2024/08/26 更新

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写真a

アタラシ　コウジ
新 幸二
ATARASHI KOJI
所属
医学研究院 基礎医学部門 教授
医学部 医学科（併任）
医学系学府 医学専攻（併任）
医学系学府 医科学専攻（併任）
職名
教授
外部リンク

研究分野

  • ライフサイエンス / 細菌学

  • ライフサイエンス / 免疫学

経歴

  • 九州大学   大学院医学研究院   教授

    2024年4月 - 現在

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  • 慶應義塾大学医学部   准教授

    2017年2月 - 2024年3月

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研究テーマ・研究キーワード

  • 研究テーマ：腸内細菌

    研究キーワード：腸内細菌

    研究期間： 2024年

  • 研究テーマ：粘膜免疫

    研究キーワード：粘膜免疫

    研究期間： 2024年

論文

  • Periportal macrophages protect against commensal-driven liver inflammation. 国際誌

    Yu Miyamoto, Junichi Kikuta, Takahiro Matsui, Tetsuo Hasegawa, Kentaro Fujii, Daisuke Okuzaki, Yu-Chen Liu, Takuya Yoshioka, Shigeto Seno, Daisuke Motooka, Yutaka Uchida, Erika Yamashita, Shogo Kobayashi, Hidetoshi Eguchi, Eiichi Morii, Karl Tryggvason, Takashi Shichita, Hisako Kayama, Koji Atarashi, Jun Kunisawa, Kenya Honda, Kiyoshi Takeda, Masaru Ishii

    Nature   2024年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    The liver is the main gateway from the gut, and the unidirectional sinusoidal flow from portal to central veins constitutes heterogenous zones, including the periportal vein (PV) and the pericentral vein zones1-5. However, functional differences in the immune system in each zone remain poorly understood. Here intravital imaging revealed that inflammatory responses are suppressed in PV zones. Zone-specific single-cell transcriptomics detected a subset of immunosuppressive macrophages enriched in PV zones that express high levels of interleukin-10 and Marco, a scavenger receptor that sequesters pro-inflammatory pathogen-associated molecular patterns and damage-associated molecular patterns, and consequently suppress immune responses. Induction of Marco+ immunosuppressive macrophages depended on gut microbiota. In particular, a specific bacterial family, Odoribacteraceae, was identified to induce this macrophage subset through its postbiotic isoallolithocholic acid. Intestinal barrier leakage resulted in inflammation in PV zones, which was markedly augmented in Marco-deficient conditions. Chronic liver inflammatory diseases such as primary sclerosing cholangitis (PSC) and non-alcoholic steatohepatitis (NASH) showed decreased numbers of Marco+ macrophages. Functional ablation of Marco+ macrophages led to PSC-like inflammatory phenotypes related to colitis and exacerbated steatosis in NASH in animal experimental models. Collectively, commensal bacteria induce Marco+ immunosuppressive macrophages, which consequently limit excessive inflammation at the gateway of the liver. Failure of this self-limiting system promotes hepatic inflammatory disorders such as PSC and NASH.

    DOI： 10.1038/s41586-024-07372-6

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  • Rationally-defined microbial consortia suppress multidrug-resistant proinflammatory Enterobacteriaceae via ecological control. 国際誌

    Kenya Honda, Munehiro Furuichi, Takaaki Kawaguchi, Marie-Madlen Pust, Keiko Yasuma-Mitobe, Damian Plichta, Naomi Hasegawa, Takashi Ohya, Shakti Bhattarai, Satoshi Sasajima, Aoto Yoshimasa, Timur Tuganbaev, Mizuki Yaginuma, Masahiro Ueda, Nobuyuki Okahashi, Kimiko Amafuji, Yuuko Kiridooshi, Kayoko Sugita, Martin Stražar, Ashwin Skelly, Wataru Suda, Masahira Hattori, Nobuhiro Nakamoto, Silvia Caballero, Jason Norman, Bernat Olle, Takeshi Tanoue, Makoto Arita, Vanni Bucci, Koji Atarashi, Ramnik Xavier

    Research square   2023年10月

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    記述言語：英語  

    Persistent colonization and outgrowth of pathogenic organisms in the intestine may occur due to long-term antibiotic usage or inflammatory conditions, which perpetuate dysregulated immunity and tissue damage1,2. Gram-negative Enterobacteriaceae gut pathobionts are particularly recalcitrant to conventional antibiotic treatment3,4, though an emerging body of evidence suggests that manipulation of the commensal microbiota may be a practical alternative therapeutic strategy5-7. In this study, we rationally isolated and down-selected commensal bacterial consortia from healthy human stool samples capable of strongly and specifically suppressing intestinal Enterobacteriaceae. One of the elaborated consortia, consisting of 18 commensal strains, effectively controlled ecological niches by regulating gluconate availability, thereby reestablishing colonization resistance and alleviating antibiotic-resistant Klebsiella-driven intestinal inflammation in mice. Harnessing these microbial activities in the form of live bacterial therapeutics may represent a promising solution to combat the growing threat of proinflammatory, antimicrobial-resistant bacterial infection.

    DOI： 10.21203/rs.3.rs-3462622/v1

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  • Centenarians have a diverse gut virome with the potential to modulate metabolism and promote healthy lifespan. 国際誌

    Joachim Johansen, Koji Atarashi, Yasumichi Arai, Nobuyoshi Hirose, Søren J Sørensen, Tommi Vatanen, Mikael Knip, Kenya Honda, Ramnik J Xavier, Simon Rasmussen, Damian R Plichta

    Nature microbiology   8 ( 6 )   1064 - 1078   2023年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Distinct gut microbiome ecology may be implicated in the prevention of aging-related diseases as it influences systemic immune function and resistance to infections. Yet, the viral component of the microbiome throughout different stages in life remains unexplored. Here we present a characterization of the centenarian gut virome using previously published metagenomes from 195 individuals from Japan and Sardinia. Compared with gut viromes of younger adults (>18 yr) and older individuals (>60 yr), centenarians had a more diverse virome including previously undescribed viral genera, such as viruses associated with Clostridia. A population shift towards higher lytic activity was also observed. Finally, we investigated phage-encoded auxiliary functions that influence bacterial physiology, which revealed an enrichment of genes supporting key steps in sulfate metabolic pathways. Phage and bacterial members of the centenarian microbiome displayed an increased potential for converting methionine to homocysteine, sulfate to sulfide and taurine to sulfide. A greater metabolic output of microbial hydrogen sulfide in centenarians may in turn support mucosal integrity and resistance to pathobionts.

    DOI： 10.1038/s41564-023-01370-6

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  • Diet-mediated constitutive induction of novel IL-4+ ILC2 cells maintains intestinal homeostasis in mice 国際誌

    Wanlin Cui, Yuji Nagano, Satoru Morita, Takeshi Tanoue, Hidehiro Yamane, Keiko Ishikawa, Toshiro Sato, Masato Kubo, Shohei Hori, Tadatsugu Taniguchi, Masanori Hatakeyama, Koji Atarashi, Kenya Honda

    Journal of Experimental Medicine   220 ( 8 )   2023年5月   （ ISSN:0022-1007 eISSN:1540-9538 ）

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Rockefeller University Press  

    Group 2 innate lymphoid cells (ILC2s) expressing IL-5 and IL-13 are localized at various mucosal tissues and play critical roles in the induction of type 2 inflammation, response to helminth infection, and tissue repair. Here, we reveal a unique ILC2 subset in the mouse intestine that constitutively expresses IL-4 together with GATA3, ST2, KLRG1, IL-17RB, and IL-5. In this subset, IL-4 expression is regulated by mechanisms similar to but distinct from those observed in T cells and is partly affected by IL-25 signaling. Although the absence of the microbiota had marginal effects, feeding mice with a vitamin B1-deficient diet compromised the number of intestinal IL-4+ ILC2s. The decrease in the number of IL-4+ ILC2s caused by the vitamin B1 deficiency was accompanied by a reduction in IL-25–producing tuft cells. Our findings reveal that dietary vitamin B1 plays a critical role in maintaining interaction between tuft cells and IL-4+ ILC2s, a previously uncharacterized immune cell population that may contribute to maintaining intestinal homeostasis.

    DOI： 10.1084/jem.20221773

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  • An old model with new insights: endogenous retroviruses drive the evolvement toward ASD susceptibility and hijack transcription machinery during development. 国際誌

    Chia-Wen Lin, Jacob Ellegood, Kota Tamada, Ikuo Miura, Mikiko Konda, Kozue Takeshita, Koji Atarashi, Jason P Lerch, Shigeharu Wakana, Thomas J McHugh, Toru Takumi

    Molecular psychiatry   28 ( 5 )   1932 - 1945   2023年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    The BTBR T+Itpr3tf/J (BTBR/J) strain is one of the most valid models of idiopathic autism, serving as a potent forward genetics tool to dissect the complexity of autism. We found that a sister strain with an intact corpus callosum, BTBR TF/ArtRbrc (BTBR/R), showed more prominent autism core symptoms but moderate ultrasonic communication/normal hippocampus-dependent memory, which may mimic autism in the high functioning spectrum. Intriguingly, disturbed epigenetic silencing mechanism leads to hyperactive endogenous retrovirus (ERV), a mobile genetic element of ancient retroviral infection, which increases de novo copy number variation (CNV) formation in the two BTBR strains. This feature makes the BTBR strain a still evolving multiple-loci model toward higher ASD susceptibility. Furthermore, active ERV, analogous to virus infection, evades the integrated stress response (ISR) of host defense and hijacks the transcriptional machinery during embryonic development in the BTBR strains. These results suggest dual roles of ERV in the pathogenesis of ASD, driving host genome evolution at a long-term scale and managing cellular pathways in response to viral infection, which has immediate effects on embryonic development. The wild-type Draxin expression in BTBR/R also makes this substrain a more precise model to investigate the core etiology of autism without the interference of impaired forebrain bundles as in BTBR/J.

    DOI： 10.1038/s41380-023-01999-z

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  • Myeloid-like B cells boost emergency myelopoiesis through IL-10 production during infection 国際誌

    Masashi Kanayama, Yuta Izumi, Megumi Akiyama, Toyoki Hayashi, Koji Atarashi, Axel Roers, Taku Sato, Toshiaki Ohteki

    Journal of Experimental Medicine   220 ( 4 )   2023年1月   （ ISSN:0022-1007 eISSN:1540-9538 ）

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Rockefeller University Press  

    Emergency myelopoiesis (EM) is a hematopoietic response against systemic infections that quickly supplies innate immune cells. As lymphopoiesis is strongly suppressed during EM, the role of lymphocytes in that process has not received much attention. Here, we found that myeloid-like B cells (M-B cells), which express myeloid markers, emerge in the bone marrow (BM) after the induction of EM. M-B cells were mainly derived from pre-B cells and preferentially expressed IL-10, which directly stimulates hematopoietic progenitors to enhance their survival and myeloid-biased differentiation. Indeed, lacking IL-10 in B cells, blocking IL-10 in the BM with a neutralizing antibody, and deleting the IL-10 receptor in hematopoietic progenitors significantly suppressed EM, which failed to clear microbes in a cecal ligation and puncture model. Thus, a distinct B cell subset generated during infection plays a pivotal role in boosting EM, which suggests the on-demand reinforcement of EM by adaptive immune cells.

