Updated on 2025/01/21

Information

 

写真a

 
matsuo ryu
 
Organization
Faculty of Medical Sciences Department of Basic Medicine Professor
Faculty of Medical Sciences Center for Cohort Studies(Concurrent)
Graduate School of Medical Sciences Department of Medicine(Concurrent)
Graduate School of Medical Sciences Department of Health Care Administration and Management(Concurrent)
Title
Professor
Contact information
メールアドレス
Tel
0926426960
Profile
1.急性期脳卒中の疾患コホート研究:福岡脳卒中データベース研究(Fukuoka Stroke Registry: FSR)を用いて、脳卒中の病態解明に関わる研究を行っている。 2.急性期脳卒中の遺伝子、バイオマーカー研究:急性期脳卒中において、その病態に関わる遺伝子やバイオマーカーの研究を行っている。 3.急性期脳卒中の診療実態の可視化に関する研究:急性期脳卒中の医療における機能予後を含めた、医療の質、医療経済学的な評価の研究を行っている。 4.レセプト分析研究:NDBデータ、介護データ等を用いて医療の可視化と医療政策による還元をめざした研究を行っている。

Degree

  • M.D.

Research History

  • Kyushu University Associate Professor

    2020.5 - 2023.3

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Research Interests・Research Keywords

  • Research theme:Disability-adjusted Long-term Prognosis in Ischemic Stroke Patients Using Stroke Registry

    Keyword:Stroke, QOL, DALY, cohort

    Research period: 2017.4

  • Research theme:Genetic factor in Stroke

    Keyword:genetics, stroke, SNP

    Research period: 2015.4

  • Research theme:Research for biomarkers in stroke

    Keyword:biomarker, stroke

    Research period: 2015.4

  • Research theme:Association between stroke and air pollution

    Keyword:stroke, air pollution

    Research period: 2015.4

  • Research theme:Stroke and health economics

    Keyword:Stroke, health economics

    Research period: 2015.4

  • Research theme:Epidemiology in Stroke

    Keyword:stroke, epidemiology, cohort

    Research period: 2012.4

Awards

  • 第9回ふくおか「臨床医学研究賞」

    2015.3   医療・介護・教育研究財団  

  • 第5回福岡県医学会総会 ポスター優秀賞

    2013.2   福岡県医学会  

  • 第54回日本老年医学会学術集会 最優秀演題賞

    2012.6   第54回日本老年医学会学術集会  

Papers

  • Association between abdominal adiposity and clinical outcomes in patients with acute ischemic stroke. Reviewed International journal

    Kayo Wakisaka, Ryu Matsuo, Fumi Irie, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono

    PloS one   19 ( 1 )   e0296833   2024.1   ISSN:1932-6203

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    BACKGROUND: It is unclear whether abdominal adiposity has an additional effect on post-stroke outcomes. This study aimed to determine whether waist circumference (WC) is independently associated with clinical outcomes after acute ischemic stroke. METHODS: We enrolled patients with acute ischemic stroke from a multicenter hospital-based stroke registry in Fukuoka, Japan. We measured WC on admission and categorized patients into four groups (Q1-Q4) according to the quartiles in females and males. The clinical outcomes were poor functional outcome (modified Rankin scale score 2-6) and death from any cause. Logistic regression analysis was performed to estimate the odds ratio and 95% confidence interval of the outcomes of interest after adjusting for potential confounding factors, including body mass index (BMI). RESULTS: A total of 11,989 patients (70.3±12.2 years, females: 36.1%) were included in the analysis. The risk of poor functional outcome significantly decreased for Q2-Q4 (vs. Q1) at discharge and Q2-Q3 (vs. Q1) at 3 months, even after adjusting for potential confounders, including BMI. In contrast, adjustment of BMI eliminated the significant association between WC and all-cause death at discharge and 3 months. The association between high WC and favorable functional outcome was not affected by fasting insulin levels or homeostatic model assessment for insulin resistance and was only found in patients without diabetes (P = 0.02 for heterogeneity). CONCLUSIONS: These findings suggest that abdominal adiposity has an additional impact on post-stroke functional outcome, independent of body weight and insulin action.

    DOI: 10.1371/journal.pone.0296833

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  • Body temperature in the acute phase and clinical outcomes after acute ischemic stroke. Reviewed International journal

    Satomi Mezuki, Ryu Matsuo, Fumi Irie, Yuji Shono, Takahiro Kuwashiro, Hiroshi Sugimori, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono

    PloS one   19 ( 1 )   e0296639   2024.1   ISSN:1932-6203

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    BACKGROUND: This study aimed to examine whether post-stroke early body temperature is associated with neurological damage in the acute phase and functional outcomes at three months. METHODS: We included 7,177 patients with acute ischemic stroke within 24 h of onset. Axillary temperature was measured daily in the morning for seven days. Mean body temperature was grouped into five quintiles (Q1: 35.1‒36.5°C, Q2: 36.5‒36.7°C, Q3: 36.7‒36.8°C, Q4: 36.8‒37.1°C, and Q5: 37.1‒39.1°C). Clinical outcomes included neurological improvement during hospitalization and poor functional outcome (modified Rankin scale score, 3-6) at three months. A logistic regression analysis was performed to evaluate the association between body temperature and clinical outcomes. RESULTS: The patient's mean (SD) age was 70.6 (12.3) years, and 35.7% of patients were women. Mean body temperature was significantly associated with less neurological improvement from Q2 (odds ratios [95% confidence interval], 0.77 [0.65-0.99] vs. Q1) to Q5 (0.33 [0.28-0.40], P for trend <0.001) even after adjusting for potential confounders, including baseline neurological severity, C-reactive protein levels, and post-stroke acute infections. The multivariable-adjusted risk of poor functional outcome linearly increased from Q2 (1.36 [1.03-1.79]) to Q5 (6.44 [5.19-8.96], P for trend <0.001). These associations were maintained even in the analyses excluding patients with acute infectious diseases. Multivariable-adjusted risk of poor functional outcome was higher in patients with early body temperature elevation on days 1-3 and with longer duration with body temperature >37.0°C. CONCLUSIONS: Post-stroke early high body temperature is independently associated with unfavorable outcomes following acute ischemic stroke.

    DOI: 10.1371/journal.pone.0296639

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  • Registry Studies of Stroke in Japan.

    Ryu Matsuo

    Journal of atherosclerosis and thrombosis   30 ( 9 )   1095 - 1103   2023.9   ISSN:13403478 eISSN:18803873

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japan Atherosclerosis Society  

    <p>Recently, the Cerebrovascular and Cardiovascular Disease Control Act was enacted, for which it was necessary to establish a comprehensive and accurate nationwide database and promote rational and economical stroke countermeasures in Japan, thus serving the public interest. Among the many studies on stroke registries, the Fukuoka Stroke Registry, a regional cohort, provides highly accurate information, and the Japanese Stroke Data Bank, a nationwide cohort, is highly comprehensive. The findings of these studies have contributed to the construction of evidence and the establishment of guidelines for stroke management. In the Nationwide survey of Acute Stroke care capacity for Proper dEsignation of Comprehensive stroke CenTer in Japan, research on improving the quality of medical care to close the gap between guidelines and clinical practice was performed using electronic medical records. This has enabled the recommendation of medical policies in Japan by visualizing medical care. In the era of healthcare big data and the Internet of Things, plenty of healthcare information is automatically recorded electronically and incorporated into databases. Thus, the establishment of stroke registries with the effective utilization of these electronic records can contribute to the development of stroke care.</p>

    DOI: 10.5551/jat.RV22008

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  • Association between decreases in serum uric acid levels and unfavorable outcomes after ischemic stroke: A multicenter hospital-based observational study. Reviewed International journal

    Kuniyuki Nakamura, Kana Ueki, Ryu Matsuo, Takuya Kiyohara, Fumi Irie, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono

    PloS one   18 ( 6 )   e0287721   2023.6   ISSN:1932-6203 eISSN:19326203

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    BACKGROUND: The association between clinical outcomes in ischemic stroke patients and decreases in serum uric acid levels, which often occur during the acute phase, remains unknown. Herein, we aimed to investigate the association using a large-scale, multicenter stroke registry. METHODS: We analyzed 4,621 acute ischemic stroke patients enrolled in the Fukuoka Stroke Registry between June 2007 and September 2019 whose uric acid levels were measured at least twice during hospitalization (including on admission). The study outcomes were poor functional outcome (modified Rankin Scale score ≥3) and functional dependence (modified Rankin Scale score 3-5) at 3 months after stroke onset. Changes in uric acid levels after admission were evaluated using a decrease rate that was classified into 4 sex-specific grades ranging from G1 (no change/increase after admission) to G4 (most decreased). Multivariable logistic regression analyses were used to assess the associations between decreases in uric acid levels and the outcomes. RESULTS: The frequencies of the poor functional outcome and functional dependence were lowest in G1 and highest in G4. The odds ratios (95% confidence intervals) of G4 were significantly higher for poor functional outcome (2.66 [2.05-3.44]) and functional dependence (2.61 [2.00-3.42]) when compared with G1 after adjusting for confounding factors. We observed no heterogeneity in results for subgroups categorized according to age, sex, stroke subtype, neurological severity, chronic kidney disease, or uric acid level on admission. CONCLUSIONS: Decreases in serum uric acid levels were independently associated with unfavorable outcomes after acute ischemic stroke.

    DOI: 10.1371/journal.pone.0287721

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  • Decreased Estimated Glomerular Filtration Rate and Proteinuria and Long-Term Outcomes After Ischemic Stroke: A Longitudinal Observational Cohort Study. Reviewed International journal

    Kana Ueki, Ryu Matsuo, Takahiro Kuwashiro, Fumi Irie, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono

    Stroke   54 ( 5 )   1268 - 1277   2023.5   ISSN:0039-2499 eISSN:1524-4628

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    BACKGROUND: It remains unclear how chronic kidney disease and its underlying pathological conditions, kidney dysfunction, and kidney damage, are associated with cardiovascular outcomes. This study aimed to determine whether kidney dysfunction (ie, decreased estimated glomerular filtration rate), kidney damage (ie, proteinuria), or both are associated with the long-term outcomes after ischemic stroke. METHODS: A total of 12 576 patients (mean age, 73.0±12.6 years; 41.3% women) with ischemic stroke who were registered in a hospital-based multicenter registry, Fukuoka Stroke Registry, between June 2007 and September 2019, were prospectively followed up after stroke onset. Kidney function was assessed by estimated glomerular filtration rate and categorized into G1: ≥60 mL/(min·1.73 m2), G2: 45-59 mL/(min·1.73 m2), and G3: <45 mL/(min·1.73 m2). Kidney damage was evaluated by proteinuria using a urine dipstick test and classified into P1: -, P2: ±/1+, and P3: ≥2+. Hazard ratios and 95% CI for events of interest were estimated by a Cox proportional hazards model. Long-term outcomes included recurrence of stroke and all-cause death. RESULTS: During the median follow-up of 4.3 years (interquartile range, 2.1-7.3 years), 2481 patients had recurrent stroke (48.0/1000 patient-years) and 4032 patients died (67.3/1000 patient-years). Chronic kidney disease was independently associated with increased risks of stroke recurrence and all-cause death even after adjustment for multiple confounding factors, including traditional cardiovascular risk factors. Both estimated glomerular filtration rate and proteinuria were independently associated with increased risks of stroke recurrence (multivariable-adjusted hazard ratio [95% CI], G3: 1.22 [1.09-1.37] versus G1, P3: 1.25 [1.07-1.46] versus P1) and death (G3: 1.45 [1.33-1.57] versus G1, P3: 1.62 [1.45-1.81] versus P1). In subgroup analyses, effect modifications were found in the association of proteinuria with death by age and stroke subtype. CONCLUSIONS: Kidney dysfunction and kidney damage were independently, but differently, associated with increased risks of recurrent stroke and all-cause death.

