Updated on 2025/05/12

Information

 

写真a

 
HATA JUN
 
Organization
Faculty of Medical Sciences Department of Basic Medicine Professor
Faculty of Medical Sciences Center for Cohort Studies(Concurrent)
Graduate School of Medical Sciences Department of Medicine(Concurrent)
Graduate School of Medical Sciences Department of Health Care Administration and Management(Concurrent)
School of Medicine Department of Medicine(Concurrent)
Title
Professor
Contact information
メールアドレス
Tel
0926426960
Profile
Lecture and education for master students at the Department of Health Care Administration and Management. Lecture and education of public health and epidemiological studies for undergraduate and PhD students. Epidemiological studies for chronic diseases (stroke, coronary heart disease, etc.) using the data from the Hisayama Study. Collaboration of epidemiological and clinical studies (in Kyushu University, domestic, and international stidies).
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Research Areas

  • Life Science / Hygiene and public health

  • Life Science / General internal medicine

  • Life Science / Medical management and medical sociology

Degree

  • MD, PhD ( 2006.3 Kyushu University )

Research History

  • Kyushu University 病院 研修医 

    1998.5 - 1999.5

  • 国立病院九州医療センター  研修医 

    1999.5 - 2000.5

  • 医療法人雪の聖母会聖マリア病院 脳血管内科 医師 

    2000.5 - 2001.4

  • 国立療養所福岡東病院 内科 レジデント 

    2001.5 - 2002.3

  • Kyushu University 医学研究院環境医学分野 Academic Researcher 

    2006.4 - 2010.1

  • シドニー大学 ジョージ国際保健研究所 客員研究員 

    2010.1 - 2012.12

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    Country:Australia

  • Kyushu University 医学研究院環境医学分野 Academic Researcher 

    2013.1 - 2013.7

  • Kyushu University 病院腎・高血圧・脳血管内科 Assistant Professor 

    2013.8 - 2014.4

  • Kyushu University 医学研究院附属総合コホートセンター Associate Professor 

    2014.5 - 2024.3

  • Kyushu University 医学研究院衛生・公衆衛生学分野 Associate Professor 

    2016.8 - 2024.3

  • Kyushu University 医学研究院医療経営・管理学講座 Professor 

    2024.4 - Present

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    Country:Japan

  • Kyushu University 医学研究院附属総合コホートセンター Professor 

    2024.4 - Present

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Education

  • Kyushu University   医学部   医学科

    1992.4 - 1998.3

  • Kyushu University   医学系学府  

    2002.4 - 2006.3

Research Interests・Research Keywords

  • Research theme: 高血圧

    Keyword: 高血圧

    Research period: 2025

  • Research theme: 頭部MRI

    Keyword: 頭部MRI

    Research period: 2025

  • Research theme: 認知症

    Keyword: 認知症

    Research period: 2025

  • Research theme: 脳血管障害

    Keyword: 脳血管障害

    Research period: 2025

  • Research theme: 脂質異常症

    Keyword: 脂質異常症

    Research period: 2025

  • Research theme: 肥満

    Keyword: 肥満

    Research period: 2025

  • Research theme: 糖尿病

    Keyword: 糖尿病

    Research period: 2025

  • Research theme: 疫学研究

    Keyword: 疫学研究

    Research period: 2025

  • Research theme: 久山町研究

    Keyword: 久山町研究

    Research period: 2025

  • Research theme: 一塩基多型

    Keyword: 一塩基多型

    Research period: 2025

  • Research theme: コホート研究

    Keyword: コホート研究

    Research period: 2025

  • Research theme: Epidemiological study for NCDs and senile diseases using the large-scale health data from Fukuoka City residents

    Keyword: Epidemiological study

    Research period: 2024.1

  • Research theme: Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD)

    Keyword: Dementia, depression, cohort study

    Research period: 2015.9

  • Research theme: The Hisayama Study

    Keyword: epidemiology, lifestyle diseases, stroke, coronary heart disease, risk factors

    Research period: 2002.4

Awards

  • Best Reviewers of Hypertension Research 2023

    2024.2   日本高血圧学会  

  • Best Reviewers of Hypertension Research 2022

    2023.1   日本高血圧学会  

  • Circulation Journal Award 2021

    2022.3   日本循環器学会   Risk prediction model for incident atrial fibrillation in a general Japanese population: the Hisayama Study

  • 第25回日本未病システム学会学術総会優秀演題賞

    2018.10   日本未病システム学会   βアラニン血中濃度と認知症発症の関連:久山町研究

  • 第9回Hypertension Research Award

    2018.9   日本高血圧学会   ‘White-coat and masked hypertension are associated with albuminuria in a general population: the Hisayama Study

Papers

  • Risk prediction model for incident atrial fibrillation in a general Japanese population: the Hisayama Study Reviewed

    Hata J, Nagata T, Sakata S, Oishi E, Furuta Y, Hirakawa Y, Honda T, Yoshida D, Kitazono T, Ninomiya T.

    Circ J   2021.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    Background: The risk prediction of incident atrial fibrillation (AF) is useful to prevent AF and its complications. The aim of this study is to develop a new risk prediction model for incident AF using the prospective longitudinal data from a general Japanese population.
    Methods and Results: A total of 2,442 community-dwelling AF-free residents aged ≥40 years were followed up from 1988 to 2012 (46,422 person-years). The development of AF was confirmed by a standard 12-lead electrocardiogram at repeated health examinations and by medical records at clinics or hospitals. The risk prediction model for incident AF was developed using a Cox proportional hazards model. During the follow up, 230 AF events were confirmed. Age, sex, systolic blood pressure, waist circumference, estimated glomerular filtration rate, abnormal cardiac murmur, high R-wave amplitude, and arrhythmia other than AF were selected for inclusion in the model. This model showed good discrimination (Harrell's c statistics: 0.785) and calibration (Greenwood-Nam-D'Agostino test: P=0.87) for AF risk at 10 years.
    Conclusions: The new risk prediction model showed good performance on the individual risk assessment of the future onset of AF in a general Japanese population. As this model included commonly used clinical parameters, it may be useful for determining the requirements for the careful evaluation of AF, such as frequent electrocardiogram examinations in clinical settings, and subsequent reductions in the risk of AF-related complications.

    DOI: 10.1253/circj.CJ-20-0794

  • Association between serum β-alanine and risk of dementia Reviewed International journal

    Hata J, Ohara T, Katakura Y, Shimizu K, Yamashita S, Yoshida D, Honda T, Hirakawa Y, Shibata M, Sakata S, Kitazono T, Kuhara S, Ninomiya T.

    Am J Epidemiol   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/aje/kwz116

  • White-coat and masked hypertension are associated with albuminuria in a general population: the Hisayama Study Reviewed

    Hata J, Fukuhara M, Sakata S, Arima H, Hirakawa Y, Yonemoto K, Mukai N, Kitazono T, Kiyohara Y, Ninomiya T.

    Hypertens Res   2017.11

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    DOI: 10.1038/hr.2017.74

  • Risk prediction models for mortality in patients with cardiovascular disease: the BioBank Japan project Reviewed

    Hata J, Nagai A, Hirata M, Kamatani Y, Tamakoshi A, Yamagata Z, Muto K, Matsuda K, Kubo M, Nakamura Y; Biobank Japan Cooperative Hospital Group, Kiyohara Y, Ninomiya T.

    J Epidemiol   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.je.2016.10.007

  • Serum angiopoietin-like protein 2 is a novel risk factor for cardiovascular disease in the community: the Hisayama Study Reviewed International journal

    Hata J, Mukai N, Nagata M, Ohara T, Yoshida D, Kishimoto H, Shibata M, Hirakawa Y, Endo M, Ago T, Kitazono T, Oike Y, Kiyohara Y, Ninomiya T.

    Arterioscler Thromb Vasc Biol   2016.8

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    DOI: 10.1161/ATVBAHA.116.307291

  • Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009) Reviewed International journal

    Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y.

    Circulation   2013.9

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    DOI: 10.1161/CIRCULATIONAHA.113.002424

  • Effects of visit-to-visit variability in systolic blood pressure on macrovascular and microvascular complications in patients with type 2 diabetes mellitus: the ADVANCE trial Reviewed International journal

    Hata J, Arima H, Rothwell PM, Woodward M, Zoungas S, Anderson C, Patel A, Neal B, Glasziou P, Hamet P, Mancia G, Poulter N, Williams B, Macmahon S, Chalmers J; ADVANCE Collaborative Group.

    Circulation   2013.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/CIRCULATIONAHA.113.002717

  • Effects of the endpoint adjudication process on the results of a randomised controlled trial: the ADVANCE trial Reviewed International journal

    Hata J, Arima H, Zoungas S, Fulcher G, Pollock C, Adams M, Watson J, Joshi R, Kengne AP, Ninomiya T, Anderson C, Woodward M, Patel A, Mancia G, Poulter N, MacMahon S, Chalmers J, Neal B; ADVANCE Collaborative Group.

    PLoS One   2013.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0055807

  • Combined effects of smoking and hypercholesterolemia on the risk of stroke and coronary heart disease in Japanese: the Hisayama Study Reviewed International journal

    Hata J, Doi Y, Ninomiya T, Fukuhara M, Ikeda F, Mukai N, Hirakawa Y, Kitazono T, Kiyohara Y.

    Cerebrovasc Dis   2011.1

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    DOI: 10.1159/000324392

  • The effect of metabolic syndrome defined by various criteria on the development of ischemic stroke subtypes in a general Japanese population Reviewed International journal

    Hata J, Doi Y, Ninomiya T, Tanizaki Y, Yonemoto K, Fukuhara M, Kubo M, Kitazono T, Iida M, Kiyohara Y.

    Atherosclerosis   2010.5

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    DOI: 10.1016/j.atherosclerosis.2009.10.044

  • Secular trends in the incidence of and risk factors for ischemic stroke and its subtypes in Japanese population Reviewed International journal

    Kubo M, Hata J, Doi Y, Tanizaki Y, Iida M, Kiyohara Y.

    Circulation   2008.12

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    DOI: 10.1161/CIRCULATIONAHA.107.743211

  • Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction Reviewed International journal

    Hata J, Matsuda K, Ninomiya T, Yonemoto K, Matsushita T, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Iida M, Kiyohara Y, Nakamura Y, Kubo M.

    Hum Mol Genet   2007.3

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    DOI: 10.1093/hmg/ddm005

  • Ten year recurrence after first ever stroke in a Japanese community: the Hisayama Study Reviewed International journal

    Hata J, Tanizaki Y, Kiyohara Y, Kato I, Kubo M, Tanaka K, Okubo K, Nakamura H, Oishi Y, Ibayashi S, Iida M.

    J Neurol Neurosurg Psychiatry   2005.3

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    DOI: 10.1136/jnnp.2004.038166

  • Impaired family functioning is associated with depressive symptoms in a community-dwelling Japanese population: The Hisayama Study

    Nagasawa F., Shibata M., Hirabayashi N., Chen S., Yoshida D., Hata J., Sudo N., Ninomiya T.

    Journal of Affective Disorders Reports   20   2025.4

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    Publisher:Journal of Affective Disorders Reports  

    Background: Several clinical studies have reported an association between impaired family functioning and depressive symptoms. However, epidemiological evidence is limited. The aim of this study was to investigate the association between family functioning and the presence of depressive symptoms in a community-dwelling Japanese population. Methods: A total of 2,595 participants aged ≥40 years were included. Impaired family functioning levels were assessed by using a short version of the general functioning subscale of the McMaster Family Assessment Device (GF6+). Impaired family functioning levels were categorized as healthy (GF6+ score: ≤1.80), borderline (1.81–2.00), or unhealthy (>2.00). The presence of depressive symptoms was defined as a score of ≥10 on Patient Health Questionaire-9. A logistic regression model was used to compute the odds ratios (ORs) for the presence of depressive symptom. Results: The age-adjusted prevalence of depressive symptoms was 5.4 % for men and 7.0 % for women. In both sexes, the age-adjusted prevalence of depressive symptoms increased significantly with increasing impaired family functioning levels (both P for trend <0.001). The ORs (95 % confidence intervals) for having depressive symptoms among the borderline and unhealthy groups were 3.32 (1.51–7.29) and 4.09 (1.76–9.54) for men, and 1.04 (0.56–1.95) and 3.02 (1.76–5.18) for women, respectively, compared with the healthy group after adjustment for potential confounders. Limitation: Reverse causality is possible due to the cross-sectional design. Conclusions: Impaired family functioning was associated with an increased risk of the presence of depressive symptoms. It may be important considering the family functioning in managing depressive symptoms.

    DOI: 10.1016/j.jadr.2025.100900

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  • Association of impaired olfactory identification with prevalent mild cognitive impairment and regional brain atrophy: the Hisayama Study

    Minohara, T; Ohara, T; Nakazawa, T; Hirabayashi, N; Furuta, Y; Shibata, M; Hata, J; Kitazono, T; Nakao, T; Ninomiya, T

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   2025.3   ISSN:1323-1316 eISSN:1440-1819

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    Aim: To investigate the association of olfactory identification ability with both the prevalence of mild cognitive impairment (MCI) and regional brain atrophy in a community-dwelling older population. Methods: A total of 1293 participants without dementia aged 65 years or older underwent a Japanese version of the 4-Item Pocket Smell Test, an assessment of cognitive function, and brain magnetic resonance imaging scanning in 2017–2018. Regional gray matter volumes (GMVs) and white matter lesions volume (WMLV) were estimated using FreeSurfer software. The association of impaired olfactory identification with the presence of MCI and regional GMVs or WMLV was estimated by logistic regression analysis and ANCOVA, respectively. We also assessed the association between impaired olfactory identification and GMVs without regions of interest, using a voxel-based morphometry (VBM) analysis. Results: Participants with impaired olfactory identification had a significantly higher likelihood of MCI than those without (odds ratio, 1.99 [95% confidence interval, 1.36–2.91]). In the FreeSurfer analysis, participants with impaired olfactory identification had significantly lower GMVs in the entorhinal cortex, inferior temporal gyrus, amygdala, thalamus, hippocampus, and cingulate gyrus, and higher WMLV than those without. The VBM analysis also showed that impaired olfactory identification was significantly associated with lower volume of the left entorhinal cortex, left amygdala, left hippocampus, bilateral thalami, and bilateral subcallosal areas. Conclusion: Our findings suggest that cognitive function and brain changes may need to be evaluated in older individuals with impaired olfactory identification, which may reflect the extent of neurodegeneration, WMLV, and subsequent cognitive impairment.

    DOI: 10.1111/pcn.13813

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  • Clinical Outcomes following Acute Ischaemic Stroke in Patients with Comorbid Cancer. International journal

    Noriko Sato, Fumi Kiyuna, Kayo Wakisaka, Yuichiro Ohya, Kana Ueki, Sohei Yoshimura, Kuniyuki Nakamura, Jun Hata, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono, Ryu Matsuo

    Cerebrovascular diseases (Basel, Switzerland)   1 - 9   2025.3   ISSN:1015-9770 eISSN:1421-9786

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    INTRODUCTION: The prevalence of comorbid cancer is higher in patients with ischaemic stroke than in the general population, and recent studies have attempted to clarify the relationship between the two. We observed that the evidence for the impact of comorbid cancer on post-stroke clinical outcomes was not established and aimed to investigate it among patients with new-onset acute ischaemic stroke. METHODS: We evaluated 13,345 patients with acute ischaemic stroke who were functionally independent before onset (modified Rankin Scale [mRS] score of 0-2) and admitted to one of the seven stroke centres in Fukuoka, Japan, between June 2007 and September 2019. A total of 13,047 patients were included in the analyses after excluding those with missing potential confounders (n = 13) or loss to follow-up (n = 298). Comorbid cancer was diagnosed based on previous history or newly identified cancer during hospitalisation for the index stroke. Multivariable-adjusted Poisson regression analyses were conducted to assess the association of comorbid cancer with post-stroke outcomes: clinically assessed poor functional outcomes (mRS score, 3-6), functional dependency (mRS score, 3-5), and mortality (mRS score, 6) at 3 months after stroke onset. RESULTS: Of 13,047 patients (aged 71.1 ± 12.3 years, 62.8% men) with acute ischaemic stroke, 2,027 (15.6%) had comorbid cancer. Among those with no cancer, 24.0% recorded poor functional outcomes; with non-active cancer, 30.7%; and with active cancer, 46.1%. The risk ratios (95% confidence interval) for poor functional outcome at 3 months increased with active cancer (1.50 [1.37-1.65] vs. no cancer) and recently diagnosed cancer (7 months-4 years: 1.43 [1.28-1.59], ≤6 months: 1.53 [1.36-1.72]) after adjusting for potential confounders. These associations were observed for both 3-month functional dependency and mortality. No significant heterogeneity was observed in these associations across sex, nutritional status, inflammatory status, or coagulation status, except for age and stroke severity. The strongest association with 3-month poor functional outcome was observed for pancreatic cancer, followed by gallbladder and biliary tract, liver, and colon cancers. CONCLUSIONS: Comorbid cancer is likely to be independently associated with unfavourable outcomes in patients with acute ischaemic stroke.

    DOI: 10.1159/000544700

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  • Functional Outcome Prediction in Japanese Patients with Nonsurgical Intracerebral Hemorrhage: The FSR ICH Score. International journal

    Takuya Kiyohara, Ryu Matsuo, Fumi Irie, Kuniyuki Nakamura, Jun Hata, Yoshinobu Wakisaka, Takanari Kitazono, Masahiro Kamouchi, Tetsuro Ago

    Cerebrovascular diseases (Basel, Switzerland)   1 - 8   2025.1   ISSN:1015-9770 eISSN:1421-9786

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    INTRODUCTION: There has been limited research on predicting the functional prognosis of patients with nonsurgical intracerebral hemorrhage (ICH) from the acute stage. The aim of this study was to develop a risk prediction model for the natural course in patients with nonsurgical ICH and to evaluate its performance using a multicenter hospital-based prospective study of stroke patients in Japan. METHODS: We consecutively registered a total of 1,017 patients with acute ICH (mean age, 68 years) who underwent conservative treatment and followed them up for 3 months. The study outcome was a poor functional outcome (modified Rankin Scale score, 4-6) at 3 months after ICH onset. To develop the risk prediction model for natural course in patients with nonsurgical ICH, we included the following clinical common factors assessed on admission in daily clinical practice for ICH: age, sex, medical history (hypertension, diabetes mellitus, dyslipidemia, pre-stroke dementia, previous stroke, coronary artery disease, smoking status, alcohol drinking status, oral anticoagulation, and antiplatelet medication), admission status (time from onset to admission, systolic blood pressure, diastolic blood pressure, pulse pressure, plasma glucose levels, severity of the stroke), and neuroradiologic data (ICH location, intraventricular hemorrhage, and hematoma volume). The risk prediction model for poor functional outcome was developed using logistic regression analysis. In addition, the risk prediction model was translated into a point-based simple risk score (FSR ICH score) using the approach in the Framingham Heart Study. RESULTS: At 3 months after the ICH onset, 323 (31.8%) patients developed a poor functional outcome. Age, diabetes mellitus, pre-stroke dementia, NIHSS score on admission, intraventricular hemorrhage, and hematoma volume were included in the risk prediction model. This model demonstrated excellent discrimination (C statistic = 0.884 [95% confidence interval, 0.863-0.905]; optimism-corrected C statistic based on 200 bootstrap samples = 0.877) and calibration (Hosmer-Lemeshow goodness-of-fit test: p = 0.72). The FSR ICH score, a point-based simple risk score, also showed excellent discrimination, with a C statistic of 0.882 (95% CI: 0.861-0.903). CONCLUSIONS: We developed a new risk prediction model for 3-month poor functional outcome in patients with nonsurgical ICH using a multicenter hospital-based prospective study in Japan. The current risk prediction model has the potential to be a useful tool for estimating the natural course in patients with nonsurgical ICH, aiding in making treatment decisions, including surgical options, early formulation of rehabilitation plans, and efficient utilization of medical resources.

    DOI: 10.1159/000543362

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  • Green tea consumption and cerebral white matter lesions in community-dwelling older adults without dementia. International journal

    Shutaro Shibata, Moeko Noguchi-Shinohara, Ayano Shima, Taro Ozaki, Yuta Usui, Yasuyuki Taki, Kazuhiro Uchida, Takanori Honda, Jun Hata, Tomoyuki Ohara, Tatsuya Mikami, Tetsuya Maeda, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya, Kenjiro Ono

    NPJ science of food   9 ( 1 )   2 - 2   2025.1   eISSN:2396-8370

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    This study investigated the association between green tea or coffee consumption with cerebral white matter lesions and hippocampal and total brain volumes among 8766 community-dwelling participants recruited from the Japan Prospective Studies Collaboration for Aging and Dementia between 2016 and 2018. A Food Frequency Questionnaire was used to assess green tea and coffee consumption, whereas brain magnetic resonance imaging was performed to assess cerebral white matter lesions, hippocampal volume, and total brain volume. Multivariable-adjusted analysis revealed significant correlations between fewer cerebral white matter lesions and higher green tea consumption, whereas no significant differences were found between green tea consumption and hippocampal or total brain volume. Regarding coffee consumption, no significant differences were observed in cerebral white matter lesions or hippocampal or total brain volumes. Hence, higher green tea consumption was associated with fewer cerebral white matter lesions, suggesting that it may be useful in preventing dementia.

    DOI: 10.1038/s41538-024-00364-w

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  • Transition of Metabolic Health Status and the Risk of Cardiovascular Diseases in a Japanese Population: the Hisayama Study

    Higashioka Mayu, Sakata Satoko, Oishi Emi, Honda Takanori, Shibata Mao, Hata Jun, Kitazono Takanari, Osawa Haruhiko, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   advpub ( 0 )   2025   ISSN:13403478 eISSN:18803873

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    Language:English   Publisher:Japan Atherosclerosis Society  

    <p> <b>Aims:</b> To investigate the association between metabolic health status, defined by the combination of metabolic syndrome (MetS) and obesity, and cardiovascular disease (CVD) in a Japanese community.</p><p><b>Methods:</b> A total of 2,842 participants without prior CVD, aged 40 years or older, were followed up from 2007 until 2017. Participants were classified into 4 metabolic health statuses based on the presence of obesity (body mass index ≥ 25 kg/m<sup>2</sup>) and MetS: metabolically healthy normal weight (MHN) (obesity [-] and MetS [-]), metabolically unhealthy normal weight (MUN) (obesity [-] and MetS [+]), metabolically healthy obesity (MHO) (obesity [+] and MetS [-]), and metabolically unhealthy obesity (MUO) (obesity [+] and MetS [+]). The risk estimates were computed by using a Cox hazard regression analysis.</p><p> <b>Results:</b> During the follow-up period, 190 participants developed CVD. The MUO group had a 1.94-times greater risk of developing CVD than the MHN group after adjusting for confounders, but no excess risk was observed in the MHO group. Moreover, in 1,595 participants who had undergone a health checkup in 2002, 5 years before baseline, the risk of developing CVD was 2.18-times greater in the group that transitioned from MHO to MUO and 1.75-times higher in the stable MUO group than in the stable MHN group, but was not higher in the stable MHO group.</p><p><b>Conclusions:</b> The present findings suggest that cardiovascular risk increases when metabolic abnormalities are present simultaneously with obesity. In individuals with obesity, it may be important to maintain metabolic health and/or lose weight to prevent CVD.</p>

    DOI: 10.5551/jat.65275

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  • Influence of chronic pain on regional brain volume reduction in a general older Japanese population: a longitudinal imaging analysis from the Hisayama Study

    Nakamura, Y; Shibata, M; Hirabayashi, N; Nakazawa, T; Furuta, Y; Hata, J; Hosoi, M; Sudo, N; Yamaura, K; Ninomiya, T

    BRAIN COMMUNICATIONS   7 ( 2 )   fcaf149   2025   eISSN:2632-1297

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  • Association between dynapenic obesity and risk of cardiovascular disease: The Hisayama study. International journal

    Yu Setoyama, Takanori Honda, Takahiro Tajimi, Satoko Sakata, Emi Oishi, Yoshihiko Furuta, Mao Shibata, Jun Hata, Takanari Kitazono, Yasuharu Nakashima, Toshiharu Ninomiya

    Journal of cachexia, sarcopenia and muscle   15 ( 6 )   2338 - 2348   2024.12   ISSN:2190-5991 eISSN:2190-6009

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Cachexia, Sarcopenia and Muscle  

    BACKGROUND: Dynapenic obesity is a condition characterized by high adiposity levels combined with muscle dysfunction. Although high adiposity and muscle loss/dysfunction are thought to synergistically increase the risk of cardiovascular disease (CVD), few studies have addressed the association between dynapenic and sarcopenic obesity and CVD. We aimed to investigate the association of dynapenic obesity with incident CVD events using the data from a population-based prospective longitudinal study in Japan. METHODS: A total of 2490 community-dwelling Japanese aged 40-79 years (42.5% males, mean age 57.7 ± 10.6 years) without a history of CVD were followed up for a median of 24 years. Handgrip strength was classified as low, medium, or high by age- and sex-specific tertiles. Body mass index (BMI) levels were categorized as lean (<18.5 kg/m2), normal (18.5-24.9 kg/m2), or obese (≥25.0 kg/m2). Dynapenic obesity was defined as having both low handgrip strength and obesity. The outcomes were defined as the first-ever development of CVD (defined as stroke or coronary heart disease). The hazard ratios (HRs) and their 95% confidence intervals (CIs) for the development of CVD were estimated using a Cox proportional hazards model, in which participants with high handgrip strength and normal BMI were used as a reference group. Mediation analyses used serum high-sensitivity C-reactive protein (hs-CRP) and homeostatic model assessment for insulin resistance (HOMA-IR) as mediators. RESULTS: During the follow-up period, 482 participants developed CVD events (324 cases of stroke and 209 of coronary heart disease). The multivariable-adjusted risk of CVD increased significantly among participants with dynapenic obesity compared with the reference group (HR 1.49, 95% CI 1.03-2.17). An analysis by age groups showed a further increase in the risk of CVD among participants with dynapenic obesity aged less than 65 years (HR 1.66, 95% CI 1.04-2.65). In mediation analyses for participants aged less than 65 years, serum hs-CRP was shown to be a significant mediator explaining 13.8% of the association between dynapenic obesity and the development of CVD, while HOMA-IR explained 12.2% of this relationship. CONCLUSIONS: Dynapenic obesity was a significant risk factor for the development of CVD in a general Japanese population. This association was more pronounced among those aged <65 years. Inflammation, and possibly glucose metabolism, might partly mediate this association. Our findings suggest that preventing muscle dysfunction as well as appropriate weight control, especially in middle-age, are important for preventing the development of CVD.

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  • Common protein-altering variant in GFAP is associated with white matter lesions in the older Japanese population. International journal

    Yoshihiko Furuta, Masato Akiyama, Naoki Hirabayashi, Takanori Honda, Mao Shibata, Tomoyuki Ohara, Jun Hata, Chikashi Terao, Yukihide Momozawa, Yasuko Tatewaki, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya

    NPJ genomic medicine   9 ( 1 )   59 - 59   2024.11   eISSN:2056-7944

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    The genetic architecture of white matter lesions (WMLs) in Asian populations has not been well-characterized. Here, we performed a genome-wide association study (GWAS) to identify loci associated with the WML volume. Brain MRI and DNA samples were collected from 9479 participants in the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD). The GWAS confirmed three known WML-associated loci (SH3PXD2A, GFAP, and TRIM47). The lead variant of GFAP was a common missense variant (p.D295N) in East Asians. Meta-GWAS using the publicly available summary statistics of UK Biobank identified one previously unreported locus 6q23.2 (SLC2A12). Integration with expression quantitative trait locus data implied the newly identified locus affects SLC2A12 expression. The effect sizes of 20 lead variants at the WML-associated loci were moderately correlated between JPSC-AD and UK Biobank. These results indicate that the alteration in GFAP protein caused by the common missense variant in East Asians influences the WML volume.

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  • Genetic Risk Stratification of Primary Open-Angle Glaucoma in Japanese Individuals

    Masato Akiyama, Gen Tamiya, Kohta Fujiwara, Yukihiro Shiga, Yu Yokoyama, Kazuki Hashimoto, Masataka Sato, Kota Sato, Akira Narita, Sawako Hashimoto, Emi Ueda, Yoshihiko Furuta, Jun Hata, Masahiro Miyake, Hanako O. Ikeda, Kenji Suda, Shogo Numa, Yuki Mori, Kazuya Morino, Yusuke Murakami, Sakurako Shimokawa, Shun Nakamura, Nobuyo Yawata, Kimihiko Fujisawa, Satoshi Yamana, Kenichiro Mori, Yasuhiro Ikeda, Kazunori Miyata, Keisuke Mori, Ken Ogino, Yoshito Koyanagi, Yoichiro Kamatani, Koichi Matsuda, Yuji Yamanashi, Yoichi Furukawa, Takayuki Morisaki, Yukinori Okada, Yoshinori Murakami, Kaori Muto, Akiko Nagai, Yusuke Nakamura, Wataru Obara, Ken Yamaji, Kazuhisa Takahashi, Satoshi Asai, Yasuo Takahashi, Shinichi Higashiue, Shuzo Kobayashi, Hiroki Yamaguchi, Yasunobu Nagata, Satoshi Wakita, Chikako Nito, Yu-Ki Iwasaki, Shigeo Murayama, Kozo Yoshimori, Yoshio Miki, Daisuke Obata, Masahiko Higashiyama, Akihide Masumoto, Yoshinobu Koga, Yukihiro Koretsune, Toshiharu Ninomiya, Koh-Hei Sonoda, Toru Nakazawa, Makoto Aihara, Rei Sakata, Kenji Kashiwagi, Fumihiko Mabuchi, Kazuhide Kawase, Takeshi Iwata, Motokazu Tsujikawa, Koji M. Nishiguchi

    Ophthalmology   131 ( 11 )   1271 - 1280   2024.11   ISSN:0161-6420 eISSN:1549-4713

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    Purpose: To assess the impact of genetic risk estimation for primary open-angle glaucoma (POAG) in Japanese individuals. Design: Cross-sectional analysis. Participants: Genetic risk scores (GRSs) were constructed based on a genome-wide association study (GWAS) of POAG in Japanese people. A total of 3625 Japanese individuals, including 1191 patients and 2434 controls (Japanese Tohoku), were used for the model selection. We also evaluated the discriminative accuracy of constructed GRSs in a dataset comprising 1034 patients and 1147 controls (the Japan Glaucoma Society Omics Group [JGS-OG] and the Genomic Research Committee of the Japanese Ophthalmological Society [GRC-JOS]) and 1900 participants from a population-based study (Hisayama Study). Methods: We evaluated 2 types of GRSs: polygenic risk scores using the pruning and thresholding procedure and a GRS using variants associated with POAG in the GWAS of the International Glaucoma Genetics Consortium (IGGC). We selected the model with the highest areas under the receiver operating characteristic curve (AUC). In the population-based study, we evaluated the correlations between GRS and ocular measurements. Main Outcome Measure: Proportion of patients with POAG after stratification according to the GRS. Results: We found that a GRS using 98 variants, which showed genome-wide significance in the IGGC, showed the best discriminative accuracy (AUC, 0.65). In the Japanese Tohoku, the proportion of patients with POAG in the top 10% individuals was significantly higher than that in the lowest 10% (odds ratio [OR], 6.15; 95% confidence interval [CI], 4.35–8.71). In the JGS-OG and GRC-JOS, we confirmed similar impact of POAG GRS (AUC, 0.64; OR [top vs. bottom decile], 5.81; 95% CI, 3.79–9.01). In the population-based study, POAG prevalence was significantly higher in the top 20% individuals of the GRS compared with the bottom 20% (9.2% vs. 5.0%). However, the discriminative accuracy was low (AUC, 0.56). The POAG GRS was correlated positively with intraocular pressure (r = 0.08: P = 4.0 × 10–4) and vertical cup-to-disc ratio (r = 0.11; P = 4.0 × 10–6). Conclusions: The GRS showed moderate discriminative accuracy for POAG in the Japanese population. However, risk stratification in the general population showed relatively weak discriminative performance. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

    DOI: 10.1016/j.ophtha.2024.05.026

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  • Skin carotenoid scores and metabolic syndrome in a general Japanese population: the Hisayama study. International journal

    Yasumi Kimura, Jun Hata, Mao Shibata, Takanori Honda, Satoko Sakata, Yoshihiko Furuta, Emi Oishi, Takanari Kitazono, Toshiharu Ninomiya

    International journal of obesity (2005)   48 ( 10 )   1465 - 1471   2024.10   ISSN:0307-0565 eISSN:1476-5497

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    BACKGROUND: Higher vegetable intake is being promoted as an initiative to prevent lifestyle-related diseases. Carotenoids are yellow or red pigment components and are widely present in vegetables. Since ingested carotenoids accumulate in the skin, skin carotenoid levels are a quantitative indicator of vegetable intake. Recently, noninvasive optical sensors for assessing skin carotenoid levels were developed. We here examined the association between skin carotenoid scores measured using optical sensors and the presence of metabolic syndrome. METHODS: A total of 1618 individuals (604 men and 1014 women) aged ≥ 40 years (mean age 63.1 years) participated in the study. Skin carotenoid scores were determined using a noninvasive optical sensor based on multiple spatially resolved reflectance spectroscopy. Metabolic syndrome was defined based on the Joint Scientific Statement criteria developed by six international scientific societies. Multivariable-adjusted logistic regression models were used. RESULTS: The prevalence of metabolic syndrome was 31.3% (n = 506). A remarkably strong association was found between higher skin carotenoid scores and lower prevalence of metabolic syndrome after adjusting for confounders. The multivariable-adjusted odds ratio for the presence of metabolic syndrome in individuals with the highest quartile of skin carotenoid scores was 0.39 (95% confidence interval, 0.28-0.55) compared to those with the lowest quartile. CONCLUSIONS: Our findings suggest that higher skin carotenoid scores measured by non-invasive optimal sensors are significantly associated with a lower likelihood of having metabolic syndrome in the general Japanese population.

