4810K 変異の関連<シンポジウム>脳卒中の遺伝学、希少な脳血管障害.

    岡崎周平、森本貴昭、鎌谷洋一郎、上村鉄兵、高橋 淳、中川原譲二、古賀政利、豊田一則、鷲田和夫、齊藤 聡、望月秀樹、吾郷哲朗、秦 淳、二宮利治、猪原匡史

    第44回日本脳卒中学会学術集会  2019.3 

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    Event date: 2019.8

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 血糖関連指標(HbA1c, グリコアルブミン)と大脳白質病変の関連:久山町研究.

    古田芳彦、秦 淳、平林直樹、小原知之、吉田大悟、平川洋一郎、柴田舞欧、本田貴紀、坂田智子、脇坂義信、吾郷哲朗、北園孝成、二宮利治

    第44回日本脳卒中学会学術集会  2019.3 

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    Event date: 2019.8

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 生活習慣・生活習慣病と認知症・アルツハイマー病.

    二宮利治

    第30回日本医学会総会2019中部  2019.4 

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    Event date: 2019.8

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋市   Country:Japan  

  • 生活習慣病と認知症.

    二宮利治

    平成31年度東彼杵町食生活改善推進協議会研修会  2019.4 

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    Event date: 2019.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東彼杵郡東彼杵町   Country:Japan  

  • 高尿酸血症と脳心腎血管疾患の予後との関係.

    二宮利治

    第109回聖マリア病院地域医療支援講演会  2019.4 

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    Event date: 2019.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡県久留米市   Country:Japan  

  • 一般住民におけるインスリン分泌障害およびインスリン抵抗性と2型糖尿病発症の関係:久山町研究.<ポスター>

    吉成匡人、平川洋一郎、秦 淳、東岡真由、本田貴紀、吉田大悟、向井直子、中村宇大、北園孝成、二宮利治

    第62回日本糖尿病学会年次学術集会  2019.5 

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    Event date: 2019.8

    Language:Japanese  

    Venue:仙台市   Country:Japan  

  • 血清エイコサペンタエン酸/アラキドン酸比と血清レジスチンの関係:久山町研究.<ポスター>

    東岡真由、平川洋一郎、川村良一、吉成匡人、本田貴紀、吉田大悟、秦 淳、髙田康徳、大澤春彦、二宮利治

    第62回日本糖尿病学会年次学術集会  2019.5 

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    Event date: 2019.8

    Language:Japanese  

    Venue:仙台市   Country:Japan  

  • 久山町剖検例における糖代謝関連因子および遺伝的背景とα・β細胞量との関連.

    稲石 淳、税所芳史、向井直子、平川洋一郎、吉田大悟、秦 淳、渡辺雄祐、小田義直、伊藤 裕、二宮利治

    第62回日本糖尿病学会年次学術集会  2019.5 

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    Event date: 2019.8

    Language:Japanese  

    Venue:仙台   Country:Japan  

  • 高比重リポ蛋白(High-density lipoprotein : HDL)のコレステロール取り込み能と糖尿病発症の関係:久山町研究.

    平川洋一郎、杜 隆嗣、東岡真由、吉成匡人、本田貴紀、吉田大悟、秦 淳、中村宇大、北園孝成、平田健一、二宮利治

    第62回日本糖尿病学会年次学術集会  2019.5 

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    Event date: 2019.8

    Language:Japanese  

    Venue:仙台市   Country:Japan  

  • 地域コホート研究の実際:久山町研究.

    二宮 利治

    名城大学薬学部3年生講義  2019.5 

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    Event date: 2019.8

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:名古屋市   Country:Japan  

  • 糖尿病と睡眠、認知症の関係:久山町研究.

    二宮利治

    2019.5 

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    Event date: 2019.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:久留米市   Country:Japan  

  • 日本人地域住民における心房細動発症のリスク予測モデルの開発:久山町研究.

    秦 淳、坂田智子、永田拓也、平川洋一郎、大石絵美、本田貴紀、吉田大悟、北園孝成、二宮利治

    第55回日本循環器病予防学会学術集会  2019.5 

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    Event date: 2019.8

    Language:Japanese  

    Venue:久留米市   Country:Japan  

  • 福岡県久山町における認知症の疫学研究<合同シンポジウム1>コホート研究から得られた認知症に関する最近の知見.

    秦 淳、小原知之、二宮利治

    第55回日本循環器病予防学会学術集会  2019.5 

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    Event date: 2019.8

    Language:Japanese  

    Venue:久留米市   Country:Japan  

  • 中村公隆、吉田大悟、本田貴紀、秦 淳、柴田舞欧、平川洋一郎、古田芳彦、北園孝成、中島康晴、二宮利治

    地域高齢住民におけるサルコペニアの有病率と死亡リスク:久山町研究.

    第92回日本整形外科学会学術総会  2019.5 

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    Event date: 2019.8

    Language:Japanese  

    Venue:横浜市   Country:Japan  

  • 地域高齢住民におけるアルブミン尿と大脳白質病変容積の関連:久山町研究.

    山﨑景介、秦 淳、平林直樹、古田芳彦、髙江啓太、中野敏昭、北園孝成、二宮利治

    第62回日本腎臓学会学術総会  2019.6 

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    Event date: 2019.8

    Language:Japanese  

    Venue:名古屋市   Country:Japan  

  • 慢性腎臓病と心疾患リスク:久山町研究.

    二宮利治

    中外製薬(株)外部講師勉強会  2019.6 

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    Event date: 2019.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 高尿酸血症とCKD:久山町研究の成績から考える.

    二宮利治

    第62回日本腎臓学会学術総会  2019.6 

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    Event date: 2019.8

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:名古屋   Country:Japan  

  • 地域住民における慢性腎臓病と認知症の関係:久山町研究.

    二宮利治

    第62回日本腎臓学会学術総会  2019.6 

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    Event date: 2019.8

    Language:Japanese  

    Venue:名古屋市   Country:Japan  

  • 九州大学におけるコホート研究の実践.

    二宮利治

    第5回九州大学日本橋サテライトセミナー  2019.6 

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    Event date: 2019.8

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:東京   Country:Japan  

  • 地域高齢住民におけるサルコペニアの有病率と関連因子:久山町研究.

    中村公隆、吉田大悟、本田貴紀、秦 淳、柴田舞欧、平川洋一郎、古田芳彦、北園孝成、中島康晴、二宮利治

    第137回西日本整形・災害外科学会学術集会  2019.6 

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    Event date: 2019.8

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 地域住民における認知症コホート研究~筋力低下予防の重要性:久山町研究.

    二宮利治

    第137回西日本整形・災害外科学会学術集会  2019.6 

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    Event date: 2019.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • 地域住民における毛髪中水銀濃度とメタボリックシンドローム発症との関連:久山町研究.

    小西秀和、吉田大悟、秦 淳、田中昭代、平田美由紀、平川洋一郎、柴田舞欧、本田貴紀、坂田智子、二宮利治

    第29回日本疫学会学術総会  2019.2 

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    Event date: 2019.3

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域高齢住民における認知症の有病率・発症率・予後の時代的変化:久山町研究.

    小原知之、二宮利治

    第22回九州老年期認知症研究会  2018.6 

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    Event date: 2019.3

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 糖尿病と癌の関連 疫学的観点から.

    二宮利治

    生活習慣病と癌セミナー  2018.8 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • Epidemiology of clinically-diagnosed dementia in a Japanese community: the Hisayama Study<Symposium>Longitudinal and cohort clinicopathological study of aging and dementia. International conference

    Ohara T, Ninomiya T

    The 19th International Congress of Neuropathology  2018.9 

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    Event date: 2019.3

    Language:English  

    Venue:tokyo   Country:Japan  

  • Serum soluble TREM2 and risk of dementia: the Hisayama Study.

    Ohara T, Kanba S, Tanaka M, Yamakage H, Iwaki T, Inoue T, Sato-Asahara N, Ninomiya T

    第40回日本生物学的精神医学会  2018.9 

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    Event date: 2019.3

    Language:Japanese  

    Venue:神戸市   Country:Japan  

  • 幼少期の被養育体験は成人後の糖尿病に関連する:久山町研究.

    柴田舞欧、細井昌子、安野広三、平林直樹、平川洋一郎、河田 浩、岩城理恵、澤本良子、須藤信行、二宮利治

    日本臨床疫学会第2回年次学術大会  2018.9 

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    Event date: 2019.3

    Language:Japanese  

    Venue:京都   Country:Japan  

  • 日本人地域一般住民における small dence LDLコレステロールと虚血性心疾患発症の関連:久山町研究.

    東岡真由、坂田智子、吉田大悟、平川洋一郎、秦 淳、大澤春彦、二宮利治

    日本臨床疫学会第2回年次学術大会  2018.9 

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    Event date: 2019.3

    Language:Japanese  

    Venue:京都   Country:Japan  

  • 臨床研究、プレッシャーバトル!!.

    二宮利治

    日本臨床疫学会第2回年次学術大会  2018.9 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • Meet the Expert1.

    二宮利治

    日本臨床疫学会第2回年次学術大会  2018.9 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • 地域住民における認知症コホート研究:久山町研究<シンポジウム>画像からみる認知症予防.

    二宮利治

    第8回日本認知症予防学会学術集会  2018.9 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 血清尿酸値と慢性腎臓病発症の関係(久山町研究より)<パネルディスカッション>高尿酸血症・痛風の最近の話題.

    二宮利治

    日医生涯教育協力講座  2018.9 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:宮崎市   Country:Japan  

  • 疾病予防における血清EPA/AA比の重要性~久山町研究の成績より~. Invited

    二宮利治

    第66回日本心臓病学会学術集会  2018.9 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:大阪市   Country:Japan  

  • 健康長寿に必要な生活習慣病対策:久山町研究<スポンサードシンポジウム>健康・長寿を目指す体質と生活を考える.

    二宮利治

    第68回日本体質医学会総会  2018.9 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜市   Country:Japan  

  • 28日間にわたる家庭血圧の測定状況と血圧値:福岡高血圧コホート(FHC)研究.

    大森 将、松村 潔、大坪俊夫、冨永光裕、鍵山俊太郎、川崎純也、赤崎 卓、藤嶋八重、阿部 功、二宮利治、北園孝成、土橋卓也

    第41回日本高血圧学会総会  2018.9 

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    Event date: 2019.3

    Language:Japanese  

    Venue:旭川市   Country:Japan  

  • 地域住民における白衣高血圧、仮面高血圧とアルブミン尿症の関連:久山町研究.

    秦 淳、福原正代、坂田智子、有馬久富、平川洋一郎、米本孝二、向井直子、北園孝成、清原 裕、二宮利治

    第41回日本高血圧学会総会  2018.9 

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    Event date: 2019.3

    Language:Japanese  

    Venue:旭川市   Country:Japan  

  • 高血圧者の認知症発症リスクと降圧治療の有効性<シンポジウム>フレイルと高血圧.

    二宮利治

    第41回日本高血圧学会総会  2018.9 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:旭川市   Country:Japan  

  • 牛乳・乳製品および乳タンパク質摂取量と高血圧発症との関係:久山町研究. Invited

    大石絵美、坂田智子、吉田大悟、秦 淳、大坪俊夫、北園孝成、清原 裕、二宮利治

    第41回日本高血圧学会総会  2018.9 

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    Event date: 2019.3

    Language:Japanese  

    Country:Japan  

  • 心血管病の発症や認知機能の低下と家庭血圧測定に関する前向きコホート研究における登録時データの概要:福岡高血圧コホート(FHC)研究.

    松村 潔、大森 将、大坪俊夫、冨永光裕、鍵山俊太郎、川崎純也、赤崎 卓、藤嶋八重、阿部 功、二宮利治、北園孝成、土橋卓也

    第41回日本高血圧学会総会  2018.9 

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    Event date: 2019.3

    Language:Japanese  

    Venue:旭川市   Country:Japan  

  • 地域高齢住民における臥位高血圧と認知症発症の関連:久山町研究<シンポジウム>高血圧は認知症の成因になりうるのか?.

    坂田智子、大石絵美、小原知之、秦 淳、大坪俊夫、北園孝成、二宮利治

    第41回日本高血圧学会総会  2018.9 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:旭川市   Country:Japan  

  • 家庭血圧の日間変動と認知症との関連:久山町研究<シンポジウム>血圧変動評価と臓器障害.

    大石絵美、小原知之、坂田智子、福原正代、秦 淳、吉田大悟、柴田舞欧、大坪俊夫、北園孝成、清原 裕、二宮利治

    第41回日本高血圧学会総会  2018.9 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:旭川市   Country:Japan  

  • 家庭血圧の日間変動と認知症との関連:久山町研究.

    大石絵美、小原知之、坂田智子、福原正代、秦 淳、吉田大悟、柴田舞欧、大坪俊夫、北園孝成、清原 裕、二宮利治

    第41回日本高血圧学会総会  2018.9 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:旭川市   Country:Japan  

  • 地域高齢者における中年期から老年期の握力低下と認知症発症の関連:久山町研究

    畑部暢三、柴田舞欧、小原知之、大石絵美、吉田大悟、本田貴紀、秦 淳、神庭重信、北園孝成、二宮利治

    第40回日本生物学的精神医学会・第61回日本神経化学大会合同年会  2018.9 

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    Event date: 2019.3

    Language:Japanese  

    Venue:神戸市   Country:Japan  

  • 認知症の危険因子・防御因子:久山町研究<シンポジウム>認知症の危険因子・防御因子を考える.

    小原知之、二宮利治

    第37回日本認知症学会  2018.10 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:札幌市   Country:Japan  

  • 糖代謝異常と認知症:久山町研究.

    小原知之、二宮利治

    第39回日本肥満学会  2018.10 

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    Event date: 2019.3

    Language:Japanese  

    Venue:神戸市   Country:Japan  

  • 久山町研究と「ひさやま元気予報」について.

    二宮利治

    平成30年度ふくおか健康づくり県民会議総会~日本健康会議 in 福岡~  2019.1 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 地域一般住民における食物繊維摂取量と糖尿病発症との関連:久山町研究.

    木村安美、吉田大悟、平川洋一郎、秦 淳、本田貴紀、柴田舞欧、坂田智子、内田和宏、二宮利治

    第29回日本疫学会学術総会、東京、2019.1  2019.1 

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    Event date: 2019.3

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域高齢住民における血清エライジン酸濃度と認知症発症の関連:久山町研究.

    本田貴紀、小原知之、篠原正和、秦 淳、杜 隆嗣、吉田大悟、石田達郎、平川洋一郎、入野康宏、柴田舞欧、坂田智子、神庭重信、平田健一、二宮利治

    第29回日本疫学会学術総会  2019.1 

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    Event date: 2019.3

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 高尿酸血症とCKD:久山町研究の成績を中心に.

    二宮利治

    CKD重症化予防を考える、福岡市、2019.2  2019.2 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • 心血管病予防における脂質管理の重要性:久山町研究の成績を中心に.

    二宮利治

    日本慢性疾患重症化予防学会第5回年次学術集会  2019.2 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:西宮市   Country:Japan  

  • 健康寿命延伸のための認知症予防:久山町研究.

    二宮利治

    日本医薬品卸勤務薬剤師会福岡県支部平成30年度継続研修会  2019.2 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 高尿酸血症フォーラム in 小倉、北九州市、2019.2

    二宮利治

    多職種連携研修会  2019.2 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 高尿酸血症とCKD:久山町研究の成績を中心に.

    二宮利治

    高尿酸血症フォーラム in 小倉  2019.2 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:北九州市   Country:Japan  

  • 糖尿病と認知症:久山町研究.

    二宮利治

    第20回福岡糖尿病療養指導士認定会総会および認定授与式、福岡市、2019.2  2019.2 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 慢性腎臓病と心疾患リスク:久山町研究.

    二宮利治

    第3回心・腎・糖尿病連携セミナー in 浜松、浜松市、2019.2  2019.2 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:浜松市   Country:Japan  

  • 生活習慣病と認知症:久山町研究. Invited

    二宮利治

    第7回認知症国会勉強会、東京、2019.2  2019.2 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 長寿に必要な生活習慣病対策:久山町研究.

    二宮利治

    第7回STI政策シンポジウム、福岡市、2019.2  2019.2 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡市   Country:Japan  

  • 脂質代謝異常と心血管病-久山町研究-.

    二宮利治

    第19回動脈硬化教育フォーラム  2019.2 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 心血管病予防における脂質管理の重要性:久山町研究の成績を中心に.

    二宮利治

    第19回動脈硬化教育フォーラム  2019.2 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 血清エチルアミン濃度と糖尿病発症の関係:久山町研究.

    二宮利治、平川洋一郎、吉成匡人、東岡真由、本田貴紀、柴田舞欧、坂田智子、吉田大悟、秦 淳、北園孝成

    第29回日本疫学会学術総会  2019.2 

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    Event date: 2019.3

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 生活習慣の予防(APP)に意義.

    二宮利治

    平成30年度保健衛生大会  2018.12 

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    Event date: 2019.2

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • 我が国における認知症の疫学研究:久山町研究<シンポジウムⅠ>認知症関連の最新トピック.

    二宮利治

    第20回感情・行動・認知(ABC)研究会  2018.10 

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    Event date: 2019.2

    Language:Japanese  

    Venue:大阪   Country:Japan  

  • 認知症とフレイル~久山町研究の成績を中心に.

    二宮利治

    第154回北九州透析懇話会  2018.10 

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    Event date: 2019.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北九州市   Country:Japan  

  • 心血管病リスク予測モデルの開発と臨床的有用性評価-久山町研究-.<ポスター>

    本田貴紀、吉田大悟、秦 淳、平川洋一郎、石田有紀、柴田舞欧、坂田智子、北園孝成、二宮利治

    第25回日本未病システム学会学術総会  2018.10 

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    Event date: 2019.2

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域一般住民における気流制限の有病率の時代的変化:久山町研究.

    緒方大聡、平川洋一郎、松元幸一郎、秦 淳、吉田大悟、福山 聡、井上博雅、北園孝成、二宮利治、中西洋一

    第25回日本未病システム学会学術総会  2018.10 

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    Event date: 2019.2

    Language:Japanese  

    Venue:東京   Country:Japan  

  • βアラニン血中濃度と認知症発症の関連:久山町研究.

    秦 淳、小原知之、片倉喜範、清水邦義、山下俊太郎、吉田大悟、本田貴紀、平川洋一郎、柴田舞欧、坂田智子、北園孝成、久原 哲、二宮利治

    第25回日本未病システム学会学術総会  2018.10 

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    Event date: 2019.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 血糖指標とアルツハイマー型認知症:久山町研究の成績より.

    二宮利治

    第25回日本未病システム学会学術総会  2018.10 

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    Event date: 2019.2

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:東京   Country:Japan  

  • Serum NT-proBNP level is A useful biomarker for future dementia in a general Japanese elderly population: the Hisayama Study.<poster> International conference

    Nagata T, Ohara T, Honda T, Sakata S, Hata J, Hirakawa Y, Yoshida D, Shibata M, Ide T, Tsutsui H, Ninomiya T

    AHA Scientific Sessions 2018, Chicago, Illinois, 2018.11  2018.11 

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    Event date: 2019.2

    Language:English  

    Venue:Chicago, Illinois,   Country:United States  

  • 脳・心血管イベント予防対策における血圧管理の重要性~久山町研究を中心に~.

    二宮利治

    武田高血圧領域Topic Web講演会、全国サテライト会場  2018.11 

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    Event date: 2019.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 継往開来:久山町研究を継承して. Invited

    二宮利治

    平成30年度開講56周年記念会九州大学医学部心療内科教室  2018.11 

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    Event date: 2019.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 久山町研究-58年目を迎えて-.

    二宮利治

    第6回「医学歴史のうねり」セミナー  2018.11 

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    Event date: 2019.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 生活習慣病と認知症.

    二宮利治

    認知症ファーラム in いよし  2018.12 

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    Event date: 2019.2

    Language:Japanese  

    Venue:伊予市   Country:Japan  

  • 心房細動の危険因子~久山町研究の成績から~.

    二宮利治

    心房細動の再発・重症化予防を考える  2018.12 

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    Event date: 2019.2

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:仙台市   Country:Japan  

  • 発酵食品と健康長寿. Invited

    二宮利治

    HISAYAMA DINING & WORKSHOP  2018.9 

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    Event date: 2018.9 - 2019.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡市   Country:Japan  

  • 心血管病リスク予測モデルの開発-久山町研究-

    本田貴紀、吉田大悟、石田有紀、平川洋一郎、秦 淳、岸本裕歩、二宮利治

    第50回日本動脈硬化学会総会学術集会  2018.7 

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    Event date: 2018.9

    Language:Japanese  

    Venue:大阪市   Country:Japan  

  • 糖尿病と認知症:久山町研究.

    二宮利治

    糖尿病の認知機能障害を考える  2018.6 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:西宮市   Country:Japan  

  • 循環器疾患疫学総論.1.久山町研究の方法と知見. Invited

    二宮利治

    リーディング大学院前期講義  2018.6 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:大津市   Country:Japan  

  • 脂質異常症と心血管病の疫学研究:久山町研究.

    二宮利治

    第47回京浜リピッドクラブ  2018.6 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京   Country:Japan  

  • 地域一般住民における血清高感度CRPレベルと心房細動発症との関連:久山町研究.

    吉川智子、秦 淳、平川洋一郎、坂田智子、永田拓也、廣岡良隆、筒井裕之、北園孝成、二宮利治

    第54回日本循環器病予防学会学術集会  2018.6 

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    Event date: 2018.9

    Language:Japanese  

    Venue:神戸市   Country:Japan  

  • 生活習慣病や生活習慣との関連:久山町研究<シンポジウム>認知症の新規発症を減らすためにできることは何か?

    小原知之、神庭重信、二宮利治

    第114回日本精神神経学会学術総会  2018.6 

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    Event date: 2018.9

    Language:Japanese  

    Venue:神戸市   Country:Japan  

  • 連続剖検例にて神経原線維変化型認知症と診断された認知症例の臨床的特徴:久山町研究.

    畑部暢三、小原知之、本田裕之、岩城 徹、神庭重信、二宮利治

    第114回日本精神神経学会学術総会  2018.6 

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    Event date: 2018.9

    Language:Japanese  

    Venue:神戸市   Country:Japan  

  • 高尿酸血症と慢性腎臓病の関係:久山町研究の成績より.

    二宮利治

    日医生涯教育協力講座  2018.7 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:長崎市   Country:Japan  

  • 地域住民における代謝性疾患の時代的推移:久山町研究.

    二宮利治

    日本スポーツ栄養学会第5回大会  2018.7 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都市   Country:Japan  

  • 地域住民における心血管病の危険因子:久山町研究の最新の知見より<シンポジウム>明日へのシンポジウム1.

    二宮利治

    第50回日本動脈硬化学会総会学術集会  2018.7 

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    Event date: 2018.9

    Language:Japanese  

    Venue:大阪市   Country:Japan  

  • 地域一般住民における気流制限の有病率の時代的変化:久山町研究.

    緒方大聡、平川洋一郎、松元幸一郎、秦 淳、吉田大悟、福山 聡、井上博雅、北園孝成、二宮利治、中西洋一

    第92回閉塞性肺疾患研究会  2018.7 

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    Event date: 2018.9

    Language:Japanese  

    Venue:東京   Country:Japan  

  • The association between progression of dementia and loneliness in an older general population from the viewpoint of sociak and emotional aspects: the Hisayama Study.<poster> International conference

    Shibata M, Hosoi M, Ohara T, Hirabayashi N, Anno K, Yoshida D, Kanba S, Sudo N, Ninomiya T

    ACPM2018  2018.8 

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    Event date: 2018.8 - 2018.9

    Language:English  

    Venue:Seoul   Country:Korea, Republic of  

  • 一般住民における幼少期の被養育体験と成人後の糖尿病の関連:久山町研究.

    柴田舞欧、細井昌子、安野広三、平林直樹、平川洋一郎、河田 浩、岩城理恵、澤本良子、久保千春、二宮利治、須藤信行

    第59回日本心身医学会総会ならびに学術講演会  2018.6 

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    Event date: 2018.7

    Language:Japanese  

    Venue:名古屋市   Country:Japan  

  • The Association of Small-dense Low-density Lipoprotein (LDL) Cholesterol and Triglycerides on LDL with Carotid Atherosclerosis: The Hisayama Study.

    Yoshinari M, Hirakawa Y, Sakata S, Hata J, Ninomiya T, Kitazono T

    第82回日本循環器学会学術集会  2018.3 

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    Event date: 2018.7

    Language:Japanese  

    Venue:大阪   Country:Japan  

  • Small Dense Low-Density Lipoprotein Cholesterol and the Development of Coronary Heart Disease in a Japanese Community: The Hisayama Study.

    東岡真由、坂田智子、平川洋一郎、秦 淳、大澤春彦、二宮利治

    第82回日本循環器学会学術集会  2018.3 

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    Event date: 2018.7

    Language:Japanese  

    Venue:大阪   Country:Japan  

  • 食事と認知症の関係:久山町研究. Invited

    二宮利治

    第15回日本口腔ケア学会総会・学術大会  2018.4 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • Changes in the prevalence of airflow limitetion in community-dwelling Japanese subjects: the Hisayama Study.<English Poster Discussion>

    Ogata H, Hirakawa Y, Matsumoto K, Fukuyama S, Inoue H, Kitazono T, Ninomiya T, Nakanishi Y

    第58回日本呼吸器学会学術講演会  2018.4 

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    Event date: 2018.7

    Language:Japanese  

    Venue:大阪市   Country:Japan  

  • 糖尿病性腎臓病の臨床・疫学研究. Invited

    二宮利治

    飯塚医師会学術講演会  2018.5 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:飯塚市   Country:Japan  

  • 地域住民における認知症の実態とその予防-久山町研究-. Invited

    二宮利治

    第17回新居浜認知症ネットワーク  2018.5 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:新居浜市   Country:Japan  

  • 高尿酸血症とCKD・CVDとの関連<パネルディスカッション>様々の疾患リスクとしての高尿酸血症. Invited

    二宮利治

    日医生涯教育協力講座  2018.5 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  • 地域住民を対象とした認知症コホート研究. Invited

    二宮利治

    京都大学リサーチセミナー  2018.5 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Changes in the Prevalence of Airflow Limitation in Community-Dwelling Japanese Subjects: The Hisayama Study.<poster> International conference

    Ogata H, Hirakawa Y, Matsumoto K, Fukuyama S, Inoue H, Kitazono T, Ninomiya T, Nakanishi Y

    ATS 2018,  2018.5 

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    Event date: 2018.7

    Language:Japanese  

    Venue:San Diego ,CA   Country:Japan  

  • 血圧日間変動と認知症発症との関連:久山町研究<シンポジウム>血圧調節機構と病態-良質な血圧管理を目指して.

    二宮利治

    第61回日本糖尿病学会年次学術集会  2018.5 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 久山町剖検例における糖代謝関連因子とα・β細胞量との関連.

    稲石 淳、税所芳史、向井直子、平川洋一郎、吉田大悟、秦 淳、渡辺雄祐、小田義直、伊藤 裕、二宮利治

    第61回日本糖尿病学会年次学術集会  2018.5 

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    Event date: 2018.7

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域住民における糖尿病有病率の時代的変化, 1988-2012年:久山町研究.

    向井直子、秦 淳、平川洋一郎、小原知之、吉田大悟、中村宇大、北園孝成、二宮利治

    第61回日本糖尿病学会年次学術集会  2018.5 

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    Event date: 2018.7

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域住民における糖尿病と脳疾患の関係:久山町研究<レクチャー>糖尿病診療に必要な知識.

    二宮利治

    第52回糖尿病学の進歩  2018.3 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 老年期の脂肪量および除脂肪体重が認知症発症に及ぼす影響:久山町研究.

    小原知之、神庭重信、二宮利治

    第39回日本生物学的精神医学会  2017.9 

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    Event date: 2018.4

    Language:Japanese  

    Venue:札幌市   Country:Japan  

  • Epidemiology of dementia in a Japanese community: the Hisayama Study.

    Ohara T, Ninomiya T

    第36回日本認知症学会学術集会  2017.11 

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    Event date: 2018.4

    Language:Japanese  

    Venue:金沢市   Country:Japan  

  • 地域高齢者における中年期から老年期の握力低下と認知症発症の関連:久山町研究.<ポスター>

    畑部暢三、柴田舞欧、小原知之、大石絵美、岸本裕歩、本田貴紀、吉田大悟、秦 淳、神庭重信、二宮利治

    第36回日本認知症学会学術集会  2017.11 

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    Event date: 2018.4

    Language:Japanese  

    Venue:金沢市   Country:Japan  

  • 地域住民における認知症の疫学研究. Invited

    二宮利治

    慶應義塾大学講義  2018.1 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Japan  

  • 久山町研究からみた認知症予防. Invited

    二宮利治

    原土井病院講演会  2018.1 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 血清尿酸値と慢性腎臓病発症の関係「久山町研究」より. Invited

    二宮利治

    高尿酸血症・痛風 Late Breaking Clinical Trials in 2018  2018.1 

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    Event date: 2018.4

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 認知症予防における糖尿病治療の重要性:久山町研究の成績より. Invited

    二宮利治

    小倉内科医会実地医家シリーズ講演会  2018.1 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:北九州市   Country:Japan  

  • 食事と脳卒中および認知症の関係:久山町研究. Invited

    二宮利治

    第6回食糧生産技術研究会  2018.2 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 『これからの日本人の高血圧治療について』~久山町研究から見る現状と課題~.

    二宮利治

    Hypertension FORUM in CHIBA  2018.2 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:浦安市   Country:Japan  

  • 認知症の疫学研究:久山町研究.

    二宮利治

    九州大学日本橋サテライト開所記念式典  2018.2 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 疾患予防における歩行機能と身体活動能の維持の重要性の検討.

    二宮利治

    弘前大学COIヘルシーエイジング・イノベーションサミット2018  2018.2 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:弘前市   Country:Japan  

  • 慢性腎臓病と心疾患の関係:久山町研究. Invited

    二宮利治

    大分大学医学部「大学院セミナー」  2018.2 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Japan  

  • 動脈硬化性疾患の危険因子:久山町研究.

    二宮利治

    第18回動脈硬化教育フォーラム  2018.2 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋市   Country:Japan  

  • Return of the Results of Epidemiological Research in Society: The Hisayama Study.

    二宮利治

    第82回日本循環器学会学術集会  2018.3 

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    Event date: 2018.4

    Language:Japanese  

    Venue:大阪市   Country:Japan  

  • 糖尿病性腎症の臨床・疫学研究.

    二宮利治

    DKD(Diabetic Kidney Disease)セミナー  2018.3 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Japan  

  • 循環器疾患の実態~久山町研究の成績から~.

    二宮利治

    心房細動診療の最前線  2018.3 

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    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  • 地域高齢住民における大脳白質病変の危険因子の検討:久山町研究.

    古田芳彦、秦 淳、平林直樹、由比智裕、向井直子、平川洋一郎、吾郷哲朗、北園孝成、二宮利治

    第43回日本脳卒中学会学術集会  2018.3 

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    Event date: 2018.4

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 地域高齢住民における未破裂脳動脈瘤の有病率とその危険因子:久山町研究.