    DOI: 10.1161/STROKEAHA.122.040958

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  • Non-linear association between body weight and functional outcome after acute ischemic stroke. Reviewed International journal

    Kayo Wakisaka, Ryu Matsuo, Koutarou Matsumoto, Yasunobu Nohara, Fumi Irie, Yoshinobu Wakisaka, Tetsuro Ago, Naoki Nakashima, Masahiro Kamouchi, Takanari Kitazono

    Scientific reports   13 ( 1 )   8697 - 8697   2023.5   ISSN:2045-2322

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    This study aimed to determine whether body weight is associated with functional outcome after acute ischemic stroke. We measured the body mass index (BMI) and assessed clinical outcomes in patients with acute ischemic stroke. The BMI was categorized into underweight (< 18.5 kg/m2), normal weight (18.5-22.9 kg/m2), overweight (23.0-24.9 kg/m2), and obesity (≥ 25.0 kg/m2). The association between BMI and a poor functional outcome (modified Rankin Scale [mRS] score: 3-6) was evaluated. We included 11,749 patients with acute ischemic stroke (70.3 ± 12.2 years, 36.1% women). The risk of a 3-month poor functional outcome was higher for underweight, lower for overweight, and did not change for obesity in reference to a normal weight even after adjusting for covariates by logistic regression analysis. Restricted cubic splines and SHapley Additive exPlanation values in eXtreme Gradient Boosting model also showed non-linear relationships. Associations between BMI and a poor functional outcome were maintained even after excluding death (mRS score: 3-5) or including mild disability (mRS score: 2-6) as the outcome. The associations were strong in older patients, non-diabetic patients, and patients with mild stroke. Body weight has a non-linear relationship with the risk of a poor functional outcome after acute ischemic stroke.

    DOI: 10.1038/s41598-023-35894-y

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  • Modification of the effects of age on clinical outcomes through management of lifestyle-related factors in patients with acute ischemic stroke. Reviewed International journal

    Yuichiro Ohya, Ryu Matsuo, Noriko Sato, Fumi Irie, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono

    Journal of the neurological sciences   446   120589 - 120589   2023.3   ISSN:0022-510X eISSN:1878-5883

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    BACKGROUND AND PURPOSE: This study examined the association between age and clinical outcomes after ischemic stroke, and whether the effect of age on post-stroke outcomes can be modified by various factors. METHODS: We included 12,171 patients with acute ischemic stroke, who were functionally independent before stroke onset, in a multicenter hospital-based study conducted in Fukuoka, Japan. Patients were categorized into six groups according to age: ≤ 45, 46-55, 56-65, 66-75, 76-85, and > 85 years. Logistic regression analysis was performed to estimate an odds ratio for poor functional outcome (modified Rankin scale score of 3-6 at 3 months) for each age group. Interaction effects of age and various factors were analyzed using a multivariable model. RESULTS: The mean age of the patients was 70.3 ± 12.2 years, and 63.9% were men. Neurological deficits at onset were more severe in the older age groups. The odds ratio of poor functional outcome linearly increased (P for trend <0.001), even after adjusting for potential confounders. Sex, body mass index, hypertension, and diabetes mellitus significantly modified the effect of age on the outcome (P < 0.05). The unfavorable effect of older age was greater in female patients and those with low body weight, whereas the protective effect of younger age was smaller in patients with hypertension or diabetes mellitus. CONCLUSIONS: Functional outcome worsened with age in patients with acute ischemic stroke, especially in females and those with low body weight, hypertension, or hyperglycemia.

    DOI: 10.1016/j.jns.2023.120589

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  • Factors associated with health-related quality of life in long-stay inpatients with chronic schizophrenia Reviewed

    Hiroko Oyama, Kouichi Oda, Ryu Matsuo

    Psychiatry and Clinical Neurosciences Reports   1 ( 3 )   e42   2022.9

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  • Causes of ischemic stroke in young adults versus non-young adults: A multicenter hospital-based observational study. Reviewed International journal

    Yuichiro Ohya, Ryu Matsuo, Noriko Sato, Fumi Irie, Kuniyuki Nakamura, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono

    PloS one   17 ( 7 )   e0268481   2022.7

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    BACKGROUND: Very few comparative studies have focused on the differences in the causes of ischemic stroke between young adults and non-young adults. This study was performed to determine what causes of ischemic stroke are more important in young adults than in non-young adults using a large-scale multicenter hospital-based stroke registry in Fukuoka, Japan. METHODS AND RESULTS: We investigated data on 15,860 consecutive patients aged ≥18 years with acute ischemic stroke (mean age: 73.5 ± 12.4 years, 58.2% men) who were hospitalized between 2007 and 2019. In total, 779 patients were categorized as young adults (≤50 years of age). Although vascular risk factors, including hypertension, diabetes mellitus, and dyslipidemia, were less frequent in young adults than in non-young adults, the prevalence of diabetes mellitus and dyslipidemia in young adults aged >40 years were comparable to those of non-young adults. Lifestyle-related risk factors such as smoking, drinking, and obesity were more frequent in young adults than in non-young adults. As young adults became older, the proportions of cardioembolism and stroke of other determined etiologies decreased, but those of large-artery atherosclerosis and small-vessel occlusion increased. Some embolic sources (high-risk sources: arterial myxoma, dilated cardiomyopathy, and intracardiac thrombus; medium-risk sources: atrial septal defect, nonbacterial thrombotic endocarditis, patent foramen ovale, and left ventricular hypokinesis) and uncommon causes (vascular diseases: reversible cerebral vasoconstriction syndrome, moyamoya disease, other vascular causes, arterial dissection, and cerebral venous thrombosis; hematologic diseases: antiphospholipid syndrome and protein S deficiency) were more prevalent in young adults than in non-young adults, and these trends decreased with age. CONCLUSIONS: Certain embolic sources and uncommon causes may be etiologically important causes of ischemic stroke in young adults. However, the contribution of conventional vascular risk factors and lifestyle-related risk factors is not negligible with advancing age, even in young adults.

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  • Day-by-Day Blood Pressure Variability in the Subacute Stage of Ischemic Stroke and Long-Term Recurrence. Reviewed International journal

    Kenji Fukuda, Ryu Matsuo, Masahiro Kamouchi, Fumi Kiyuna, Noriko Sato, Kuniyuki Nakamura, Jun Hata, Yoshinobu Wakisaka, Tetsuro Ago, Tsutomu Imaizumi, Hisashi Kai, Takanari Kitazono

    Stroke   53 ( 1 )   70 - 78   2022.1   ISSN:0039-2499 eISSN:1524-4628

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    BACKGROUND AND PURPOSE: This study aimed to determine whether variability of day-by-day blood pressure (BP) during the subacute stage of acute ischemic stroke is predictive of long-term stroke recurrence. METHODS: We analyzed 7665 patients (mean±SD age: 72.9±13.1 years; women: 42.4%) hospitalized for first-ever ischemic stroke in 7 stroke centers in Fukuoka, Japan, from June 2007 to November 2018. BP was measured daily during the subacute stage (4-10 days after onset). Its mean and coefficient of variation (CV) values were calculated and divided into 4 groups according to the quartiles of these BP parameters. Patients were prospectively followed up for recurrent stroke or all-cause death. The cumulative event rate was calculated with the Kaplan-Meier method. We estimated the hazard ratios and 95% confidence intervals of the events of interest after adjusting for potential confounders and mean BP values using Cox proportional hazards models. The Fine-Gray model was also used to account for the competing risk of death. RESULTS: With a mean (±SD) follow-up duration of 3.9±3.2 years, the rates of recurrent stroke and all-cause death were 3.9 and 9.9 per 100 patient-years, respectively. The cumulative event rates of recurrent stroke and all-cause death increased with increasing CVs of systolic BP and diastolic BP. The systolic BP CV was significantly associated with an increased risk of recurrent stroke after adjusting for multiple confounders and mean BP (hazard ratio [95% CI] for fourth quartile versus first quartile, 1.26 [1.05-1.50]); the risk of recurrent stroke also increased with an increasing systolic BP CV for nonfatal strokes (1.26 [1.05-1.51]) and when death was regarded as a competing risk (1.21 [1.02-1.45]). Similar associations were observed for the diastolic BP CV. CONCLUSIONS: Day-by-day variability of BP during the subacute stage of acute ischemic stroke was associated with an increased long-term risk of recurrent stroke.

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  • Sex Differences in the Risk of 30-Day Death After Acute Ischemic Stroke. Reviewed International journal

    Fumi Irie, Ryu Matsuo, Kuniyuki Nakamura, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono

    Neurology. Clinical practice   11 ( 6 )   e809-e816   2021.12

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    DOI: 10.1212/CPJ.0000000000001087

  • β-Cell Function and Clinical Outcome in Nondiabetic Patients With Acute Ischemic Stroke. Reviewed International journal

    52 ( 8 )   2621 - 2628   2021.8

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    BACKGROUND AND PURPOSE: Little is known about how β-cell dysfunction affects clinical outcome after ischemic stroke. We examined whether β-cell function is associated with clinical outcome after acute ischemic stroke and if so, whether insulin resistance influences this association in a prospective study of patients with acute stroke. METHODS: A total of 3590 nondiabetic patients with acute ischemic stroke (mean age, 71 years) were followed up for 3 months. β-Cell function was assessed using the homeostasis model assessment for β-cell function (HOMA-β). Study outcomes were poor functional outcome (modified Rankin Scale score, 3–6) and stroke recurrence at 3 months after stroke onset and neurological deterioration (≥2-point increase in the National Institutes of Health Stroke Scale score) at discharge. Logistic regression analysis was used to evaluate the association between quintile levels of serum HOMA-β and clinical outcomes. RESULTS: The age- and sex-adjusted odds ratios for poor functional outcome and neurological deterioration increased significantly with decreasing HOMA-β levels (P for trend, <0.001 and 0.001, respectively). These associations became more prominent after adjustment for HOMA-insulin resistance and were substantially unchanged even after further adjustment for other confounders, namely, body mass index, dyslipidemia, hypertension, estimated glomerular filtration rate, stroke subtype, National Institutes of Health Stroke Scale score on admission, and reperfusion therapy (odds ratio [95&#37; CI] for the first versus fifth quintile of HOMA-β, 3.30 [2.15–5.08] for poor functional outcome and 10.69 [4.99–22.90] for neurological deterioration). Such associations were not observed for stroke recurrence. In stratified analysis for the combination of HOMA-β and HOMA-insulin resistance levels, lower HOMA-β and higher HOMA-insulin resistance levels were independently associated with increased risks of poor functional outcome and neurological deterioration. CONCLUSIONS: Our findings suggest that β-cell dysfunction is significantly associated with poor short-term clinical outcome independently of insulin resistance in nondiabetic patients with acute ischemic stroke.

    DOI: 10.1161/STROKEAHA.120.031392

  • Anticoagulation and Risk of Stroke Recurrence in Patients with Embolic Stroke of Undetermined Source Having No Potential Source of Embolism. Reviewed International journal

    Noriko Sato, Ryu Matsuo, Fumi Kiyuna, Kuniyuki Nakamura, Jun Hata, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono

    Cerebrovascular diseases (Basel, Switzerland)   49 ( 6 )   601 - 608   2020.12

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    DOI: 10.1159/000510773

  • Smoking Status and Functional Outcomes After Acute Ischemic Stroke. Reviewed International journal

    Ryu Matsuo, Tetsuro Ago, Fumi Kiyuna, Noriko Sato, Kuniyuki Nakamura, Junya Kuroda, Yoshinobu Wakisaka, Takanari Kitazono

    Stroke   51 ( 3 )   846 - 852   2020.3

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    DOI: 10.1161/STROKEAHA.119.027230

  • Insulin resistance and clinical outcomes after acute ischemic stroke Reviewed

    Tetsuro Ago, Ryu Matsuo, Jun Hata, Yoshinobu Wakisaka, Junya Kuroda, Takanari Kitazono, Masahiro Kamouchi

    Neurology   90 ( 17 )   E1470 - E1477   2018.4

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    DOI: 10.1212/WNL.0000000000005358

  • Association between onset-to-door time and clinical outcomes after ischemic stroke Reviewed

    Ryu Matsuo, Yuko Yamaguchi, Tomonaga Matsushita, Jun Hata, Fumi Kiyuna, Kenji Fukuda, Yoshinobu Wakisaka, Junya Kuroda, Tetsuro Ago, Takanari Kitazono, Masahiro Kamouchi, Takao Ishitsuka, Setsuro Ibayashi, Kenji Kusuda, Kenichiro Fujii, Tetsuhiko Nagao, Yasushi Okada, Masahiro Yasaka, Hiroaki Ooboshi, Katsumi Irie, Tsuyoshi Omae, Kazunori Toyoda, Hiroshi Nakane, Hiroshi Sugimori, Shuji Arakawa, Jiro Kitayama, Shigeru Fujimoto, Shoji Arihiro, Yoshihisa Fukushima

    Stroke   48 ( 11 )   3049 - 3056   2017.11

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    DOI: 10.1161/STROKEAHA.117.018132

  • Timing of anticoagulant therapy after acute ischemic stroke Reviewed

    Ryu Matsuo, Masahiro Kamouchi

    Circulation Journal   81 ( 2 )   151 - 152   2017.1

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    DOI: 10.1253/circj.CJ-16-1287

  • Short-Term Exposure to Fine Particulate Matter and Risk of Ischemic Stroke Reviewed