    DOI： 10.1084/jem.20221221

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  • D-amino Acids Ameliorate Experimental Colitis and Cholangitis by Inhibiting Growth of Proteobacteria: Potential Therapeutic Role in Inflammatory Bowel Disease. 国際誌

    Satoko Umeda, Tomohisa Sujino, Kentaro Miyamoto, Yusuke Yoshimatsu, Yosuke Harada, Keita Nishiyama, Yoshimasa Aoto, Keika Adachi, Naoki Hayashi, Kimiko Amafuji, Nobuko Moritoki, Shinsuke Shibata, Nobuo Sasaki, Masashi Mita, Shun Tanemoto, Keiko Ono, Yohei Mikami, Jumpei Sasabe, Kaoru Takabayashi, Naoki Hosoe, Toshihiko Suzuki, Toshiro Sato, Koji Atarashi, Toshiaki Teratani, Haruhiko Ogata, Nobuhiro Nakamoto, Daisuke Shiomi, Hiroshi Ashida, Takanori Kanai

    Cellular and molecular gastroenterology and hepatology   16 ( 6 )   1011 - 1031   2023年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND & AIMS: D-amino acids, the chiral counterparts of protein L-amino acids, were primarily produced and utilized by microbes, including those in the human gut. However, little was known about how orally administered or microbe-derived D-amino acids affected the gut microbial community or gut disease progression. METHODS: The ratio of D- to L-amino acids was analyzed in feces and blood from patients with ulcerative colitis (UC) and healthy controls. Also, composition of microbe was analyzed from patients with UC. Mice were treated with D-amino acid in dextran sulfate sodium colitis model and liver cholangitis model. RESULTS: The ratio of D- to L-amino acids was lower in the feces of patients with UC than that of healthy controls. Supplementation of D-amino acids ameliorated UC-related experimental colitis and liver cholangitis by inhibiting growth of Proteobacteria. Addition of D-alanine, a major building block for bacterial cell wall formation, to culture medium inhibited expression of the ftsZ gene required for cell fission in the Proteobacteria Escherichia coli and Klebsiella pneumoniae, thereby inhibiting growth. Overexpression of ftsZ restored growth of E. coli even when D-alanine was present. We found that D-alanine not only inhibited invasion of pathological K. pneumoniae into the host via pore formation in intestinal epithelial cells but also inhibited growth of E. coli and generation of antibiotic-resistant strains. CONCLUSIONS: D-amino acids might have potential for use in novel therapeutic approaches targeting Proteobacteria-associated dysbiosis and antibiotic-resistant bacterial diseases by means of their effects on the intestinal microbiota community.

    DOI： 10.1016/j.jcmgh.2023.08.002

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  • Microbiota imbalance induced by dietary sugar disrupts immune-mediated protection from metabolic syndrome. 国際誌

    Yoshinaga Kawano, Madeline Edwards, Yiming Huang, Angelina M Bilate, Leandro P Araujo, Takeshi Tanoue, Koji Atarashi, Mark S Ladinsky, Steven L Reiner, Harris H Wang, Daniel Mucida, Kenya Honda, Ivaylo I Ivanov

    Cell   185 ( 19 )   3501 - 3519   2022年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    How intestinal microbes regulate metabolic syndrome is incompletely understood. We show that intestinal microbiota protects against development of obesity, metabolic syndrome, and pre-diabetic phenotypes by inducing commensal-specific Th17 cells. High-fat, high-sugar diet promoted metabolic disease by depleting Th17-inducing microbes, and recovery of commensal Th17 cells restored protection. Microbiota-induced Th17 cells afforded protection by regulating lipid absorption across intestinal epithelium in an IL-17-dependent manner. Diet-induced loss of protective Th17 cells was mediated by the presence of sugar. Eliminating sugar from high-fat diets protected mice from obesity and metabolic syndrome in a manner dependent on commensal-specific Th17 cells. Sugar and ILC3 promoted outgrowth of Faecalibaculum rodentium that displaced Th17-inducing microbiota. These results define dietary and microbiota factors posing risk for metabolic syndrome. They also define a microbiota-dependent mechanism for immuno-pathogenicity of dietary sugar and highlight an elaborate interaction between diet, microbiota, and intestinal immunity in regulation of metabolic disorders.

    DOI： 10.1016/j.cell.2022.08.005

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  • Identification of trypsin-degrading commensals in the large intestine. 国際誌

    Youxian Li, Eiichiro Watanabe, Yusuke Kawashima, Damian R Plichta, Zhujun Wang, Makoto Ujike, Qi Yan Ang, Runrun Wu, Munehiro Furuichi, Kozue Takeshita, Koji Yoshida, Keita Nishiyama, Sean M Kearney, Wataru Suda, Masahira Hattori, Satoshi Sasajima, Takahiro Matsunaga, Xiaoxi Zhang, Kazuto Watanabe, Jun Fujishiro, Jason M Norman, Bernat Olle, Shutoku Matsuyama, Ho Namkoong, Yoshifumi Uwamino, Makoto Ishii, Koichi Fukunaga, Naoki Hasegawa, Osamu Ohara, Ramnik J Xavier, Koji Atarashi, Kenya Honda

    Nature   609 ( 7927 )   582 - 589   2022年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Increased levels of proteases, such as trypsin, in the distal intestine have been implicated in intestinal pathological conditions1-3. However, the players and mechanisms that underlie protease regulation in the intestinal lumen have remained unclear. Here we show that Paraprevotella strains isolated from the faecal microbiome of healthy human donors are potent trypsin-degrading commensals. Mechanistically, Paraprevotella recruit trypsin to the bacterial surface through type IX secretion system-dependent polysaccharide-anchoring proteins to promote trypsin autolysis. Paraprevotella colonization protects IgA from trypsin degradation and enhances the effectiveness of oral vaccines against Citrobacter rodentium. Moreover, Paraprevotella colonization inhibits lethal infection with murine hepatitis virus-2, a mouse coronavirus that is dependent on trypsin and trypsin-like proteases for entry into host cells4,5. Consistently, carriage of putative genes involved in trypsin degradation in the gut microbiome was associated with reduced severity of diarrhoea in patients with SARS-CoV-2 infection. Thus, trypsin-degrading commensal colonization may contribute to the maintenance of intestinal homeostasis and protection from pathogen infection.

    DOI： 10.1038/s41586-022-05181-3

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  • Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation. 国際誌

    Federici S, Kredo-Russo S, Valdés-Mas R, Kviatcovsky D, Weinstock E, Matiuhin Y, Silberberg Y, Atarashi K, Furuichi M, Oka A, Liu B, Fibelman M, Weiner IN, Khabra E, Cullin N, Ben-Yishai N, Inbar D, Ben-David H, Nicenboim J, Kowalsman N, Lieb W, Kario E, Cohen T, Geffen YF, Zelcbuch L, Cohen A, Rappo U, Gahali-Sass I, Golembo M, Lev V, Dori-Bachash M, Shapiro H, Moresi C, Cuevas-Sierra A, Mohapatra G, Kern L, Zheng D, Nobs SP, Suez J, Stettner N, Harmelin A, Zak N, Puttagunta S, Bassan M, Honda K, Sokol H, Bang C, Franke A, Schramm C, Maharshak N, Sartor RB, Sorek R, Elinav E

    Cell   185 ( 16 )   2879 - 2898.e24   2022年8月   （ ISSN:0092-8674 ）

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.cell.2022.07.003

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  • A common epigenetic mechanism across different cellular origins underlies systemic immune dysregulation in an idiopathic autism mouse model 国際誌

    Chia-Wen Lin, Dian E. Septyaningtrias, Hsu-Wen Chao, Mikiko Konda, Koji Atarashi, Kozue Takeshita, Kota Tamada, Jun Nomura, Yohei Sasagawa, Kaori Tanaka, Itoshi Nikaido, Kenya Honda, Thomas J. McHugh, Toru Takumi

    MOLECULAR PSYCHIATRY   27 ( 8 )   3343 - 3354   2022年5月   （ ISSN:1359-4184 eISSN:1476-5578 ）

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    記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGERNATURE  

    Immune dysregulation plays a key role in the pathogenesis of autism. Changes occurring at the systemic level, from brain inflammation to disturbed innate/adaptive immune in the periphery, are frequently observed in patients with autism; however, the intrinsic mechanisms behind them remain elusive. We hypothesize a common etiology may lie in progenitors of different types underlying widespread immune dysregulation. By single-cell RNA sequencing (sc-RNA seq), we trace the developmental origins of immune dysregulation in a mouse model of idiopathic autism. It is found that both in aorta-gonad-mesonephros (AGM) and yolk sac (YS) progenitors, the dysregulation of HDAC1-mediated epigenetic machinery alters definitive hematopoiesis during embryogenesis and downregulates the expression of the AP-1 complex for microglia development. Subsequently, these changes result in the dysregulation of the immune system, leading to gut dysbiosis and hyperactive microglia in the brain. We further confirm that dysregulated immune profiles are associated with specific microbiota composition, which may serve as a biomarker to identify autism of immune-dysregulated subtypes. Our findings elucidate a shared mechanism for the origin of immune dysregulation from the brain to the gut in autism and provide new insight to dissecting the heterogeneity of autism, as well as the therapeutic potential of targeting immune-dysregulated autism subtypes.

    DOI： 10.1038/s41380-022-01566-y

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  • Microbiota and cancer development

    Kenya Honda, Takahiro Matsunaga, Takeshi Tanoue, Koji Atarashi, Yuko Sato

    CANCER SCIENCE   113   714 - 714   2022年2月

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    記述言語：英語  

  • Microbiota and cancer development

    Kenya Honda, Takahiro Matsunaga, Takeshi Tanoue, Koji Atarashi, Yuko Sato

    CANCER SCIENCE   113   714 - 714   2022年2月   （ ISSN:1347-9032 eISSN:1349-7006 ）

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    記述言語：英語   出版者・発行元：WILEY  

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  • Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians. 国際誌

    Yuko Sato, Koji Atarashi, Damian R Plichta, Yasumichi Arai, Satoshi Sasajima, Sean M Kearney, Wataru Suda, Kozue Takeshita, Takahiro Sasaki, Shoki Okamoto, Ashwin N Skelly, Yuki Okamura, Hera Vlamakis, Youxian Li, Takeshi Tanoue, Hajime Takei, Hiroshi Nittono, Seiko Narushima, Junichiro Irie, Hiroshi Itoh, Kyoji Moriya, Yuki Sugiura, Makoto Suematsu, Nobuko Moritoki, Shinsuke Shibata, Dan R Littman, Michael A Fischbach, Yoshifumi Uwamino, Takashi Inoue, Akira Honda, Masahira Hattori, Tsuyoshi Murai, Ramnik J Xavier, Nobuyoshi Hirose, Kenya Honda

    Nature   599 ( 7885 )   458 - +   2021年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/s41586-021-03832-5

  • Low diversity of gut microbiota in the early phase of post-bone marrow transplantation increases the risk of chronic graft-versus-host disease

    Tatsuya Konishi, Shinsuke Kusakabe, Akihisa Hino, Kyoko Inamoto, Kota Yoshifuji, Yuko Kiridoshi, Kozue Takeshita, Satoshi Sasajima, Takashi Toya, Aiko Igarashi, Yuho Najima, Takeshi Kobayashi, Noriko Doki, Daisuke Motooka, Shota Nakamura, Masahiro Suyama, Wataru Suda, Atsushi Shiota, Koji Atarashi, Masahira Hattori, Kenya Honda, Takafumi Yokota, Kazuteru Ohashi, Hirohiko Shibayama, Kentaro Fukushima, Kazuhiko Kakihana

    Bone Marrow Transplantation   56 ( 7 )   1728 - 1731   2021年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/s41409-021-01249-2

  • Staphylococcus cohnii is a potentially biotherapeutic skin commensal alleviating skin inflammation. 国際誌

    Yoshihiro Ito, Takashi Sasaki, Youxian Li, Takeshi Tanoue, Yuki Sugiura, Ashwin N Skelly, Wataru Suda, Yusuke Kawashima, Nobuyuki Okahashi, Eiichiro Watanabe, Hiroto Horikawa, Aiko Shiohama, Rina Kurokawa, Eiryo Kawakami, Hachiro Iseki, Hiroshi Kawasaki, Yoichiro Iwakura, Atsushi Shiota, Liansheng Yu, Junzo Hisatsune, Haruhiko Koseki, Motoyuki Sugai, Makoto Arita, Osamu Ohara, Takeshi Matsui, Makoto Suematsu, Masahira Hattori, Koji Atarashi, Masayuki Amagai, Kenya Honda

    Cell reports   35 ( 4 )   109052 - 109052   2021年4月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.celrep.2021.109052