    由比智裕、秦 淳、古田芳彦、向井直子、平川洋一郎、吾郷哲朗、北園孝成、二宮利治

    第43回日本脳卒中学会学術集会  2018.3 

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    Event date: 2018.4

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 糖尿病と認知症:久山町研究.

    二宮利治

    第4回分子遺伝糖尿病研究会  2018.3 

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    Event date: 2018.4

    Language:Japanese  

    Country:Japan  

  • 退形成性髄膜腫に広範な静脈性脳梗塞を合併した一剖検例.

    山﨑景介、秦 淳、髙江啓太、鈴木 諭、有村公一、吉本幸司、山下和海、飯原弘二、岩城 徹、二宮利治

    第28回日本老年医学会九州地方会  2018.3 

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    Event date: 2018.4

    Language:Japanese  

    Venue:沖縄県中頭郡   Country:Japan  

  • 糖尿病と認知症の関連 疫学的観点から:久山町研究<認知症シンポジウム>糖尿病と認知症~その関連性と発症予防、重症化予防を目指して~.

    向井直子、二宮利治

    第52回糖尿病学の進歩  2018.3 

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    Event date: 2018.3 - 2018.4

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 糖尿病疾患発症予測ソフトを活用した保健指導の効果:福岡県久山町の取り組み.

    吉田大悟、石田有紀、稲永みき、持松可奈子、上安由里恵、物袋由美子、二宮利治

    第6回日本公衆衛生看護学会学術集会  2018.1 

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    Event date: 2018.2

    Language:Japanese  

    Country:Japan  

  • 脳卒中・認知症の疫学研究:久山町研究. Invited

    二宮利治

    シスメックス株式会社講演会  2017.12 

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    Event date: 2018.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神戸市   Country:Japan  

  • 慢性腎臓病と心疾患リスク:久山町研究. Invited

    二宮利治

    中外製薬株式会社CKD座談会  2017.12 

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    Event date: 2018.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪市   Country:Japan  

  • 地域コホート研究の実際:久山町研究. Invited

    二宮利治

    和歌山県立医科大学大学院特別講義兼大学院教員FD研修会  2017.12 

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    Event date: 2018.2

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:伊都郡かつらぎ町   Country:Japan  

  • 地域住民における望ましくない食行動の集積と肥満の関連:久山町研究.

    石田有紀、吉田大悟、實藤愛梨、稲永みき、持松可奈子、上安由里恵、物袋由美子、二宮利治

    第6回日本公衆衛生看護学会学術集会  2018.1 

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    Event date: 2018.2

    Language:Japanese  

    Venue:大阪   Country:Japan  

  • ビッグデータ時代における臨床・疫学研究. Invited

    二宮利治

    熊本県医師会医学講座  2017.11 

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    Event date: 2017.12

    Language:Japanese  

    Venue:荒尾   Country:Japan  

  • 地域高齢者における認知症と孤独感の関連:久山町研究.

    柴田舞欧、小原知之、細井昌子、吉田大悟、平林直樹、安野広三、須藤信行、神庭重信、二宮利治

    日本臨床疫学会第1回年次学術大会  2017.9 

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    Event date: 2017.12

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 炎症と動脈硬化性疾患に関する地域疫学研究:久山町研究.

    二宮利治

    動脈硬化 Update 2017  2017.9 

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    Event date: 2017.12

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 久山町研究からみたわが国の認知症の現状と課題~慢性腎臓病(CKD)患者における知見も交えて~.

    二宮利治

    第5回福岡県CKD看護研究会  2017.9 

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    Event date: 2017.12

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 疾病予防における血清EPA/AA比の重要性:久山町研究の成績より.

    二宮利治

    第42回日本医用マススペクトル学会年会  2017.9 

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    Event date: 2017.12

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 総合研究(pooled analysis)の実際.

    二宮利治

    日本臨床疫学会第1回年次学術大会  2017.10 

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    Event date: 2017.12

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 将来の糖尿病発症リスクを予測するソフトウェアを活用した保健指導の効果:久山町研究.

    吉田大悟、石田有紀、本田貴紀、向井直子、二宮利治

    日本臨床疫学会第1回年次学術大会  2017.10 

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    Event date: 2017.12

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 健康寿命を延ばそう!~生活習慣病, 認知症, ロコモの予防の重要性~.

    二宮利治

    東区健康づくり講演会  2017.10 

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    Event date: 2017.12

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 久山町研究からみた健康寿命延伸に必要な取組.

    二宮利治

    第5回公衆衛生委員会  2017.10 

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    Event date: 2017.12

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 慢性腎臓病予防対策における尿酸管理の臨床的意義.

    二宮利治

    福岡市博多区・中央区内科医会合同学術講演会  2017.10 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡   Country:Japan  

  • これからの認知症対策について~認知症のリスクを高める生活習慣病~.

    二宮利治

    平成29年度認知症セミナー  2017.10 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:島根   Country:Japan  

  • 地域住民における脳疾患の危険因子-久山町研究-.

    二宮利治

    第40回日本高血圧学会総会  2017.10 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:松山   Country:Japan  

  • 血圧日間変動と認知症発症との関連:久山町研究.

    二宮利治

    第40回日本高血圧学会総会  2017.10 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • Japanese perspectives on dietary patterns and dementia. Invited International conference

    Ninomiya T

    IDF World Dairy Summit,  2017.10 

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    Event date: 2017.12

    Language:English  

    Venue:Belfast   Country:Japan  

  • <シンポジウム>糖尿病と糖質・炭水化物の科学.

    二宮利治

    第2回糖尿病・生活習慣病ヒューマンデータ研究会  2017.11 

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    Event date: 2017.12

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域在住非糖尿病者における座位時間とインスリン抵抗性の関連:久山町研究.<ポスター>

    本田貴紀、岸本裕歩、向井直子、秦 淳、吉田大悟、平川洋一郎、柴田舞欧、小原知之、熊谷秋三、二宮利治

    第24回日本未病システム学会学術総会  2017.11 

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    Event date: 2017.12

    Language:Japanese  

    Venue:横浜市   Country:Japan  

  • 認知症の疫学研究:久山町研究. Invited

    二宮利治

    高橋内科クリニック講演会  2017.11 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:直方   Country:Japan  

  • 地域高齢者における中年期から老年期までの握力変化と認知症発症の関連:久山町研究.<ポスター>

    畑部暢三、柴田舞欧、小原知之、大石絵美、岸本裕歩、本田貴紀、吉田大悟、秦 淳、神庭重信、二宮利治

    第24回日本未病システム学会学術総会  2017.11 

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    Event date: 2017.12

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • <プレナリーレクチャー3>Population studies of dementia over time, what can they tell us about the future of dementia? Invited

    二宮利治

    第36回日本認知症学会学術集会  2017.11 

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    Event date: 2017.12

    Language:Japanese  

    Venue:金沢   Country:Japan  

  • 久山町研究からみたと糖尿病と認知症の現状~男女差にも焦点をあてて~.

    二宮利治

    Okinawa Health Promotion Academic Meeting  2017.8 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  • 認知症と生活習慣病~認知症のリスクを高める生活習慣~.

    二宮利治

    平成29年度認知症セミナー  2017.6 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:伊予市   Country:Japan  

  • 地域住民の未破裂脳動脈瘤:久山町研究.

    二宮利治

    第26回日本脳ドック学会総会  2017.6 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • 認知症の疫学研究:久山町研究.

    二宮利治

    九大別府病院・春の集談会  2017.6 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:別府   Country:Japan  

  • 慢性腎臓病予防対策における尿酸治療の有用性<シンポジウム>循環器病予防から見た臨床研究と疫学研究の接点.

    二宮利治

    第53回日本循環器病予防学会学術集会  2017.6 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都市   Country:Japan  

  • 地域住民におけるNT-proBNPの変化率と総死亡および死因別死亡との関連:久山町研究.

    梅原 薫、平川洋一郎、秦 淳、向井直子、小原知之、吉田大悟、岸本裕歩、北園孝成、外須美夫、清原 裕、二宮利治

    第53回日本循環器病予防学会学術集会  2017.6 

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    Event date: 2017.9

    Language:Japanese  

    Venue:京都市   Country:Japan  

  • わが国における糖尿病と関連疾患の疫学調査:久山町研究の成績より.

    二宮利治

    Tokyo Diabetes Cutting Edge Seminar  2017.6 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京   Country:Japan  

  • 認知症とフレイル:久山町研究.

    二宮利治

    池田バスキュラーアクセス・透析・内科 講演会  2017.6 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • “Hypertension Paradox”の解決策を検討する<パネルディスカッション>.

    二宮利治、勝谷友宏、宮川政昭

    Takeda Hypertension Conference 2017 Summer  2017.7 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:東京   Country:Japan  

  • 久山町研究から考える脳・心血管イベント予防対策.

    二宮利治

    Takeda Hypertension Conference 2017 Summer  2017.7 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 糖尿病性腎症の臨床・疫学研究.

    二宮利治

    第9回「実地医家のための糖尿病セミナー」  2017.7 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 予防・国民への啓発.久山町研究から考える脳・心血管イベント予防対策。

    二宮利治

    全国高血圧領域 TOPICS Web講演会  2017.7 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • Risk factors for carotid atherosclerosis : the Hisayama Study.

    Hata J, Ninomiya T

    第49回日本動脈硬化学会総会・学術集会  2017.7 

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    Event date: 2017.9

    Language:Japanese  

    Venue:広島市   Country:Japan  

  • 予防・国民への啓発.久山町研究から考える脳・心血管イベント予防対策.

    二宮利治

    全国高血圧領域 TOPICS Web講演会  2017.7 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 慢性腎臓病患者における心血管病リスク:久山町研究の成績より<シンポジウム>脳心腎連関とCKD.

    二宮利治

    第49回日本動脈硬化学会総会・学術集会  2017.7 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡市   Country:Japan  

  • 健康寿命社会の実現を目指した大規模認知症コホート研究<日本神経科学学会AMED共催シンポジウム>大規模データベース、バイオリソースを用いた精神神経疾患研究の新展開.

    二宮利治

    第40回日本神経科学大会  2017.7 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:千葉   Country:Japan  

  • 認知症予防における糖尿病の重要性:久山町研究.

    二宮利治

    第16回福岡糖尿病治療研究会  2017.7 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • Associations of objectively measured sedentary time with metabolic syndrome in a general Japanese population: the Hisayama Study.<poster> International conference

    Honda T, Kishimoto H, Mukai N, Hata J, Yoshida D, Ohara T, Kumagai S, Kiyohara Y, Ninomiya T

    6th International Congress on Physical Activity and Public Health in Bangkok, Thailand,  2017.11 

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    Event date: 2017.6

    Language:English  

    Venue:Bangkok,Thailand   Country:Thailand  

  • The association of albuminuria and kidney dysfunction with the risk of the major dementia subtypes in a Japanese community-based population: the Hisayama Study.<poster> International conference

    Takae K, Hata J, Ohara T, Nagata M, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T

    Kidney Week 2016, Chicago, IL  2016.11 

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    Event date: 2017.6

    Language:English  

    Venue:Chicago   Country:United States  

  • 健康長寿社会の実現を目指した大規模認知症コホート研究.

    二宮利治

    脳とこころの研究 第二回公開シンポジウム  2017.3 

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    Event date: 2017.6

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域住民における脳卒中再発率の時代的推移:久山町研究.

    由比智裕、秦 淳、古田芳彦、向井直子、吾郷哲朗、北園孝成、清原 裕、二宮利治

    第42回日本脳卒中学会学術集会  2017.3 

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    Event date: 2017.6

    Language:Japanese  

    Venue:大阪市   Country:Japan  

  • Identification of Risk Factors for Dementia in a Japanese Community: the Hisayama Study.

    二宮利治

    第81回日本循環器学会学術集会  2017.3 

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    Event date: 2017.6

    Language:Japanese  

    Venue:金沢市   Country:Japan  

  • わが国における糖尿病と関連疾患の疫学調査:久山町研究の成績より.

    二宮利治

    Takeda DM Multi-care Seminar  2017.3 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 慢性期循環器疾患患者における死亡リスク予測モデルの開発:バイオバンク・ジャパン<シンポジウム>オーダーメイド医療の実現プログラム.

    二宮利治

    オーダーメイド医療の実現プログラム平成29年度一般公開シンポジウム  2017.3 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 認知症の疫学研究~久山町研究の成績より~.

    二宮利治

    国立社会保障・人口問題研究所研究会  2017.3 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:東京   Country:Japan  

  • Prevension of dementia using database of Hisayama study.

    Ninomiya T

    Tohoku Forum on Aging Science  2017.5 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:仙台市   Country:Japan  

  • 尿酸と慢性腎臓病、心血管病:久山町研究の成績を中心に.

    二宮 利治

    日本内科学会九州支部主催第317回九州地方会第59回九州支部生涯教育講演会  2017.5 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:沖縄   Country:Japan  

  • 地域住民における血糖関連指標とアルツハイマー病発症との関連:久山町研究

    向井直子、小原知之、秦 淳、平川洋一郎、吉田大悟、岸本裕歩、古賀正史、中村宇大、北園孝成、清原 裕、二宮利治

    第60回日本糖尿病学会年次学術集会  2017.5 

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    Event date: 2017.6

    Language:Japanese  

    Venue:名古屋   Country:Japan  

  • 健康長寿を目指す上での日本の課題~久山町研究の成績より<シンポジウム>健康長寿を目指した健康リスクマネージメント.

    二宮利治

    第71回日本栄養・食糧学会大会  2017.5 

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    Event date: 2017.6

    Language:Japanese  

    Venue:宜野湾市   Country:Japan  

  • 医療者に必要な疫学・統計学.

    二宮利治

    第60回日本腎臓学会学術総会  2017.5 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:仙台市   Country:Japan  

  • 心・脳血管病のレジストリーリアルワールドエビデンスを知る.

    二宮利治

    第4回日本心血管脳卒中学会学術集会  2017.6 

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    Event date: 2017.6

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 地域一般住民における脳卒中再発率の時代的推移:久山町研究.

    由比智裕、秦 淳、古田芳彦、向井直子、平川洋一郎、吾郷哲朗、北園孝成、清原 裕、二宮利治

    第4回日本心血管脳卒中学会学術集会  2017.6 

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    Event date: 2017.6

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 認知症の疫学研究:久山町研究の成績より.

    二宮利治

    平成28年度第4回福岡市勤務医会学術講演会  2017.6 

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    Event date: 2017.3 - 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 消化管出血をきたし剖検にて診断しえた全身性アミロイドーシスの一例:久山町剖検例における疫学的知見を加えて.

    東岡真由、向井直子、梅原 薫、山田裕一、秦 淳、平川洋一郎、孝橋賢一、小田義直、北園孝成、二宮利治

    第27回日本老年医学会九州地方会  2017.3 

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    Event date: 2017.3

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 地域住民を対象とした疫学研究(久山町研究)-高尿酸血症と心血管病・CKDとの関係を中心に-.<特別講演>

    二宮利治

    Health checkup Study Forum  2017.2 

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    Event date: 2017.3

    Language:Japanese  

    Venue:鹿児島市   Country:Japan  

  • Uric acid as a risk factor for CKD in a Japanese Community -the Hisayama Study. International conference

    Ninomiya T

    Uric Acid and Cardio-Kidney Disease Forum 2017 in Asia  2017.2 

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    Event date: 2017.3

    Language:English  

    Venue:大阪市   Country:Japan  

  • 地域医療セミナー.<座長>

    Ninomiya T

    日本慢性疾患重症化予防学会 第三回年次学術集会  2017.2 

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    Event date: 2017.3

    Language:Japanese  

    Venue:西宮市   Country:Japan  

  • 慢性腎臓病(CKD)における早期診断・治療の重要性.<講演>

    二宮 利治

    東区内科医会学術講演会  2017.2 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 血清尿酸値と慢性腎臓病発症の関係~久山町研究の成績より.<ランチョンセミナー>

    二宮 利治

    第7回日本腎臓リハビリテーション学会学術集会  2017.2 

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    Event date: 2017.3

    Language:Japanese  

    Venue:つくば市   Country:Japan  

  • 慢性期循環器疾患患者における死亡リスク予測モデルの開発:バイオバンク・ジャパン.

    秦 淳、永井亜貴子、鎌谷洋一郎、玉腰暁子、山縣然太朗、武藤香織、松田浩一、久保充明、清原 裕、二宮利治

    第27回日本疫学会学術総会  2017.1 

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    Event date: 2017.2

    Language:Japanese  

    Venue:甲府市   Country:Japan  

  • 血清尿酸値と慢性腎臓病発症の関係~久山町研究の成績より.

    二宮利治

    フェブリク®錠発売5周年記念講演会  2017.1 

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    Event date: 2017.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡市   Country:Japan  

  • 認知症の疫学;久山町研究の成績から.

    二宮利治

    日本認知症ケア学会 九州・沖縄1地域部会Ⅰ(福岡)講演・事例検討会  2017.1 

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    Event date: 2017.2

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 地域住民における食行動と肥満の関連:久山町研究.

    石田有紀、實藤愛梨、吉田大悟、持松可奈子、山下友紀子、上安由里恵、岸本裕歩、角森輝美、稲永みき、物袋由美子、二宮利治

    第5回日本公衆衛生看護学会学術集会  2017.1 

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    Event date: 2017.2

    Language:Japanese  

    Venue:仙台市   Country:Japan  

  • 牛乳・乳製品摂取量と高血圧発症との関係:久山町研究.

    大石絵美、坂田智子、吉田大悟、向井直子、秦 淳、岸本裕歩、大坪俊夫、北園孝成、清原 裕、二宮利治

    第27回日本疫学会学術総会  2017.1 

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    Event date: 2017.2

    Language:Japanese  

    Venue:甲府市   Country:Japan  

  • 日本臨床疫学会の会員制度等についての説明.

    二宮利治

    日本臨床疫学会発足記念講演会  2016.12 

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    Event date: 2017.1

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 疾病予防における血清EPA/AA比の重要性:久山町研究.

    二宮利治

    岡山脂肪酸セミナー  2016.11 

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    Event date: 2017.1

    Language:Japanese  

    Venue:岡山市   Country:Japan  

  • 久山町研究から見えてきたもの.

    二宮利治

    第34回日本神経治療学会総会  2016.11 

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    Event date: 2017.1

    Language:Japanese  

    Venue:米子市   Country:Japan  

  • CKDと心疾患の関係:久山町研究.

    二宮利治

    Samsca Heart Forum 2016 in Fukuoka  2016.11 

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    Event date: 2017.1

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 認知症の疫学研究:久山町研究.

    二宮利治

    第14回島原薬剤師地域連携研究会  2016.11 

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    Event date: 2017.1

    Language:Japanese  

    Venue:島原市   Country:Japan  

  • 久山町研究の最新の話題(認知症関連).

    二宮利治

    認知症専門医フォーラム2016  2016.11 

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    Event date: 2017.1

    Language:Japanese  

    Venue:東京   Country:Japan  

  • これからの日本人の高血圧治療について~久山町研究から見る現状と課題~.

    二宮利治

    第27回サザンキドニーカンファランス  2016.11 

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    Event date: 2017.1

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 地域高齢者における糖尿病が認知症発症に及ぼす影響:久山町研究.

    二宮利治

    第1回糖尿病・生活習慣病ヒューマンデータ研究会  2016.11 

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    Event date: 2017.1

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 久山町研究から見えてきたもの~脳卒中・認知症の疫学研究を中心に~.

    二宮利治

    神戸大学立証検査医学分野(シスメックス寄付講座)定例報告会  2016.12 

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    Event date: 2017.1

    Language:Japanese  

    Venue:神戸市   Country:Japan  

  • 健康・長寿を目指す日本人の挑戦~久山町研究が世界へ発信してきたもの~.

    二宮利治

    第31回日本国際保健医療学会市民公開講座  2016.12 

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    Event date: 2017.1

    Language:Japanese  

    Venue:久留米市   Country:Japan  

  • 幼少期の被養育体験は成人後の睡眠障害に関連する:久山町研究.<ポスター>

    二宮利治

    第21回日本心療内科学会総会・学術大会  2016.12 

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    Event date: 2017.1

    Language:Japanese  

    Venue:奈良市   Country:Japan  

  • 脳梗塞危険因子と認知症:久山町研究の成績より.

    二宮利治

    第21回岩手神経疾患研究会  2016.12 

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    Event date: 2017.1

    Language:Japanese  

    Venue:盛岡市   Country:Japan  

  • 食事と脳卒中および認知症の関係:久山町研究.

    二宮利治

    中村学園大学大学院栄養科学研究科主催第25回アジア栄養科学ワークショップ  2016.12 

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    Event date: 2017.1

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 地域住民における運動と生活習慣病の疫学:久山町研究<シンポジウム>未病予防の幹となる生活のなかの運動の包括的位置づけ.

    岸本裕歩, 秦 淳, 小原知之, 吉田大悟, 二宮利治

    第23回日本未病システム学会学術総会.  2016.11 

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    Event date: 2016.12

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 心臓病を予防する:日本の長期観察研究から学ぶこと.

    二宮利治

    第64回日本心臓病学会学術集会.  2016.9 

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    Event date: 2016.12

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 心血管病の新しい危険因子としてのバイオマーカー:久山町研究.

    秦 淳, 二宮利治

    第64回日本心臓病学会学術集会.  2016.9 

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    Event date: 2016.12

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 食事と脳卒中および認知症の関係:久山町研究.

    二宮利治

    日本農芸化学会創立100周年に向けたシンポジウム  2016.10 

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    Event date: 2016.12

    Language:Japanese  

    Venue:京都市   Country:Japan  

  • 糖尿病性腎症の疫学研究

    二宮利治

    第46回日本腎臓学会西部学術大会  2016.10 

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    Event date: 2016.12

    Language:Japanese  

    Venue:宮崎市   Country:Japan  

  • 地域住民における血清ビタミンD値が総死亡および死因別死亡に与える影響:久山町研究.

    梅原 薫, 向井直子, 秦 淳, 平川洋一郎, 吉田大悟, 岸本裕歩, 清原 裕, 二宮利治

    第75回日本公衆衛生学会総会  2016.10 

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    Event date: 2016.12

    Language:Japanese  

    Venue:大阪市   Country:Japan  

  • 高齢者の低栄養問題と低栄養対策として摂取すべき牛乳・乳製品の可能性.

    二宮利治

    第75回日本公衆衛生学会総会  2016.10 

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    Event date: 2016.12

    Language:Japanese  

    Venue:大阪市   Country:Japan  

  • 地域一般住民における血清EPA/AA比と抑うつ症状の関連:久山町研究.

    柴田舞欧, 吉田大悟, 秦 淳, 清原 裕, 二宮利治

    第75回日本公衆衛生学会総会  2016.10 

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    Event date: 2016.12

    Language:Japanese  

    Venue:大阪市   Country:Japan  

  • 未病と循環器疾患の管理のあり方.

    二宮利治

    第23回日本未病システム学会学術総会.  2016.11 

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    Event date: 2016.12

    Language:Japanese  

    Country:Japan  

  • 認知症予防における牛乳・乳製品摂取の有用性:久山町研究.

    二宮利治

    第23回日本未病システム学会学術総会.  2016.11 

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    Event date: 2016.12

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 地域恒例住民における微小脳出血の有病率とその危険因子:久山町研究.<ポスター>

    由比智裕, 秦 淳, 向井直子, 小原知之, 平林直樹, 古田芳彦, 吾郷哲朗, 北園孝成, 清原 裕, 二宮利治

    第23回日本未病システム学会学術総会.  2016.11 

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    Event date: 2016.12

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 幼少期の被養育体験は成人後の睡眠障害に関連する:久山町研究.

    柴田舞欧, 細井昌子, 安野広三, 河田 浩, 岩城理恵, 澤本良子, 久保千春, 須藤信行, 清原 裕, 二宮利治

    第23回日本未病システム学会学術総会  2016.11 

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    Event date: 2016.12

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 地域住民における座位時間と糖尿病の関連:久山町研究.

    本田貴紀, 岸本裕歩, 向井直子, 秦 淳, 吉田大悟, 平川洋一郎, 柴田舞欧, 小原知之, 熊谷秋三, 清原 裕, 二宮利治

    第23回日本未病システム学会学術総会.  2016.11 

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    Event date: 2016.12

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • これからの日本人の高血圧治療について~久山町研究から見る現状と課題~

    二宮利治

    Hypertension Conference in 横浜  2016.9 

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    Event date: 2016.12

    Language:Japanese  

    Venue:横浜市   Country:Japan  

  • 地域一般住民における睡眠時無呼吸症候群患者の受療行動に関連する因子の検討.

    呉 茜, 吉田 大悟, 半田 早希子, 柴田 舞欧, 澤渡 浩之, 藤田 香奈恵, 西坂 麻里, 細井 昌子, 鳩野 洋子, 安藤 眞一, 清原 裕, 二宮 利治, 樗木 晶子

    日本睡眠学会第41回定期学術集会.  2016.7 

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    Event date: 2016.12

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 当研究室の大学院生の研究内容.①家庭血圧の日間変動と認知症発症との関連:久山町研究.②妊婦における食塩摂取量、血圧との周産期予後との関連についての検討.③内皮由来過分極因子(EDHF)について.

    大石 絵美, 井上 美奈子, 関 拓紀

    第15回高血圧イブニングセミナー.  2016.7 

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    Event date: 2016.12

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 地域一般住民における気流制限と頸動脈内膜中膜複合体厚(IMT)の関係:久山町研究.

    工藤国弘, 秦 淳, 松本幸一郎, 春藤祐樹, 福山 聡, 井上博雅, 清原 裕, 二宮利治, 中西洋一

    第77回日本呼吸器学会・日本結核病学会・日本サルコイドーシス/肉芽腫性疾患学会.  2016.7 

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    Event date: 2016.12

    Language:Japanese  

    Venue:久留米市   Country:Japan  

  • エビデンスから見た糖尿病診療の重要性~久山町研究の成績より~.

    二宮 利治

    第6回糖尿病 UP TO DATA.  2016.7 

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    Event date: 2016.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:松山市   Country:Japan  

  • 認知症の疫学研究:久山町研究.

    二宮 利治

    第59回神経内科懇話会.  2016.8 

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    Event date: 2016.12

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 福岡県久山町における認知症の疫学:久山町研究<シンポジウム>未病と認知症の一次予防.

    小原知之, 二宮利治

    第23回日本未病システム学会学術総会  2016.11 

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    Event date: 2016.11 - 2016.12

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • 一過性脳虚血発作(TIA)の発症率・危険因子・予後の時代的推移:久山町研究.

    古田芳彦, 秦 淳, 向井直子, 吾郷哲朗, 北園孝成, 清原 裕, 二宮利治

    第23回日本未病システム学会学術総会.  2016.11 

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    Event date: 2016.11 - 2016.12

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • Risk of stroke in kidney disease<Symposium>Epidemiology of Stroke. International conference

    Ninomiya T

    10th APSAVD Congress  2016.11 

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    Event date: 2016.11

    Language:English  

    Venue:Tokyo   Country:Japan  

  • Epidemiology of dementia in a Japanese Community: the Hisayama Study<symposium>Dementia and stem cell. International conference

    Ninomiya T

    2016 PNU-Kyushu Univ. joint symposium,  2016.7 

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    Event date: 2016.11

    Language:English  

    Venue:Korea   Country:Japan  

  • Affecting Factors to Get the Residents with Sleep Disordered Breathing into Medical Treatments. International conference

    Qian W, Yoshida D, Handa S, Shibata M, Sawatari H, Fujita K, Nishizaka M, Hosoi M, Ando S, Kiyohara Y, Ninomiya T, Chisyaki A

    1st Annual Scientific Conference of the European Cardiosleep Society,  2016.4 

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    Event date: 2016.11

    Language:English  

    Venue:Prague, Czech Republic   Country:Japan  

  • 沖縄における医療分野の研究開発の推進~西普天間住宅地区跡地における国際医療拠点構想及びOHMIC構想を踏まえて~ International conference

    洪 実, 二宮 利治, 菱山 豊, 前田 士郎, 藤田 次郎, ウルフ・スコグランド

    「沖縄における医療分野の研究開発の推進」  2016.6 

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    Event date: 2016.11

    Language:Japanese  

    Venue:沖縄   Country:Japan  

  • 地域住民における認知症の疫学研究:福岡県久山町研究. International conference

    二宮 利治

    国際シンポジウム「沖縄における医療分野の研究開発の推進」  2016.6 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:沖縄   Country:Japan  

  • 一般住民におけるアルブミン尿と認知症発症の関係:久山町研究.

    髙江 啓太, 永田 雅治, 小原 知之, 秦 淳, 鶴屋 和彦, 北園 孝成, 清原 裕, 二宮 利治

    第59回日本腎臓学会学術総会.  2016.6 

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    Event date: 2016.11

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • 一般住民における血清尿酸値と心血管病死亡との関連:久山町研究.

    坂田 智子, 秦 淳, 向井 直子, 吉田 大悟, 北園 孝成, 清原 裕, 二宮 利治:

    第52回日本循環器病予防学会学術集会  2016.6 

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    Event date: 2016.11

    Language:Japanese  

    Venue:埼玉   Country:Japan  

  • 一般住民の連続剖検例における腎機能低下と左室肥大の関係:久山町研究.

    伊豆丸 堅祐, 永田 雅治, 中島 豊, 中野 敏明, 鶴屋 和彦, 小田 義直, 北園孝成, 清原 裕, 二宮 利治

    第59回日本腎臓学会学術総会.  2016.6 

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    Event date: 2016.11

    Language:Japanese  

    Country:Japan  

  • “過去50年”の変遷から

    二宮 利治

    全国高血圧領域 Topics Web講演会  2016.7 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • Incidence, risk factors, and prognosis of transient ischemic attack in a general Japanese population: the Hisayama Study International conference

    Furuta Y, Hata J, Nagata M, Mukai N, Ago T, Kitazono T, Kiyohara Y, Ninomiya T

    Asia Pacific Stroke Conference 2016, Brisbana, Qld.  2016.7 

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    Event date: 2016.11

    Language:English  

    Country:Australia  

  • 疾病予防における血清EPA/AA比の重要性:久山町研究の成績より

    二宮 利治

    第48回日本動脈硬化学会総会・学術集会  2016.7 

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    Event date: 2016.11

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 認知症~わが国の現状とその対策

    二宮利治

    第26回矢巾町健康福祉まつり市民公開講座  2016.10 

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    Event date: 2016.10 - 2016.12

    Language:Japanese  

    Venue:岩手県紫波郡   Country:Japan  

  • 認知症の疫学研究:久山町研究.

    二宮利治

    第27回日本老年医学会・東北地方会  2016.10 

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    Event date: 2016.10 - 2016.12

    Language:Japanese  

    Venue:盛岡市   Country:Japan  

  • エビデンスから見た糖尿病診療の重要性.

    二宮利治

    第120回仙台心臓血管研究会HM高等教育セミナー.  2016.10 

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    Event date: 2016.10 - 2016.12

    Language:Japanese  

    Venue:仙台市   Country:Japan  

  • <臨床研究セミナー>良い臨床研究を行うため.