    Ryu Matsuo, Takehiro Michikawa, Kayo Ueda, Tetsuro Ago, Hiroshi Nitta, Takanari Kitazono, Masahiro Kamouchi

    Stroke   47 ( 12 )   3032 - 3034   2016.12

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    DOI: 10.1161/STROKEAHA.116.015303

  • Plasma C-reactive protein and clinical outcomes after acute ischemic stroke A prospective observational study Reviewed

    Ryu Matsuo, Tetsuro Ago, Jun Hata, Yoshinobu Wakisaka, Junya Kuroda, Takahiro Kuwashiro, Takanari Kitazono, Masahiro Kamouchi

    PloS one   11 ( 6 )   2016.6

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    DOI: 10.1371/journal.pone.0156790

  • Intravenous Thrombolysis with Recombinant Tissue Plasminogen Activator for Ischemic Stroke Patients over 80 Years Old: The Fukuoka Stroke Registry Reviewed International journal

    Matsuo, Ryu; Kamouchi, Masahiro; Fukuda, Haruhisa; Hata, Jun; Wakisaka, Yoshinobu; Kuroda, Junya; Ago, Tetsuro; Kitazono, Takanari

    PLOS ONE   9 ( 10 )   2014.10

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    DOI: 10.1371/journal.pone.0110444

  • Thrombolytic therapy with intravenous recombinant tissue plasminogen activator in Japanese older patients with acute ischemic stroke: Fukuoka Stroke Registry Reviewed International journal

    Matsuo, Ryu, Kamouchi, Masahiro, Ago, Tetsuro, Hata, Jun, Shono, Yuji, Kuroda, Junya, Wakisaka, Yoshinobu, Sugimori, Hiroshi, Kitazono, Takanari

    GERIATRICS & GERONTOLOGY INTERNATIONAL   14 ( 4 )   954 - 959   2014.10

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    DOI: 10.1111/ggi.12205

  • Impact of the 1425G/A Polymorphism of PRKCH on the Recurrence of Ischemic Stroke: Fukuoka Stroke Registry Reviewed International journal

    Matsuo, Ryu, Ago, Tetsuro, Hata, Jun, Kuroda, Junya, Wakisaka, Yoshinobu, Sugimori, Hiroshi, Kitazono, Takanari, Kamouchi, Masahiro

    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES   23 ( 6 )   1356 - 1361   2014.7

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    DOI: 10.1016/j.jstrokecerebrovasdis.2013.11.011

  • Clinical significance of plasma VEGF value in ischemic stroke - research for biomarkers in ischemic stroke (REBIOS) study Reviewed International journal

    Matsuo, Ryu, Ago, Tetsuro, Kamouchi, Masahiro, Kuroda, Junya, Kuwashiro, Takahiro, Hata, Jun, Sugimori, Hiroshi, Fukuda, Kenji, Gotoh, Seiji, Makihara, Noriko, Fukuhara, Masayo, Awano, Hideto, Isomura, Tetsu, Suzuki, Kazuo, Yasaka, Masahiro, Okada, Yasushi, Kiyohara, Yutaka, Kitazono, Takanari

    BMC NEUROLOGY   13   2013.4

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  • Association between pulse pressure and risk of acute kidney injury after intracerebral hemorrhage

    Ohya, Y; Irie, F; Nakamura, K; Kiyohara, T; Wakisaka, Y; Ago, T; Matsuo, R; Kamouchi, M; Kitazono, T

    HYPERTENSION RESEARCH   2024.12   ISSN:0916-9636 eISSN:1348-4214

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    The aim of this study was to determine whether pulse pressure (PP), an indicator of arterial stiffness, was independently associated with the risk of acute kidney injury (AKI) following intracerebral hemorrhage (ICH). We enrolled patients with acute ICH from a multicenter stroke registry in Fukuoka, Japan, from June 2007 to September 2019. The mean PP, measured three times on the third day after admission, was categorized into three groups based on tertiles: G1 < 54 mmHg, G2 54–64 mmHg, and G3 ≥ 65 mmHg. AKI was defined as an increase of ≥0.3 mg/dL or ≥150% in serum creatinine levels above baseline during hospitalization. The associations between PP and AKI were evaluated using logistic regression analyses. Overall, 1512 patients with acute ICH (mean age: 69.8 ± 13.5 years; 56.4% men) were included in the analysis. The incidence rates of AKI were 5.6%, 11.0%, and 13.2% in groups G1, G2, and G3, respectively. The odds ratio (95% confidence interval) of AKI was significantly elevated in G2 (1.77 [1.07–2.91]) and G3 (1.82 [1.10–3.03]) compared to G1, even after adjusting for initial systolic blood pressure (SBP) values on admission and subsequent SBP reductions. This significant association was observed in patients with an initial SBP < 200 mmHg (P for heterogeneity, 0.045) and those receiving intravenous antihypertensive therapy in the acute stage (P for heterogeneity, 0.03). High PP should be recognized as a novel potential risk factor for AKI following ICH. (Figure presented.)

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  • Feasibility and Inter-rater Reliability of the Japanese Version of the Intensive Care Unit Mobility Scale Reviewed

    Daisetsu Yasumura, Hajime Katsukawa, Ryu Matsuo, Reo Kawano, Shunsuke Taito, Keibun Liu, Carol Hodgson

    Cureus   16 ( 4 )   e59135   2024.4   ISSN:2168-8184 eISSN:2168-8184

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  • Effect of smoking status on clinical outcomes after reperfusion therapy for acute ischemic stroke Reviewed

    Fumi Irie, Ryu Matsuo, Satomi Mezuki, Yoshinobu Wakisaka, Masahiro Kamouchi, Takanari Kitazono, Tetsuro Ago, Takao Ishitsuka, Setsuro Ibayashi, Kenji Kusuda, Kenichiro Fujii, Tetsuhiko Nagao, Yasushi Okada, Masahiro Yasaka, Hiroaki Ooboshi, Takanari Kitazono, Katsumi Irie, Tsuyoshi Omae, Kazunori Toyoda, Hiroshi Nakane, Masahiro Kamouchi, Hiroshi Sugimori, Shuji Arakawa, Kenji Fukuda, Tetsuro Ago, Jiro Kitayama, Shigeru Fujimoto, Shoji Arihiro, Junya Kuroda, Yoshinobu Wakisaka, Yoshihisa Fukushima, Ryu Matsuo, Fumi Irie, Kuniyuki Nakamura, Takuya Kiyohara

    Scientific Reports   14 ( 1 )   9290   2024.4   ISSN:2045-2322 eISSN:2045-2322

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    Abstract

    Smoking has detrimental effects on the cardiovascular system; however, some studies have reported better clinical outcomes after thrombolysis for ischemic stroke in smokers than in nonsmokers, a phenomenon known as the smoking paradox. Therefore, this study aimed to examine the smoking paradox in patients with ischemic stroke receiving reperfusion therapy. Data were collected from a multicenter hospital-based acute stroke registry in Fukuoka, Japan. The 1148 study patients were categorized into current and noncurrent smokers. The association between smoking and clinical outcomes, including neurological improvement (≥ 4-point decrease in the National Institutes of Health Stroke Scale during hospitalization or 0 points at discharge) and good functional outcomes (modified Rankin Scale score of 0–2) at 3 months, was evaluated using logistic regression analysis and propensity score-matched analysis. Among the participants, 231 (20.1%) were current smokers. The odds ratios (ORs) of favorable outcomes after adjusting for potential confounders were not significantly increased in current smokers (OR 0.85, 95% confidence interval [CI] 0.60–1.22 for neurological improvement; OR 0.95, 95% CI 0.65–1.38 for good functional outcome). No significant association was found in the propensity score-matched cohorts. Smoking cessation is strongly recommended since current smoking was not associated with better outcomes after reperfusion therapy.

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    Other Link: https://www.nature.com/articles/s41598-024-59508-3

  • Predictive Performance of Machine Learning–Based Models for Poststroke Clinical Outcomes in Comparison With Conventional Prognostic Scores: Multicenter, Hospital-Based Observational Study Reviewed

    Fumi Irie, Koutarou Matsumoto, Ryu Matsuo, Yasunobu Nohara, Yoshinobu Wakisaka, Tetsuro Ago, Naoki Nakashima, Takanari Kitazono, Masahiro Kamouchi

    JMIR AI   3   e46840 - e46840   2024.1   eISSN:2817-1705

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    Background

    Although machine learning is a promising tool for making prognoses, the performance of machine learning in predicting outcomes after stroke remains to be examined.

    Objective

    This study aims to examine how much data-driven models with machine learning improve predictive performance for poststroke outcomes compared with conventional stroke prognostic scores and to elucidate how explanatory variables in machine learning–based models differ from the items of the stroke prognostic scores.

    Methods

    We used data from 10,513 patients who were registered in a multicenter prospective stroke registry in Japan between 2007 and 2017. The outcomes were poor functional outcome (modified Rankin Scale score &gt;2) and death at 3 months after stroke. Machine learning–based models were developed using all variables with regularization methods, random forests, or boosted trees. We selected 3 stroke prognostic scores, namely, ASTRAL (Acute Stroke Registry and Analysis of Lausanne), PLAN (preadmission comorbidities, level of consciousness, age, neurologic deficit), and iScore (Ischemic Stroke Predictive Risk Score) for comparison. Item-based regression models were developed using the items of these 3 scores. The model performance was assessed in terms of discrimination and calibration. To compare the predictive performance of the data-driven model with that of the item-based model, we performed internal validation after random splits of identical populations into 80% of patients as a training set and 20% of patients as a test set; the models were developed in the training set and were validated in the test set. We evaluated the contribution of each variable to the models and compared the predictors used in the machine learning–based models with the items of the stroke prognostic scores.

    Results

    The mean age of the study patients was 73.0 (SD 12.5) years, and 59.1% (6209/10,513) of them were men. The area under the receiver operating characteristic curves and the area under the precision-recall curves for predicting poststroke outcomes were higher for machine learning–based models than for item-based models in identical populations after random splits. Machine learning–based models also performed better than item-based models in terms of the Brier score. Machine learning–based models used different explanatory variables, such as laboratory data, from the items of the conventional stroke prognostic scores. Including these data in the machine learning–based models as explanatory variables improved performance in predicting outcomes after stroke, especially poststroke death.

    Conclusions

    Machine learning–based models performed better in predicting poststroke outcomes than regression models using the items of conventional stroke prognostic scores, although they required additional variables, such as laboratory data, to attain improved performance. Further studies are warranted to validate the usefulness of machine learning in clinical settings.

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  • Database Research for Stroke

    MATSUO Ryu

    114 ( 3 )   99 - 108   2023.9   ISSN:0016254X

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    Database research for stroke have contributed to the development of evidence and the establishment of guidelines for stroke management. In Japan, the Fukuoka stroke registry, a regional cohort̶which provides highly accurate data̶and the Japan stroke data bank̶which includes nationwide comprehensive data̶have been collected through individual questionnaires (as revealed by a conventional epidemiological study). Recently, studies using existing data, such as insurance claims data, have become popular (as revealed by a data-driven epidemiological study). The nationwide survey of acute stroke care capacity for proper designation of comprehensive stroke center in Japan (J-ASPECT study) is assessing the quality of stroke care to close the gap between guidelines and clinical practice using data from the Diagnosis Procedure Combination, developed as a measurement tool to standardize, evaluate, and improve the quality of healthcare in Japan and to clarify the content of acute-phase hospital care. The National Database of Health Insurance Claims and Specific Health Checkups is the largest database globally that facilitates the visualization of stroke care in Japan. Large-scale real-world databases̶such as the Registry of the Canadian Stroke Network and Riks-Stroke̶have been constructed worldwide. In both cases, data are collected without obtaining consent and are linked to existing data, such as administrative data. However, the environment for database research has not been sufficiently developed from the perspective of personal information protection and research ethics in Japan. In this era of medical big data, extensive medical information is automatically recorded electronically. Medical DX (digital transformation) aims to enable the appropriate use of such medical information and linking it with existing data̶such as insurance claims data and administrative data. A large database research utilizing electronic information can change the future of stroke care.