    DOI: 10.1038/s41366-024-01575-7

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  • Glucose metabolism and smaller hippocampal volume in elderly people with normal cognitive function. International journal

    Ayano Shima, Moeko Noguchi-Shinohara, Shutaro Shibata, Yuta Usui, Yasuko Tatewaki, Benjamin Thyreau, Jun Hata, Tomoyuki Ohara, Takanori Honda, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Hisao Nishijo, Toshiharu Ninomiya, Kenjiro Ono

    npj aging   10 ( 1 )   39 - 39   2024.9   eISSN:2731-6068

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    We investigated associations of glycemic measures, and insulin resistance and secretion measures with hippocampal and subfield volumes. In this cross-sectional study, 7400 community-dwelling participants underwent brain MRI and health checkups between 2016 and 2018. Hemoglobin A1c (HbA1c), glycated albumin (GA), homeostasis model assessment for insulin resistance (HOMA-IR), and HOMA of percent β-cell function (HOMA-β) were evaluated. The associations of each measure with a smaller volume of the hippocampus and twelve hippocampal subfields were investigated. As a result, higher HbA1c or GA and lower HOMA-β levels were significantly associated with smaller volumes in multiple hippocampal subfields. Furthermore, even when we analyzed non-diabetic individuals, substantial associations remained between higher GA or lower HOMA-β levels and smaller volumes of the whole hippocampus or the fimbria. Our findings indicate that postprandial glucose fluctuations, postprandial hyperglycemia, and low insulin secretion have a specific effect on the development of smaller hippocampal volume, suggesting that primary prevention of diabetes and/or sufficient glucose control are important for the prevention of dementia.

    DOI: 10.1038/s41514-024-00164-2

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  • General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7•5 million participants

    Zhou, B; Bennett, JE; Wickham, AP; Singleton, RK; Mishra, A; Carrillo-Larco, RM; Ikeda, N; Jain, L; Barradas-Pires, A; Heap, RA; Lhoste, VPF; Sheffer, KE; Phelps, NH; Rayner, AW; Gregg, EW; Stevens, GA; Iurilli, MLC; Danaei, G; Di Cesare, M; Aguilar-Salinas, CA; Ahmad, NA; Bovet, P; Chen, ZM; Damasceno, A; Filippi, SL; Janszky, I; Kengne, AP; Khang, YH; Khunti, K; Laxmaiah, A; Lim, LL; Lissner, L; Margozzini, P; Mbanya, JC; McGarvey, S; Shaw, JE; Söderberg, S; Soto-Mota, LA; Wang, JY; Zaccardi, F; Ezzati, M; Abarca-Gómez, L; Abbasi-Kangevari, M; Abdrakhmanova, S; Ghaffar, SA; Rahim, HFA; Abdurrahmonova, Z; Abu-Rmeileh, NM; Acosta-Cazares, B; Adam, I; Adamczyk, M; Aekplakorn, W; Agdeppa, IA; Aghazadeh-Attari, J; Agyemang, C; Ahmad, MH; Ahmad, NA; Ahmadi, A; Ahmadi, N; Ahmadi, N; Ahmed, SH; Ahrens, W; Aitmurzaeva, G; Ajlouni, K; Al-Hazzaa, HM; Al-Hinai, H; Al-Lawati, JA; Al-Raddadi, R; Al Asfoor, D; Al Hourani, HM; Alarouj, M; AlBuhairan, F; AlDhukair, S; Ali, MM; Alieva, AV; Alkandari, A; Alkhatib, BM; Aly, E; Amarapurkar, DN; Etxezarreta, PA; Amougou, N; Andersen, LB; Anderssen, SA; Androutsos, O; Anjana, RM; Ansari-Moghaddam, A; Anufrieva, E; Aounallah-Skhir, H; Aris, T; Arku, RE; Arlappa, N; Aryal, KK; Assah, FK; Assembekov, B; Assunçao, MCF; Auvinen, J; Avdicová, M; Azad, K; Azevedo, A; Azimi-Nezhad, M; Azizi, F; Bacopoulou, F; Bahijri, S; Bajramovic, I; Balakrishna, N; Bamoshmoosh, M; Banach, M; Bandosz, P; Banegas, JR; Baran, R; Barbagallo, CM; Barbosa, V; Barceló, A; Baretic, M; Barnoya, J; Barrera, L; Barros, AJ; Barros, MVG; Basit, A; Bastos, JL; Batieha, AM; Batista, AP; Batista, RL; Battakova, Z; Baur, LA; Bayauli, PM; Bel-Serrat, S; Belavendra, A; Ben Romdhane, H; Benedek, T; Benedics, J; Benet, M; Rolandi, GEB; Benzeval, M; Bere, E; Berger, N; Bergh, IH; Berkinbayev, S; Bernabe-Ortiz, A; Bettiol, H; Beybey, AF; Bezerra, J; Bhagyalaxmi, A; Bhargava, SK; Lele, ECB; Bikbov, MM; Bista, B; Bjelica, DJ; Bjerregaard, P; Bjertness, E; Bjertness, MB; Björkelund, C; Bloch, KV; Blokstra, A; Bo, S; Bobak, M; Boddy, LM; Boehm, BO; Boggia, JG; Bogova, E; Bonaccio, M; Bonillavargas, A; Borghs, H; Botomba, S; Bourne, R; Boymatova, K; Braeckman, L; Braithwaite, T; Brajkovich, I; Branca, F; Brenner, H; Brewster, LM; Briceño, Y; Brinduse, L; Bringolf-Isler, B; Brito, M; Brug, J; Bugge, A; Buntinx, F; Buoncristiano, M; Burns, C; de León, AC; Caixeta, RB; Cama, T; Can, G; Cândido, APC; Cañete, F; Capanzana, MV; Capková, N; Capuano, E; Capuano, E; Capuano, V; Cardoso, VC; Carlsson, AC; Casanueva, FF; Casas, M; Censi, L; Cervantes-Loaiza, M; Chamnan, P; Chamukuttan, S; Chan, Q; Chaturvedi, N; Chen, FF; Chen, HH; Chen, LS; Chen, ZM; Cheng, YJ; Cheraghian, B; Chetrit, A; Chikova-Iscener, E; Chinapaw, MJ; Chinnock, A; Chiolero, A; Chirita-Emandi, A; Chirlaque, MD; Chong, CL; Christofaro, DG; Chudek, J; Cifkova, R; Cirillo, M; Claessens, F; Clare, P; Cohen, E; Confortin, SC; Coppinger, TC; Cortés, LY; Cosmin, CR; Costanzo, S; Cowan, MJ; Cowell, C; Crampin, AC; Cross, AJ; Crujeiras, AB; Cruz, JJ; Cucu, AM; Cureau, FV; Cuschieri, S; D'Arrigo, G; D'Orsi, E; da Silva-Ferreira, H; Dahm, CC; Dallongeville, J; Damasceno, A; Dankner, R; Davletov, K; de Vasconcelos, FDG; de Assis, MAA; De Bacquer, D; De Bacquer, J; de Bont, J; De Curtis, A; Hinnig, PD; de Gaetano, G; De Henauw, S; De Miguel-Etayo, P; de Oliveira, PD; de Paiva, KM; De Ridder, K; Correia, MAD Jr; Deepa, M; DeGennaro, VJ; Demarest, S; Dennison, E; Deschamps, V; Dhimal, M; Ripolles, MPD; Dika, Z; Djalalinia, S; Dominguez, L; Donati, MB; Donfrancesco, C; Dong, GH; Donoso, SP; Dorobantu, M; Dörr, M; Dragano, N; Drygas, W; Du, S; Duante, CA; Duboz, P; Duda, RB; Duleva, VL; Dushpanova, A; Dyussupova, A; Dziankowska-Zaborszczyk, E; Ebrahimi, N; Echeverría, G; Eddie, R; Eftekhar, E; Efthymiou, V; Egbagbe, EE; Eghtesad, S; Ekelund, U; El-Khateeb, M; El Ati, J; Elosua, R; Enang, O; Erasmus, RT; Erem, C; Ergor, G; Eriksen, L; Eriksson, JG; Escobedo-de la Peña, JED; Esmaeili, A; Evans, RG; Fakhradiyev, I; Fakhretdinova, AA; Fall, CH; Faramarzi, E; Farjam, M; Farzadfar, F; Farzi, Y; Fattahi, MR; Fawwad, A; Felix-Redondo, FJ; Ferguson, TS; Fernandes, RA; Fernández-Bergés, D; Fernando, DR; Ferrante, D; Ferrari, G; Ferrari, M; Ferreccio, C; Ferrer, E; Figueiró, TH; Fijalkowska, A; Fink, G; Fisberg, M; Forsner, M; Fottrell, EF; Fouad, HM; Francis, DK; Frontera, G; Fuchs, FD; Fuchs, SC; Furdela, V; Furusawa, T; Gabriela, SA; Gaciong, Z; Cuesta, MG; Galbarczyk, A; Galcheva, SV; Galfo, M; Garcia-De-La-Hera, M; Garcia, P; Garnett, SP; Gasull, M; Gazzinelli, A; Gehring, U; Gerdts, E; Ghaderi, E; Ghamari, SH; Ghanbari, A; Ghasemi, E; Gheorghe-Fronea, OF; Ghimire, A; Gialluisi, A; Giampaoli, S; Gianfagna, F; Gironella, G; Giwercman, A; Gkiouras, K; Glushkova, N; Godara, R; Godos, J; Goldberg, M; Gómez, G; Gómez, JHG; Gomez, LF; Gómez, SF; Gomula, A; da Silva, BGC; Gonçalves, H; Gonçalves, M; González-Alvarez, AD; Gonzalez-Chica, DA; González-Gil, EM; Gonzalez-Gross, M; González-Rivas, JP; Gonzalez, AR; Gottrand, F; Grafnetter, D; Grajda, A; Grammatikopoulou, MG; Grodzicki, T; Groholt, EK; Grontved, A; Guajardo, V; Guallar-Castillón, P; Guerchet, M; Guerrero, R; Guimaraes, AL; Gujral, UP; Gulliford, MC; Gunter, MJ; Gupta, R; Gureje, O; Gurinovic, MA; Gurzkowska, B; Gutierrez, L; Gwee, X; Haghshenas, R; Hakimi, H; Halkjær, J; Hambleton, IR; Hamzeh, B; Hanekom, WA; Hange, D; Hanif, AA; Hantunen, S; Hao, J; Hardman, CM; Hardy, L; Kumar, RH; Harooni, J; Hashemi-Shahr, SM; Hassapidou, M; Hata, J; Haugsgjerd, T; Heinen, M; Hendriks, ME; Henrique, RD; Henriques, A; Cadena, LH; Herrala, S; Herrera-Cuenca, M; Herrera, VM; Herter-Aeberli, I; Herzig, KH; Heshmat, R; Hill, AG; Ho, SY; Holdsworth, M; Homayounfar, R; Homs, C; Hoogendijk, EO; Horimoto, AR; Hormiga, CM; Horta, BL; Houti, L; Howitt, C; Htay, TT; Htet, AS; Htike, MMT; Huerta, JM; Huhtaniemi, IT; Huiart, L; Petrescu, CH; Huisman, M; Husseini, A; Huybrechts, I; Hwalla, N; Iacoviello, L; Iakupova, EM; Iannone, AG; Igland, J; Ijoma, C; Ikeda, N; Iotova, V; Irazola, VE; Ishida, T; Isiguzo, GC; Islam, M; Islam, SMS; Islek, D; Ittermann, T; Ivanova-Pandourska, IY; Iwasaki, M; Jääskeläinen, T; Jackson, RT; Jaddou, HY; Jadoul, M; Jafar, T; Jan, N; Janszky, I; Janus, E; Jarani, J; Jarnig, G; Jarvelin, MR; Jasienska, G; Jelakovic, A; Jelakovic, B; Jha, AK; Jimenez, RO; Jöckel, KH; Joffres, M; Jokelainen, JJ; Jonas, JB; Joshi, P; Joshi, R; Josipovic, J; Joukar, F; Józwiak, JJ; Juolevi, A; Juresa, V; Kaaks, R; Kaducu, FO; Kadvan, AL; Kafatos, A; Kajantie, EO; Kakutia, N; Kállayová, D; Kalmatayeva, Z; Kalte-Leibovici, O; Kannan, S; Kapantais, E; Karaglani, E; Karakosta, A; Karki, KB; Anicet, AK; Katibeh, M; Katulanda, P; Katzmarzyk, PT; Kauhanen, J; Kazakbaeva, GM; Kaze, FF; Ke, C; Keinänen-Kiukaanniemi, S; Kelishadi, R; Kelleher, C; Kemper, HCG; Kengne, AP; Keramati, M; Kersting, M; Khader, YS; Khaledifar, A; Khalili, D; Khang, YH; Kheiri, B; Kheradmand, M; Khosravi, A; Kiechl-Kohlendorfer, U; Kiechl, SJ; Kiechl, S; Kim, HC; Klakk, H; Klanarong, S; Klanova, J; Klimek, M; Knoflach, M; Kobel, S; Koirala, B; Kolle, E; Kolsteren, P; König, J; Korpelainen, R; Korrovits, P; Korzycka, M; Kos, J; Koskinen, S; Simone, MK; Kovács, É; Kovalskys, I; Kowlessur, S; Koziel, S; Kratenova, J; Kratzer, W; Kriemler, S; Kristensen, PL; Krizan, H; Kroker-Lobos, MF; Krokstad, S; Kruger, HS; Kruger, R; Kryst, L; Kubinova, R; Kujala, UM; Kujundzic, E; Kulaga, Z; Kulimbet, M; Kumari, M; Kunesová, M; Kurjata, P; Kyobutungi, C; La, QN; Labadarios, D; Lachat, C; Lai, D; Laid, Y; Lall, L; Jimenez, ML; Landais, E; Lankila, T; Lanska, V; Lappas, G; Larijani, B; Lateva, MP; Latt, TS; Laurenzi, M; Lazo-Porras, M; Le Coroller, G; Bao, KL; Lehtimäki, T; Lemogoum, D; Leong, E; Leszczak, J; Leung, GM; Li, YP; Liivak, M; Lim, C; Lim, WY; Lima-Costa, MF; Lin, HH; Lind, L; Litwin, M; Liu, LP; Liu, XT; Abril, GL; Lopes, O; Lopez-Garcia, E; López-Gil, JF; Lopez, T; Lozano, JE; Lukrafk, JL; Luksiene, D; Lundqvist, A; Lunet, N; Lunogelo, C; Lustigová, M; M'Buyamba-Kabangu, JR; Machado-Coelho, GLL; Machado-Rodrigues, AM; Macia, E; Madar, AA; Maestre, GE; Maggi, S; Magliano, DJ; Magnacca, S; Magriplis, E; Mahasampath, G; Maire, B; Makdisse, M; Malekpour, MR; Malekzadeh, F; Malekzadeh, R; Rao, KM; Malyutina, S; Maniego, LV; Manios, Y; Mann, JI; Mansour-Ghanaei, F; Manzato, E; Mapatano, MA; Margozzini, P; Maria-Magdalena, R; Mariño, J; Markaki, A; Marques, LP; Marrugat, J; Martorell, R; Maruszczak, K; Masala, G; Mascarenhas, LP; Imani, MM; Masinaei, M; Mathiesen, EB; Matijasevich, A; Matlosz, P; Matsha, TE; Matsudo, V; Matteo, G; Maulik, PK; Mavrogianni, C; Mbanya, JCN; Posso, AJMD; McFarlane, SR; McGarvey, ST; McLean, RM; Benchekor, SM; Mehlig, K; Mehrparvar, AH; Melgarejo, JD; Méndez, F; Mendivil, CO; Montano, CM; Menezes, AMB; Mensink, GBM; Mereke, A; Meshram, II; Meto, DT; Meyer, HE; Mi, J; Milkowska, K; Miller, JC; Milushkina, O; Minderico, CS; Mini, GK; Miquel, JF; Miranda, JJ; Mirjalili, MR; Misigoj-Durakovic, M; Mistretta, A; Mocanu, V; Modesti, PA; Moghaddam, SS; Mohammad, K; Mohammadi, MR; Mohammadi, Z; Mohammadifard, N; Mohammadpourhodki, R; Mohan, V; Yusoff, MFM; Mohebbi, I; Moller, NC; Molnár, D; Momenan, A; Mondo, CK; Monroy-Valle, MM; Mendoza, RAM; Monterrubio-Flores, E; Monyeki, KDK; Moon, JS; Moosazadeh, M; Moradpour, F; Moreira, LB; Morejon, A; Moreno, LA; Morgan, K; Moschonis, G; Moslem, A; Mosquera, M; Mossakowska, M; Mostafa, A; Mostafavi, SA; Motlagh, ME; Motta, J; Moura-Dos-Santos, MA; Mridha, MK; Msyamboza, KP; Mu, TT; Muca, F; Mugosa, B; Munroe, PB; Mursu, J; Musa, KI; Milanovic, SM; Musil, V; Musinguzi, G; Mustafa, N; Muyer, MTMC; Nabipour, I; Naidu, BM; Najafi, F; Nalecz, H; Námesná, J; Narayan, KV; Naseri, T; Nathalie, M; Neelapaichit, N; Nejatizadeh, A; Nenko, I; Nervi, F; Neuhauser, HK; Ng, TP; Nguyen, CT; Nguyen, QV; Nguyen, QN; Ni, MY; Nie, P; Nieto-Martínez, RE; Niiranen, TJ; Ninomiya, T; Nishi, N; Nishtar, S; Noale, M; Noboa, OA; Norton, KI; Noto, D; Nowak-Szczepanska, N; Al Nsour, M; Nuhoglu, I; Nurk, E; Nuwaha, F; Nyirenda, M; O'Neill, TW; Ochimana, C; Ochoa-Avilés, AM; Oda, E; Odili, AN; Oh, K; Ohtsuka, R; Oldenburg, B; Olié, V; Omar, MA; Omar, SM; Onat, A; Ong, SK; Onland-Moret, NC; Ono, LM; Onodugo, O; Ordunez, P; Ornelas, R; Ortiz, AP; Ortiz, PJ; Osmond, C; Ostojic, SM; Ostovar, A; Otero, JA; Ottendahl, CB; Otu, A; Overvad, K; Owusu-Dabo, E; Padez, CP; Pagkalos, I; Pajula, N; Palloni, A; Palmieri, L; Pan, WH; Panza, F; Paoli, M; Papadopoulou, SK; Pareja, RG; Park, SW; Park, S; Parnell, WR; Parsaeian, M; Pascanu, IM; Pasquet, P; Patel, ND; Pavlyshyn, H; Pechlaner, R; Pecin, I; Pedro, JM; Peixoto, SV; Peltonen, M; Pereira, AC; Peres, KGDA; Peres, MA; Perez-Londoño, A; Pérez, CM; Peterkova, V; Kovtun, OP; Peykari, N; Pham, ST; Pichardo, RN; Pierre-Marie, P; Pikhart, H; Pilav, A; Piler, P; Piwonska, A; Pizarro, AN; Plata, S; Pop, RM; Popkin, BM; Popovic, SR; Porta, M; Poudyal, A; Pourfarzi, F; Pourshams, A; Poustchi, H; Pradeepa, R; Price, AJ; Prista, A; Providencia, R; Puder, JJ; Pudule, I; Puhakka, S; Puiu, M; Punab, M; Qorbani, M; Quialheiro, A; Quintana, HK; Quiroga-Padilla, PJ; Bao, TQ; Rach, S; Rahimikazerooni, S; Rahman, M; Raitakari, O; Rakhmatulloev, S; Rakovac, I; Ramachandran, A; Ramadan, OPC; Ramirez-Zea, M; Ramos, R; Rampal, L; Rampal, S; Ramsay, SE; Rangel, JF Jr; Reina, DAR; Rangelova, LS; Rarra, V; Rashidi, MM; Rech, CR; Redon, J; Regecová, V; Renner, JD; Repasy, JA; Revilla, L; Reynolds, A; Rezaei, N; Rezaianzadeh, A; Riboli, E; Rigo, F; Rigotti, A; Riley, LM; de Wit, TFR; Risérus, U; Ritti-Dias, RM; Roa, RG; Roccaldo, R; Rodríguez-Artalejo, F; Rodriguez-Perez, MD; Rodríguez-Villamizar, LA; Rodríguez, AY; Roggenbuck, U; Rohloff, P; Rojas-Martinez, R; Romeo, EL; Rosario, RV; Rosengren, A; Rouse, I; Rubinstein, A; Ruiz-Betancourt, BS; Ruiz-Castell, M; Moreno, ER; Rusakova, IA; Rusek, W; Rust, P; Rutkowski, M; Saamel, M; Sabbaghi, H; Sachdev, HS; Sadjadi, A; Safarpour, AR; Safi, S; Saghi, MH; Saidi, O; Saieva, C; Sakata, S; Saki, N; Salaj, S; Martinez, ES; Salkhanova, A; Salonen, JT; Samoutian, M; Sánchez-Abanto, J; Rodríguez, IS; Santos, DA; Santos, IS; Santos, MP; Santos, TR; Saramies, JL; Sardinha, LB; Sarganas, G; Sarrafzadegan, N; Saum, KU; Savin, S; Sbaraini, M; Scazufca, M; Schaan, BD; Schienkiewitz, A; Schindler, K; Schipf, S; Schmidt, AF; Schmidt, B; Schmidt, CO; Schöttker, B; Schramm, S; Schramm, S; Schröder, H; Schultsz, C; Schutte, AE; Sebert, S; Sedaghattalab, M; Sein, AA; Sen, A; Sepanlou, SG; Sequera, G; Sevcíková, L; Sewpaul, R; Shamah-Levy, T; Shamshirgaran, SM; Sharafkhah, M; Sharma, SK; Sharman, A; Shaw, JE; Shayanrad, A; Shayesteh, AA; Shengelia, L; Shibuya, K; Shimizu-Furusawa, H; Shiri, R; Shoranov, M; Shrestha, N; Si-Ramlee, K; Sibai, AM; Sidossis, LS; Silva, AM; Silva, CRD; Silva, DAS; Silva, KS; Sim, XL; Simon, M; Sjöström, M; Skoblina, NA; Slowikowska-Hilczer, J; Slusarczyk, P; Smeeth, L; Smith, L; Soares, FC; Sobek, G; Sobngwi, E; Sodemann, M; Söderberg, S; Soemantri, A; Solfrizz, V; Somi, MH; Sorgjerd, EP; Soric, M; Soto-Rojas, VE; Soumaré, A; Sousa-Poza, A; Spiroski, I; Staessen, JA; Stang, A; Steene-Johannessen, J; Stehle, P; Stein, AD; Stergiou, GS; Stokwiszewski, J; Stoyanova, E; Stratton, G; Stronks, K; Sturua, L; Suarez-Ortegón, MF; Suebsamran, P; Sulo, G; Sundström, J; Suriyawongpaisal, P; Swinburn, BA; Sylva, RC; Szponar, L; Tai, ES; Tambalis, KD; Tamosiunas, A; Tanabayev, B; Tanrygulyyeva, M; Tarawneh, MR; Tarp, J; Tarqui-Mamani, CB; Braunerová, RT; Velde, ST; Tebar, WR; Tell, GS; Tello, T; Thankappan, KR; Theodoridis, X; Thirunavukkarasu, S; Thomas, N; Thrift, AG; Tichá, L; Timmermans, EJ; Tjandrarini, DH; Tjonneland, A; Tolstrup, JS; Topbas, M; Torres-Collado, L; Touloumi, G; Traissac, P; Triantafyllou, A; Trivedi, A; Tshepo, L; Tsintavis, P; Tuitele, J; Tuliakova, AM; Tulloch-Reid, MK; Tullu, F; Tuomainen, TP; Turley, ML; Tzala, E; Tzotzas, T; Tzourio, C; Ueda, P; Ugel, E; Ukoli, FAM; Usupova, Z; Uusitalo, HMT; Uysal, N; Valdivia, G; Valvi, D; van Dam, RM; van den Born, BJ; Van der Heyden, J; van der Schouw, YT; Van Lippevelde, W; Van Minh, H; Van Schoor, NM; van Valkengoed, IGM; Vanderschueren, D; Vanuzzo, D; Varela-Moreiras, G; Vargas, LN; Vasan, SK; Vasques, DG; Vega, T; Velasquez-Melendez, G; Velika, B; Verdot, C; Verloigne, M; Veronesi, G; Verschuren, WMM; Verstraeten, R; Viet, L; Vik, FN; Vilar, M; Villalpando, S; Vioque, J; Virtanen, JK; Visser, M; Viswanathan, B; Vladulescu, M; Völzke, H; Voutilainen, A; Vrijheid, M; Wade, AN; Bebakar, WMW; Mohamud, WNW; Wanderley, RD Jr; Wang, CJ; Wang, HJ; Wang, NL; Wang, Q; Wang, XJ; Wang, YX; Wang, YW; Wannamethee, SG; Wareham, N; Wartha, O; Weber, A; Webster-Kerr, K; Wedderkopp, N; Weghuber, D; Wei, WB; Westbury, L; Whincup, PH; Wickramasinghe, K; Widhalm, K; Widyahening, IS; Wiecek, A; Wilks, RJ; Willeit, K; Willeit, P; Williams, J; Wilsgaard, T; Wojtyniak, B; Wong-McClure, RA; Wong, A; Wong, EB; Woodward, M; Wu, FC; Wyszynska, J; Xu, HQ; Xu, L; Yaacob, NA; Yan, L; Yan, W; Yang, Y; García, MY; Yoosefi, M; Yoshihara, A; Younger-Coleman, NO; Yu, YL; Yu, YJ; Yusof, AF; Zafiropulos, V; Zainuddin, AA; Zamani, F; Zambon, S; Zampelas, A; Zapata, ME; Zaw, KK; Zdrojewski, T; Zeglen, M; Zejglicova, K; Vrkic, TZ; Zhang, B; Zhang, ZY; Zhecheva, YV; Zholdin, B; Zimmet, P; Zins, M; Cisneros, JZ; Zuziak, M

    LANCET   404 ( 10455 )   851 - 863   2024.8   ISSN:0140-6736 eISSN:1474-547X

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    Background: Adiposity can be measured using BMI (which is based on weight and height) as well as indices of abdominal adiposity. We examined the association between BMI and waist-to-height ratio (WHtR) within and across populations of different world regions and quantified how well these two metrics discriminate between people with and without hypertension. Methods: We used data from studies carried out from 1990 to 2023 on BMI, WHtR and hypertension in people aged 20–64 years in representative samples of the general population in eight world regions. We graphically compared the regional distributions of BMI and WHtR, and calculated Pearson's correlation coefficients between BMI and WHtR within each region. We used mixed-effects linear regression to estimate the extent to which WHtR varies across regions at the same BMI. We graphically examined the prevalence of hypertension and the distribution of people who have hypertension both in relation to BMI and WHtR, and we assessed how closely BMI and WHtR discriminate between participants with and without hypertension using C-statistic and net reclassification improvement (NRI). Findings: The correlation between BMI and WHtR ranged from 0·76 to 0·89 within different regions. After adjusting for age and BMI, mean WHtR was highest in south Asia for both sexes, followed by Latin America and the Caribbean and the region of central Asia, Middle East and north Africa. Mean WHtR was lowest in central and eastern Europe for both sexes, in the high-income western region for women, and in Oceania for men. Conversely, to achieve an equivalent WHtR, the BMI of the population of south Asia would need to be, on average, 2·79 kg/m2 (95% CI 2·31–3·28) lower for women and 1·28 kg/m2 (1·02–1·54) lower for men than in the high-income western region. In every region, hypertension prevalence increased with both BMI and WHtR. Models with either of these two adiposity metrics had virtually identical C-statistics and NRIs for every region and sex, with C-statistics ranging from 0·72 to 0·81 and NRIs ranging from 0·34 to 0·57 in different region and sex combinations. When both BMI and WHtR were used, performance improved only slightly compared with using either adiposity measure alone. Interpretation: BMI can distinguish young and middle-aged adults with higher versus lower amounts of abdominal adiposity with moderate-to-high accuracy, and both BMI and WHtR distinguish people with or without hypertension. However, at the same BMI level, people in south Asia, Latin America and the Caribbean, and the region of central Asia, Middle East and north Africa, have higher WHtR than in the other regions. Funding: UK Medical Research Council and UK Research and Innovation (Innovate UK).

    DOI: 10.1016/S0140-6736(24)01405-3

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  • 剖検にて確認された冠動脈アテローム硬化症における血管石灰化とプラーク内出血の関連性 久山町研究(Association between Vascular Calcification and Intraplaque Hemorrhage in Coronary Atherosclerosis from Autopsy: The Hisayama Study)

    Nakano Toshiaki, Kitamura Hiromasa, Hata Jun, Maki Kenji, Oda Yoshinao, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   31 ( 8 )   1225 - 1237   2024.8   ISSN:1340-3478

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    1988年1月~2005年11月に死亡した久山町住民のうち126名(男性49名)の剖検で得られた374の冠動脈を用いて、血管石灰化とプラーク内出血の関連性を評価した。149の冠動脈に石灰化病変が認められ、いずれも内膜にみられた。石灰化面積が第4五分位であった動脈では石灰化がなかった動脈と比較してプラーク内出血を有する確率が有意に高かった(p<0.001)。交絡因子について補正後のオッズ比(OR)は13.13(95%CI 2.97~58.16)であった。マクロファージ浸潤の影響を評価した結果、マクロファージ浸潤面積の増加に伴ってプラーク内出血の頻度が有意に増加した。マクロファージ浸潤面積が最も大きく、石灰化面積が中等度(第4五分位)の場合にプラーク内出血のORが最も大きかった。血管新生の影響を評価した結果、血管数の増加に伴ってプラーク内出血の頻度が有意に増加した。プラーク内出血のORは石灰化の存在と血管数により相加的に増加した。以上の結果から、血管石灰化はプラーク内出血と有意に関連し、その関連性は石灰化が一定の面積を超えると低下することが示唆された。

  • 日本人地域高齢住民におけるpreserved ratio impaired spirometryと認知症発症との関連 久山町研究(Risks of Dementia in a General Japanese Older Population With Preserved Ratio Impaired Spirometry: The Hisayama Study)

    Kawatoko Kenji, Washio Yasuyoshi, Ohara Tomoyuki, Fukuyama Satoru, Honda Takanori, Hata Jun, Nakazawa Taro, Kan-o Keiko, Inoue Hiromasa, Matsumoto Koichiro, Nakao Tomohiro, Kitazono Takanari, Okamoto Isamu, Ninomiya Toshiharu

    Journal of Epidemiology   34 ( 7-8 )   331 - 339   2024.8   ISSN:0917-5040

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    <Highlight>●preserved ratio impaired spirometry(PRISm)と認知症との関連は明らかにされていない。●本研究では、認知症のない65歳以上の日本人地域高齢住民1,202人を対象に、中央値5.0年間の追跡調査を行った。●PRISm群は、呼吸機能正常群と比べ認知症の発症リスクが約2倍であった。●PRISmは、認知症の発症リスクが高い集団であり、呼吸機能障害の重要なサブタイプといえる。(著者抄録)

  • Association of sarcopenia with regional brain atrophy and white matter lesions in a general older population: the Hisayama Study. International journal

    Takahiro Tajimi, Naoki Hirabayashi, Yoshihiko Furuta, Taro Nakazawa, Takanori Honda, Jun Hata, Tomoyuki Ohara, Mao Shibata, Takanari Kitazono, Yasuharu Nakashima, Toshiharu Ninomiya

    GeroScience   47 ( 1 )   1187 - 1198   2024.7   ISSN:2509-2715 eISSN:2509-2723

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    Sarcopenia has been reported to be associated with cognitive decline and the risk of dementia. However, few studies have addressed the association between sarcopenia and brain morphological changes in the general population. A total of 1373 community-dwelling participants aged ≥ 65 years underwent brain MRI. Sarcopenia was defined based on the Asian Working Group for Sarcopenia's criteria. The pattern of regional gray matter volume loss associated with sarcopenia were assessed using a voxel-based morphometry (VBM) analysis. Regional brain volumes, intracranial volumes (ICV), and white matter lesions volumes (WMLV) were also measured using FreeSurfer. An analysis of covariance was used to examine the associations of sarcopenia with regional brain volumes in proportion to ICV. Of the participants, 112 had sarcopenia. The participants with sarcopenia had significantly lower total brain volume/ICV and total gray matter volume/ICV and higher WMLV/ICV than those without sarcopenia after adjusting for confounders. In VBM, sarcopenia was associated with lower gray matter volume in the frontal lobe, insula, cingulate gyrus, hippocampus, amygdala, and basal ganglia. Using FreeSurfer, we confirmed that the participants with sarcopenia had significantly lower frontal, insular, cingulate, and hippocampal volumes than those without sarcopenia. The current study showed that participants with sarcopenia had significantly lower volume in the frontal lobe, insula, cingulate, and hippocampus and higher WMLV than participants without sarcopenia. As these brain regions are likely to play an important role in cognitive function, these changes may suggest a shared underlying mechanism for the progression of sarcopenia and cognitive decline.