  • Low diversity of gut microbiota in the early phase of post-bone marrow transplantation increases the risk of chronic graft-versus-host disease. 国際誌

    Tatsuya Konishi, Shinsuke Kusakabe, Akihisa Hino, Kyoko Inamoto, Kota Yoshifuji, Yuko Kiridoshi, Kozue Takeshita, Satoshi Sasajima, Takashi Toya, Aiko Igarashi, Yuho Najima, Takeshi Kobayashi, Noriko Doki, Daisuke Motooka, Shota Nakamura, Masahiro Suyama, Wataru Suda, Atsushi Shiota, Koji Atarashi, Masahira Hattori, Kenya Honda, Takafumi Yokota, Kazuteru Ohashi, Hirohiko Shibayama, Kentaro Fukushima, Kazuhiko Kakihana

    Bone marrow transplantation   56 ( 7 )   1728 - 1731   2021年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/s41409-021-01249-2

  • Identification of unique bile acid-metabolizing bacteria from the microbiome of centenarians

    Kenya Honda, Yuko Sato, Koji Atarashi, Damian Plichta, Yasumichi Arai, Satoshi Sasajima, Sean Kearney, Wataru Suda, Kozue Takeshita, Takahiro Sasaki, Shoki Okamoto, Ashwin Skelly, Yuki Okamura, Hera Vlamakis, Youxian Li, Takeshi Tanoue, Hajime Takei, Hiroshi Nittono, Seiko Narushima, Junichiro Irie, Hiroshi Itoh, Kyoji Moriya, Yuki Sugiura, Makoto Suematsu, Nobuko Moritoki, Shinsuke Shibata, Dan Littman, Michael Fischbach, Masahira Hattori, Tsuyoshi Murai, Ramnik Xavier, Nobuyoshi Hirose

    2020年12月

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    記述言語：その他  

    DOI： 10.21203/rs.3.rs-115113/v1

  • Prebiotics protect against acute graft-versus-host disease and preserve the gut microbiota in stem cell transplantation. 国際誌

    Kota Yoshifuji, Kyoko Inamoto, Yuko Kiridoshi, Kozue Takeshita, Satoshi Sasajima, Yukiko Shiraishi, Yuko Yamashita, Yuko Nisaka, Yukari Ogura, Rie Takeuchi, Takashi Toya, Aiko Igarashi, Yuho Najima, Noriko Doki, Takeshi Kobayashi, Kazuteru Ohashi, Wataru Suda, Koji Atarashi, Atsushi Shiota, Masahira Hattori, Kenya Honda, Kazuhiko Kakihana

    Blood advances   4 ( 19 )   4607 - 4617   2020年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1182/bloodadvances.2020002604

  • TH1 cell-inducing Escherichia coli strain identified from the small intestinal mucosa of patients with Crohn's disease. 査読 国際誌

    Manabu Nagayama, Tomonori Yano, Koji Atarashi, Takeshi Tanoue, Mariko Sekiya, Yasutoshi Kobayashi, Hirotsugu Sakamoto, Kouichi Miura, Keijiro Sunada, Takaaki Kawaguchi, Satoru Morita, Kayoko Sugita, Seiko Narushima, Nicolas Barnich, Jun Isayama, Yuko Kiridooshi, Atsushi Shiota, Wataru Suda, Masahira Hattori, Hironori Yamamoto, Kenya Honda

    Gut microbes   12 ( 1 )   1 - 14   2020年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1080/19490976.2020.1788898

  • Association of Gut Microbiota with Spontaneous Autoimmune Uveitis Studied by Human Flora Reconstitution of Germ-free Mice

    Amy Zhang, Reiko Horai, Ryan S. Salvador, Colm O'hUigin, Jonathan Badger, Wuxing Yuan, Vishal Thovarai, Katsuko Sudo, Koji Atarashi, Kenya Honda, Rachel Caspi

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   61 ( 7 )   2020年6月

    　詳細を見る

    記述言語：英語  

  • USE OF A TARGETED BACTERIOPHAGE COCKTAIL FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASES

    Yulia Matiuhin, Eyal Weinstock, Efrat Khabra, Akihiko Oka, Bo Liu, Jeremy Herzog, Koji Atarashi, Munehiro Furuichi, Naomi Fliss Isakov, Morin Fibelman, Hava Ben David, Yael Silberberg, Hadar Reichman, Myriam Golembo, Sailaja Puttagunta, Harry Sokol, Nitsan Maharshak, Kenya Honda, R. Balfour Sartor, Naomi Zak

    GASTROENTEROLOGY   158 ( 6 )   S2 - S2   2020年5月

    　詳細を見る

    記述言語：英語  

  • Association of gut microbiota with spontaneous autoimmune uveitis studied by human flora reconstitution of germ-free mice

    Amy Zhang, Reiko Horai, Ryan S. Salvador, Colm O'hUigin, Jonathan Badger, Wuxing Yuan, Vishal Thovarai, Katsuko Sudo, Koji Atarashi, Kenya Honda, Rachel R. Caspi

    JOURNAL OF IMMUNOLOGY   204 ( 1 )   2020年5月

    　詳細を見る

    記述言語：英語  

  • HUMAN-DERIVED CLOSTRIDIUM VE202 STRAINS REDUCE ENTEROBACTERIACEAE AND FUSOBACTERIA AND REVERSE EXPERIMENTAL COLITIS INDUCED BY HUMAN GUT MICROBIOTA

    Akihiko Oka, Yoshiyuki Mishima, Gerold Bongers, Andrew Baltus, Jeremy Herzog, Bo Liu, Toshifumi Ohkusa, Koji Atarashi, Kenya Honda, Lani San Mateo, Scott Plevy, R. Balfour Sartor

    GASTROENTEROLOGY   158 ( 6 )   S474 - S474   2020年5月

    　詳細を見る

    記述言語：英語  

  • Endogenous murine microbiota member Faecalibaculum rodentium and its human homologue protect from intestinal tumour growth. 査読 国際誌

    Elena Zagato, Chiara Pozzi, Alice Bertocchi, Tiziana Schioppa, Fabiana Saccheri, Silvia Guglietta, Bruno Fosso, Laura Melocchi, Giulia Nizzoli, Jacopo Troisi, Marinella Marzano, Bianca Oresta, Ilaria Spadoni, Koji Atarashi, Sara Carloni, Stefania Arioli, Giulia Fornasa, Francesco Asnicar, Nicola Segata, Simone Guglielmetti, Kenya Honda, Graziano Pesole, William Vermi, Giuseppe Penna, Maria Rescigno

    Nature microbiology   5 ( 3 )   511 - 524   2020年3月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/s41564-019-0649-5

  • HUMAN-DERIVED CLOSTRIDIUM VE202 STRAINS REDUCE ENTEROBACTERIACEAE AND FUSOBACTERIA AND REVERSE EXPERIMENTAL COLITIS INDUCED BY HUMAN GUT MICROBIOTA

    Akihiko Oka, Yoshiyuki Mishima, Gerold Bongers, Andrew Baltus, Bo Liu, Jeremy Herzog, Toshifumi Ohkusa, Koji Atarashi, Kenya Honda, Lani San Mateo, Scott Plevy, R. Balfour Sartor

    GASTROENTEROLOGY   158 ( 3 )   S59 - S60   2020年2月

    　詳細を見る

    記述言語：英語  

  • HUMAN-DERIVED CLOSTRIDIUM VE202 STRAINS REDUCE ENTEROBACTERIACEAE AND FUSOBACTERIA AND REVERSE EXPERIMENTAL COLITIS INDUCED BY HUMAN GUT MICROBIOTA

    Akihiko Oka, Yoshiyuki Mishima, Gerold Bongers, Andrew Baltus, Bo Liu, Jeremy Herzog, Toshifumi Ohkusa, Koji Atarashi, Kenya Honda, Lani San Mateo, Scott Plevy, R. Balfour Sartor

    INFLAMMATORY BOWEL DISEASES   26   S36 - S37   2020年1月

    　詳細を見る

    記述言語：英語  

    DOI： 10.1093/ibd/zaa010.094

  • Mutualistic skin bacteria protect against dermatitis via the induction of steroid biosynthesis pathways

    Ito Y, Sasaki T, Kawakami E, Suda W, Atarashi K, Amagai M, Honda K

    JOURNAL OF INVESTIGATIVE DERMATOLOGY   139 ( 9 )   S272 - S272   2019年9月

    　詳細を見る

    記述言語：その他  

    Mutualistic skin bacteria protect against dermatitis via the induction of steroid biosynthesis pathways

  • Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis. 査読 国際誌

    Nobuhiro Nakamoto, Nobuo Sasaki, Ryo Aoki, Kentaro Miyamoto, Wataru Suda, Toshiaki Teratani, Takahiro Suzuki, Yuzo Koda, Po-Sung Chu, Nobuhito Taniki, Akihiro Yamaguchi, Mitsuhiro Kanamori, Nobuhiko Kamada, Masahira Hattori, Hiroshi Ashida, Michiie Sakamoto, Koji Atarashi, Seiko Narushima, Akihiko Yoshimura, Kenya Honda, Toshiro Sato, Takanori Kanai

    Nature microbiology   4 ( 3 )   492 - 503   2019年3月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/s41564-018-0333-1

  • IL-10 produced by macrophages regulates epithelial integrity in the small intestine. 査読 国際誌

    Scientific reports   9 ( 1 )   1223 - 1223   2019年2月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/s41598-018-38125-x

  • A defined commensal consortium elicits CD8 T cells and anti-cancer immunity. 査読 国際誌

    Takeshi Tanoue, Satoru Morita, Damian R Plichta, Ashwin N Skelly, Wataru Suda, Yuki Sugiura, Seiko Narushima, Hera Vlamakis, Iori Motoo, Kayoko Sugita, Atsushi Shiota, Kozue Takeshita, Keiko Yasuma-Mitobe, Dieter Riethmacher, Tsuneyasu Kaisho, Jason M Norman, Daniel Mucida, Makoto Suematsu, Tomonori Yaguchi, Vanni Bucci, Takashi Inoue, Yutaka Kawakami, Bernat Olle, Bruce Roberts, Masahira Hattori, Ramnik J Xavier, Koji Atarashi, Kenya Honda

    Nature   565 ( 7741 )   600 - 605   2019年1月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/s41586-019-0878-z

  • Commensal bacteria that can induce CD8 T cells and cancer immunity

    Takeshi Tanoue, Koji Atarashi, Kenya Honda

    CANCER SCIENCE   109   348 - 348   2018年12月

    　詳細を見る

    記述言語：英語  

  • IL-10-INDEPENDENT PROTECTIVE ACTIVITIES OF HUMAN-DERIVED CLOSTRIDIUM STRAINS IN EXPERIMENTAL COLITIS

    Akihiko Oka, Yoshiyuki Mishima, Gerold Bongers, Bo Liu, Jeremy Herzog, Andrew Baltus, Debbie Marshall, Matthias Hesse, Koji Atarashi, Shinji Fukuda, Kenya Honda, Lani San Mateo, Scott Plevy, R. Balfour Sartor

    GASTROENTEROLOGY   154 ( 6 )   S1036 - S1036   2018年5月

    　詳細を見る

    記述言語：英語  

  • Clarithromycin expands CD11b+Gr-1+ cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia. 査読 国際誌

    Ho Namkoong, Makoto Ishii, Hideki Fujii, Kazuma Yagi, Takahiro Asami, Takanori Asakura, Shoji Suzuki, Ahmed E Hegab, Hirofumi Kamata, Sadatomo Tasaka, Koji Atarashi, Nobuhiro Nakamoto, Satoshi Iwata, Kenya Honda, Takanori Kanai, Naoki Hasegawa, Shigeo Koyasu, Tomoko Betsuyaku

    PLoS pathogens   14 ( 4 )   e1006955   2018年4月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1371/journal.ppat.1006955