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  • Sex Differences in Long-Term Functional Decline after Ischemic Stroke: A Longitudinal Observational Study from the Fukuoka Stroke Registry. Reviewed International journal

    Fumi Irie, Ryu Matsuo, Kuniyuki Nakamura, Yoshinobu Wakisaka, Tetsuro Ago, Takanari Kitazono, Masahiro Kamouchi

    Cerebrovascular diseases (Basel, Switzerland)   52 ( 4 )   1 - 8   2023.2   ISSN:1015-9770 eISSN:1421-9786

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    INTRODUCTION: Data on sex differences in poststroke functional status for a period longer than 1 year based on large cohorts are sparse. This study aimed to determine whether there are sex differences in long-term functional decline after ischemic stroke. METHODS: We tracked functional status for 5 years among 3-month survivors of acute ischemic stroke and compared outcomes between women and men using a large-scale hospital-based stroke registry in Fukuoka, Japan. Functional status was assessed using the modified Rankin Scale (mRS). Functional dependency was defined as an mRS score of 3, 4, or 5. Logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals of outcomes after adjusting for possible confounders. RESULTS: A total of 8,446 patients (71.9 ± 12.5 years, 3,377 (40.0%) female patients) were enrolled in this study. Female sex was associated with a higher risk of functional dependency at 5 years poststroke even when adjusting for age, 3-month mRS score, and other confounding factors (multivariable-adjusted OR vs. men, 1.56 [95% confidence interval, 1.26-1.93]). This significant association of female sex with higher dependency at 5 years was also found among patients who were independent at 3 months poststroke. Subgroup analysis showed that increased risk of functional dependency in female patients was more marked in patients aged ≥75 years than in those aged <75 years (p for heterogeneity = 0.02). Conversely, female sex was associated with a lower risk of death. No sex difference was observed in stroke recurrence during 5 years poststroke. DISCUSSION/CONCLUSION: This longitudinal observational study suggests that female sex was independently associated with an increased risk of functional decline in the chronic phase of stroke, especially in older patients. There was no sex difference in 5-year stroke recurrence, and thus, other factors might be involved in more significant deterioration of functional status in female survivors of ischemic stroke. Further studies are needed to elucidate underlying causes of sex differences in long-term functional decline after stroke.

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  • Prospective study of adoptive activated αβT lymphocyte immunotherapy for refractory cancers: development and validation of a response scoring system. Reviewed International journal

    Atsushi Nonami, Ryu Matsuo, Kouta Funakoshi, Tomohiro Nakayama, Shigenori Goto, Tadafumi Iino, Shigeo Takaishi, Shinichi Mizuno, Koichi Akashi, Masatoshi Eto

    Cytotherapy   25 ( 1 )   76 - 81   2023.1   ISSN:1465-3249 eISSN:1477-2566

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    BACKGROUND AIMS: This prospective clinical study aimed to determine the efficacy and prognostic factors of adoptive activated αβT lymphocyte immunotherapy for various refractory cancers. The primary endpoint was overall survival (OS), and the secondary endpoint was radiological response. METHODS: The authors treated 96 patients. Activated αβT lymphocytes were infused every 2 weeks for a total of six times. Prognostic factors were identified by analyzing clinical and laboratory data obtained before therapy. RESULTS: Median survival time (MST) was 150 days (95% confidence interval, 105-191), and approximately 20% of patients achieved disease control (complete response + partial response + stable disease). According to the multivariate Cox proportional hazards model with Akaike information criterion-best subset selection, sex, concurrent therapy, neutrophil/lymphocyte ratio, albumin, lactate dehydrogenase, CD4:CD8 ratio and T helper (Th)1:Th2 ratio were strong prognostic factors. Using parameter estimates of the Cox analysis, the authors developed a response scoring system. The authors then determined the threshold of the response score between responders and non-responders. This threshold was able to significantly differentiate OS of responders from that of non-responders. MST of responders was longer than that of non-responders (317.5 days versus 74 days). The validity of this response scoring system was then confirmed by internal validation. CONCLUSIONS: Adoptive activated αβT lymphocyte immunotherapy has clinical efficacy in certain patients. The authors' scoring system is the first prognostic model reported for this therapy, and it is useful for selecting patients who might obtain a better prognosis through this modality.

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  • Associations Between Adherence to Evidence-Based, Stroke Quality Indicators and Outcomes of Acute Reperfusion Therapy. Reviewed International journal

    Nice Ren, Soshiro Ogata, Eri Kiyoshige, Kunihiro Nishimura, Ataru Nishimura, Ryu Matsuo, Takanari Kitazono, Takahiro Higashi, Kuniaki Ogasawara, Koji Iihara

    Stroke   53 ( 11 )   3359 - 3368   2022.11   ISSN:0039-2499 eISSN:1524-4628

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    BACKGROUND: Quality indicators (QIs) are an accepted tool for measuring a hospital's performance in routine care. We examined national trends in adherence to the QIs developed by the Close The Gap-Stroke program by combining data from the health insurance claims database and electronic medical records, and the association between adherence to these QIs and early outcomes in patients with acute ischemic stroke in Japan. METHODS: In the present study, patients with acute ischemic stroke who received acute reperfusion therapy in 351 Close The Gap-Stroke-participating hospitals were analyzed retrospectively. The primary outcomes were changes in trends for adherence to the defined QIs by difference-in-difference analysis and the effects of adherence to distinct QIs on in-hospital outcomes at the individual level. A mixed logistic regression model was adjusted for patient and hospital characteristics (eg, age, sex, number of beds) and hospital units as random effects. RESULTS: Between 2013 and 2017, 21 651 patients (median age, 77 years; 43.0% female) were assessed. Of the 25 defined measures, marked and sustainable improvement in the adherence rates was observed for door-to-needle time, door-to-puncture time, proper use of endovascular thrombectomy, and successful revascularization. The in-hospital mortality rate was 11.6%. Adherence to 14 QIs lowered the odds of in-hospital mortality (odds ratio [95% CI], door-to-needle <60 min, 0.80 [0.69-0.93], door-to-puncture <90 min, 0.80 [0.67-0.96], successful revascularization, 0.40 [0.34-0.48]), and adherence to 11 QIs increased the odds of functional independence (modified Rankin Scale score 0-2) at discharge. CONCLUSIONS: We demonstrated national marked and sustainable improvement in adherence to door-to-needle time, door-to-puncture time, and successful reperfusion from 2013 to 2017 in Japan in patients with acute ischemic stroke. Adhering to the key QIs substantially affected in-hospital outcomes, underlining the importance of monitoring the quality of care using evidence-based QIs and the nationwide Close The Gap-Stroke program.

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  • Efficacy of combined use of a stent retriever and aspiration catheter in mechanical thrombectomy for acute ischemic stroke. Reviewed International journal

    Tomohiro Okuda, Koichi Arimura, Ryu Matsuo, So Tokunaga, Kenta Hara, Shinya Yamaguchi, Hidenori Yoshida, Ryota Kurogi, Katsuharu Kameda, Osamu Ito, Tomoyuki Tsumoto, Koji Iihara, Taichiro Mizokami, Takeshi Uwatoko, Ataru Nishimura, Katsuma Iwaki, Masahiro Mizoguchi

    Journal of neurointerventional surgery   14 ( 9 )   892 - 897   2022.9   ISSN:1759-8478 eISSN:1759-8486

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    BACKGROUND: The efficacy of combined stent retriever (SR) and aspiration catheter (AC; combined technique: CBT) use for acute ischemic stroke (AIS) is unclear. We investigated the safety and efficacy of single-unit CBT (SCBT)-retrieving the thrombus as a single unit with SR and AC into the guide catheter-compared with single use of either SR or contact aspiration (CA). METHODS: We analysed 763 consecutive patients who underwent mechanical thrombectomy for AIS between January 2013 and January 2020, at six comprehensive stroke centers. Patients were divided into SCBT and single device (SR/CA) groups. The successful recanalization with first pass (SRFP) and other procedural outcomes were compared between groups. RESULTS: Overall, 240 SCBT and 301 SR/CA (SR 128, CA 173) patients were analyzed. SRFP (modified Thrombolysis In Cerebral Infarction (mTICI) ≥2c, 43.3% vs 27.9%, p<0.001; mTICI 3, 35.8% vs 25.5%, p=0.009) and final mTICI ≥2b recanalization (89.1% vs 82.0%, p=0.020) rates were significantly higher, puncture-to-reperfusion time was shorter (median (IQR) 43 (31.5-69) vs 55 (38-82.2) min, p<0.001), and the number of passes were fewer (mean±SD 1.72±0.92 vs 1.99±1.01, p<0.001) in the SCBT group. Procedural complications were similar between the groups. In subgroup analysis, SCBT was more effective in women, cardioembolic stroke patients, and internal carotid artery and M2 occlusions. CONCLUSIONS: SCBT increases the SRFP rate and shortens the puncture-to-reperfusion time without increasing procedural complications.

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  • Factors associated with health-related quality of life in long-stay inpatients with chronic schizophrenia

    Oyama, H; Oda, K; Matsuo, R

    PSYCHIATRY AND CLINICAL NEUROSCIENCES REPORTS   1 ( 3 )   e42   2022.9   ISSN:2769-2558

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    Aim: Few studies have investigated the health-related quality of life (HRQoL) in long-stay inpatients with chronic schizophrenia in Japan. This study aimed to clarify the factors associated with HRQoL among these patients. Methods: Out of 238 patients with chronic schizophrenia admitted to three hospitals, 101 inpatients provided informed consent to participate in the study. The patients' HRQoL was assessed using two instruments: the EuroQol 5 dimensions (EQ-5D) as a generic index and the Subjective Well-being Under Neuroleptic Treatment Scale, Japanese Version (SWNS-J) as a disease-specific index. We examined the factors associated with these HRQoL indices using multiple linear regression models. Results: The patients' mean age was 62.9 years, and 51.5% were female. The mean (standard deviation) EQ-5D score and SWNS-J total score were 0.776 (0.177) and 83.5 (16.5), respectively. Multiple linear regression analysis indicated that the EQ-5D score was significantly and negatively associated with the female sex, benzodiazepine use, and Drug-Induced Extrapyramidal Symptoms Scale scores. In contrast, the SWNS-J total score was significantly and negatively associated with first-generation antipsychotics use, Brief Psychiatric Rating Scale scores, Drug-Induced Extrapyramidal Symptoms Scale scores, and Global Assessment of Functioning scale scores. Conclusion: This study identified the factors associated with two HRQoL indices among long-stay inpatients with chronic schizophrenia in Japan. Although the analyses showed differences in the associated factors between the generic EQ-5D and the disease-specific SWNS-J, extrapyramidal symptoms as adverse effects of antipsychotic treatment were found to be associated with both indices.

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  • 長期入院中の慢性統合失調症患者における健康関連QoLの関連要因(Factors associated with health-related quality of life in long-stay inpatients with chronic schizophrenia)

    Oyama Hiroko, Oda Kouichi, Matsuo Ryu

    Psychiatry and Clinical Neurosciences Reports   1 ( 3 )   1 of 9 - 9 of 9   2022.9

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    長期入院中の慢性統合失調症(SZ)患者を対象とした質問紙調査を実施し、二つの健康関連QoL(HRQoL)指標の関連要因について検討した。3病院に入院中の慢性SZ患者101例(平均62.9歳、女性51.5%)を対象とした。評価項目は人口統計学的特徴および臨床的特徴、EuroQol 5 dimensions(EQ-5D)、Subjective Well-being Under Neuroleptic Treatment Scale Japanese Version(SWNS-J)、Brief Psychiatric Rating Scale(BPRS)、Drug Induced Extrapyramidal Symptoms Scale(DI EPSS)、機能の全体的評定尺度などとした。その結果、EQ-5Dスコアの平均値は0.776±0.177、SWNS-J総スコアは83.5±16.5であった。重回帰分析の結果、EQ-5Dスコアは、女性、ベンゾジアゼピンの使用、DI EPSSと有意かつ負の相関があることが示された。SWNS-Jの総得点は第1世代抗精神病薬の使用、BPRS、DI EPSS、機能の全体的評定尺度と有意かつ負の相関が認められた。以上のように、錐体外路症状はEQ-5DおよびSWNS-Jの両方におけるHRQoL低下と関連していた。

  • A Prognostic Scoring System Of Mechanical Thrombectomy For Elderly Patients

    Arimura, K; Miki, K; Nishimura, A; Matsuo, R; Koyanagi, Y; Okuda, T; Iwaki, K; Ido, K; Tokunaga, S; Yoshida, H; Yoshimoto, K

    STROKE   53   2022.2   ISSN:0039-2499 eISSN:1524-4628

  • Regional Disparity of Reperfusion Therapy for Acute Ischemic Stroke in Japan: A Retrospective Analysis of Nationwide Claims Data from 2010 to 2015. Reviewed International journal

    Megumi Maeda, Haruhisa Fukuda, Ryu Matsuo, Tetsuro Ago, Takanari Kitazono, Masahiro Kamouchi

    Journal of the American Heart Association   10 ( 20 )   e021853   2021.10

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  • Pre-Stroke Cholinesterase Inhibitor Treatment Is Beneficially Associated with Functional Outcome in Patients with Acute Ischemic Stroke and Pre-Stroke Dementia: The Fukuoka Stroke Registry. Reviewed International journal