    二宮利治

    第46回日本腎臓学会西部学術大会.  2016.10 

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    Event date: 2016.10 - 2016.12

    Language:Japanese  

    Venue:宮崎市   Country:Japan  

  • 認知症の疫学研究:久山町研究.

    二宮 利治

    第59回神経内科懇話会  2016.8 

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    Event date: 2016.10

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 地域一般住民における睡眠時無呼吸症候群患者の受療行動に関連する因子の検討.

    呉 茜, 吉田 大悟, 半田 早希子, 柴田 舞欧, 澤渡 浩之, 藤田 香奈恵, 西坂 麻里, 細井 昌子, 鳩野 洋子, 安藤 眞一, 清原 裕, 二宮 利治, 樗木 晶子

    日本睡眠学会第41回定期学術集会.  2016.7 

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    Event date: 2016.10

    Language:Japanese  

    Venue:東京   Country:Japan  

  • 当研究室の大学院生の研究内容.①家庭血圧の日間変動と認知症発症との関連:久山町研究.②妊婦における食塩摂取量、血圧との周産期予後との関連についての検討.③内皮由来過分極因子(EDHF)について.

    大石 絵美, 井上 美奈子, 関 拓紀

    第15回高血圧イブニングセミナー.  2016.7 

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    Event date: 2016.10

    Language:Japanese  

    Venue:福岡市   Country:Japan  

  • エビデンスから見た糖尿病診療の重要性~久山町研究の成績より~.

    二宮 利治

    第6回糖尿病 UP TO DATA.  2016.7 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:松山   Country:Japan  

  • 糖尿病とがん〜新たな糖尿病合併症〜

    二宮 利治

    平成27年度がん征圧の集い  2016.9 

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    Event date: 2016.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 久山町研究からみた認知症予防<シンポジウム>認知症予防の新展開.

    小原知之、二宮利治、清原 裕

    第29回日本老年学会総会、横浜市、2015.6  2015.6 

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    Event date: 2016.8

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • Epidemiology of dementia in an elderly Japanese population: the Hisayama Study<symposium>Epidemiology & Prevention.

    Ohara T, Kiyohara Y, Ninomiya T

    9th International Congress of Asian Society Against Dementia, Kumamoto, Japan, 2015.9  2015.9 

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    Event date: 2016.8

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:熊本   Country:Japan  

  • 生活習慣病予防対策の重要性~久山町研究の成績から~

    二宮 利治

    Primary Care Seminar  2015.9 

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    Event date: 2016.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:宇部   Country:Japan  

  • 糖尿病予防対策の重要性:久山町研究の成績から

    二宮 利治

    第4回CDE筑後更新のための必修講演会  2015.9 

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    Event date: 2016.8

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡県久留米市   Country:Japan  

  • 循環器におけるEPA介入のタイミングを考える:心血管病の予防因子としてのEPA〜久山町研究の成績から〜

    二宮 利治

    全国EPA講演会  2015.10 

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    Event date: 2016.8

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • CKDと動脈硬化性疾患:久山町研究.

    二宮 利治

    第16回大阪動脈硬化性疾患フォーラム  2015.10 

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    Event date: 2016.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:大阪   Country:Japan  

  • Elevated 2-hour post-load glucose levels and longer duration of diabetes are risk factors for hippocampal atrophy in elderly Japanese: the Hisayama Study. International conference

    Hirabayashi N, Hata J, Ohara T, Mukai N, Nagata M, Shibata M, Goto S, Furuta Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Kiyohara Y, Ninomiya T

    Announcing the American Diabetes Association's 76th Scientific Sessions,  2016.6 

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    Event date: 2016.6

    Language:English   Presentation type:Oral presentation (general)  

    Venue:New Orleans, Louisiana   Country:United States  

  • 高齢者が摂取すべき高栄養食品としての牛乳の可能性.

    二宮 利治

    明治乳業マスコミ向けセミナー.  2016.3 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:東京   Country:Japan  

  • 循環器疾患におけるバイオマーカー研究~久山町研究の成績から~.

    二宮 利治

    神戸脂質代謝研究会.  2016.4 

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    Event date: 2016.6

    Language:Japanese  

    Venue:神戸   Country:Japan  

  • 糖尿病の予防対策の重要性:新たな合併症.

    二宮 利治

    オリックス生命代理店研修会.  2016.4 

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    Event date: 2016.6

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • Epidemiological burden of metabolic disorders in a Japanese community:the Hisayama Study.

    Ninomiya T

    ICRNM2016  2016.4 

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    Event date: 2016.6

    Language:Japanese  

    Venue:沖縄   Country:Japan  

  • 臨床・疫学研究の進め方:久山町研究のCKD研究の成績を中心に.

    二宮 利治

    BRIGHTEN中部エリアミーティング.  2016.5 

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    Event date: 2016.6

    Language:Japanese  

    Venue:神戸   Country:Japan  

  • 地域住民における認知症の疫学研究:久山町研究<シンポジウム>本邦の認知症大規模コホート研究:何を目指す?.

    二宮 利治

    第57回日本神経学会学術大会.  2016.5 

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    Event date: 2016.6

    Language:Japanese  

    Venue:神戸   Country:Japan  

  • 生活習慣病重症化予防のためのCKD対策の重要性~久山町研究の成果~.

    二宮 利治

    第63回福岡県公衆衛生学会  2016.5 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡   Country:Japan  

  • 地域高齢者における認知症と孤独感の関連:久山町研究.

    柴田舞欧, 細井昌子, 平林直樹, 安野広三, 須藤信行, 清原 裕, 二宮利治

    第57回日本心身医学会総会ならびに学術講演会.  2016.6 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:仙台   Country:Japan  

  • これからの久山町研究.

    二宮 利治

    久山町制60周年記念事業生活習慣病予防講演会.  2016.5 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 地域高齢者における糖尿病と海馬萎縮との関係:久山町研究<シンポジウム>目に見えるストレス:ニューロイメージング心身医学の新展開.

    平林直樹, 秦 淳, 須藤信行, 清原 裕, 二宮利治

    第57回日本心身医学会総会ならびに学術講演会.  2016.6 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:仙台   Country:Japan  

  • 地域高齢者における野菜・果実の摂取と認知機能の関係:久山町研究.

    吉田大悟, 津野崎希, 小原知之, 岸本裕歩, 秦 淳, 柴田舞欧, 向井直子, 北園孝成, 清原 裕, 二宮利治

    第58回日本老年医学会学術集会.  2016.6 

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    Event date: 2016.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢   Country:Japan  

  • 循環器疾患におけるバイオマーカーの活用.

    二宮 利治

    第80回日本循環器学会学術集会.  2016.3 

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    Event date: 2016.5

    Language:Japanese  

    Venue:宮城   Country:Japan  

  • 地域住民における認知症とその危険因子の時代的推移:久山町研究.

    二宮 利治

    第56回日本神経病理学会総会学術研究会.  2015.6 

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    Event date: 2016.5

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 末消動脈疾患と心血管病発症の関係:久山町研究.

    二宮 利治

    第15回臨床血圧脈波研究会.  2015.6 

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    Event date: 2016.5

    Language:Japanese  

    Venue:大阪   Country:Japan  

  • The relation between dietary pattern and dementia: the Hisayama Study.

    Ninomiya T

    The 7th International Conference on Nutrition and Aging,  2015.9 

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    Event date: 2016.5

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:Tokyo   Country:Japan  

  • 地域住民における認知症の疫学研究:久山町研究.

    二宮 利治

    第34回日本認知症学会学術集会.  2015.10 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:青森   Country:Japan  

  • 認知症800万人時代(今後の展望について).

    二宮 利治

    第29回日本臨床内科医学会. 2015年10月11日,  2015.10 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:熊本   Country:Japan  

  • 地域住民における慢性腎臓病と心血管リスク.

    二宮 利治

    第22回日本未病システム学会学術総会.  2015.10 

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    Event date: 2016.5

    Language:Japanese  

    Venue:札幌   Country:Japan  

  • 久山町研究からみた認知症:認知症予防における身体活動・運動の意義-疫学からの実践まで-.

    二宮 利治

    第74回日本公衆衛生学会総会.  2015.11 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:長崎   Country:Japan  

  • 介護予防のための運動、栄養、社会環境づくり:一次予防のエビデンス.

    二宮利治, 横山友里, 藤原佳典

    日本介護福祉・健康づくり学会第3回大会.  2015.11 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 糖尿病性腎症の臨床・疫学研究.

    二宮 利治

    第53回日本糖尿病学会九州地方会.  2015.11 

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    Event date: 2016.5

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 臨床研究における統計解析の注意点.

    二宮 利治

    第50回糖尿病学の進歩.  2016.2 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 食事と認知症の関係:久山町研究

    二宮 利治

    第55回日本心身医学会九州地方会.  2016.1 

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    Event date: 2016.5

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 疾病予防における血清EPA/AAの重要性:久山町研究の成績より.

    二宮 利治

    第3回JFAS(Japan/ Joy of Fatty Acids Secrets/ Society)  2016.3 

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    Event date: 2016.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • Innovation in Diabetes 2012 “New horizons in treatment and prevention”: Diabetes and dementia Invited International conference

    Ninomiya T

    The Steno Symposium  2012.5 

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    Event date: 2012.5

    Presentation type:Symposium, workshop panel (public)  

    Venue:Copenhagen   Country:Denmark  

  • 認知症・要介護予防におけるロコモ・フレイル対策の重要性:久山町研究.

    二宮利治

    令和5年度奈良県地域包括・在宅介護支援センター協議会第2回セミナー  2024.3 

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    Language:Japanese  

    Venue:橿原市   Country:Japan  

  • 地域住民における認知症の疫学研究:久山町研究・抗加齢医学に疫学がどう貢献するか

    二宮 利治

    第15回日本抗加齢医学会総会  2015.5 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • Chronic kidney disease and cardiovascular disease in the general Japanese population: The Hisayama study. International conference

    Ninomiya T, Kiyohara Y, Kubo M, Hirakata H, Iida M.

    3rd World Congress of Nephrology.  2005.6 

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    Presentation type:Oral presentation (general)  

    Venue:Singapore   Country:Singapore  

  • 一般住民における慢性腎臓病と心血管病発症の関係:久山町研究. Invited

    二宮 利治, 清原 裕, 久保 充明, 平方 秀樹, 飯田 三雄.

    第35回日本腎臓学会西部学術大会.  2005.9 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:長崎   Country:Japan  

  • Impact of metabolic syndrome on the development of chronic kidney disease in a general Japanese population: the Hisayama study. International conference

    Ninomiya T, Kiyohara Y, Kubo M, Hirakata H, Iida M.

    The 6th International Diabetes Federation Western Pacific Region Congress.  2005.10 

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    Presentation type:Oral presentation (general)  

    Venue:Bangkok   Country:Thailand  

  • わが国における慢性腎臓病(CKD)の現状と対策. 一般住民における慢性腎臓病の現状とその予後:久山町研究. Invited

    二宮 利治, 清原 裕, 平方 秀樹, 飯田 三雄

    第51回日本透析医学会学術集会.  2006.6 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • Proteinuria as a predictor of stroke- a systematic review. International conference

    Ninomiya T, Perkovic V, Verdon C, Barzi F, Craig J, Cass A, Huxley R.

    The 43rd Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology.  2007.9 

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    Presentation type:Oral presentation (general)  

    Venue:Gold coast   Country:Australia  

  • The efficacy of lower blood pressure goals on the prevention of stroke in chronic kidney disease: data from the PROGRESS study. International conference

    Ninomiya T, Perkovic V, Gallagher M, Jardine M, Cass A, Neal B, Macmahon S, Chalmers J.

    The 43rd Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology.  2007.9 

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    Presentation type:Oral presentation (general)  

    Venue:Gold coast   Country:Australia  

  • Effects of the endpoint adjudication process on the results of the Perindopril Protection Against recurrent Stroke Study (PROGRESS). International conference

    Ninomiya T, Donnan G, Anderson N, Bladin C, Chambers B, Gordon G, Sharpe N, Woodward M, Neal B.

    The 3rd International Clinical Trials Symposium.  2007.9 

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    Presentation type:Oral presentation (general)  

    Venue:Sydney   Country:Australia  

  • Proteinuria as a predictor of stroke- a systematic review. International conference

    Ninomiya T, Perkovic V, Verdon C, Barzi F, Craig J, Cass A, Anderson C, Huxley R.

    American Society of Nephrology Renal Week 2007.  2007.11 

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    Presentation type:Oral presentation (general)  

    Venue:San Francisco   Country:United States  

  • Lower blood pressure and the risk of stroke in chronic kidney disease: results of the PROGRESS trial. International conference

    Ninomiya T, Perkovic V, Gallagher M, Jardine M, Cass A, Neal B, MacMahon S, Chalmers J.

    High Blood Pressure Research Council of Australia.  2007.12 

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    Presentation type:Oral presentation (general)  

    Venue:Adelaide   Country:Australia  

  • Independent Impact of Albuminuria and Kidney Function on Cardiovascular Risk in Patients with Type 2 Diabetes: Results from the ADVANCE Trial. International conference

    Ninomiya T, Perkovic V, de Galan BE, Patel Zoungas S, Jardine M, Patel A, Cass A, Neal B, Cooper M, MacMahon S, Chalmers J.

    High Blood Pressure Research Council of Australia.  2008.12 

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    Presentation type:Oral presentation (general)  

    Venue:Melbourne   Country:Australia  

  • シンポジウム1 「慢性腎臓病(CKD)と脳心血管疾患」 Chronic kidney disease and blood pressure on the risk of cardiovascular disease. Invited

    二宮 利治, 清原 裕.

    第41回日本動脈硬化学会総会.  2009.7 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:下関   Country:Japan  

  • 特別企画1「日本のエビデンスをつくる:JALS」 慢性腎臓病が心血管病に及ぼす影響: Japan Arteriosclerosis Longitudinal (JALS) 研究. Invited

    二宮 利治, 清原 裕.

    第32回日本高血圧学会総会.  2009.10 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:滋賀   Country:Japan  

  • ワークショップ3「心腎連関:最近の知見」 一般住民における慢性腎臓病が虚血性心疾患に与える影響. Invited

    二宮 利治, 清原 裕.

    第39回日本腎臓学会西部学術大会.  2009.10 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:和歌山   Country:Japan  

  • わが国の高血圧の代表的疫学コホートとその成果 高齢者社会における高血圧管理のあり方:久山町研究 Invited

    二宮 利治, 清原 裕

    第33回 日本高血圧学会総会  2010.10 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 血圧値に基づいた心血管病リスク層別化と絶対リスク評価 Invited

    二宮 利治, 清原 裕

    第34回日本高血圧学会総会  2011.10 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:宇都宮   Country:Japan  

  • The effects of 1,25-dihydroxyvitamin D3 on the risk of death in a Japanese general population: the Hisayama Study. International conference

    Ninomiya T, Nagata M, Usui T, Kitazono T, Kiyohara Y

    The American Society of Nephrology Kidney Week 2011  2011.11 

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    Venue:Philadelphia   Country:United States  

  • Relationship between the ratio of serum eicosapentaenoic acid to arachidonic acid and the risk of death: the Hisayama Study International conference

    Ninomiya T, Doi Y, Kiyohara Y

    American Heart Association Scientific Sessions 2011  2011.11 

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    Venue:Orlando   Country:United States  

  • Development of a stroke risk prediction model for Japanese: the Japan Arteriosclerosis Longitudinal Study-Exisiting Cohorts Combine (JALS-ECC) International conference

    Ninomiya T, Kiyohara Y, Ando T, Harada A, Ohashi Y, Ueshima H

    8th Asian-Pacific Congress of Hypertension 2011  2011.11 

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    Presentation type:Oral presentation (general)  

    Venue:Taipei   Country:Taiwan, Province of China  

  • The International Symposium in Fukuoka 2012 in Commemoration of the 50th Anniversary of the Hisayama Study: II. Cardiovascular Epidemiology in the East and the West. Cardiovascular Risk Factors in Japanese: The Hisayama Study Invited

    Ninomiya T

    The 76th Annual Scientific Meeting of the Japanese Circulation Society  2012.3 

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    Presentation type:Symposium, workshop panel (public)  

    Venue:Fukuoka, Japan   Country:Japan  

  • 血中EPA/AA比と心血管病発症の関係:久山町研究

    二宮 利治, 清原 裕

    第48回日本循環器病予防学会・日本循環器管理研究協議会総会  2012.6 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 心筋梗塞、脳梗塞の疫学:欧米との比較

    二宮 利治, 清原 裕

    第44回日本動脈硬化学会総会  2012.7 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 地域住民における慢性腎臓病と心血管病リスク

    二宮 利治, 清原 裕

    第35回日本高血圧学会総会  2012.9 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋   Country:Japan  

  • 久山町研究における高齢者循環器疾患

    二宮 利治, 清原 裕

    第19回日本未病システム学会学術総会  2012.10 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:金沢   Country:Japan  

  • 日本の臨床研究の課題

    二宮 利治

    第58回日本透析医学会学術集会・総会  2013.6 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 高血圧症が動脈硬化性疾患発症に及ぼす影響:久山町研究

    二宮 利治, 清原 裕

    第36回日本高血圧学会総会  2013.10 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  • 久山町研究~脳卒中の時代的推移とその危険因子~

    二宮 利治, 清原 裕

    第55回日本神経学会学術大会  2014.5 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 久山町研究(CKDと心血管病、肥満、脂質代謝異常の関連)

    二宮 利治, 清原 裕

    第57回日本腎臓学会学術総会  2014.7 

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    Language:Japanese  

    Venue:横浜   Country:Japan  

  • Secular trends in dementia and its risk factors in a Japanese Community: the Hisayama Study Invited International conference

    Ninomiya T, Kiyohara Y

    Global Dementia Legacy Event Japan  2014.11 

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    Language:English  

    Venue:Tokyo, Japan   Country:Japan  

  • ERA-EDTA/ISN Symposium: Setting up dialysis registries: Experience with Collaboration of Dialysis Registries in Asia Invited International conference

    Ninomiya T

    The ISN World Congress of Nephrology 2015  2015.3 

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    Language:English  

    Venue:Cape Town, South Africa   Country:South Africa  

  • CKD患者の脳血管障害リスク

    二宮 利治

    第40回日本脳卒中学会総会  2015.3 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:広島   Country:Japan  

  • 心血管病の予防因子としてのEPA~久山町研究の成績から~

    二宮 利治

    第40回日本脳卒中学会総会  2015.3 

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    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:広島   Country:Japan  

  • エビデンスから見た糖尿病診療の重要性

    二宮 利治

    糖尿病治療を考える会  2015.4 

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    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東京   Country:Japan  

  • コホート研究におけるデータシェアリングの現状・課題

    二宮 利治

    文部科学省・科学技術振興機構「データシェアリングを利用した科学技術」に関する勉強会(第3回)  2015.4 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • エビデンスから見た糖尿病診療の重要性

    二宮 利治

    第51回糖尿病臨床・研究開発センター講演会  2015.4 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:徳島   Country:Japan  

  • 臨床疫学研究のすすめ方

    二宮 利治

    第4回臨床高血圧フォーラム  2015.5 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • Association between hypothalamic Alzheimer's disease pathology and clinical pictures.<poster>

    Yagita K, Honda H, Ohara T, Yamasaki R, Isobe N, Ninomiya T

    第65回日本神経学会学術大会、第19回アジア・オセアニア神経学会議  2024.5 

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    Presentation type:Poster presentation  

    Venue:東京都   Country:Japan  

  • 地域疫学研究を通した地域社会への貢献:久山町研究の経験から

    二宮利治

    日本社会薬学会第42回年会  2024.9 

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    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • 認知症発症に関連するバイオマーカー研究<特別企画3>データ連携(包括的RWD構築)最前線.

    二宮利治

    弘前大学COI-NEXT Well-beingイノベーションフォーラム2024  2024.9 

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    Language:Japanese  

    Venue:WEB  

  • 認知症予防における身体活動、社会活動の重要性~久山町研究の成績より~.

    二宮利治

    令和六年度九州大学基金「相続・遺言セミナー」  2024.10 

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    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:大阪市  

  • <教育講演12><司会>

    二宮利治

    第54回日本腎臓学会西部学術大会  2024.10 

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    Language:Japanese  

    Venue:姫路市   Country:Japan  

  • 認知症予防における筋力・運動機能維持の重要性:久山町研究の成績より.

    二宮利治

    認知症フレンドリーセンター1周年記念イベント  2024.10 

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    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 地域住民における社会的・情緒的孤独感は慢性疼痛と関連する:久山町研究.

    柴田舞欧、細井昌子、秦 淳、二宮利治

    第83回日本公衆衛生学会総会  2024.10 

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    Language:Japanese  

    Venue:札幌市   Country:Japan  

  • 地域住民における社会的・情緒的孤独感は慢性疼痛と関連する:久山町研究.

    二宮利治、柴田舞欧、秦 淳

    第83回日本公衆衛生学会総会  2024.10 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌市   Country:Japan  

  • 地域住民における社会的・情緒的孤独感は慢性疼痛と関連する:久山町研究.

    坂田智子、大石絵美、本田貴紀、柴田舞欧、秦 淳、二宮利治

    第83回日本公衆衛生学会総会  2024.10 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌市   Country:Japan  

  • 地域住民における社会的・情緒的孤独感は慢性疼痛と関連する:久山町研究.

    大石絵美、本田貴紀、古橋寛子、秦 淳、二宮利治

    第83回日本公衆衛生学会総会  2024.10 

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    Language:Japanese  

    Venue:札幌市   Country:Japan  

  • 認知症及び軽度認知障害の有病率調査並びに将来推計に関する研究.

    二宮利治

    認知症施策推進関係者会議(第2回)  2024.5 

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    Venue:東京都   Country:Japan  

  • Association of impaired olfactory identification with prevalent mild cognitive impairment and regional brain atrophy: the Hisayama Study.<poster> International conference

    Minohara T, Ohara T, Nakazawa T, Hata J, Shibata M, Ninomiya T

    Alzheimer's Association International Conference 2024, Philadelphia, PA, USA   2024.7 

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    Language:English   Presentation type:Poster presentation  

    Venue:USA   Country:United States  

  • 37-year secular trends in prevalence, incidence, and survival rate of dementia in a Japanese community: the Hisayama Study.<poster> International conference

    Tomoyuki Ohara, Toshifumi Minohara, Taro Nakazawa, Jun Hata, Mao Shibata, Toshiharu Ninomiya

    Alzheimer's Association International Conference 2024, Philadelphia, PA, USA   2024.7 

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    Language:English   Presentation type:Poster presentation  

    Venue:USA   Country:United States  

  • データを活用した健康課題の把握と評価の視点.

    二宮利治

    令和6年度第1回データヘルス研修会  2024.7 

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    Venue:福岡市   Country:Japan  

  • 地域疫学研究の成果からみた認知症の発症リスク低減の可能性:久山町研究. Invited

    二宮利治

    けんぽ共同健診協会総会、Web、2024  2024.7 

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    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:WEB  

  • 60年にわたる地域疫学研究の取組:久山町研究.

    二宮利治

    福岡歯科大学開学記念式典  2024.7 

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    Venue:福岡市   Country:Japan  

  • 疫学研究の成果からみた認知症の発症リスク低減の可能性:久山町研究.

    二宮利治

    けいはんR&Dイノベーションコンソーシアム第9回総会、Web、2024  2024.7 

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    Venue:WEB  

  • Risk assessment of arteriosclerotic disease in a general population:the Hisayama Study <KSoLA-JAS Joint Symposium>

    Ninomiya T

    第56回日本動脈硬化学会総会・学術集会  2024.7 

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    Venue:神戸市   Country:Japan  

  • 地域高齢者における慢性疼痛重症度とADL障害発症との関連:久山町研究.

    齊藤貴文、柴田舞欧、本田貴紀、平林直樹、安野広三、須藤信行、細井昌子、二宮利治

    第17回日本運動器疼痛学会  2024.11 

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    Venue:東京都   Country:Japan  

  • 地域住民におけるQT間隔延長と認知症発症との関連:久山町研究

    眞島妙子、大石絵美、本田貴紀、二宮利治

    日本臨床疫学会第7回年次学術大会  2024.11 

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    Venue:東京都   Country:Japan  

  • 地域認知症コホート研究の推進:JPSC-AD研究.

    二宮利治

    第2回認知症研究者交流会「AMEDにおけるこれからの認知症研究」、東京、2024.12  2024.12  日経新聞

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    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:東京   Country:Japan  

  • Trend in the prevalence of dementia in Japan: the Hisayama Study and the JPSC-AD study<セッション>「健康」:認知症対策の新展開~病とたたかい、共存するための方策.

    二宮利治

    第6回Nikkei Super Active Ageing Society Conference  2024.11  日経新聞

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    Venue:東京   Country:Japan  

  • 地域高齢者の認知機能低下に伴う行動・心理症状と脳容積との関係:中山町研究.

    立花亜由美、伊賀淳一、尾崎智樹、吉野祐太、山崎聖広、越智紳一郎、河邉憲太郎、堀内史枝、吉田 卓、清水秀明、森 崇明、舘脇康子、瀧 靖之、二宮利治、上野修一

    第43回日本認知症学会学術集会  2024.11  日本認知症学会

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    Presentation type:Oral presentation (general)  

    Venue:福島市   Country:Japan  

  • 地域高齢者における血清高感度CRPと認知症との関連:JPSC-AD研究.

    立花亜由美、伊賀淳一、尾崎智樹、吉田 卓、吉野祐太、清水秀明、森 崇明、古田芳彦、柴田舞欧、小原知之、秦 淳、瀧 靖之、三上達也、前田哲也、小野賢二郎、三村 將、中島健二、 竹林 実、二宮利治、上野修一

    第43回日本認知症学会学術集会、福島市、2024.11  2024.11  日本認知症学会

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    Presentation type:Oral presentation (general)  

    Venue:福島市   Country:Japan  

  • 地域高齢住民における灰白質萎縮および白質病変が認知症発症に及ぼす影響:久山町研究<シンポジウム3>血管障害から見た認知症の発症リスク低減とその社会実装.

    中澤太郎、小原知之、二宮利治

    第43回日本認知症学会学術集会  2024.11  日本認知症学会

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    Presentation type:Symposium, workshop panel (public)  

    Venue:福島市   Country:Japan  

  • <共催セミナー4>地域住民における血清グリコアルブミン測定の有用性:久山町研究.

    二宮利治

    第48回日本血液事業学会総会  2024.11  日本血液事業学会総会

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    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡市   Country:Japan  

  • 地域住民において尿中神経伝達物質減少は抑うつ症状発症に関連する:久山町研究.<ポスター>

    柴田舞欧、平林直樹、中村侑里、細井昌子、秦 淳、須藤信行、二宮利治

    第31回日本未病学会学術総会  2024.11  日本未病学会

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    Presentation type:Poster presentation  

    Venue:金沢市   Country:Japan  

  • 二次性(続発性)高血圧(薬剤性高血圧を含む)の診断・治療について.<座長>

    二宮 利治

    第31回日本未病学会学術総会  2024.11  日本未病学会

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    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:金沢市   Country:Japan  

  • コホート研究の実際と可能性<シンポジウム>データベースか?コホートか?.

    二宮 利治

    日本臨床疫学会第7回年次学術大会  2024.11  日本臨床疫学会

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    Presentation type:Symposium, workshop panel (nominated)  

    Venue:東京都   Country:Japan  

  • <デザートセミナー2>地域認知症コホート研究の最近の知見:久山町研究.

    二宮利治

    第18回日本薬局学会学術総会  2024.11  日本薬局学会

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    Venue:横浜市   Country:Japan  

  • 認知症の発症リスク低減の可能性:久山町研究およびJPSC-AD研究の知見より.

    二宮利治

    生活習慣病について考える会  2024.11 

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    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:藤沢市   Country:Japan  

  • 認知症の血漿バイオマーカーと部位別脳容積変化率との関連.

    中澤太郎、小原知之、秦 淳、本田貴紀、柴田舞欧、三上達也、前田哲也、小野賢二郎、三村 將、中島健二、伊賀淳一、竹林 実、徳田隆彦、二宮利治

    第39回日本老年精神医学会  2024.7 

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    Venue:札幌市   Country:Japan  

  • 日本人地域住民におけるpreserved ratio impaired spirometryが総死亡および認知症発症に及ぼす影響:久山町研究.

    川床健司、鷲尾康圭、岡本 勇、二宮利治

    第64回日本呼吸器学会学術講演会  2024.4 

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    Venue:横浜市   Country:Japan  

  • Mild parkinsonian signs 症例における血液バイオマーカーの関連:海士町研究

    古和久典、深田育代、中野俊也、岸 真文、和田健二、建部陽嗣、徳田隆彦、二宮利治、中島健二

    第42回日本神経治療学会学術集会  2024.11 

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    Venue:千葉市   Country:Japan  

  • 疫学研究の成果からみた認知症の発症リスク低減の可能性:久山町研究.

    けいはんなR&Dイノベーションコンソーシアム第9回総会、Web  2024.7  関西文化学術研究都市推進機構

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    Language:Japanese  

    Venue:WEB   Country:Japan  

  • 視床下部アルツハイマー病理と生前臨床像の関連:久山町研究.

    八木田 薫、本田裕之、小原知之、山﨑 亮、磯部紀子、二宮利治

    第65回日本神経病理学会総会学術研究会  2024.5 

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    Venue:下関市   Country:Japan  

  • 疫学的視点から見る認知症発症リスク低減の可能性:久山町研究<日本脳ドック学会合同シンポジウム05>認知症の早期発見と早期介入.

    二宮 利治

    第50回日本脳卒中学会学術集会  2025.3 

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    Language:Japanese  

    Venue:大阪市   Country:Japan  

  • 脳心腎連関の住民疫学:久山町研究<シンポジウム02>脳心腎関連と変貌する降圧療法.

    秦 淳、二宮利治

    第50回日本脳卒中学会学術集会  2025.3 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪市   Country:Japan  

  • 失感情症と慢性疼痛発症の関連及び抑うつ症状の影響:久山町研究.

    柴田舞欧、二宮利治、平林直樹、森崎悠紀子、安野広三、吉田大悟、秦 淳、須藤信行、細井昌子

    第54回日本慢性疼痛学会  2025.2 

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    Venue:仙台市   Country:Japan  

  • 歩行速度・食習慣別にみた医療費・介護費との関連:福岡市地域包括ケア情報プラットフォームからの報告.

    大石絵美、本田貴紀、古橋寛子、古田芳彦、秦 淳、二宮利治

    第35回日本疫学会学術総会  2025.2 

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    Venue:高知市   Country:Japan  

  • 地域高齢住民における網膜反射輝度と認知症の関連:久山町研究.

    上田瑛美、中村大輔、小原知之、園田康平、二宮利治

    第35回日本疫学会学術総会  2025.2 

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    Venue:高知市   Country:Japan  

  • 認知症予防の鍵~ひさやま健診と久山町研究の成果から~.

    二宮 利治

    第11回ひさやま健康セミナー  2025.2 

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    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:糟屋郡   Country:Japan  

  • 地域住民における乳頭周囲脈絡膜厚と緑内障の関連:久山町研究.