  • The gut microbiota and cancer immunity

    Kenya Honda, Takeshi Tanoue, Koji Atarashi

    CANCER SCIENCE   109   153 - 153   2018年1月

    　詳細を見る

    記述言語：英語  

  • Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation. 査読 国際誌

    Koji Atarashi, Wataru Suda, Chengwei Luo, Takaaki Kawaguchi, Iori Motoo, Seiko Narushima, Yuya Kiguchi, Keiko Yasuma, Eiichiro Watanabe, Takeshi Tanoue, Christoph A Thaiss, Mayuko Sato, Kiminori Toyooka, Heba S Said, Hirokazu Yamagami, Scott A Rice, Dirk Gevers, Ryan C Johnson, Julia A Segre, Kong Chen, Jay K Kolls, Eran Elinav, Hidetoshi Morita, Ramnik J Xavier, Masahira Hattori, Kenya Honda

    Science (New York, N.Y.)   358 ( 6361 )   359 - 365   2017年10月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1126/science.aan4526

  • Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation. 査読 国際誌

    Koji Atarashi, Wataru Suda, Chengwei Luo, Takaaki Kawaguchi, Iori Motoo, Seiko Narushima, Yuya Kiguchi, Keiko Yasuma, Eiichiro Watanabe, Takeshi Tanoue, Christoph A Thaiss, Mayuko Sato, Kiminori Toyooka, Heba S Said, Hirokazu Yamagami, Scott A Rice, Dirk Gevers, Ryan C Johnson, Julia A Segre, Kong Chen, Jay K Kolls, Eran Elinav, Hidetoshi Morita, Ramnik J Xavier, Masahira Hattori, Kenya Honda

    Science (New York, N.Y.)   358 ( 6361 )   359 - 365   2017年10月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1126/science.aan4526

  • Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring. 査読 国際誌

    Sangdoo Kim, Hyunju Kim, Yeong Shin Yim, Soyoung Ha, Koji Atarashi, Tze Guan Tan, Randy S Longman, Kenya Honda, Dan R Littman, Gloria B Choi, Jun R Huh

    Nature   549 ( 7673 )   528 - 532   2017年9月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/nature23910

  • Clinical impact of pre-transplant gut microbial diversity on outcomes of allogeneic hematopoietic stem cell transplantation. 査読 国際誌

    Noriko Doki, Masahiro Suyama, Satoshi Sasajima, Junko Ota, Aiko Igarashi, Iyo Mimura, Hidetoshi Morita, Yuki Fujioka, Daisuke Sugiyama, Hiroyoshi Nishikawa, Yutaka Shimazu, Wataru Suda, Kozue Takeshita, Koji Atarashi, Masahira Hattori, Eiichi Sato, Kyoko Watakabe-Inamoto, Kosuke Yoshioka, Yuho Najima, Takeshi Kobayashi, Kazuhiko Kakihana, Naoto Takahashi, Hisashi Sakamaki, Kenya Honda, Kazuteru Ohashi

    Annals of hematology   96 ( 9 )   1517 - 1523   2017年9月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1007/s00277-017-3069-8

  • Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring. 査読 国際誌

    Sangdoo Kim, Hyunju Kim, Yeong Shin Yim, Soyoung Ha, Koji Atarashi, Tze Guan Tan, Randy S Longman, Kenya Honda, Dan R Littman, Gloria B Choi, Jun R Huh

    Nature   549 ( 7673 )   528 - 532   2017年9月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/nature23910

  • Commensal bacteria at the crossroad between cholesterol homeostasis and chronic inflammation in atherosclerosis. 査読 国際誌

    Kazuyuki Kasahara, Takeshi Tanoue, Tomoya Yamashita, Keiko Yodoi, Takuya Matsumoto, Takuo Emoto, Taiji Mizoguchi, Tomohiro Hayashi, Naoki Kitano, Naoto Sasaki, Koji Atarashi, Kenya Honda, Ken-Ichi Hirata

    Journal of lipid research   58 ( 3 )   519 - 528   2017年3月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1194/jlr.M072165

  • Commensal bacteria at the crossroad between cholesterol homeostasis and chronic inflammation in atherosclerosis. 査読 国際誌

    Kazuyuki Kasahara, Takeshi Tanoue, Tomoya Yamashita, Keiko Yodoi, Takuya Matsumoto, Takuo Emoto, Taiji Mizoguchi, Tomohiro Hayashi, Naoki Kitano, Naoto Sasaki, Koji Atarashi, Kenya Honda, Ken-Ichi Hirata

    Journal of lipid research   58 ( 3 )   519 - 528   2017年3月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1194/jlr.M072165

  • Corrigendum: A subpopulation of high IL-21-producing CD4+ T cells in Peyer's Patches is induced by the microbiota and regulates germinal centers. 査読 国際誌

    Leigh Jones, Wen Qi Ho, Sze Ying, Lakshmi Ramakrishna, Kandhadayar G Srinivasan, Marina Yurieva, Wan Pei Ng, Sharrada Subramaniam, Nur H Hamadee, Sabrina Joseph, Jayashree Dolpady, Koji Atarashi, Kenya Honda, Francesca Zolezzi, Michael Poidinger, Juan J Lafaille, Maria A Curotto de Lafaille

    Scientific reports   6   34899 - 34899   2016年10月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/srep34899

  • A subpopulation of high IL-21-producing CD4(+) T cells in Peyer's Patches is induced by the microbiota and regulates germinal centers (vol 6, 30784, 2016)

    Leigh Jones, Wen Qi Ho, Sze Ying, Lakshmi Ramakrishna, Kandhadayar G. Srinivasan, Marina Yurieva, Wan Pei Ng, Sharrada Subramaniam, Nur H. Hamadee, Sabrina Joseph, Jayashree Dolpady, Koji Atarashi, Kenya Honda, Francesca Zolezzi, Michael Poidinger, Juan J. Lafaille, Maria A. Curotto de Lafaille

    SCIENTIFIC REPORTS   6   519 - 528   2016年10月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/srep34899

  • Corrigendum: A subpopulation of high IL-21-producing CD4+ T cells in Peyer's Patches is induced by the microbiota and regulates germinal centers. 査読 国際誌

    Leigh Jones, Wen Qi Ho, Sze Ying, Lakshmi Ramakrishna, Kandhadayar G Srinivasan, Marina Yurieva, Wan Pei Ng, Sharrada Subramaniam, Nur H Hamadee, Sabrina Joseph, Jayashree Dolpady, Koji Atarashi, Kenya Honda, Francesca Zolezzi, Michael Poidinger, Juan J Lafaille, Maria A Curotto de Lafaille

    Scientific reports   6   34899 - 34899   2016年10月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/srep34899

  • A subpopulation of high IL-21-producing CD4(+) T cells in Peyer's Patches is induced by the microbiota and regulates germinal centers (vol 6, 30784, 2016)

    Leigh Jones, Wen Qi Ho, Sze Ying, Lakshmi Ramakrishna, Kandhadayar G. Srinivasan, Marina Yurieva, Wan Pei Ng, Sharrada Subramaniam, Nur H. Hamadee, Sabrina Joseph, Jayashree Dolpady, Koji Atarashi, Kenya Honda, Francesca Zolezzi, Michael Poidinger, Juan J. Lafaille, Maria A. Curotto de Lafaille

    SCIENTIFIC REPORTS   6   519 - 528   2016年10月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/srep34899

  • A subpopulation of high IL-21-producing CD4(+) T cells in Peyer's Patches is induced by the microbiota and regulates germinal centers. 査読 国際誌

    Leigh Jones, Wen Qi Ho, Sze Ying, Lakshmi Ramakrishna, Kandhadayar G Srinivasan, Marina Yurieva, Wan Pei Ng, Sharrada Subramaniam, Nur H Hamadee, Sabrina Joseph, Jayashree Dolpady, Koji Atarashi, Kenya Honda, Francesca Zolezzi, Michael Poidinger, Juan J Lafaille, Maria A Curotto de Lafaille

    Scientific reports   6   30784 - 30784   2016年8月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/srep30784

  • A subpopulation of high IL-21-producing CD4(+) T cells in Peyer's Patches is induced by the microbiota and regulates germinal centers. 査読 国際誌

    Leigh Jones, Wen Qi Ho, Sze Ying, Lakshmi Ramakrishna, Kandhadayar G Srinivasan, Marina Yurieva, Wan Pei Ng, Sharrada Subramaniam, Nur H Hamadee, Sabrina Joseph, Jayashree Dolpady, Koji Atarashi, Kenya Honda, Francesca Zolezzi, Michael Poidinger, Juan J Lafaille, Maria A Curotto de Lafaille

    Scientific reports   6   30784 - 30784   2016年8月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/srep30784

  • Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers

    Takuro Saito, Hiroyoshi Nishikawa, Hisashi Wada, Yuji Nagano, Daisuke Sugiyama, Koji Atarashi, Yuka Maeda, Masahide Hamaguchi, Naganari Ohkura, Eiichi Sato, Hirotsugu Nagase, Junichi Nishimura, Hirofumi Yamamoto, Shuji Takiguchi, Takeshi Tanoue, Wataru Suda, Hidetoshi Morita, Masahira Hattori, Kenya Honda, Masaki Mori, Yuichiro Doki, Shimon Sakaguchi

    NATURE MEDICINE   22 ( 6 )   679 - +   2016年6月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/nm.4086

  • Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine. 査読 国際誌

    Takanori Ochi, Yongjia Feng, Sho Kitamoto, Hiroko Nagao-Kitamoto, Peter Kuffa, Koji Atarashi, Kenya Honda, Daniel H Teitelbaum, Nobuhiko Kamada

    Scientific reports   6   27634 - 27634   2016年6月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/srep27634

  • Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers. 査読 国際誌

    Takuro Saito, Hiroyoshi Nishikawa, Hisashi Wada, Yuji Nagano, Daisuke Sugiyama, Koji Atarashi, Yuka Maeda, Masahide Hamaguchi, Naganari Ohkura, Eiichi Sato, Hirotsugu Nagase, Junichi Nishimura, Hirofumi Yamamoto, Shuji Takiguchi, Takeshi Tanoue, Wataru Suda, Hidetoshi Morita, Masahira Hattori, Kenya Honda, Masaki Mori, Yuichiro Doki, Shimon Sakaguchi

    Nature medicine   22 ( 6 )   679 - 84   2016年6月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/nm.4086

  • Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers

    Takuro Saito, Hiroyoshi Nishikawa, Hisashi Wada, Yuji Nagano, Daisuke Sugiyama, Koji Atarashi, Yuka Maeda, Masahide Hamaguchi, Naganari Ohkura, Eiichi Sato, Hirotsugu Nagase, Junichi Nishimura, Hirofumi Yamamoto, Shuji Takiguchi, Takeshi Tanoue, Wataru Suda, Hidetoshi Morita, Masahira Hattori, Kenya Honda, Masaki Mori, Yuichiro Doki, Shimon Sakaguchi

    NATURE MEDICINE   22 ( 6 )   679 - +   2016年6月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/nm.4086

  • Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine. 査読 国際誌

    Takanori Ochi, Yongjia Feng, Sho Kitamoto, Hiroko Nagao-Kitamoto, Peter Kuffa, Koji Atarashi, Kenya Honda, Daniel H Teitelbaum, Nobuhiko Kamada

    Scientific reports   6   27634 - 27634   2016年6月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/srep27634

  • Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers. 査読 国際誌

    Takuro Saito, Hiroyoshi Nishikawa, Hisashi Wada, Yuji Nagano, Daisuke Sugiyama, Koji Atarashi, Yuka Maeda, Masahide Hamaguchi, Naganari Ohkura, Eiichi Sato, Hirotsugu Nagase, Junichi Nishimura, Hirofumi Yamamoto, Shuji Takiguchi, Takeshi Tanoue, Wataru Suda, Hidetoshi Morita, Masahira Hattori, Kenya Honda, Masaki Mori, Yuichiro Doki, Shimon Sakaguchi

    Nature medicine   22 ( 6 )   679 - 84   2016年6月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/nm.4086

  • Development and maintenance of intestinal regulatory T cells. 査読 国際誌

    Takeshi Tanoue, Koji Atarashi, Kenya Honda

    Nature reviews. Immunology   16 ( 5 )   295 - 309   2016年5月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/nri.2016.36