    Yoshinobu Wakisaka, Ryu Matsuo, Kuniyuki Nakamura, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono

    Cerebrovascular diseases (Basel, Switzerland)   50 ( 4 )   390 - 396   2021.3

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  • Measuring Quality of Care for Ischemic Stroke Treated With Acute Reperfusion Therapy in Japan - The Close The Gap-Stroke. Reviewed

    Nice Ren, Ataru Nishimura, Ai Kurogi, Kunihiro Nishimura, Ryu Matsuo, Kuniaki Ogasawara, Yoichiro Hashimoto, Takahiro Higashi, Nobuyuki Sakai, Kazunori Toyoda, Yoshiaki Shiokawa, Teiji Tominaga, Shigeru Miyachi, Akiko Kada, Keisuke Abe, Kotaro Ono, Kazunori Matsumizu, Koichi Arimura, Takanari Kitazono, Susumu Miyamoto, Kazuo Minematsu, Koji Iihara

    Circulation journal : official journal of the Japanese Circulation Society   85 ( 2 )   201 - 209   2021.1

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  • Nationwide temporal trend analysis of reperfusion therapy utilization and mortality in acute ischemic stroke patients in Japan. Reviewed International journal

    Megumi Maeda, Haruhisa Fukuda, Ryu Matsuo, Fumi Kiyuna, Tetsuro Ago, Takanari Kitazono, Masahiro Kamouchi

    Medicine   100 ( 1 )   e24145   2021.1

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  • Effect of treatment modality and cerebral vasospasm agent on patient outcomes after aneurysmal subarachnoid hemorrhage in the elderly aged 75 years and older. Reviewed International journal

    15 ( 4 )   e0230953   2020.4

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    Objective We sought to examine whether the effect of treatment modality and drugs for cerebral vasospasm on clinical outcomes differs between elderly and non-elderly subarachnoid hemorrhage (SAH) patients in Japan. Methods We analyzed the J-ASPECT Study Diagnosis Procedure Combination database (n = 17,343) that underwent clipping or coiling between 2010 and 2014 in 579 hospitals. We stratified patients into two groups according to their age (elderly [≥75 years old], n = 3,885; non-elderly, n = 13,458). We analyzed the effect of treatment modality and anti-vasospasm agents (fasudil hydrochloride, ozagrel sodium, cilostazol, statin, eicosapentaenoic acid [EPA], and edaravone) on in-hospital poor outcomes (MRS 3-6 at discharge) and mortality using multivariable analysis. Results The elderly patients were more likely to be female, have impaired levels of consciousness and comorbidity, and less likely to be treated with clipping and anti-vasospasm agents, except for ozagrel sodium and statin. In-hospital mortality and poor outcomes were higher in the elderly (15.8&#37; vs. 8.5&#37;, 71.7&#37; vs. 36.5&#37;). Coiling was associated with higher mortality (odds ratio 1.43, 95&#37; confidence interval 1.2-1.7) despite a lower proportion of poor outcomes (0.84, 0.75-0.94) in the non-elderly, in contrast to no effect on clinical outcomes in the elderly. A comparable effect of anti-vasospasm agents on mortality was observed between nonelderly and elderly for fasudil hydrochloride (non-elderly: 0.20, 0.17-0.24), statin (0.63, 0.50-0.79), ozagrel sodium (0.72, 0.60-0.86), and cilostazol (0.63, 0.51-0.77). Poor outcomes were inversely associated with fasudil hydrochloride (0.59, 0.51-0.68), statin (0.84, 0.75-0.94), and EPA (0.83, 0.72-0.94) use in the non-elderly. No effect of these agents on poor outcomes was observed in the elderly. Conclusions In contrast to the non-elderly, no effect of treatment modality on clinical outcomes were observed in the elderly. A comparable effect of anti-vasospasm agents was observed on mortality, but not on functional outcomes, between the non-elderly and elderly.

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  • Development of Quality Indicators of Stroke Centers and Feasibility of Their Measurement Using a Nationwide Insurance Claims Database in Japan ― J-ASPECT Study ―. Reviewed

    83 ( 11 )   2292 - 2302   2019.10

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    Background: We aimed to develop quality indicators (QIs) related to primary and comprehensive stroke care and examine the feasibility of their measurement using the existing Diagnosis Procedure Combination (DPC) database. Methods and Results: We conducted a systematic review of domestic and international studies using the modified Delphi method. Feasibility of measuring the QI adherence rates was examined using a DPC-based nationwide stroke database (396,350 patients admitted during 2013–2015 to 558 hospitals participating in the J-ASPECT study). Associations between adherence rates of these QIs and hospital characteristics were analyzed using hierarchical logistic regression analysis. We developed 17 and 12 measures as QIs for primary and comprehensive stroke care, respectively. We found that measurement of the adherence rates of the developed QIs using the existing DPC database was feasible for the 6 QIs (primary stroke care: early and discharge antithrombotic drugs, mean 54.6&#37; and 58.7&#37;; discharge anticoagulation for atrial fibrillation, 64.4&#37;; discharge antihypertensive agents, 51.7&#37;; comprehensive stroke care: fasudil hydrochloride or ozagrel sodium for vasospasm prevention, 86.9&#37;; death complications of diagnostic neuroangiography, 0.4&#37;). We found wide inter-hospital variation in QI adherence rates based on hospital characteristics. Conclusions: We developed QIs for primary and comprehensive stroke care. The DPC database may allow efficient data collection at low cost and decreased burden to evaluate the developed QIs.

    DOI: 10.1253/circj.CJ-19-0089

  • Poor glycemic control and posterior circulation ischemic stroke. Reviewed International journal

    Junya Kuroda, Ryu Matsuo, Yuko Yamaguchi, Noriko Sato, Masahiro Kamouchi, Jun Hata, Yoshinobu Wakisaka, Tetsuro Ago, Takanari Kitazono

    Neurology. Clinical practice   9 ( 2 )   129 - 139   2019.4

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    DOI: 10.1212/CPJ.0000000000000608

  • Safety of antithrombotic therapy for patients with acute ischemic stroke harboring unruptured intracranial aneurysm Reviewed

    yuji shono, Hiroshi Sugimori, Ryu Matsuo, Yoshihisa Fukushima, Yoshinobu Wakisaka, Junya Kuroda, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono

    International Journal of Stroke   13 ( 7 )   734 - 742   2018.10

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    DOI: 10.1177/1747493018765263

  • Association of Embolic Sources With Cause-Specific Functional Outcomes Among Adults With Cryptogenic Stroke Reviewed

    Fumi Kiyuna, Noriko Sato, Ryu Matsuo, Masahiro Kamouchi, Jun Hata, Yoshinobu Wakisaka, Junya Kuroda, Tetsuro Ago, Takanari Kitazono

    JAMA network open   1 ( 5 )   e182953   2018.9

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    DOI: 10.1001/jamanetworkopen.2018.2953

  • Isolated and repeated stroke-like episodes in a middle-aged man with a mitochondrial ND3 T10158C mutation A case report Reviewed

    Satomi Mezuki, Kenji Fukuda, Tomonaga Matsushita, Yoshihisa Fukushima, Ryu Matsuo, Yu ichi Goto, Takehiro Yasukawa, Takeshi Uchiumi, Dongchon Kang, Takanari Kitazono, Tetsuro Ago

    BMC neurology   17 ( 1 )   2017.12

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    DOI: 10.1186/s12883-017-1001-4

  • Left atrial size and long-term risk of recurrent stroke after acute ischemic stroke in patients with nonvalvular atrial fibrillation Reviewed

    Toshiyasu Ogata, Ryu Matsuo, Fumi Kiyuna, Jun Hata, Tetsuro Ago, Yoshio Tsuboi, Takanari Kitazono, Masahiro Kamouchi, Takao Ishitsuka, Setsuro Ibayashi, Kenji Kusuda, Kenichiro Fujii, Tetsuhiko Nagao, Yasushi Okada, Masahiro Yasaka, Hiroaki Ooboshi, Katsumi Irie, Tsuyoshi Omae, Kazunori Toyoda, Hiroshi Nakane, Hiroshi Sugimori, Shuji Arakawa, Kenji Fukuda, Jiro Kitayama, Shigeru Fujimoto, Shoji Arihiro, Junya Kuroda, Yoshinobu Wakisaka, Yoshihisa Fukushima

    Journal of the American Heart Association   6 ( 8 )   2017.8

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    DOI: 10.1161/JAHA.117.006402

  • Adverse influence of pre-stroke dementia on short-term functional outcomes in patients with acute ischemic stroke The Fukuoka stroke registry Reviewed

    Yoshinobu Wakisaka, Ryu Matsuo, Jun Hata, Junya Kuroda, Takanari Kitazono, Masahiro Kamouchi, Tetsuro Ago

    Cerebrovascular Diseases   43 ( 1-2 )   82 - 89   2017.2

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    DOI: 10.1159/000453625

  • Influence of Statin Pretreatment on Initial Neurological Severity and Short-Term Functional Outcome in Acute Ischemic Stroke Patients The Fukuoka Stroke Registry Reviewed

    Hiromi Ishikawa, Yoshinobu Wakisaka, Ryu Matsuo, Noriko Makihara, Jun Hata, Junya Kuroda, Tetsuro Ago, Jiro Kitayama, Hiroshi Nakane, Masahiro Kamouchi, Takanari Kitazono

    Cerebrovascular Diseases   42 ( 5-6 )   395 - 403   2016.11

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    DOI: 10.1159/000447718

  • Causes of ischemic stroke in patients with non-valvular atrial fibrillation Reviewed

    Asako Nakamura, Junya Kuroda, Tetsuro Ago, Jun Hata, Ryu Matsuo, Shuji Arakawa, Takahiro Kuwashiro, Masahiro Yasaka, Yasushi Okada, Takanari Kitazono, Masahiro Kamouchi

    Cerebrovascular Diseases   42 ( 3-4 )   196 - 204   2016.7

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    DOI: 10.1159/000445723

  • Anti-Cyclic Citrullinated Peptide Antibody-Positive Meningoencephalitis in the Preclinical Period of Rheumatoid Arthritis Reviewed

    Tomoya Shibahara, Tomonaga Matsushita, Ryu Matsuo, Yoshihisa Fukushima, Kenji Fukuda, Hiroshi Sugimori, Masahiro Kamouchi, Takanari Kitazono, Tetsuro Ago

    Case Reports in Neurology   8 ( 2 )   156 - 160   2016.1

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    DOI: 10.1159/000447627

  • Intravascular large B cell lymphoma with cauda equina syndrome A case report and review of the literature authors Reviewed

    Shinichi Wada, Ryu Matsuo, Tomonaga Matsushita, Yoshihisa Fukushima, Tetsuro Ago, Takanari Kitazono

    Brain and Nerve   68 ( 1 )   97 - 101   2016.1

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  • Involvement of platelet-derived growth factor receptor β in fibrosis through extracellular matrix protein production after ischemic stroke Reviewed

    264   127 - 134   2015.2

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    Fibrosis is concomitant with repair processes following injuries in the central nervous system (CNS). Pericytes are considered as an origin of fibrosis-forming cells in the CNS. Here, we examined whether platelet-derived growth factor receptor β (PDGFRβ), a well-known indispensable molecule for migration, proliferation, and survival of pericytes, was involved in the production of extracellular matrix proteins, fibronectin and collagen type I, which is crucial for fibrosis after ischemic stroke. Immunohistochemistry demonstrated induction of PDGFRβ expression in vascular cells of peri-infarct areas at 3-7. days in a mouse stroke model. The PDGFRβ-expressing cells extended from peri-infarct areas toward the ischemic core after day 7 while expressing fibronectin and collagen type I in the infarct areas. In contrast, desmin and α-smooth muscle actin, markers of pericytes, were only expressed in vascular cells. In PDGFRβ heterozygous knockout mice, the expression of fibronectin and collagen type I was attenuated at both mRNA and protein levels with an enlargement of the infarct volume after ischemic stroke compared with that in wild-type littermates. In cultured brain pericytes, the expression of PDGF-B, PDGFRβ, fibronectin, and collagen type I, but not desmin, was significantly increased by serum depletion (SD). The SD-induced upregulation of fibronectin and collagen type I was suppressed by SU11652, an inhibitor of PDGFRβ, while PDGF-B further increased the SD-induced upregulation. In conclusion, the expression level of PDGFRβ may be a crucial determinant of fibrosis after ischemic stroke. Moreover, PDGFRβ signaling participates in the production of fibronectin and collagen type I after ischemic stroke.