    藤原康太、上田瑛美、秦 淳、橋本左和子、中村 駿,、村上祐介、久保田敏昭、吉冨健志、二宮利治、園田康平

    第35回日本緑内障学会  2024.9 

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    Venue:姫路市   Country:Japan  

  • Mild parkinsonian signs 症例における血液バイオマーカーの関連:海士町研究.

    古和久典、深田育代、中野俊也、岸 真文、和田健二、建部陽嗣、徳田隆彦、二宮利治、中島健二

    第42回日本神経治療学会学術集会  2024.11 

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    Venue:千葉市   Country:Japan  

  • Secular trends in the prevalence, incidence, and mortality of dementia in a Japanese community. International conference

    Ohara T, Ninomiya T

    Asia-Pacific Psychiatry and Aging Conference 2024,   2024.11 

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    Venue:Seoul, South Korea   Country:Korea, Republic of  

  • Secular trends in the prevalence of prostate cancer over a half-century based on consecutive autopsy cases in a Japanese community: the Hisayama Study.

    Taira J, Kawatoko K, Takamatsu D, Shiota M, Ogata H, Hata J, Oishi O, Sakata S, Furuta Y, Shibata M, Oda Y, Eto M, Ninomiya T

    第112回日本泌尿器科学会総会  2025.4 

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    Venue:横浜市   Country:Japan  

  • Association of diet with the risk of stroke and dementia in a general Japanese population: the Hisayama Study. Invited International conference

    二宮 利治

    International workshop on dietary therapy for chronic kidney disease  2025.3 

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    Language:English   Presentation type:Symposium, workshop panel (nominated)  

    Venue:沖縄市   Country:Japan  

  • P-wave duration of electrocardiogram and onset of atrial fibrillation and histological atrial fibro-sis in a general Japanese: the Hisayama Study.

    前園明寛、大石絵美、加藤あさひ、阿部弘太郎、二宮利治

    第89回日本循環器学会学術集会  2025.3 

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    Venue:横浜市   Country:Japan  

  • Association between changes in serum N-terminal pro brain natriuretic peptide levels and mortality in a Japanese community: the Hisayama Study.

    加藤あさひ、大石絵美、前園明寛、阿部弘太郎、二宮利治

    第89回日本循環器学会学術集会  2025.3 

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    Venue:横浜市   Country:Japan  

  • 認知症予防における生活習慣病予防、運動機能維持の重要性:久山町研究.

    二宮 利治

    経済同友会 産業調査研究会 第2金曜グループ3月例会  2025.3 

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    Language:Japanese  

    Venue:東京都   Country:Japan  

  • 久山町研究からみた予防医学の実際.

    二宮 利治

    第26回フィジカルヘルスフォーラム  2025.3 

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    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡市   Country:Japan  

  • 地域高齢住民における無症候性脳梗塞病変の新規出現率とその危険因子:久山町研究.

    古田芳彦、秦 淳、熊本将也、本田貴紀、脇坂義信、吾郷哲朗、北園孝成、二宮利治

    第50回日本脳卒中学会学術集会  2025.3 

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    Venue:大阪市   Country:Japan  

  • Secular trends in the prevalence of prostate cancer over a half-century based on consecutive autopsy cases in a Japanese community: the Hisayama Study.

    Taira J, Kawatoko K, Takamatsu D, Shiota M, Ogata H, Hata J, Oishi O, Sakata S, Furuta Y, Shibata M, Oda Y, Eto M, Ninomiya T

    第67回日本口腔衛生学会・総会  2018.5 

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    Venue:札幌市   Country:Japan  

  • 高齢者コホート研究における心理社会的アウトカム 心理社会的因子と認知症発症の関連 地域認知症コホート研究の成績より

    小原 知之, 二宮 利治

    日本社会精神医学会雑誌  2024.8  (一社)日本社会精神医学会

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  • 高齢者の肥満型フレイルにおける脳容積の検討 JPSC-AD研究

    石塚 直樹, 赤坂 博, 佐藤 光信, 佐藤 裕里子, 細川 一貴, 本田 貴紀, 柴田 舞欧, 小原 知之, 秦 淳, 舘脇 康子, 瀧 靖之, 二宮 利治, 前田 哲也

    Dementia Japan  2023.10  (一社)日本認知症学会

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  • 食事と運動機能が認知症発症リスクに及ぼす影響 久山町研究

    二宮 利治

    日本栄養・食糧学会大会講演要旨集  2024.4  (公社)日本栄養・食糧学会

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  • 認知症評価における頭部MRI画像を用いた白質病変容積計測システムの有用性の検討

    二宮 利治, 柴田 舞欧, 秦 淳

    日本公衆衛生学会総会抄録集  2024.10  日本公衆衛生学会

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  • 認知症発症のリスク低減における筋力・運動機能維持の重要性 久山町研究

    二宮 利治

    理学療法福岡  2023.5  (公社)福岡県理学療法士会

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  • 認知症バイオマーカー研究の最新知見 認知症の血漿バイオマーカーと認知症発症との関連

    小原 知之, 二宮 利治

    Dementia Japan  2023.10  (一社)日本認知症学会

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  • 認知症の血漿バイオマーカーと部位別脳容積変化率との関連

    中澤 太郎, 小原 知之, 秦 淳, 本田 貴紀, 柴田 舞欧, 三上 達也, 前田 哲也, 小野 賢二郎, 三村 將, 中島 健二, 伊賀 淳一, 竹林 実, 徳田 隆彦, 二宮 利治

    老年精神医学雑誌  2024.7  (株)ワールドプランニング

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  • 認知症の予防・治療法を目指した本邦のコホート研究 認知症の地域疫学研究 久山町研究

    二宮 利治

    神経治療学  2023.10  (一社)日本神経治療学会

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  • 認知機能における25-OHビタミンDの関連 海士町研究

    古和 久典, 深田 育代, 中野 俊也, 岸 真文, 和田 健二, 二宮 利治, 中島 健二

    Dementia Japan  2023.10  (一社)日本認知症学会

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  • 視床下部アルツハイマー病理はBMI低値と相関する 久山町研究

    八木田 薫, 本田 裕之, 小原 知之, 山崎 亮, 磯部 紀子, 二宮 利治

    Dementia Japan  2023.10  (一社)日本認知症学会

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  • 視床下部アルツハイマー病の病理と臨床像の関連(Association between Hypothalamic Alzheimer's Disease Pathology and Clinical Pictures)

    Yagita Kaoru, Honda Hiroyuki, Ohara Tomoyuki, Yamasaki Ryo, Isobe Noriko, Ninomiya Toshiharu

    臨床神経学  2024.10  (一社)日本神経学会

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  • 血管障害からみた認知症の発症リスク低減とその社会実装 地域高齢住民における灰白質萎縮および白質病変が認知症発症に及ぼす影響 久山町研究

    中澤 太郎, 小原 知之, 二宮 利治

    Dementia Japan  2024.10  (一社)日本認知症学会

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  • 血漿認知症バイオマーカーと認知症発症の関係 地域前向きコホート研究の成績より

    小原 知之, 秦 淳, 徳田 隆彦, 本田 貴紀, 柴田 舞欧, 中路 重之, 前田 哲也, 小野 賢二郎, 三村 將, 中島 健二, 伊賀 淳一, 竹林 実, 二宮 利治

    老年精神医学雑誌  2023.10  (株)ワールドプランニング

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  • 血清脂質値の性・年齢階級別の検証 sdLDLコレステロールを中心に 久山町研究

    坂田 智子, 大石 絵美, 本田 貴紀, 柴田 舞欧, 秦 淳, 二宮 利治

    日本公衆衛生学会総会抄録集  2024.10  日本公衆衛生学会

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  • 血清angiopoietin-like protein 2(ANGPTL2)濃度と死因別死亡の関連 久山町研究

    秦 淳, 坂田 智子, 古田 芳彦, 大石 絵美, 本田 貴紀, 柴田 舞欧, 北園 孝成, 尾池 雄一, 二宮 利治

    日本循環器病予防学会誌  2024.4  (一社)日本循環器病予防学会

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  • 臓器終末像予防の為の健康寿命の延伸に向けた栄養 認知症予防における食事の重要性 久山町研究

    二宮 利治

    日本栄養・食糧学会大会講演要旨集  2022.5  (公社)日本栄養・食糧学会

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  • 脳心腎臓血管病の予防 脳卒中の危険因子とその予防

    秦 淳, 二宮 利治

    日本動脈硬化学会総会プログラム・抄録集  2022.7  (一社)日本動脈硬化学会

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  • 脳卒中予防の最前線 久山町研究の成績より

    秦 淳, 二宮 利治

    日本循環器病予防学会誌  2023.5  (一社)日本循環器病予防学会

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  • 肥満と医療費との関連 福岡市地域包括ケア情報プラットフォームからの報告

    大石 絵美, 本田 貴紀, 古橋 寛子, 秦 淳, 二宮 利治

    日本公衆衛生学会総会抄録集  2024.10  日本公衆衛生学会

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  • 老年医学における大規模データベースの活用 地域認知症コホート研究の推進

    二宮 利治

    日本老年医学会雑誌  2024.5  (一社)日本老年医学会

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  • 糖代謝異常に伴う認知症:最新知見から考察する病態メカニズム 地域住民における糖尿病と認知症発症の関係 久山町研究

    二宮 利治

    老年精神医学雑誌  2022.11  (株)ワールドプランニング

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  • 糖代謝異常に伴う認知症:最新知見から考察する病態メカニズム 地域住民における糖尿病と認知症発症の関係 久山町研究

    二宮 利治

    Dementia Japan  2022.10  (一社)日本認知症学会

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  • 筋肉・サルコペニアと肥満 日本人地域住民におけるサルコペニアの疫学 久山町研究

    秦 淳, 二宮 利治

    肥満研究  2023.11  (一社)日本肥満学会

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  • 筋トレの疫学 我が国の地域住民における筋トレの実態 久山町研究

    本田 貴紀, 二宮 利治

    体力科学  2022.2  (一社)日本体力医学会

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  • 白質病変の定量化による日本人大規模高齢者集団の食事パターンと認知症に関する研究

    陳 俐穎, 舘脇 康子, Thyreau Benjamin, 内田 和宏, 壹岐 ひかり, 中瀬 泰然, 中路 重之, 前田 哲也, 野口 もえ子[篠原], 三村 將, 中島 健二, 伊賀 淳一, 竹林 実, 二宮 利治, 瀧 靖之

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  • 白衣高血圧は心血管病発症の危険因子となるか? 久山町研究

    坂田 智子, 大石 絵美, 秦 淳, 北園 孝成, 二宮 利治

    日本高血圧学会総会プログラム・抄録集  2023.9  (NPO)日本高血圧学会

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    老年精神医学雑誌  2022.11  (株)ワールドプランニング

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    二宮 利治

    Dementia Japan  2022.10  (一社)日本認知症学会

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  • 生活習慣が認知症発症に及ぼす影響 久山町研究の成績より

    二宮 利治

    日本医学会総会会誌  2023.4  日本医学会

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  • 特定健診における動脈硬化性疾患発症リスク予測モデルの評価可能性 大規模健診・医療レセプトデータベースを用いた検討

    本田 貴紀, 陳 三妹, 石田 有紀, 木村 安美, 吉田 大悟, 二宮 利治

    健康支援  2023.2  日本健康支援学会

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  • 深層学習によるMRI画像からの咬筋測定プログラム開発及び疫学的意義に関する初期検討

    武田 研, 舘脇 康子, Benjamin Thyeau, 村中 美千帆, 阪本 真弥, 二宮 利治, 瀧 靖之

    老年精神医学雑誌  2022.11  (株)ワールドプランニング

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  • 深層学習によるMRI画像からの咬筋測定プログラム開発及び疫学的意義に関する初期検討

    武田 研, 舘脇 康子, Benjamin Thyreau, 村中 美千帆, 阪本 真弥, 二宮 利治, 瀧 靖之

    Dementia Japan  2022.10  (一社)日本認知症学会

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  • 海馬亜領域の糖尿病に対する脆弱性

    島 綾乃, 篠原 もえ子, 小松 潤史, 柴田 修太郎, 坂下 泰浩, 村松 大輝, 疋島 貞雄, ティロー・バンジャマン , 館脇 康子, 瀧 靖之, 二宮 利治, 小野 賢二郎

    臨床神経学  2023.9  (一社)日本神経学会

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  • 活動的な通勤および通勤形態と糖尿病発症リスクの関連 久山町研究

    本田 貴紀, 平川 洋一郎, 秦 淳, 陳 三妹, 柴田 舞欧, 坂田 智子, 古田 芳彦, 東岡 真由, 大石 絵美, 北園 孝成, 二宮 利治

    Journal of Epidemiology  2022.1  (一社)日本疫学会

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  • 治療中高血圧者において、室温は家庭血圧測定値に影響する 福岡高血圧コホート研究

    大森 将, 松村 潔, 大坪 俊夫, 冨永 光裕, 鍵山 俊太郎, 川崎 純也, 赤崎 卓, 藤島 八重, 阿部 功, 二宮 利治, 後藤 健一, 土橋 卓也, 北園 孝成

    日本高血圧学会総会プログラム・抄録集  2024.10  (NPO)日本高血圧学会

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  • 本邦における認知症コホート研究の最前線 脳の部位別灰白質萎縮が認知症発症に与える影響 久山町研究

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    老年精神医学雑誌  2022.11  (株)ワールドプランニング

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  • 本邦における認知症コホート研究の最前線 脳の部位別灰白質萎縮が認知症発症に与える影響 久山町研究

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    Dementia Japan  2022.10  (一社)日本認知症学会

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  • 日本人地域住民における角膜ヒステリシスと緑内障の関連 久山町研究

    藤原 康太, 上田 瑛美, 橋本 左和子, 中村 駿, 秦 淳, 中野 聡子, 村上 祐介, 久保田 敏昭, 吉冨 健志, 二宮 利治, 園田 康平

    日本緑内障学会抄録集  2022.9  日本緑内障学会

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  • 日本人地域住民における血清NT-proBNPの変粧と慢性腎臓病発症との関連 久山町研究

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    日本高血圧学会総会プログラム・抄録集  2023.9  (NPO)日本高血圧学会

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  • 日本人地域住民における血圧管理レベル別にみた心血管病発症率の時代的推移 久山町研究

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    日本高血圧学会総会プログラム・抄録集  2022.10  (NPO)日本高血圧学会

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  • 日本人地域住民における座位行動と糖代謝マーカーの経時変化および糖尿病発症の関連 久山町研究

    津田 晋, 本田 貴紀, 東岡 真由, 秦 淳, 中野 敏昭, 北園 孝成, 二宮 利治

    Journal of Epidemiology  2024.1  (一社)日本疫学会

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  • 日本人地域住民におけるMetabolically healthy obesityと心血管病発症の関連 久山町研究

    東岡 真由, 秦 淳, 平川 洋一郎, 坂田 智子, 本田 貴紀, 大澤 春彦, 二宮 利治

    日本循環器病予防学会誌  2022.5  (一社)日本循環器病予防学会

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  • 日本人一般集団における血圧の日間変動と慢性腎臓病発症リスク

    佐々木 峻也, 坂田 智子, 大石 絵美, 秦 淳, 坪井 伸夫, 北園 孝成, 横尾 隆, 二宮 利治

    日本高血圧学会総会プログラム・抄録集  2023.9  (NPO)日本高血圧学会

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  • 日本人一般集団における家庭血圧の日内変動と心房細動のリスク 久山町研究(Day-to-day Home Blood Pressure Variability and Risk of Atrial Fibrillation in a General Japanese Population: The Hisayama Study)

    前園 明寛, 坂田 智子, 秦 淳, 大石 絵美, 井手 友美, 北園 孝成, 筒井 裕之, 二宮 利治

    日本循環器学会学術集会抄録集  2023.3  (一社)日本循環器学会

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  • 従来の心血管疾患の危険因子と新たな危険因子 久山町研究(Conventional and Novel Risk Factors for Cardiovascular Disease: The Hisayama Study)

    秦 淳, Ninomiya Toshiharu

    日本循環器学会学術集会抄録集  2023.3  (一社)日本循環器学会

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  • 失感情症と慢性疼痛発症の関連及び抑うつ症状の影響 久山町研究

    柴田 舞欧, 二宮 利治, 平林 直樹, 森崎 悠紀子, 安野 広三, 吉田 大悟, 秦 淳, 須藤 信行, 細井 昌子

    日本慢性疼痛学会プログラム・抄録集  2025.2  日本慢性疼痛学会

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  • 地域高齢者の認知機能低下に伴う行動・心理症状と脳容積との関係 中山町研究

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    Dementia Japan  2024.10  (一社)日本認知症学会

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  • 地域高齢者における血清高感度CRPと認知症との関連 JPSC-AD研究

    立花 亜由美, 伊賀 淳一, 尾崎 智樹, 吉田 卓, 吉野 祐太, 清水 秀明, 森 崇明, 古田 芳彦, 柴田 舞欧, 小原 知之, 秦 淳, 瀧 靖之, 三上 達也, 前田 哲也, 小野 賢二郎, 三村 將, 中島 健二, 竹林 実, 二宮 利治, 上野 修一

    Dementia Japan  2024.10  (一社)日本認知症学会

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  • 地域高齢者における歯周組織状態と認知症発症の関連性 10年間のコホート研究

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    口腔衛生学会雑誌  2025.4  (一社)日本口腔衛生学会

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  • 地域高齢者における慢性疼痛重症度とADL障害発症との関連 久山町研究

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    Journal of Musculoskeletal Pain Research  2024.11  (一社)日本運動器疼痛学会

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  • 地域高齢者における交流頻度と脳萎縮の関連 JPSC-AD研究

    平林 直樹, 本田 貴紀, 秦 淳, 古田 芳彦, 柴田 舞欧, 小原 知之, 須藤 信行, 二宮 利治

    日本心身医学会総会ならびに学術講演会プログラム・抄録集  2022.6  日本心身医学会総会ならびに学術講演会事務局

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  • 地域高齢住民における領域別脳容積と慢性腰痛の関連 久山町研究

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    日本心療内科学会誌  2022.11  (NPO)日本心療内科学会

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  • 地域高齢住民における認知症有病率の時代的変化 久山町研究

    小原 知之, 二宮 利治

    Dementia Japan  2023.10  (一社)日本認知症学会

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  • 地域高齢住民における歯数とサルコペニア発症との関連 久山町研究

    友岡 祥子, 柏崎 晴彦, 二宮 利治

    日本老年歯科医学会総会・学術大会プログラム・抄録集  2024.6  (一社)日本老年歯科医学会

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  • 地域高齢住民における歯数とサルコペニア発症との関連 久山町研究

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    日本老年医学会雑誌  2023.10  (一社)日本老年医学会

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  • 地域高齢住民における大脳白質病変および全脳容積低下が認知症発症に及ぼす影響 久山町研究

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    精神神経学雑誌  2022.4  (公社)日本精神神経学会

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  • 地域高齢住民におけるサルコペニアと脳萎縮との関連 久山町研究

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    日本整形外科学会雑誌  2023.3  (公社)日本整形外科学会

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  • 地域住民剖検例における血清NT-proBNP値と腎組織所見との関連 久山町研究

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    日本腎臓学会誌  2022.5  (一社)日本腎臓学会

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  • 地域住民剖検例における皮質領域別の腎組織所見 久山町研究

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    日本腎臓学会誌  2022.5  (一社)日本腎臓学会

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  • 地域住民を対象とした生活習慣病の疫学研究 久山町研究 腎・尿管結石の調査成績も含めて

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    日本尿路結石症学会誌  2023.2  日本尿路結石症学会

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  • 地域住民を対象とした生活習慣病の疫学研究 久山町研究 腎・尿管結石の調査成績も含めて

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    日本尿路結石症学会誌  2022.7  日本尿路結石症学会

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  • 地域住民における高血圧の有病率・管理状況および心血管病発症リスクの時代的推移 久山町研究

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    日本高血圧学会総会プログラム・抄録集  2023.9  (NPO)日本高血圧学会

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  • 地域住民における角膜ヒステリシスと緑内障の関連 久山町研究

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    日本眼科学会雑誌  2023.3  (公財)日本眼科学会

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  • 地域住民における血清メチオニン代謝産物濃度と認知症発症および死亡リスクの関連 久山町研究

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    精神神経学雑誌  2022.4  (公社)日本精神神経学会

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  • 地域住民における社会的・情緒的孤独感は慢性疼痛と関連する 久山町研究

    柴田 舞欧, 細井 昌子, 秦 淳, 二宮 利治

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  • 地域住民における社会的・情緒的孤独感と慢性疼痛の関連 久山町研究

    柴田 舞欧, 平林 直樹, 細井 昌子, 安野 広三, 秦 淳, 須藤 信行, 二宮 利治

    日本未病学会学術総会抄録集  2023.12  (一社)日本未病学会

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  • 地域住民における皮膚カロテノイドレベルとメタボリックシンドロームの関連 久山町研究

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    日本栄養・食糧学会大会講演要旨集  2023.3  (公社)日本栄養・食糧学会

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  • 地域住民における心理社会的因子と慢性疾患の関係 久山町研究

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    日本心療内科学会誌  2022.11  (NPO)日本心療内科学会

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  • 地域住民における尿中神経伝達物質と抑うつ症状発症の関連 久山町研究

    柴田 舞欧, 平林 直樹, 細井 雅子, 中村 侑里, 秦 淳, 須藤 信行, 二宮 利治

    日本心療内科学会誌  2023.12  (NPO)日本心療内科学会

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  • 地域住民における動脈硬化性疾患の疫学研究 久山町研究

    二宮 利治

    臨床化学  2023.10  (一社)日本臨床化学会

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  • 地域住民における動脈硬化性疾患の疫学研究 久山町研究

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    日本動脈硬化学会総会プログラム・抄録集  2022.7  (一社)日本動脈硬化学会

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  • 地域住民における乳頭周囲脈絡膜厚と緑内障の関連:久山町研究

    藤原 康太, 上田 瑛美, 秦 淳, 橋本 左和子, 中村 駿, 村上 祐介, 久保田 敏昭, 吉冨 健志, 二宮 利治, 園田 康平

    日本緑内障学会抄録集  2024.9  日本緑内障学会

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  • 地域住民におけるサルコペニア肥満と心血管病発症の関連 久山町研究

    瀬戸山 優, 多治見 昂洋, 本田 貴紀, 秦 淳, 北園 孝成, 中島 康晴, 二宮 利治

    日本整形外科学会雑誌  2023.3  (公社)日本整形外科学会

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  • 地域住民において尿中神経伝達物質減少は抑うつ症状発症に関連する 久山町研究

    柴田 舞欧, 平林 直樹, 中村 侑里, 細井 昌子, 秦 淳, 須藤 信行, 二宮 利治

    日本未病学会学術総会抄録集  2024.10  (一社)日本未病学会

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  • 地域コホート研究からみた生活習慣・生活習慣病と脳画像との関連 久山町コホートからみた生活習慣病・生活習慣と脳画像との関連

    小原 知之, 二宮 利治

    Dementia Japan  2023.10  (一社)日本認知症学会

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  • 嗅覚低下と軽度認知障害および部位別脳萎縮の関連 久山町研究

    三野原 敏文, 小原 知之, 中澤 太郎, 平林 直樹, 秦 淳, 古田 芳彦, 三原 茜, 柴田 舞欧, 中尾 智博, 二宮 利治

    老年精神医学雑誌  2022.11  (株)ワールドプランニング

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  • 嗅覚低下と軽度認知障害および部位別脳萎縮の関連 久山町研究

    三野原 敏文, 小原 知之, 中澤 太郎, 平林 直樹, 秦 淳, 古田 芳彦, 三原 茜, 柴田 舞欧, 中尾 智博, 二宮 利治

    Dementia Japan  2022.10  (一社)日本認知症学会

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  • 唾液中の分泌型IgA濃度と口腔常在微生物叢の細菌構成の関係

    濱 栞音, 朝川 美加李, 影山 伸哉, 竹下 徹, 二宮 利治

    Journal of Oral Biosciences Supplement  2024.11  (一社)歯科基礎医学会

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  • 危険に曝される脳 日本人女性とスウェーデン人女性の社会経済および生活習慣による負担(Brain at risk: socioeconomic-lifestyle burden on Japanese and Swedish female)

    Liu Yingxu, Tatewaki Yasuko, Thyreau Benjamin, Zhang Ye, Boraxbekk Boraxbekk, Hidaka Yosuke, Kajitani Kajitani, Yuki Seiji, Takebayashi Minoru, Ninomiya Toshiharu, Taki Yasuyuki, Karalija Nina

    Dementia Japan  2023.10  (一社)日本認知症学会

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  • 動脈硬化性疾患予防ガイドライン2022と今後の展望 地域住民における動脈硬化性疾患発症のリスク予測モデルと「久山町スコア」の作成 久山町研究

    本田 貴紀, 陳 三妹, 秦 淳, 吉田 大悟, 平川 洋一郎, 古田 芳彦, 柴田 舞欧, 坂田 智子, 北園 孝成, 二宮 利治

    日本動脈硬化学会総会プログラム・抄録集  2022.7  (一社)日本動脈硬化学会

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  • 動脈硬化に関する疫学研究の日韓比較 一般住民における動脈硬化性疾患のリスク評価 久山町研究(Risk assessment of arteriosclerotic disease in a general population: the Hisayama Study)

    Ninomiya Toshiharu

    日本動脈硬化学会総会プログラム・抄録集  2024.6  (一社)日本動脈硬化学会

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  • 全国の一般地域住民における最近の循環器疾患発症率 NIPPON DATA2010

    門田 文, 大久保 孝義, 原田 亜紀子, 高嶋 直敬, 有馬 久富, 二宮 利治, 秦 淳, 寳澤 篤, 中村 幸志, 東山 綾, 大澤 正樹, 久松 隆史, 鳥居 さゆ希, 岡見 雪子, 近藤 慶子, 宮本 恵宏, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之

    Journal of Epidemiology  2024.1  (一社)日本疫学会

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  • 健診データを用いた臨床研究の実際

    二宮 利治

    総合健診  2022.1  (一社)日本総合健診医学会

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  • 健診データを用いた臨床研究の実際

    二宮 利治

    CAMPUS HEALTH  2023.3  (公社)全国大学保健管理協会

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  • 健診データを用いた臨床研究の実際

    二宮 利治

    全国大学保健管理研究集会プログラム・抄録集  2022.10  (公社)全国大学保健管理協会

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  • 令和の日本人の健康と日常を快適に過ごすための細胞-身体活性化法 地域住民における認知症コホート研究 筋力低下予防の重要性 久山町研究

    二宮 利治

    日本未病学会学術総会抄録集  2022.10  (一社)日本未病学会

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  • 中年期地域住民における要介護認定の危険因子の探索 福岡市地域包括ケア情報プラットフォームデータによる縦断的検討

    二宮 利治, 木村 安美, 本田 貴紀, 古田 芳彦, 吉田 大悟, 秦 淳

    総合健診  2022.1  (一社)日本総合健診医学会

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  • 一般住民におけるLATE-NCの頻度と病理学的特徴.久山町研究

    森 慎一郎, 本田 裕之, 濱崎 英臣, 小原 知之, 二宮 利治, 岩城 徹

    臨床神経学  2022.10  (一社)日本神経学会

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  • コホート研究から探る緑内障に関与する因子 地域一般住民における緑内障に関与する因子 久山町研究

    藤原 康太, 二宮 利治, 園田 康平

    日本眼科学会雑誌  2022.3  (公財)日本眼科学会

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  • コホート研究から健康長寿の鍵を紐解く 地域認知症コホート研究 久山町研究における最近の知見

    二宮 利治

    日本抗加齢医学会総会プログラム・抄録集  2024.5  (一社)日本抗加齢医学会

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  • アルツハイマー病発症予防に向けた新規バイオマーカー・治療法の開発 地域住民における認知症発症リスク予測モデルの開発 久山町研究

    二宮 利治

    老年精神医学雑誌  2022.11  (株)ワールドプランニング

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  • アルツハイマー病発症予防に向けた新規バイオマーカー・治療法の開発 地域住民における認知症発症リスク予測モデルの開発 久山町研究

    二宮 利治

    Dementia Japan  2022.10  (一社)日本認知症学会

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  • アルツハイマー型認知症の脳内におけるトランスサイレチンの発現様式の検討

    水野 裕理, 本田 裕之, 二宮 利治, 磯部 紀子, 村井 弘之

    Dementia Japan  2023.10  (一社)日本認知症学会

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  • わが国における認知症の疫学研究の最前線 脳萎縮および白質病変が認知症発症に及ぼす影響 久山町研究

    中澤 太郎, 小原 知之, 二宮 利治

    精神神経学雑誌  2023.6  (公社)日本精神神経学会

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  • わが国における糖尿病合併症に関するエビデンス 血清グリコアルブミン値と心血管病発症との関係 久山町研究

    二宮 利治

    糖尿病合併症  2023.7  (一社)日本糖尿病合併症学会

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  • わが国における糖尿病合併症に関するエビデンス 血清グリコアルブミン値と心血管病発症との関係 久山町研究

    二宮 利治

    糖尿病合併症  2022.9  (一社)日本糖尿病合併症学会

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  • わが国で進行中の疫学研究からみた認知症の発症リスク低減 地域高齢住民における認知症の実態とその危険因子 久山町研究

    小原 知之, 二宮 利治

    精神神経学雑誌  2022.4  (公社)日本精神神経学会

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  • つらい痛みを予防するには? みんなの痛みを心身医学的疫学研究からみる

    柴田 舞欧, 安野 広三, 二宮 利治, 細井 昌子

    日本慢性疼痛学会プログラム・抄録集  2023.2  日本慢性疼痛学会

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  • 「データベース研究の新展開」 地域疫学研究を基盤とした脳梗塞発症のリスク予測 久山町研究

    秦 淳, 二宮 利治

    脳循環代謝  2023.11  (一社)日本脳循環代謝学会

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  • PCBP2はALSにおいて変性神経細胞で発現低下し稀にスケイン様封入体で観察される(PCBP2 is downregulated in degenerating neurons and rarely observed in skein-like inclusions in ALS)

    Yoshimura Motoi, Honda Hiroyuki, Sasagasako Naokazu, Mori Shinichiro, Ishii Takashi, Ninomiya Toshiharu, Isobe Noriko, Iwaki Toru

    臨床神経学  2022.10  (一社)日本神経学会

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  • Mild parkinsonian signs症例における血液バイオマーカーの関連 海士町研究

    古和 久典, 深田 育代, 中野 俊也, 岸 真文, 和田 健二, 建部 陽嗣, 徳田 隆彦, 二宮 利治, 中島 健二

    神経治療学  2024.10  (一社)日本神経治療学会

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  • MCI(aMCI・naMCI)における健康関連QOLとそれに関連する臨床的特徴

    深田 育代, 古和 久典, 中野 俊也, 二宮 利治, 中島 健二

    老年精神医学雑誌  2022.11  (株)ワールドプランニング

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  • MCI(aMCI・naMCI)における健康関連QOLとそれに関連する臨床的特徴

    深田 育代, 古和 久典, 中野 俊也, 二宮 利治, 中島 健二

    Dementia Japan  2022.10  (一社)日本認知症学会

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  • COPD研究のcutting edge 日本人地域住民におけるpreserved ratio impaired spirometryが総死亡および認知症発症に及ぼす影響 久山町研究

    川床 健司, 鷲尾 康圭, 岡本 勇, 二宮 利治

    日本呼吸器学会誌  2024.3  (一社)日本呼吸器学会

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  • COPD 疫学 日本人地域住民におけるpreserved ratio impaired spirometryとその予後の検討 久山町研究(アンコール演題)

    鷲尾 康圭, 坂田 智子, 福山 聡, 本田 貴紀, 神尾 敬子, 柴田 舞欧, 秦 淳, 井上 博雅, 北園 孝成, 松元 幸一郎, 二宮 利治

    日本呼吸器学会誌  2023.3  (一社)日本呼吸器学会

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  • ARTAG形成の分布とリスク因子 久山町研究(Distributions and risk factors in ARTAG formation: The Hisayama study)

    八木田 薫, 小原 知之, 濱崎 英臣, 小山 祥子, 野口 英子, 秦 淳, 二宮 利治, 本田 裕之

    老年精神医学雑誌  2022.11  (株)ワールドプランニング

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  • ARTAG形成の分布とリスク因子 久山町研究(Distributions and risk factors in ARTAG formation: The Hisayama study)

    八木田 薫, 小原 知之, 濱崎 英臣, 小山 祥子, 野口 英子, 秦 淳, 二宮 利治, 本田 裕之

    Dementia Japan  2022.10  (一社)日本認知症学会

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  • 21世紀の冠動脈疾患の予防:リスクスコアや新たな検査・薬剤をどう使いこなすか? 日本人を対象とした動脈硬化性疾患の新しい発症リスク予測モデル;久山町研究

    秦 淳, 本田 貴紀, 陳 三妹, 二宮 利治, 川久保 裕美子

    日本心臓病学会学術集会抄録  2022.9  (一社)日本心臓病学会

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  • 1機会に測定した1回目と2回目の家庭血圧値の変化に影響する因子の検討 福岡高血圧コホート(FHC)研究

    寒水 康雄, 松村 潔, 大森 将, 坂田 智子, 大坪 俊夫, 冨永 光裕, 鍵山 俊太郎, 川崎 純也, 赤崎 卓, 藤島 八重, 阿部 功, 二宮 利治, 後藤 健一, 土橋 卓也, 北園 孝成

    日本高血圧学会総会プログラム・抄録集  2023.9  (NPO)日本高血圧学会

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MISC

  • Risk of stroke in kidney disease

    Ninomiya T

    Contrib Nephrol 179: 58-66, 2013   2013.5

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  • 特集:認知症の予防と進行抑制 -生活習慣を中心に- 1. 生活習慣病と認知症 1) 高血圧と認知症との関係および降圧薬による認知症の予防.