    DOI: 10.1007/s11357-024-01289-8

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  • 特集 "とりあえずスタチン"から脱却!-動脈硬化性疾患一次予防・最新の考え方 疫学 動脈硬化性疾患(脳梗塞を含む)の疫学

    秦 淳

    medicina   61 ( 8 )   1202 - 1206   2024.7   ISSN:00257699 eISSN:18821189

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    Publisher:株式会社医学書院  

    DOI: 10.11477/mf.1402229666

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  • Risks of Dementia in a General Japanese Older Population With Preserved Ratio Impaired Spirometry: The Hisayama Study

    Kawatoko Kenji, Washio Yasuyoshi, Ohara Tomoyuki, Fukuyama Satoru, Honda Takanori, Hata Jun, Nakazawa Taro, Kan-o Keiko, Inoue Hiromasa, Matsumoto Koichiro, Nakao Tomohiro, Kitazono Takanari, Okamoto Isamu, Ninomiya Toshiharu

    Journal of Epidemiology   34 ( 7 )   331 - 339   2024.7   ISSN:09175040 eISSN:13499092

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japan Epidemiological Association  

    <p><b>Background:</b> Studies on the association between preserved ratio impaired spirometry (PRISm) and dementia are limited. Indeed, PRISm has often been overlooked or ignored as an index of lung function impairment. Therefore, we investigated the association of PRISm with the risk for the development of dementia in an older Japanese population.</p><p><b>Methods:</b> A total of 1,202 community-dwelling, older Japanese participants aged ≥65 years without dementia were followed up for a median of 5.0 years. Participants were categorized by spirometry as follows: normal spirometry (FEV<sub>1</sub>/FVC ≥0.70 and FEV<sub>1</sub> ≥80% predicted), PRISm (≥0.70 and <80%), airflow limitation (AFL) Global Initiative for Chronic Obstructive Lung Disease (GOLD) 1 (<0.70 and ≥80%), and AFL GOLD 2 to 4 (<0.70 and <80%). Hazard ratios (HRs) and their 95% confidence intervals (CIs) were computed using a Cox proportional hazards model.</p><p><b>Results:</b> During the follow-up period, 122 participants developed dementia. The age- and sex-adjusted incidences of dementia in the participants with normal spirometry, PRISm, AFL GOLD 1, and AFL GOLD 2 to 4 were 20.5, 37.0, 18.4, and 28.6 per 1,000 person-years, respectively. Participants with PRISm had a higher risk of dementia (HR 2.04; 95% CI, 1.19–3.49) than those with normal spirometry after adjusting for confounders. Moreover, both reduced FEV<sub>1</sub>% predicted values and FVC% predicted values were associated with the risk of dementia.</p><p><b>Conclusion:</b> PRISm was associated with an increased risk of dementia in a general older Japanese population.</p>

    DOI: 10.2188/jea.je20230207

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  • 認知症の血漿バイオマーカーと部位別脳容積変化率との関連

    中澤 太郎, 小原 知之, 秦 淳, 本田 貴紀, 柴田 舞欧, 三上 達也, 前田 哲也, 小野 賢二郎, 三村 將, 中島 健二, 伊賀 淳一, 竹林 実, 徳田 隆彦, 二宮 利治

    老年精神医学雑誌   35 ( 増刊II )   206 - 206   2024.7   ISSN:0915-6305

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  • Descriptive epidemiology of muscle-strengthening activities in Japanese middle-aged and older adults: the Hisayama Study.

    Honda T, Hata J, Shibata M, Sakata S, Furuta Y, Oishi E, Kitazono T, Ninomiya T

    BMJ public health   2 ( 1 )   e000186   2024.6

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    DOI: 10.1136/bmjph-2023-000186

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  • 地域在住日本人高齢者における認知症発症予測のための血漿バイオマーカー(Plasma biomarkers for predicting the development of dementia in a community-dwelling older Japanese population)

    Ohara Tomoyuki, Tatebe Harutsugu, Hata Jun, Honda Takanori, Shibata Mao, Matsuura Sayo, Mikami Tatsuya, Maeda Tetsuya, Ono Kenjiro, Mimura Masaru, Nakashima Kenji, Iga Jun-ichi, Takebayashi Minoru, Tokuda Takahiko, Ninomiya Toshiharu, JPSC-AD(Japan Prospective Studies Collaboration for Aging and Dementia) study group

    Psychiatry and Clinical Neurosciences   78 ( 5-6 )   362 - 371   2024.6   ISSN:1323-1316

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    Language:English   Publisher:John Wiley & Sons Australia, Ltd  

    血漿中Aβ42/40、リン酸化タウ(p-t181)、GFAP、ニューロフィラメント軽鎖(NfL)と認知症リスクとの関連を評価し、これらのバイオマーカーが認知症発症予測能を向上させるかどうか検討した。65歳以上の認知症でない地域在住日本人1346名を5年間前向きに追跡し、血漿バイオマーカーを測定した。Cox比例ハザードモデルを用いて、各バイオマーカーと認知症リスクとのハザード比を推定した。その結果、追跡期間中に151名が認知症を発症し、そのうち108名がアルツハイマー型認知症(AD)、3名が非アルツハイマー型認知症(non-AD)であった。低Aβ42/40および高p-t181はADリスクと有意に関連していたが、non-ADとは関連がなかった。GFAPおよびNfLはADおよびnon-ADのリスクの両方と有意に関連していた。これらのバイオマーカーを認知症リスクモデルに加えることで、発症予測精度が有意に向上した。以上の結果から、Aβ42/40およびp-t181はADの特異的マーカー、GFAPおよびNfLはall-cause dementiaの有力なバイオマーカーであり、これらの測定は臨床で認知症ハイリスク群の特定に有用であることが示唆された。

  • Plasma biomarkers for predicting the development of dementia in a community-dwelling older Japanese population. International journal

    Tomoyuki Ohara, Harutsugu Tatebe, Jun Hata, Takanori Honda, Mao Shibata, Sayo Matsuura, Tatsuya Mikami, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Takahiko Tokuda, Toshiharu Ninomiya

    Psychiatry and clinical neurosciences   78 ( 6 )   362 - 371   2024.6   ISSN:1323-1316 eISSN:1440-1819

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    AIM: To assess the association between plasma amyloid β (Aβ) 42/40, phosphorylated tau (p-τ)181, glial fibrillary acidic protein (GFAP), or neurofilament light chain (NfL) and the risk of dementia and to determine whether these plasma biomarkers could improve the ability to predict incident dementia in a general older population. METHODS: A total of 1346 Japanese community-dwelling individuals aged ≥65 years without dementia were followed prospectively for 5.0 years. Plasma biomarkers were quantified using a Simoa HD-X analyzer. A Cox proportional hazards model was used to estimate the hazard ratios of each plasma biomarker level for the risk of dementia. RESULTS: During the follow-up, 151 participants developed dementia, of whom 108 had Alzheimer disease (AD) and 43 non-Alzheimer dementia (non-AD). Lower plasma Aβ42/40 levels and higher plasma p-τ181 levels were significantly associated with developing AD but not non-AD, whereas significant associations were observed between higher plasma levels of GFAP and NfL and risk of both AD and non-AD (all P for trend <0.05). In addition, adding these four plasma biomarkers into a model consisting of the total score of the dementia risk model significantly improved the predictive ability for incident dementia. CONCLUSION: Our findings suggest that plasma Aβ42/40 and p-τ181 are specific markers of AD, and plasma GFAP and NfL are potential biomarkers for all-cause dementia in the general Japanese older population. In addition, the measurement of these plasma biomarkers may be a useful and relatively low-invasive procedure for identifying individuals at high risk for developing dementia in clinical practice.

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  • Association between retinopathy and risk of dementia in a general Japanese population: the Hisayama Study

    Shun Nakamura, Emi Ueda, Tomoyuki Ohara, Jun Hata, Takanori Honda, Kohta Fujiwara, Yoshihiko Furuta, Mao Shibata, Sawako Hashimoto, Taro Nakazawa, Tomohiro Nakao, Takanari Kitazono, Koh-Hei Sonoda, Toshiharu Ninomiya

    Scientific Reports   14 ( 1 )   12017   2024.5   ISSN:2045-2322 eISSN:2045-2322

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    Abstract

    We investigated the association of retinopathy with the risk of dementia in a general older Japanese population. A total of 1709 population-based residents aged 60 years or older without dementia were followed prospectively for 10 years (2007–2017). They underwent color fundus photography in 2007. Retinopathy was graded according to the Modified Airlie House Classification. Main outcome was the Incidence of dementia. A Cox proportional hazards model was used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) for the risk of dementia by the presence of retinopathy. During the follow-up period, 374 participants developed all-cause dementia. The cumulative incidence of dementia was significantly higher in those with retinopathy than those without (p &lt; 0.05). Individuals with retinopathy had significantly higher risk of developing dementia than those without after adjustment for potential confounding factors (HR 1.64, 95% CI 1.19–2.25). Regarding the components of retinopathy, the presence of microaneurysms was significantly associated with a higher multivariable-adjusted HR for incident dementia (HR 1.94, 95% CI 1.37–2.74). Our findings suggest that, in addition to systemic risk factors, retinal microvascular signs from fundus photography provide valuable information for estimating the risk of developing dementia.

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  • Association Between Serum NT-proBNP and Gray Matter Atrophy Patterns in an Older Japanese Population: The Hisayama Study. International journal

    Naoki Hirabayashi, Jun Hata, Yoshihiko Furuta, Taro Nakazawa, Tomoyuki Ohara, Mao Shibata, Fumio Yamashita, Takanari Kitazono, Nobuyuki Sudo, Toshiharu Ninomiya

    The journals of gerontology. Series A, Biological sciences and medical sciences   79 ( 5 )   2024.5   ISSN:1079-5006 eISSN:1758-535X

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    Several population-based studies have reported that higher serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels are associated with brain morphological changes. However, no population-based studies have examined the relationship between serum NT-proBNP and various regional brain volumes in detail. We here analyzed the brain MRI data of 1 201 community-dwelling Japanese aged ≥65 years. Regional gray matter volumes (GMV) and intracranial volume (ICV) were estimated by applying voxel-based morphometry (VBM) methods. The associations of serum NT-proBNP with regional GMV/ICV were examined by analysis of covariance. The regional gray matter atrophy patterns associated with elevated serum NT-proBNP levels were investigated using VBM without a priori regions of interest. The multivariable-adjusted means of the frontal, temporal, hippocampal, parahippocampal, and entorhinal GMV/ICV decreased significantly with elevated serum NT-proBNP levels (all p for trend and q values of false discovery rate correction < .05). In VBM, elevated serum NT-proBNP levels were correlated with atrophy of the bilateral hippocampi, bilateral amygdalas, bilateral parahippocampal gyri, bilateral entorhinal areas, bilateral fusiform gyri, left middle temporal gyrus, left inferior temporal gyrus, right central operculum, right posterior orbital gyrus, bilateral middle frontal gyri, anterior cingulate gyrus and bilateral medial frontal cortices. In a sensitivity analysis excluding 254 participants with mild cognitive impairment or dementia, serum NT-proBNP levels were correlated with atrophy of the bilateral hippocampi, bilateral amygdalas, bilateral parahippocampal gyri, bilateral fusiform gyri, and left middle frontal gyrus. Our data suggest that elevated serum NT-proBNP levels are associated with gray matter atrophy in brain regions that play an important role in cognitive function.

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  • Autonomic nervous system function assessed by heart rate variability and the presence of symptoms affecting activities of daily living in community-dwelling residents with chronic pain: The Hisayama Study. International journal

    Yuri Nakamura, Mao Shibata, Yukiko Morisaki, Naoki Hirabayashi, Mayu Higashioka, Jun Hata, Masako Hosoi, Nobuyuki Sudo, Ken Yamaura, Toshiharu Ninomiya

    European journal of pain (London, England)   28 ( 5 )   831 - 844   2024.5

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    BACKGROUND: Autonomic nervous system dysfunction has been reported to be associated with impaired activities of daily living (ADL) among patients with chronic pain, but the association has not been fully addressed in general populations. This study cross-sectionally investigated the association between autonomic nervous system function and the presence of subjective symptoms affecting ADL in community-dwelling residents with chronic pain. METHODS: A total of 888 residents with chronic pain, aged 40-79 years, who underwent a health examination in 2017-2018 were included. Based on heart rate variability measured by fingertip pulse wave, the standard deviation of normal-to-normal intervals (SDNN), root mean square of successive RR interval differences (RMSSD), low frequency (LF) power, and high frequency (HF) power were calculated. Symptoms affecting ADL were defined as those scoring ≥1 on the modified Rankin Scale. Odds ratios (ORs) and their 95&#37; confidence intervals (CIs) for symptoms affecting ADL were estimated using a logistic regression analysis. RESULTS: The overall prevalence of symptoms affecting ADL was 39.4&#37;. The ORs for symptoms affecting ADL increased significantly per 1-standard-deviation decrement in log-transformed SDNN (OR 1.23 [95&#37; CI 1.06-1.44]), RMSSD (1.25 [1.08-1.45]), LF power (1.29 [1.11-1.52]), and HF power (1.29 [1.11-1.51]) after adjusting for age, sex, education, hypertension, diabetes, serum total cholesterol level, body mass index, past medical history, current smoking, current drinking, exercise, depressive symptoms, and pain intensity. CONCLUSIONS: Decreased heart rate variability was associated with the presence of symptoms affecting ADL among individuals with chronic pain in a Japanese community. SIGNIFICANCE: Decrease in heart rate variability was associated with the presence of symptoms affecting ADL among individuals with chronic pain in a Japanese community. This article could help scientists understand the significance of autonomic nervous system dysfunction in the pathology of chronic pain. Approaches that target autonomic nervous system dysfunction may be an option to relieve or prevent symptoms affecting ADL for chronic pain sufferers.

    DOI: 10.1002/ejp.2224

  • JCS 2023 Guideline on the Primary Prevention of Coronary Artery Disease

    Fujiyoshi Akira, Kohsaka Shun, Hata Jun, Hara Mitsuhiko, Kai Hisashi, Masuda Daisaku, Miyamatsu Naomi, Nishio Yoshihiko, Ogura Masatsune, Sata Masataka, Sekiguchi Kenji, Takeya Yasushi, Tamura Kouichi, Wakatsuki Akihiko, Yoshida Hiroshi, Fujioka Yoshio, Fukazawa Ryuji, Hamada Osamu, Higashiyama Aya, Kabayama Mai, Kanaoka Koshiro, Kawaguchi Kenjiro, Kosaka Shintaro, Kunimura Ayako, Miyazaki Ayumi, Nii Masaki, Sawano Mitsuaki, Terauchi Masakazu, Yagi Shusuke, Akasaka Takashi, Minamino Tohru, Miura Katsuyuki, Node Koichi, on behalf of the Japanese Circulation Society Joint Working Group

    Circulation Journal   88 ( 5 )   763 - 842   2024.4   ISSN:13469843 eISSN:13474820

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    DOI: 10.1253/circj.cj-23-0285

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  • Serum high-sensitivity C-reactive protein and dementia in a community-dwelling Japanese older population (JPSC-AD) Reviewed International journal

    Tachibana A, Iga JI, Ozaki T, Yoshida T, Yoshino Y, Shimizu H, Mori T, Furuta Y, Shibata M, Ohara T, Hata J, Taki Y, Mikami T, Maeda T, Ono K, Mimura M, Nakashima K, Takebayashi M, Ninomiya T, Ueno SI; JPSC-AD study group

    Sci Rep   14 ( 1 )   7374 - 7374   2024.3   ISSN:2045-2322

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    In recent years, the association between neuroinflammatory markers and dementia, especially Alzheimer's disease (AD), has attracted much attention. However, the evidence for the relationship between serum-hs-CRP and dementia including AD are inconsistent. Therefore, the relationships of serum high-sensitivity CRP (hs-CRP) with dementia including AD and with regions of interest of brain MRI were investigated. A total of 11,957 community residents aged 65 years or older were recruited in eight sites in Japan (JPSC-AD Study). After applying exclusion criteria, 10,085 participants who underwent blood tests and health-related examinations were analyzed. Then, serum hs-CRP levels were classified according to clinical cutoff values, and odds ratios for the presence of all-cause dementia and its subtypes were calculated for each serum hs-CRP level. In addition, the association between serum hs-CRP and brain volume regions of interest was also examined using analysis of covariance with data from 8614 individuals in the same cohort who underwent brain MRI. After multivariable adjustment, the odds ratios (ORs) for all-cause dementia were 1.04 (95% confidence interval [CI] 0.76-1.43), 1.68 (95%CI 1.08-2.61), and 1.51 (95%CI 1.08-2.11) for 1.0-1.9 mg/L, 2.0-2.9 mg/L, and ≥ 3.0 mg/L, respectively, compared to < 1.0 mg/L, and those for AD were 0.72 (95%CI 0.48-1.08), 1.76 (95%CI 1.08-2.89), and 1.61 (95%CI 1.11-2.35), for 1.0-1.9 mg/L, 2.0-2.9 mg/L, and ≥ 3.0 mg/L, respectively, compared to < 1.0 mg/L. Multivariable-adjusted ORs for all-cause dementia and for AD prevalence increased significantly with increasing serum hs-CRP levels (p for trend < 0.001 and p = 0.001, respectively). In addition, the multivariable-adjusted temporal cortex volume/estimated total intracranial volume ratio decreased significantly with increasing serum hs-CRP levels (< 1.0 mg/L 4.28%, 1.0-1.9 mg/L 4.27%, 2.0-2.9 mg/L 4.29%, ≥ 3.0 mg/L 4.21%; p for trend = 0.004). This study's results suggest that elevated serum hs-CRP levels are associated with greater risk of presence of dementia, especially AD, and of temporal cortex atrophy in a community-dwelling Japanese older population.

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  • Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults Reviewed International coauthorship

    NCD Risk Factor Collaboration (NCD-RisC)

    Lancet   403 ( 10431 )   1027 - 1050   2024.3

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    DOI: 10.1016/S0140-6736(23)02750-2

  • Association between Vascular Calcification and Intraplaque Hemorrhage in Coronary Atherosclerosis from Autopsy: The Hisayama Study.

    Toshiaki Nakano, Hiromasa Kitamura, Jun Hata, Kenji Maki, Yoshinao Oda, Takanari Kitazono, Toshiharu Ninomiya

    Journal of atherosclerosis and thrombosis   31 ( 8 )   1225 - 1237   2024.3   ISSN:13403478 eISSN:18803873

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    <p> <b>Aims:</b> Vascular calcification is observed in advanced atherosclerotic lesions. Vascular calcification is considered to increase the risk of intraplaque hemorrhage and subsequent plaque destabilization; however, there is limited pathohistoological evidence of the association between vascular calcification and intraplaque hemorrhage. The aim of this study was to investigate the association between vascular calcification and intraplaque hemorrhage in the coronary arteries.</p><p> <b>Methods:</b> We examined 374 coronary arteries obtained from the autopsy samples of 126 deceased individuals. The vascular calcification levels of each artery were categorized into no calcification and quintiles of calcification area size among the arteries with calcification. Macrophage infiltration and neovascularization were also evaluated. The association of the calcification area, macrophage area, or number of vessels with the presence of intraplaque hemorrhage in the coronary arteries was estimated using a logistic regression analysis.</p><p><b>Results:</b> Calcification lesions were observed in 149 coronary arteries. Arteries in the fourth quintile of calcification area size had a significantly greater likelihood of intraplaque hemorrhage than the arteries without calcification, after adjusting for confounders: odds ratio 13.13 (95% confidence interval: 2.97–58.16). After evaluating the influence of macrophage infiltration, the highest odds ratio of intraplaque hemorrhage was associated with the combination of large macrophage area and moderately sized calicification areas. The odds ratio of intraplaque hemorrhage additively increased with the combination of calcification and the number of vessels.</p><p><b>Conclusions:</b> The present findings suggest that vascular calcification is significantly associated with intraplaque hemorrhage. The association between vascular calcification and intraplaque hemorrhage may decrease above a certain size of the calcification area.</p>

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  • Association between corneal hysteresis and glaucoma in a Japanese population: the Hisayama Study. International journal

    Kohta Fujiwara, Emi Ueda, Jun Hata, Satoko Nakano, Sawako Hashimoto, Shun Nakamura, Yusuke Murakami, Toshiaki Kubota, Takeshi Yoshitomi, Toshiharu Ninomiya, Koh-Hei Sonoda

    The British journal of ophthalmology   2024.3

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    AIMS: To investigate the association between corneal hysteresis and the presence of glaucoma and its subtypes in a general Japanese population. METHODS: We analysed the data of 2338 Japanese community-dwellers aged ≥40 years (1059 men, 1279 women) who underwent an eye examination in 2018 as part of the population-based, cross-sectional Hisayama Study. Participants were divided into quartile levels of corneal hysteresis, which had been measured with an ocular response analyzer. Glaucoma was defined based on the International Society of Geographical and Epidemiological Ophthalmology criteria. We conducted a logistic regression analysis to determine the ORs and their 95&#37; CIs for the presence of outcomes according to the corneal hysteresis quartiles. RESULTS: Glaucoma was diagnosed in 154 participants: primary open-angle glaucoma (POAG), n=115; primary angle-closure glaucoma, n=17; exfoliation glaucoma, n=21 and secondary glaucoma without exfoliation glaucoma, n=1. After adjustment for confounders, the OR for prevalent glaucoma was significantly increased in the participants in the first corneal-hysteresis quartile compared with those in the fourth quartile (OR: 1.80; 95&#37; CI: 1.03 to 3.17). Regarding glaucoma subtypes, the first-quartile participants had significantly greater likelihoods of the presence of POAG (OR: 1.63; 95&#37; CI: 1.02 to 2.61) and exfoliation glaucoma (OR: 6.49; 95&#37; CI: 1.44 to 29.30) compared with those in the third and fourth quartiles after adjustment for potential confounders. CONCLUSIONS: These results demonstrated a significant inverse association between corneal hysteresis and the likelihood of glaucoma, suggesting that the measurement of corneal hysteresis would provide useful information for elucidating the aetiology of glaucoma.

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  • Day-to-day home blood pressure variability and risk of atrial fibrillation in a general Japanese population: the Hisayama Study. International journal

    Akihiro Maezono, Satoko Sakata, Jun Hata, Emi Oishi, Yoshihiko Furuta, Mao Shibata, Tomomi Ide, Takanari Kitazono, Hiroyuki Tsutsui, Toshiharu Ninomiya

    European journal of preventive cardiology   31 ( 9 )   1115 - 1122   2024.2   ISSN:2047-4873 eISSN:2047-4881

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    AIMS: Several prospective studies have reported that higher visit-to-visit blood pressure variability (BPV) is associated with atrial fibrillation (AF). However, no studies have investigated the association between day-to-day BPV assessed by home blood pressure measurement and the development of AF. METHODS: A total of 2,827 community-dwelling Japanese aged ≥40 years without prior AF were followed up for 10 years (2007-2017). Day-to-day home BPV (defined as coefficients of variation [CoV] of home systolic blood pressure [SBP] for 28 days) were categorized into 4 groups according to the quartiles: Q1, ≤4.64%; Q2, 4.65%-5.70%; Q3, 5.71%-7.01%; Q4, ≥7.02%. The hazard ratios for developing AF were estimated using a Cox proportional hazards model. RESULTS: During the follow-up period, 134 participants developed new-onset AF. The crude incidence rates of AF increased significantly with higher CoV levels of home SBP: 2.1, 4.7, 5.3, and 8.8 per 1000 person-years in the first, second, third, and fourth quartiles, respectively (P for trend <0.01). After adjusting for potential confounders, increased CoV levels of home SBP were associated significantly with a higher risk of AF (P for trend =0.02). The participants in the highest quartile of CoV had a 2.18-fold (95% confidence intervals: 1.18-4.04) increased risk of developing AF compared to those in the lowest quartile. CONCLUSIONS: The present findings suggest that increased day-to-day home BPV levels are associated with a higher risk of the development of AF in a general Japanese population.

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  • Longitudinal association of sedentary time with diabetes mellitus and markers of glucose metabolism in middle-aged and older adults: the Hisayama Study Reviewed

    Tsuda S, Honda T, Higashioka M, Hata J, Nakano T, Kitazono T, Ninomiya T

    J Diabetes Investig   15 ( 2 )   245 - 246   2024.2   ISSN:2040-1116 eISSN:2040-1124

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  • 血清リポ多糖結合蛋白濃度とメタボリックシンドローム発症との関連 久山町研究(Serum Lipopolysaccharide-binding Protein Levels and the Incidence of Metabolic Syndrome in a General Japanese Population: the Hisayama Study)

    Tomooka Shoko, Oishi Emi, Asada Masako, Sakata Satoko, Hata Jun, Chen Sanmei, Honda Takanori, Suzuki Kosuke, Watanabe Hiroshi, Murayama Norihito, Wada Naohisa, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Epidemiology   34 ( 1-2 )   1 - 7   2024.2   ISSN:0917-5040

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    <Highlight>●本研究は、血清リポ多糖結合蛋白(LBP)値とメタボリックシンドローム(MetS)発症との関連を検討した最初の前向きコホート研究である。●血清LBP値の上昇に伴いメタボリックシンドロームおよびその構成要素の発症リスクは上昇した。●媒介解析において、HOMA-IRと血清高感度CRPは血清LBPとMetS発症との関連に、部分的に介在していた。●血清LBP値とメタボリックシンドロームの発症リスクの関連はインスリン抵抗性と慢性炎症を介した機序が示唆された。(著者抄録)

  • Serum lipopolysaccharide-binding protein levels and the incidence of metabolic syndrome in a general Japanese population: the Hisayama Study Reviewed

    Tomooka S, Oishi E, Asada M, Sakata S, Hata J, Chen S, Honda T, Suzuki K, Watanabe H, Murayama N, Wada N, Kitazono T, Ninomiya T.

    J Epidemiol   2024.1

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  • Late-life high blood pressure and enlarged perivascular spaces in the putaminal regions of community-dwelling Japanese plder persons. Reviewed International journal

    Tachibana A, Iga JI, Tatewaki Y, Thyreau B, Chen H, Ozaki T, Yoshida T, Yoshino Y, Shimizu H, Mori T, Furuta Y, Shibata M, Ohara T, Hata J, Taki Y, Nakaji S, Maeda T, Ono K, Mimura M, Nakashima K, Takebayashi M, Ninomiya T, Ueno SI; JPSC-AD study group.

    J Geriatr Psychiatry Neurol   37 ( 1 )   61 - 72   2024.1

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    BACKGROUND: Enlarged perivascular spaces (EPVS) of the brain may be involved in dementia, such as Alzheimer's disease and cerebral small vessel disease (CSVD). Hypertension has been reported to be a risk factor for dementia and CSVD, but the association between blood pressure (BP) and perivascular spaces is still unclear. The aim of this study was to determine the association between BP and EPVS volumes and to examine the interactions of relevant factors. METHODS: A total of 9296 community-dwelling subjects aged ≥65 years participated in a brain magnetic resonance imaging and health status screening examination. Perivascular volume was measured using a software package based on deep learning that was developed in-house. The associations between BP and EPVS volumes were examined by analysis of covariance and multiple regression analysis. RESULTS: Mean EPVS volumes increased significantly with rising systolic and diastolic BP levels (P for trend = .003, P for trend<.001, respectively). In addition, mean EPVS volumes increased significantly for every 1-mmHg-increment in systolic and diastolic BPs (both P values <.001). These significant associations were still observed in the sensitivity analysis after excluding subjects with dementia. CONCLUSIONS: The present data suggest that higher systolic and diastolic BP levels are associated with greater EPVS volumes in cognitively normal older people.