    DOI: 10.1016/j.expneurol.2014.12.007

  • Sex differences in short-term outcomes after acute ischemic stroke The fukuoka stroke registry Reviewed

    Fumi Irie, Masahiro Kamouchi, Jun Hata, Ryu Matsuo, Yoshinobu Wakisaka, Junya Kuroda, Tetsuro Ago, Takanari Kitazono, Takao Ishitsuka, Shigeru Fujimoto, Setsuro Ibayashi, Kenji Kusuda, Shuji Arakawa, Kinya Tamaki, Seizo Sadoshima, Katsumi Irie, Kenichiro Fujii, Yasushi Okada, Masahiro Yasaka, Tetsuhiko Nagao, Hiroaki Ooboshi, Tsuyoshi Omae, Kazunori Toyoda, Hiroshi Nakane, Hiroshi Sugimori, Kenji Fukuda, Yoshihisa Fukushima

    Stroke   46 ( 2 )   471 - 476   2015.2

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    DOI: 10.1161/STROKEAHA.114.006739

  • Plasma S100A12 is associated with functional outcome after ischemic stroke Research for Biomarkers in Ischemic Stroke Reviewed

    Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Junya Kuroda, RyuMatsuo, Jun Hata, Seiji Gotoh, Tetsu Isomura, Hideto Awano, Kazuo Suzuki, Kenji Fukuda, Yasushi Okada, Yutaka Kiyohara, Hiroaki Ooboshi, Takanari Kitazono

    Journal of the Neurological Sciences   340 ( 1-2 )   75 - 79   2014.5

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    DOI: 10.1016/j.jns.2014.02.031

  • Gastrointestinal bleeding in acute ischemic stroke recent trends from the fukuoka stroke registry Reviewed

    Toshiyasu Ogata, Masahiro Kamouchi, Ryu Matsuo, Jun Hata, Junya Kuroda, Tetsuro Ago, Hiroshi Sugimori, Tooru Inoue, Takanari Kitazono

    Cerebrovascular diseases extra   4 ( 2 )   156 - 64   2014.5

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    DOI: 10.1159/000365245

  • A case of intravascular large B-cell lymphoma (IVLBCL) with central nervous system symptoms diagnosed by renal biopsy Reviewed

    Yuka Kanazawa, Noriko Hagiwara, Ryu Matsuo, Shuji Arakawa, Tetsuro Ago, Takanari Kitazono

    Clinical Neurology   54 ( 6 )   484 - 488   2014.1

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    DOI: 10.5692/clinicalneurol.54.484

  • Significance of plasma adiponectin for diagnosis, neurological severity and functional outcome in ischemic stroke - Research for Biomarkers in Ischemic Stroke (REBIOS) Reviewed

    Takahiro Kuwashiro, Tetsuro Ago, Masahiro Kamouchi, Ryu Matsuo, Jun Hata, Junya Kuroda, Kenji Fukuda, Hiroshi Sugimori, Masayo Fukuhara, Hideto Awano, Tetsu Isomura, Kazuo Suzuki, Masahiro Yasaka, Yasushi Okada, Yutaka Kiyohara, Takanari Kitazono

    Metabolism: Clinical and Experimental   63 ( 9 )   1093 - 1103   2014.1

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    DOI: 10.1016/j.metabol.2014.04.012

  • Nox4 is a major source of superoxide production in human brain pericytes Reviewed

    Junya Kuroda, Tetsuro Ago, ataru nishimura, Kuniyuki Nakamura, Ryu Matsuo, Yoshinobu Wakisaka, Masahiro Kamouchi, Takanari Kitazono

    Journal of Vascular Research   51 ( 6 )   429 - 438   2014.1

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    DOI: 10.1159/000369930

  • Magnetic resonance imaging in breath-hold divers with cerebral decompression sickness Reviewed

    Ryu Matsuo, Masahiro Kamouchi, Shuji Arakawa, Yoshihiko Furuta, Yuka Kanazawa, Takanari Kitazono

    Case Reports in Neurology   6 ( 1 )   23 - 27   2014.1

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    DOI: 10.1159/000357169

  • High blood pressure after acute ischemic stroke is associated with poor clinical outcomes Fukuoka stroke registry Reviewed

    Koji Ishitsuka, Masahiro Kamouchi, Jun Hata, Kenji Fukuda, Ryu Matsuo, Junya Kuroda, Tetsuro Ago, Takahiro Kuwashiro, Hiroshi Sugimori, Hiroshi Nakane, Takanari Kitazono

    Hypertension   63 ( 1 )   54 - 60   2014.1

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    DOI: 10.1161/HYPERTENSIONAHA.113.02189

  • Statins and the risks of stroke recurrence and death after ischemic stroke The Fukuoka Stroke Registry Reviewed

    Noriko Makihara, Masahiro Kamouchi, Jun Hata, Ryu Matsuo, Tetsuro Ago, Junya Kuroda, Takahiro Kuwashiro, Hiroshi Sugimori, Takanari Kitazono, Takao Ishitsuka, Shigeru Fujimoto, Setsuro Ibayashi, Kenji Kusuda, Shuji Arakawa, Katsumi Irie, Kenichiro Fujii, Yoshiyuki Wakugawa, Yasushi Okada, Masahiro Yasaka, Tetsuhiko Nagao, Hiroaki Ooboshi, Tsuyoshi Omae, Kazunori Toyoda, Hiroshi Nakane, Kenji Fukuda, Yoshihisa Fukushima, Kinya Tamaki, Seizo Sadoshima

    Atherosclerosis   231 ( 2 )   211 - 215   2013.12

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    DOI: 10.1016/j.atherosclerosis.2013.09.017

  • Intensity of anticoagulation and clinical outcomes in acute cardioembolic stroke the Fukuoka stroke Registry Reviewed

    Asako Nakamura, Tetsuro Ago, Masahiro Kamouchi, Jun Hata, Ryu Matsuo, Junya Kuroda, Takahiro Kuwashiro, Hiroshi Sugimori, Takanari Kitazono

    Stroke   44 ( 11 )   3239 - 3242   2013.11

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    DOI: 10.1161/STROKEAHA.113.002523

  • 両側中小脳脚および橋上部正中領域に血行力学性に脳梗塞を発症した両側椎骨動脈閉塞症の1 例 Reviewed

    古田芳彦, 金澤有華, 松尾龍, 荒川修治, 鴨打正浩, 北園孝成

    脳卒中   35 ( 5 )   337-342 (J-STAGE)   2013.9

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    Language:Japanese  

    DOI: 10.3995/jstroke.35.337

  • Progression of right internal carotid artery stenosis in ischemic stroke patient with autoimmune polyglandular syndrome A case report Reviewed

    Yuka Kanazawa, Ryu Matsuo, Yoshihisa Fukushima, Kenji Fukuda, Masahiro Kamouchi, Takanari Kitazono

    Clinical Neurology   53 ( 7 )   531 - 535   2013.8

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    DOI: 10.5692/clinicalneurol.53.531

  • Neurological decompression illness in a Japanese breath-hold diver A case report Reviewed

    Ryu Matsuo, Shuji Arakawa, Yoshihiko Furuta, Yuka Kanazawa, Masahiro Kamouchi, Takanari Kitazono

    Clinical Neurology   52 ( 10 )   757 - 761   2012.10

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    DOI: 10.5692/clinicalneurol.52.757

  • Role of NHE1 in calcium signaling and cell proliferation in human CNS pericytes Reviewed

    Kuniyuki Nakamura, Masahiro Kamouchi, Takanari Kitazono, Junya Kuroda, Ryu Matsuo, Noriko Hagiwara, Eiichi Ishikawa, Hiroaki Ooboshi, Setsuro Ibayashi, Mitsuo Iida

    American Journal of Physiology - Heart and Circulatory Physiology   294 ( 4 )   2008.4

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    DOI: 10.1152/ajpheart.01203.2007

  • Role of NHE1 in calcium oscillation and cell proliferation in human CNS pericytes Reviewed

    Kuniyuki Nakamura, Masahiro Kamouchi, Takanari Kitazono, Junya Kuroda, Ryu Matsuo, Noriko Hagiwara, Hiroaki Ooboshi, Setsuro Ibayashi, Mitsuo Iida

    Journal of Cerebral Blood Flow and Metabolism   27 ( SUPPL. 1 )   2007.11

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  • Venous infarction secondary to septic cavernous sinus thrombosis Reviewed

    Masahiro Kamouchi, Yoko Wakugawa, Yasushi Okada, Kazuhiro Kishikawa, Ryu Matsuo, Kazunori Toyoda, Kotaro Yasumori, Tooru Inoue, Setsuro Ibayashi, Mitsuo Iida

    Internal Medicine   45 ( 1 )   25 - 27   2006.2

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    DOI: 10.2169/internalmedicine.45.1430

  • The yeast eIF4E-associated protein Eap1p attenuates GCN4 translation upon TOR-inactivation Reviewed

    Ryu Matsuo, Hiroyuki Kubota, Tohru Obata, Keiji Kito, Kazuhisa Ota, Takanari Kitazono, Setsuro Ibayashi, Takuma Sasaki, Mitsuo Iida, Takashi Ito

    FEBS Letters   579 ( 11 )   2433 - 2438   2005.4

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    DOI: 10.1016/j.febslet.2005.03.043

  • Ultrasonographic detection of extracranial vertebral artery compression in bow hunter's brain ischemia caused by neck rotation Reviewed

    Masahiro Kamouchi, Kazuhiro Kishikawa, Ryu Matsuo, Kotaro Yasumori, Tooru Inoue, Yasushi Okada, Setsuro Ibayashi

    Cerebrovascular Diseases   16 ( 3 )   303 - 305   2003.8

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    DOI: 10.1159/000071134

  • Detection of intracranial aneurysm using transcranial color-coded duplex sonography with echo contrast agent Reviewed

    Shigeri Fujimoto, Tooru Inoue, Masahiro Kamouchi, Ryu Matsuo, Tsuyoshi Imamura, Takao Yonekura, Ken Uda, Tsutomu Hitotsumatsu, Kazunori Toyoda, Kotaro Yasumori, Yasushi Okada

    Japanese Journal of Neurosurgery   12 ( 3 )   179 - 184   2003.3

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    DOI: 10.7887/jcns.12.179

  • Cerebral infarction due to carotid occlusion caused by cervical vagal neurilemmoma Reviewed

    Ryu Matsuo, Masahiro Kamouchi, Tooru Inoue, Yasushi Okada, Setsuro Ibayashi

    Stroke   33 ( 5 )   1428 - 1431   2002.5

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    DOI: 10.1161/01.STR.0000015241.40071.99

  • Spontaneous regression of hepatocellular carcinoma - A case report Reviewed

    Ryu Matsuo, Hisanobu Ogata, H. Tsuji, Takanari Kitazono, M. Shimada, K. Taguchi, M. Fujishima

    Hepato-Gastroenterology   48 ( 42 )   1740 - 1742   2001.12

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  • Isolated dissection of the celiac artery A case report Reviewed

    Ryu Matsuo, Yuko Ohta, Yusuke Ohya, Takanari Kitazono, Hiroyuki Irie, Tatsuru Shikata, Isao Abe, Masatoshi Fujishima

    Angiology   51 ( 7 )   603 - 607   2000.1

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    DOI: 10.1177/000331970005100710

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Presentations

  • 地域疾患コホート「福岡脳卒中データベース研究」の新展開 Invited

    松尾龍, 脇坂義信, 吾郷哲朗, 鴨打正浩, 北園孝成

    66回日本脳循環代謝学会学術総会  2023.11 

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    Event date: 2023.11

    Language:Japanese  

    Country:Other  

  • 地域疾患コホート「福岡脳卒中データベース研究」の新展開 Invited

    松尾龍, 脇坂義信, 吾郷哲朗, 鴨打正浩, 北園孝成

    66回日本脳循環代謝学会学術総会  2023.11 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • 「脳卒中レジストリー・医療情報の現状と展望」福岡脳卒中データベース研究. Invited

    松尾 龍, 脇坂義信, 吾郷哲朗, 鴨打正浩, 北園孝成

    第48回日本脳卒中学会学術総会  2023.3 

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    Event date: 2023.3

    Language:Japanese  

    Country:Other  

  • 「脳卒中レジストリー・医療情報の現状と展望」福岡脳卒中データベース研究. Invited

    松尾 龍, 脇坂義信, 吾郷哲朗, 鴨打正浩, 北園孝成

    第48回日本脳卒中学会学術総会  2023.3 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

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  • 慢性腎臓病合併脳梗塞患者の臨床転帰 Invited

    松尾 龍, 鴨打正浩, 中村晋之, 脇坂義信, 吾郷哲朗, 北園孝成

    第46回日本脳卒中学会学術総会  2021.3 

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    Event date: 2021.3

    Language:Japanese  

    Country:Other  

  • Smoking status and functional outcomes after acute ischemic stroke International conference

    Matsuo R, Ago T, Kiyuna, F, Sato, N, Nakamura, K, Wakisaka Y, Kamouchi M, Kitazono T.