    二宮 利治, 清原 裕.

    Geriatric Medicine 48: 595-599, 2010.   2010.5

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  • 脳卒中の危険因子.

    二宮 利治, 清原 裕.

    medicina 46 1743-1746, 2009   2009.11

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  • 特集 血栓症をめぐるわが国の疫学研究. Ⅱ.心疾患 3.JALS(Japan Arteriosclerosis Longitudinal Study)[2]:一般住民における慢性腎臓病と血圧が心血管病発症に及ぼす影響(メタアナリシス).

    二宮 利治, 清原 裕.

    血栓と循環 17 65-67, 2009   2009.6

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  • 慢性腎臓病:診断と治療の進歩. 慢性腎臓病と各種疾患. 心血管疾患.

    二宮 利治, 清原 裕.

    日本内科学会雑誌 96: 887-893, 2007   2007.6

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  • Albuminuria and chronic kidney disease in association with the metabolic syndrome.

    Ninomiya T, Kiyohara Y.

    J Cardiometab Syndr 2: 104-107, 2007   2007.2

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  • 久山町研究からみた慢性腎臓病.

    二宮 利治, 清原 裕.

    綜合臨牀 55: 1248-1254, 2006   2006.4

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  • 久山町スタデイにおけるCKD.

    二宮 利治, 清原 裕.

    腎臓 29: 99-103, 2006   2006.2

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  • <インタビュー>100年元気を目指すアンチエイジング学.認知症の発症を遅らせるために今日からすべきこと.「日本の縮図」久山町研究が描く明るい未来【後編】.

    二宮利治

    日経Gooday 最新・信頼の健康・医療情報webサイト,   2025.2

  • 特集:孤立・孤独. 社会的孤立および孤独感が認知症リスクに及ぼす影響に関する疫学的知見.

    二宮利治

    BRAIN and NERVE   77   119 - 125   2025.2

  • 【孤立・孤独】社会的孤立および孤独感が認知症リスクに及ぼす影響に関する疫学的知見

    二宮 利治

    BRAIN and NERVE: 神経研究の進歩   77 ( 2 )   0119 - 0125   2025.2   ISSN:1881-6096

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    <文献概要>超高齢社会を迎えたわが国では,認知症者の増加を抑えることが喫緊の課題である。社会的孤立や孤独感は,認知症発症リスクを高める危険因子であることが国内外の疫学研究で示されている。社会的孤立による脳への刺激の減少や主観的なつながり不足による孤独感の状態が長期化すると,認知症の発症リスクが上昇することが報告されている。高齢者への社会的支援や孤独感の軽減が,認知症発症のリスク低減において重要であろう。

  • <インタビュー>100年元気を目指すアンチエイジング学.認知症はこの先減っていく?見えてきた「先延ばし」戦略.「日本の縮図」久山町研究が描く明るい未来【前編】.

    二宮利治

    日経Gooday 最新・信頼の健康・医療情報webサイト,   2025.1

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  • <座談会>認知症 Cross Talk.本邦における認知症の最新疫学・介入研究.

    古和久朋、櫻井 孝、二宮利治

    The Curator of Neurocognitive Disorders 2: 8-15, 2025   2   8 - 15   2025.1

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  • 【本邦における認知症の最新疫学・介入研究】地域疫学研究の成果からみた認知症リスク低減の可能性

    二宮 利治

    The Curator of Neurocognitive Disorders   2 ( 1 )   18 - 23   2025.1   ISSN:2759-5552

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  • 認知症CrossTalk 本邦における認知症の最新疫学・介入研究

    古和 久朋, 櫻井 孝, 二宮 利治

    The Curator of Neurocognitive Disorders   2 ( 1 )   8 - 15   2025.1   ISSN:2759-5552

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  • 一人暮らし、フリーランス認知症「2025問題」に向き合う(21) 認知症の将来推計が大幅低下?健康意識の高まりと生活習慣病コントロールに活路あり.

    二宮利治

    Wedge ONLINE 2024.8.2   2024.8

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  • 一人暮らし、フリーランス認知症「2025問題」に向き合う(23) 専門家に教わった「認知機能をキープするために今日から始められること」.

    二宮利治

    Wedge ONLINE 2024.8.2   2024.8

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  • サントリー生命科学研究所研究員と探る.脳の健康にいいことって?.

    二宮利治、得田研究員

    美感遊創   259   9 - 14   2024.7

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  • 地域認知症コホート研究の最近知見 久山町研究

    二宮 利治

    老年期認知症研究会誌   25 ( 2 )   18 - 19   2024.6

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  • 日本動脈硬化学会(JAS) 動脈硬化性疾患予防ガイドライン2022年版(Japan Atherosclerosis Society(JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2022)

    Okamura Tomonori, Tsukamoto Kazuhisa, Arai Hidenori, Fujioka Yoshio, Ishigaki Yasushi, Koba Shinji, Ohmura Hirotoshi, Shoji Tetsuo, Yokote Koutaro, Yoshida Hiroshi, Yoshida Masayuki, Deguchi Juno, Dobashi Kazushige, Fujiyoshi Akira, Hamaguchi Hirotoshi, Hara Masumi, Harada-Shiba Mariko, Hirata Takumi, Iida Mami, Ikeda Yoshiyuki, Ishibashi Shun, Kanda Hideyuki, Kihara Shinji, Kitagawa Kazuo, Kodama Satoru, Koseki Masahiro, Maezawa Yoshiro, Masuda Daisaku, Miida Takashi, Miyamoto Yoshihiro, Nishimura Rimei, Node Koichi, Noguchi Midori, Ohishi Mitsuru, Saito Isao, Sawada Shojiro, Sone Hirohito, Takemoto Minoru, Wakatsuki Akihiko, Yanai Hidekatsu, Fujihara Kazuya, Hasegawa Koji, Hiraishi Chika, Honda Takanori, Horiuchi Hisanori, Katsuyama Hisayuki, Kuwabara Akiko, Matsui Sadako, Matsuki Kota, Mianamino Tetsuo, Morishita Eriko, Nakao Yoko M., Natsuaki Masahiro, Nishikido Toshiyuki, Ohtake Akira, Okazaki Hiroaki, Sugiyama Daisuke, Tada Hayato, Taketani Yutaka, Tamori Yoshikazu, Tanaka Atsushi, Yamamoto Yukiyo, Yamashita Shizuya, Yamato Hiroshi, Yoshizumi Toru, Ando Koichi, Chiba Hiraku, Doi Takahito, Emori Hiroki, Fukushima Yoshifumi, Hayashi Aiko, Higashiyama Aya, Hirata Aya, Hirayama Satoshi, Inagaki Kyoko, Ishikawa Takahiro, Iso-o Naoyuki, Kanno Kotaro, Kataoka Yu, Kinoshita Daisuke, Kinuta Minako, Kohmo Kyoko, Koshizaka Masaya, Kubota Yoshimi, Makino Hisashi, Maruyama Koutatsu, Matsubara Masaki, Nakagawa-Tsutsui Wao, Nakai Yasuo, Nakamoto Mariko, Narumi-Hyakutake Aiko, Nishikawa Tetsuo, Nomura Akihiro, Oda Tomoyasu, Ogura Masatsune, Oohira Hideo, Ohminami Hirokazu, Okada Takeshi, Okada Hirofumi, Okajima Fumitaka, Okamoto Rie, Okazaki Sachiko, Omote Shizuko, Saiki Atsuhito, Sakamoto Kaori, Sata Mizuki, Sato Kayoko, Shiratori Yoshitaka, Shoji Mayumi, Suganuma Yuka, Suzuki Daisuke, Suzuki Harumitsu, Suzuki Nobuaki, Takahashi Hiroshi, Takahashi Yutaro, Takanashi Mikio, Takase Satoru, Takebe Noriko, Tamura Yukinori, Tanaka Kaki, Tanaka Katsunao, Tanaka Sarasa, Tanaka Yoshihiro, Terada Kousei, Teramoto Naoya, Tsukagoshi-Yamaguchi Ayano, Wakasa Hana, Yako Rie, Yamada Eri, Yamamoto Masashi, Yashiro Satoshi, Yokota Yuya, Yoshimura Yukihiro, Yan Zhang, Akishita Masahiro, Ako Junya, Bujo Hideaki, Emoto Masanori, Goto Shinya, Hanada Hiroyuki, Hosomi Naohisa, Hozawa Atsushi, Ikewaki Katsunori, Ishida Tatsurou, Kajinami Kouji, Kameyama Noriko, Kikuchi Toru, Kozaki Koichi, Kuwabara Kazuyo, Masuzaki Hiroaki, Matoba Tetsuya, Matoba Yuka, Miyata Masaaki, Ninomiya Toshiharu, Ogura Masatsune, Ohtsuki Toshiho, Ohya Yusuke, Okuda Nagako, Saitoh Shigeyuki, Shimano Hitoshi, Tomiyama Hirofumi, Toyoda Kazunori, Tsushita Kazuyo, Ueda Yukihiko, Umemoto Seiji, Yahagi Naoya, Yamagishi Kazumasa, Yamashita Tomoya, Daida Hiroyuki, Kinoshita Makoto, Yokode Masayuki, Japan Atherosclerosis Society

    Journal of Atherosclerosis and Thrombosis   31 ( 6 )   641 - 853   2024.6   ISSN:1340-3478

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  • -巻頭言- 臨床・疫学研究からみた認知症の発症リスク低減の可能性. Reviewed

    二宮利治

    きんむ医   2024.3

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  • 認知症発症のリスク低減における筋力・運動機能維持の重要性:久山町研究.

    二宮利治

    理学療法学 福岡   37   39 - 42   2024.3

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  • 3.全国の一般地域住民における最近の循環器疾患発症率:NIPPON DATA2010.

    門田 文、大久保孝義、原田亜紀子、高嶋直敬、有馬久富、二宮利治、秦 淳、寳澤 篤、中村幸志、東山 綾、大澤正樹、久松隆史、鳥居さゆ希、岡見雪子、近藤慶子、宮本恵宏、岡村智教、上島弘嗣、岡山 明、三浦克之

    厚生労働行政推進調査事業費補助金「国民代表集団のコホート研究によるウィズ・コロナ時代の健康格差・健康寿命の規定要因の解明および健康調査のオンライン化の検討:NIPPON DATA80/90/2010」令和5年度総括・分担研究報告書,   79 - 80   2024.3

  • 5.NIPPON DATA2010追跡・分析ワーキンググループ報告.

    大久保孝義、門田 文、原田亜紀子、有馬久富、高嶋直敬、中村幸志、二宮利治、秦 淳、寳澤 篤、宮本恵宏、大澤正樹、鳥居さゆ希、東山 綾、久松隆史、浅山 敬、大西浩文、櫻井 勝、平田 匠、宮澤伊都子、八谷 寛

    厚生労働行政推進調査事業費補助金「国民代表集団のコホート研究によるウィズ・コロナ時代の健康格差・健康寿命の規定要因の解明および健康調査のオンライン化の検討:NIPPON DATA80/90/2010」令和3年度~令和5年度総合研究報告書,   50 - 74   2024.3

  • 5.NIPPON DATA2010追跡・分析ワーキンググループ報告.

    大久保孝義、門田 文、原田亜紀子、有馬久富、高嶋直敬、中村幸志、二宮利治、秦 淳、寳澤 篤、宮本恵宏、大澤正樹、鳥居さゆ希、東山 綾、久松隆史、浅山 敬、大西浩文、櫻井 勝、平田 匠、宮澤伊都子、八谷 寛

    厚生労働行政推進調査事業費補助金「国民代表集団のコホート研究によるウィズ・コロナ時代の健康格差・健康寿命の規定要因の解明および健康調査のオンライン化の検討:NIPPON DATA80/90/2010」令和5年度総括・分担研究報告書,   38 - 61   2024.3

  • 認知症発症のリスク低減における筋力・運動機能維持の重要性 久山町研究

    二宮 利治

    理学療法福岡   ( 37 )   39 - 42   2024.3   ISSN:1342-1433

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  • 中高年者における座位時間と糖尿病および糖代謝指標の縦断的関連 久山町研究(Longitudinal association of sedentary time with diabetes mellitus and markers of glucose metabolism in middle-aged and older adults: The Hisayama Study)

    Tsuda Susumu, Honda Takanori, Higashioka Mayu, Hata Jun, Nakano Toshiaki, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Diabetes Investigation   15 ( 2 )   245 - 246   2024.2   ISSN:2040-1116

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  • 福岡市地域包括ケア情報プラットフォームのデータベースプロファイル(Database profile of the Fukuoka-City Information Platform for Community-based Integrated Care)

    Honda Takanori, Furuhashi Hiroko, Furuta Yoshihiko, Tomooka Shoko, Tajimi Takahiro, Nagasawa Fumi, Oishi Emi, Kimura Yasumi, Yoshida Daigo, Ninomiya Toshiharu

    Annals of Clinical Epidemiology   6 ( 1 )   5 - 11   2024.1

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  • 地域認知症コホート研究の最近知見:久山町研究.

    二宮 利治

    老年期認知症研究会誌   25   18 - 19   2024

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  • 私の論文から Multiple-region grey matter atrophy as a predictor for the development of dementia in a community: the Hisayama Study. Reviewed

    中澤太郎、小原知之、中尾智博、二宮利治

    九州神経精神医学   2023.12

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  • 【アルツハイマー病-研究と治療の最前線】予防・疫学 認知症の地域疫学研究の知見

    二宮 利治

    医学のあゆみ   287 ( 13 )   1002 - 1008   2023.12   ISSN:0039-2359

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    わが国では,超高齢社会を迎えて認知症患者の急増が医療・社会問題となっている.福岡県久山町で継続中の疫学調査の成績では,65歳以上の住民における認知症の粗有病率は,1985年の6.7%から2012年には17.9%と上昇した.一方,欧米諸国の疫学調査の成績では,認知症の有病率や罹患率が低下傾向にあるとの報告も散見される.また,最近の全世界における認知症者数の将来推計では,日本においては分析対象国のなかで最も増加率が低くとどまるとされている.さらに,久山町における2017年の認知症の有病率は15.6%であり,2012年以降さらなる上昇を認めなかった.この知見は,今後わが国においても認知症の有病率の増加傾向が鈍化することを示唆しているのかもしれない.認知症の発症リスクの低減を図るうえで,糖尿病や高血圧などの生活習慣病の予防や適切な管理に加え,禁煙,定期的な運動習慣,筋力維持,多様性のある食事などのさまざまな因子の包括的な対策を心がけることが重要であるといえよう.(著者抄録)

  • 特集 健康日本21(第三次)に向けて:ロコモ啓発の今とこれから. クリニカルクエスチョン②認知症発症予防における筋力・運動機能維持の重要性:久山町研究. Reviewed

    二宮利治

    Loco Cure   2023.11

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  • 【健康日本21(第三次)に向けて:ロコモ啓発の今とこれから】クリニカルクエスチョン 認知症発症予防における筋力・運動機能維持の重要性 久山町研究

    二宮 利治

    Loco Cure   9 ( 4 )   345 - 348   2023.11   ISSN:2189-4221

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  • 【脳卒中診療update-診断・治療の最新動向-】脳卒中疫学 最近の傾向

    秦 淳, 二宮 利治

    日本臨床   81 ( 9 )   1357 - 1362   2023.9   ISSN:0047-1852

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  • Epidemiology of stroke in a general Japanese population: the Hisayama Study. Reviewed

    Hata J, Ninomiya T

    Atheroscler Thromb   2023.7

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  • 合併症学会シンポジウム7 わが国における糖尿病合併症に関するエビデンス. 血清グリコアルブミン値と心血管病発症との関係:久山町研究. Reviewed

    二宮利治

    糖尿病合併症   2023.7

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  • 5.NIPPON DATA2010追跡・分析ワーキンググループ報告.

    大久保孝義、門田 文、原田亜紀子、有馬久富、高嶋直敬、中村幸志、二宮利治、秦 淳、寳澤 篤、宮本恵宏、大澤正樹、鳥居さゆ希、東山 綾、久松隆史、浅山 敬、大西浩文、櫻井 勝、平田 匠、宮澤伊都子、八谷 寛

    厚生労働行政推進調査事業費補助金循環器疾患・糖尿病等生活習慣病対策総合研究事業「国民代表集団のコホート研究によるウィズ・コロナ時代の健康格差・健康寿命の規定要因の解明および健康調査のオンライン化の検討:NIPPON DATA80/90/2010」令和4年度総括・分担研究報告書,   2023.7

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  • 日本人一般集団における脳卒中の疫学 久山町研究(Epidemiology of Stroke in a General Japanese Population: The Hisayama Study)

    Hata Jun, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   30 ( 7 )   710 - 719   2023.7   ISSN:1340-3478

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  • 腎臓病患者は動脈硬化が深刻で心血管病の発症リスクが三倍と大学の研究で判明.

    二宮利治

    健康365   2023.6

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  • 【認知症予防を考慮した糖尿病の治療】臨床・疫学 糖尿病と認知症の疫学 久山町研究

    三野原 敏文, 小原 知之, 二宮 利治

    月刊糖尿病   15 ( 3 )   6 - 12   2023.5

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    国内外の前向きコホート研究の成績から,糖尿病は認知症発症の危険因子であることが示唆される.福岡県久山町で継続中の疫学調査の成績を用いて両者の関係を検討した結果,糖尿病は認知症,とくにアルツハイマー型認知症発症の有意な危険因子だった.血糖レベル別の検討では,空腹時血糖値と認知症発症の関連は認められなかったが,糖負荷後2時間血糖値の上昇と認知症発症の間に有意な正の関連が認められた.また,剖検脳を用いた検討では,生前の糖尿病関連因子(糖負荷後2時間血糖値や空腹時インスリン値など)の上昇は老人斑沈着と有意に関連した.さらに,頭部MRIを用いた脳画像研究では,糖負荷後2時間血糖値の上昇と糖尿病の罹病期間の延長が海馬や側頭葉などの認知症に関わる脳部位の容積低下と有意に関連していた.認知症の社会的負担を軽減するために,糖尿病の予防とその適切な管理が重要と考えられる.(著者抄録)

  • 特集:糖尿病と認知症. Ⅰ-1.糖尿病と認知症の疫学:久山町研究. Reviewed

    三野原敏文、小原知之、二宮利治

    月刊糖尿病   2023.3

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  • ビジョナリーの声を聴け. 世界が注目する「ひさやま方式」生活習慣病から守る独自の調査と健康管理とは. Reviewed

    二宮利治

    老人ホーム検索サイトみんなの介護 webサイト   2023.3

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  • 2023 年改訂版 冠動脈疾患の一次予防に関する診療ガイドライン

    日本循環器学会(藤吉 朗、香坂 俊、小倉正恒、・・・、秦 淳、・・・、南野 徹)

    2021‒2022年度活動2023年改訂版 冠動脈疾患の一次予防に関する診療ガイドライン JCS 2023 Guideline on the Primary Prevention of Coronary Artery Disease, 2023.3   2023.3

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  • 生涯にわたる循環器疾患の個人リスクおよび集団リスクの評価ツールの開発及び臨床応用のための研究(20FA1002).

    村上義孝、岡村智教、二宮利治、大久保孝義、村木 功、磯 博康、玉腰暁子、小久保喜弘、宮本恵宏、三浦克之、大西浩文、辻 一郎、櫻井 勝、立川佳美、山田美智子、丹野高三、坂田清美、木山昌彦、石川鎮清、八谷 寛、中山健夫

    厚生労働科学研究費補助金循環器疾患・糖尿病等生活習慣病対策総合研究事業「生涯にわたる循環器疾患の個人リスクおよび集団リスクの評価ツールの開発及び臨床応用のための研究」令和2年度~令和4年度総合研究報告書   2023.3

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  • 個人のリスク因子変動を考慮した、循環器疾患等の発症危険度を予測するリスクエンジン開発.

    村上義孝、大久保孝義、三浦克之、丹野高三、坂田清美、石川鎮清、岡村智教、二宮利治、村木 功、磯 博康、大西浩文、櫻井 勝、立川佳美、山田美智子、八谷 寛、玉腰暁子、小久保喜弘、宮本恵宏、辻 一郎、木山昌彦、中山健夫、入江ふじこ、西連地利己、鈴木智子、竹内由則、大庭真梨

    厚生労働科学研究費補助金循環器疾患・糖尿病等生活習慣病対策総合研究事業「生涯にわたる循環器疾患の個人リスクおよび集団リスクの評価ツールの開発及び臨床応用のための研究」令和2年度~令和4年度総合研究報告書,   2023.3

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  • 集団レベルのリスク因子情報の利活用による、地域における中長期的予測(10年以上)の可能性の検討.

    村上義孝、大久保孝義、三浦克之、丹野高三、坂田清美、石川鎮清、岡村智教、二宮利治、村木 功、磯 博康、大西浩文、櫻井 勝、立川佳美、山田美智子、八谷 寛、玉腰暁子、小久保喜弘、宮本恵宏、辻 一郎、木山昌彦、中山健夫、入江ふじこ、西連地利己、鈴木智子、竹内由則、大庭真梨

    厚生労働科学研究費補助金循環器疾患・糖尿病等生活習慣病対策総合研究事業「生涯にわたる循環器疾患の個人リスクおよび集団リスクの評価ツールの開発及び臨床応用のための研究」令和2年度~令和4年度総合研究報告書,   2023.3

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  • 4. 久山町研究.

    二宮利治

    厚生労働科学研究費補助金循環器疾患・糖尿病等生活習慣病対策総合研究事業「生涯にわたる循環器疾患の個人リスクおよび集団リスクの評価ツールの開発及び臨床応用のための研究」令和2年度~令和4年度総合研究報告書,   2023.3

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  • 第29回日本未病学会学術総会 ■シンポジウム4「令和の日本人の健康と日常を快適に過ごすための細胞-身体活性化法」 地域住民における認知症コホート研究~筋力低下予防の重要性~:久山町研究. Reviewed

    二宮利治

    日本未病学会雑誌   2023.3

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  • 「令和の日本人の健康と日常を快適に過ごすための細胞-身体活性化法」 地域住民における認知症コホート研究 筋力低下予防の重要性 久山町研究

    二宮 利治

    日本未病学会雑誌   29 ( 1 )   40 - 45   2023.3   ISSN:2435-8584

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  • 特集Ⅰ:認知症の病態・診断・治療. 地域住民を対象とした認知症疫学研究:久山町研究. Reviewed

    二宮利治

    脳神経内科   2023.2

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  • トピックスⅡ. 疫学研究から探る動脈硬化性疾患リスクとは?~動脈硬化性疾患をエンドポイントとした久山町研究のスコアについて~. Reviewed

    二宮利治

    日本内科学会雑誌   2023.2

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  • 【動脈硬化Update】疫学研究から探る動脈硬化性疾患リスクとは? 動脈硬化性疾患をエンドポイントとした久山町研究のスコアについて

    二宮 利治

    日本内科学会雑誌   112 ( 2 )   165 - 172   2023.2   ISSN:0021-5384

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  • 特定健診における動脈硬化性疾患発症リスク予測モデルの評価可能性 大規模健診・医療レセプトデータベースを用いた検討

    本田 貴紀, 陳 三妹, 石田 有紀, 木村 安美, 吉田 大悟, 二宮 利治

    健康支援   25 ( 1 )   98 - 98   2023.2   ISSN:1345-0174 eISSN:2758-3449

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  • 【認知症の病態・診断・治療】地域住民を対象とした認知症疫学研究 久山町研究

    二宮 利治

    脳神経内科   98 ( 2 )   227 - 233   2023.2   ISSN:2434-3285

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  • 特集:認知症の包括的なリスク低減に向けて. 1.国内外の疫学研究の成果からみた認知症の発症リスク低減の可能性. Reviewed

    二宮利治

    Prog. Med.   2023.1

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  • 私の研究. 久山町研究. Reviewed

    小原知之、二宮利治

    日本生物学的精神医学会誌   2023.1

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  • 【認知症の包括的なリスク低減に向けて】国内外の疫学研究の成果からみた認知症の発症リスク低減の可能性

    二宮 利治

    Progress in Medicine   43 ( 1 )   11 - 17   2023.1   ISSN:0287-3648

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  • Erratum: MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer's Disease (Oxidative Medicine and Cellular Longevity (2021) 2021 (8635088) DOI: 10.1155/2023/8635088)

    Mizuno Y., Abolhassani N., Mazzei G., Sakumi K., Saito T., Saido T.C., Ninomiya T., Iwaki T., Yamasaki R., Kira J.I., Nakabeppu Y.

    Oxidative Medicine and Cellular Longevity   2023   9794081   2023   ISSN:19420900

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    In the article titled "MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer's Disease,"[1] the authors identified an error in the legend of Figure 8. The article should therefore be corrected as follows: "Scale bar = 100 μm"should be corrected to "Scale bar = 20 μm."The corrected legend is shown in the following: Figure 8: MUTYH deficiency suppressed the morphological alteration of microglia in the AppNL-G-F/NL-G-F brain. (a) Immunofluorescent micrograph of hippocampal microglia stained for Iba-1 (green) in six-month-old female wild-type (Wt), AppNL-G-F/NL-G-F (NL-G-F), and AppNL-G-F/NL-G-F.Mutyh-/- (NL-G-F.Mutyh) mice. Nuclei were counterstained with DAPI (blue). Scale bar = 20μm. (b) Three-dimensional reconstruction of microglia surrounding Aβ plaque in the sixmonth- old female hippocampus. Scale bar = 20 μm.

    DOI: 10.1155/2023/9794081

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  • Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries (Nature, (2022), 611, 7934, (115-123), 10.1038/s41586-022-05165-3)

    Mishra A., Malik R., Hachiya T., Jürgenson T., Namba S., Posner D.C., Kamanu F.K., Koido M., Le Grand Q., Shi M., He Y., Georgakis M.K., Caro I., Krebs K., Liaw Y.C., Vaura F.C., Lin K., Winsvold B.S., Srinivasasainagendra V., Parodi L., Bae H.J., Chauhan G., Chong M.R., Tomppo L., Akinyemi R., Roshchupkin G.V., Habib N., Jee Y.H., Thomassen J.Q., Abedi V., Cárcel-Márquez J., Nygaard M., Leonard H.L., Yang C., Yonova-Doing E., Knol M.J., Lewis A.J., Judy R.L., Ago T., Amouyel P., Armstrong N.D., Bakker M.K., Bartz T.M., Bennett D.A., Bis J.C., Bordes C., Børte S., Cain A., Ridker P.M., Cho K., Chen Z., Cruchaga C., Cole J.W., de Jager P.L., de Cid R., Endres M., Ferreira L.E., Geerlings M.I., Gasca N.C., Gudnason V., Hata J., He J., Heath A.K., Ho Y.L., Havulinna A.S., Hopewell J.C., Hyacinth H.I., Inouye M., Jacob M.A., Jeon C.E., Jern C., Kamouchi M., Keene K.L., Kitazono T., Kittner S.J., Konuma T., Kumar A., Lacaze P., Launer L.J., Lee K.J., Lepik K., Li J., Li L., Manichaikul A., Markus H.S., Marston N.A., Meitinger T., Mitchell B.D., Montellano F.A., Morisaki T., Mosley T.H., Nalls M.A., Nordestgaard B.G., O’Donnell M.J., Okada Y., Onland-Moret N.C., Ovbiagele B., Peters A., Psaty B.M., Rich S.S.

    Nature   612 ( 7938 )   E7   2022.12   ISSN:00280836

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    In the version of this article initially published, the name of the PRECISE4Q Consortium was misspelled as “PRECISEQ” and has now been amended in the HTML and PDF versions of the article. Further, data in the first column of Supplementary Table 55 were mistakenly shifted and have been corrected in the file accompanying the HTML version of the article.