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  • Development and validation of a risk pediction model for atherosclerotic cardiovascular disease in Japanese adults: the Hisayama Study Reviewed

    Honda T, Chen S, Hata J, Yoshida D, Hirakawa Y, Furuta Y, Shibata M, Sakata S, Kitazono T, Ninomiya T

    J Atheroscler Thromb   30 ( 12 )   1966 - 1967   2023.12

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  • 地域住民における尿中神経伝達物質と抑うつ症状発症の関連 久山町研究

    柴田 舞欧, 平林 直樹, 細井 雅子, 中村 侑里, 秦 淳, 須藤 信行, 二宮 利治

    日本心療内科学会誌   27 ( 別冊 )   127 - 127   2023.12   ISSN:1342-9558

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  • Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

    Bin Zhou, Kate E. Sheffer, James E. Bennett, Edward W. Gregg, Goodarz Danaei, Rosie K. Singleton, Jonathan E. Shaw, Anu Mishra, Victor P. F. Lhoste, Rodrigo M. Carrillo-Larco, Andre P. Kengne, Nowell H. Phelps, Rachel A. Heap, Archie W. Rayner, Gretchen A. Stevens, Chris J. Paciorek, Leanne M. Riley, Melanie J. Cowan, Stefan Savin, Stephen Vander Hoorn, Yuan Lu, Meda E. Pavkov, Giuseppina Imperatore, Carlos A. Aguilar-Salinas, Noor Ani Ahmad, Ranjit Mohan Anjana, Kairat Davletov, Farshad Farzadfar, Clicerio González-Villalpando, Young-Ho Khang, Hyeon Chang Kim, Tiina Laatikainen, Avula Laxmaiah, Jean Claude N. Mbanya, K. M. Venkat Narayan, Ambady Ramachandran, Alisha N. Wade, Tomasz Zdrojewski, Mohsen Abbasi-Kangevari, Hanan F. Abdul Rahim, Niveen M. Abu-Rmeileh, Shalkar Adambekov, Robert J. Adams, Wichai Aekplakorn, Imelda A. Agdeppa, Javad Aghazadeh-Attari, Charles Agyemang, Ali Ahmadi, Naser Ahmadi, Nastaran Ahmadi, Soheir H. Ahmed, Kamel Ajlouni, Halima Al-Hinai, Badreya Al-Lahou, Jawad A. Al-Lawati, Deena Al Asfoor, Nawal M. Al Qaoud, Monira Alarouj, Fadia AlBuhairan, Shahla AlDhukair, Maryam A. Aldwairji, Mohamed M. Ali, Farbod Alinezhad, Abdullah Alkandari, Husam F. Alomirah, Eman Aly, Deepak N. Amarapurkar, Lars Bo Andersen, Sigmund A. Anderssen, Dolores S. Andrade, Alireza Ansari-Moghaddam, Hajer Aounallah-Skhiri, Tahir Aris, Nimmathota Arlappa, Krishna K. Aryal, Felix K. Assah, Batyrbek Assembekov, Juha Auvinen, Mária Avdičová, Kishwar Azad, Mohsen Azimi-Nezhad, Fereidoun Azizi, Flora Bacopoulou, Nagalla Balakrishna, Mohamed Bamoshmoosh, Maciej Banach, Piotr Bandosz, José R. Banegas, Carlo M. Barbagallo, Alberto Barceló, Maja Baretić, Lena Barrera, Abdul Basit, Anwar M. Batieha, Aline P. Batista, Louise A. Baur, Antonisamy Belavendra, Habiba Ben Romdhane, Mikhail Benet, Salim Berkinbayev, Antonio Bernabe-Ortiz, Ximena Berrios Carrasola, Heloísa Bettiol, Augustin F. Beybey, Santosh K. Bhargava, Elysée Claude Bika Lele, Mukharram M. Bikbov, Bihungum Bista, Peter Bjerregaard, Espen Bjertness, Marius B. Bjertness, Cecilia Björkelund, Katia V. Bloch, Anneke Blokstra, Simona Bo, Martin Bobak, Jose G. Boggia, Marialaura Bonaccio, Alice Bonilla-Vargas, Herman Borghs, Pascal Bovet, Imperia Brajkovich, Hermann Brenner, Lizzy M. Brewster, Garry R. Brian, Yajaira Briceño, Miguel Brito, Anna Bugge, Frank Buntinx, Antonio Cabrera de León, Roberta B. Caixeta, Günay Can, Ana Paula C. Cândido, Mario V. Capanzana, Naděžda Čapková, Eduardo Capuano, Rocco Capuano, Vincenzo Capuano, Viviane C. Cardoso, Axel C. Carlsson, Felipe F. Casanueva, Laura Censi, Marvin Cervantes‐Loaiza, Parinya Chamnan, Snehalatha Chamukuttan, Queenie Chan, Fadi J. Charchar, Nish Chaturvedi, Huashuai Chen, Bahman Cheraghian, María-Dolores Chirlaque, Jerzy Chudek, Renata Cifkova, Massimo Cirillo, Frank Claessens, Emmanuel Cohen, Hans Concin, Cyrus Cooper, Simona Costanzo, Chris Cowell, Ana B. Crujeiras, Juan J. Cruz, Felipe V. Cureau, Sarah Cuschieri, Graziella D’Arrigo, Eleonora d’Orsi, Jean Dallongeville, Albertino Damasceno, Saeed Dastgiri, Amalia De Curtis, Giovanni de Gaetano, Stefaan De Henauw, Mohan Deepa, Vincent DeGennaro, Stefaan Demarest, Elaine Dennison, Valérie Deschamps, Meghnath Dhimal, Zivka Dika, Shirin Djalalinia, Chiara Donfrancesco, Guanghui Dong, Maria Dorobantu, Marcus Dörr, Nico Dragano, Wojciech Drygas, Yong Du, Charmaine A. Duante, Priscilla Duboz, Anar Dushpanova, Elzbieta Dziankowska-Zaborszczyk, Narges Ebrahimi, Ricky Eddie, Ebrahim Eftekhar, Vasiliki Efthymiou, Eruke E. Egbagbe, Sareh Eghtesad, Mohammad El-Khateeb, Jalila El Ati, Denise Eldemire-Shearer, Roberto Elosua, Ofem Enang, Rajiv T. Erasmus, Raimund Erbel, Cihangir Erem, Gul Ergor, Louise Eriksen, Johan G. Eriksson, Ali Esmaeili, Roger G. Evans, Ildar Fakhradiyev, Caroline H. Fall, Elnaz Faramarzi, Mojtaba Farjam, Yosef Farzi, Mohammad Reza Fattahi, Asher Fawwad, Francisco J. Felix-Redondo, Trevor S. Ferguson, Daniel Fernández-Bergés, Marika Ferrari, Catterina Ferreccio, Haroldo S. Ferreira, Eldridge Ferrer, Edith J. M. Feskens, David Flood, Maria Forsner, Sandrine Fosse, Edward F. Fottrell, Heba M. Fouad, Damian K. Francis, Guillermo Frontera, Takuro Furusawa, Zbigniew Gaciong, Sarah P. Garnett, Magda Gasull, Andrea Gazzinelli, Ulrike Gehring, Ebrahim Ghaderi, Seyyed-Hadi Ghamari, Ali Ghanbari, Erfan Ghasemi, Oana-Florentina Gheorghe-Fronea, Anup Ghimire, Alessandro Gialluisi, Simona Giampaoli, Francesco Gianfagna, Tiffany K. Gill, Glen Gironella, Aleksander Giwercman, David Goltzman, Aleksandra Gomula, Helen Gonçalves, Mauer Gonçalves, David A. Gonzalez-Chica, Marcela Gonzalez-Gross, Juan P. González-Rivas, María-Elena González-Villalpando, Angel R. Gonzalez, Frederic Gottrand, Dušan Grafnetter, Tomasz Grodzicki, Anders Grøntved, Ramiro Guerrero, Unjali P. Gujral, Rajeev Gupta, Laura Gutierrez, Xinyi Gwee, Rosa Haghshenas, Hamid Hakimi, Ian R. Hambleton, Behrooz Hamzeh, Willem A. Hanekom, Dominique Hange, Sari Hantunen, Jie Hao, Rachakulla Hari Kumar, Javad Harooni, Seyed Mohammad Hashemi-Shahri, Jun Hata, Christin Heidemann, Rafael dos Santos Henrique, Sauli Herrala, Karl-Heinz Herzig, Ramin Heshmat, Sai Yin Ho, Michelle Holdsworth, Reza Homayounfar, Wilma M. Hopman, Andrea R. V. R. Horimoto, Claudia Hormiga, Bernardo L. Horta, Leila Houti, Christina Howitt, Thein Thein Htay, Aung Soe Htet, Maung Maung Than Htike, José María Huerta, Ilpo Tapani Huhtaniemi, Martijn Huisman, Abdullatif Husseini, Inge Huybrechts, Licia Iacoviello, Ellina M. Iakupova, Anna G. Iannone, Norazizah Ibrahim Wong, Chinwuba Ijoma, Vilma E. Irazola, Takafumi Ishida, Godsent C. Isiguzo, Sheikh Mohammed Shariful Islam, Duygu Islek, Till Ittermann, Masanori Iwasaki, Tuija Jääskeläinen, Jeremy M. Jacobs, Hashem Y. Jaddou, Michel Jadoul, Bakary Jallow, Kenneth James, Kazi M. Jamil, Edward Janus, Marjo-Riitta Jarvelin, Grazyna Jasienska, Ana Jelaković, Bojan Jelaković, Garry Jennings, Anjani Kumar Jha, Ramon O. Jimenez, Karl-Heinz Jöckel, Jari J. Jokelainen, Jost B. Jonas, Pradeep Joshi, Josipa Josipović, Farahnaz Joukar, Jacek Jóźwiak, Anthony Kafatos, Eero O. Kajantie, Zhanna Kalmatayeva, Khem B. Karki, Marzieh Katibeh, Jussi Kauhanen, Gyulli M. Kazakbaeva, François F. Kaze, Calvin Ke, Sirkka Keinänen-Kiukaanniemi, Roya Kelishadi, Maryam Keramati, Mathilde Kersting, Yousef Saleh Khader, Arsalan Khaledifar, Davood Khalili, Bahareh Kheiri, Motahareh Kheradmand, Alireza Khosravi, Ursula Kiechl-Kohlendorfer, Sophia J. Kiechl, Stefan Kiechl, Andrew Kingston, Heidi Klakk, Jana Klanova, Michael Knoflach, Patrick Kolsteren, Jürgen König, Raija Korpelainen, Paul Korrovits, Jelena Kos, Seppo Koskinen, Sudhir Kowlessur, Slawomir Koziel, Susi Kriemler, Peter Lund Kristensen, Daan Kromhout, Ruzena Kubinova, Urho M. Kujala, Mukhtar Kulimbet, Pawel Kurjata, Catherine Kyobutungi, Quang Ngoc La, Demetre Labadarios, Carl Lachat, Youcef Laid, Lachmie Lall, Tiina Lankila, Vera Lanska, Georg Lappas, Bagher Larijani, Tint Swe Latt, Martino Laurenzi, Nils Lehmann, Terho Lehtimäki, Daniel Lemogoum, Gabriel M. Leung, Yanping Li, M. Fernanda Lima-Costa, Hsien-Ho Lin, Lars Lind, Lauren Lissner, Xiaotian Liu, Esther Lopez-Garcia, Tania Lopez, José Eugenio Lozano, Dalia Luksiene, Annamari Lundqvist, Nuno Lunet, Michala Lustigová, George L. L. Machado-Coelho, Aristides M. Machado-Rodrigues, Enguerran Macia, Luisa M. Macieira, Ahmed A. Madar, Gladys E. Maestre, Stefania Maggi, Dianna J. Magliano, Emmanuella Magriplis, Gowri Mahasampath, Bernard Maire, Marcia Makdisse, Mohammad-Reza Malekpour, Fatemeh Malekzadeh, Reza Malekzadeh, Kodavanti Mallikharjuna Rao, Sofia Malyutina, Lynell V. Maniego, Yannis Manios, Masimango Imani Mannix, Fariborz Mansour-Ghanaei, Enzo Manzato, Paula Margozzini, Joany Mariño, Larissa Pruner Marques, Reynaldo Martorell, Luis P. Mascarenhas, Masoud Masinaei, Ellisiv B. Mathiesen, Tandi E. Matsha, Anselmo J. Mc Donald Posso, Shelly R. McFarlane, Stephen T. McGarvey, Sounnia Mediene Benchekor, Kirsten Mehlig, Amir Houshang Mehrparvar, Jesus D. Melgarejo, Fabián Méndez, Ana Maria B. Menezes, Alibek Mereke, Indrapal I. Meshram, Diane T. Meto, Cláudia S. Minderico, G. K. Mini, Juan Francisco Miquel, J. Jaime Miranda, Mohammad Reza Mirjalili, Pietro A. Modesti, Sahar Saeedi Moghaddam, Mostafa K. Mohamed, Kazem Mohammad, Mohammad Reza Mohammadi, Zahra Mohammadi, Noushin Mohammadifard, Reza Mohammadpourhodki, Viswanathan Mohan, Muhammad Fadhli Mohd Yusoff, Iraj Mohebbi, Niels C. Møller, Dénes Molnár, Amirabbas Momenan, Charles K. Mondo, Roger A. Montenegro Mendoza, Eric Monterrubio-Flores, Mahmood Moosazadeh, Farhad Moradpour, Alain Morejon, Luis A. Moreno, Karen Morgan, Suzanne N. Morin, Alireza Moslem, Mildrey Mosquera, Malgorzata Mossakowska, Aya Mostafa, Seyed-Ali Mostafavi, Mohammad Esmaeel Motlagh, Jorge Motta, Kelias P. Msyamboza, Thet Thet Mu, Maria L. Muiesan, Jaakko Mursu, Kamarul Imran Musa, Norlaila Mustafa, Muel Telo M. C. Muyer, Iraj Nabipour, Gabriele Nagel, Balkish M. Naidu, Farid Najafi, Jana Námešná, Vinay B. Nangia, Take Naseri, Nareemarn Neelapaichit, Azim Nejatizadeh, Ilona Nenko, Flavio Nervi, Tze Pin Ng, Chung T. Nguyen, Quang Ngoc Nguyen, Michael Y. Ni, Peng Nie, Ramfis E. Nieto-Martínez, Toshiharu Ninomiya, Marianna Noale, Oscar A. Noboa, Davide Noto, Mohannad Al Nsour, Irfan Nuhoğlu, Terence W. O’Neill, Augustine N. Odili, Kyungwon Oh, Ryutaro Ohtsuka, Mohd Azahadi Omar, Altan Onat, Sok King Ong, Obinna Onodugo, Pedro Ordunez, Rui Ornelas, Pedro J. Ortiz, Clive Osmond, Afshin Ostovar, Johanna A. Otero, Charlotte B. Ottendahl, Akaninyene Otu, Ellis Owusu-Dabo, Luigi Palmieri, Wen-Harn Pan, Songhomitra Panda-Jonas, Francesco Panza, Mariela Paoli, Suyeon Park, Mahboubeh Parsaeian, Nikhil D. Patel, Raimund Pechlaner, Ivan Pećin, João M. Pedro, Sergio Viana Peixoto, Markku Peltonen, Alexandre C. Pereira, Thaliane Mayara Pessôa dos Prazeres, Niloofar Peykari, Modou Cheyassin Phall, Son Thai Pham, Hiep Hoang Phan, Rafael N. Pichardo, Hynek Pikhart, Aida Pilav, Pavel Piler, Freda Pitakaka, Aleksandra Piwonska, Andreia N. Pizarro, Pedro Plans-Rubió, Silvia Plata, Miquel Porta, Anil Poudyal, Farhad Pourfarzi, Akram Pourshams, Hossein Poustchi, Rajendra Pradeepa, Rui Providencia, Jardena J. Puder, Solie Puhakka, Margus Punab, Mostafa Qorbani, Hedley K. Quintana, Tran Quoc Bao, Salar Rahimikazerooni, Olli Raitakari, Manuel Ramirez-Zea, Jacqueline Ramke, Rafel Ramos, Lekhraj Rampal, Sanjay Rampal, Daniel A. Rangel Reina, Mohammad-Mahdi Rashidi, Josep Redon, Jane D. P. Renner, Cézane P. Reuter, Luis Revilla, Negar Rezaei, Abbas Rezaianzadeh, Fernando Rigo, Reina G. Roa, Louise Robinson, Fernando Rodríguez-Artalejo, María del Cristo Rodriguez-Perez, Laura A. Rodríguez-Villamizar, Andrea Y. Rodríguez, Ulla Roggenbuck, Peter Rohloff, Elisabetta L. Romeo, Annika Rosengren, Adolfo Rubinstein, Petra Rust, Marcin Rutkowski, Hamideh Sabbaghi, Harshpal S. Sachdev, Alireza Sadjadi, Ali Reza Safarpour, Sare Safi, Saeid Safiri, Mohammad Hossien Saghi, Olfa Saidi, Nader Saki, Sanja Šalaj, Benoit Salanave, Jukka T. Salonen, Massimo Salvetti, Jose Sánchez-Abanto, Diana A. Santos, Lèlita C. Santos, Maria Paula Santos, Tamara R. Santos, Jouko L. Saramies, Luis B. Sardinha, Nizal Sarrafzadegan, Kai-Uwe Saum, Mariana Sbaraini, Marcia Scazufca, Beatriz D. Schaan, Christa Scheidt-Nave, Sabine Schipf, Carsten O. Schmidt, Ben Schöttker, Sara Schramm, Sylvain Sebert, Moslem Sedaghattalab, Aye Aye Sein, Sadaf G. Sepanlou, Ronel Sewpaul, Teresa Shamah-Levy, Seyed Morteza Shamshirgaran, Maryam Sharafkhah, Sanjib K. Sharma, Almaz Sharman, Amaneh Shayanrad, Ali Akbar Shayesteh, Hana Shimizu-Furusawa, Rahman Shiri, Namuna Shrestha, Khairil Si-Ramlee, Diego Augusto Santos Silva, Mary Simon, Judith Simons, Leon A. Simons, Michael Sjöström, Jolanta Slowikowska-Hilczer, Przemysław Slusarczyk, Liam Smeeth, Eugène Sobngwi, Stefan Söderberg, Agustinus Soemantri, Reecha Sofat, Vincenzo Solfrizzi, Mohammad Hossein Somi, Aïcha Soumaré, Alfonso Sousa-Poza, Karen Sparrenberger, Jan A. Staessen, Bill Stavreski, Jostein Steene-Johannessen, Peter Stehle, Aryeh D. Stein, Jochanan Stessman, Jakub Stokwiszewski, Karien Stronks, Milton F. Suarez-Ortegón, Phalakorn Suebsamran, Johan Sundström, Paibul Suriyawongpaisal, René Charles Sylva, Moyses Szklo, Abdonas Tamosiunas, Mohammed Rasoul Tarawneh, Carolina B. Tarqui-Mamani, Anne Taylor, Julie Taylor, Tania Tello, K. R. Thankappan, Holger Theobald, Xenophon Theodoridis, Nihal Thomas, Amanda G. Thrift, Erik J. Timmermans, Dwi Hapsari Tjandrarini, Hanna K. Tolonen, Janne S. Tolstrup, Maciej Tomaszewski, Murat Topbas, Laura Torres-Collado, Pierre Traissac, Areti Triantafyllou, John Tuitele, Azaliia M. Tuliakova, Marshall K. Tulloch-Reid, Tomi-Pekka Tuomainen, Evangelia Tzala, Christophe Tzourio, Peter Ueda, Eunice Ugel, Flora A. M. Ukoli, Hanno Ulmer, Hannu M. T. Uusitalo, Gonzalo Valdivia, Bert-Jan van den Born, Johan Van der Heyden, Hoang Van Minh, Lenie van Rossem, Natasja M. Van Schoor, Irene G. M. van Valkengoed, Elisabeth M. van Zutphen, Dirk Vanderschueren, Diego Vanuzzo, Senthil K. Vasan, Tomas Vega, Gustavo Velasquez-Melendez, Roosmarijn Verstraeten, Lucie Viet, Salvador Villalpando, Jesus Vioque, Jyrki K. Virtanen, Bharathi Viswanathan, Ari Voutilainen, Wan Mohamad Wan Bebakar, Wan Nazaimoon Wan Mohamud, Chongjian Wang, Ningli Wang, Qian Wang, Ya Xing Wang, Ying-Wei Wang, S. Goya Wannamethee, Karen Webster-Kerr, Niels Wedderkopp, Wenbin Wei, Leo D. Westbury, Peter H. Whincup, Kurt Widhalm, Indah S. Widyahening, Andrzej Więcek, Rainford J. Wilks, Johann Willeit, Peter Willeit, Tom Wilsgaard, Bogdan Wojtyniak, Andrew Wong, Emily B. Wong, Mark Woodward, Frederick C. Wu, Haiquan Xu, Liang Xu, Nor Azwany Yaacob, Li Yan, Weili Yan, Moein Yoosefi, Akihiro Yoshihara, Novie O. Younger-Coleman, Yu-Ling Yu, Yunjiang Yu, Ahmad Faudzi Yusoff, Ahmad A. Zainuddin, Farhad Zamani, Sabina Zambon, Antonis Zampelas, Ko Ko Zaw, Tajana Zeljkovic Vrkic, Yi Zeng, Zhen-Yu Zhang, Bekbolat Zholdin, Paul Zimmet, Emanuel Zitt, Nada Zoghlami, Julio Zuñiga Cisneros, Majid Ezzati

    Nature Medicine   2023.11

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    Abstract

    Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening, had elevated FPG, HbA1c or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardized proportion of diabetes that was previously undiagnosed and detected in survey screening ranged from 30&#37; in the high-income western region to 66&#37; in south Asia. Among those with screen-detected diabetes with either test, the age-standardized proportion who had elevated levels of both FPG and HbA1c was 29–39&#37; across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c was more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global shortfall in diabetes diagnosis and surveillance.

    DOI: 10.1038/s41591-023-02610-2

  • 地域在住の日本人高齢者において性別と年齢は歩行速度と軽度認知障害の関連に影響を及ぼす Japan Prospective Studies Collaboration for Ageing and Dementia(JPSC-AD)(Gender and age influence the association between gait speed and mild cognitive impairment in community-dwelling Japanese older adults: from the Japan Prospective Studies Collaboration for Ageing and Dementia(JPSC-AD))

    Bun Shogyoku, Suzuki Kouta, Niimura Hidehito, Shikimoto Ryo, Kida Hisashi, Shibata Mao, Honda Takanori, Ohara Tomoyuki, Hata Jun, Nakaji Shigeyuki, Maeda Tetsuya, Ono Kenjiro, Nakashima Kenji, Iga Jun-ichi, Takebayashi Minoru, Ninomiya Toshiharu, Mimura Masaru

    Psychogeriatrics   23 ( 6 )   918 - 929   2023.11   ISSN:1346-3500

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    日本人高齢者における軽度認知障害(MCI)と歩行速度の関連について検討した。2016~2018年にJPSC-ADに参加した65歳以上の日本人8233人(男性3540人、女性4693人、平均72.8±6.0歳)を対象とした。性別及び年齢グループにより層別化した後、参加者の歩行速度を5グループに分けた。その結果、歩行速度の低下はMCIのオッズ上昇と関連し、性別及び年齢により変化していた。また、歩行速度はMCIのスクリーニングツールとして有用であることが示された。

  • Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation Reviewed International coauthorship

    Emerging Risk Factors Collaboration

    Lancet Diabetes Endocrinol   11 ( 10 )   731 - 742   2023.10

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    DOI: 10.1016/S2213-8587(23)00223-1

  • 血漿認知症バイオマーカーと認知症発症の関係 地域前向きコホート研究の成績より

    小原 知之, 秦 淳, 徳田 隆彦, 本田 貴紀, 柴田 舞欧, 中路 重之, 前田 哲也, 小野 賢二郎, 三村 將, 中島 健二, 伊賀 淳一, 竹林 実, 二宮 利治

    老年精神医学雑誌   34 ( 増刊II )   194 - 194   2023.10   ISSN:0915-6305

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    Language:Japanese   Publisher:(株)ワールドプランニング  

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  • Association Between Frequency of Social Contact and Brain Atrophy in Community-Dwelling Older People Without Dementia

    Hirabayashi, N; Honda, T; Hata, J; Furuta, Y; Shibata, M; Ohara, T; Tatewaki, Y; Taki, Y; Nakaji, S; Maeda, T; Ono, K; Mimura, M; Nakashima, K; Iga, JI; Takebayashi, M; Ninomiya, T

    NEUROLOGY   101 ( 11 )   E1108 - E1117   2023.9   ISSN:0028-3878 eISSN:1526-632X

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    Background and ObjectivesEpidemiologic evidence has shown that social isolation, a low frequency of social contact with others, is associated with the risk of dementia and late-life depressive symptoms. Therefore, we hypothesized that low frequency of social contact may be involved in brain atrophy, and depressive symptoms may play some role in this relationship. We aimed to evaluate the association between low frequency of social contact and the volumes of various brain regions and to assess the extent to which depressive symptoms mediate these relationships from a large population-based multisite cohort study.MethodsDementia-free community-dwelling Japanese aged 65 years or older underwent brain MRI scans and a comprehensive health examination. Frequency of contact with noncohabiting relatives and friends was determined by asking a single question with 4 categories: everyday, several times a week, several times a month, and seldom. Total and regional brain volumes, intracranial volume (ICV), and white matter lesion volume were estimated using FreeSurfer software. The associations between frequency of social contact and brain volumes per ICV were examined using analyses of covariance. Mediation analyses were conducted to calculate the proportion of the associations explained by depressive symptoms.ResultsWe included 8,896 participants. The multivariable-adjusted mean of the total brain volume in the group with the lowest frequency of social contact was significantly lower compared with that in the group with the highest frequency of social contact (67.3% vs 67.8%), with a significant increasing trend across the groups (p value for trend <0.001). The white matter lesion volume increased significantly with lower frequency of social contact (0.30% in the lowest frequency group vs 0.26% in the highest frequency group, p value for trend <0.001). Lower frequency of social contact was associated with smaller volumes in the temporal lobe, occipital lobe, cingulum, hippocampus, and amygdala (all q values of false discovery rate correction <0.05). The relationships seemed to be partly mediated by depressive symptoms, which accounted for 15%-29% of the observed associations.DiscussionLower frequency of social contact was associated with decreased total and cognitive function-related regional brain volumes. In addition, depressive symptoms partially explained the association in community-dwelling older people without dementia in Japan.

    DOI: 10.1212/WNL.0000000000207602

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    Scopus

    PubMed

  • 日本人一般集団における血圧の日間変動と慢性腎臓病発症リスク

    佐々木 峻也, 坂田 智子, 大石 絵美, 秦 淳, 坪井 伸夫, 北園 孝成, 横尾 隆, 二宮 利治

    日本高血圧学会総会プログラム・抄録集   45回   212 - 212   2023.9

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  • Gender and age influence the association between gait speed and mild cognitive impairment in community‐dwelling Japanese older adults: from the Japan Prospective Studies Collaboration for Ageing and Dementia (JPSC‐AD) Reviewed International journal

    Shogyoku Bun, Kouta Suzuki, Hidehito Niimura, Ryo Shikimoto, Hisashi Kida, Mao Shibata, Takanori Honda, Tomoyuki Ohara, Jun Hata, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Kenji Nakashima, Jun‐ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya, Masaru Mimura

    Psychogeriatrics   2023.8

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    Background

    Studies have shown that decreased gait speed is associated with impaired cognitive function. However, whether this association is equivalent across ages or genders in the older population remains unclear. Thus, we examined the association between mild cognitive impairment (MCI) and gait speed emphasising the influence of age and gender.

    Methods

    Overall, 8233 Japanese participants aged ≥65 years were enrolled in this cross‐sectional study between 2016 and 2018. After stratification by gender and age group, the participants' gait speeds were divided into quintiles, and the difference in MCI prevalence at each gait speed quintile was calculated. Logistic regression analyses were performed to assess the odds of MCI for each quintile and to assess the influence of age and gender.

    Results

    Males had a consistently higher prevalence of MCI than females. The odds of MCI were increased as gait speed decreased. Logistic regression analyses revealed that in the multivariable‐adjusted model 2, the odds ratios (95% confidence interval; CI) for MCI were 2.02 (1.47–2.76) for females and 1.75 (1.29–2.38) for males in the slowest gait speed quintiles compared to the fastest quintile. In the stratified analyses, only males showed an age‐dependent increase in the associations between gait speed and MCI, while females exhibited comparable associations across age groups.

    Conclusions

    Reduced gait speed was associated with increased odds of MCI, and this association may vary according to gender and age. Therefore, gait speed could serve as a valuable screening tool for MCI, with gender‐ and age‐dependent clinical implications.

    DOI: 10.1111/psyg.13013

  • Skin carotenoid levels and metabolic syndrome in a general Japanese population: the Hisayama Study

    Kimura, Y; Hata, J; Honda, T; Shibata, M; Sakata, S; Furuta, Y; Ninomiya, T

    ANNALS OF NUTRITION AND METABOLISM   79   903 - 903   2023.8   ISSN:0250-6807 eISSN:1421-9697

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  • Association Between Frequency of Social Contact and Brain Atrophy in Community-Dwelling Older People Without Dementia: The JPSC-AD Study. International journal

    Naoki Hirabayashi, Takanori Honda, Jun Hata, Yoshihiko Furuta, Mao Shibata, Tomoyuki Ohara, Yasuko Tatewaki, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya

    Neurology   2023.7   eISSN:1526-632X

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    BACKGROUND AND OBJECTIVES: Epidemiological evidence has shown that social isolation, a low frequency of social contact with others, is associated with the risk of dementia and late-life depressive symptoms. Therefore, we hypothesized that low frequency of social contact may be involved in brain atrophy, and depressive symptoms may play some role in this relationship. We aimed to evaluate the association between low frequency of social contact and the volumes of various brain regions and to assess the extent to which depressive symptoms mediate these relationships from a large population-based multisite cohort study. METHODS: Dementia-free community-dwelling Japanese aged ≥65 years underwent brain MRI scans and a comprehensive health examination. Frequency of contact with non-cohabiting relatives and friends was determined by asking a single question with four categories: everyday, several times a week, several times a month, and seldom. Total and regional brain volumes, intracranial volume (ICV) and white matter lesions volume were estimated using FreeSurfer software. The associations between frequency of social contact and brain volumes per ICV were examined using analyses of covariance. Mediation analyses were conducted to calculate the proportion of the associations explained by depressive symptoms. RESULTS: We included 8,896 participants. The multivariable-adjusted mean of the total brain volume in the group with the lowest frequency of social contact was significantly lower compared to that in the group with the highest frequency (67.3% vs 67.8%), with a significant increasing trend across the groups (p value for trend <0.001). The white matter lesions volume increased significantly with lower frequency of social contact (0.30% in the lowest frequency vs 0.26% in the highest frequency group, p value for trend <0.001). Lower frequency of social contact was associated with smaller volumes in the temporal lobe, occipital lobe, cingulum, hippocampus, and amygdala (all q value of FDR correction <0.05). The relationships appeared to be partly mediated by depressive symptoms, which accounted for 15% to 29% of the observed associations. DISCUSSION: Lower frequency of social contact was associated with decreased total and cognitive function-related regional brain volumes. In addition, depressive symptoms partially explained the association in community-dwelling older people without dementia in Japan.

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  • Epidemiology of Stroke in a General Japanese Population: The Hisayama Study

    Hata Jun, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   30 ( 7 )   710 - 719   2023.7   ISSN:13403478 eISSN:18803873

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    <p>The Hisayama Study is an ongoing epidemiological study of stroke, coronary artery disease (CAD), and other noncommunicable diseases in a general Japanese population established in 1961. According to the longitudinal data from the Hisayama Study, average levels of systolic blood pressure among hypertensive individuals have decreased with time since 1961. In contrast, the prevalence of metabolic risk factors such as obesity, hypercholesterolemia, and glucose intolerance has increased with time. The incidence rates of ischemic stroke in this population have declined significantly as a result of improvement in hypertension management, but the proportion of atherothrombotic brain infarction (ATBI) and embolic stroke among the total ischemic stroke cases have increased probably due to the increased prevalence of metabolic risk factors and the increased number of patients with atrial fibrillation (AF) with super-aging population. Therefore, a strategy to reduce the risks of ATBI and embolic stroke by comprehensive management of their risk factors is necessary.</p><p>In this review, we first show the secular trends in the incidence of stroke and the prevalence of its risk factors using the data from the Hisayama Study. Then, the studies for the association of traditional risk factors with stroke development in the Hisayama Study are introduced. Finally, we developed risk prediction models to estimate the absolute risk of atherosclerotic cardiovascular disease (ASCVD; including ATBI and CAD) and AF, that may be used for the stratification of future risk of ATBI and AF-related stroke in clinical practice or health examination.</p>

    DOI: 10.5551/jat.rv22004

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  • Association between frequency of social contact and brain atrophy in community-dwelling older people without dementia: the JPSC-AD Study. Reviewed International journal

    Naoki Hirabayashi, Takanori Honda, Jun Hata, Yoshihiko Furuta, Mao Shibata, Tomoyuki Ohara, Yasuko Tatewaki, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya

    Neurology   2023.7

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    BACKGROUND AND OBJECTIVES: Epidemiological evidence has shown that social isolation, a low frequency of social contact with others, is associated with the risk of dementia and late-life depressive symptoms. Therefore, we hypothesized that low frequency of social contact may be involved in brain atrophy, and depressive symptoms may play some role in this relationship. We aimed to evaluate the association between low frequency of social contact and the volumes of various brain regions and to assess the extent to which depressive symptoms mediate these relationships from a large population-based multisite cohort study. METHODS: Dementia-free community-dwelling Japanese aged ≥65 years underwent brain MRI scans and a comprehensive health examination. Frequency of contact with non-cohabiting relatives and friends was determined by asking a single question with four categories: everyday, several times a week, several times a month, and seldom. Total and regional brain volumes, intracranial volume (ICV) and white matter lesions volume were estimated using FreeSurfer software. The associations between frequency of social contact and brain volumes per ICV were examined using analyses of covariance. Mediation analyses were conducted to calculate the proportion of the associations explained by depressive symptoms. RESULTS: We included 8,896 participants. The multivariable-adjusted mean of the total brain volume in the group with the lowest frequency of social contact was significantly lower compared to that in the group with the highest frequency (67.3% vs 67.8%), with a significant increasing trend across the groups (p value for trend <0.001). The white matter lesions volume increased significantly with lower frequency of social contact (0.30% in the lowest frequency vs 0.26% in the highest frequency group, p value for trend <0.001). Lower frequency of social contact was associated with smaller volumes in the temporal lobe, occipital lobe, cingulum, hippocampus, and amygdala (all q value of FDR correction <0.05). The relationships appeared to be partly mediated by depressive symptoms, which accounted for 15% to 29% of the observed associations. DISCUSSION: Lower frequency of social contact was associated with decreased total and cognitive function-related regional brain volumes. In addition, depressive symptoms partially explained the association in community-dwelling older people without dementia in Japan.

  • Changes in the eicosapentaenoic acid to arachidonic acid ratio in serum over 10 years in a Japanese community: the Hisayama Study Reviewed

    Honda T, Chen S, Hata J, Shibata M, Furuta Y, Oishi E, Sakata S, Kitazono T, Ninomiya T.

    J Atheroscler Thromb   2023.6

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    DOI: 10.5551/jat.63727

  • Serum Mac-2 binding protein glycosylation isomer concentrations are associated with incidence of type 2 diabetes Reviewed International journal

    Higashioka M, Hirakawa Y, Hata J, Honda T, Sakata S, Shibata M, Kitazono T, Osawa H, Ninomiya T.

    J Clin Endocrinol Metab   2023.6

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    DOI: 10.1210/clinem/dgad011

  • Association between choroidal thickness and myopic maculopathy in a Japanese population: the Hisayama Study Reviewed International journal

    Emi Ueda, Miho Yasuda, Kohta Fujiwara, Sawako Hashimoto, Takanori Honda, Shun Nakamura, Jun Hata, Toshiharu Ninomiya, Koh-Hei Sonoda

    Ophthalmology Science   100350 - 100350   2023.6

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    DOI: 10.1016/j.xops.2023.100350

  • Association of white matter lesions and brain atrophy with the development of dementia in a community: the Hisayama Study Reviewed

    Nakazawa T, Ohara T, Hirabayashi N, Furuta Y, Hata J, Shibata M, Honda T, Kitazono T, Nakao T, Ninomiya T.