    5th European Stroke Organisation Conference 2019 (ESOC2019)  2019.5 

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    Event date: 2019.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Italy  

  • Short-term exposure to fine particulate matter (PM2.5) and risk of ischemic stroke in Japan International conference

    Matuso R; Michikawa T; Ago T; Ueda K; Yamazaki S; Nitta H; Takami A; Kamouchi M; Kitazono T

    11th World Stroke Congress 2018  2018.10 

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    Event date: 2018.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Canada  

  • Insulin resistance and clinical outcomes after acute ischemic stroke International conference

    Matsuo R, Ago T, Hata J, Wakisaka Y, Kuroda J, Kitazono T, Kamouchi M

    4th European Stroke Organisation Conference  2018.5 

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    Event date: 2018.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Sweden  

  • Short-term exposure to fine particulate matter increased hospital admissions for ischaemic stroke in Japan. International conference

    Michikawa T, Matsuo R, Ueda K, Ago T, Nitta H, Kitazono T, Kamouchi M

    Annual Scientific Conference of the International Society of Environmental Epidemiology 2017  2017.9 

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    Event date: 2017.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Australia  

  • Impact of onset-to-door time on clinical outcomes in patients with acute ischemic stroke: the Fukuoka Stroke Registry. International conference

    Matsuo R, Yamaguchi Y, Matsushita T, Fukuda K, Kiyuna F, Wakisaka Y, Kuroda J, Ago T, Kamouchi M, Kitazono T

    The 3rd European Stroke Organisation Conference 2017  2017.5 

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    Event date: 2017.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Other  

  • Association between neurological symptoms at stroke onset and use of ambulance– the Fukuoka Stroke Registry. International conference

    2016.7 

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    Event date: 2016.7

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Brisbane   Country:Australia  

  • Informed consent in a multicenter stroke registry: Fukuoka Stroke Registry. International conference

    Noichi Y, Matsuo R, Kamouchi M, Furukawa S, Kitamura T, Ito Y, Murao K, Arakawa S, Ago T, Kitazono T

    Asia Pacific Stroke Conference 2016  2016.7 

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    Event date: 2016.7

    Language:English   Presentation type:Oral presentation (general)  

    Country:Australia  

  • Association between high-sensitivity CRP at stroke onset and clinical outcomes in patients with small vessel occlusion. International conference

    Kiyuna F, Matsuo R, Wakisaka Y, Kuroda J, Ago T, Kamouchi M, Kitazono T

    2nd. European Stroke Organisation Conference 2016  2016.5 

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    Event date: 2016.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Spain  

  • Pioglitazone treatment and long-term post-stroke prognosis in diabetic patients with acute ischemic stroke: the Fukuoka Stroke Registry. International conference

    Matsuo R, Kamouchi M, Hata J, Wakisaka Y, Kuroda J, Ago T, Kitazono T

    Asia Pacific Stroke Conference 2015  2015.10 

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    Event date: 2015.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:Malaysia  

  • Association of high-sensitivity C-reactive protein at stroke onset with short-term clinical outcomes after ischemic stroke: the Fukuoka Stroke Registry International conference

    Matsuo R, Kamouchi M, Hata J, Wakisaka Y, Kuroda J, Ago T, Kitazono T

    1st . European Stroke Organisation Conference 2015  2015.4 

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    Event date: 2015.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Other  

  • 急性期脳卒中コホート Fukuoka Stroke Registry Invited

    松尾 龍

    第5回九州大学日本橋サテライトセミナー  2019.6 

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    Country:Other  

  • Fukuoka Stroke Registry研究からみえる脳梗塞診療の現状 Invited

    松尾 龍

    第12回 BHIC Fukuoka  2020.8 

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    Country:Other  

  • FSR研究の過去・現在・未来 Invited

    松尾 龍

    第36回「認知機能障害と脳循環研究会」  2020.10 

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    Country:Other  

  • Update on Japan Real World Evidence of DOAC efficacy and safety in secondary stroke prevention in NVAF patients Invited

    Ryu Matsuo

    United Christian Hospital Neurology Team Webinar  2021.12 

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    Country:Other  

  • 医療ビッグデータ時代の疫学統計 Invited

    松尾 龍

    2023.7 

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    Country:Other  

  • 医療ビッグデータ時代の疫学統計 Invited

    松尾 龍

    Next Generation Web Meeting  2023.7 

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  • 地域コホートからみえる脳卒中診療のエビデンス 〜福岡脳卒中データベース研究〜 Invited

    松尾 龍

    鳥栖三養基医師会学術講演会  2024.5 

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    Event date: 2024.5

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

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  • CLINICAL OUTCOMES AFTER ACUTE ISCHEMIC STROKE IN PATIENTS WITH COMORBID CANCER

    Matsuo R, Sato N, Kiyuna F, Irie F, Wakisaka Y, Kamouchi M, Kitazono T, Ago T

    10th European Stroke Organisation Conference 2024 (ESOC2024)  2024.5 

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    Event date: 2024.5

    Language:English  

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  • 脳卒中診療のエビデンス~福岡脳卒中データベース研究の知見 Invited

    松尾 龍

    脳卒中 WEB Seminer  2024.2 

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    Event date: 2024.2

    Language:Japanese  

    Country:Other  

  • 脳卒中診療のエビデンス〜福岡脳卒中データベース研究の知見 Invited

    松尾 龍

    脳卒中 WEB Seminer  2024.2 

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    Event date: 2024.2

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

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  • Impact of body temperature during the acute stage of stroke on clinical outcomes in patients with acute ischemic stroke International conference

    Mezuki S, Matsuo R, Osaki M, Shono Y, Sugimori H Arakawa S, Wakisaka Y, Ago T, Kamouchi M, Kitazono T

    5th European Stroke Organisation Conference 2019 (ESOC2019)  2019.5 

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    Event date: 2019.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Italy  

  • Secondary prevention and prognosis in ischemic stroke patients with atrial fibrillation and atherothrombotic disease:Fukuoka Stroke Registry

    2018.4 

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    Event date: 2018.4

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Athens   Country:Greece  

  • Cardiovascular outcomes in patients with minor ischaemic stroke or high-risk transient ischaemic attack in Japan: the Fukuoka Stroke Registry. International conference

    Matsuo R, Kamouchi M, Kiyuna F, Ago T, Kitazono T;

    2nd. European Stroke Organisation Conference 2016  2016.5 

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    Event date: 2016.5

    Language:English   Presentation type:Oral presentation (general)  

    Country:Spain  

  • Statin pretreatment is associated with initial stroke severity in non-cardioembolic ischemic stroke patients with dyslipidemia: The Fukuoka Stroke Registry. International conference

    Ishikawa H, Wakisaka Y, Makihara N, Ago T, Kuroda J, Matsuo R, Hata J, Nakane H, Kamouchi M, Kitazono T.

    1st . European Stroke Organisation Conference 2015  2015.4 

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    Event date: 2015.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Other  

  • Fukuoka Stroke Registry研究からみえる脳梗塞診療の現状 Invited

    松尾 龍

    第5回 蒼天翔る鶴の会 in FUKUOKA  2021.2 

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    Language:Japanese  

    Country:Other  

  • 臨床研究の進め方 Invited

    松尾 龍

    脳卒中分野NHO研究ネットワークグループ会議  2023.11 

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    Language:Japanese  

    Country:Other  

  • 福岡県後期高齢者医療費分析の結果報告

    松尾 龍, 西 巧, 馬場園 明

    高齢者の医療・介護・保健事業に関する研究会  2024.5 

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  • 慢性腎臓病の重症度分類と急性期虚血性脳卒中後の長期臨床転帰 Fukuoka Stroke Registry

    植木 香奈, 松尾 龍, 桑城 貴弘, 入江 芙美, 脇坂 義信, 吾郷 哲朗, 大星 博明, 鴨打 正浩, 北園 孝成

    脳循環代謝  2023.11  (一社)日本脳循環代謝学会

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  • 急性期脳内出血後の急性腎障害と脈圧の関連 Fukuoka Stroke Registry

    大屋 祐一郎, 松尾 龍, 植木 香奈, 脇坂 佳世, 清原 卓也, 中村 晋之, 脇坂 義信, 吾郷 哲朗, 鴨打 正浩, 北園 孝成

    脳循環代謝  2022.10  (一社)日本脳循環代謝学会

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  • 心房細動を有する腎機能障害患者の脳梗塞再発予防に対する抗凝固療法の検討 FSR研究

    佐原 範之, 緒方 利安, 山中 圭, 岡田 卓也, 北山 次郎, 松尾 龍, 脇坂 義信, 吾郷 哲朗, 鴨打 正浩, 北園 孝成

    臨床神経学  2023.9  (一社)日本神経学会

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  • 小児の重症外傷診療におけるNighttime Effect 日本外傷データバンク登録症例の解析

    大木 伸吾, 松尾 龍, 錦見 満暁, 大下 慎一郎, 志馬 伸朗

    日本集中治療医学会雑誌  2024.9  (一社)日本集中治療医学会

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    Language:Japanese  

  • 「データベース研究の新展開」 地域疾患コホート「福岡脳卒中データベース研究」の新展開

    松尾 龍, 脇坂 義信, 吾郷 哲朗, 鴨打 正浩, 北園 孝成

    脳循環代謝  2023.11  (一社)日本脳循環代謝学会

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  • RNF213 p.R4810K多型と頭頸部主幹動脈病変の関連 Fukuoka Stroke Registry

    高島 正光, 清原 卓也, 吉野 文隆, 日高 壮意, 中村 晋之, 松尾 龍, 脇坂 義信, 吾郷 哲朗, 鴨打 正浩, 北園 孝成

    脳循環代謝  2023.11  (一社)日本脳循環代謝学会

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  • ICUリハビリテーションにおける家族参加と患者アウトカムの関連 EMPICS研究

    安村 大拙, 松尾 龍, 渡辺 伸一, 劉 啓文, 神津 玲, 高橋 陽, 曷川 元, 大野 美香, 森田 恭正, 小谷 透

    日本集中治療医学会雑誌  2023.6  (一社)日本集中治療医学会

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    Language:Japanese  

  • 臨床研究の進め方 Invited

    松尾 龍

    脳卒中分野NHO研究ネットワークグループ会議  2023.11 

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    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

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  • 認知機能障害と脳梗塞再発の関連について Fukuoka Stroke Registry

    桑城 貴弘, 伊辻 花佳, 松尾 龍, 田川 直樹, 溝口 忠孝, 森 興太, 脇坂 義信, 吾郷 哲朗, 杉森 宏, 矢坂 正弘, 鴨打 正浩, 岡田 靖, 北園 孝成

    臨床神経学  2022.10  (一社)日本神経学会

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  • 高齢糖尿病患者での脳梗塞発症前血糖コントロール状況と脳梗塞後機能転帰の関連 Fukuoka Stroke Registry

    脇坂 義信, 松尾 龍, 清原 卓也, 中村 晋之, 吾郷 哲朗, 鴨打 正浩, 北園 孝成

    脳循環代謝  2023.11  (一社)日本脳循環代謝学会

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    Language:Japanese  

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MISC

  • 脳卒中データベース研究の展望 Reviewed

    松尾 龍

    福岡医学雑誌   2024.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 日本における脳卒中のレジストリ研究(Registry Studies of Stroke in Japan)

    Matsuo Ryu

    Journal of Atherosclerosis and Thrombosis   30 ( 9 )   1095 - 1103   2023.9   ISSN:1340-3478

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    Language:English   Publisher:(一社)日本動脈硬化学会  

  • 脳卒中データベース研究の展望

    松尾 龍

    福岡医学雑誌   114 ( 3 )   99 - 108   2023.9   ISSN:0016-254X

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    Language:Japanese   Publisher:福岡医学会  

    我が国における脳卒中データベース研究の代表的なものとして以下の4つを紹介し、海外の脳卒中データベース研究について概説した。1)福岡脳卒中データベース研究。2)日本脳卒中データベースバンク。3)J-ASPECT研究。4)NDB研究。

  • 【脳血管障害-脳卒中医療の今,そして未来】実地医家に必要な最新の知識 脳卒中疫学の最近の話題

    松尾 龍, 鴨打 正浩

    Medical Practice   39 ( 12 )   1797 - 1803   2022.12   ISSN:0910-1551

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    Language:Japanese   Publisher:(株)文光堂  