    DOI: 10.1038/s41586-022-05492-5

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  • 第6回「歴史のうねり」セミナーより.講演2 久山町研究-58年目を迎えて-. Reviewed

    二宮利治

    學士鍋 205: 25, 2022   2022.12

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  • 【精神医学を基礎づける 疫学研究と臨床研究】疫学研究:精神疾患の実態と機序を解明する観察研究 地域住民を対象とした認知症疫学研究 久山町研究

    二宮 利治

    精神医学の基盤   6 ( 1 )   058 - 069   2022.12   ISSN:2188-9546

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    超高齢社会を迎えたわが国では,認知症患者の急増が医療・社会問題となっている。福岡県久山町で継続中の疫学調査(久山町研究)の成績を用いて,地域高齢住民における認知症有病率の時代的変化を検討したところ,アルツハイマー型認知症の粗有病率は1985年の1.2%から2012年の12.2%まで時代とともに有意に上昇した。一方,血管性認知症の有病率に明らかな時代的変化はなかった。認知症の危険因子を探索した結果,高血圧,糖尿病,喫煙習慣は認知症の有意な危険因子であった。一方,豆腐,野菜,牛乳を中心とした食習慣や定期的な運動習慣を有する者は認知症の発症リスクが低かった。また,睡眠時間や孤独感も認知症発症に関与していた。さらに,我々は長期追跡調査の成績を用いて,認知症発症予測のリスクスコアを作成した。認知症の発症リスク低減には認知症の危険因子の発症予防とその適切な管理が重要と考えられる。(著者抄録)

  • 特集/治せる認知症・認知症様状態を見逃さないために. 疫学研究の成果からみた認知症リスク低減の可能性. Reviewed

    二宮利治

    臨牀と研究   2022.11

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  • 【治せる認知症・認知症様状態を見逃さないために】疫学研究の成果からみた認知症リスク低減の可能性

    二宮 利治

    臨牀と研究   99 ( 11 )   1293 - 1298   2022.11   ISSN:0021-4965

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  • 地域高齢住民における領域別脳容積と慢性腰痛の関連 久山町研究

    柴田 舞欧, 浅田 雅子, 平林 直樹, 小原 知之, 古田 芳彦, 中澤 太郎, 本田 貴紀, 秦 淳, 細井 昌子, 二宮 利治, 須藤 信行

    日本心療内科学会誌   26 ( 別冊 )   126 - 126   2022.11   ISSN:1342-9558

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  • 嗅覚低下と軽度認知障害および部位別脳萎縮の関連 久山町研究

    三野原 敏文, 小原 知之, 中澤 太郎, 平林 直樹, 秦 淳, 古田 芳彦, 三原 茜, 柴田 舞欧, 中尾 智博, 二宮 利治

    老年精神医学雑誌   33 ( 増刊II )   270 - 270   2022.11   ISSN:0915-6305

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  • 特集:認知症施策 up to date. 地域疫学研究の成果から見た認知症リスク低減の可能性. Reviewed

    二宮利治

    公衆衛生   2022.10

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  • 特集:冠動脈疾患の一次予防 update. 冠動脈疾患の疫学と危険因子. Reviewed

    秦 淳、二宮利治

    環器内科   2022.10

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  • 【わが国における大規模コホート疫学研究について】久山町研究における認知症の疫学研究

    小原 知之, 二宮 利治

    精神科   41 ( 4 )   543 - 552   2022.10   ISSN:1347-4790

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  • 嗅覚低下と軽度認知障害および部位別脳萎縮の関連 久山町研究

    三野原 敏文, 小原 知之, 中澤 太郎, 平林 直樹, 秦 淳, 古田 芳彦, 三原 茜, 柴田 舞欧, 中尾 智博, 二宮 利治

    Dementia Japan   36 ( 4 )   763 - 763   2022.10   ISSN:1342-646X

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  • 【認知症施策up to date】地域疫学研究の成果から見た認知症リスク低減の可能性 久山町研究

    二宮 利治

    公衆衛生   86 ( 10 )   816 - 824   2022.10   ISSN:0368-5187

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    <文献概要>ポイント ◆久山町研究の成績では、高血圧、糖尿病などの生活習慣病や喫煙、食事、運動などのライフスタイルが認知症発症に関係していた。◆久山町研究の追跡調査の成果を基に、認知症発症予測のリスクスコアを作成した。◆認知症の発症リスク低減には、さまざまな危険因子に対する包括的な管理が重要であることが示唆される。

  • 【冠動脈疾患の一次予防update】冠動脈疾患の疫学と危険因子

    秦 淳, 二宮 利治

    循環器内科   92 ( 4 )   359 - 365   2022.10   ISSN:1884-2909

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  • 21世紀の冠動脈疾患の予防:リスクスコアや新たな検査・薬剤をどう使いこなすか? 日本人を対象とした動脈硬化性疾患の新しい発症リスク予測モデル;久山町研究

    秦 淳, 本田 貴紀, 陳 三妹, 二宮 利治, 川久保 裕美子

    日本心臓病学会学術集会抄録   70回   S11 - 1   2022.9

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  • 日本人地域住民における角膜ヒステリシスと緑内障の関連 久山町研究

    藤原 康太, 上田 瑛美, 橋本 左和子, 中村 駿, 秦 淳, 中野 聡子, 村上 祐介, 久保田 敏昭, 吉冨 健志, 二宮 利治, 園田 康平

    日本緑内障学会抄録集   33回   144 - 144   2022.9

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  • 特集:Current antihypertensive treatm防. Seminar 5.疫学データから考える認知症発症のリスク低減の可能性. Reviewed

    三原 茜、小原知之、二宮利治

    Geriat. Med   2022.7

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  • A SPECIAL EDITION  1⃣ 久山町における健診事業と地域認知症疫学研究. Reviewed

    二宮利治

    BIO Clinica   2022.7

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  • 【検診・人間ドックでここまで出来る】久山町における健診事業と地域認知症疫学研究

    二宮 利治

    BIO Clinica   37 ( 7 )   605 - 609   2022.7   ISSN:0919-8237

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    糟屋郡久山町では、40歳以上の住民を対象とした心血管病、生活習慣病の疫学調査(久山町研究)を1961年から長年継続している。久山町では、40歳以上の全住民を対象とした健診を実施することにより、住民の健康状態の実態把握に努めるとともに、自治体・大学・開業医が連携して「ひさやま方式」とよばれる住民の健康管理を継続している。本研究の研究テーマは、生活習慣病や心血管病のみならず認知症等の幅広い分野に研究テーマが広がっている。本稿では久山町における健診事業と地域住民を対象とした認知症疫学研究の成果を紹介する。(著者抄録)

  • 動脈硬化性疾患予防ガイドライン2022と今後の展望 地域住民における動脈硬化性疾患発症のリスク予測モデルと「久山町スコア」の作成 久山町研究

    本田 貴紀, 陳 三妹, 秦 淳, 吉田 大悟, 平川 洋一郎, 古田 芳彦, 柴田 舞欧, 坂田 智子, 北園 孝成, 二宮 利治

    日本動脈硬化学会総会プログラム・抄録集   54回   137 - 137   2022.7   ISSN:1347-7099

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  • 【認知症の共生と予防】疫学データから考える認知症発症のリスク低減の可能性

    三原 茜, 小原 知之, 二宮 利治

    Geriatric Medicine   60 ( 7 )   609 - 613   2022.7   ISSN:0387-1088

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    認知症の発症リスクを低減し、その社会的負担を軽減することは喫緊の課題である。生活習慣病や生活習慣と認知症の関係を検討した国内外の追跡研究の成績によると、高血圧(特に中年期)、糖尿病、喫煙習慣は認知症発症の有意な危険因子であった。一方、運動習慣や多様性に富む食習慣を有する人では、認知症の発症リスクが有意に低かった。これらの疫学データの知見より、認知症の発症リスクを低減する上で、禁煙、定期的な運動、多様性に富む食習慣などの健康的な生活習慣を心掛けるとともに、高血圧や糖尿病などの生活習慣病の予防とその適切な管理を行うことが重要であると考えられる。(著者抄録)

  • 特集:予防医学からみた腎疾患診療.【CKDの発症・進展と合併症のリスクとされるエビデンス】 肥満. 肥満と腎障害の疫学研究. Reviewed

    佐々木峻也、二宮利治

    腎と透析   2022.5

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  • 久山町研究 血清GA値と心血管疾患リスクが関連. Reviewed

    二宮利治

    Medical Tribune   2022.5

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  • 【予防医学からみた腎疾患診療】CKDの発症・進展と合併症のリスクとされるエビデンス 肥満 肥満と腎障害の疫学研究

    佐々木 峻也, 二宮 利治

    腎と透析   92 ( 5 )   833 - 837   2022.5   ISSN:0385-2156

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  • 地域住民における血清メチオニン代謝産物濃度と認知症発症および死亡リスクの関連 久山町研究

    三原 茜, 小原 知之, 秦 淳, 陳 三妹, 本田 貴紀, Tamrakar Sonam, 伊佐 亜希子, 王 冬梅, 清水 邦義, 片倉 喜範, 中尾 智博, 北園 孝成, 二宮 利治

    精神神経学雑誌   124 ( 4付録 )   S - 368   2022.4   ISSN:0033-2658

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  • 地域高齢住民における大脳白質病変および全脳容積低下が認知症発症に及ぼす影響 久山町研究

    中澤 太郎, 小原 知之, 平林 直樹, 古田 芳彦, 秦 淳, 柴田 舞欧, 本田 貴紀, 北園 孝成, 中尾 智博, 二宮 利治

    精神神経学雑誌   124 ( 4付録 )   S - 367   2022.4   ISSN:0033-2658

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  • 5.NIPPON DATA2010追跡・分析ワーキンググループ報告. Reviewed

    大久保孝義、門田 文、原田亜紀子、有馬久富、高嶋直敬、中村幸志、二宮利治、秦 淳、寳澤 篤、宮本恵宏、大澤正樹、鳥居さゆ希、東山 綾、久松隆史、浅山 敬、大西浩文、櫻井 勝、平田 匠、宮澤伊都子、八谷 寛

    厚生労働行政推進調査事業費補助金循環器疾患・糖尿病等生活習慣病対策総合研究事業「国民代表集団のコホート研究によるウィズ・コロナ時代の健康格差・健康寿命の規定要因の解明および健康調査のオンライン化の検討:NIPPON DATA80/90/2010」令和3年度総括・分担研究報告書,   2022.3

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  • 特集:認知症への理解と対応. 10年後の認知症発症リスクを予測するツールを開発――久山町研究. Reviewed

    二宮利治

    へるすあっぷ21   2022.3

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  • 総説(循環器病予防総説シリーズ31:要因編16) 慢性腎臓病と心血管病の関係. Reviewed

    二宮利治

    日本循環器病予防学会誌   2022.3

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  • 循環器病予防総説(シリーズ31) 要因編 慢性腎臓病と心血管病の関係

    二宮 利治

    日本循環器病予防学会誌   57 ( 1 )   20 - 34   2022.3   ISSN:1346-6267

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    国内外の地域住民を対象とした疫学調査の成績から、慢性腎臓病(CKD)は心血管病の有意な危険因子であるのみならず、冠状動脈硬化、左室肥大や認知症とも関連することが明らかになった。CKD患者は時代とともに増加傾向にあり、その増加を予防する上で、より徹底した高血圧管理と禁煙を推奨する必要がある。代謝性疾患の是正とともに、CKD患者における様々な合併症発症の予防対策をいかに行うかが今後の課題である。

  • 特集Ⅱ.わが国における大規模コホート疫学研究について. 久山町研究における認知症の疫学研究. Reviewed

    小原知之、二宮利治

    精神科   2022.2

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  • Preventive medicine, 60 years in the making. Reviewed

    Toshiharu Ninomiya

    KYUSHU UNIVERSITY CONNECT:   2022.2

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  • ‹講演録›地域住民における認知症コホート研究:久山町研究.第57回JA共済医学研究会.令和4年7月16日講演. Reviewed

    二宮利治

    共済エグザミナー通信   2022.2

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  • Ⅱ.疫学 久山町研究. Reviewed

    中西泰之、秦 淳、二宮利治

    日本臨牀 80 増刊号   2022.1

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  • 新春対談

    西村 勝、二宮利治

    広報ひさやま   2022.1

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  • 講演:地域住民における認知症コホート研究:久山町研究. Reviewed

    二宮利治

    医療と社会   2022.1

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  • 【最新臨床脳卒中学(第2版)上-最新の診断と治療-】疫学 久山町研究

    中西 泰之, 秦 淳, 二宮 利治

    日本臨床   80 ( 増刊1 最新臨床脳卒中学(上) )   47 - 52   2022.1   ISSN:0047-1852

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  • 認知症予防の最前線-認知症の一次、二次、三次予防の重要性- 地域住民における認知症コホート研究 久山町研究

    二宮 利治

    医療と社会   31 ( 4 )   495 - 507   2022.1   ISSN:0916-9202

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  • 活動的な通勤および通勤形態と糖尿病発症リスクの関連 久山町研究

    本田 貴紀, 平川 洋一郎, 秦 淳, 陳 三妹, 柴田 舞欧, 坂田 智子, 古田 芳彦, 東岡 真由, 大石 絵美, 北園 孝成, 二宮 利治

    Journal of Epidemiology   32 ( Suppl.1 )   136 - 136   2022.1   ISSN:0917-5040 eISSN:1349-9092

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  • 地域住民における認知症コホート研究 久山町研究

    二宮 利治

    共済エグザミナー通信   ( 51 )   1 - 17   2022

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  • 特集:脳卒中診療最前線. 脳卒中の疫学. Reviewed

    秦 淳、二宮利治

    臨牀と研究   2021.12

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  • 話題:久山町研究における認知症疫学研究. Reviewed

    二宮利治

    老年内科   2021.11

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  • 虚血性心疾患予防. sdLDL-Cを考慮すべし. Reviewed

    二宮利治

    Medical Tribune   2021.11

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  • ようこそ!わが研究室へ 53. 九州大学大学院医学研究院衛生・公衆衛生学分野. Reviewed

    二宮利治

    公衆衛生情報   2021.10

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  • 特集:生活習慣病. 地域住民における生活習慣病の疫学研究:久山町研究. Reviewed

    二宮利治

    臨牀と研究   2021.10

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  • 日本人の動脈硬化性疾患の変遷:久山町研究. Reviewed

    二宮利治

    Medical View Point,   2021.10

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  • 話題:久山町研究における認知症疫学研究. Reviewed

    二宮利治

    老年内科   2021.10

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  • 生活習慣病と認知症:久山町研究. Reviewed

    小原知之、二宮利治

    老年期認知症研究会誌   2021.8

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  • ふだんの運動と食事がポイント!認知症・生活習慣病予防クイズ.認知症と生活習慣病はつながっている!. Reviewed

    二宮利治

    たんぱく通信   2021.8

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  • 各論【循環器疾患】脳梗塞のゲノム疫学研究. Reviewed

    秦 淳、二宮利治

    医学のあゆみ   2021.7

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  • 九州大学研究室探訪! 久山町と共に歩み60年-未来の健康につなぐ-. Reviewed

    二宮利治

    九大広報   2021.7

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  • 特集:ロコモティブシンドロームの現況. Ⅳ.住民コホートによる評価. 1.久山町研究. Reviewed

    中村公隆、吉田大悟、二宮利治

    臨床雑誌整形外科   2021.5

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  • Psychiatric Lecture 疫学.睡眠と認知症の疫学. Reviewed

    小原知之、二宮利治

    精神科臨床Legato   2021.4

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  • 【アルツハイマー病における血管性危険因子】アルツハイマー型認知症の血管性危険因子:久山町研究. Reviewed

    小原知之、二宮利治

    Dementia Japan   2021.4

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  • 働き盛りの今から対策を. 生活習慣改善で認知症予防. Reviewed

    ‹監修›二宮利治

    けんぽフォトニュース   2021.3

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  • 命と思いの重さを噛みしめて. Reviewed

    二宮利治

    福博かわらばん   2021.3

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  • 第124回日本眼科学会総会特別講演Ⅰ 緑内障の治療戦略:臨床と薬理学. Reviewed

    吉富健志、伊東裕之、石川 均、二宮利治、山地一禎、石川 誠、澤田 有、藤原康太、藤原聡之、渡部広史、阿部早苗、太田祐介、神 大介、早川真弘、鍋島隆司、齊藤裕輔、西山俊吾、伊藤翔平、董 雅儒、松井孝子、新家 眞、岩瀬愛子

    日本眼科学会雑誌   2021.3

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  • 特集:腎領域疫学研究の進歩. 慢性腎臓病の地域疫学研究:久山町研究. Reviewed

    二宮利治

    日腎会誌   2021.2

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  • 特集:バイオバンクの医学研究への貢献. 1.脳梗塞のゲノム疫学:久山町研究. Reviewed

    秦 淳、二宮利治

    Precision Medicine   2021.2

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  • 特集:糖尿病診療の最前線. 糖尿病の疫学. Reviewed

    平川洋一郎、二宮利治

    臨牀と研究   2021.1

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  • 特集:生活習慣病と認知症コホート研究. 総論.生活習慣病と認知症:認知症コホート研究の役割. Reviewed

    二宮利治

    Medical Sciene Digest   2020.12

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  • 特集:わが国の臨床研究-最新の成果と将来展望. ‹疫学研究›久山町研究. Reviewed

    二宮利治

    循環器内科   2020.10

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  • 【認知症施策-最近の動向-】進行を少しでも遅らせ、穏やかに生きる手助けをする(予防) 健康長寿社会の実現を目指した大規模認知症コホート研究. Reviewed

    二宮利治

    Geriatric Medicine   2020.6

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    Repository Public URL: https://hdl.handle.net/2324/7172561

  • Ⅷ. 日本における高血圧の疫学と観察研究の最新知見.  日本における観察研究と高血圧の疫学.  久山町研究. Reviewed

    大石絵美, 二宮利治

    日本臨牀 78: 431-436, 2020   2020.6

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  • ‹講演2›コホート研究からみた認知症予防. Reviewed

    二宮利治

    超高齢社会を見据えて、今から始める予防策. 第2回 認知症と糖尿病・メタボ: 25-36, 2020   2020.3

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  • 血清 small dense LDL コレステロール値と虚血性心疾患発症の関係:久山町研究. Reviewed

    二宮利治, 東岡真由, 坂田智子

    臨牀と研究 97: 81-84, 2020   2020.3

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  • ‹パネルディスカッション›認知症予防を考える. Reviewed

    寺本民生, 羽生春夫, 二宮利治, 島田裕之

    超高齢社会を見据えて、今から始める予防策. 第2回 認知症と糖尿病・メタボ   2020.3

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  • 血清 small dense LDL コレステロール値と虚血性心疾患発症の関係:久山町研究. Reviewed

    二宮利治、東岡真由、坂田智子

    臨牀と研究 97: 81-84, 2020   2020.3

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  • 特集:1.糖尿病代謝と認知症.  地域住民における糖尿病と認知症の疫学研究:久山町研究. Reviewed

    中澤太郎、小原知之、二宮利治

    Dementia Japan 34: 232-238, 2020   2020.1

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  • 認知症対策におけるコホート研究と予防について.久山町研究の知見より. Reviewed

    二宮利治

    第38回日本認知症学会学術集会モーニングセミナー1記録集:   2020.1

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  • [対談]音の質を語る. Reviewed

    中石真一路、二宮利治

    月刊 臨牀と研究   2019.11

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  • 特集:認知症早期診断・発症進行予防と特集:認知症早期診断・発症進行予防とリハビリテーション. 久山町研究からみた認知症予防.リハビリテーション. 久山町研究からみた認知症予防. Reviewed

    小原知之、二宮利治

    MB Med Reha   2019.10

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  • 特集:久山町研究~59年目を迎えて~.

    二宮利治

    學士鍋   2019.10

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  • 特集:認知症と糖尿病. 疫学研究からみた糖尿病と認知症:久山町研究. Reviewed

    小原知之、二宮利治

    老年精神医学雑誌   2019.9

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  • 久山町研究からみる認知症のスガタ.

    二宮利治、小原知之

    アンサンブル   2019.9

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  • '85年から34年-住民役8千人を追跡リサーチ.福岡県久山町調査で判明したリアル数値.糖尿病患者は通常の2.1倍、認知症になる.

    二宮利治

    女性自身   2019.8

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  • 特集:糖尿病と認知症~その「危険な関係」を知る~. Ⅰ.疫学 糖尿病と認知症の疫学:久山町研究.

    二宮利治

    月刊糖尿病   2019.8

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  • 特集:老年精神医学分野におけるさまざまなタイプの認知症研究を読み解く. 認知症の疫学研究:久山町研究. Reviewed

    小原知之、二宮利治

    老年精神医学雑誌   2019.7

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  • 認知症の有病率・発症率と危険因子-久山町研究より-.

    二宮利治

    精神科臨床Legato   2019.7

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  • Ⅰ.一般住民コホート研究. 1.生活習慣病と認知症の関係:久山町研究.

    二宮利治

    The Lipid   2019.7

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  • シンポジウム①生活習慣・生活習慣病と認知症・アルツハイマー病. 司会者のことば. Reviewed

    山田正仁、二宮利治

    日本内科学会雑誌   2019.7

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  • シンポジウム①生活習慣・生活習慣病と認知症・アルツハイマー病. 1) 認知症コホート研究から(1):久山町研究. Reviewed

    小原知之、二宮利治

    日本内科学会雑誌 108: 1737-1742, 2019   2019.7

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  • 久山町研究からみた認知症対策. Reviewed

    二宮利治

    bios 24-Ⅳ: 3-6, 2019   2019.7

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  • 研究会Reports:第20回感情・行動・認知(ABC)研究会. わが国における認知症の疫学研究:久山町研究. Reviewed

    二宮利治

    分子精神医学   2019.7

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  • 血中脂肪酸バランスと疾患リスク(久山町研究).

    二宮利治

    週刊医学のあゆみ   2019.6

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  • 特集:脳卒中 -診断・治療の最新動向- Ⅰ.総論 脳卒中の疫学.

    秦 淳、二宮利治

    日本臨牀   2019.6

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  • 特集:脳血管と認知症. ●診断・臨床 高血圧および血圧変動と認知症.

    大石絵美、二宮利治

    最新医学   2019.6

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  • 連載:健康寿命延伸に寄与する体力医学. 第7回 運動と認知症:久山町研究. Reviewed

    小原知之、二宮利治

    医学のあゆみ   2019.5

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  • 将来の糖尿病発症を予測するICTツールを活用した保健指導.福岡県久山町の産官学連携による取り組み.

    吉田大悟、稲永みき、持松可奈子、石田有紀、二宮利治

    保健師ジャーナル   2019.3

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  • 認知症コホート研究の新たな展開.地域高齢住民における認知症の疫学調査:久山町研究. Reviewed

    小原知之、二宮利治

    Dementia Japan   2019.1

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  • 生活習慣病と癌セミナー. 演題:糖尿病と癌の関係:疫学的観点から.

    二宮利治

    城南区医師会誌 117: 9, 2018   2018.12

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  • 第17回新居浜認知症ネットワーク:講演要旨. 地域住民における認知症の実態とその予防-久山町研究-.

    二宮利治

    新居浜市医師会報 746: 15253, 2018   2018.12

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  • Reply to "Long sleep duration: An epiphenomenon or a risk for dementia?".

    Ohara T, Ninomiya T

    J Am Geriatr Soc 66: 2225-2226, 2018   2018.11

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  • 理論編1.身体活動・運動と介護予防.

    岸本裕歩、二宮利治

    みんなのスポーツ 448: 12-14, 2018   2018.11

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  • Ⅹ 危険因子と予防.認知症の危険因子と防御因子.

    二宮利治

    日本医師会雑誌 147 特別号: S280-S282   2018.10

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  • Japanese legacy cohort studies: the Hisayama Study.

    Ninomiya T

    J Epidemiol   2018.10

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  • 飯塚医師会学術講演会抄録 平成30年5月17日.飯塚医師会学術講演会-飯塚糖尿病と腎臓病研究会-.糖尿病性腎臓病の臨床・疫学研究.

    二宮利治

    VOICE 飯塚医師会報 145: 20-27   2018.9

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  • 特集:脂質異常と冠動脈疾患.臨床:脂質異常症と動脈硬化性疾患の疫学研究.

    秦 淳、二宮利治

    CARDIAC ORACTICE   2018.9

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  • 第3章 リポクオリティによる疾患制御. 14.脂肪酸バランスと疾患リスク(久山町研究).

    二宮利治

    実験医学   2018.9

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  • Ⅸ.高齢者の精神疾患. 認知症. 認知症の疫学. Reviewed

    二宮利治

    日本臨牀   2018.8

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  • 認知症を防ぎ治す極意.食後血糖値の急上昇を避けよ!糖尿病が認知症の発症リスクを倍増させると判明.

    二宮利治

    壮快   2018.8

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  • Serum 1,25-Dihydroxyvitamin D level is inappropriate for use in prospective studies of cancer incidence - Reply.

    Umehara K, Mukai N, Kitazono T, Hoka S, Kiyohara Y, Ninomiya T

    Circ J 82: 2216, 2018   2018.7

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  • Topics 01. 心血管病の発症率およびその危険因子の変遷:久山町研究.

    二宮利治

    日本脳ドック学会報   2018.7

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  • 特集:認知症の疫学研究とこれからの課題.認知症の発症率と危険因子-久山町研究-.

    二宮利治

    老年精神医学雑誌   2018.4

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  • 脂肪酸クオリティと疾患リスク-久山町研究から.

    二宮利治

    医学のあゆみ   2018.3

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  • 特集:激増する糖尿病の診療最前線.糖尿病の疫学.

    平川洋一郎、二宮利治

    臨牀と研究   2018.3

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  • Author response: Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community.

    Hata J, Yubi T, Ninomiya T

    Neurology: Clinical Practice   2018.2

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  • Ⅳ.認知症予防. 久山町研究から考える認知症予防.

    小原知之、二宮利治

    日本臨牀   2018.1

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  • 特集:エビデンスを2型糖尿病臨床にどう生かせばいい?‐Evidence Based Medicine をReal World へ. 糖尿病の発症予測, 発症予防, 発症後のコントロール. 糖尿病の発症予測.

    向井直子、二宮利治

    内科   2018.1

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  • 発行人対談:-今、問われるべき医療テーマ-.前例なき大型臨床研究で認知症の打開策を探る.

    二宮利治、武田 宏

    Primaria   2017.12

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  • 研究室紹介245. 九州大学大学院医学研究院衛生・公衆衛生学久山町研究室.

    二宮利治

    血圧   2017.9

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  • 久山町研究からみた認知症の予防.Prevention of dementia: the Hisayama Study.

    小原知之、清原 裕、二宮利治

    老年期認知症研究会誌   2017.9

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  • 特集:ここまで明らかになったω3脂肪酸. ミニレビュー:疫学的にみたω-3 脂肪酸の有用性.

    二宮利治

    ビタミン誌   2017.9

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  • 特集:糖尿病と動脈硬化. 1.疫学・大規模研究.

    向井直子、二宮利治

    糖尿病   2017.7

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  • 特集:あしたのアルツハイマー病治療. 健康長寿社会の実現を目指した大規模認知症コホート研究(JPSC-AD).

    二宮利治

    BRAIN and NERVE   2017.7

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  • ◆シンポジウム:目に見えるストレス:ニューロイメージング心身医学の新展開. 地域高齢者における糖尿病と海馬萎縮との関係:久山町研究.

    平林直樹、秦 淳、須藤信行、清原 裕、二宮利治

    心身医学   2017.7

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  • 6月16日(金)「糖尿病を予防する生活習慣」.

    二宮 利治

    2017.6

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  • 特集:糖尿病の日本人特異性~日本的糖尿病学の確立へ~. 久山町研究からみた日本人糖尿病の特徴.

    二宮利治

    月刊糖尿   2017.6

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  • 福岡市勤務医会平成28年度第4回学術講演会. 認知症の疫学研究~久山町研究の成績より~.

    二宮利治

    季刊 きんむ医   2017.6

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  • Ⅱ.疫学. 地域住民を対象とした疫学研究.

    秦 淳、二宮利治

    日本医師会雑誌   2017.6

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  • 医療界のキーマンに聞いた.2050年の展望.医者と医療の未来.生活習慣を改善すれば認知症患者も減らせる.

    二宮利治

    週刊 東洋経済   2017.6

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  • 6月12日(月)「健康診断では見つかりにくい血糖値の異常」.

    二宮利治

    NHKマイあさラジオ健康ライフを聴く「食後の血糖値にご用心」、ラジオ第1、2017.6   2017.6

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  • 6月13日(火)「脳梗塞や心臓疾患への影響」.

    二宮利治

    2017.6

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  • 6月14日(水)「認知症への影響」.

    二宮 利治

    2017.6

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  • 6月15日(木)「糖尿病の危険度をチェックする」.

    二宮利治

    2017.6

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  • 「疫学・要因・対策」シリーズ. 要因シリーズ1. わが国の循環器疾患の危険因子「脳卒中」.

    秦 淳、二宮利治

    日循予防誌   2017.5

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  • 特集:生活習慣病と認知症. 認知症の疫学-久山町研究.

    髙江啓太、二宮利治

    血圧   2017.3

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  • 特集:生活習慣病と認知症. 認知症の疫学-久山町研究-.

    髙江啓太、二宮利治

    血圧   2017.2

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  • 〝目からウロコ〟の最新情報.痛風・糖尿病…「1日1杯」こんなにある〝健康効果〟.牛乳が認知症予防に効く!.

    二宮利治

    サンデー毎日2月19日号   2017.2

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  • Ⅲ.各種疾患. 2.脳血管障害. 2.脳卒中と糖代謝異常・脂質代謝異常の疫学:久山町研究.

    由比智裕、二宮利治

    Annual Review 神経   2017.1

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  • 特集/ガイドラインに沿った高血圧診療. 高血圧の疫学.

    大石絵美、坂田智子、二宮利治

    臨牀と研究 94: 1-5,   2017.1

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  • 連載 トランスレーショナルリサーチへの誘い.第7回. Basic と Clinical をつなぐ生物統計学の手法.

    平川洋一郎、二宮利治

    尿酸と血糖 3: 45-50, 2017   2017.1

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  • すべて医学的に根拠があります! “エビデンス健康食”.

    二宮利治

    週刊文春12月29日号   2016.12

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  • 特別企画1 わが国のコホート研究からわかった糖尿病対策の重要性. Reviewed

    二宮利治

    月刊糖尿病ライフ さかえ56:17-21,2016   2016.11

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  • 特集:知っておきたい突然死の知識. 久山町研究からみた突然死の実態.

    坂田智子、二宮利治

    臨牀と研究   2016.11

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  • 久山町研究からわかった認知症予防.認知症予防は65歳では遅すぎる??!!.

    二宮利治

    広報ひさやま10月号 547: 7, 2016   2016.10

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  • 慢性腎臓病の疫学および臨床研究.

    二宮利治

    福岡医誌   2016.8

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  • 特集:アルツハイマー型認知症診療のBreakthrough. 生活習慣病とアルツハイマー型認知症.

    小原知之、二宮利治

    Pharma Medica   2016.7

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  • 特集:脳卒中. Ⅰ.総論. 脳卒中の疫学-日本と諸外国の比較-.

    古田芳彦、二宮利治

    日本臨床   2016.4

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  • 特集:認知症の早期発見と予防・治療-認知症500万人時代に求められるもの.ライフスタイルと認知症.

    小原知之、二宮利治

    Current Therapy   2016.3

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  • Alzheimer病の危険因子・防御因子.

    小原知之、二宮利治、清原 裕

    最新医学   2016.3

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  • 特集:腎臓病の疫学研究.慢性腎臓病の疫学:久山町研究.

    二宮 利治

    日本腎臓学会誌   2015.12

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  • 特集:健康長寿の疫学 身体活動・握力と総死亡および死因別死亡の関連.