    Psychiatry Clin Neurosci   2023.6

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    DOI: 10.1111/pcn.13533

  • 地域における白質病変及び脳萎縮と認知症の発症の関連 久山町研究(Association of white matter lesions and brain atrophy with the development of dementia in a community: the Hisayama Study)

    Nakazawa Taro, Ohara Tomoyuki, Hirabayashi Naoki, Furuta Yoshihiko, Hata Jun, Shibata Mao, Honda Takanori, Kitazono Takanari, Nakao Tomohiro, Ninomiya Toshiharu

    Psychiatry and Clinical Neurosciences   77 ( 5-6 )   330 - 337   2023.6   ISSN:1323-1316

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    高齢者集団における白質病変容積(WMLV)及び脳萎縮と認知症リスクの関係について検討した。福岡県久山町の認知症がない65歳以上の住民のうち、脳MRIを実施した1158人(男性512人、女性646人、平均73.6±6.2歳)を対象とした。WMLVをLesion Segmentation Toolboxを用いてセグメント化し、全脳容積(TBV)と局所灰白質容積をvoxel-based morphometryを用いて推定した。頭蓋内脳容積(ICV)に対するWMLVの比(WMLV/ICV)を計算し、WMLV/ICVと認知症リスクの関連をCox比例ハザードモデルにより推定した。ICVに対するTBVの比(TBV/ICV)で定義された全脳萎縮と、著者等の過去の報告で定義された認知症関連の脳局所萎縮を算出した。5年間の経過観察期間中に113人が認知症を発症した。認知症リスクはWMLV/ICVとともに有意に増加した。WMLV/ICVが大きくTBV/ICVが小さい住民と、WMLV/ICVが大きく認知症関連の脳局所萎縮の数が多い住民では認知症リスクが相加的に増加することが観察された。

  • 日本の地域における10年間の血清エイコサペンタエン酸/アラキドン酸比の変化 久山町研究(Changes in the Eicosapentaenoic Acid to Arachidonic Acid Ratio in Serum over 10 Years in a Japanese Community: The Hisayama Study)

    Honda Takanori, Chen Sanmei, Hata Jun, Shibata Mao, Furuta Yoshihiko, Oishi Emi, Sakata Satoko, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   30 ( 6 )   589 - 600   2023.6   ISSN:1340-3478

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    日本の集団ベース研究である久山町研究のデータを用いて、集団レベルでの血清エイコサペンタエン酸(EPA)/アラキドン酸(AA)比、血清EPA濃度、血清AA濃度の10年間の変化を評価した。2002~2003年と2012~2013年に久山町研究に参加した40歳以上でEPA薬を服用していない地域住民(2002~2003年は3194名、2012~2013年は3220名)のデータを解析した。血清EPA/AA比は10年間で低下し、2002年と2012年の幾何平均値はそれぞれ0.40、0.32であった。血清EPA濃度は軽度に上昇し、2002年と2012年の幾何平均値はそれぞれ59.0μg/mL、65.1μg/mLであった。血清AA濃度は大きく上昇し、2002年と2012年の幾何平均値はそれぞれ147.6μg/mL、199.9μg/mLであった。年齢群別の解析では、血清EPA/AA比は80歳以上を除いて有意に低下し、若年群ほど低下が大きかった。血清EPA濃度は50~59歳で有意に低下し、70歳以上で有意に上昇した。血清AA濃度はすべての年齢群で有意に上昇した。

  • Decreased Estimated Glomerular Filtration Rate and Proteinuria and Long-Term Outcomes After Ischemic Stroke: A Longitudinal Observational Cohort Study

    Kana Ueki, Ryu Matsuo, Takahiro Kuwashiro, Fumi Irie, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono, Takao Ishitsuka, Setsuro Ibayashi, Kenji Kusuda, Kenichiro Fujii, Tetsuhiko Nagao, Yasushi Okada, Masahiro Yasaka, Hiroaki Ooboshi, Katsumi Irie, Tsuyoshi Omae, Kazunori Toyoda, Hiroshi Nakane, Hiroshi Sugimori, Shuji Arakawa, Kenji Fukuda, Jiro Kitayama, Shigeru Fujimoto, Shoji Arihiro, Junya Kuroda, Yoshihisa Fukushima, Kuniyuki Nakamura, Takuya Kiyohara, Jun Hata, Yasuhiro Kumai

    Stroke   54 ( 5 )   1268 - 1277   2023.5   ISSN:0039-2499 eISSN:1524-4628

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    Background: It remains unclear how chronic kidney disease and its underlying pathological conditions, kidney dysfunction, and kidney damage, are associated with cardiovascular outcomes. This study aimed to determine whether kidney dysfunction (ie, decreased estimated glomerular filtration rate), kidney damage (ie, proteinuria), or both are associated with the long-term outcomes after ischemic stroke. Methods: A total of 12 576 patients (mean age, 73.0±12.6 years; 41.3% women) with ischemic stroke who were registered in a hospital-based multicenter registry, Fukuoka Stroke Registry, between June 2007 and September 2019, were prospectively followed up after stroke onset. Kidney function was assessed by estimated glomerular filtration rate and categorized into G1: ≥60 mL/(min·1.73 m2), G2: 45-59 mL/(min·1.73 m2), and G3: <45 mL/(min·1.73 m2). Kidney damage was evaluated by proteinuria using a urine dipstick test and classified into P1: -, P2: ±/1+, and P3: ≥2+. Hazard ratios and 95% CI for events of interest were estimated by a Cox proportional hazards model. Long-term outcomes included recurrence of stroke and all-cause death. Results: During the median follow-up of 4.3 years (interquartile range, 2.1-7.3 years), 2481 patients had recurrent stroke (48.0/1000 patient-years) and 4032 patients died (67.3/1000 patient-years). Chronic kidney disease was independently associated with increased risks of stroke recurrence and all-cause death even after adjustment for multiple confounding factors, including traditional cardiovascular risk factors. Both estimated glomerular filtration rate and proteinuria were independently associated with increased risks of stroke recurrence (multivariable-adjusted hazard ratio [95% CI], G3: 1.22 [1.09-1.37] versus G1, P3: 1.25 [1.07-1.46] versus P1) and death (G3: 1.45 [1.33-1.57] versus G1, P3: 1.62 [1.45-1.81] versus P1). In subgroup analyses, effect modifications were found in the association of proteinuria with death by age and stroke subtype. Conclusions: Kidney dysfunction and kidney damage were independently, but differently, associated with increased risks of recurrent stroke and all-cause death.

    DOI: 10.1161/STROKEAHA.122.040958

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  • CKD, Brain Atrophy, and White Matter Lesion Volume: The Japan Prospective Studies Collaboration for Aging and Dementia. International journal

    Kenji Maki, Tomoyuki Ohara, Jun Hata, Mao Shibata, Naoki Hirabayashi, Takanori Honda, Satoko Sakata, Yoshihiko Furuta, Masato Akiyama, Keisuke Yamasaki, Yasuko Tatewaki, Yasuyuki Taki, Takanari Kitazono, Tatsuya Mikami, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya

    Kidney medicine   5 ( 3 )   100593 - 100593   2023.3

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    RATIONALE & OBJECTIVE: Chronic kidney disease, defined by albuminuria and/or reduced estimated glomerular filtration rate (eGFR), has been reported to be associated with brain atrophy and/or higher white matter lesion volume (WMLV), but there are few large-scale population-based studies assessing this issue. This study aimed to examine the associations between the urinary albumin-creatinine ratio (UACR) and eGFR levels and brain atrophy and WMLV in a large-scale community-dwelling older population of Japanese. STUDY DESIGN: Population-based cross-sectional study. SETTING & PARTICIPANTS: A total of 8,630 dementia-free community-dwelling Japanese aged greater than or equal to 65 years underwent brain magnetic resonance imaging scanning and screening examination of health status in 2016-2018. EXPOSURES: UACR and eGFR levels. OUTCOMES: The total brain volume (TBV)-to-intracranial volume (ICV) ratio (TBV/ICV), the regional brain volume-to-TBV ratio, and the WMLV-to-ICV ratio (WMLV/ICV). ANALYTICAL APPROACH: The associations of UACR and eGFR levels with the TBV/ICV, the regional brain volume-to-TBV ratio, and the WMLV/ICV were assessed by using an analysis of covariance. RESULTS: Higher UACR levels were significantly associated with lower TBV/ICV and higher geometric mean values of the WMLV/ICV (P for trend = 0.009 and <0.001, respectively). Lower eGFR levels were significantly associated with lower TBV/ICV, but not clearly associated with WMLV/ICV. In addition, higher UACR levels, but not lower eGFR, were significantly associated with lower temporal cortex volume-to-TBV ratio and lower hippocampal volume-to-TBV ratio. LIMITATIONS: Cross-sectional study, misclassification of UACR or eGFR levels, generalizability to other ethnicities and younger populations, and residual confounding factors. CONCLUSIONS: The present study demonstrated that higher UACR was associated with brain atrophy, especially in the temporal cortex and hippocampus, and with increased WMLV. These findings suggest that chronic kidney disease is involved in the progression of morphologic brain changes associated with cognitive impairment.

    DOI: 10.1016/j.xkme.2022.100593

  • Secular trends in the prevalence, incidence, and progression of diabetic retinopathy: the Hisayama Study Reviewed International journal

    Hashimoto S, Yasuda M, Fujiwara K, Ueda E, Nakamura S, Hirakawa Y, Higashioka M, Hata J, Ninomiya T, Sonoda KH.

    Graefes Arch Clin Exp Ophthalmol   2023.3

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    DOI: 10.1007/s00417-022-05839-8

  • Association of gait speed with regional brain volumes and risk of dementia in older Japanese: the Hisayama study Reviewed International journal

    Tajimi T, Furuta Y, Hirabayashi N, Honda T, Hata J, Ohara T, Shibata M, Nakao T, Kitazono T, Nakashima Y, Ninomiya T.

    Arch Gerontol Geriatr   2023.3

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    DOI: 10.1016/j.archger.2022.104883

  • Diminishing benefits of urban living for children and adolescents' growth and development Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Nature   2023.3

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    DOI: 10.1038/s41586-023-05772-8

  • 地域住民における角膜ヒステリシスと緑内障の関連 久山町研究

    藤原 康太, 上田 瑛美, 橋本 左和子, 中村 駿, 秦 淳, 中野 聡子, 村上 祐介, 久保田 敏昭, 吉冨 健志, 二宮 利治, 園田 康平

    日本眼科学会雑誌   127 ( 臨増 )   220 - 220   2023.3   ISSN:0029-0203

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  • CKD, brain atrophy, and white matter lesion volume: the Japan Prospective Studies Collaboration for Aging and Dementia Reviewed International journal

    Maki K, Ohara T, Hata J, Shibata M, Hirabayashi N, Honda T, Sakata S, Furuta Y, Akiyama M, Yamasaki K, Tatewaki Y, Taki Y, Kitazono T, Mikami T, Maeda T, Ono K, Mimura M, Nakashima K, Iga JI, Takebayashi M, Ninomiya T; Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) study group.

    Kidney Med   2022.12

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    DOI: 10.1016/j.xkme.2022.100593

  • 日本の一地域で半世紀にわたり示された再発性脳卒中5年リスクの長期傾向 久山町研究(Long-Term Trends in The 5-Year Risk of Recurrent Stroke over A Half Century in A Japanese Community: The Hisayama Study)

    Nakanishi Yasuyuki, Furuta Yoshihiko, Hata Jun, Yubi Tomohiro, Oishi Emi, Sakata Satoko, Hirakawa Yoichiro, Wakisaka Yoshinobu, Ago Tetsuro, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   29 ( 12 )   1759 - 1773   2022.12   ISSN:1340-3478

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    一般日本人集団の前向き追跡データを用いて、再発性脳卒中の5年リスクにみられる傾向を半世紀にわたり検討した。福岡県久山町の住民を対象に、1961年から続けられている久山町研究のデータを利用した。1961年(154名)、1974年(144名)、1988年(172名)、2002年(146名)を起点とする四つのコホートを設定し、脳卒中発症患者を起点から10年間追跡したデータを用いて再発性脳卒中リスクを調査した。全種類の脳卒中および虚血性脳卒中を発症した後の再発性脳卒中リスクは、一番目(1961年)のコホートから三番目のコホートにかけて有意に低下していたが、三番目から四番目のコホートでは明瞭な変化は示されなかった。出血性脳卒中後の同リスクは主として一番目から二番目のコホートにかけて低下しており、二番目から四番目まででは明らかな低下はみられなかった。こうした傾向は年齢・性別で調整しても実質的に不変であった。

  • Prevalence of glaucoma and its systemic risk factors in a general Japanese population: the Hisayama Study Reviewed International journal

    Fujiwara K, Yasuda M, Hata J, Nakano S, Hashimoto S, Ueda E, Nakamura S, Murakami Y, Nakamuro T, Iwase A, Araie M, Tawara A, Kubota T, Yoshitomi T, Ninomiya T, Sonoda KH.

    Transl Vis Sci Technol   2022.11

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    DOI: 10.1167/tvst.11.11.11

  • Mild-to-moderate kidney dysfunction and cardiovascular disease: observational and mendelian randomization analyses Reviewed International journal

    Gaziano L, Sun L, Arnold M, Bell S, Cho K, Kaptoge SK, Song RJ, Burgess S, Posner DC, Mosconi K, Robinson-Cohen C, Mason AM, Bolton TR, Tao R, Allara E, Schubert P, Chen L, Staley JR, Staplin N, Altay S, Amiano P, Arndt V, Ärnlöv J, Barr ELM, Björkelund C, Boer JMA, Brenner H, Casiglia E, Chiodini P, Cooper JA, Coresh J, Cushman M, Dankner R, Davidson KW, de Jongh RT, Donfrancesco C, Engström G, Freisling H, de la Cámara AG, Gudnason V, Hankey GJ, Hansson PO, Heath AK, Hoorn EJ, Imano H, Jassal SK, Kaaks R, Katzke V, Kauhanen J, Kiechl S, Koenig W, Kronmal RA, Kyrø C, Lawlor DA, Ljungberg B, MacDonald C, Masala G, Meisinger C, Melander O, Moreno Iribas C, Ninomiya T, Nitsch D, Nordestgaard BG, Onland-Moret C, Palmieri L, Petrova D, Garcia JRQ, Rosengren A, Sacerdote C, Sakurai M, Santiuste C, Schulze MB, Sieri S, Sundström J, Tikhonoff V, Tjønneland A, Tong T, Tumino R, Tzoulaki I, van der Schouw YT, Monique Verschuren WM, Völzke H, Wallace RB, Wannamethee SG, Weiderpass E, Willeit P, Woodward M, Yamagishi K, Zamora-Ros R, Akwo EA, Pyarajan S, Gagnon DR, Tsao PS, Muralidhar S, Edwards TL, Damrauer SM, Joseph J, Pennells L, Wilson PWF, Harrison S, et al.

    Circulation   2022.11

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    DOI: 10.1161/CIRCULATIONAHA.122.060700

  • Stroke genetics informs drug discovery and risk prediction across ancestries Reviewed International journal

    Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, He Y, Georgakis MK, Caro I, Krebs K, Liaw YC, Vaura FC, Lin K, Winsvold BS, Srinivasasainagendra V, Parodi L, Bae HJ, Chauhan G, Chong MR, Tomppo L, Akinyemi R, Roshchupkin GV, Habib N, Jee YH, Thomassen JQ, Abedi V, Cárcel-Márquez J, Nygaard M, Leonard HL, Yang C, Yonova-Doing E, Knol MJ, Lewis AJ, Judy RL, Ago T, Amouyel P, Armstrong ND, Bakker MK, Bartz TM, Bennett DA, Bis JC, Bordes C, Børte S, Cain A, Ridker PM, Cho K, Chen Z, Cruchaga C, Cole JW, de Jager PL, de Cid R, Endres M, Ferreira LE, Geerlings MI, Gasca NC, Gudnason V, Hata J, He J, Heath AK, Ho YL, Havulinna AS, Hopewell JC, Hyacinth HI, Inouye M, Jacob MA, Jeon CE, Jern C, Kamouchi M, Keene KL, Kitazono T, Kittner SJ, Konuma T, Kumar A, Lacaze P, Launer LJ, Lee KJ, Lepik K, Li J, Li L, Manichaikul A, Markus HS, Marston NA, Meitinger T, Mitchell BD, Montellano FA, Morisaki T, Mosley TH, Nalls MA, Nordestgaard BG, O'Donnell MJ, Okada Y, Onland-Moret NC, Ovbiagele B, Peters A, Psaty BM, Rich SS, et al.

    Nature   2022.11

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    DOI: 10.1038/s41586-022-05165-3

  • Day-to-day blood pressure variability and risk of incident chronic kidney disease in a general Japanese population Reviewed International journal

    Sasaki T, Sakata S, Oishi E, Furuta Y, Honda T, Hata J, Tsuboi N, Kitazono T, Yokoo T, Ninomiya T.

    J Am Heart Assoc   2022.10

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    DOI: 10.1161/JAHA.122.027173

  • 活動的通勤および通勤形態と糖尿病リスクについて 久山町研究の14年間の追跡データ(Active commuting, commuting modes and the risk of diabetes: 14-year follow-up data from the Hisayama study)

    Honda Takanori, Hirakawa Yoichiro, Hata Jun, Chen Sanmei, Shibata Mao, Sakata Satoko, Furuta Yoshihiko, Higashioka Mayu, Oishi Emi, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Diabetes Investigation   13 ( 10 )   1677 - 1684   2022.10   ISSN:2040-1116

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    通勤手段の違いが糖尿病発症リスクに及ぼす影響について検討した。対象は福岡県久山町の住民検診を受診した40~79歳の住民1208名で、通勤手段に徒歩か自転車を含む活動的通勤者が189名、自動車や公共交通機関のみの非活動的通勤者が653名、非通勤者が366名であった。追跡期間中央値14年で191名が糖尿病を発症した。Cox比例ハザードモデルによる解析の結果、活動的通勤者は非活動的通勤者に比べて糖尿病発症リスクが有意に低かった(調整HR 0.54、95%CI 0.31~0.92、p=0.02)。通勤形態別にみた糖尿病発症のHR(95%CI)は、非活動的通勤者を基準として、自転車のみが0.46(0.22~0.98、p=0.04)、徒歩のみが0.14(0.02~1.02、p=0.053)であった。徒歩と非活動的通勤手段の併用は、糖尿病発症リスクの低下と関連しなかった(HR 1.69、95%CI 0.77~3.71)。

  • Altruistic social activity, depressive symptoms, and brain regional gray matter volume: voxel-based morphometry analysis from 8,695 old adults Reviewed International journal

    Liu Y, Zhang Y, Thyreau B, Tatewaki Y, Matsudaira I, Takano Y, Hirabayashi N, Furuta Y, Hata J, Ninomiya T, Taki Y; Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) Study Group.

    J Gerontol A Biol Sci Med Sci   2022.9

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    DOI: 10.1093/gerona/glac093

  • 21世紀の冠動脈疾患の予防:リスクスコアや新たな検査・薬剤をどう使いこなすか? 日本人を対象とした動脈硬化性疾患の新しい発症リスク予測モデル;久山町研究

    秦 淳, 本田 貴紀, 陳 三妹, 二宮 利治, 川久保 裕美子

    日本心臓病学会学術集会抄録   70回   S11 - 1   2022.9

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  • Association of the prefrailty with global brain atrophy and white matter lesions among cognitively unimpaired older adults: the Nakajima study Reviewed International journal

    Noguchi-Shinohara M, Ono K, Yuki-Nozaki S, Iwasa K, Yokogawa M, Komai K, Thyreau B, Tatewaki Y, Taki Y, Shibata M, Ohara T, Hata J, Ninomiya T, Yamada M.

    Sci Rep   2022.8

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    DOI: 10.1038/s41598-022-16190-7

  • Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community Reviewed International journal

    Mihara A, Ohara T, Hata J, Chen S, Honda T, Tamrakar S, Isa A, Wang D, Shimizu K, Katakura Y, Yonemoto K, Nakao T, Kitazono T, Ninomiya T.

    Sci Rep   2022.7

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    DOI: 10.1038/s41598-022-16242-y

  • 動脈硬化性疾患予防ガイドライン2022と今後の展望 地域住民における動脈硬化性疾患発症のリスク予測モデルと「久山町スコア」の作成 久山町研究

    本田 貴紀, 陳 三妹, 秦 淳, 吉田 大悟, 平川 洋一郎, 古田 芳彦, 柴田 舞欧, 坂田 智子, 北園 孝成, 二宮 利治

    日本動脈硬化学会総会プログラム・抄録集   54回   137 - 137   2022.7   ISSN:1347-7099

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  • Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations Reviewed International journal

    Gerard Temprano‐Sagrera, Colleen M. Sitlani, William P. Bone, Miguel Martin‐Bornez, Benjamin F. Voight, Alanna C. Morrison, Scott M. Damrauer, Paul S. de Vries, Nicholas L. Smith, Maria Sabater‐Lleal, Abbas Dehghan, Adam S Heath, Alanna C Morrison, Alex P Reiner, Andrew Johnson, Anne Richmond, Annette Peters, Astrid van Hylckama Vlieg, Barbara McKnight, Bruce M Psaty, Caroline Hayward, Cavin Ward‐Caviness, Christopher O’Donnell, Daniel Chasman, David P Strachan, David A Tregouet, Dennis Mook‐Kanamori, Dipender Gill, Florian Thibord, Folkert W Asselbergs, Frank W.G. Leebeek, Frits R Rosendaal, Gail Davies, Georg Homuth, Gerard Temprano, Harry Campbell, Herman A Taylor, Jan Bressler, Jennifer E Huffman, Jerome I Rotter, Jie Yao, James F Wilson, Joshua C Bis, Julie M Hahn, Karl C Desch, Kerri L Wiggins, Laura M Raffield, Lawrence F Bielak, Lisa R Yanek, Marcus E Kleber, Maria Sabater‐Lleal, Martina Mueller, Maryam Kavousi, Massimo Mangino, Melissa Liu, Michael R Brown, Matthew P Conomos, Min‐A Jhun, Ming‐Huei Chen, Moniek P.M. de Maat, Nathan Pankratz, Nicholas L Smith, Patricia A Peyser, Paul Elliot, Paul S de Vries, Peng Wei, Philipp S Wild, Pierre E Morange, Pim van der Harst, Qiong Yang, Ngoc‐Quynh Le, Riccardo Marioni, Ruifang Li, Scott M Damrauer, Simon R Cox, Stella Trompet, Stephan B Felix, Uwe Völker, Weihong Tang, Wolfgang Koenig, J. Wouter Jukema, Xiuqing Guo, Sara Lindstrom, Lu Wang, Erin N Smith, William Gordon, Astrid van Hylckama Vlieg, Mariza de Andrade, Jennifer A Brody, Jack W Pattee, Jeffrey Haessler, Ben M Brumpton, Daniel I Chasman, Pierre Suchon, Ming‐Huei Chen, Constance Turman, Marine Germain, Kerri L Wiggins, James MacDonald, Sigrid K Braekkan, Sebastian M Armasu, Nathan Pankratz, Rabecca D Jackson, Jonas B Nielsen, Franco Giulianini, Marja K Puurunen, Manal Ibrahim, Susan R Heckbert, Theo K Bammler, Kelly A Frazer, Bryan M McCauley, Kent Taylor, James S Pankow, Alexander P Reiner, Maiken E Gabrielsen, Jean‐François Deleuze, Chris J O’Donnell, Jihye Kim, Barbara McKnight, Peter Kraft, John‐Bjarne Hansen, Frits R Rosendaal, John A Heit, Bruce M Psaty, Weihong Tang, Charles Kooperberg, Kristian Hveem, Paul M Ridker, Pierre‐Emmanuel Morange, Andrew D Johnson, Christopher Kabrhel, David‐Alexandre Trégouët, Nicholas L Smith, Rainer Malik, Ganesh Chauhan, Matthew Traylor, Muralidharan Sargurupremraj, Yukinori Okada, Aniket Mishra, Loes Rutten‐Jacobs, Anne‐Katrin Giese, Sander W van der Laan, Solveig Gretarsdottir, Christopher D Anderson, Michael Chong, Hieab HH Adams, Tetsuro Ago, Peter Almgren, Philippe Amouyel, Hakan Ay, Traci M Bartz, Oscar R Benavente, Steve Bevan, Giorgio B Boncoraglio, Robert D Brown, Adam S Butterworth, Caty Carrera, Cara L Carty, Daniel I Chasman, Wei‐Min Chen, John W Cole, Adolfo Correa, Ioana Cotlarciuc, Carlos Cruchaga, John Danesh, Paul IW de Bakker, Anita L DeStefano, Marcel den Hoed, Qing Duan, Stefan T Engelter, Guido J Falcone, Rebecca F Gottesman, Raji P Grewal, Vilmundur Gudnason, Stefan Gustafsson, Jeffrey Haessler, Tamara B Harris, Ahamad Hassan, Aki S Havulinna, Susan R Heckbert, Elizabeth G Holliday, George Howard, Fang‐Chi Hsu, Hyacinth I Hyacinth, M Arfan Ikram, Erik Ingelsson, Marguerite R Irvin, Xueqiu Jian, Jordi Jiménez‐Conde, Julie A Johnson, J Wouter Jukema, Masahiro Kanai, Keith L Keene, Brett M Kissela, Dawn O Kleindorfer, Charles Kooperberg, Michiaki Kubo, Leslie A Lange, Carl D Langefeld, Claudia Langenberg, Lenore J Launer, Jin‐Moo Lee, Robin Lemmens, Didier Leys, Cathryn M Lewis, Wei‐Yu Lin, Arne G Lindgren, Erik Lorentzen, Patrik K Magnusson, Jane Maguire, Ani Manichaikul, Patrick F McArdle, James F Meschia, Braxton D Mitchell, Thomas H Mosley, Michael A Nalls, Toshiharu Ninomiya, Martin J O’Donnell, Bruce M Psaty, Sara L Pulit, Kristiina Rannikmäe, Alexander P Reiner, Kathryn M Rexrode, Kenneth Rice, Stephen S Rich, Paul M Ridker, Natalia S Rost, Peter M Rothwell, Jerome I Rotter, Tatjana Rundek, Ralph L Sacco, Saori Sakaue, Michele M Sale, Veikko Salomaa, Bishwa R Sapkota, Reinhold Schmidt, Carsten O Schmidt, Ulf Schminke, Pankaj Sharma, Agnieszka Slowik, Cathie LM Sudlow, Christian Tanislav, Turgut Tatlisumak, Kent D Taylor, Vincent NS Thijs, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Steffen Tiedt, Stella Trompet, Christophe Tzourio, Cornelia M van Duijn, Matthew Walters, Nicholas J Wareham, Sylvia Wassertheil‐Smoller, James G Wilson, Kerri L Wiggins, Qiong Yang, Salim Yusuf, Najaf Amin, Hugo S Aparicio, Donna K Arnett, John Attia, Alexa S Beiser, Claudine Berr, Julie E Buring, Mariana Bustamante, Valeria Caso, Yu‐Ching Cheng, Seung Hoan Choi, Ayesha Chowhan, Natalia Cullell, Jean‐François Dartigues, Hossein Delavaran, Pilar Delgado, Marcus Dörr, Gunnar Engström, Ian Ford, Wander S Gurpreet, Anders Hamsten, Laura Heitsch, Atsushi Hozawa, Laura Ibanez, Andreea Ilinca, Martin Ingelsson, Motoki Iwasaki, Rebecca D Jackson, Katarina Jood, Pekka Jousilahti, Sara Kaffashian, Lalit Kalra, Masahiro Kamouchi, Takanari Kitazono, Olafur Kjartansson, Manja Kloss, Peter J Koudstaal, Jerzy Krupinski, Daniel L Labovitz, Cathy C Laurie, Christopher R Levi, Linxin Li, Lars Lind, Cecilia M Lindgren, Vasileios Lioutas, Yong Mei Liu, Oscar L Lopez, Hirata Makoto, Nicolas Martinez‐Majander, Koichi Matsuda, Naoko Minegishi, Joan Montaner, Andrew P Morris, Elena Muiño, Martina Müller‐Nurasyid, Bo Norrving, Soichi Ogishima, Eugenio A Parati, Leema Reddy Peddareddygari, Nancy L Pedersen, Joanna Pera, Markus Perola, Alessandro Pezzini, Silvana Pileggi, Raquel Rabionet, Iolanda Riba‐Llena, Marta Ribasés, Jose R Romero, Jaume Roquer, Anthony G Rudd, Antti‐Pekka Sarin, Ralhan Sarju, Chloe Sarnowski, Makoto Sasaki, Claudia L Satizabal, Mamoru Satoh, Naveed Sattar, Norie Sawada, Gerli Sibolt, Ásgeir Sigurdsson, Albert Smith, Kenji Sobue, Carolina Soriano‐Tárraga, Tara Stanne, O Colin Stine, David J Stott, Konstantin Strauch, Takako Takai, Hideo Tanaka, Kozo Tanno, Alexander Teumer, Liisa Tomppo, Nuria P Torres‐Aguila, Emmanuel Touze, Shoichiro Tsugane, Andre G Uitterlinden, Einar M Valdimarsson, Sven J van der Lee, Henry Völzke, Kenji Wakai, David Weir, Stephen R Williams, Charles DA Wolfe, Quenna Wong, Huichun Xu, Taiki Yamaji, Dharambir K Sanghera, Olle Melander, Christina Jern, Daniel Strbian, Israel Fernandez‐Cadenas, W T Longstreth, Arndt Rolfs, Jun Hata, Daniel Woo, Jonathan Rosand, Guillaume Pare, Jemma C Hopewell, Danish Saleheen, Kari Stefansson, Bradford B Worrall, Steven J Kittner, Sudha Seshadri, Myriam Fornage, Hugh S Markus, Joanna MM Howson, Yoichiro Kamatani, Stephanie Debette, Martin Dichgans

    Journal of Thrombosis and Haemostasis   20 ( 6 )   1331 - 1349   2022.6

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    DOI: 10.1111/jth.15698

  • Association between diabetes and gray matter atrophy patterns in a general older Japanese population: the Hisayama Study Reviewed International journal

    Hirabayashi N, Hata J, Furuta Y, Ohara T, Shibata M, Hirakawa Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Ninomiya T.

    Diabetes Care   2022.6

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    DOI: 10.2337/dc21-1911

  • 地域高齢者における交流頻度と脳萎縮の関連 JPSC-AD研究

    平林 直樹, 本田 貴紀, 秦 淳, 古田 芳彦, 柴田 舞欧, 小原 知之, 須藤 信行, 二宮 利治

    日本心身医学会総会ならびに学術講演会プログラム・抄録集   63回   150 - 150   2022.6

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  • Higher-resolution quantification of white matter hypointensities by large-scale transfer learning from 2D images on the JPSC-AD cohort Reviewed International journal

    Thyreau B, Tatewaki Y, Chen L, Takano Y, Hirabayashi N, Furuta Y, Hata J, Nakaji S, Maeda T, Noguchi-Shinohara M, Mimura M, Nakashima K, Mori T, Takebayashi M, Ninomiya T, Taki Y; Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) Study Group.

    Hum Brain Mapp   2022.5

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    DOI: 10.1002/hbm.25899

  • Active commuting, commuting modes and the risk of diabetes: 14-year follow-up data from the Hisayama Study Reviewed International journal

    Honda T, Hirakawa Y, Hata J, Chen S, Shibata M, Sakata S, Furuta Y, Higashioka M, Oishi E, Kitazono T, Ninomiya T.

    J Diabetes Investig   2022.5

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    DOI: 10.1111/jdi.13844

  • Risks of mortality and airflow limitation in Japanese with preserved ratio impaired spirometry Reviewed International journal

    Washio Y, Sakata S, Fukuyama S, Honda T, Kan-O K, Shibata M, Hata J, Inoue H, Kitazono T, Matsumoto K, Ninomiya T.

    Am J Respir Crit Care Med   2022.5

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    DOI: 10.1164/rccm.202110-2302OC

  • Yogurt product intake and reduction of tooth loss risk in a Japanese community Reviewed International journal

    Ma J, Furuta M, Uchida K, Takeshita T, Kageyama S, Asakawa M, Takeuchi K, Suma S, Sakata S, Hata J, Sohn W, Ninomiya T, Yamashita Y.

    J Clin Periodontol   2022.4

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    DOI: 10.1111/jcpe.13593

  • Association of inner retinal thickness with prevalent dementia and brain atrophy in a general older population: the Hisayama Study Reviewed International journal

    Ueda E, Hirabayashi N, Ohara T, Hata J, Honda T, Fujiwara K, Furuta Y, Shibata M, Hashimoto S, Nakamura S, Nakazawa T, Nakao T, Kitazono T, Ninomiya T, Sonoda KH.