  • Development and maintenance of intestinal regulatory T cells. 査読 国際誌

    Takeshi Tanoue, Koji Atarashi, Kenya Honda

    Nature reviews. Immunology   16 ( 5 )   295 - 309   2016年5月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/nri.2016.36

  • Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells. 査読 国際誌

    Cell   163 ( 2 )   367 - 80   2015年10月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.cell.2015.08.058

  • Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis. 査読 国際誌

    Junko Nishio, Minato Baba, Koji Atarashi, Takeshi Tanoue, Hideo Negishi, Hideyuki Yanai, Sonoko Habu, Shohei Hori, Kenya Honda, Tadatsugu Taniguchi

    Proceedings of the National Academy of Sciences of the United States of America   112 ( 41 )   12770 - 5   2015年10月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1073/pnas.1516617112

  • Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells. 査読 国際誌

    Cell   163 ( 2 )   367 - 80   2015年10月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.cell.2015.08.058

  • Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis. 査読 国際誌

    Junko Nishio, Minato Baba, Koji Atarashi, Takeshi Tanoue, Hideo Negishi, Hideyuki Yanai, Sonoko Habu, Shohei Hori, Kenya Honda, Tadatsugu Taniguchi

    Proceedings of the National Academy of Sciences of the United States of America   112 ( 41 )   12770 - 5   2015年10月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1073/pnas.1516617112

  • The microbiota regulates type 2 immunity through RORγt+ T cells 査読 国際誌

    Ohnmacht Caspar, Park Joo Hong, Cording Sascha, Wing James B, Atarashi Koji, Obata Yuuki, Gaboriau-Routhiau Valérie, Marques Rute, Dulauroy Sophie, Fedoseeva Maria, Busslinger Meinrad, Cerf-Bensussan Nadine, Boneca Ivo G, Voehringer David, Hase Koji, Honda Kenya, Sakaguchi Shimon, Eberl Gérard

    349 ( 6251 )   989 - 93   2015年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    <p>Changes to the symbiotic microbiota early in life, or the absence of it, can lead to exacerbated type 2 immunity and allergic inflammations. Although it is unclear how the microbiota regulates type 2 immunity, it is a strong inducer of proinflammatory T helper 17 (T<inf>H</inf>17) cells and regulatory T cells (T<inf>regs</inf>) in the intestine. Here, we report that microbiota-induced T<inf>regs</inf> express the nuclear hormone receptor RORγt and differentiate along a pathway that also leads to T<inf>H</inf>17 cells. In the absence of RORγt+ T<inf>regs</inf>, T<inf>H</inf>2-driven defense against helminths is more efficient, whereas T<inf>H</inf>2-associated pathology is exacerbated. Thus, the microbiota regulates type 2 responses through the induction of type 3 RORγt+ T<inf>regs</inf> and T<inf>H</inf>17 cells and acts as a key factor in balancing immune responses at mucosal surfaces.</p>

    DOI： 10.1126/science.aac4263

  • The microbiota regulates type 2 immunity through RORγt+ T cells 査読 国際誌

    Ohnmacht Caspar, Park Joo Hong, Cording Sascha, Wing James B, Atarashi Koji, Obata Yuuki, Gaboriau-Routhiau Valérie, Marques Rute, Dulauroy Sophie, Fedoseeva Maria, Busslinger Meinrad, Cerf-Bensussan Nadine, Boneca Ivo G, Voehringer David, Hase Koji, Honda Kenya, Sakaguchi Shimon, Eberl Gérard

    349 ( 6251 )   989 - 93   2015年8月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    <p>Changes to the symbiotic microbiota early in life, or the absence of it, can lead to exacerbated type 2 immunity and allergic inflammations. Although it is unclear how the microbiota regulates type 2 immunity, it is a strong inducer of proinflammatory T helper 17 (T<inf>H</inf>17) cells and regulatory T cells (T<inf>regs</inf>) in the intestine. Here, we report that microbiota-induced T<inf>regs</inf> express the nuclear hormone receptor RORγt and differentiate along a pathway that also leads to T<inf>H</inf>17 cells. In the absence of RORγt+ T<inf>regs</inf>, T<inf>H</inf>2-driven defense against helminths is more efficient, whereas T<inf>H</inf>2-associated pathology is exacerbated. Thus, the microbiota regulates type 2 responses through the induction of type 3 RORγt+ T<inf>regs</inf> and T<inf>H</inf>17 cells and acts as a key factor in balancing immune responses at mucosal surfaces.</p>

    DOI： 10.1126/science.aac4263

  • Foxp3(+) T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis. 査読 国際誌

    Shimpei Kawamoto, Mikako Maruya, Lucia M Kato, Wataru Suda, Koji Atarashi, Yasuko Doi, Yumi Tsutsui, Hongyan Qin, Kenya Honda, Takaharu Okada, Masahira Hattori, Sidonia Fagarasan

    Immunity   41 ( 1 )   152 - 65   2014年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.immuni.2014.05.016

  • Foxp3(+) T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis. 査読 国際誌

    Shimpei Kawamoto, Mikako Maruya, Lucia M Kato, Wataru Suda, Koji Atarashi, Yasuko Doi, Yumi Tsutsui, Hongyan Qin, Kenya Honda, Takaharu Okada, Masahira Hattori, Sidonia Fagarasan

    Immunity   41 ( 1 )   152 - 65   2014年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.immuni.2014.05.016

  • The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells. 査読 国際誌

    Yuuki Obata, Yukihiro Furusawa, Takaho A Endo, Jafar Sharif, Daisuke Takahashi, Koji Atarashi, Manabu Nakayama, Satoshi Onawa, Yumiko Fujimura, Masumi Takahashi, Tomokatsu Ikawa, Takeshi Otsubo, Yuki I Kawamura, Taeko Dohi, Shoji Tajima, Hiroshi Masumoto, Osamu Ohara, Kenya Honda, Shohei Hori, Hiroshi Ohno, Haruhiko Koseki, Koji Hase

    Nature immunology   15 ( 6 )   571 - 9   2014年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/ni.2886

  • The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells. 査読 国際誌

    Yuuki Obata, Yukihiro Furusawa, Takaho A Endo, Jafar Sharif, Daisuke Takahashi, Koji Atarashi, Manabu Nakayama, Satoshi Onawa, Yumiko Fujimura, Masumi Takahashi, Tomokatsu Ikawa, Takeshi Otsubo, Yuki I Kawamura, Taeko Dohi, Shoji Tajima, Hiroshi Masumoto, Osamu Ohara, Kenya Honda, Shohei Hori, Hiroshi Ohno, Haruhiko Koseki, Koji Hase

    Nature immunology   15 ( 6 )   571 - 9   2014年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/ni.2886

  • The epigenetic regulator Uhrf1 is critical for functional expansion of colonic regulatory T cells. 査読

    Obata Y, Furusawa Y, Endo TA, Sharif J, Takahashi D, Atarashi K, Onawa S, Fujimura Y, Takahashi M, Ikawa T, Otsubo T, Kawamura YI, Dohi T, Tajima S, Ohara O, Honda K, Hori S, Ohno H, Koseki H, Hase K

    Nat Immunol   15   571-579   2014年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Epigenetic regulator Uhrf1 is critical for functional expansion of colonic regulatory T cells.

  • Characterization of the 17 strains of regulatory T cell-inducing human-derived Clostridia

    Narushima Seiko, Sugiura Yuki, Oshima Kenshiro, Atarashi Koji, Hattori Masahira, Suematsu Makoto, Honda Kenya

    Gut Microbes   5 ( 3 )   333 - 339   2014年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Characterization of the 17 strains of regulatory T cell-inducing human-derived Clostridia
    <p>The gut microbiota plays important roles in the development of the host immune system. We have previously shown that a combination of 46 strains of commensal Clostridia isolated from conventionally reared mice can induce the accumulation of CD4(+)Foxp3(+) regulatory T (Treg) cells in the mouse colonic lamina propria. Subsequently, we succeeded in isolating and selecting 17 strains of Clostridia from a healthy human fecal sample that can significantly increase the number and function of colonic Treg cells in colonized rodents, thereby attenuating symptoms of experimental allergic diarrhea and colitis. Here we characterize each of the 17 strains of human-derived Clostridia in terms of sensitivity to antibiotics and ability to produce short chain fatty acids and other metabolites, and discuss their potential as biotherapeutics to correct dysbiosis and treat immune-inflammatory diseases. </p>

    DOI： 10.4161/gmic.28572

  • The epigenetic regulator Uhrf1 is critical for functional expansion of colonic regulatory T cells. 査読

    Obata Y, Furusawa Y, Endo TA, Sharif J, Takahashi D, Atarashi K, Onawa S, Fujimura Y, Takahashi M, Ikawa T, Otsubo T, Kawamura YI, Dohi T, Tajima S, Ohara O, Honda K, Hori S, Ohno H, Koseki H, Hase K

    Nat Immunol   15   571-579   2014年5月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Epigenetic regulator Uhrf1 is critical for functional expansion of colonic regulatory T cells.

  • Characterization of the 17 strains of regulatory T cell-inducing human-derived Clostridia

    Narushima Seiko, Sugiura Yuki, Oshima Kenshiro, Atarashi Koji, Hattori Masahira, Suematsu Makoto, Honda Kenya

    Gut Microbes   5 ( 3 )   333 - 339   2014年5月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Characterization of the 17 strains of regulatory T cell-inducing human-derived Clostridia
    <p>The gut microbiota plays important roles in the development of the host immune system. We have previously shown that a combination of 46 strains of commensal Clostridia isolated from conventionally reared mice can induce the accumulation of CD4(+)Foxp3(+) regulatory T (Treg) cells in the mouse colonic lamina propria. Subsequently, we succeeded in isolating and selecting 17 strains of Clostridia from a healthy human fecal sample that can significantly increase the number and function of colonic Treg cells in colonized rodents, thereby attenuating symptoms of experimental allergic diarrhea and colitis. Here we characterize each of the 17 strains of human-derived Clostridia in terms of sensitivity to antibiotics and ability to produce short chain fatty acids and other metabolites, and discuss their potential as biotherapeutics to correct dysbiosis and treat immune-inflammatory diseases. </p>

    DOI： 10.4161/gmic.28572

  • MAVS-dependent IRF3/7 bypass of interferon β-induction restricts the response to measles infection in CD150Tg mouse bone marrow-derived dendritic cells 査読 国際誌

    57 ( 2 )   100 - 10   2014年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    <p>Measles virus (MV) infects CD150Tg/Ifnar (IFN alpha receptor)-/- mice but not CD150 (a human MV receptor)-transgenic (Tg) mice. We have shown that bone marrow-derived dendritic cells (BMDCs) from CD150Tg/Ifnar-/- mice are permissive to MV in contrast to those from simple CD150Tg mice, which reveals a crucial role of type I interferon (IFN) in natural tropism against MV. Yet, the mechanism whereby BMDCs produce initial type I IFN has not been elucidated in MV infection. RNA virus infection usually allows cells to generate double-stranded RNA and induce activation of IFN regulatory factor (IRF) 3/7 transcription factors, leading to the production of type I IFN through the retinoic acid-inducible gene I (RIG-I)/melanoma differentiation-associated gene 5 (MDA5)-mitochondrial antiviral signaling protein (MAVS) pathway. In mouse experimental BMDCs models, we found CD150Tg/Mavs-/-BMDCs, but not CD150Tg/Irf3-/-/Irf7-/-BMDCs, permissive to MV. IFN-α/β were not induced in MV-infected CD150Tg/Mavs-/-BMDCs, while IFN-β was subtly induced in CD150Tg/Irf3-/-/Irf7-/-BMDCs. In vivo systemic infection was

    DOI： 10.1016/j.molimm.2013.08.007

  • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells (vol 504, pg 446, 2013)