  • 【脳卒中と社会背景】気候・大気汚染と脳卒中

    松尾 龍, 吾郷 哲朗

    脳神経内科   97 ( 4 )   512 - 520   2022.10   ISSN:2434-3285

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    Language:Japanese   Publisher:(有)科学評論社  

  • 【脳卒中と社会背景】気候・大気汚染と脳卒中

    松尾龍, 吾郷哲朗

    脳神経内科 94:512-520, 2022   2022.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 【脳血管障害-脳卒中医療の今,そして未来】実地医家に必要な最新の知識 脳卒中疫学の最近の話題

    松尾龍, 鴨打正浩

    2022.9

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  • 【最新の診断と治療】脳梗塞各論 分類不能例 塞栓源不明脳塞栓症(ESUS)

    松尾龍

    日本臨床 80 増刊号2 最新臨床脳卒中学(下) 225-232, 2022   2022.7

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 【最新の診断と治療】疫学 Fukuoka Stroke Registry

    松尾龍, 北園孝成, 鴨打正浩

    日本臨床 80 増刊号1 最新臨床脳卒中学(上) 81-88, 2022   2022.6

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  • 【最新臨床脳卒中学(第2版)下-最新の診断と治療-】脳梗塞各論 分類不能例 塞栓源不明脳塞栓症(ESUS)

    松尾 龍

    日本臨床   80 ( 増刊2 最新臨床脳卒中学(下) )   225 - 232   2022.2   ISSN:0047-1852

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    Language:Japanese   Publisher:(株)日本臨床社  

  • 【最新臨床脳卒中学(第2版)上-最新の診断と治療-】疫学 Fukuoka Stroke Registry

    松尾 龍, 北園 孝成, 鴨打 正浩

    日本臨床   80 ( 増刊1 最新臨床脳卒中学(上) )   81 - 88   2022.1   ISSN:0047-1852

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    Language:Japanese   Publisher:(株)日本臨床社  

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Professional Memberships

  • 日本心血管脳卒中学会

  • 日本医療の質・安全学会

  • 日本プライマリケア連合学会

  • 日本公衆衛生学会

  • 日本臨床疫学会

  • 日本医療病院管理学会

  • 日本脳循環代謝学会

  • 日本脳卒中学会

  • 日本老年医学会

  • 日本内科学会

  • 日本脳循環代謝学会

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  • 日本脳卒中学会

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  • 日本老年医学会

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  • 日本心血管脳卒中学会

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  • 日本医療病院管理学会

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  • 日本内科学会

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Committee Memberships

  • 日本脳循環代謝学会   評議員  

       

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    Committee type:Academic society

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  • 日本医療病院管理学会   評議員  

       

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    Committee type:Academic society

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Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2023

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:16

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • Screening of academic papers

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:17

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:27

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:12

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • Screening of academic papers

    Role(s): Peer review

    2019

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:24

    Number of peer-reviewed articles in Japanese journals:2

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • Screening of academic papers

    Role(s): Peer review

    2018

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:16

    Number of peer-reviewed articles in Japanese journals:1

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • Screening of academic papers

    Role(s): Peer review

    2017

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:15

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • Screening of academic papers

    Role(s): Peer review

    2016

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:16

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • 座長(Chairmanship)

    第26回 認知機能障害と脳循環研究会  ( 福岡 ) 2015.4

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2015

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:19

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

  • Screening of academic papers

    Role(s): Peer review

    2014

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:7

    Number of peer-reviewed articles in Japanese journals:0

    Proceedings of International Conference Number of peer-reviewed papers:0

    Proceedings of domestic conference Number of peer-reviewed papers:0

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Research Projects

  • 医療と介護レセプト連結データを用いた脳卒中の疾病負荷に関する研究

    Grant number:24K02669  2024.4 - 2028.3

    科学研究費助成事業  基盤研究(B)

    松尾 龍, 入江 芙美, 松本 晃太郎

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    Grant type:Scientific research funding

    脳卒中はひとたび発症すると、その後遺症により容易に要介護状態となり、健康寿命が損なわれる。そのため、医療と介護が緊密に連携し、医療と介護の効率的かつ効果的な提供が求められる。しかしながら脳卒中患者の経時的な長期予後は明らかではなく、最適な医療と介護提供のためのエビデンスもみられない。我が国には匿名レセプト情報等および介護保険による匿名介護情報等が存在し、これらのデータを連結することで医療と介護の可視化が可能である。本研究では、医療と介護の連結データベースを用いて、脳卒中患者における医療と介護の実態を可視化し、長期予後を含む疾病負荷を明らかにすることをめざす。

    CiNii Research

  • 脳卒中後の日常生活動作の障害に関連する予後規定因子の解明

    Grant number:22K10386  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    入江 芙美, 松尾 龍, 北園 孝成

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    Grant type:Scientific research funding

    急性期脳卒中患者を対象とした大規模かつ網羅的な疾患コホート研究である「Fukuoka Stroke Registry:FSR」のデータベースを活用し、脳卒中発症後の日常生活動作(ADL)の障害に関連する予後規定因子を解明することを目指す。具体的には、脳卒中患者の発症5年後までのADLの状況について評価し、発症前の状況、入院時の臨床所見・検査結果、入院中の急性期治療の内容といった情報と併せて解析することで、脳卒中患者の長期機能予後に影響する因子を見出すことを目指す。これにより、脳卒中患者のADL改善にむけて対策を進める上でのターゲットが明らかになるものと期待される。

    CiNii Research

  • 脳卒中精密医療の基盤構築に関する研究

    Grant number:21K19648  2021.7 - 2025.3

    科学研究費助成事業  挑戦的研究(萌芽)

    鴨打 正浩, 吾郷 哲朗, 久保田 浩行, 中島 直樹, 松尾 龍, 北園 孝成

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    Grant type:Scientific research funding

    脳卒中患者の予後を精度高く予測するためには基礎疾患とその重症度、治療内容などに加え、大容量データを網羅的に統合し、機械学習、深層学習手法等を用いて数理的に推定する必要がある。縦断的疾患コホート研究を基軸に、情報科学と複雑系に対する最適解を見出すための次世代数理科学を融合する。個人に最適化した精密医療を実現すべく、網羅的かつ大容量のデータによるデータ駆動型予測を行う。

    CiNii Research

  • Data-driven high-performance medicine for stroke

    Grant number:23K21506  2021.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Grant type:Scientific research funding

    CiNii Research

  • 脳卒中患者における医療の質の妥当性の検証とデータベース構築に関する研究

    Grant number:21K10330  2021 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    松尾 龍, 北園 孝成, 鴨打 正浩

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    Authorship:Principal investigator  Grant type:Scientific research funding

    効果的、効率的な医療提供体制の確立には、医療の質の指標としてQIの妥当性を評価するとともに、持続的に医療の変化とともに変わるQIを評価しなければならない。本研究では、(1)本邦におけるQIについて、機能転帰を考慮したアウトカム評価で妥当性を検証する、(2)継続的にデータを収集し常に医療の質を評価できるデータベースを構築する、を行うことにより、効果的、効率的な脳卒中医療提供と脳卒中患者のアウトカムの改善の実現が期待できる。

    CiNii Research

  • Development of a Health Evaluation Platform for Local Residents and Verification of the Effectiveness of Preventive Healthcare and Long-term Care Services

    Grant number:19K21590  2019.6 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

    Fukuda Haruhisa

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    Grant type:Scientific research funding

    This study developed a platform capable of linking, at the individual resident level, various types of data owned by local governments, such as healthcare claims data, long-term care claims data, health examination data, and lists of implementers of preventive healthcare and long-term care services. As a result, we were able to construct a database of approximately 2 trillion records covering 7 years for 2.5 million people across 27 municipalities. Given that the data held by the municipalities lacked a common ID, this research entailed the development of technology and the accumulation of expertise for data consolidation. Additionally, we elucidated the effects of preventive healthcare and long-term care services on the healthy lifespan of the elderly and on healthcare and long-term care costs. We also developed a system that enables municipal staff to automatically search for high-risk individuals and carry out proactive preventive interventions within the local PC environment.

    CiNii Research

  • the cost-effectiveness of endovascular therapy for patients with acute ischemic stroke

    Grant number:18K09944  2018 - 2021

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

    CiNii Research

  • 脳卒中コホート研究を用いた、脳卒中発症後の障害を含む長期予後の解明に関する研究

    Grant number:15K08849  2015 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

▼display all

Class subject

  • 医療疫学

    2024.12 - 2025.2   Winter quarter

  • 環境保健学

    2024.12 - 2025.2   Winter quarter

  • 演習Ⅱ(松尾教授)

    2024.10 - 2025.3   Second semester

  • 医学概論

    2024.6 - 2024.8   Summer quarter

  • 医学統計学

    2024.6 - 2024.8   Summer quarter

  • 医療管理学

    2024.6 - 2024.8   Summer quarter

  • 内科学

    2024.6 - 2024.8   Summer quarter

  • 医学概論

    2024.6 - 2024.8   Summer quarter

  • 疫学・医学統計学Ⅱ

    2024.6 - 2024.8   Summer quarter

  • 疫学・医学統計学Ⅰ

    2024.6 - 2024.8   Summer quarter

  • 演習Ⅰ(松尾教授)

    2024.4 - 2024.9   First semester

  • 医療経済学

    2024.4 - 2024.9   First semester

  • 疫学

    2023.10 - 2024.3   Second semester

  • 環境保健学

    2023.10 - 2024.3   Second semester

  • 演習Ⅱ(松尾教授)

    2023.10 - 2024.3   Second semester

  • 臨床疫学

    2023.10 - 2024.3   Second semester

  • 医療管理学

    2023.4 - 2023.9   First semester

  • 医学統計学・疫学医学統計学(1)(2)

    2023.4 - 2023.9   First semester

  • 疫学・医学統計学Ⅱ

    2023.4 - 2023.9   First semester

  • 医療管理学

    2023.4 - 2023.9   First semester

  • 医学統計学

    2023.4 - 2023.9   First semester

  • 演習Ⅰ(松尾教授)

    2023.4 - 2023.9   First semester

  • 医療経済学

    2023.4 - 2023.9   First semester

  • 医学概論

    2023.4 - 2023.9   First semester

  • 疫学・医学統計学Ⅰ

    2023.4 - 2023.9   First semester

  • 疫学

    2022.10 - 2023.3   Second semester

  • 環境保健学

    2022.10 - 2023.3   Second semester

  • 演習Ⅱ(松尾准教授)

    2022.10 - 2023.3   Second semester

  • 臨床疫学

    2022.10 - 2023.3   Second semester

  • 医学概論

    2022.4 - 2022.9   First semester

  • 演習Ⅰ(松尾准教授)

    2022.4 - 2022.9   First semester

  • 医療経済学

    2022.4 - 2022.9   First semester

  • 環境保健学

    2021.10 - 2022.3   Second semester

  • 演習Ⅱ(松尾准教授)

    2021.10 - 2022.3   Second semester

  • 臨床疫学

    2021.10 - 2022.3   Second semester

  • 疫学

    2021.10 - 2021.12   Fall quarter

  • 環境保健学

    2021.4 - 2021.9   First semester

  • 医学概論

    2021.4 - 2021.9   First semester

  • 医学概論

    2021.4 - 2021.9   First semester

  • 演習Ⅰ(松尾准教授)

    2021.4 - 2021.9   First semester

  • 医療経済学

    2021.4 - 2021.9   First semester

  • 疫学

    2020.10 - 2021.3   Second semester

  • 演習Ⅱ(松尾准教授)

    2020.10 - 2021.3   Second semester

  • 医療経済学

    2020.4 - 2020.9   First semester

  • 臨床疫学

    2020.4 - 2020.9   First semester

  • 演習Ⅰ(松尾准教授)

    2020.4 - 2020.9   First semester

  • 疫学

    2019.10 - 2020.3   Second semester

  • 医療経済学

    2019.4 - 2019.9   First semester

  • 医療経済学

    2018.10 - 2019.3   Second semester

  • 疫学

    2018.4 - 2018.9   First semester

  • 医療経済学

    2017.10 - 2018.3   Second semester

  • 疫学

    2017.4 - 2017.9   First semester

  • 医療経済学

    2016.10 - 2017.3   Second semester

  • 疫学

    2016.4 - 2016.9   First semester

  • 医療経済学

    2015.10 - 2016.3   Second semester

  • 疫学

    2015.4 - 2015.9   First semester

▼display all

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Clinical Internal Medicine / Stroke Science

Clinician qualification

  • Preceptor

    The Japan Geriatrics Society

  • Preceptor

    The Japanese Society of Internal Medicine(JSIM)

  • Specialist

    The Japan Stroke Society

Year of medical license acquisition

  • 1998