    Ophthalmol Sci   2022.4

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    DOI: 10.1016/j.xops.2022.100157

  • Baseline periodontal status and modifiable risk factors are associated with tooth loss over a 10-year period: estimates of population attributable risk in a Japanese community Reviewed International journal

    Furuta M, Takeuchi K, Takeshita T, Shibata Y, Suma S, Kageyama S, Asakawa M, Shimazaki Y, Hata J, Ninomiya T, Yamashita Y.

    J Periodontol   2022.4

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    DOI: 10.1002/JPER.21-0191

  • Association of daily sleep duration with the incident dementia by serum soluble TREM2 in a community Reviewed International journal

    Ohara T, Hata J, Tanaka M, Honda T, Yamakage H, Inoue T, Hirakawa Y, Kusakabe T, Shibata M, Kitazono T, Nakao T, Satoh-Asahara N, Ninomiya T.

    J Am Geriatr Soc   2022.4

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    DOI: 10.1111/jgs.17634

  • 地域住民における血清メチオニン代謝産物濃度と認知症発症および死亡リスクの関連 久山町研究

    三原 茜, 小原 知之, 秦 淳, 陳 三妹, 本田 貴紀, Tamrakar Sonam, 伊佐 亜希子, 王 冬梅, 清水 邦義, 片倉 喜範, 中尾 智博, 北園 孝成, 二宮 利治

    精神神経学雑誌   124 ( 4付録 )   S - 368   2022.4   ISSN:0033-2658

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  • Development and validation of a risk prediction model for atherosclerotic cardiovascular disease in Japanese adults: the Hisayama Study Reviewed

    Honda T, Chen S, Hata J, Yoshida D, Hirakawa Y, Furuta Y, Shibata M, Sakata S, Kitazono T, Ninomiya T.

    J Atheroscler Thromb   2022.3

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    DOI: 10.5551/jat.61960

  • Long-term association of vegetable and fruit intake with risk of dementia in Japanese older adults: the Hisayama Study Reviewed International journal

    Kimura Y, Yoshida D, Ohara T, Hata J, Honda T, Hirakawa Y, Shibata M, Oishi E, Sakata S, Furuta Y, Chen S, Uchida K, Nakao T, Kitazono T, Ninomiya T.

    BMC Geriatr   2022.3

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    DOI: 10.1186/s12877-022-02939-2

  • Association between chronic low back pain and regional brain atrophy in a Japanese older population: the Hisayama Study Reviewed International journal

    Asada M, Shibata M, Hirabayashi N, Ohara T, Furuta Y, Nakazawa T, Honda T, Hata J, Hosoi M, Sudo N, Yamaura K, Ninomiya T.

    Pain   2022.3

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    DOI: 10.1097/j.pain.0000000000002612

  • Multiple-region grey matter atrophy as a predictor for the development of dementia in a community: the Hisayama Study Reviewed International journal

    Nakazawa T, Ohara T, Hirabayashi N, Furuta Y, Hata J, Shibata M, Honda T, Kitazono T, Nakao T, Ninomiya T.

    J Neurol Neurosurg Psychiatry   2022.3

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    DOI: 10.1136/jnnp-2021-326611

  • 日本人成人における動脈硬化性心血管疾患リスクの予測モデルの開発および検証 久山町研究(Development and Validation of a Risk Prediction Model for Atherosclerotic Cardiovascular Disease in Japanese Adults: The Hisayama Study)

    Honda Takanori, Chen Sanmei, Hata Jun, Yoshida Daigo, Hirakawa Yoichiro, Furuta Yoshihiko, Shibata Mao, Sakata Satoko, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   29 ( 3 )   345 - 361   2022.3   ISSN:1340-3478

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    心血管疾患の既往がない成人被験者2454名(男性1026名、女性1428名、平均58.2±11.1歳)を対象に、Cox比例ハザードモデルを用いてアテローム動脈硬化性心血管疾患(ASCVD)発症のリスク予測モデルを開発し、妥当性を検証した。対象は久山町研究に参加した40歳から84歳までの一般住民で、ASCVDは冠状動脈性心疾患またはアテローム血栓性脳梗塞と定義した。平均追跡期間は24年で、ASCVDは270名で初発した。発生率は1000人あたり5.8人年であった。リスク予測モデルの予測因子として年齢、性別、収縮期血圧、糖尿病、血中HDLコレステロール、LDLコレステロール、蛋白尿、喫煙習慣、定期的な運動を選択した。上記の変数を組み込んで10年後のASCVD発症予測モデルを構築し、簡便なリスクスコアを作成した。C統計量により妥当性を評価したところ、ASCVD発症リスク予測モデル(0.786)と簡便なリスクスコア(0.789)のいずれも優れた識別能を呈した。またGreenwood-Nam-D' Agostino検定で良好なキャリブレーションが確認された(それぞれP=0.29とP=0.52)。

  • Changes in body weight and concurrent changes in cardiovascular risk profiles in community residents in Japan: the Hisayama Study Reviewed

    Honda T, Ishida Y, Oda M, Noguchi K, Chen S, Sakata S, Oishi E, Furuta Y, Yoshida D, Hirakawa Y, Hata J, Kitazono T, Ninomiya T.

    J Atheroscler Thromb   2022.2

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    DOI: 10.5551/jat.59394

  • Long-term trends in the 5-year risk of recurrent stroke over a half century in a Japanese community: the Hisayama Study Reviewed

    Nakanishi Y, Furuta Y, Hata J, Yubi T, Oishi E, Sakata S, Hirakawa Y, Wakisaka Y, Ago T, Kitazono T, Ninomiya T.

    J Atheroscler Thromb   2022.2

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    DOI: 10.5551/jat.63344

  • 日本の地域住民における体重変化と心血管リスクプロファイルの同時変化 久山町研究(Changes in Body Weight and Concurrent Changes in Cardiovascular Risk Profiles in Community Residents in Japan: the Hisayama Study)

    Honda Takanori, Ishida Yuki, Oda Masaaki, Noguchi Kenichi, Chen Sanmei, Sakata Satoko, Oishi Emi, Furuta Yoshihiko, Yoshida Daigo, Hirakawa Yoichiro, Hata Jun, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   29 ( 2 )   252 - 267   2022.2   ISSN:1340-3478

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    体重変化が、モデルから予測される心血管疾患(CVD)の包括的リスクと個々の心血管リスクの変化に及ぼす影響について検討した。久山町研究の縦断データを用いて、2002年と2007年の健康診断に参加した40~74歳の地域住民2140名を対象に解析を行った。BMI 25kg/m2以上を肥満とし、2002年と2007年のBMIにより、「安定肥満」(両年とも肥満)、「肥満から非肥満」、「非肥満から肥満」、「安定非肥満」(両年とも肥満)に分類した。CVDの推定累積リスクおよびCVDリスク因子の2002年から2007年にかけての変化を群間比較した。2140名を解析対象とした。CVDの推定リスクは、2007年にかけて全ての群で増加した。CVDの推定リスクの増加は、「肥満から非肥満」群で最も小さく、「非肥満から肥満」群で最も大きかった。「肥満から非肥満」群は「安定肥満」群よりもウエスト周囲長、血圧、空腹時血糖値、血清HDLコレステロール値、血清トリグリセリド値、肝酵素の望ましい変化量が大きかった。全変数について、「非肥満から肥満」群と「安定非肥満」群では逆の傾向が認められた。以上から、肥満者での減量および非肥満者での過剰な体重増加の回避と、CVD包括的リスクおよび個々のCVDリスク要因に望ましい関連が認められた。

  • Stroke genetics informs drug discovery and risk prediction across ancestries

    Stéphanie Debette, Aniket Mishra, Rainer Malik, Tsuyoshi Hachiya, Tuuli Jürgenson, Shinichi Namba, Masaru Koido, Quentin Le Grand, Frederick Kamanu, Mingyang Shi, Yunye He, Marios Georgakis, Ilana Caro, Kristi Krebs, Felix Vaura, Naomi Habib, Bendik Winsvold, Yon Ho Jee, Jesper Qvist Thomassen, Vida Abedi, Jara Cárcel-Márquez, Kuang Lin, Marianne Nygaard, Ganesh Chauhan, Hampton Leonard, Chaojie Yang, Ekaterina Yonova-Doing, Maria Knol, Tetsuro Ago, Philippe Amouyel, Christopher Anderson, Nicole Armstrong, Mark Bakker, Traci Bartz, Joshua Bis, Constance Bordes, Sigrid Borte, Anael Cain, Paul Ridker, Zhengming Chen, Michael Chong, John Cole, Rafael de Cid, Matthias Endres, Leslie Ferreira, Natalie Gasca, Vilmundur Gudnason, Jun Hata, Aki Havulinna, Jemma Hopewell, Hyacinth Hyacinth, Michael Inouye, Mina Jacob, Christina  Jeon, Christina Jern, Masahiro Kamouchi, Keith Keene, Takanari Kitazono, Steven Kittner, Takahiro Konuma, Amit Kumar, Paul Lacaze, Lenore Launer, Kaido Lepik, Jiang Li, Liming Li, Ani Manichaikul, Hugh Markus, Nicholas Marston, Thomas Meitinger, Braxton Mitchell, Felipe Montellano, Takayuki Morisaki, Thomas Mosley, Mike Nalls, Børge Nordestgaard, Martin O'Donnell, Yukinori Okada, Guillaume Pare, Annette Peters, Bruce Psaty, Stephen Rich, Jonathan Rosand, Marc Sabatine, Ralph Sacco, Danish Saleheen, Else Charlotte Sandset, Muralidharan Sargurupremraj, Makoto Sasaki, Claudia Satizabal, Carsten Schmidt, Atsushi Shimizu, Nicholas Smith, Daniel Strbian, Yoichi Sutoh, Kozo Tanno, Steffen Tiedt, Nuria Torres-Aguila, David-Alexandre Trégouët, Stella Trompet, Anil Tuladhar, Anne Tybjærg-Hansen, Marion van Vugt, Riina Vibo, Kerri Wiggins, Daniel Woo, Huichun Xu, Qiong Yang, Mark Lathrop, Iona Millwood, Christian Gieger, Toshiharu Ninomiya, Hans Grabe, J Wouter Jukema, Ina Rissanen, Sudha Seshadri, William Longstreth, Daniel Chasman, Joanna Howson, Marguerite Irvin, Hieab Adams, Sylvia Wasssertheil-Smoller, Kaare Christensen, M. Arfan Ikram, Tatjana Rundek, Jerome Rotter, Moeen Riaz, Eleanor Simonsick, Janika Kõrv, Paulo França, Myriam Fornage, Ramin Zand, Kameshwar Prasad, Ruth Frikke-Schmidt, Frank-Erik de Leeuw, Thomas Liman, Karl Georg Haeusler, Ynte Ruigrok, Peter Heuschmann, Keum Jung, John-Anker Zwart, Teemu Niiranen, Christian Ruff, Israel Fernández-Cadenas, Robin Walters, Lili Milani, Yoichiro Kamatani, Martin Dichgans

    2022.1

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    Publisher:Research Square Platform LLC  

    Abstract

    Previous genome-wide association studies (GWAS) of stroke, the second leading cause of death, have been conducted in populations of predominantly European ancestry.1,2 We undertook cross-ancestry GWAS meta-analyses of stroke and its subtypes in 110,182 stroke patients (33% non-European) and 1,503,898 control individuals of five ancestries from population- and clinic-based studies, nearly doubling the number of cases in previous stroke GWAS. We identified association signals at 89 independent loci, of which 61 were novel. Effect sizes were overall highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis using a novel machine-learning approach,3 transcriptome and proteome-wide association analyses revealed putative causal genes (e.g. SH3PXD2A and FURIN) and variants (e.g. at GRK5 and NOS3). Using a novel three-pronged approach,4 we provided genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWAS with vascular risk factor GWAS (iPGS) showed strong prediction of ischemic stroke risk in European and, for the first time, East-Asian populations.5,6 The iPGS performed better than stroke PGS alone and better than previous best iPGS, in Europeans and East-Asians. Transferability of European-specific iPGS to East-Asians was limited. Stroke genetic risk scores were predictive of ischemic stroke independent of clinical risk factors in 52,600 clinical trial participants with cardiometabolic disease and performed considerably better than previous scores, both in Europeans and East-Asians. Altogether our results provide critical insight to inform biology, reveal potential drug targets for intervention, and provide genetic risk prediction tools across ancestries for targeted prevention.

    DOI: 10.21203/rs.3.rs-1175817/v1

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  • Day-by-day blood pressure variability in the subacute stage of ischemic stroke and long-term recurrence Reviewed International journal

    Fukuda K, Matsuo R, Kamouchi M, Kiyuna F, Sato N, Nakamura K, Hata J, Wakisaka Y, Ago T, Imaizumi T, Kai H, Kitazono T; FSR Investigators.

    Stroke   2022.1

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    DOI: 10.1161/STROKEAHA.120.033751

  • A comparative study of site-specific distribution of aging-related tau astrogliopathy and its risk factors between Alzheimer disease and cognitive healthy brains: the Hisayama Study Reviewed International journal

    Yagita K, Honda H, Ohara T, Hamasaki H, Koyama S, Noguchi H, Mihara A, Nakazawa T, Hata J, Ninomiya T, Iwaki T.

    J Neuropathol Exp Neurol   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jnen/nlab126

  • Diabetes mellitus, elevated hemoglobin A1c, and glycated albumin are associated with the presence of all-cause dementia and Alzheimer's disease: the JPSC-AD study Reviewed International journal

    Noguchi-Shinohara M, Yuki-Nozaki S, Abe C, Mori A, Horimoto M, Yokogawa M, Ishida N, Suga Y, Ishizaki J, Ishimiya M, Nakamura H, Komai K, Nakamura H, Shibata M, Ohara T, Hata J, Ninomiya T, Yamada M; Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) Study Group.

    J Alzheimers Dis   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3233/JAD-215153

  • Serum uric acid levels and nephrosclerosis in a population-based autopsy study: the Hisayama Study Reviewed International journal

    Maki K, Hata J, Sakata S, Oishi E, Furuta Y, Nakano T, Oda Y, Kitazono T, Ninomiya T.

    Am J Nephrol   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000521426

  • 中年期地域住民における要介護認定の危険因子の探索 福岡市地域包括ケア情報プラットフォームデータによる縦断的検討

    二宮 利治, 木村 安美, 本田 貴紀, 古田 芳彦, 吉田 大悟, 秦 淳

    総合健診   49 ( 1 )   178 - 178   2022.1   ISSN:1347-0086 eISSN:1884-4103

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    Language:Japanese   Publisher:(一社)日本総合健診医学会  

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  • 活動的な通勤および通勤形態と糖尿病発症リスクの関連 久山町研究

    本田 貴紀, 平川 洋一郎, 秦 淳, 陳 三妹, 柴田 舞欧, 坂田 智子, 古田 芳彦, 東岡 真由, 大石 絵美, 北園 孝成, 二宮 利治

    Journal of Epidemiology   32 ( Suppl.1 )   136 - 136   2022.1   ISSN:0917-5040 eISSN:1349-9092

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    Language:Japanese   Publisher:(一社)日本疫学会  

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  • Midlife and late-life diabetes and sarcopenia in a general older Japanese population: the Hisayama Study Reviewed International journal

    Nakamura K, Yoshida D, Honda T, Hata J, Shibata M, Hirakawa Y, Furuta Y, Kishimoto H, Ohara T, Chen S, Kitazono T, Nakashima Y, Ninomiya T.

    J Diabetes Investig   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jdi.13550

  • Emotional loneliness is associated with a risk of dementia in a general Japanese older population: the Hisayama Study Reviewed International journal

    Shibata M, Ohara T, Hosoi M, Hata J, Yoshida D, Hirabayashi N, Morisaki Y, Nakazawa T, Mihara A, Nagata T, Oishi E, Anno K, Sudo N, Ninomiya T.

    J Gerontol B Psychol Sci Soc Sci   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/geronb/gbaa196

  • Development of a risk prediction model for incident hypertension in Japanese individuals: the Hisayama Study Reviewed

    Oishi E, Hata J, Honda T, Sakata S, Chen S, Hirakawa Y, Yoshida D, Shibata M, Ohara T, Furuta Y, Kitazono T, Ninomiya T.

    Hypertens Res   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41440-021-00673-7

  • Pathologic diabetic nephropathy in autopsied diabetic cases with normoalbuminuria from a Japanese community-based study Reviewed International journal

    Sasaki T, Nakagawa K, Hata J, Hirakawa Y, Shibata M, Nakano T, Tsuboi N, Oda Y, Kitazono T, Yokoo T, Ninomiya T.

    Kidney Int Rep   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ekir.2021.09.007

  • Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Lancet   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0140-6736(21)01330-1

  • Serum NT-proBNP levels and histopathological myocardial fibrosis in autopsied cases from a Japanese community: the Hisayama Study Reviewed International journal

    Sasaki T, Izumaru K, Hata J, Sakata S, Oishi E, Nagata T, Tsuboi N, Oda Y, Kitazono T, Yokoo T, Ninomiya T.

    J Cardiol   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jjcc.2021.03.014

  • β-cell function and clinical outcome in nondiabetic patients with acute ischemic stroke Reviewed International journal

    Kiyohara T, Matsuo R, Hata J, Nakamura K, Wakisaka Y, Kamouchi M, Kitazono T, Ago T; FSR Investigators.

    Stroke   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.120.031392

  • 10-year trend of tooth loss and associated factors in a Japanese population-based longitudinal study. Reviewed International journal

    Michiko Furuta, Kenji Takeuchi, Toru Takeshita, Yukie Shibata, Shino Suma, Shinya Kageyama, Mikari Asakawa, Jun Hata, Daigo Yoshida, Yoshihiro Shimazaki, Toshiharu Ninomiya, Yoshihisa Yamashita

    BMJ open   11 ( 8 )   e048114   2021.8

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    OBJECTIVES: We examined the trend in the number of missing teeth in a Japanese community over a 10-year period and the potential associated explanatory factors. DESIGN: Prospective cohort study. SETTING: A population-based study conducted in 2007, 2012 and 2017 in Japan (Hisayama Study). PARTICIPANTS: Residents of a Japanese community aged 40-79 years undergoing dental examination in 2007 (n=2665), 2012 (n=2325) and 2017 (n=2285). OUTCOME MEASURES: The number of missing teeth, periodontal condition, dental caries experience, dental plaque index and oral health behaviours were evaluated each year. The longitudinal analysis of variation in these factors were assessed using mixed models. RESULTS: The age-adjusted and sex-adjusted mean number of missing teeth decreased with time (6.80 in 2007, 6.01 in 2012 and 4.99 in 2017). The mean clinical attachment level (CAL), prevalence of periodontitis and dental plaque index decreased over the study period, while dental caries experience slightly increased. The level of oral health behaviour increased over time. Poisson mixed models showed that changes in mean CAL and dental caries experience were positively associated with the change in the number of missing teeth over time. Linear mixed models showed that changes in dental plaque index and no regular dental visit were positively associated with changes in mean CAL. CONCLUSIONS: These findings suggest that a decreasing trend regarding the number of missing teeth in Japan might be associated with improvements in the periodontal condition due to changes in oral hygiene level and oral health behaviour.

    DOI: 10.1136/bmjopen-2020-048114

  • Comparison of the contributions of impaired beta cell function and insulin resistance to the development of type 2 diabetes in a Japanese community: the Hisayama Study Reviewed International journal

    Yoshinari M, Hirakawa Y, Hata J, Higashioka M, Honda T, Yoshida D, Mukai N, Nakamura U, Kitazono T, Ninomiya T.

    Diabetologia   2021.8

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    DOI: 10.1007/s00125-021-05459-7

  • Serum high-sensitivity C-reactive protein levels and the development of atrial fibrillation in a general Japanese population: the Hisayama Study Reviewed

    Yoshikawa T, Hata J, Sakata S, Nagata T, Hirakawa Y, Hirooka Y, Tsutsui H, Kitazono T, Ninomiya T.

    Circ J   2021.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-20-0751

  • Development of a dementia prediction model for primary care: the Hisayama Study Reviewed International journal

    Honda T, Ohara T, Yoshida D, Shibata M, Ishida Y, Furuta Y, Oishi E, Hirakawa Y, Sakata S, Hata J, Nakao T, Ninomiya T.

    Alzheimers Dement (Amst)   2021.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/dad2.12221

  • Current status of the certification of long-term care insurance among individuals with dementia in a Japanese community: the Hisayama Study Reviewed International journal

    Ohara T, Yoshida D, Hata J, Shibata M, Honda T, Furuta Y, Hirabayashi N, Kitazono T, Nakao T, Ninomiya T.

    Psychiatry Clin Neurosci   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/pcn.13204

  • Airflow limitation and tongue microbiota in community-dwelling elderly individuals Reviewed International journal

    Takeshita T, Matsumoto K, Furuta M, Fukuyama S, Takeuchi K, Ogata H, Asakawa M, Kageyama S, Hata J, Ninomiya T, Inoue H, Yamashita Y.

    ERJ Open Res   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1183/23120541.00616-2020

  • Prevalence and mortality of sarcopenia in a community-dwelling older Japanese population: the Hisayama Study Reviewed

    Nakamura K, Yoshida D, Honda T, Hata J, Shibata M, Hirakawa Y, Furuta Y, Kishimoto H, Ohara T, Kitazono T, Nakashima Y, Ninomiya T.

    J Epidemiol   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2188/jea.JE20190289

  • Dietary fiber intake and risk of type 2 diabetes in a general Japanese population: the Hisayama Study Reviewed International journal

    Kimura Y, Yoshida D, Hirakawa Y, Hata J, Honda T, Shibata M, Sakata S, Uchida K, Kitazono T, Ninomiya T.

    J Diabetes Investig   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jdi.13377

  • Urinary N-terminal pro-B-type natriuretic peptide as a biomarker for cardiovascular events in a general Japanese population: the Hisayama Study Reviewed

    Yamasaki K, Hata J, Ide T, Nagata T, Sakata S, Yoshida D, Honda T, Hirakawa Y, Nakano T, Kitazono T, Tsutsui H, Ninomiya T.

    Environ Health Prev Med   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12199-021-00970-0

  • Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Elife   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.7554/eLife.60060

  • Risk prediction for new-onset atrial fibrillation using the Minnesota code electrocardiography classification system Reviewed International journal

    Igarashi Y, Nochioka K, Sakata Y, Tamai T, Ohkouchi S, Irokawa T, Ogawa H, Hayashi H, Fujihashi T, Yamanaka S, Shiroto T, Miyata S, Hata J, Yamada S, Ninomiya T, Yasuda S, Kurosawa H, Shimokawa H.

    Int J Cardiol Heart Vasc   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijcha.2021.100762

  • High serum folate concentrations are associated with decreased risk of mortality among Japanese adults Reviewed International journal

    Chen S, Honda T, Hata J, Sakata S, Furuta Y, Yoshida D, Shibata M, Ohara T, Hirakawa Y, Oishi E, Kitazono T, Ninomiya T.

    J Nutr   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jn/nxaa382

  • The association of small dense low-density lipoprotein cholesterol and coronary heart disease in subjects at high cardiovascular risk Reviewed

    Higashioka M, Sakata S, Honda T, Hata J, Shibata M, Yoshida D, Goto K, Kitazono T, Osawa H, Ninomiya T.

    J Atheroscler Thromb   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5551/jat.55350

  • N-terminal pro-B-type natriuretic peptide and incident CKD Reviewed International journal

    Sasaki T, Oishi E, Nagata T, Sakata S, Chen S, Furuta Y, Honda T, Yoshida D, Hata J, Tsuboi N, Kitazono T, Yokoo T, Ninomiya T.

    Kidney Int Rep   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ekir.2021.01.006

  • Serum N-terminal pro-B-type natriuretic peptide as a predictor for future development of atrial fibrillation in a general population: the Hisayama Study Reviewed International journal

    Nagata T, Hata J, Sakata S, Oishi E, Honda T, Furuta Y, Ohara T, Yoshida D, Hirakawa Y, Shibata M, Ide T, Kitazono T, Tsutsui H, Ninomiya T.

    Int J Cardiol   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijcard.2020.06.018

  • Recent status of self-measured home blood pressure in the Japanese general population: a modern database on self-measured home blood pressure (MDAS) Reviewed

    Asayama K, Tabara Y, Oishi E, Sakata S, Hisamatsu T, Godai K, Kabayama M, Tatsumi Y, Hata J, Kikuya M, Kamide K, Miura K, Ninomiya T, Ohkubo T.

    Hypertens Res   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41440-020-0530-1

  • Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Lancet   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0140-6736(20)31859-6

  • Association between serum glycated albumin and risk of cardiovascular disease in a Japanese community: the Hisayama Study Reviewed International journal

    Mihara A, Ohara T, Hata J, Honda T, Chen S, Sakata S, Oishi E, Hirakawa Y, Nakao T, Kitazono T, Ninomiya T.

    Atherosclerosis   2020.10

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    DOI: 10.1016/j.atherosclerosis.2020.08.016

  • Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) Reviewed

    Ninomiya T, Nakaji S, Maeda T, Yamada M, Mimura M, Nakashima K, Mori T, Takebayashi M, Ohara T, Hata J, Kokubo Y, Uchida K, Taki Y, Kumagai S, Yonemoto K, Yoshida H, Muto K, Momozawa Y, Akiyama M, Kubo M, Ikeda M, Kanba S, Kiyohara Y; JPSC-AD Study Group.

    Environ Health Prev Med   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12199-020-00903-3

  • Influence of the accumulation of unhealthy eating habits on obesity in a general Japanese population: the Hisayama Study Reviewed International journal

    Ishida Y, Yoshida D, Honda T, Hirakawa Y, Shibata M, Sakata S, Furuta Y, Oishi E, Hata J, Kitazono T, Ninomiya T.

    Nutrients   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/nu12103160

  • Association of glucose tolerance status with pancreatic β- and α-cell mass in community-based autopsy samples of Japanese individuals: the Hisayama Study Reviewed International journal

    Inaishi J, Saisho Y, Hirakawa Y, Yoshida D, Hata J, Mukai N, Watanabe Y, Oda Y, Itoh H, Ninomiya T.

    J Diabetes Investig   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jdi.13232

  • Five-year incidence of myopic maculopathy in a general Japanese population: the Hisayama Study Reviewed International journal

    Ueda E, Yasuda M, Fujiwara K, Hashimoto S, Ohno-Matsui K, Hata J, Ishibashi T, Ninomiya T, Sonoda KH.

    JAMA Ophthalmol   2020.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1001/jamaophthalmol.2020.2211

  • Lifetime cumulative incidence of dementia in a community-dwelling elderly population in Japan Reviewed International journal

    Yoshida D, Ohara T, Hata J, Shibata M, Hirakawa Y, Honda T, Furuta Y, Oishi E, Sakata S, Kanba S, Kitazono T, Ninomiya T.

    Neurology   2020.8

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    DOI: 10.1212/WNL.0000000000009917

  • Elevated serum glycated albumin and glycated albumin : hemoglobin A1c ratio were associated with hippocampal atrophy in a general elderly population of Japanese: the Hisayama Study Reviewed International journal

    Ohara T, Furuta Y, Hirabayashi N, Hata J, Hirakawa Y, Honda T, Yoshida D, Shibata M, Kitazono T, Ninomiya T.

    J Diabetes Investig   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jdi.13220

  • 30-minute postload plasma glucose levels during an oral glucose tolerance test predict the risk of future type 2 diabetes: the Hisayama Study Reviewed International journal

    Hirakawa Y, Hata J, Yoshinari M, Higashioka M, Yoshida D, Shibata M, Honda T, Sakata S, Kato H, Teramoto T, Maki H, Nishimoto S, Kitazono T, Ninomiya T.

    BMJ Open Diabetes Res Care   2020.7

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    DOI: 10.1136/bmjdrc-2019-001156

  • Small dense low-density lipoprotein cholesterol and the risk of coronary heart disease in a Japanese community Reviewed

    Higashioka M, Sakata S, Honda T, Hata J, Yoshida D, Hirakawa Y, Shibata M, Goto K, Kitazono T, Osawa H, Ninomiya T.

    J Atheroscler Thromb   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5551/jat.51961

  • Serum uric acid levels and cardiovascular mortality in a general Japanese population: the Hisayama Study Reviewed

    Sakata S, Hata J, Honda T, Hirakawa Y, Oishi E, Shibata M, Yoshida D, Goto K, Kitazono T, Ninomiya T.

    Hypertens Res   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41440-019-0390-8

  • Repositioning of the global epicentre of non-optimal cholesterol Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Nature   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41586-020-2338-1

  • Serum homocysteine and risk of dementia in Japan Reviewed International journal

    Chen S, Honda T, Ohara T, Hata J, Hirakawa Y, Yoshida D, Shibata M, Sakata S, Oishi E, Furuta Y, Kitazono T, Ninomiya T.

    J Neurol Neurosurg Psychiatry   2020.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/jnnp-2019-322366

  • Association of albuminuria with white matter hyperintensities volume on brain magnetic resonance imaging in elderly Japanese: the Hisayama Study Reviewed

    Yamasaki K, Hata J, Furuta Y, Hirabayashi N, Ohara T, Yoshida D, Hirakawa Y, Nakano T, Kitazono T, Ninomiya T.

    Circ J   2020.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-19-1069

  • Ratios of serum eicosapentaenoic acid to arachidonic acid and docosahexaenoic acid to arachidonic acid were inversely associated with serum resistin levels: the Hisayama Study Reviewed International journal

    Higashioka M, Hirakawa Y, Kawamura R, Honda T, Hata J, Yoshida D, Takata Y, Kitazono T, Osawa H, Ninomiya T.

    J Diabetes Investig   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jdi.13129

  • Disrupted tongue microbiota and detection of nonindigenous bacteria on the day of allogeneic hematopoietic stem cell transplantation Reviewed International journal

    Oku S, Takeshita T, Futatsuki T, Kageyama S, Asakawa M, Mori Y, Miyamoto T, Hata J, Ninomiya T, Kashiwazaki H, Yamashita Y.

    PLoS Pathog   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.ppat.1008348

  • Genome-wide polygenic score and the risk of ischemic stroke in a prospective cohort: the Hisayama Study Reviewed International journal

    Hachiya T, Hata J, Hirakawa Y, Yoshida D, Furuta Y, Kitazono T, Shimizu A, Ninomiya T.

    Stroke   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.119.027520

  • National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Int J Epidemiol   2020.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ije/dyz099

  • Anticoagulation and risk of stroke recurrence in patients with embolic stroke of undetermined source having no potential source of embolism Reviewed International journal

    Sato N, Matsuo R, Kiyuna F, Nakamura K, Hata J, Wakisaka Y, Ago T, Kamouchi M, Kitazono T; the Fukuoka Stroke Registry Investigators.

    Cerebrovasc Dis   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000510773

  • Decline in handgrip strength from midlife to late-life is associated with dementia in a Japanese community: the Hisayama Study Reviewed

    Hatabe Y, Shibata M, Ohara T, Oishi E, Yoshida D, Honda T, Hata J, Kanba S, Kitazono T, Ninomiya T.

    J Epidemiol   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2188/jea.JE20180137

  • Long-term regular exercise and intraocular pressure: the Hisayama Study Reviewed International journal

    Fujiwara K, Yasuda M, Hata J, Yoshida D, Kishimoto H, Hashimoto S, Yoshitomi T, Ninomiya T, Sonoda KH.

    Graefes Arch Clin Exp Ophthalmol   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00417-019-04441-9

  • Serum elaidic acid concentration and risk of dementia: the Hisayama Study Reviewed International journal

    Honda T, Ohara T, Shinohara M, Hata J, Toh R, Yoshida D, Shibata M, Ishida T, Hirakawa Y, Irino Y, Sakata S, Uchida K, Kitazono T, Kanba S, Hirata KI, Ninomiya T.

    Neurology   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/WNL.0000000000008464

  • Serum lipopolysaccharide-binding protein levels and the incidence of cardiovascular disease in a general Japanese population: the Hisayama Study Reviewed International journal

    Asada M, Oishi E, Sakata S, Hata J, Yoshida D, Honda T, Furuta Y, Shibata M, Suzuki K, Watanabe H, Murayama N, Kitazono T, Yamaura K, Ninomiya T.

    J Am Heart Assoc   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/JAHA.119.013628

  • Association between axial length and myopic maculopathy: the Hisayama Study Reviewed International journal

    Hashimoto S, Yasuda M, Fujiwara K, Ueda E, Hata J, Hirakawa Y, Ninomiya T, Sonoda KH.

    Ophthalmol Retina   2019.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.oret.2019.04.023

  • Glucose tolerance levels and circumpapillary retinal nerve fiber layer thickness in a general Japanese population: the Hisayama Study Reviewed International journal

    Fujiwara K, Yasuda M, Hata J, Hirakawa Y, Hashimoto S, Ueda E, Iwase A, Araie M, Yoshitomi T, Ninomiya T, Sonoda KH.