    Yukihiro Furusawa, Yuuki Obata, Shinji Fukuda, Takaho A. Endo, Gaku Nakato, Daisuke Takahashi, Yumiko Nakanishi, Chikako Uetake, Keiko Kato, Tamotsu Kato, Masumi Takahashi, Noriko N. Fukuda, Shinnosuke Murakami, Eiji Miyauchi, Shingo Hino, Koji Atarashi, Satoshi Onawa, Yumiko Fujimura, Trevor Lockett, Julie M. Clarke, David L. Topping, Masaru Tomita, Shohei Hori, Osamu Ohara, Tatsuya Morita, Haruhiko Koseki, Jun Kikuchi, Kenya Honda, Koji Hase, Hiroshi Ohno

    NATURE   506 ( 7487 )   2014年2月

    　詳細を見る

    記述言語：英語  

    DOI： 10.1038/nature13041

  • MAVS-dependent IRF3/7 bypass of interferon β-induction restricts the response to measles infection in CD150Tg mouse bone marrow-derived dendritic cells 査読 国際誌

    57 ( 2 )   100 - 10   2014年2月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    <p>Measles virus (MV) infects CD150Tg/Ifnar (IFN alpha receptor)-/- mice but not CD150 (a human MV receptor)-transgenic (Tg) mice. We have shown that bone marrow-derived dendritic cells (BMDCs) from CD150Tg/Ifnar-/- mice are permissive to MV in contrast to those from simple CD150Tg mice, which reveals a crucial role of type I interferon (IFN) in natural tropism against MV. Yet, the mechanism whereby BMDCs produce initial type I IFN has not been elucidated in MV infection. RNA virus infection usually allows cells to generate double-stranded RNA and induce activation of IFN regulatory factor (IRF) 3/7 transcription factors, leading to the production of type I IFN through the retinoic acid-inducible gene I (RIG-I)/melanoma differentiation-associated gene 5 (MDA5)-mitochondrial antiviral signaling protein (MAVS) pathway. In mouse experimental BMDCs models, we found CD150Tg/Mavs-/-BMDCs, but not CD150Tg/Irf3-/-/Irf7-/-BMDCs, permissive to MV. IFN-α/β were not induced in MV-infected CD150Tg/Mavs-/-BMDCs, while IFN-β was subtly induced in CD150Tg/Irf3-/-/Irf7-/-BMDCs. In vivo systemic infection was

    DOI： 10.1016/j.molimm.2013.08.007

  • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells (vol 504, pg 446, 2013)

    Yukihiro Furusawa, Yuuki Obata, Shinji Fukuda, Takaho A. Endo, Gaku Nakato, Daisuke Takahashi, Yumiko Nakanishi, Chikako Uetake, Keiko Kato, Tamotsu Kato, Masumi Takahashi, Noriko N. Fukuda, Shinnosuke Murakami, Eiji Miyauchi, Shingo Hino, Koji Atarashi, Satoshi Onawa, Yumiko Fujimura, Trevor Lockett, Julie M. Clarke, David L. Topping, Masaru Tomita, Shohei Hori, Osamu Ohara, Tatsuya Morita, Haruhiko Koseki, Jun Kikuchi, Kenya Honda, Koji Hase, Hiroshi Ohno

    NATURE   506 ( 7487 )   2014年2月

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    記述言語：英語  

    DOI： 10.1038/nature13041

  • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. 査読 国際誌

    Yukihiro Furusawa, Yuuki Obata, Shinji Fukuda, Takaho A Endo, Gaku Nakato, Daisuke Takahashi, Yumiko Nakanishi, Chikako Uetake, Keiko Kato, Tamotsu Kato, Masumi Takahashi, Noriko N Fukuda, Shinnosuke Murakami, Eiji Miyauchi, Shingo Hino, Koji Atarashi, Satoshi Onawa, Yumiko Fujimura, Trevor Lockett, Julie M Clarke, David L Topping, Masaru Tomita, Shohei Hori, Osamu Ohara, Tatsuya Morita, Haruhiko Koseki, Jun Kikuchi, Kenya Honda, Koji Hase, Hiroshi Ohno

    Nature   504 ( 7480 )   446 - 50   2013年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/nature12721

  • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. 査読 国際誌

    Yukihiro Furusawa, Yuuki Obata, Shinji Fukuda, Takaho A Endo, Gaku Nakato, Daisuke Takahashi, Yumiko Nakanishi, Chikako Uetake, Keiko Kato, Tamotsu Kato, Masumi Takahashi, Noriko N Fukuda, Shinnosuke Murakami, Eiji Miyauchi, Shingo Hino, Koji Atarashi, Satoshi Onawa, Yumiko Fujimura, Trevor Lockett, Julie M Clarke, David L Topping, Masaru Tomita, Shohei Hori, Osamu Ohara, Tatsuya Morita, Haruhiko Koseki, Jun Kikuchi, Kenya Honda, Koji Hase, Hiroshi Ohno

    Nature   504 ( 7480 )   446 - 50   2013年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/nature12721

  • Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses. 査読 国際誌

    Immunity   39 ( 3 )   584 - 98   2013年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.immuni.2013.06.019

  • Monocyte-Derived Dendritic Cells Perform Hemophagocytosis to Fine-Tune Excessive Immune Responses

    Hideaki Ohyagi, Nobuyuki Onai, Taku Sato, Satoshi Yotsumoto, Jiajia Liu, Hisaya Akiba, Hideo Yagita, Koji Atarashi, Kenya Honda, Axel Roers, Werner Mueller, Kazutaka Kurabayashi, Mayuka Hosoi-Amaike, Naoto Takahashi, Makoto Hirokawa, Kouji Matsushima, Kenichi Sawada, Toshiaki Ohteki

    IMMUNITY   39 ( 3 )   584 - 598   2013年9月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.immuni.2013.06.019

  • Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses. 査読 国際誌

    Immunity   39 ( 3 )   584 - 98   2013年9月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.immuni.2013.06.019

  • Monocyte-Derived Dendritic Cells Perform Hemophagocytosis to Fine-Tune Excessive Immune Responses

    Hideaki Ohyagi, Nobuyuki Onai, Taku Sato, Satoshi Yotsumoto, Jiajia Liu, Hisaya Akiba, Hideo Yagita, Koji Atarashi, Kenya Honda, Axel Roers, Werner Mueller, Kazutaka Kurabayashi, Mayuka Hosoi-Amaike, Naoto Takahashi, Makoto Hirokawa, Kouji Matsushima, Kenichi Sawada, Toshiaki Ohteki

    IMMUNITY   39 ( 3 )   584 - 598   2013年9月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.immuni.2013.06.019

  • Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. 査読 国際誌

    Nature   500 ( 7461 )   232 - 6   2013年8月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/nature12331

  • Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. 査読 国際誌

    Nature   500 ( 7461 )   232 - 6   2013年8月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/nature12331

  • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. 査読 国際誌

    Shin Yoshimoto, Tze Mun Loo, Koji Atarashi, Hiroaki Kanda, Seidai Sato, Seiichi Oyadomari, Yoichiro Iwakura, Kenshiro Oshima, Hidetoshi Morita, Masahira Hattori, Kenya Honda, Yuichi Ishikawa, Eiji Hara, Naoko Ohtani

    Nature   499 ( 7456 )   97 - 101   2013年7月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/nature12347

  • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. 査読 国際誌

    Shin Yoshimoto, Tze Mun Loo, Koji Atarashi, Hiroaki Kanda, Seidai Sato, Seiichi Oyadomari, Yoichiro Iwakura, Kenshiro Oshima, Hidetoshi Morita, Masahira Hattori, Kenya Honda, Yuichi Ishikawa, Eiji Hara, Naoko Ohtani

    Nature   499 ( 7456 )   97 - 101   2013年7月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/nature12347

  • IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. 査読 国際誌

    Andreas Schlitzer, Naomi McGovern, Pearline Teo, Teresa Zelante, Koji Atarashi, Donovan Low, Adrian W S Ho, Peter See, Amanda Shin, Pavandip Singh Wasan, Guillaume Hoeffel, Benoit Malleret, Alexander Heiseke, Samantha Chew, Laura Jardine, Harriet A Purvis, Catharien M U Hilkens, John Tam, Michael Poidinger, E Richard Stanley, Anne B Krug, Laurent Renia, Baalasubramanian Sivasankar, Lai Guan Ng, Matthew Collin, Paola Ricciardi-Castagnoli, Kenya Honda, Muzlifah Haniffa, Florent Ginhoux

    Immunity   38 ( 5 )   970 - 83   2013年5月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.immuni.2013.04.011

  • IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. 査読 国際誌

    Andreas Schlitzer, Naomi McGovern, Pearline Teo, Teresa Zelante, Koji Atarashi, Donovan Low, Adrian W S Ho, Peter See, Amanda Shin, Pavandip Singh Wasan, Guillaume Hoeffel, Benoit Malleret, Alexander Heiseke, Samantha Chew, Laura Jardine, Harriet A Purvis, Catharien M U Hilkens, John Tam, Michael Poidinger, E Richard Stanley, Anne B Krug, Laurent Renia, Baalasubramanian Sivasankar, Lai Guan Ng, Matthew Collin, Paola Ricciardi-Castagnoli, Kenya Honda, Muzlifah Haniffa, Florent Ginhoux

    Immunity   38 ( 5 )   970 - 83   2013年5月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.immuni.2013.04.011

  • Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes. 査読 国際誌

    14 ( 3 )   281 - 9   2013年3月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    TCRαβ thymocytes differentiate into either CD8αβ(+) cytotoxic T lymphocytes or CD4(+) helper T cells. This functional dichotomy is controlled by key transcription factors, including the helper T cell master regulator ThPOK, which suppresses the cytolytic program in major histocompatibility complex (MHC) class II-restricted CD4(+) thymocytes. ThPOK continues to repress genes of the CD8 lineage in mature CD4(+) T cells, even as they differentiate into effector helper T cell subsets. Here we found that the helper T cell fate was not fixed and that mature, antigen-stimulated CD4(+) T cells terminated expression of the gene encoding ThPOK and reactivated genes of the CD8 lineage. This unexpected plasticity resulted in the post-thymic termination of the helper T cell program and the functional differentiation of distinct MHC class II-restricted CD4(+) cytotoxic T lymphocytes.

    DOI： 10.1038/ni.2523

  • Transcriptional reprogramming of mature CD4(+) helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes

    Daniel Mucida, Mohammad Mushtaq Husain, Sawako Muroi, Femke van Wijk, Ryo Shinnakasu, Yoshinori Naoe, Bernardo Sgarbi Reis, Yujun Huang, Florence Lambolez, Michael Docherty, Antoine Attinger, Jr-Wen Shui, Gisen Kim, Christopher J. Lena, Shinya Sakaguchi, Chizuko Miyamoto, Peng Wang, Koji Atarashi, Yunji Park, Toshinori Nakayama, Kenya Honda, Wilfried Ellmeier, Mitchell Kronenberg, Ichiro Taniuchi, Hilde Cheroutre

    NATURE IMMUNOLOGY   14 ( 3 )   281 - 289   2013年3月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/ni.2523

  • Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes. 査読 国際誌

    14 ( 3 )   281 - 9   2013年3月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    TCRαβ thymocytes differentiate into either CD8αβ(+) cytotoxic T lymphocytes or CD4(+) helper T cells. This functional dichotomy is controlled by key transcription factors, including the helper T cell master regulator ThPOK, which suppresses the cytolytic program in major histocompatibility complex (MHC) class II-restricted CD4(+) thymocytes. ThPOK continues to repress genes of the CD8 lineage in mature CD4(+) T cells, even as they differentiate into effector helper T cell subsets. Here we found that the helper T cell fate was not fixed and that mature, antigen-stimulated CD4(+) T cells terminated expression of the gene encoding ThPOK and reactivated genes of the CD8 lineage. This unexpected plasticity resulted in the post-thymic termination of the helper T cell program and the functional differentiation of distinct MHC class II-restricted CD4(+) cytotoxic T lymphocytes.