    岸本 裕歩, 二宮 利治

    介護福祉・健康づくり   2015.12

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  • 特集/認知症の予防と早期介入:その危険因子と防御因子. 高血圧と認知症予防.

    坂田智子、二宮利治、清原 裕

    神経治療学   2015.11

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  • 特集・尿と血液からわかる腎臓病.【疫学】腎臓病の尿異常の疫学.

    二宮 利治

    腎と透析   2015.10

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  • 末梢動脈疾患と心血管病発症の関係:久山町研究.

    二宮 利治

    Arterial Stiffness 21   2015.6

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  • Interventions for lowering plasma homocysteine levels in kidney transplant recipients.

    Kang A, Nigwekar SU, Perkovic V, Kulshrestha S, Zoungas S, Navaneethan SD, Cass A, Gallagher MP, Ninomiya T, Strippoli GF, Jardine M

    Cochrane Database Syst Rev 5   2015.5

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  • Patterns of Japanese Diet and Risk of Dementia

    Ninomiya T

    Curr Nutr Rep 4   2015.4

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  • Stroke and cerebrovascular diseases in patients with chronic kidney disease

    Toyoda K, Ninomiya T

    Lancet Neurol 13: 823-833, 2014   2014.8

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  • baPWVと心血管病:久山町研究.

    二宮 利治, 小島 巌, 土井康文, 福原正代, 平川洋一郎, 秦 淳, 北園孝成, 清原 裕

    Arterial Stiffness 20   2014.5

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  • Diabetes mellitus and dementia

    Ninomiya T

    Curr Diab Rep 14: 487, 2014   2014.1

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  • 特集:今日から役立つ高血圧診療のノウハウ. 高血圧の現状を知る. 高血圧と合併リスク変遷

    二宮 利治

    medicina 50: 1338-1341, 2013   2013.8

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  • Diabetes mellitus and cancer risk: Review of the epidemiological evidence

    Shikata K, Ninomiya T, Kiyohara Y.

    Cancer Sci 104: 9-14, 2013   2013.2

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  • Antioxidants for chronic kidney disease

    Jun M, Venkataraman V, Razavian M, Cooper B, Zoungas S, Ninomiya T, Webster AC, Perkovic V

    Cochrane Database Syst Rev, CD008176, 2012   2012.12

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  • Hypertension in the older patient: practical clinical management.

    Ninomiya T

    Clinical Medicine Reviews in Vascular Health 4: 29-42, 2012   2012.4

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  • 日本人高齢者における中年期および老年期血圧レベルと認知症の関係:久山町研究.

    二宮 利治、清原 裕

    血圧 19:4-5、2012   2012.2

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  • 特集:高血圧治療最前線 V. 特論 高血圧と認知症.

    二宮 利治、清原 裕

    日本臨牀 69: 2064 -2070, 2011   2011.10

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  • Is metabolic syndrome a risk factor for cardiovascular disease in late elderly?

    Ninomiya T

    Am J Hypertens 24: 1193, 2011   2011.5

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  • 特報:2010年度井村臨床研究奨励賞受賞記念論文. 慢性腎臓病と心血管病に関する疫学・臨床研究.

    二宮 利治

    最新医学 66: 139-146, 2011   2011.4

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  • 認知症. 高血圧+耐糖能異常の予防・管理が重要

    二宮 利治

    Medical ASAHI 4: 26-27, 2011   2011.1

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  • Topics-脳血管障害治療の今. 脳卒中とCKD.

    二宮 利治

    Stroke-Expert Network 2: 7-9, 2010   2010.12

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  • Albuminuria and eGFR predict cardiovascular and renal risk.

    [No author list].

    Nature Review Nephrology 5: 606, 2009   2009.11

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  • Routine administration of a fixed combination of perindopril-indapamide reduced the risk of kidney events in diabetes.

    Ninomiya T, Perkovic V.

    AUANews 2009   2009.6

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  • 久山町研究2009 update. メタボリックシンドロームと心血管病.

    二宮 利治, 清原 裕.

    醫學のあゆみ 228: 285-288, 2009   2009.1

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  • Efficacy and safety of fixed combination of perindopril and indapamide in type 2 diabetes: results from ADVANCE in context of available evidence

    Chalmers J, Joshi R, Kengne AP, Ninomiya T, Bi Y, Bompoint S, Billot L, Patel A; ADVANCE Collaborative Group.

    J Hypertens 26 Suppl 3: S21-S27, 2008   2008.9

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  • Low blood pressure does protect against stroke in CKD.

    [No author list].

    Nature Clinical Practice Nephrology 4: 291, 2008   2008.6

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  • CKD慢性腎臓病の臨床・セミナー. 久山町研究におけるCKDの実態.

    永田 雅治, 二宮 利治, 清原 裕.

    Medical Practice 25: 229-234, 2008   2008.2

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  • 心腎連関の疫学.

    永田 雅治, 二宮 利治, 清原 裕.

    循環器科 63: 119-124, 2008   2008.2

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  • メタボリックシンドロームの臨床. メタボリックシンドロームの実態.

    清原 裕, 土井 康文, 二宮 利治.

    日本内科学会雑誌 95: 1710-1715, 2006   2006.5

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  • 一般住民における慢性腎臓病と心血管病発症の関係: 久山町研究. ‐第50回日本透析医学会・第48回日本腎臓学会合同ワークショップより‐

    二宮 利治, 清原 裕, 久保 充明, 平方 秀樹, 飯田 三雄.

    日本透析医学会雑誌 39, 94-96, 2006   2006.1

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  • 一般住民における慢性腎臓病と心血管病発症の関係: 久山町研究.

    二宮 利治, 清原 裕, 久保 充明, 平方 秀樹, 飯田 三雄.

    日本透析医学会雑誌 39, 94-96, 2006   2006.1

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  • メタボリックシンドロームの疫学.

    二宮 利治, 清原 裕.

    動脈硬化予防 5: 56-61, 2006   2006.1

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  • 高ホモシステイン血症に対する薬物療法.

    池田 裕史, 篠崎 倫哉, 二宮 利治, 平方 秀樹.

    腎臓26: 242-252, 2004   2004.3

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  • Question 高血圧者の数は?

    二宮 利治, 清原 裕, 久保 充明, 平方 秀樹, 飯田 三雄.

    肥満と糖尿病 3: 26-27, 2004   2004.1

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  • 患者さんのひとことがヒント 透析ナースの食事指導ガイド: 慢性腎不全患者さんのこの「ひとこと」を聞いたら? 身体の悩み 「困ったことになった!」という患者さんへの食事指導.

    二宮 利治, 阿部 由美子, 金井 英俊, 平方 秀樹.

    透析ケア 冬季増刊: 46-60, 2001   2001.12

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  • 透析導入 最近の実態とあり方: 透析療法導入期の既存障害の実態 脳神経(CVA後遺症など).

    平方 秀樹, 二宮 利治.

    臨床透析17: 872-884, 2001   2001.6

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Industrial property rights

Patent   Number of applications: 2   Number of registrations: 0
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • 日本高血圧学会

  • 日本透析医学会

  • 日本腎臓学会

  • 日本脳卒中学会

  • 日本老年医学会

  • 日本疫学会

  • 日本動脈硬化学会

  • 日本内科学会

  • 日本公衆衛生学会

  • International Society of Hypertension

  • 日本未病学会

  • 日本認知症学会

  • 日本循環器学会

  • 日本衛生学会

  • 衛生学・公衆衛生学教育協議会

  • 福岡医学会

  • 日本循環器病予防学会

  • 日本臨床疫学会

  • 一般社団法人 社会医学系専門医協会

  • American Heart Association

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  • 福岡医学会

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  • 社会医学系専門医協会

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  • 日本高血圧学会

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  • JAPAN SOCIETY FOR DEMENTIA RESEARCH

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  • THE JAPANESE SOCIETY FOR HYGIENE

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  • 日本臨床疫学会

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  • JAPANESE SOCIETY OF NEPHROLOGY

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  • 日本脳卒中学会

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  • THE JAPAN GERIATRICS SOCIETY

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  • THE JAPAN DIABETES SOCIETY

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  • JAPAN EPIDEMIOLOGICAL ASSOCIATION

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  • JAPAN MIBYOU SYSTEM ASSOCIATION

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  • 日本慢性疾患重症化予防学会

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  • 日本心血管脳卒中学会

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  • The Japanese Circulation Society

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  • 日本循環器予防学会

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  • JAPANESE SOCIETY FOR ORAL HEALTH

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  • JAPAN ATHEROSCLEROSIS SOCIETY

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  • THE JAPANESE SOCIETY OF INTERNAL MEDICINE

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  • JAPANESE SOCIETY OF PUBLIC HEALTH

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  • International Society of Hypertension

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  • American Society of Nephrology

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Committee Memberships

  • 日本未病学会   Executive   Domestic

    2023.4 - Present   

  • ふくおか公衆衛生推進機構   Executive   Domestic

    2021.7 - 2023.6   

  • 日本循環器予防学会   Executive   Domestic

    2021.6 - Present   

  • 日本臨床疫学会   Executive   Domestic

    2017.10 - Present   

Research Projects

  • 唾液成分組成の長期動態の理解に基づく口腔常在微生物叢の老化メカニズムの解明

    Grant number:25K02838  2025.4 - 2029.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    竹下 徹, 二宮 利治, 古田 美智子, 影山 伸哉, 中野 善夫

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    Grant type:Scientific research funding

    口腔常在微生物叢における常在細菌の構成バランスの悪化に加齢が関連することが明らかとなってきた。高齢期に入り微生物叢の制御を担う唾液の質が低下し、この口腔常在微生物叢の老化をもたらしている可能性が考えられる。本研究では我々が過去に行った3回の調査で取得した成人地域住民の唾液に含まれる成分組成を決定し、加齢変化の詳細を明らかにするとともに微生物叢の構成バランス悪化に関わる成分を特定する。本研究の成果は生涯にわたる健康な口腔常在微生物叢の維持を実現するうえで重要な基盤データとなる。

  • 心電図から予後予測モデルの開発:AIを用いた挑戦

    Grant number:25K13589  2025.4 - 2028.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    大石 絵美, 秦 淳, 遠山 岳詩, 二宮 利治, 坂田 智子

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    Grant type:Scientific research funding

    日本の地域住民を対象とした前向きコホート研究(久山町研究)の成績を用いて、健診時の心電図データから予後を予測する心電図AIモデルを作成し(ECG-AIモデル)、さらに、生活習慣や遺伝情報から推定される予測確率を組み合わせて(ECG-AI複合モデル)比較検討することにより、疾患発症予測モデルの性能を検証し、わが国における疾患発症のリスク評価に有効な新たな指標を創出することを目的とする。

  • 口腔細菌が引き金となる腸管dysbiosisの理解とその予防に向けたリスク因子の特定

    Grant number:24K02660  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    影山 伸哉, 古田 美智子, 二宮 利治, 竹下 徹, 坂田 智子

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    Grant type:Scientific research funding

    口腔には膨大な数の細菌が複雑な常在細菌叢(マイクロバイオーム)を構築して生息しており、我々はこれらの細菌を嚥下の度に飲み込んでいる。一方、様々な疾患患者の腸管マイクロバイオームから多量の口腔細菌が検出されることが報告され、口腔細菌の異所性定着が疾患発症に関わっていると考えられるようになってきた。本研究では便検体と唾液検体を用いてロングリードシークエンサーによるマイクロバイオーム解析を行い、腸管マイクロバイオームで検出される口腔細菌の比率や種類を把握する。さらに口腔細菌の腸管異所性定着に寄与する口腔・全身のリスク因子を同定する。

    CiNii Research

  • Gender difference in the association between oral and systemic with focusing on bone metabolism

    Grant number:24K13242  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    古田 美智子, 竹下 徹, 溝上 顕子, 二宮 利治

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    Grant type:Scientific research funding

    本研究では地域住民を対象にして歯科健診を実施し、また過去に取得した健診データを用いて口腔状態の変化を評価し、健診で採取した血漿試料を用いて骨代謝調節因子のosteoprotegerin (OPG)を測定する。健診データと血漿中のOPG濃度についてのデータを解析し、女性では閉経後にOPGが低下し、その低下量は肥満の者で大きく、それに応じて口腔の状態がより悪化しているかを明らかにする。また、閉経後の女性において、肥満と口腔状態の悪化に関係があることを確認し、OPGがこの関係を媒介していることを明らかにする。

    CiNii Research

  • 脳筋連関・TREM2に着目した糖尿病性認知症・コグニティブフレイルの予防戦略開発

    Grant number:24K02363  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    浅原 哲子, 猪原 匡史, 二宮 利治

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    Grant type:Scientific research funding

    本研究は超高齢社会における認知症抑制に向け、糖尿病に伴う認知症・コグニティブフレイル進展機序の解明と効果的予防法の確立を目的とする。本研究では申請者が既に構築した複数コホート(一般住民/健診/糖尿病・肥満/認知症)と新規血液マーカー測定系(sTREM2・Aβ・タウ)やTREM2欠損マウス等を基盤に、以下を検討する。
    ①糖尿病における認知症・コグニティブフレイルの実態・リスク因子と進展機序の解明
    ②効果的な予知バイオマーカー・評価パネルと効果的な予防戦略の確立
    以上より、TREM2を標的とした糖尿病性認知症・フレイルの新たな革新的予知指標・高リスク群早期検出法と予防・治療戦略の開発を目指す。

    CiNii Research

  • 脂質の質と性差に着目した脂質指標と心血管病・認知症との関連:久山町研究

    Grant number:23K09717  2023.4 - 2028.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    坂田 智子, 二宮 利治, 大石 絵美

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    わが国では、高齢人口の増加に伴い介護を要する患者数が増加し、医学・社会的な問題となっている。要介護状態の原因疾患として心血管病や認知症が挙げられ、脂質異常症は心血管病の主たる危険因子であるため、その管理が重要である。
    脂質異常症の心血管病へ与える影響には性差があると考えられている。脂質指標には、LDLコレステロールをはじめ様々な指標があり、これらの組成に性差があるか、それが疾病発症に与える影響について検討した報告は少ない。そこで本研究課題では福岡県久山町の地域住民を対象とした疫学研究の成績を用いて、各脂質指標の組成の男女差について明らかにし、その心血管病、認知症との関連について縦断的に検討する。

    CiNii Research

  • 前向きコホート研究に基づいたOCT緑内障発症リスク予測モデルの開発

    Grant number:23K09060  2023.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    藤原 康太, 園田 康平, 二宮 利治, 上田 瑛美

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    Grant type:Scientific research funding

    高齢化が進む現代において緑内障の有病率は増加しており(2017年久山町研究)、緑内障による失明者もますます増加することが懸念されている。この社会課題を克服するためには、緑内障発症リスクの高い患者を事前に発見し、早期に治療介入することが必要である。本研究では地域一般住民を対象としてOCTを活用した緑内障の追跡調査を実施し、OCTから得られる網羅的眼データと網羅的全身因子データを合わせて緑内障発症率との関連を解析することで、緑内障発症リスク予測モデルを確立する。本研究成績から緑内障を未病で発見し、より早期からの高リスク群の同定が可能となり、失明防止に貢献することが期待できる

    CiNii Research

  • 新しい網膜血管定量解析を用いた脳萎縮予測のための網膜パラメータ意義の検証

    Grant number:23K06787  2023.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    上田 瑛美, 園田 康平, 二宮 利治

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    Grant type:Scientific research funding

    本課題では、健診眼底画像を用いて、1)網膜静脈血管蛇行度と脳萎縮部位との関連、2)網膜動脈血管径と脳微小血管障害発症との関連を検討することを目的とする。古くから、眼底から脳を視る研究は行われており、眼底画像解析技術が進歩した今、研究を行う好機である。そこから得られるエビデンスは、健診で認知症の脳形態的特徴を早期発見する優しい検査を提供するとともに、「脳の健康」の実現に向けて極めて重要な意義があると考えられる。

    CiNii Research

  • Risk prediction of atrial fibrillation, cardiovascular diseases, and dementia using electrocardiogram findings: the Hisayama Study

    Grant number:23K09692  2023.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    秦 淳, 二宮 利治

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    心電図は不整脈の診断において必須の検査であり、さらに電気活動の変化に基づき心臓の器質的・形態学的異常を推定することにより、不整脈以外の心疾患全般の診断においても有用である。しかし、心電図所見を用いてこれらの心疾患の発症を未然に予測することが可能かどうかという点においては、十分解明されているとはいえない。
    本研究では、福岡県久山町における長期にわたる疫学調査の成績を用いて、心電図指標が心房細動および虚血性心疾患の発症に及ぼす影響について明らかにする。さらに、心疾患との連関が想定される他の臓器障害(脳卒中、認知症、高血圧、慢性腎臓病など)の発症や死亡に及ぼす種々の心電図指標の影響についても検討する。

    CiNii Research

  • 15年コホートに基づく口腔常在微生物叢の長期動態と構成異常をもたらす要因の解明

    Grant number:23K24561  2022.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    竹下 徹, 古田 美智子, 二宮 利治, 山下 喜久

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    Grant type:Scientific research funding

    口腔常在微生物叢の構成バランスの異常と健康との関連が注目を集めている一方で微生物叢が異常に至る経緯は不明なままである。本研究では2007年に開始した口腔常在微生物叢調査の追跡調査を行い、高精度微生物群集解析法を用いて口腔常在微生物叢構成の15年追跡データセットを構築する。これに基づき口腔常在微生物叢の正常な加齢変化を定義し、微生物叢構成の異常と健康悪化との関係性を解明する。さらに健康悪化に先んじてみられる構成異常に関わる宿主要因及びその病原メカニズムを探索する。世界に先駆けた口腔常在微生物叢の長期動態の解明は微生物叢の異常に先制的に介入する新たな口腔保健管理手法の開発の礎ともなる。

    CiNii Research

  • 病的近視発症リスク予測モデルの開発に向けた前向きコホート研究

    Grant number:22K09767  2022.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    安田 美穂, 園田 康平, 二宮 利治, 上田 瑛美, 藤原 康太

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    Grant type:Scientific research funding

    病的近視は、わが国の失明原因の上位を占め、網膜の変性により進行性の視覚障害をきたす疾患である。しかしながら、病的近視が発症する要因については十分に解明されていない。病的近視発症には全身因子・遺伝因子・環境因子が複雑に絡み合っていると考えられる。病的近視の増加に歯止めをかけ、その予防を含めた総合的な対策を構築するためには、疫学研究によって地域住民における病的近視の実態を把握し、危険因子・防御因子を同定することは必要不可欠である。本研究では日本人の病的近視に関わる眼科的因子、全身因子、遺伝因子を明らかにし、病的近視発症リスク予測モデルを確立する。

    CiNii Research

  • 地域一般住民における心理社会的因子が慢性疼痛とQOLに及ぼす影響:久山町研究

    Grant number:22K07421  2022.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    柴田 舞欧, 二宮 利治

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    Grant type:Scientific research funding

    日本人の代表的サンプルと考えられる久山町地域一般住民約2700名を対象に、慢性疼痛の発症を追跡調査し、心理社会的要因(被養育体験、失感情症、自己肯定感、過剰適応、家族機能、情緒的孤独感)との関連を横断的および縦断的に検討する。追跡研究を行い縦断的に検討することで、これらの因果関係を明らかにすることができる。また、2023年に家族構成、子どもの数、生活満足度を調査し、家庭や子どもを持つことおよび生活満足度に関連する心理社会的要因を明らかにし、慢性疼痛の有無でその関連に違いが見られるか検討する。

    CiNii Research

  • フレイルに起因する老年性疾患の予防に寄与する食事性因子の解明:久山町研究

    Grant number:21K11725  2021.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    木村 安美, 吉田 大悟, 二宮 利治

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    Grant type:Scientific research funding

    本研究では、2012年に福岡県久山町の高齢者調査を受診した65歳以上の住民のうち、本研究への同意が得られた約1900人を対象に食品摂取の多様性、栄養素・食品摂取量と老年性疾患(サルコペニア、認知機能低下、認知症等)との関連について横断的に検討する。次に、2012年に老年性疾患を有さない高齢住民約1500名を2022年(10年後)まで追跡し、老年性疾患発症に与える長期的影響度の高い食事性因子を特定・解明する。本研究課題の成果は高齢者が住み慣れた地域で長く自立した生活を維持するためのエビデンスとして活用され、介護予防や健康寿命の延伸、医療費の削減など健全な超高齢社会の実現に寄与しうるものと考える。

    CiNii Research

  • Cross-sectional and longitudinal study to elcidate the actual status of dementia and its secular change among older residents in Hisayama town

    Grant number:21K07522  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Ohara Tomoyuki

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    Grant type:Scientific research funding

    By using the follow-up data of the development of dementia, we revealed that the influence of daily sleep duration on the risk of dementia differed according to serum sTREM2 levels. In addition, the risk of dementia increased significantly with higher white matter lesions volume-to-intracranial brain volume ratio (WMLV/ICV) levels. An additive increment in dementia risk was observed with higher WMLV/ICV levels and lower total brain volume-to-ICV levels. A cross-sectional study of dementia in an older population showed that individuals with impaired olfactory identification or inner retinal thickness had significantly higher prevalence of dementia/mild cognitive impairment and lower volume of hippocampus, amygdala, temporal lobe, and occipital lobe than those without. Furthermore, the decreasing trends in the prevalence of dementia were observed since 2012 in a Japanese older population, probably due to the decrement of incidence of dementia.

    CiNii Research

  • Development of novel evaluation system and prevention strategies for dementia associated with diabetes and obesity focusing on the fat-brain crosstalk and TREM2

    Grant number:21H02835  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Satoh-Asahara Noriko

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    Grant type:Scientific research funding

    We reported in a longitudinal analysis of the NHO multicenter obesity and diabetes cohort that an initially higher sTREM2 level would be a novel predictive marker of cognitive impairment in the non-obese diabetic HbA1c-elevated group. In the dementia/MCI cohort, we also proposed a novel evaluation system for the characteristics and prediction of dementia in T2DM, showing that a decrease in sTREM2 level due to microglial dysfunction could be a starting point for the progress of dementia in the diabetic group. Furthermore, TREM2-knockout mice exhibited that TREM2 could be implicated in glucose metabolism disorders. In addition, taxifolin and imeglimin exhibited anti-inflammatory effects on high-glucose stimulated mouse microglia. In conclusion, our the results are expected the development of effective prevention strategies for dementia in T2DM and contribute to medical care and welfare by extending healthy life expectancy and reducing medical costs in Japan's super-aging society.

    CiNii Research

  • Exploring gender difference in the association between oral and systemic health by the mediation analysis

    Grant number:21K10229  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Furuta Michiko

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    Grant type:Scientific research funding

    The aim of this study was to determine serum levels of retinol binding protein-4 (RBP4), which is related to insulin resistance, and to investigate whether RBP4 influenced sex differences in the association between obesity and periodontal disease. However, no association between obesity → RBP4 → periodontal disease was observed. On the other hand, causal mediation analysis showed an association between obesity → high-sensitivity CRP → periodontal disease in women. In this association, there was no direct effect and an indirect effect was found, with a mediation rate of 47.8%. Considering the results for RBP4 in the present study, it is suggested that the association between obesity and periodontal disease is mediated by inflammatory status, but not by insulin resistance in women.

    CiNii Research

  • Secular trends in the incidence of cardiovascular disease according to blood pressure control levels in a Japanese community: the Hisayama Study

    Grant number:21K10448  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Oishi Emi

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    Grant type:Scientific research funding

    Community surveys took place in 1961, 1973, 1983, 1993, 2002, 2007, 2012, and 2017 in a Hisayama town of Japan. Overall, the blood pressure control status of hypertensives was steadily improving over the 50 years due to the widespread use of antihypertensive drugs. However, approximately half of the hypertensives had inadequate blood pressure control. Furthermore, we established 2 cohorts consisting of residents aged 40-79 years in a Japanese community, in 1974 (n=1972) and 2002 (n=2854), and followed up each cohort for 15 years. The impact of abnormal blood pressure on the development of cardiovascular disease has decreased over time. On the other hand, the risk of developing cardiovascular disease was higher in those with elevated or poorly controlled blood pressure above hypertension than in normotensive individuals.

    CiNii Research

  • A community-based cohort study on the gut microbiota and the lifestyle-related diseases, dementia, and depression: the Hisayama Study

    Grant number:21H03200  2021 - 2023

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Ninomiya Toshiharu

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    Authorship:Principal investigator  Grant type:Scientific research funding

    Recently, the influence of the gut microbiota on lifestyle-related diseases and geriatric disease has been attracting attention. In this study, we investigated the association between the gut microbiota and metabolic Syndrome (MetS) among 1,648 residents aged 40 and over who underwent health examinations in 2017-18 in Hisayama Town, Fukuoka Prefecture. The results showed that the odds ratio of the presence of MetS decreased with higher proportion of Bifidobacterium. Additionally, when examining the relationship with frailty in subjects aged 65 and over, it was found that the odds ratio of the presence of frailty significantly decreased with higher proportions of Feacalibacterium, Akkermansia, and Lachnospira. On the other hand, there were no significant associations between the gut microbiota and the volumes of various brain regions and white matter lesions.

    CiNii Research

  • 地域高齢者における将来の生活機能障害発生を予測するモデルの開発とその社会実装

    Grant number:20K11020  2020.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    吉田 大悟, 木村 安美, 二宮 利治

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    Grant type:Scientific research funding

    本研究では、2012年度に福岡県久山町の高齢者調査を受診した65歳以上の住民のうち、本研究の同意が得られた約1500人を対象に生活機能障害の有病率とその危険因子について横断的に検討する。次に、2012年に生活機能障害を有さない高齢住民約1000人を2022年(10年後)まで追跡し、生活機能障害の発生の危険因子・防御因子の検討と将来の生活機能障害発生を予測するリスクスコアモデルを算出する。本研究課題の成果は介護予防や健康寿命の延伸を達成するためのエビデンスとして活用され、疾病の発症予防や介護予防、そして医療・保健・福祉にかかる社会保障費の削減など健全な超高齢社会の実現に貢献しうるものと考える。

    CiNii Research

  • Biomakers and genetic factors for the development of atrial fibrillation in a general population: the Hisayama Study

    Grant number:20K10503  2020.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Hata Jun

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    Grant type:Scientific research funding

    (1) We developed a risk prediction model for the incident atrial fibrillation (AF) using the prospective data from the Hisayama Study. This model included age, sex, systolic blood pressure, waist circumference, estimated glomerular filtration rate, abnormal cardiac murmur, high R-wave amplitude on electrocardiogram, and arrhythmia other than AF. (2) We reported that higher levels of serum high-sensitivity C-reactive protein (hs-CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were risk factors for the incident AF using the data from the Hisayama Study. (3) We confirmed that a single nucleotide polymorphism which was reported to be a candidate gene of AF in a Western study was associated with the risk of incident AF using the data from the Hisayama Study.

    CiNii Research

  • Global cardiovascular Risk Consortium International coauthorship

    2019.11

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    Authorship:Coinvestigator(s) 

    心血管病のコホート研究の統合解析研究

  • Association between psychosocial factors and lifestyle-related diseases in a community-dwelling Japanese population: the Hisayama Study

    Grant number:19K07890  2019.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Shibata Mao

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    Grant type:Scientific research funding

    Objective: To investigate associations between parenting styles during childhood and diabetes in adulthood in a Japanese community. Methods: 710 community-dwelling Japanese residents aged 40 years or older were assessed for the presence of diabetes and for their perceptions of the parenting style of their parents, as measured using the “care” and “overprotection” scales of the Parental Bonding Instrument. Results: Subjects with a high paternal overprotection score had a significantly greater likelihood of prevalent diabetes than those with a low paternal overprotection score (Odds Ratio [OR] 1.71). Additionally, the ORs for the presence of diabetes were significantly higher in subjects with a low maternal care score (OR 1.61) or in subjects with a high maternal overprotection score (OR 1.73). Conclusions: This study suggests that inadequate care and excessive overprotection during childhood may contribute to the development of diabetes in adulthood.

    CiNii Research

  • EPOCH-JAPAN

    2016.6

  • Japan Arteriosclerosis Longitudinal Study(JALS)

    2016.6

  • Emerging Risk Factors Collaboration International coauthorship

    2016.6

  • VARIABLE BRAIN consortium International coauthorship

    2016.6

  • FORCE collaboration International coauthorship

    2016.6

  • COSMIC collaboration International coauthorship

    2016.6

  • NCD Risk Factor Collaboration International coauthorship

    2016.6

  • 健康長寿社会の実現を目指した大規模認知症コホート研究

    2016.4 - 2021.3

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    Authorship:Principal investigator 

  • Asia-Pacific Cohort Studies Collaboration(APCSC) International coauthorship

    2016.4

  • 認知症・生活習慣病研究とビッグデータ解析の融合による画期的な疾患予兆発見の仕組み構築と予防法の開発

    2016 - 2021

    Grants-in-Aid for Scientific Research  センター・オブ・イノベーション(COI)プログラム

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 8020から8028へのパラダイムシフトを目指す日韓国際比較研究

    Grant number:16H05850  2016 - 2020

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 宿主応答を累加した分子疫学的アプローチによる口腔マイクロバイオームの病原性解明

    Grant number:16H02692  2016 - 2020

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 健康長寿社会の実現を目指した大規模認知症コホート研究

    Grant number:16dk0207025h0001  2016 - 2020

    Grants-in-Aid for Scientific Research  長寿・障害総合研究事業 認知症研究開発事業

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    Authorship:Principal investigator  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 一般住民における心理社会的因子・家族機能・社会脳と認知症の関連:久山町研究

    Grant number:16K09244  2016 - 2018

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 久山町高齢者におけるMRIを基盤とした認知症・うつ病発症の前向きコホート研究

    Grant number:16H02644  2016 - 2018

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 一般住民における心理社会的因子・家族機能・社会脳と認知症の関連:久山町研究

    Grant number:16K09244  2016 - 2018

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 社会的要因を含む生活習慣病リスク要因の解明を目指した国民代表集団の大規模コホート研究:NIPPON DATA80/90/2010

    Grant number:H25-循環器等(生習)-指定-022  2016 - 2018

    Grants-in-Aid for Scientific Research  Grants-in-Aid for Scientific Research (Ministry of Health, Labour and Welfare)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 組織修復に基づく恒常性維持機構の変容による生活習慣病の病態解明と制御

    Grant number:15gm0610007h0203  2016 - 2017

    Grants-in-Aid for Scientific Research 

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 循環器疾患における集団間の健康格差の実態把握とその対策を目的とした大規模コホート共同研究

    Grant number:H26-循環器等(政策)-一般-001  2016

    Grants-in-Aid for Scientific Research  Grants-in-Aid for Scientific Research (Ministry of Health, Labour and Welfare)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 久山町一般住民におけるむずむず脚症候群と脳心血管病についての検討

    Grant number:15K08737  2015 - 2017

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 睡眠を核とする生活習慣病の予防と改善に向けたヘルスプロモーションの為の基盤構築

    Grant number:15H05104  2015 - 2017

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 食品を介したダイオキシン類等の人体への影響の把握とその治療法の開発等に関する研究

    Grant number:H27-食品-指定-017  2015 - 2017

    Grants-in-Aid for Scientific Research  Grants-in-Aid for Scientific Research (Ministry of Health, Labour and Welfare)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 心房細動発症リスクと重症化リスクの層別化指標の確立を目的とした大規模コホート・レジストリー共同研究

    Grant number:15ek0210042h0001  2015 - 2017

    Grants-in-Aid for Scientific Research 

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 地域一般住民において慢性腎臓病と脂質異常症が心血管病発症に及ぼす影響:久山町研究

    Grant number:15K09267  2015

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 久山町高齢住民における認知症の実態とその危険因子・防御因子の解明に関する縦断研究

    Grant number:15K09835  2015

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 地域住民における血糖関連バイオマーカーと糖尿病合併症に関する追跡研究

    Grant number:15K08738  2015

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 日本における認知症の高齢者人口の将来推計に関する研究

    Grant number:H26-特別-指定-036  2014

    Grants-in-Aid for Scientific Research  Grants-in-Aid for Scientific Research (Ministry of Health, Labour and Welfare)

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    Authorship:Principal investigator  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 食品を介したダイオキシン類等の人体への影響の把握とその治療法の開発等に関する研究

    Grant number:H24-食品-指定-014  2014

    Grants-in-Aid for Scientific Research  Grants-in-Aid for Scientific Research (Ministry of Health, Labour and Welfare)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • センター・オブ・イノベーション(COI)プログラム

    2013.4 - 2021.3

    弘前大学 

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    Authorship:Coinvestigator(s) 

  • 脂質メディエーター関連遺伝子のSNPと疾患

    2012

    Japan Society for the Promotion of Science・Ministry of Education, Culture, Sports, Science and Technology  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research on Innovative Areas

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • アルツハイマー病の危険因子の解明と予防に関する大規模ゲノム疫学研究

    2012

    Grants-in-Aid for Scientific Research  Grants-in-Aid for Scientific Research (Ministry of Health, Labour and Welfare)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 糖尿病性腎症の治療薬に関する臨床的評価方法確立に関する研究

    2011

    Grants-in-Aid for Scientific Research  Grants-in-Aid for Scientific Research (Ministry of Health, Labour and Welfare)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 一般住民における血清シスタチンC値と心血管病の関係:久山町研究

    Grant number:20590892  2010 - 2012

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 糖尿病性腎症の病態解明と新規治療法確立のための評価法の開発

    2010 - 2011

    Grants-in-Aid for Scientific Research  Grants-in-Aid for Scientific Research (Ministry of Health, Labour and Welfare)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 一般住民における活性型ビタミンD低下が心血管病発症・死亡に与える影響

    2010

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    Grant type:Donation

  • 地域住民における高齢者認知症に関する研究

    2010

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    Grant type:Donation

  • ISH Visiting Postdoctoral Award 2008  “Blood pressure and chronic kidney disease”.