    Am J Ophthalmol   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ajo.2019.03.031

  • NT-proBNP and risk of dementia in a general Japanese elderly population: the Hisayama Study Reviewed International journal

    Nagata T, Ohara T, Hata J, Sakata S, Furuta Y, Yoshida D, Honda T, Hirakawa Y, Ide T, Kanba S, Kitazono T, Tsutsui H, Ninomiya T.

    J Am Heart Assoc   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/JAHA.118.011652

  • Reduced estimated gfr and cardiac remodeling: a population-based autopsy study Reviewed International journal

    Izumaru K, Hata J, Nakano T, Nakashima Y, Nagata M, Fukuhara M, Oda Y, Kitazono T, Ninomiya T.

    Am J Kidney Dis   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1053/j.ajkd.2019.02.013

  • Association between genetic risk and development of type 2 diabetes in a general Japanese population: the Hisayama Study Reviewed International journal

    Inaishi J, Hirakawa Y, Horikoshi M, Akiyama M, Higashioka M, Yoshinari M, Hata J, Mukai N, Kamatani Y, Momozawa Y, Kubo M, Ninomiya T.

    J Clin Endocrinol Metab   2019.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/jc.2018-01782

  • Serum ethylamine levels as an indicator of l-theanine consumption and the risk of type 2 diabetes in a general Japanese population: the Hisayama Study Reviewed International journal

    Ninomiya T, Kanzaki N, Hirakawa Y, Yoshinari M, Higashioka M, Honda T, Shibata M, Sakata S, Yoshida D, Teramoto T, Takemoto S, Nishimoto S, Hata J, Kitazono T.

    Diabetes Care   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/dc18-2655

  • Trends in the prevalence of myopia and myopic maculopathy in a Japanese population: the Hisayama Study Reviewed International journal

    Ueda E, Yasuda M, Fujiwara K, Hashimoto S, Ohno-Matsui K, Hata J, Ishibashi T, Ninomiya T, Sonoda KH.

    Invest Ophthalmol Vis Sci   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1167/iovs.19-26580

  • Dairy consumption and risk of functional disability in an elderly Japanese population: the Hisayama Study Reviewed International journal

    Yoshida D, Ohara T, Hata J, Shibata M, Hirakawa Y, Honda T, Uchida K, Takasugi S, Kitazono T, Kiyohara Y, Ninomiya T.

    Am J Clin Nutr   2019.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ajcn/nqz040

  • Objectively measured sedentary time and diabetes mellitus in a general Japanese population: the Hisayama Study Reviewed International journal

    Honda T, Kishimoto H, Mukai N, Hata J, Yoshida D, Hirakawa Y, Shibata M, Ohara T, Kumagai S, Ninomiya T.

    J Diabetes Investig   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jdi.12968

  • Periodontitis is associated with chronic obstructive pulmonary disease Reviewed International journal

    Takeuchi K, Matsumoto K, Furuta M, Fukuyama S, Takeshita T, Ogata H, Suma S, Shibata Y, Shimazaki Y, Hata J, Ninomiya T, Nakanishi Y, Inoue H, Yamashita Y.

    J Dent Res   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/0022034519833630

  • Rising rural body-mass index is the main driver of the global obesity epidemic in adults Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Nature   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41586-019-1171-x

  • Poor glycemic control and posterior circulation ischemic stroke Reviewed International journal

    Kuroda J, Matsuo R, Yamaguchi Y, Sato N, Kamouchi M, Hata J, Wakisaka Y, Ago T, Kitazono T; Fukuoka Stroke Registry Investigators.

    Neurol Clin Pract   2019.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/CPJ.0000000000000608

  • Trends in the prevalence of airflow limitation in a general Japanese population: two serial cross-sectional surveys from the Hisayama Study Reviewed International journal

    Ogata H, Hirakawa Y, Matsumoto K, Hata J, Yoshida D, Fukuyama S, Inoue H, Kitazono T, Ninomiya T, Nakanishi Y.

    BMJ Open   2019.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/bmjopen-2018-023673

  • Longitudinal changes of physical activity and sedentary time in the middle-aged and older Japanese population: the Hisayama Study Reviewed International journal

    Yonemoto K, Honda T, Kishimoto H, Yoshida D, Hata J, Mukai N, Shibata M, Hirakawa Y, Ninomiya T, Kumagai S.

    J Phys Act Health   2019.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1123/jpah.2017-0701

  • Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study Reviewed International journal

    Larsson SC, Traylor M, Burgess S, Boncoraglio GB, Jern C, Michaëlsson K, Markus HS; MEGASTROKE project of the International Stroke Genetics Consortium.

    Neurology   2019.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/WNL.0000000000007001

  • Serum soluble triggering receptor expressed on myeloid cells 2 as a biomarker for incident dementia: the Hisayama Study Reviewed International journal

    Ohara T, Hata J, Tanaka M, Honda T, Yamakage H, Yoshida D, Inoue T, Hirakawa Y, Kusakabe T, Shibata M, Teraoka T, Kitazono T, Kanba S, Satoh-Asahara N, Ninomiya T.

    Ann Neurol   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ana.25385

  • Prevalence of adult epilepsy in a general Japanese population: the Hisayama Study Reviewed International journal

    Tanaka A, Hata J, Akamatsu N, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Ohara T, Mizuno T, Tsuji S, Kitazono T, Ninomiya T.

    Epilepsia Open   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/epi4.12295

  • Moyamoya disease susceptibility variant RNF213 p.R4810K increases the risk of ischemic stroke attributable to large-artery atherosclerosis Reviewed International journal

    Okazaki S, Morimoto T, Kamatani Y, Kamimura T, Kobayashi H, Harada K, Tomita T, Higashiyama A, Takahashi JC, Nakagawara J, Koga M, Toyoda K, Washida K, Saito S, Takahashi A, Hirata M, Matsuda K, Mochizuki H, Chong M, Paré G, O'Donnell M, Ago T, Hata J, Ninomiya T, Dichgans M, Debette S, Kubo M, Koizumi A, Ihara M.

    Circulation   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/CIRCULATIONAHA.118.038439

  • A potential novel pathological implication of serum soluble triggering receptor expressed on myeloid cell 2 in insulin resistance in a general Japanese population: the Hisayama Study Reviewed International journal

    Tanaka M, Honda T, Yamakage H, Hata J, Yoshida D, Hirakawa Y, Shibata M, Inoue T, Kusakabe T, Satoh-Asahara N, Ninomiya T.

    Diabetes Res Clin Pract   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.diabres.2018.10.007

  • GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes Reviewed International journal

    Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu L, Scholz M, Sargurupremraj M, Pitkänen N, Franzén O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O'Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, Völzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang J, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney LALM, Lind L, Raffield LM, Launer LJ, Holdt LM, Dörr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Melander O, Raitakari O, Franco OH, Rueda-Ochoa OL, Roussos P, Whincup PH, Amouyel P, Giral P, et al.

    Nat Commun   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-018-07340-5

  • Development and validation of modified risk prediction models for cardiovascular disease and its subtypes: the Hisayama Study Reviewed International journal

    Honda T, Yoshida D, Hata J, Hirakawa Y, Ishida Y, Shibata M, Sakata S, Kitazono T, Ninomiya T.

    Atherosclerosis   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.atherosclerosis.2018.10.014

  • Comparison of the periodontal condition in Korean and Japanese adults: a cross-sectional study Reviewed International journal

    Furuta M, Takeuchi K, Shimazaki Y, Takeshita T, Shibata Y, Hata J, Yoshida D, Park DY, Ninomiya T, Yamashita Y

    BMJ Open   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    Comparison of the periodontal condition in Korean and Japanese adults: a cross-sectional study

    DOI: 10.1136/bmjopen-2018-024332

  • Trends in the prevalence of type 2 diabetes and prediabetes in a Japanese community, 1988-2012: the Hisayama Study Reviewed International journal

    Mukai N, Hata J, Hirakawa Y, Ohara T, Yoshida D, Nakamura U, Kitazono T, Ninomiya T.

    Diabetol Int   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s13340-018-0380-0

  • Association between daily sleep duration and risk of dementia and mortality in a Japanese community Reviewed International journal

    Ohara T, Honda T, Hata J, Yoshida D, Mukai N, Hirakawa Y, Shibata M, Kishimoto H, Kitazono T, Kanba S, Ninomiya T.

    J Am Geriatr Soc   2018.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgs.15446

  • Association between the ratio of serum arachidonic acid to eicosapentaenoic acid and the presence of depressive symptoms in a general Japanese population: the Hisayama Study Reviewed International journal

    Shibata M, Ohara T, Yoshida D, Hata J, Mukai N, Kawano H, Kanba S, Kitazono T, Ninomiya T.

    J Affect Disord   2018.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jad.2018.05.004

  • Association of embolic sources with cause-specific functional outcomes among adults with cryptogenic stroke Reviewed International journal

    Kiyuna F, Sato N, Matsuo R, Kamouchi M, Hata J, Wakisaka Y, Kuroda J, Ago T, Kitazono T; Fukuoka Stroke Registry Investigators.

    JAMA Netw Open   2018.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1001/jamanetworkopen.2018.2953

  • Periodontal status and lung function decline in the community: the Hisayama Study Reviewed International journal

    Takeuchi K, Matsumoto K, Furuta M, Fukuyama S, Takeshita T, Ogata H, Suma S, Shibata Y, Shimazaki Y, Hata J, Ninomiya T, Nakanishi Y, Inoue H, Yamashita Y.

    Sci Rep   2018.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-31610-3

  • Tongue microbiota and oral health status in community-dwelling elderly adults Reviewed International journal

    Asakawa M, Takeshita T, Furuta M, Kageyama S, Takeuchi K, Hata J, Ninomiya T, Yamashita Y.

    mSphere   2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/mSphere.00332-18

  • Secular trends in the incidence, risk factors, and prognosis of transient ischemic attack in Japan: the Hisayama Study Reviewed International journal

    Furuta Y, Hata J, Mukai N, Hirakawa Y, Ago T, Kitazono T, Kiyohara Y, Ninomiya T.

    Atherosclerosis   2018.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.atherosclerosis.2018.04.010

  • Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community Reviewed International journal

    Yubi T, Hata J, Ohara T, Mukai N, Hirakawa Y, Yoshida D, Gotoh S, Hirabayashi N, Furuta Y, Ago T, Kitazono T, Kiyohara Y, Ninomiya T.

    Neurol Clin Pract   2018.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/CPJ.0000000000000464

  • Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Int J Epidemiol   2018.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ije/dyy016

  • Development and validation of a risk assessment tool for gastric cancer in a general Japanese population Reviewed International journal

    Iida M, Ikeda F, Hata J, Hirakawa Y, Ohara T, Mukai N, Yoshida D, Yonemoto K, Esaki M, Kitazono T, Kiyohara Y, Ninomiya T.

    Gastric Cancer   2018.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10120-017-0768-8

  • Patterns and levels of sedentary behavior and physical activity in a general Japanese population: the Hisayama Study Reviewed

    Chen T, Kishimoto H, Honda T, Hata J, Yoshida D, Mukai N, Shibata M, Ninomiya T, Kumagai S.

    J Epidemiol   2018.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2188/jea.JE20170012

  • Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes Reviewed International journal

    Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD Jr, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, den Hoed M, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jiménez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmäe K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, et al.

    Nat Genet   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41588-018-0058-3

  • Insulin resistance and clinical outcomes after acute ischemic stroke Reviewed International journal

    Ago T, Matsuo R, Hata J, Wakisaka Y, Kuroda J, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators.

    Neurology   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/WNL.0000000000005358

  • Clustering of risk factors and the risk of incident cardiovascular disease in asian and caucasian populations: results from the Asia Pacific Cohort Studies Collaboration Reviewed International journal

    Peters SAE, Wang X, Lam TH, Kim HC, Ho S, Ninomiya T, Knuiman M, Vaartjes I, Bots ML, Woodward M; Asia Pacific Cohort Studies Collaboration.

    BMJ Open   2018.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/bmjopen-2017-019335

  • Prevalence and risk factors for polypoidal choroidal vasculopathy in a general Japanese population: the Hisayama Study Reviewed International journal

    Fujiwara K, Yasuda M, Hata J, Oshima Y, Hashimoto S, Yoshitomi T, Kiyohara Y, Ishibashi T, Ninomiya T, Sonoda KH.

    Semin Ophthalmol   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/08820538.2018.1506483

  • Albuminuria increases the risks for both Alzheimer disease and vascular dementia in community-dwelling Japanese elderly: the Hisayama Study Reviewed International journal

    Takae K, Hata J, Ohara T, Yoshida D, Shibata M, Mukai N, Hirakawa Y, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T.

    J Am Heart Assoc   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/JAHA.117.006693

  • The ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cancer death in a Japanese community: the Hisayama Study Reviewed

    Nagata M, Hata J, Hirakawa Y, Mukai N, Yoshida D, Ohara T, Kishimoto H, Kawano H, Kitazono T, Kiyohara Y, Ninomiya T.

    J Epidemiol   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.je.2017.01.004

  • Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Lancet   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0140-6736(17)32129-3

  • Association between onset-to-door time and clinical outcomes after ischemic stroke Reviewed International journal

    Matsuo R, Yamaguchi Y, Matsushita T, Hata J, Kiyuna F, Fukuda K, Wakisaka Y, Kuroda J, Ago T, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators.

    Stroke   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.117.018132

  • Association of airflow limitation with carotid atherosclerosis in a Japanese community: the Hisayama Study Reviewed

    Kudo K, Hata J, Matsumoto K, Shundo Y, Fukuyama S, Inoue H, Kitazono T, Kiyohara Y, Ninomiya T, Nakanishi Y.

    Circ J   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-16-1305

  • Morning and evening blood pressures are associated with intima-media thickness in a general population: the Hisayama Study Reviewed

    Sakata S, Hata J, Fukuhara M, Yonemoto K, Mukai N, Yoshida D, Kishimoto H, Ohtsubo T, Kitazono T, Kiyohara Y, Ninomiya T.

    Circ J   2017.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-16-1306

  • Alternative measures of hyperglycemia and risk of Alzheimer's disease in the community: the Hisayama Study Reviewed International journal

    Mukai N, Ohara T, Hata J, Hirakawa Y, Yoshida D, Kishimoto H, Koga M, Nakamura U, Kitazono T, Kiyohara Y, Ninomiya T.

    J Clin Endocrinol Metab   2017.8

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    DOI: 10.1210/jc.2017-00439

  • Association between serum vitamin D and all-cause and cause-specific death in a general Japanese population: the Hisayama Study Reviewed

    Umehara K, Mukai N, Hata J, Hirakawa Y, Ohara T, Yoshida D, Kishimoto H, Kitazono T, Hoka S, Kiyohara Y, Ninomiya T.

    Circ J   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-16-0954

  • Left atrial size and long-term risk of recurrent stroke after acute ischemic stroke in patients with nonvalvular atrial fibrillation Reviewed International journal

    Ogata T, Matsuo R, Kiyuna F, Hata J, Ago T, Tsuboi Y, Kitazono T, Kamouchi M; FSR Investigators.

    J Am Heart Assoc   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/JAHA.117.006402

  • Day-to-day blood pressure variability and risk of dementia in a general Japanese elderly population: the Hisayama Study Reviewed International journal

    Oishi E, Ohara T, Sakata S, Fukuhara M, Hata J, Yoshida D, Shibata M, Ohtsubo T, Kitazono T, Kiyohara Y, Ninomiya T.

    Circulation   2017.8

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    DOI: 10.1161/CIRCULATIONAHA.116.025667

  • Prognostic value of variability in systolic blood pressure related to vascular events and premature death in type 2 diabetes mellitus: the ADVANCE-ON Study Reviewed International journal

    Ohkuma T, Woodward M, Jun M, Muntner P, Hata J, Colagiuri S, Harrap S, Mancia G, Poulter N, Williams B, Rothwell P, Chalmers J; ADVANCE Collaborative Group.

    Hypertension   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/HYPERTENSIONAHA.117.09359

  • Serum non-high-density lipoprotein cholesterol and risk of cardiovascular disease in community dwellers with chronic kidney disease: the Hisayama Study Reviewed

    Usui T, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Kitazono T, Kiyohara Y, Ninomiya T.

    J Atheroscler Thromb   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5551/jat.37044

  • Dietary protein intake and stroke risk in a general Japanese population: the Hisayama Study Reviewed International journal

    Ozawa M, Yoshida D, Hata J, Ohara T, Mukai N, Shibata M, Uchida K, Nagata M, Kitazono T, Kiyohara Y, Ninomiya T.

    Stroke   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.116.016059

  • Tooth loss and risk of dementia in the community: the Hisayama Study Reviewed International journal

    Takeuchi K, Ohara T, Furuta M, Takeshita T, Shibata Y, Hata J, Yoshida D, Yamashita Y, Ninomiya T.

    J Am Geriatr Soc   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgs.14791

  • Trends in dementia prevalence, incidence, and survival rate in a Japanese community Reviewed International journal

    Ohara T, Hata J, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y, Ninomiya T.

    Neurology   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/WNL.0000000000003932

  • Intracerebral hemorrhage location and outcome among INTERACT2 participants Reviewed International journal

    Delcourt C, Sato S, Zhang S, Sandset EC, Zheng D, Chen X, Hackett ML, Arima H, Hata J, Heeley E, Al-Shahi Salman R, Robinson T, Davies L, Lavados PM, Lindley RI, Stapf C, Chalmers J, Anderson CS; INTERACT2 Investigators.

    Neurology   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/WNL.0000000000003771

  • Genetic predisposition to ischemic stroke: a polygenic risk score Reviewed International journal

    Hachiya T, Kamatani Y, Takahashi A, Hata J, Furukawa R, Shiwa Y, Yamaji T, Hara M, Tanno K, Ohmomo H, Ono K, Takashima N, Matsuda K, Wakai K, Sawada N, Iwasaki M, Yamagishi K, Ago T, Ninomiya T, Fukushima A, Hozawa A, Minegishi N, Satoh M, Endo R, Sasaki M, Sakata K, Kobayashi S, Ogasawara K, Nakamura M, Hitomi J, Kita Y, Tanaka K, Iso H, Kitazono T, Kubo M, Tanaka H, Tsugane S, Kiyohara Y, Yamamoto M, Sobue K, Shimizu A.

    Stroke   2017.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.116.014506

  • Adverse influence of pre-stroke dementia on short-term functional outcomes in patients with acute ischemic stroke: the Fukuoka Stroke Registry Reviewed International journal

    Wakisaka Y, Matsuo R, Hata J, Kuroda J, Kitazono T, Kamouchi M, Ago T; Fukuoka Stroke Registry Investigators.

    Cerebrovasc Dis   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000453625

  • Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Lancet   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0140-6736(16)31919-5

  • Associations with health-related quality of life after intracerebral haemorrhage: pooled analysis of INTERACT studies Reviewed International journal

    Delcourt C, Zheng D, Chen X, Hackett M, Arima H, Hata J, Heeley E, Al-Shahi Salman R, Woodward M, Huang Y, Robinson T, Lavados PM, Lindley RI, Stapf C, Davies L, Chalmers J, Anderson CS, Sato S; INTERACT Investigators.

    J Neurol Neurosurg Psychiatry   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/jnnp-2016-314414

  • Combination of helicobacter pylori antibody and serum pepsinogen as a good predictive tool of gastric cancer incidence: 20-year prospective data from the Hisayama Study Reviewed

    Ikeda F, Shikata K, Hata J, Fukuhara M, Hirakawa Y, Ohara T, Mukai N, Nagata M, Yoshida D, Yonemoto K, Esaki M, Kitazono T, Kiyohara Y, Ninomiya T.

    J Epidemiol   2016.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2188/jea.JE20150258

  • The development of a risk score for incident atrial fibrillation in Japanese general population cohorts: a collaborative meta-analysis Reviewed International journal

    Kokubo Yoshihiro, Imano Hironori, Hata Jun, Murakoshi Nobuyuki, Aizawa Yoshifusa, Iso Hiroyasu, Ninomiya Toshiharu, Nakamura Fumiaki, Miyamoto Yoshihiro, Okamura Tomonori, Tomita Hirofumi, Okumura Ken

    CIRCULATION   134   2016.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-17-0277

  • PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice Reviewed International journal

    Torisu K, Zhang X, Nonaka M, Kaji T, Tsuchimoto D, Kajitani K, Sakumi K, Torisu T, Chida K, Sueishi K, Kubo M, Hata J, Kitazono T, Kiyohara Y, Nakabeppu Y.

    Genes Cells   2016.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/gtc.12402

  • Association between diabetes and hippocampal atrophy in elderly Japanese: the Hisayama Study Reviewed International journal

    Hirabayashi N, Hata J, Ohara T, Mukai N, Nagata M, Shibata M, Gotoh S, Furuta Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Kiyohara Y, Ninomiya T.

    Diabetes Care   2016.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/dc15-2800

  • Prognostic significance of hyponatremia in acute intracerebral hemorrhage: pooled analysis of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial Studies Reviewed International journal

    Carcel C, Sato S, Zheng D, Heeley E, Arima H, Yang J, Wu G, Chen G, Zhang S, Delcourt C, Lavados P, Robinson T, Lindley RI, Wang X, Chalmers J, Anderson CS; Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial 2 Investigators.

    Crit Care Med   2016.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0000000000001628

  • A century of trends in adult human height Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Elife   2016.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.7554/eLife.13410

  • Serum uric acid as a risk factor for chronic kidney disease in a Japanese community: the Hisayama Study Reviewed

    Takae K, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T.

    Circ J   2016.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-16-0030

  • Estimated GFR and the effect of intensive blood pressure lowering after acute intracerebral hemorrhage Reviewed International journal

    Zheng D, Sato S, Arima H, Heeley E, Delcourt C, Cao Y, Chalmers J, Anderson CS; INTERACT2 Investigators.

    Am J Kidney Dis   2016.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1053/j.ajkd.2016.01.020

  • Foveal and macular thickness in a Japanese population: the Hisayama Study Reviewed International journal

    Hashimoto S, Yasuda M, Ninomiya T, Hata J, Yoshida D, Tahara-Asakuma T, Hirakawa Y, Arakawa S, Fujiwara K, Kiyohara Y, Ishibashi T.

    Ophthalmic Epidemiol   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3109/09286586.2015.1136651

  • Plasma C-reactive protein and clinical outcomes after acute ischemic stroke: a prospective observational study Reviewed International journal

    Matsuo R, Ago T, Hata J, Wakisaka Y, Kuroda J, Kuwashiro T, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators.

    PLoS One   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0156790

  • Elevated 2-hour post-load glucose levels and longer duration of diabetes are risk factors for hippocampal atrophy in elderly Japanese: the Hisayama Study Reviewed International journal

    Naoki Hirabayashi, Jun Hata, Tomoyuki Ohara, Naoko Mukai, Masaharu Nagata, Mao Shibata, Seiji Goto, Yoshihiko Furuta, Fumio Yamashita, Kazufumi Yoshihara, Takanari Kitazono, Nobuyuki Sudo, Yutaka Kiyohara, Toshiharu Ninomiya

    DIABETES   65   A361 - A361   2016.6

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    DOI: 10.2337/dc15-2800

  • Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Lancet   2016.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0140-6736(16)00618-8

  • The long-term association between physical activity and risk of dementia in the community: the Hisayama Study Reviewed International journal

    Kishimoto H, Ohara T, Hata J, Ninomiya T, Yoshida D, Mukai N, Nagata M, Ikeda F, Fukuhara M, Kumagai S, Kanba S, Kitazono T, Kiyohara Y.

    Eur J Epidemiol   2016.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10654-016-0125-y

  • Low ambient temperature and intracerebral hemorrhage: the INTERACT2 study Reviewed International journal

    Zheng D, Arima H, Sato S, Gasparrini A, Heeley E, Delcourt C, Lo S, Huang Y, Wang J, Stapf C, Robinson T, Lavados P, Chalmers J, Anderson CS; INTERACT2 Investigators.

    PLoS One   2016.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0149040

  • Determinants and prognostic significance of hematoma sedimentation levels in acute intracerebral hemorrhage Reviewed International journal

    Sato S, Delcourt C, Zhang S, Arima H, Heeley E, Zheng D, Al-Shahi Salman R, Stapf C, Tzourio C, Robinson T, Lindley RI, Chalmers J, Anderson CS; INTERACT2 Investigators.

    Cerebrovasc Dis   2016.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000442532

  • Adjustment of cell-type composition minimizes systematic bias in blood dna methylation profiles derived by DNA collection protocols Reviewed International journal

    Shiwa Y, Hachiya T, Furukawa R, Ohmomo H, Ono K, Kudo H, Hata J, Hozawa A, Iwasaki M, Matsuda K, Minegishi N, Satoh M, Tanno K, Yamaji T, Wakai K, Hitomi J, Kiyohara Y, Kubo M, Tanaka H, Tsugane S, Yamamoto M, Sobue K, Shimizu A.

    PLoS One   2016.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0147519

  • Influence of statin pretreatment on initial neurological severity and short-term functional outcome in acute ischemic stroke patients: the Fukuoka Stroke Registry Reviewed International journal

    Ishikawa H, Wakisaka Y, Matsuo R, Makihara N, Hata J, Kuroda J, Ago T, Kitayama J, Nakane H, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators.

    Cerebrovasc Dis   2016.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000447718

  • Causes of ischemic stroke in patients with non-valvular atrial fibrillation Reviewed International journal

    Nakamura A, Kuroda J, Ago T, Hata J, Matsuo R, Arakawa S, Kuwashiro T, Yasaka M, Okada Y, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators.

    Cerebrovasc Dis   2016.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000445723

  • Insulin resistance is a risk factor for increased intraocular pressure: the Hisayama Study Reviewed International journal

    Fujiwara K, Yasuda M, Ninomiya T, Hata J, Hashimoto S, Yoshitomi T, Kiyohara Y, Ishibashi T.

    Invest Ophthalmol Vis Sci   2015.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1167/iovs.15-16766

  • Higher mortality in patients with right hemispheric intracerebral haemorrhage: INTERACT1 and 2 Reviewed International journal

    Sato S, Heeley E, Arima H, Delcourt C, Hirakawa Y, Pamidimukkala V, Li Z, Tao Q, Xu Y, Hennerici MG, Robinson T, Tzourio C, Lindley RI, Chalmers J, Anderson CS; INTERACT Investigators, Anderson CS, Huang Y, Wang JG, Arima H, Neal B, Peng B, Heeley E, Skulina C, Parsons MW, Kim JS, Tao QL, Li YC, Jiang JD, Tai LW, Zhang LJ, Xu E, Cheng Y, Heritier S, Morgenstern LB, Chalmers J.

    J Neurol Neurosurg Psychiatry   2015.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/jnnp-2014-309870

  • Midlife and late-life smoking and risk of dementia in the community: the Hisayama Study Reviewed International journal

    Ohara T, Ninomiya T, Hata J, Ozawa M, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y.

    J Am Geriatr Soc   2015.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgs.13794

  • Hematocrit and the risk of cardiovascular disease in a Japanese community: the Hisayama Study Reviewed International journal

    Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Ago T, Kitazono T, Kiyohara Y.

    Atherosclerosis   2015.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.atherosclerosis.2015.07.014

  • Day-by-day blood pressure variability and functional outcome after acute ischemic stroke: Fukuoka Stroke Registry Reviewed International journal

    Fukuda K, Kai H, Kamouchi M, Hata J, Ago T, Nakane H, Imaizumi T, Kitazono T; FSR Investigators.

    Stroke   2015.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.115.009076

  • Covariate-adjusted measures of discrimination for survival data Reviewed International journal

    White IR, Rapsomaniki E; Emerging Risk Factors Collaboration.

    Biom J   2015.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/bimj.201400061

  • Association of hemoglobin A1c and glycated albumin with carotid atherosclerosis in community-dwelling Japanese subjects: the Hisayama Study Reviewed International journal

    Mukai N, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y.

    Cardiovasc Diabetol   2015.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12933-015-0247-7

  • Sex differences in short-term outcomes after acute ischemic stroke: the Fukuoka Stroke Registry Reviewed International journal

    Irie F, Kamouchi M, Hata J, Matsuo R, Wakisaka Y, Kuroda J, Ago T, Kitazono T; FSR Investigators.

    Stroke   2015.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.114.006739

  • Optimal achieved blood pressure in acute intracerebral hemorrhage: INTERACT2 Reviewed International journal

    Arima H, Heeley E, Delcourt C, Hirakawa Y, Wang X, Woodward M, Robinson T, Stapf C, Parsons M, Lavados PM, Huang Y, Wang J, Chalmers J, Anderson CS; INTERACT2 Investigators.

    Neurology   2015.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/WNL.0000000000001205

  • Angiotensin I-converting enzyme gene polymorphism enhances the effect of hypercholesterolemia on the risk of coronary heart disease in a general Japanese population: the Hisayama Study Reviewed

    Kondo H, Ninomiya T, Hata J, Hirakawa Y, Yonemoto K, Arima H, Nagata M, Tsuruya K, Kitazono T, Kiyohara Y.

    J Atheroscler Thromb   2015.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5551/jat.24166

  • Effects of hydrochlorothiazide on oxidative stress and pulse pressure in hypertensive patients with chronic stroke: the EMINENT Study Reviewed

    Nakane H, Kamouchi M, Hata J, Ibayashi S, Kusuda K, Omae T, Nagao T, Ago T, Kitazono T; EMINENT Study Investigators.

    Intern Med   2015.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.54.2631

  • Off-hour admission and outcomes in patients with acute intracerebral hemorrhage in the INTERACT2 trial Reviewed International journal

    Sato S, Arima H, Heeley E, Hirakawa Y, Delcourt C, Lindley RI, Robinson T, Huang Y, Morgenstern L, Stapf C, Wang J, Chalmers J, Anderson CS; INTERACT2 Investigators.

    Cerebrovasc Dis   2015.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000434690

  • Thrombolytic therapy with intravenous recombinant tissue plasminogen activator in Japanese older patients with acute ischemic stroke: Fukuoka Stroke Registry Reviewed International journal

    Matsuo R, Kamouchi M, Ago T, Hata J, Shono Y, Kuroda J, Wakisaka Y, Sugimori H, Kitazono T; FSR investigators.

    Geriatr Gerontol Int   2014.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ggi.12205

  • Intravenous thrombolysis with recombinant tissue plasminogen activator for ischemic stroke patients over 80 years old: the Fukuoka Stroke Registry Reviewed International journal

    Matsuo R, Kamouchi M, Fukuda H, Hata J, Wakisaka Y, Kuroda J, Ago T, Kitazono T; FSR Investigators.

    PLoS One   2014.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0110444

  • Significance of plasma adiponectin for diagnosis, neurological severity and functional outcome in ischemic stroke: Research for Biomarkers in Ischemic Stroke (REBIOS) Reviewed International journal

    Kuwashiro T, Ago T, Kamouchi M, Matsuo R, Hata J, Kuroda J, Fukuda K, Sugimori H, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T.

    Metabolism   2014.9

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    DOI: 10.1016/j.metabol.2014.04.012

  • Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment Reviewed International journal

    Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration.

    Lancet Diabetes Endocrinol   2014.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S2213-8587(14)70102-0

  • Impact of the 1425G/A polymorphism of PRKCH on the recurrence of ischemic stroke: Fukuoka Stroke Registry Reviewed International journal

    Matsuo R, Ago T, Hata J, Kuroda J, Wakisaka Y, Sugimori H, Kitazono T, Kamouchi M; FSR Investigators.

    J Stroke Cerebrovasc Dis   2014.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jstrokecerebrovasdis.2013.11.011

  • Gastrointestinal bleeding in acute ischemic stroke: recent trends from the Fukuoka Stroke Registry Reviewed International journal

    Ogata T, Kamouchi M, Matsuo R, Hata J, Kuroda J, Ago T, Sugimori H, Inoue T, Kitazono T; Fukuoka Stroke Registry.

    Cerebrovasc Dis Extra   2014.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000365245

  • Midlife and late-life handgrip strength and risk of cause-specific death in a general Japanese population: the Hisayama Study Reviewed International journal

    Kishimoto H, Hata J, Ninomiya T, Nemeth H, Hirakawa Y, Yoshida D, Kumagai S, Kitazono T, Kiyohara Y.

    J Epidemiol Community Health   2014.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/jech-2013-203611

  • Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama Study Reviewed International journal

    Ozawa M, Ohara T, Ninomiya T, Hata J, Yoshida D, Mukai N, Nagata M, Uchida K, Shirota T, Kitazono T, Kiyohara Y.

    J Am Geriatr Soc   2014.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgs.12887

  • Plasma S100A12 is associated with functional outcome after ischemic stroke: Research for Biomarkers in Ischemic Stroke Reviewed International journal

    Wakisaka Y, Ago T, Kamouchi M, Kuroda J, Matsuo R, Hata J, Gotoh S, Isomura T, Awano H, Suzuki K, Fukuda K, Okada Y, Kiyohara Y, Ooboshi H, Kitazono T; REBIOS Investigators.