    DOI： 10.1038/ni.2523

  • Transcriptional reprogramming of mature CD4(+) helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes

    Daniel Mucida, Mohammad Mushtaq Husain, Sawako Muroi, Femke van Wijk, Ryo Shinnakasu, Yoshinori Naoe, Bernardo Sgarbi Reis, Yujun Huang, Florence Lambolez, Michael Docherty, Antoine Attinger, Jr-Wen Shui, Gisen Kim, Christopher J. Lena, Shinya Sakaguchi, Chizuko Miyamoto, Peng Wang, Koji Atarashi, Yunji Park, Toshinori Nakayama, Kenya Honda, Wilfried Ellmeier, Mitchell Kronenberg, Ichiro Taniuchi, Hilde Cheroutre

    NATURE IMMUNOLOGY   14 ( 3 )   281 - 289   2013年3月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/ni.2523

  • Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine. 査読 国際誌

    Takashi Kusu, Hisako Kayama, Makoto Kinoshita, Seong Gyu Jeon, Yoshiyasu Ueda, Yoshiyuki Goto, Ryu Okumura, Hiroyuki Saiga, Takashi Kurakawa, Kayo Ikeda, Yuichi Maeda, Jun-ichi Nishimura, Yasunobu Arima, Koji Atarashi, Kenya Honda, Masaaki Murakami, Jun Kunisawa, Hiroshi Kiyono, Meinoshin Okumura, Masahiro Yamamoto, Kiyoshi Takeda

    Journal of immunology (Baltimore, Md. : 1950)   190 ( 2 )   774 - 83   2013年1月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.4049/jimmunol.1103067

  • Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine. 査読 国際誌

    Takashi Kusu, Hisako Kayama, Makoto Kinoshita, Seong Gyu Jeon, Yoshiyasu Ueda, Yoshiyuki Goto, Ryu Okumura, Hiroyuki Saiga, Takashi Kurakawa, Kayo Ikeda, Yuichi Maeda, Jun-ichi Nishimura, Yasunobu Arima, Koji Atarashi, Kenya Honda, Masaaki Murakami, Jun Kunisawa, Hiroshi Kiyono, Meinoshin Okumura, Masahiro Yamamoto, Kiyoshi Takeda

    Journal of immunology (Baltimore, Md. : 1950)   190 ( 2 )   774 - 83   2013年1月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.4049/jimmunol.1103067

  • Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses. 査読 国際誌

    Hideo Negishi, Hideyuki Yanai, Akira Nakajima, Ryuji Koshiba, Koji Atarashi, Atsushi Matsuda, Kosuke Matsuki, Shoji Miki, Takahiro Doi, Alan Aderem, Junko Nishio, Stephen T Smale, Kenya Honda, Tadatsugu Taniguchi

    Nature immunology   13 ( 7 )   659 - 66   2012年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/ni.2307

  • Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses. 査読 国際誌

    Hideo Negishi, Hideyuki Yanai, Akira Nakajima, Ryuji Koshiba, Koji Atarashi, Atsushi Matsuda, Kosuke Matsuki, Shoji Miki, Takahiro Doi, Alan Aderem, Junko Nishio, Stephen T Smale, Kenya Honda, Tadatsugu Taniguchi

    Nature immunology   13 ( 7 )   659 - 66   2012年5月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/ni.2307

  • Microbial recognition and pathogen-associated molecular pattern receptors in inflammatory bowel disease 査読

    Kenya Honda, Koji Atarashi, Junko Nishio

    Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach   97 - 110   2012年1月

    　詳細を見る

    記述言語：英語  

    DOI： 10.1007/978-1-4614-0998-4_6

  • Microbial recognition and pathogen-associated molecular pattern receptors in inflammatory bowel disease 査読

    Kenya Honda, Koji Atarashi, Junko Nishio

    Crohn's Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach   97 - 110   2012年1月

    　詳細を見る

    記述言語：英語  

    DOI： 10.1007/978-1-4614-0998-4_6

  • Microbiota in autoimmunity and tolerance. 査読 国際誌

    Koji Atarashi, Kenya Honda

    Current opinion in immunology   23 ( 6 )   761 - 8   2011年12月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.coi.2011.11.002

  • Microbiota in autoimmunity and tolerance. 査読 国際誌

    Koji Atarashi, Kenya Honda

    Current opinion in immunology   23 ( 6 )   761 - 8   2011年12月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.coi.2011.11.002

  • The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. 査読 国際誌

    Yasutaka Motomura, Hiroshi Kitamura, Atsushi Hijikata, Yuko Matsunaga, Koichiro Matsumoto, Hiromasa Inoue, Koji Atarashi, Shohei Hori, Hiroshi Watarai, Jinfang Zhu, Masaru Taniguchi, Masato Kubo

    Nature immunology   12 ( 5 )   450 - 9   2011年5月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/ni.2020

  • The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. 査読 国際誌

    Yasutaka Motomura, Hiroshi Kitamura, Atsushi Hijikata, Yuko Matsunaga, Koichiro Matsumoto, Hiromasa Inoue, Koji Atarashi, Shohei Hori, Hiroshi Watarai, Jinfang Zhu, Masaru Taniguchi, Masato Kubo

    Nature immunology   12 ( 5 )   450 - 9   2011年5月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/ni.2020

  • Microbiotal influence on T cell subset development. 査読 国際誌

    Koji Atarashi, Yoshinori Umesaki, Kenya Honda

    Seminars in immunology   23 ( 2 )   146 - 53   2011年4月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.smim.2011.01.010

  • Microbiotal influence on T cell subset development. 査読 国際誌

    Koji Atarashi, Yoshinori Umesaki, Kenya Honda

    Seminars in immunology   23 ( 2 )   146 - 53   2011年4月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.smim.2011.01.010

  • Induction of colonic regulatory T cells by indigenous Clostridium species. 査読 国際誌

    Koji Atarashi, Takeshi Tanoue, Tatsuichiro Shima, Akemi Imaoka, Tomomi Kuwahara, Yoshika Momose, Genhong Cheng, Sho Yamasaki, Takashi Saito, Yusuke Ohba, Tadatsugu Taniguchi, Kiyoshi Takeda, Shohei Hori, Ivaylo I Ivanov, Yoshinori Umesaki, Kikuji Itoh, Kenya Honda

    Science (New York, N.Y.)   331 ( 6015 )   337 - 41   2011年1月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1126/science.1198469

  • Induction of colonic regulatory T cells by indigenous Clostridium species. 査読 国際誌

    Koji Atarashi, Takeshi Tanoue, Tatsuichiro Shima, Akemi Imaoka, Tomomi Kuwahara, Yoshika Momose, Genhong Cheng, Sho Yamasaki, Takashi Saito, Yusuke Ohba, Tadatsugu Taniguchi, Kiyoshi Takeda, Shohei Hori, Ivaylo I Ivanov, Yoshinori Umesaki, Kikuji Itoh, Kenya Honda

    Science (New York, N.Y.)   331 ( 6015 )   337 - 41   2011年1月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1126/science.1198469

  • Regulation of Th17 cell differentiation by intestinal commensal bacteria

    K. Atarashi, T. Tanoue, Y. Umesaki, K. Honda

    BENEFICIAL MICROBES   1 ( 4 )   327 - 334   2010年12月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.3920/BM2010.0026

  • Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

    Atarashi Koji, Tanoue Takeshi, Shima Tatsuichiro, Imaoka Akemi, Kuwahara Tomomi, Momose Yoshika, Cheng Genhong, Yamasaki Sho, Saito Takashi, Ohba Yusuke, Taniguchi Tadatsugu, Takeda Kiyoshi, Hori Shohei, Ivanov Ivaylo I, Umesaki Yoshinori, Itoh Kikuji, Honda Kenya

    Science   1 - 5   2010年12月

    　詳細を見る

    記述言語：英語  

    Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
    <p>CD4+ T regulatory cells (Tregs), expressing the Foxp3 transcription factor, play a critical role in the maintenance of immune homeostasis. Here, we show that in mice, Tregs were most abundant in the colonic mucosa. The spore-forming component of indigenous intestinal microbiota-particularly clusters IV and XIVa of the genus Clostridium, promoted Treg cell accumulation. Colonization of mice by a defined mix of Clostridium strains provided an environment rich in transforming growth factor-β (TGF-β) and affected Foxp3+ Treg number and function in the colon. Oral inoculation of Clostridium during the early life of conventionally reared mice resulted in resistance to colitis and systemic IgE responses in adult mice, suggesting a new therapeutic approach to autoimmunity and allergy.</p>

    DOI： 10.1126/science.

  • Regulation of Th17 cell differentiation by intestinal commensal bacteria

    K. Atarashi, T. Tanoue, Y. Umesaki, K. Honda

    BENEFICIAL MICROBES   1 ( 4 )   327 - 334   2010年12月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.3920/BM2010.0026

  • Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

    Atarashi Koji, Tanoue Takeshi, Shima Tatsuichiro, Imaoka Akemi, Kuwahara Tomomi, Momose Yoshika, Cheng Genhong, Yamasaki Sho, Saito Takashi, Ohba Yusuke, Taniguchi Tadatsugu, Takeda Kiyoshi, Hori Shohei, Ivanov Ivaylo I, Umesaki Yoshinori, Itoh Kikuji, Honda Kenya

    Science   1 - 5   2010年12月

    　詳細を見る

    記述言語：英語  

    Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
    <p>CD4+ T regulatory cells (Tregs), expressing the Foxp3 transcription factor, play a critical role in the maintenance of immune homeostasis. Here, we show that in mice, Tregs were most abundant in the colonic mucosa. The spore-forming component of indigenous intestinal microbiota-particularly clusters IV and XIVa of the genus Clostridium, promoted Treg cell accumulation. Colonization of mice by a defined mix of Clostridium strains provided an environment rich in transforming growth factor-β (TGF-β) and affected Foxp3+ Treg number and function in the colon. Oral inoculation of Clostridium during the early life of conventionally reared mice resulted in resistance to colitis and systemic IgE responses in adult mice, suggesting a new therapeutic approach to autoimmunity and allergy.</p>

    DOI： 10.1126/science.

  • Induction of lamina propria Th17 cells by intestinal commensal bacteria. 査読 国際誌

    Koji Atarashi, Takeshi Tanoue, Kenya Honda

    Vaccine   28 ( 50 )   8036 - 8   2010年11月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.vaccine.2010.09.026

  • Induction of lamina propria Th17 cells by intestinal commensal bacteria. 査読 国際誌

    Koji Atarashi, Takeshi Tanoue, Kenya Honda

    Vaccine   28 ( 50 )   8036 - 8   2010年11月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.vaccine.2010.09.026

  • A novel in vivo inducible dendritic cell ablation model in mice. 査読 国際誌

    Megumi Okuyama, Hisako Kayama, Koji Atarashi, Hiroyuki Saiga, Taishi Kimura, Ari Waisman, Masahiro Yamamoto, Kiyoshi Takeda

    Biochemical and biophysical research communications   397 ( 3 )   559 - 63   2010年7月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.bbrc.2010.05.157

  • A novel in vivo inducible dendritic cell ablation model in mice. 査読 国際誌

    Megumi Okuyama, Hisako Kayama, Koji Atarashi, Hiroyuki Saiga, Taishi Kimura, Ari Waisman, Masahiro Yamamoto, Kiyoshi Takeda

    Biochemical and biophysical research communications   397 ( 3 )   559 - 63   2010年7月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.bbrc.2010.05.157

  • Induction of intestinal Th17 cells by segmented filamentous bacteria. 査読 国際誌

    Ivaylo I Ivanov, Koji Atarashi, Nicolas Manel, Eoin L Brodie, Tatsuichiro Shima, Ulas Karaoz, Dongguang Wei, Katherine C Goldfarb, Clark A Santee, Susan V Lynch, Takeshi Tanoue, Akemi Imaoka, Kikuji Itoh, Kiyoshi Takeda, Yoshinori Umesaki, Kenya Honda, Dan R Littman

    Cell   139 ( 3 )   485 - 98   2009年10月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.cell.2009.09.033