    2008

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    Grant type:Donation

  • ISH Visiting Postdoctoral Award 2007 “Blood pressure and chronic kidney disease”.

    2007

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    Grant type:Donation

  • Banyu Fellowship Program -疫学・生物統計学領域- “慢性腎臓病患者の治療対象血圧値および降圧目標の検討”

    2006

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    Grant type:Donation

  • 慢性疼痛難治例の症例対照研究:中枢性感作に関する愛着・認知・情動とバイオマーカー

    Grant number:19H03752 

    細井 昌子, 坂本 英治, 柴田 舞欧, 二宮 利治, 安野 広三, 外園 栄作

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    Grant type:Scientific research funding

    慢性疼痛難治例において、愛着(オキシトシン系の異常)、認知(中枢性感作、安静時脳活動の異常)とそれに伴う情動系の異常(失感情&失体感)とそれを発散するための行動面の結果(自律神経系の機能異常、筋肉や関節の疲弊)に関与するバイオマーカーを検索し、慢性疼痛難治化に関連する中枢性感作とそれに伴う多様な病態を明らかにする。

    CiNii Research

  • 大規模前向きコホートデータを基盤とした認知症のゲノム・脳画像研究

    日本医療研究開発機構研究  認知症研究開発事業 

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    Authorship:Principal investigator 

  • 舌苔マイクロバイオームの管理に基づく新たな慢性呼吸器疾患予防アプローチの構築

    Grant number:19H03863 

    竹下 徹, 松元 幸一郎, 二宮 利治, 古田 美智子

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    Grant type:Scientific research funding

    呼吸器における慢性炎症は気流制限を引き起こし重症化すれば呼吸不全から死に至る。COPDと呼ばれるこの疾患の原因は喫煙がよく知られているがその他の炎症誘発因子の特定と対策も急がれている。本研究では我々が常時大量に飲み込んでいる口腔常在微生物叢に着目し、その量や質の悪化と発症・増悪との関連を検討する。重症COPD患者と健常地域住民との舌苔微生物叢大規模比較解析からCOPD関連微生物叢パターンを解明するとともに、微生物叢管理法の構築を目指し唾液中の微生物叢制御成分を特定する。本研究の結果は舌苔微生物叢管理という全く新たな視点からの慢性呼吸器疾患予防アプローチの構築にむけた重要な礎となる。

    CiNii Research

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Educational Activities

  • 医学部4年生・6年生:衛生・公衆衛生学講義
    大学院生:疫学講義、研究指導
    基幹教育における講義:アカデミックフロンティア、生命の科学

Class subject

  • 医学部4年生:衛生・公衆衛生学

    2025.7 - 2025.9  

  • 医学専攻博士課程:医学研究特論I

    2025.5  

  • 歯学部4年生:歯科全身管理学

    2025.5  

  • 医学専攻博士課程:疫学研究

    2024.8  

  • 医学部4年生:衛生・公衆衛生学

    2024.7 - 2024.9  

  • 歯学部4年生:歯科全身管理学

    2024.5  

  • 医学部4年生:衛生・公衆衛生学

    2023.10 - 2024.3   Second semester

  • 医学専攻博士課程:疫学研究

    2023.8  

  • 歯学部4年生:歯科全身管理学

    2023.5   First semester

  • 医学専攻博士課程:医学研究特論I

    2023.4 - 2023.9   First semester

  • 生命の科学A

    2023.4 - 2023.6   Spring quarter

  • 医学部4年生:衛生・公衆衛生学

    2022.10 - 2023.3   Second semester

  • 医学専攻博士課程:疫学研究

    2022.8   First semester

  • 総合コホートセンターを基盤とした新知見発掘の推進と国際的人材(新世代コホート研究リーダー)育成プログラム

    2022.4 - 2026.3   Full year

  • 医学部6年生:衛生・公衆衛生学

    2022.4 - 2022.9   First semester

  • 歯学部4年生:歯科全身管理学

    2022.4 - 2022.9   First semester

  • 医学部4年生:衛生・公衆衛生学

    2021.10 - 2022.3   Second semester

  • 総合コホートセンターを基盤とした新知見発掘の推進と国際的人材(新世代コホート研究リーダー)育成プログラム

    2021.4 - 2022.3   Full year

  • 医学専攻博士課程:疫学研究

    2021.4 - 2021.9   First semester

  • 歯学部4年生:歯科全身管理学

    2021.4 - 2021.9   First semester

  • 医学専攻博士課程:医学研究特論I

    2021.4 - 2021.9   First semester

  • アカデミック・フロンティア

    2021.4 - 2021.9   First semester

  • 医学部6年生:衛生・公衆衛生学

    2021.4 - 2021.9   First semester

  • 生命の科学A

    2021.4 - 2021.6   Spring quarter

  • 医学部4年生:衛生・公衆衛生学

    2020.10 - 2021.3   Second semester

  • 総合コホートセンターを基盤とした新知見発掘の推進と国際的人材(新世代コホート研究リーダー)育成プログラム

    2020.4 - 2021.3   Full year

  • 医学専攻博士課程:疫学研究

    2020.4 - 2020.9   First semester

  • 歯学部4年生:歯科全身管理学

    2020.4 - 2020.9   First semester

  • 医学部6年生:衛生・公衆衛生学

    2020.4 - 2020.9   First semester

  • 医学部4年生:衛生・公衆衛生学

    2019.10 - 2020.3   Second semester

  • 総合コホートセンターを基盤とした新知見発掘の推進と国際的人材(新世代コホート研究リーダー)育成プログラム

    2019.4 - 2020.3   Full year

  • アカデミック・フロンティア

    2019.4 - 2019.9   First semester

  • 歯学部4年生:歯科全身管理学

    2019.4 - 2019.9   First semester

  • 医学専攻博士課程:医学研究特論I

    2019.4 - 2019.9   First semester

  • 医学専攻博士課程:疫学研究

    2019.4 - 2019.9   First semester

  • 医学部6年生:衛生・公衆衛生学

    2019.4 - 2019.9   First semester

  • 生命の科学A

    2019.4 - 2019.6   Spring quarter

  • 医学部4年生:衛生・公衆衛生学

    2018.10 - 2019.3   Second semester

  • 総合コホートセンターを基盤とした新知見発掘の推進と国際的人材(新世代コホート研究リーダー)育成プログラム

    2018.4 - 2019.3   Full year

  • アカデミック・フロンティア

    2018.4 - 2018.9   First semester

  • 医学専攻博士課程:疫学研究

    2018.4 - 2018.9   First semester

  • 医学部6年生:衛生・公衆衛生学

    2018.4 - 2018.9   First semester

  • 生命の科学A

    2018.4 - 2018.6   Spring quarter

  • 衛生学

    2017.10 - 2018.3   Second semester

  • 医学部4年生:衛生・公衆衛生学

    2017.10 - 2018.3   Second semester

  • 疫学研究

    2017.4 - 2017.9   First semester

  • アカデミック・フロンティア

    2017.4 - 2017.9   First semester

  • 医学部6年生:衛生・公衆衛生学

    2017.4 - 2017.9   First semester

  • 生命の科学A

    2017.4 - 2017.6   Spring quarter

  • 医学部4年生:衛生・公衆衛生学

    2016.10 - 2017.3   Second semester

  • 医学部6年生:衛生・公衆衛生学

    2016.4 - 2016.9   First semester

  • アカデミック・フロンティア

    2016.4 - 2016.9   First semester

  • 疫学研究

    2024.6 - 2024.8   Summer quarter

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FD Participation

  • 2024.9   Role:Participation   Title:令和6年度 九州大学馬出地区4部局合同男女共同参画FD・    九州大学病院きらめきプロジェクト講演会

    Organizer:University-wide

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2023  学校法人原学園 原看護専門学校  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2022  名城大学薬学部 3年生講義  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2022  令和健康科学大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2022  学校法人原学園 原看護専門学校  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2021  名城大学薬学部 3年生講義  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2021  学校法人原学園 原看護専門学校  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2021  国立研究開発法人 国立循環器病研究センター  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:2021.7.1-2024.3.31

  • 2020  名城大学薬学部 3年生講義  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2020  学校法人原学園 原看護専門学校  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2019  名城大学薬学部 3年生講義  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2019  認定NPO法人 健康医療評価研究機構(iHope International)  Classification:Affiliate faculty  Domestic/International Classification:Japan 

  • 2019  The George institute for global health, Australia  Classification:Affiliate faculty  Domestic/International Classification:Overseas 

  • 2018  認定NPO法人 健康医療評価研究機構(iHope International)  Classification:Affiliate faculty  Domestic/International Classification:Japan 

  • 2018  和歌山県立医科大学大学院特別講義兼大学院教員FD研修会  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2018  名城大学薬学部 3年生講義  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2018  国立大学法人 滋賀医科大学:博士課程教育リーディングプログラム  Classification:Part-time lecturer 

  • 2018  The George institute for global health, Australia  Classification:Affiliate faculty  Domestic/International Classification:Overseas 

▼display all

Other educational activity and Special note

  • 2021  Coaching of Students' Association  九州大学医学部熱帯医学研究会

     詳細を見る

    会長

  • 2020  Coaching of Students' Association  九州大学医学部熱帯医学研究会

     詳細を見る

    会長

  • 2019  Coaching of Students' Association  九州大学医学部熱帯医学研究会

     詳細を見る

    会長

Outline of Social Contribution and International Cooperation activities

  • 久山町の地域住民および開業医を対象とした認知症、生活習慣病全般および腎臓病疾患についての健康相談および医療相談
    他県の自治体やセミナーにおいて認知症や生活習慣病予防に関する公開講座
    福岡県およぶ福岡市と生活習慣病予防における共同事業
    The George insitute for global health (Australia)やKuakini Health system (Hawaii)などとの国際共同研究

Social Activities

  • バイエル循環器病研究助成選考委員会 委員

    公益財団法人 循環器病研究振興財団  2025.7

  • 不明

    NHK「ニュース7」  2019.5

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    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:TV or radio program

  • 血清sTREM2濃度と認知症発症の関係:久山町研究

    秋田さきがけ  2019.5

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    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Newspaper, magazine

  • 生活習慣病と認知症

    東彼杵町食生活改善推進協議会研修会  2019.4

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    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 血清sTREM2濃度と認知症発症の関係:久山町研究

    静岡新聞、沖縄タイムス  2019.4

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    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Newspaper, magazine

  • 血清sTREM2濃度と認知症発症の関係:久山町研究

    神戸新聞、茨木新聞、京都新聞、山陰新聞、福島新聞、  2019.3

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    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Newspaper, magazine

  • 多職種連携研修会「生活習慣病と認知症」

    福岡県久山町  2019.2

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    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Seminar, workshop

  • 認知症フォーラム in いよし「生活習慣病と認知症」

    愛媛県伊予市  2018.12

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    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 高齢者が摂取すべき高栄養食品としての牛乳の可能性.

    明治乳業  丸ビルホール  2016.5

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    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 「お魚で心筋梗塞にならない」 EPAが心血管病に及ぼす影響

    第12回日本糖尿病情報学会年次学術集会  千葉幕張メッセ 国際会議場  2012.7

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    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 心血管病の予防因子としてのEPA ~久山町疫学調査の結果から~

    産経新聞社  東京大手町サンケイプラザ  2012.3

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    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

▼display all

Media Coverage

  • 町民約9000人を対象.生活習慣病(脳卒中・認知症など)の疫学調査.国の認知症予防策における重要な資料に. TV or radio program

    超ハードコア教養バラエティー カズレーザーと学ぶ。  2023.11

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    町民約9000人を対象.生活習慣病(脳卒中・認知症など)の疫学調査.国の認知症予防策における重要な資料に.

  • 超有名「久山町研究」はなぜ生まれた?過去の資産を進化させ続ける久山の挑戦.久山町が世界に誇る「久山町研究」.

    JBpress NET  2023.9

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    超有名「久山町研究」はなぜ生まれた?過去の資産を進化させ続ける久山の挑戦.久山町が世界に誇る「久山町研究」.

  • 交流少ないと脳萎縮.九大など、高齢者9000人調査. Newspaper, magazine

    日本経済新聞  2023.8

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    交流少ないと脳萎縮.九大など、高齢者9000人調査.

  • 福岡県/久山の健康診断事業 河野デジタル大臣相視察 首相と福岡市も訪問. Newspaper, magazine

    西日本新聞  2023.7

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    福岡県/久山の健康診断事業 河野デジタル大臣相視察 首相と福岡市も訪問.

  • 河野デジタル大臣が久山町視察「医療のデジタル化を後押し」.

    福岡 NEWS WEB  2023.7

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    河野デジタル大臣が久山町視察「医療のデジタル化を後押し」.

  • アサデス。ポスト 牛乳関係の研究.福岡の大学教授が調査. TV or radio program

    KBCテレビ「アサデス。KBC」  2023.6

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    アサデス。ポスト 牛乳関係の研究.福岡の大学教授が調査.

  • 小6「久山町研究」絵本に.山田小疫学調査取材し制作. Newspaper, magazine

    西日本新聞 朝刊  2023.3

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    小6「久山町研究」絵本に.山田小疫学調査取材し制作.

  • 歩きたくなるまちづくり.福岡市が病気予防策.ビッグデータ一元化、活用. Newspaper, magazine

    西日本新聞  2022.4

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    歩きたくなるまちづくり.福岡市が病気予防策.ビッグデータ一元化、活用.

  • アブラのトリセツ 健康の鍵は“アブラ”のバランス. TV or radio program

    NHK 明日が変わるトリセツショー  2022.4

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    アブラのトリセツ 健康の鍵は“アブラ”のバランス.

  • シニアサポーター.食欲減退、どう対処する?.おやつの有効活用で栄養補給. Newspaper, magazine

    日本経済新聞(夕刊)  2022.3

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    シニアサポーター.食欲減退、どう対処する?.おやつの有効活用で栄養補給.

  • 要介護「喫煙」「やせ」注意      福岡市と九大リスク分析 Newspaper, magazine

    読売新聞2022.2.1(朝刊)  2022.2

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    要介護「喫煙」「やせ」注意      福岡市と九大リスク分析

  • 巻頭言. 久山町研究室~60年目を迎えて~. Newspaper, magazine

    Medical View Point 42: 1, 2021  2021.5

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    巻頭言. 久山町研究室~60年目を迎えて~.

  • フレイル予防で健康長寿.‹インタビュー›

    福岡市政だより 令和3年5月1日号, 2, 2021  2021.5

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    フレイル予防で健康長寿.‹インタビュー›

  • “日本の縮図”ともいえる、福岡県の小さな町の研究によって驚きの事実が!約60年続く大プロジェクトで握力と寿命の不思議な関係が解明!. Newspaper, magazine

    NHKガッテン 季刊化リニューアル記念号: 14-21, 2021  2021.4

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    “日本の縮図”ともいえる、福岡県の小さな町の研究によって驚きの事実が!約60年続く大プロジェクトで握力と寿命の不思議な関係が解明!.

  • 日本の健康研究“最前線”.人生を謳歌する“健康長寿”のために!.タッグを組んだ久山町研究とサントリー. Newspaper, magazine

    美感遊創 Enjoy Wellness Life 223, 15-16, 2021  2021.4

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    日本の健康研究“最前線”.人生を謳歌する“健康長寿”のために!.タッグを組んだ久山町研究とサントリー.

  • 日本の健康研究“最前線”.人生を謳歌する“健康長寿”のために!.タッグを組んだ久山町研究とサントリー. Newspaper, magazine

    サントリーウエルネスのお客様にお届けする、すこやかな暮らしへの提案 美感遊創 223, 15-16, 2021  2021.4

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    日本の健康研究“最前線”.人生を謳歌する“健康長寿”のために!.タッグを組んだ久山町研究とサントリー.

  • 紙上座談会:筋肉量コツコツ積み上げ健康長寿. Newspaper, magazine

    朝日新聞  2020.11

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    紙上座談会:筋肉量コツコツ積み上げ健康長寿.

  • 水出し緑茶で健康習慣. 1日2杯糖尿病リスク低減. Newspaper, magazine

    産経新聞  2020.8

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    水出し緑茶で健康習慣. 1日2杯糖尿病リスク低減.

  • from SCE ~日本臨床疫学会から~. 日本臨床疫学会第3回年次学術大会開催報.

    Primaria 41: 22-23  2020.4

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    from SCE ~日本臨床疫学会から~. 日本臨床疫学会第3回年次学術大会開催報.

  • 「老後を変える九州共創会議」. Newspaper, magazine

    西日本新聞  2020.2

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    「老後を変える九州共創会議」.

  • 老後を変える九州共創会議.健康管理と企業、地域の役割とは. Newspaper, magazine

    西日本新聞, 2019.12.21  2019.12

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    老後を変える九州共創会議.健康管理と企業、地域の役割とは.

  • 過剰なトランス脂肪酸.認知症リスク?九大・神戸大10年追跡調査. Newspaper, magazine

    朝日新聞, 2019.11.15  2019.11

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    過剰なトランス脂肪酸.認知症リスク?九大・神戸大10年追跡調査.

  • 認知症リスク、トランス脂肪酸接種で増大か.米誌に発表. Newspaper, magazine

    朝日新聞 DIGITAL, 2019.11.14  2019.11

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    認知症リスク、トランス脂肪酸接種で増大か.米誌に発表.

  • メディカルサイエンスドキュメンタリー BRAIN~ここまで来た!脳医学最前線~.8月6日放送

    RKB毎日放送  2019.8

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    メディカルサイエンスドキュメンタリー BRAIN~ここまで来た!脳医学最前線~.8月6日放送

  • 人生100年お茶が効く?サントリー食品、健康寿命巡り研究. Newspaper, magazine

    日経MJ(流通新聞), 2019.7.12  2019.7

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    人生100年お茶が効く?サントリー食品、健康寿命巡り研究.

  • 「伊右衛門」サービスブランド化.外食スキーム変更し顧客接点強固に. Newspaper, magazine

    食品新聞(ネット掲載), 2019.7.2  2019.7

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    「伊右衛門」サービスブランド化.外食スキーム変更し顧客接点強固に.

  • 早期発見・予防の指標に.血中物質の測定値認知症発症と関連.九州大教授ら研究. Newspaper, magazine

    秋田さきがけ, 2019.5.20  2019.5

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    早期発見・予防の指標に.血中物質の測定値認知症発症と関連.九州大教授ら研究.

  • 血中の物質が認知症と関連.九大など早期発見、予防に期待. Newspaper, magazine

    静岡新聞(夕刊), 2019.4.9  2019.4

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    血中の物質が認知症と関連.九大など早期発見、予防に期待.

  • 血中物質認知症と関連.早期発見、予防に期待. Newspaper, magazine

    山陽新聞, 2019.3.31  2019.3

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    血中物質認知症と関連.早期発見、予防に期待.

  • 認知症.血中物質も関連.九大教授ら発表.採血で早期発見期待. Newspaper, magazine

    福島民友, 2019.3.25  2019.3

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    認知症.血中物質も関連.九大教授ら発表.採血で早期発見期待.

  • 認知症.血中の物質と関連.早期発見、予防に期待. Newspaper, magazine

    茨城新聞, 2019.3.14  2019.3

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    認知症.血中の物質と関連.早期発見、予防に期待.

  • sTREM2. 血中の物質が認知症と関連. Newspaper, magazine

    京都新聞, 2019.3.19  2019.3

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    sTREM2. 血中の物質が認知症と関連.

  • 血液中の物質が認知症と関連.九州大・二宮教授ら発表、予防に期待. Newspaper, magazine

    神戸新聞, 2019.3.25  2019.3

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    血液中の物質が認知症と関連.九州大・二宮教授ら発表、予防に期待.

  • 血中特定物質認知症と関連. Newspaper, magazine

    沖縄タイムス, 2019.4.2  2019.2

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    血中特定物質認知症と関連.

  • 認知症発症リスク。血中たんぱく質指標に。九大など1300人調査、10年で2倍 Newspaper, magazine

    西日本新聞  2018.12

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    認知症発症リスク。血中たんぱく質指標に。九大など1300人調査、10年で2倍

  • 筋力を保ち生活習慣病の予防を.認知症リスクを減らすには.

    朝日新聞DIGITAL,  2018.8

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    筋力を保ち生活習慣病の予防を.認知症リスクを減らすには.

  • 認知症発症リスク.血中タンパク質指標に.九大など1300人調査、10年で2倍. Newspaper, magazine

    西日本新聞  2018.8

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    認知症発症リスク.血中タンパク質指標に.九大など1300人調査、10年で2倍.

  • 認知症予防「誰でもなる」前提に. Newspaper, magazine

    朝日新聞  2018.8

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    認知症予防「誰でもなる」前提に.

  • 認知症発症と筋力に関連.牛乳 筋肉組織の強化からも有用性. Newspaper, magazine

    産経新聞  2018.6

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    認知症発症と筋力に関連.牛乳 筋肉組織の強化からも有用性.

  • 久山町・九大・DeNA、「ひさやま元気予報」を開発.

    日本経済新聞電子版  2018.4

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    久山町・九大・DeNA、「ひさやま元気予報」を開発.

  • 糖尿病 心血管病 健診データで〝元気予報〟15年後の発症確率算出. Newspaper, magazine

    西日本新聞  2018.4

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    糖尿病 心血管病 健診データで〝元気予報〟15年後の発症確率算出.

  • 病気の発症リスクを“天気予報”のように.

    日経デジタルヘルス  2018.4

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    病気の発症リスクを“天気予報”のように.

  • 健康リスク、天気マークで一目 久山町・九大など、「元気予報」開発/福岡県. Newspaper, magazine

    朝日新聞  2018.4

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    健康リスク、天気マークで一目 久山町・九大など、「元気予報」開発/福岡県.

  • 「久山町研究」の成果に基づき「ひさやま元気予報」を開発.ICTを活用して疾患の発症に関する情報提供、健康増進への取り組みを開始.

    DeSC Healthcare web  2018.4

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    「久山町研究」の成果に基づき「ひさやま元気予報」を開発.ICTを活用して疾患の発症に関する情報提供、健康増進への取り組みを開始.

  • 福岡県久山町、健康増進に向け疾患の発症に関する「ひさやま天気予報」を提供へ.

    DIGITAL X,  2018.4

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    福岡県久山町、健康増進に向け疾患の発症に関する「ひさやま天気予報」を提供へ.

  • 九大グループ.血液認知症リスク指標に.血糖値変動幅から判定. Newspaper, magazine

    西日本新聞  2018.1

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    九大グループ.血液認知症リスク指標に.血糖値変動幅から判定.

  • 若年時の学校教育認知症予防に効果か.欧米患者の割合減少. Newspaper, magazine

    朝日新聞  2018.1

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    若年時の学校教育認知症予防に効果か.欧米患者の割合減少.

  • 認知症予防に挑む3/5.糖尿病防ぎリスク減らす. Newspaper, magazine

    読売新聞  2017.11

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    認知症予防に挑む3/5.糖尿病防ぎリスク減らす.

  • 疫学調査で予防に活路.生活習慣改善、リスク抑制. Newspaper, magazine

    日本経済新聞  2017.7

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    疫学調査で予防に活路.生活習慣改善、リスク抑制.

  • 九州大研究チームが発表.糖尿病患者認知症に注意. Newspaper, magazine

    北海道新聞  2017.5

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    九州大研究チームが発表.糖尿病患者認知症に注意.

  • 第7回高齢者の健康づくり・介護予防ー健康長寿延伸のカギー。糖尿病の実態と予防法 Newspaper, magazine

    健康づくり462、12-15、2016  2016.10

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    第7回高齢者の健康づくり・介護予防ー健康長寿延伸のカギー。糖尿病の実態と予防法

  • 糖尿病・中年期の高血圧リスク Newspaper, magazine

    日本経済新聞  2016.10

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    糖尿病・中年期の高血圧リスク

  • 高齢者に広がる低栄養。認知症発症とも関係。 Newspaper, magazine

    MAGNET 45:17,2016  2016.9

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    高齢者に広がる低栄養。認知症発症とも関係。

  • 高齢者の低栄養問題 その予防と有効な対策ー食事と認知症に関係性

    産経ニュース  2016.3

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    高齢者の低栄養問題 その予防と有効な対策ー食事と認知症に関係性

  • 認知症リスク 高まる可能性 Newspaper, magazine

    朝日新聞  2016.2

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    認知症リスク 高まる可能性

  • あのときそれから.認知症介護「告発の書」. Newspaper, magazine

    朝日新聞夕刊  2015.11

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    あのときそれから.認知症介護「告発の書」.

  • 牛乳「認知症予防に効果」.「毎日摂取」発症率4割低く. Newspaper, magazine

    西日本新聞  2015.10

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    牛乳「認知症予防に効果」.「毎日摂取」発症率4割低く.

  • 認知症 生活習慣で防げ.糖尿病や高血圧、リスク高く. Newspaper, magazine

    日本経済新聞夕刊  2015.5

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    認知症 生活習慣で防げ.糖尿病や高血圧、リスク高く.

  • 尿酸値の高値がCKD発症に関係.久山町の疫学調査で明らかに.

    日刊薬業  2015.2

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    尿酸値の高値がCKD発症に関係.久山町の疫学調査で明らかに.

  • 人生の楽譜.徘徊30キロ…壮絶な現実. Newspaper, magazine

    産経新聞  2015.2

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    人生の楽譜.徘徊30キロ…壮絶な現実.

  • 慢性腎臓病発症尿酸値が関連. Newspaper, magazine

    日刊工業新聞  2015.2

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    慢性腎臓病発症尿酸値が関連.

  • 福岡市で予防フォーラム.「野菜、乳製品、運動で認知症防げる」. Newspaper, magazine

    西日本新聞, 2015.1.22  2015.1

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    福岡市で予防フォーラム.「野菜、乳製品、運動で認知症防げる」.

  • 認知症10年後700万人(福岡県久山町の住民を対象にした、長期間の追跡調査を基に厚生省の研究班がまとめた推計の掲載) Newspaper, magazine

    西日本新聞  2015.1

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    認知症10年後700万人(福岡県久山町の住民を対象にした、長期間の追跡調査を基に厚生省の研究班がまとめた推計の掲載)

  • 慢性腎臓病(CKD)~早期発見とその管理の重要性~ Newspaper, magazine

    朝日新聞  2014.10

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    慢性腎臓病(CKD)~早期発見とその管理の重要性~

  • 慢性腎臓病の時代的変化 慢性腎臓病とメタボリックシンドロームの関係

    m3.com  2010.9

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    慢性腎臓病の時代的変化
    慢性腎臓病とメタボリックシンドロームの関係

  • CKDは心血管心血管疾患,心筋梗塞,全死亡の危険因子 二宮利治氏に聞く: 今後のテーマは,治療をどうするか

    epi-c.jp  2009.6

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    CKDは心血管心血管疾患,心筋梗塞,全死亡の危険因子
    二宮利治氏に聞く: 今後のテーマは,治療をどうするか

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Activities contributing to policy formation, academic promotion, etc.

  • 2018.4 - 2021.3   福岡市保健福祉局政策推進部政策推進課

    福岡市保健福祉審議会委員

  • 2018.4 - 2019.3   国立研究開発法人 日本医療研究開発機構

    医療研究開発革新基盤創成事業【CiCLE】専門委員

  • 2018.4 - 2018.3   特定非営利活動法人 健康医療評価研究機構

    学術諮問委員

  • 2017.4 - 2019.3   福岡県すこやか健康事業団

    生活習慣病専門部会委員

  • 2017.4 - 2018.3   特定非営利活動法人 健康医療評価研究機構

    学術諮問委員

  • 2016.1 - 2016.9   国立研究開発法人日本医療研究開発機構

    医療分野研究成果展開事業 産学連携医療イノベーション創出プログラム 課題評価委員(書面評価)
    ACT-M

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Travel Abroad

  • 2013.8 - 2014.4

    Staying countory name 1:Australia   Staying institution name 1:The George institute for global health

  • 2013.3

    Staying countory name 1:Netherlands   Staying institution name 1:Dept. Clinical Pharmacology, University Medical Center Groningen

  • 2006.10 - 2009.9

    Staying countory name 1:Australia   Staying institution name 1:The George Institute for International Health, University of Sydney

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Nephrology

Clinician qualification

  • Specialist

    Japanese Society of Nephrology(JSN)

  • Specialist

    The Japanese Society of Internal Medicine(JSIM)

Year of medical license acquisition

  • 1993

Notable Clinical Activities

  • 福岡市や久山町における地域住民を対象とした健康啓発活動