  • Induction of intestinal Th17 cells by segmented filamentous bacteria. 査読 国際誌

    Ivaylo I Ivanov, Koji Atarashi, Nicolas Manel, Eoin L Brodie, Tatsuichiro Shima, Ulas Karaoz, Dongguang Wei, Katherine C Goldfarb, Clark A Santee, Susan V Lynch, Takeshi Tanoue, Akemi Imaoka, Kikuji Itoh, Kiyoshi Takeda, Yoshinori Umesaki, Kenya Honda, Dan R Littman

    Cell   139 ( 3 )   485 - 98   2009年10月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.cell.2009.09.033

  • NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection. 査読 国際誌

    Hisako Kayama, Ritsuko Koga, Koji Atarashi, Megumi Okuyama, Taishi Kimura, Tak W Mak, Satoshi Uematsu, Shizuo Akira, Hiroshi Takayanagi, Kenya Honda, Masahiro Yamamoto, Kiyoshi Takeda

    PLoS pathogens   5 ( 7 )   e1000514   2009年7月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1371/journal.ppat.1000514

  • NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection. 査読 国際誌

    Hisako Kayama, Ritsuko Koga, Koji Atarashi, Megumi Okuyama, Taishi Kimura, Tak W Mak, Satoshi Uematsu, Shizuo Akira, Hiroshi Takayanagi, Kenya Honda, Masahiro Yamamoto, Kiyoshi Takeda

    PLoS pathogens   5 ( 7 )   e1000514   2009年7月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1371/journal.ppat.1000514

  • Fra-1 negatively regulates lipopolysaccharide-mediated inflammatory responses. 査読 国際誌

    Hideaki Morishita, Fumiji Saito, Hisako Kayama, Koji Atarashi, Hirotaka Kuwata, Masahiro Yamamoto, Kiyoshi Takeda

    International immunology   21 ( 4 )   457 - 65   2009年4月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1093/intimm/dxp015

  • Fra-1 negatively regulates lipopolysaccharide-mediated inflammatory responses. 査読 国際誌

    Hideaki Morishita, Fumiji Saito, Hisako Kayama, Koji Atarashi, Hirotaka Kuwata, Masahiro Yamamoto, Kiyoshi Takeda

    International immunology   21 ( 4 )   457 - 65   2009年4月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1093/intimm/dxp015

  • ATP drives lamina propria T(H)17 cell differentiation. 査読 国際誌

    Koji Atarashi, Junichi Nishimura, Tatsuichiro Shima, Yoshinori Umesaki, Masahiro Yamamoto, Masaharu Onoue, Hideo Yagita, Naoto Ishii, Richard Evans, Kenya Honda, Kiyoshi Takeda

    Nature   455 ( 7214 )   808 - 12   2008年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/nature07240

  • ATP drives lamina propria T(H)17 cell differentiation. 査読 国際誌

    Koji Atarashi, Junichi Nishimura, Tatsuichiro Shima, Yoshinori Umesaki, Masahiro Yamamoto, Masaharu Onoue, Hideo Yagita, Naoto Ishii, Richard Evans, Kenya Honda, Kiyoshi Takeda

    Nature   455 ( 7214 )   808 - 12   2008年10月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1038/nature07240

  • TLR-dependent induction of IFN-β mediates host defense against Trypanosoma cruzi 査読 国際誌

    177 ( 10 )   7059 - 66   2006年11月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    <p>Host resistance to the intracellular protozoan parasite Trypanosoma cruzi depends on IFN-γ production by T cells and NK cells. However, the involvement of innate immunity in host resistance to T. cruzi remains unclear. In the present study, we investigated host defense against T. cruzi by focusing on innate immunity. Macrophages and dendritic cells (DCs) from MyD88 -/-TRIF-/- mice, in which TLR-dependent activation of innate immunity was abolished, were defective in the clearance of T. cruzi and showed impaired induction of TFN-β during T. cruzi infection. Neutralization of IFN-β in MyD88-/- macrophages led to enhanced T. cruzi growth. Cells from MyD88-/-IFNAR1-/- mice also showed impaired T. cruzi clearance. Furthermore, both MyD88 -/-TRIF-/- and MyD88-/-IFNAR1-/- mice were highly susceptible to in vivo T. cruzi infection, highlighting the involvement of innate immune responses in T. cruzi infection. We further analyzed the molecular mechanisms for the IFN-β-mediated antitrypanosomal innate immune responses. MyD88-/-TRIF-/- and MyD88 -/-IFNAR1<

    DOI： 10.4049/jimmunol.177.10.7059

  • TLR-dependent induction of IFN-β mediates host defense against Trypanosoma cruzi 査読 国際誌

    177 ( 10 )   7059 - 66   2006年11月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    <p>Host resistance to the intracellular protozoan parasite Trypanosoma cruzi depends on IFN-γ production by T cells and NK cells. However, the involvement of innate immunity in host resistance to T. cruzi remains unclear. In the present study, we investigated host defense against T. cruzi by focusing on innate immunity. Macrophages and dendritic cells (DCs) from MyD88 -/-TRIF-/- mice, in which TLR-dependent activation of innate immunity was abolished, were defective in the clearance of T. cruzi and showed impaired induction of TFN-β during T. cruzi infection. Neutralization of IFN-β in MyD88-/- macrophages led to enhanced T. cruzi growth. Cells from MyD88-/-IFNAR1-/- mice also showed impaired T. cruzi clearance. Furthermore, both MyD88 -/-TRIF-/- and MyD88-/-IFNAR1-/- mice were highly susceptible to in vivo T. cruzi infection, highlighting the involvement of innate immune responses in T. cruzi infection. We further analyzed the molecular mechanisms for the IFN-β-mediated antitrypanosomal innate immune responses. MyD88-/-TRIF-/- and MyD88 -/-IFNAR1<

    DOI： 10.4049/jimmunol.177.10.7059

  • IκBNS inhibits induction of a subset of toll-like receptor-dependent genes and limits inflammation 査読 国際誌

    24 ( 1 )   41 - 51   2006年1月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    <p>Toll-like receptor (TLR)-mediated immune responses are downregulated by several mechanisms that affect signaling pathways. However, it remains elusive how TLR-mediated gene expression is differentially modulated. Here, we show that IκBNS, a TLR-inducible nuclear IκB protein, negatively regulates induction of a subset of TLR-dependent genes through inhibition of NF-κB activity. IκBNS-deficient macrophages and dendritic cells show increased TLR-mediated expression of genes such as IL-6 and IL-12p40, which are induced late after TLR stimulation. In contrast, IκBNS-deficient cells showed normal induction of genes that are induced early or induced via IRF-3 activation. LPS stimulation of IκBNS-deficient macrophages prolonged NF-κB activity at the specific promoters, indicating that IκBNS mediates termination of NF-κB activity at selective gene promoters. Moreover, IκBNS-deficient mice are highly susceptible to LPS-induced endotoxin shock and intestinal inflammation. Thus, IκBNS regulates inflammatory responses by inhibiting the induction of a subset of TLR-dependent genes through modulation of NF-κB activity. © 2006 Elsevier Inc.</p>

    DOI： 10.1016/j.immuni.2005.11.004

  • IκBNS inhibits induction of a subset of toll-like receptor-dependent genes and limits inflammation 査読 国際誌

    24 ( 1 )   41 - 51   2006年1月

    　詳細を見る

    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    <p>Toll-like receptor (TLR)-mediated immune responses are downregulated by several mechanisms that affect signaling pathways. However, it remains elusive how TLR-mediated gene expression is differentially modulated. Here, we show that IκBNS, a TLR-inducible nuclear IκB protein, negatively regulates induction of a subset of TLR-dependent genes through inhibition of NF-κB activity. IκBNS-deficient macrophages and dendritic cells show increased TLR-mediated expression of genes such as IL-6 and IL-12p40, which are induced late after TLR stimulation. In contrast, IκBNS-deficient cells showed normal induction of genes that are induced early or induced via IRF-3 activation. LPS stimulation of IκBNS-deficient macrophages prolonged NF-κB activity at the specific promoters, indicating that IκBNS mediates termination of NF-κB activity at selective gene promoters. Moreover, IκBNS-deficient mice are highly susceptible to LPS-induced endotoxin shock and intestinal inflammation. Thus, IκBNS regulates inflammatory responses by inhibiting the induction of a subset of TLR-dependent genes through modulation of NF-κB activity. © 2006 Elsevier Inc.</p>

    DOI： 10.1016/j.immuni.2005.11.004

▼全件表示

講演・口頭発表等

▼全件表示

MISC

  • 無菌コモンマーモセットの作出

    井上 貴史, 植野 昌未, 野津 量子, 岡原 則夫, 岡橋 伸幸, 佐藤 賢哉, 上田 政広, 新 幸二, 諫山 純, 青戸 良賢, 川島 祐介, 菊池 理加, 黒滝 陽子, 峰重 隆幸, 圦本 晃海, 板谷 佳織, 田之上 大, 中畑 龍俊, 塩田 淳, 有田 誠, 本田 賢也, 佐々木 えりか

    無菌生物   52 ( 2 )   25 - 26   2022年12月   （ ISSN:0910-0903 ）

    　詳細を見る

    記述言語：日本語   出版者・発行元：日本無菌生物ノートバイオロジー学会  

    無菌霊長類を用いた腸内微生物叢研究の展開をめざして,我々は小型の霊長類種のコモンマーモセットにおいて無菌動物の作出とその研究応用のための技術開発を進めている.妊娠個体の準備からビニールアイソレータ内の無菌環境下での帝王切開による産仔獲得,人工哺育,育成までの一連の技術確立を進めて無菌マーモセットの作出を試みた.その結果,糞便の培養検査により生菌が検出されない無菌マーモセット個体の作出に成功し,最長で24ヵ月齢まで培養検査陰性の維持に至った.獲得したマーモセット個体では,糞便中の二次胆汁酸の欠如や,分泌型IgAの低濃度,糞便・血漿のプロテオーム解析での免疫関連のタンパク質の低発現,造影レントゲン検査のよる盲腸拡大が観察され,無菌動物としての特性が示唆された.今後は,作出した無菌マーモセットの繁殖を試みるとともに,作出技術を洗練させて研究利用のための安定供給体制を確立していきたい.(著者抄録)

  • 【腸内細菌と免疫、その最新情報】腸内細菌とTH1/TH2/CD8+T細胞免疫応答

    田之上 大, 新 幸二

    腸内細菌学雑誌   36 ( 1 )   13 - 20   2022年1月   （ ISSN:1343-0882 ）

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    記述言語：日本語   出版者・発行元：(公財)腸内細菌学会  

    T細胞は抗原特異的な免疫応答において中心的役割を担う免疫細胞であり、その分化・機能に腸内細菌が関与することが知られている。T細胞のうちαβT細胞受容体を発現するT細胞はCD4T細胞およびCD8T細胞に大別される。CD4T細胞のうちTH1細胞と呼ばれるサブセットは細胞内寄生細菌に対する免疫応答に重要であるとともに、その過剰な活性化は自己免疫疾患の発症・増悪に関与する。一方、TH2細胞サブセットは寄生虫感染防御応答に重要であるかたわら、花粉症や喘息などのアレルギー応答の増悪にも関与する。また、CD8T細胞は病原性細菌・ウイルスやがん免疫応答に重要な役割を担っている。この記事では、これらTH1、TH2およびCD8T細胞応答とその関連疾患に関与する腸内細菌を紹介する。(著者抄録)

共同研究・競争的資金等の研究課題

  • 健康・長寿をもたらす腸内細菌の解明

    研究課題/領域番号：23K27654  2023年4月 - 2027年3月

    科学研究費助成事業  基盤研究(B)

    新 幸二

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    資金種別：科研費

    百寿者の便中に特異的に存在していた二次胆汁酸の宿主への作用について受容体の同定、シグナル伝達経路の解明を行う。同時に、百寿者由来腸内細菌株を使用して、腸内細菌による新規コレステロールやステロイドホルモンの代謝経路の解明を行い、腸内細菌を用いた疾患予防法の開発および健康長寿社会の実現につなげることを目的として研究を行う。

    CiNii Research