    J Neurol Sci   2014.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jns.2014.02.031

  • Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population: the Hisayama Study Reviewed International journal

    Imamura T, Doi Y, Ninomiya T, Hata J, Nagata M, Ikeda F, Mukai N, Hirakawa Y, Yoshida D, Fukuhara M, Kitazono T, Kiyohara Y.

    Atherosclerosis   2014.4

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    DOI: 10.1016/j.atherosclerosis.2014.01.005

  • Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1.8 million participants Reviewed International journal

    Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (BMI Mediated Effects), Lu Y, Hajifathalian K, Ezzati M, Woodward M, Rimm EB, Danaei G.

    Lancet   2014.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0140-6736(13)61836-X

  • Glycated hemoglobin measurement and prediction of cardiovascular disease Reviewed International journal

    Emerging Risk Factors Collaboration, Di Angelantonio E, Gao P, Khan H, Butterworth AS, Wormser D, Kaptoge S, Kondapally Seshasai SR, Thompson A, Sarwar N, Willeit P, Ridker PM, Barr EL, Khaw KT, Psaty BM, Brenner H, Balkau B, Dekker JM, Lawlor DA, Daimon M, Willeit J, Njølstad I, Nissinen A, Brunner EJ, Kuller LH, Price JF, Sundström J, Knuiman MW, Feskens EJ, Verschuren WM, Wald N, Bakker SJ, Whincup PH, Ford I, Goldbourt U, Gómez-de-la-Cámara A, Gallacher J, Simons LA, Rosengren A, Sutherland SE, Björkelund C, Blazer DG, Wassertheil-Smoller S, Onat A, Marín Ibañez A, Casiglia E, Jukema JW, Simpson LM, Giampaoli S, Nordestgaard BG, Selmer R, Wennberg P, Kauhanen J, Salonen JT, Dankner R, Barrett-Connor E, Kavousi M, Gudnason V, Evans D, Wallace RB, Cushman M, D'Agostino RB Sr, Umans JG, Kiyohara Y, Nakagawa H, Sato S, Gillum RF, Folsom AR, van der Schouw YT, Moons KG, Griffin SJ, Sattar N, Wareham NJ, Selvin E, Thompson SG, Danesh J.

    JAMA   2014.3

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    DOI: 10.1001/jama.2014.1873

  • Trends in the prevalence of type 2 diabetes and prediabetes in community-dwelling Japanese subjects: the Hisayama Study Reviewed International journal

    Mukai N, Doi Y, Ninomiya T, Hirakawa Y, Nagata M, Yoshida D, Hata J, Fukuhara M, Nakamura U, Kitazono T, Kiyohara Y.

    J Diabetes Investig   2014.3

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    DOI: 10.1111/jdi.12136

  • ABCD3 and ABCD3-I scores are superior to ABCD2 score in the prediction of short- and long-term risks of stroke after transient ischemic attack Reviewed International journal

    Kiyohara T, Kamouchi M, Kumai Y, Ninomiya T, Hata J, Yoshimura S, Ago T, Okada Y, Kitazono T; Fukuoka Stroke Registry Investigators.

    Stroke   2014.2

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    DOI: 10.1161/STROKEAHA.113.003077

  • Thresholds of various glycemic measures for diagnosing diabetes based on prevalence of retinopathy in community-dwelling Japanese subjects: the Hisayama Study Reviewed International journal

    Mukai N, Yasuda M, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y.

    Cardiovasc Diabetol   2014.2

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    DOI: 10.1186/1475-2840-13-45

  • A low ankle brachial index is associated with an increased risk of cardiovascular disease: the Hisayama Study Reviewed

    Kojima I, Ninomiya T, Hata J, Fukuhara M, Hirakawa Y, Mukai N, Yoshida D, Kitazono T, Kiyohara Y.

    J Atheroscler Thromb   2014.1

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    DOI: 10.5551/jat.22608

  • Trends in the incidence and survival of intracerebral hemorrhage by its location in a Japanese community Reviewed

    Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Shikata K, Kamouchi M, Kitazono T, Kiyohara Y.

    Circ J   2014.1

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    DOI: 10.1253/circj.cj-13-0811

  • High blood pressure after acute ischemic stroke is associated with poor clinical outcomes: Fukuoka Stroke Registry Reviewed International journal

    Ishitsuka K, Kamouchi M, Hata J, Fukuda K, Matsuo R, Kuroda J, Ago T, Kuwashiro T, Sugimori H, Nakane H, Kitazono T; FSR Investigators.

    Hypertension   2014.1

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    DOI: 10.1161/HYPERTENSIONAHA.113.02189

  • Statins and the risks of stroke recurrence and death after ischemic stroke: the Fukuoka Stroke Registry Reviewed International journal

    Makihara N, Kamouchi M, Hata J, Matsuo R, Ago T, Kuroda J, Kuwashiro T, Sugimori H, Kitazono T; Fukuoka Stroke Registry Investigators.

    Atherosclerosis   2013.12

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    DOI: 10.1016/j.atherosclerosis.2013.09.017

  • Magnesium intake decreases type 2 diabetes risk through the improvement of insulin resistance and inflammation: the Hisayama Study Reviewed International journal

    Hata A, Doi Y, Ninomiya T, Mukai N, Hirakawa Y, Hata J, Ozawa M, Uchida K, Shirota T, Kitazono T, Kiyohara Y.

    Diabet Med   2013.12

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    DOI: 10.1111/dme.12250

  • Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: the Hisayama Study Reviewed International journal

    Ninomiya T, Nagata M, Hata J, Hirakawa Y, Ozawa M, Yoshida D, Ohara T, Kishimoto H, Mukai N, Fukuhara M, Kitazono T, Kiyohara Y.

    Atherosclerosis   2013.12

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    DOI: 10.1016/j.atherosclerosis.2013.09.023

  • Intensity of anticoagulation and clinical outcomes in acute cardioembolic stroke: the Fukuoka Stroke Registry Reviewed International journal

    Nakamura A, Ago T, Kamouchi M, Hata J, Matsuo R, Kuroda J, Kuwashiro T, Sugimori H, Kitazono T; Fukuoka Stroke Registry Investigators.

    Stroke   2013.11

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    DOI: 10.1161/STROKEAHA.113.002523

  • Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general Japanese population: the Hisayama Study Reviewed International journal

    Ikeda F, Doi Y, Ninomiya T, Hirakawa Y, Mukai N, Hata J, Shikata K, Yoshida D, Matsumoto T, Kitazono T, Kiyohara Y.

    Cardiovasc Diabetol   2013.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1475-2840-12-164

  • Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: a cross-sectional study Reviewed International journal

    Sekita A, Arima H, Ninomiya T, Ohara T, Doi Y, Hirakawa Y, Fukuhara M, Hata J, Yonemoto K, Ga Y, Kitazono T, Kanba S, Kiyohara Y.

    BMC Public Health   2013.9

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    DOI: 10.1186/1471-2458-13-862

  • Temporal trends in sudden unexpected death in a general population: the Hisayama Study Reviewed International journal

    Nagata M, Ninomiya T, Doi Y, Hata J, Ikeda F, Mukai N, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y.

    Am Heart J   2013.6

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    DOI: 10.1016/j.ahj.2013.02.028

  • Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage Reviewed International journal

    Anderson CS, Heeley E, Huang Y, Wang J, Stapf C, Delcourt C, Lindley R, Robinson T, Lavados P, Neal B, Hata J, Arima H, Parsons M, Li Y, Wang J, Heritier S, Li Q, Woodward M, Simes RJ, Davis SM, Chalmers J; INTERACT2 Investigators.

    N Engl J Med   2013.6

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    DOI: 10.1056/NEJMoa1214609

  • White-coat and masked hypertension are associated with carotid atherosclerosis in a general population: the Hisayama Study Reviewed International journal

    Fukuhara M, Arima H, Ninomiya T, Hata J, Hirakawa Y, Doi Y, Yonemoto K, Mukai N, Nagata M, Ikeda F, Matsumura K, Kitazono T, Kiyohara Y.

    Stroke   2013.6

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    DOI: 10.1161/STROKEAHA.111.000704

  • Clinical significance of plasma vegf value in ischemic stroke: Research for Biomarkers in Ischemic Stroke (REBIOS) Study Reviewed International journal

    Matsuo R, Ago T, Kamouchi M, Kuroda J, Kuwashiro T, Hata J, Sugimori H, Fukuda K, Gotoh S, Makihara N, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T.

    BMC Neurol   2013.4

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    DOI: 10.1186/1471-2377-13-32

  • The global cardiovascular risk transition: associations of four metabolic risk factors with national income, urbanization, and western diet in 1980 and 2008 Reviewed International journal

    Danaei G, Singh GM, Paciorek CJ, Lin JK, Cowan MJ, Finucane MM, Farzadfar F, Stevens GA, Riley LM, Lu Y, Rao M, Ezzati M; Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group.

    Circulation   2013.4

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    DOI: 10.1161/CIRCULATIONAHA.113.001470

  • Brachial-ankle pulse wave velocity predicts the development of cardiovascular disease in a general Japanese population: the Hisayama Study Reviewed International journal

    Ninomiya T, Kojima I, Doi Y, Fukuhara M, Hirakawa Y, Hata J, Kitazono T, Kiyohara Y.

    J Hypertens   2013.3

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    DOI: 10.1097/HJH.0b013e32835c5c23

  • Angiopoietin-like protein 2 and risk of type 2 diabetes in a general Japanese population: the Hisayama Study Reviewed International journal

    Doi Y, Ninomiya T, Hirakawa Y, Takahashi O, Mukai N, Hata J, Iwase M, Kitazono T, Oike Y, Kiyohara Y.

    Diabetes Care   2013.1

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    DOI: 10.2337/dc12-0166

  • Angiopoietin-like protein 2 is associated with chronic kidney disease in a general Japanese population: the Hisayama Study Reviewed

    Usui T, Ninomiya T, Nagata M, Takahashi O, Doi Y, Hata J, Fukuhara M, Kitazono T, Oike Y, Kiyohara Y.

    Circ J   2013.1

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    DOI: 10.1253/circj.cj-12-1548

  • Prediction of kidney-related outcomes in patients with type 2 diabetes Reviewed International journal

    Jardine MJ, Hata J, Woodward M, Perkovic V, Ninomiya T, Arima H, Zoungas S, Cass A, Patel A, Marre M, Mancia G, Mogensen CE, Poulter N, Chalmers J; ADVANCE Collaborative Group.

    Am J Kidney Dis   2012.11

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    DOI: 10.1053/j.ajkd.2012.04.025

  • Association between glucose tolerance level and cancer death in a general Japanese population: the Hisayama Study Reviewed International journal

    Hirakawa Y, Ninomiya T, Mukai N, Doi Y, Hata J, Fukuhara M, Iwase M, Kitazono T, Kiyohara Y.

    Am J Epidemiol   2012.11

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    DOI: 10.1093/aje/kws178

  • Resting heart rate and the risk of microvascular complications in patients with type 2 diabetes mellitus Reviewed International journal

    Hillis GS, Hata J, Woodward M, Perkovic V, Arima H, Chow CK, Zoungas S, Patel A, Poulter NR, Mancia G, Williams B, Chalmers J.

    J Am Heart Assoc   2012.10

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    DOI: 10.1161/JAHA.112.002832

  • Self-reported dietary intake of potassium, calcium, and magnesium and risk of dementia in the Japanese: the Hisayama Study Reviewed International journal

    Ozawa M, Ninomiya T, Ohara T, Hirakawa Y, Doi Y, Hata J, Uchida K, Shirota T, Kitazono T, Kiyohara Y.

    J Am Geriatr Soc   2012.8

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    DOI: 10.1111/j.1532-5415.2012.04061.x

  • Smoking cessation improves mortality in Japanese men: the Hisayama Study Reviewed International journal

    Ikeda F, Ninomiya T, Doi Y, Hata J, Fukuhara M, Matsumoto T, Kiyohara Y.

    Tob Control   2012.7

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    DOI: 10.1136/tc.2010.039362

  • Proteinuria and clinical outcomes after ischemic stroke Reviewed International journal

    Kumai Y, Kamouchi M, Hata J, Ago T, Kitayama J, Nakane H, Sugimori H, Kitazono T; FSR Investigators.

    Neurology   2012.6

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    DOI: 10.1212/WNL.0b013e318259e110

  • Optimal cutoff value of the serum pepsinogen level for prediction of gastric cancer incidence: the Hisayama Study Reviewed International journal

    Shikata K, Ninomiya T, Yonemoto K, Ikeda F, Hata J, Doi Y, Fukuhara M, Matsumoto T, Iida M, Kitazono T, Kiyohara Y.

    Scand J Gastroenterol   2012.6

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    DOI: 10.3109/00365521.2012.658855

  • Impact of lower range of prehypertension on cardiovascular events in a general population: the Hisayama Study Reviewed International journal

    Fukuhara M, Arima H, Ninomiya T, Hata J, Yonemoto K, Doi Y, Hirakawa Y, Matsumura K, Kitazono T, Kiyohara Y.

    J Hypertens   2012.5

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    DOI: 10.1097/HJH.0b013e328351d380

  • Dietary vitamin a intake and incidence of gastric cancer in a general Japanese population: the Hisayama Study Reviewed International journal

    Miyazaki M, Doi Y, Ikeda F, Ninomiya T, Hata J, Uchida K, Shirota T, Matsumoto T, Iida M, Kiyohara Y.

    Gastric Cancer   2012.4

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    DOI: 10.1007/s10120-011-0092-7

  • White blood cell count and risk of gastric cancer incidence in a general Japanese population: the Hisayama Study Reviewed International journal

    Iida M, Ikeda F, Ninomiya T, Yonemoto K, Doi Y, Hata J, Matsumoto T, Iida M, Kiyohara Y.

    Am J Epidemiol   2012.3

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    DOI: 10.1093/aje/kwr345

  • The factors associated with a functional outcome after ischemic stroke in diabetic patients: the Fukuoka Stroke Registry Reviewed International journal

    Kuwashiro T, Kamouchi M, Ago T, Hata J, Sugimori H, Kitazono T.

    J Neurol Sci   2012.2

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    DOI: 10.1016/j.jns.2011.09.012

  • Insulin resistance and the development of cardiovascular disease in a Japanese community: the Hisayama Study Reviewed

    Gotoh S, Doi Y, Hata J, Ninomiya T, Mukai N, Fukuhara M, Kamouchi M, Kitazono T, Kiyohara Y.

    J Atheroscler Thromb   2012.1

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    DOI: 10.5551/jat.13698

  • Cut-off values of fasting and post-load plasma glucose and HbA1c for predicting type 2 diabetes in community-dwelling Japanese subjects: the Hisayama Study Reviewed International journal

    Mukai N, Doi Y, Ninomiya T, Hata J, Hirakawa Y, Fukuhara M, Iwase M, Kiyohara Y.

    Diabet Med   2012.1

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    DOI: 10.1111/j.1464-5491.2011.03378.x

  • Two risk score models for predicting incident type 2 diabetes in Japan Reviewed International journal

    Doi Y, Ninomiya T, Hata J, Hirakawa Y, Mukai N, Iwase M, Kiyohara Y.

    Diabet Med   2012.1

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    DOI: 10.1111/j.1464-5491.2011.03376.x

  • Prevalence and causes of functional disability in an elderly general population of Japanese: the Hisayama Study Reviewed

    Yoshida D, Ninomiya T, Doi Y, Hata J, Fukuhara M, Ikeda F, Mukai N, Kiyohara Y.

    J Epidemiol   2012.1

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    DOI: 10.2188/jea.je20110083

  • N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in a Japanese community: the Hisayama Study Reviewed International journal

    Doi Y, Ninomiya T, Hata J, Hirakawa Y, Mukai N, Ikeda F, Fukuhara M, Iwase M, Kiyohara Y.

    Arterioscler Thromb Vasc Biol   2011.12

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    DOI: 10.1161/ATVBAHA.111.223669

  • Prestroke glycemic control is associated with the functional outcome in acute ischemic stroke: the Fukuoka Stroke Registry Reviewed International journal

    Kamouchi M, Matsuki T, Hata J, Kuwashiro T, Ago T, Sambongi Y, Fukushima Y, Sugimori H, Kitazono T; FSR Investigators.

    Stroke   2011.10

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    DOI: 10.1161/STROKEAHA.111.617415

  • Association of Alzheimer disease pathology with abnormal lipid metabolism: the Hisayama Study Reviewed International journal

    Matsuzaki T, Sasaki K, Hata J, Hirakawa Y, Fujimi K, Ninomiya T, Suzuki SO, Kanba S, Kiyohara Y, Iwaki T.

    Neurology   2011.9

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    DOI: 10.1212/WNL.0b013e31822e145d

  • Glucose tolerance status and risk of dementia in the community: the Hisayama Study Reviewed International journal

    Ohara T, Doi Y, Ninomiya T, Hirakawa Y, Hata J, Iwaki T, Kanba S, Kiyohara Y.

    Neurology   2011.9

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    DOI: 10.1212/WNL.0b013e31822f0435

  • Effects of blood pressure lowering on major vascular events among patients with isolated diastolic hypertension: the Perindopril Protection Against Recurrent Stroke Study (PROGRESS) trial Reviewed International journal

    Arima H, Anderson C, Omae T, Woodward M, Hata J, Murakami Y, Macmahon S, Neal B, Chalmers J; PROGRESS Collaborative Group.

    Stroke   2011.8

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    DOI: 10.1161/STROKEAHA.110.606764

  • Midlife and late-life blood pressure and dementia in Japanese elderly: the Hisayama Study Reviewed International journal

    Ninomiya T, Ohara T, Hirakawa Y, Yoshida D, Doi Y, Hata J, Kanba S, Iwaki T, Kiyohara Y.

    Hypertension   2011.7

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    DOI: 10.1161/HYPERTENSIONAHA.110.163055

  • Apolipoprotein genotype for prediction of Alzheimer's disease in older Japanese: the Hisayama Study Reviewed International journal

    Ohara T, Ninomiya T, Kubo M, Hirakawa Y, Doi Y, Hata J, Iwaki T, Kanba S, Kiyohara Y.

    J Am Geriatr Soc   2011.6

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    DOI: 10.1111/j.1532-5415.2011.03405.x

  • Effectiveness of the salivary occult blood test as a screening method for periodontal status Reviewed International journal

    Shimazaki Y, Akifusa S, Takeshita T, Shibata Y, Doi Y, Hata J, Ninomiya T, Hirakawa Y, Kiyohara Y, Yamashita Y.

    J Periodontol   2011.4

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    DOI: 10.1902/jop.2010.100304

  • Body mass index and stroke incidence in a Japanese community: the Hisayama Study Reviewed

    Yonemoto K, Doi Y, Hata J, Ninomiya T, Fukuhara M, Ikeda F, Mukai N, Iida M, Kiyohara Y.

    Hypertens Res   2011.2

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    DOI: 10.1038/hr.2010.220

  • Albuminuria as a risk factor for peripheral arterial disease in a general population: the Hisayama Study Reviewed

    Usui T, Ninomiya T, Nagata M, Doi Y, Hata J, Fukuhara M, Kiyohara Y.

    J Atheroscler Thromb   2011.1

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    DOI: 10.5551/jat.7682

  • Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community: the Hisayama Study Reviewed International journal

    Sekita A, Ninomiya T, Tanizaki Y, Doi Y, Hata J, Yonemoto K, Arima H, Sasaki K, Iida M, Iwaki T, Kanba S, Kiyohara Y.

    Acta Psychiatr Scand   2010.10

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    DOI: 10.1111/j.1600-0447.2010.01587.x

  • Circulating resistin is increased with decreasing renal function in a general Japanese population: the Hisayama Study Reviewed International journal

    Kawamura R, Doi Y, Osawa H, Ninomiya T, Hata J, Yonemoto K, Tanizaki Y, Iida M, Makino H, Kiyohara Y.

    Nephrol Dial Transplant   2010.10

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    DOI: 10.1093/ndt/gfq155

  • QT interval prolongation and the risks of stroke and coronary heart disease in a general Japanese population: the Hisayama Study Reviewed

    Maebuchi D, Arima H, Doi Y, Ninomiya T, Yonemoto K, Tanizaki Y, Kubo M, Hata J, Matsumura K, Iida M, Kiyohara Y.

    Hypertens Res   2010.9

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    DOI: 10.1038/hr.2010.88

  • Trends in the prevalence of chronic kidney disease and its risk factors in a general Japanese population: the Hisayama Study Reviewed International journal

    Nagata M, Ninomiya T, Doi Y, Yonemoto K, Kubo M, Hata J, Tsuruya K, Iida M, Kiyohara Y.

    Nephrol Dial Transplant   2010.8

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    DOI: 10.1093/ndt/gfq062

  • Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama Study Reviewed International journal

    Matsuzaki T, Sasaki K, Tanizaki Y, Hata J, Fujimi K, Matsui Y, Sekita A, Suzuki SO, Kanba S, Kiyohara Y, Iwaki T.

    Neurology   2010.8

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    DOI: 10.1212/WNL.0b013e3181eee25f

  • Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population Reviewed International journal

    Matsushita T, Umeno J, Hirakawa Y, Yonemoto K, Ashikawa K, Amitani H, Ninomiya T, Hata J, Doi Y, Kitazono T, Iida M, Nakamura Y, Kiyohara Y, Kubo M.

    J Hum Genet   2010.7

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    DOI: 10.1038/jhg.2010.45

  • Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke Reviewed International journal

    Matsushita T, Ashikawa K, Yonemoto K, Hirakawa Y, Hata J, Amitani H, Doi Y, Ninomiya T, Kitazono T, Ibayashi S, Iida M, Nakamura Y, Kiyohara Y, Kubo M.

    Hum Mol Genet   2010.3

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    DOI: 10.1093/hmg/ddp582

  • Impact of glucose tolerance status on development of ischemic stroke and coronary heart disease in a general Japanese population: the Hisayama Study Reviewed International journal

    Doi Y, Ninomiya T, Hata J, Fukuhara M, Yonemoto K, Iwase M, Iida M, Kiyohara Y.

    Stroke   2010.2

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    DOI: 10.1161/STROKEAHA.109.564708

  • Impact of blood pressure levels on different types of stroke: the Hisayama Study Reviewed International journal

    Arima H, Tanizaki Y, Yonemoto K, Doi Y, Ninomiya T, Hata J, Fukuhara M, Matsumura K, Iida M, Kiyohara Y.

    J Hypertens   2009.12

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    DOI: 10.1097/HJH.0b013e328330e882

  • Development and validation of a cardiovascular risk prediction model for Japanese: the Hisayama Study Reviewed

    Arima H, Yonemoto K, Doi Y, Ninomiya T, Hata J, Tanizaki Y, Fukuhara M, Matsumura K, Iida M, Kiyohara Y.

    Hypertens Res   2009.12

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    DOI: 10.1038/hr.2009.161

  • Impact of metabolic syndrome compared with impaired fasting glucose on the development of type 2 diabetes in a general Japanese population: the Hisayama Study Reviewed International journal

    Mukai N, Doi Y, Ninomiya T, Hata J, Yonemoto K, Iwase M, Iida M, Kiyohara Y.

    Diabetes Care   2009.12

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    DOI: 10.2337/dc09-0896

  • Diabetes and hypertension markedly increased the risk of ischemic stroke associated with high serum resistin concentration in a general Japanese population: the Hisayama Study Reviewed International journal

    Osawa H, Doi Y, Makino H, Ninomiya T, Yonemoto K, Kawamura R, Hata J, Tanizaki Y, Iida M, Kiyohara Y.

    Cardiovasc Diabetol   2009.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1475-2840-8-60

  • Flow volume and cross-sectional area of the extracranial vertebral arteries and its relation to vascular lesions or anatomical variations in the posterior circulation Reviewed International journal

    Wakugawa Y, Sugimori H, Nakane H, Hata J, Irie K, Kitazono T, Iida M.

    Ultrasound Med Biol   2009.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ultrasmedbio.2009.01.006

  • Proposed criteria for metabolic syndrome in Japanese based on prospective evidence: the Hisayama Study Reviewed International journal

    Doi Y, Ninomiya T, Hata J, Yonemoto K, Arima H, Kubo M, Tanizaki Y, Iwase M, Iida M, Kiyohara Y.

    Stroke   2009.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.108.531319

  • Lack of association between variations of PDE4D and ischemic stroke in the Japanese population Reviewed International journal

    Matsushita T, Kubo M, Yonemoto K, Ninomiya T, Ashikawa K, Liang B, Hata J, Doi Y, Kitazono T, Ibayashi S, Iida M, Kiyohara Y, Nakamura Y.

    Stroke   2009.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.108.527408

  • Hyperglycemia increases risk of gastric cancer posed by helicobacter pylori infection: a population-based cohort study Reviewed International journal

    Ikeda F, Doi Y, Yonemoto K, Ninomiya T, Kubo M, Shikata K, Hata J, Tanizaki Y, Matsumoto T, Iida M, Kiyohara Y.

    Gastroenterology   2009.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1053/j.gastro.2008.12.045

  • LDL cholesterol and the development of stroke subtypes and coronary heart disease in a general Japanese population: the Hisayama Study Reviewed International journal

    Imamura T, Doi Y, Arima H, Yonemoto K, Hata J, Kubo M, Tanizaki Y, Ibayashi S, Iida M, Kiyohara Y.

    Stroke   2009.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.108.529537

  • Seroprevalence of herpes simplex virus 1 and 2 in a population-based cohort in Japan Reviewed

    Doi Y, Ninomiya T, Hata J, Yonemoto K, Tanizaki Y, Arima H, Liu Y, Rahman M, Iida M, Kiyohara Y.

    J Epidemiol   2009.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2188/jea.je20080061

  • Fasting plasma glucose cutoff for diagnosis of diabetes in a Japanese population Reviewed International journal

    Doi Y, Kubo M, Yonemoto K, Ninomiya T, Iwase M, Arima H, Hata J, Tanizaki Y, Iida M, Kiyohara Y.

    J Clin Endocrinol Metab   2008.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/jc.2007-2819

  • High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese: the Hisayama Study Reviewed International journal

    Arima H, Kubo M, Yonemoto K, Doi Y, Ninomiya T, Tanizaki Y, Hata J, Matsumura K, Iida M, Kiyohara Y.

    Arterioscler Thromb Vasc Biol   2008.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/ATVBAHA.107.157164

  • Polymorphism in the sorbin and SH3-domain-containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population: the Fukuoka Stroke Registry and the Hisayama study Reviewed International journal

    Hagiwara N, Kitazono T, Kamouchi M, Kuroda J, Ago T, Hata J, Ninomiya T, Ooboshi H, Kumai Y, Yoshimura S, Tamaki K, Fujii K, Nagao T, Okada Y, Toyoda K, Nakane H, Sugimori H, Yamashita Y, Wakugawa Y, Kubo M, Tanizaki Y, Kiyohara Y, Ibayashi S, Iida M; Fukuoka Stroke Registry; Hisayama Study.

    Eur J Neurol   2008.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1468-1331.2008.02105.x

  • Polymorphisms in the lymphotoxin alpha gene and the risk of ischemic stroke in the Japanese population. the Fukuoka Stroke Registry and the Hisayama Study Reviewed International journal

    Hagiwara N, Kitazono T, Kamouchi M, Kuroda J, Ago T, Hata J, Ninomiya T, Ooboshi H, Kumai Y, Yoshimura S, Tamaki K, Fujii K, Nagao T, Okada Y, Toyoda K, Nakane H, Sugimori H, Yamashita Y, Wakugawa Y, Kubo M, Tanizaki Y, Kiyohara Y, Ibayashi S, Iida M.

    Cerebrovasc Dis   2008.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000121342

  • Impact of Kir6.2 E23K polymorphism on the development of type 2 diabetes in a general Japanese population: the Hisayama Study Reviewed International journal

    Doi Y, Kubo M, Ninomiya T, Yonemoto K, Iwase M, Arima H, Hata J, Tanizaki Y, Iida M, Kiyohara Y.

    Diabetes   2007.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/db06-1709

  • A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction Reviewed International journal

    Kubo M, Hata J, Ninomiya T, Matsuda K, Yonemoto K, Nakano T, Matsushita T, Yamazaki K, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Sueishi K, Iida M, Nakamura Y, Kiyohara Y.

    Nat Genet   2007.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ng1945

  • Decreasing incidence of lacunar vs other types of cerebral infarction in a Japanese population Reviewed International journal

    Kubo M, Kiyohara Y, Ninomiya T, Tanizaki Y, Yonemoto K, Doi Y, Hata J, Oishi Y, Shikata K, Iida M.

    Neurology   2006.5

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    DOI: 10.1212/01.wnl.0000216132.95207.b4

  • C-reactive protein and risk of first-ever ischemic and hemorrhagic stroke in a general Japanese population: the Hisayama Study Reviewed International journal

    Wakugawa Y, Kiyohara Y, Tanizaki Y, Kubo M, Ninomiya T, Hata J, Doi Y, Okubo K, Oishi Y, Shikata K, Yonemoto K, Maebuchi D, Ibayashi S, Iida M.

    Stroke   2006.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/01.STR.0000194958.88216.87

  • Chronic kidney disease and cardiovascular disease in a general Japanese population: the Hisayama Study Reviewed International journal

    Ninomiya T, Kiyohara Y, Kubo M, Tanizaki Y, Doi Y, Okubo K, Wakugawa Y, Hata J, Oishi Y, Shikata K, Yonemoto K, Hirakata H, Iida M.

    Kidney Int   2005.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1523-1755.2005.00397.x

  • Hyperhomocysteinemia and the development of chronic kidney disease in a general population: the Hisayama Study Reviewed International journal

    Ninomiya T, Kiyohara Y, Kubo M, Tanizaki Y, Tanaka K, Okubo K, Nakamura H, Hata J, Oishi Y, Kato I, Hirakata H, Iida M.

    Am J Kidney Dis   2004.9

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Books

  • B.循環器病を引き起こす要因は何か B-1 脳卒中の危険因子 循環器病予防エビデンスブックVol.1 日本循環器病予防学会 三浦克之、大久保孝義(編)

    秦 淳、二宮 利治(Role:Joint author)

    2021.6 

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    Language:Japanese   Book type:Scholarly book

  • 第6章 知っておきたい血圧変動関連の臨床研究 20.ADVANCE研究サブ解析 血圧変動エビデンス&プラクティス 楽木宏美(編)

    秦 淳(Role:Joint author)

    先端医学社  2016.5 

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    Responsible for pages:p175   Language:Japanese   Book type:Scholarly book

  • 第1章 脳出血診療 3.脳出血の疫学 脳出血・くも膜下出血診療読本 豊田一則, 髙橋 淳(編)

    秦 淳, 清原 裕(Role:Joint author)

    中外医学社  2016.4 

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    Responsible for pages:p39-47   Language:Japanese   Book type:Scholarly book

  • 心房細動(AF)/心房細動による脳卒中の疫学 ファーマナビゲーター抗凝固療法編 山下武志, 是恒之宏, 矢坂正弘(編)

    古田 芳彦, 秦 淳, 清原 裕(Role:Joint author)

    メディカルレビュー社  2015.4 

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    Responsible for pages:pp92-101   Language:Japanese   Book type:Scholarly book

Presentations

  • 日本人地域住民におけるサルコペニアの疫学 Invited

    秦淳、二宮利治

    第44回日本肥満学会・第41回日本肥満症治療学会学術集会  2023.11 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:仙台市   Country:Japan  

  • 地域疫学研究を基盤とした脳梗塞発症のリスク予測:久山町研究 Invited

    秦淳、二宮利治

    第66回日本脳循環代謝学会学術集会  2023.11 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡市   Country:Japan  

  • 脳卒中予防の最前線:久山町研究の成績より Invited

    秦淳、二宮利治

    第59回日本循環器病予防学会学術集会  2023.6 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:鹿児島   Country:Japan  

  • 地域型コホート研究からみた脳卒中の一次予防:久山町研究 Invited

    秦淳、二宮利治

    第48回日本脳卒中学会学術集会  2023.3 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • Conventional and novel risk factors for cardiovascular disease: the Hisayama Study Invited

    秦淳、二宮利治

    第87回日本循環器学会学術集会  2023.3 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 日本人を対象とした動脈硬化性疾患の新しい発症リスク予測モデル:久山町研究 Invited

    秦淳、本田貴紀、陳三妹、二宮利治

    第70回日本心臓病学会学術集会  2022.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • 脳卒中の危険因子とその予防 Invited

    秦淳、二宮利治

    第54回日本動脈硬化学会総会・学術集会  2022.7 

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    Event date: 2022.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:久留米   Country:Japan  

  • 久山町研究を基盤とした脳梗塞のゲノム疫学研究 Invited

    秦淳,二宮利治

    第57回日本循環器病予防学会学術集会  2021.6 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:ライブ配信   Country:Japan  

    脳梗塞は複数の環境要因と遺伝要因が組み合わさることにより発症すると考えられている。近年、世界各国で脳梗塞のゲノムワイド関連研究(GWAS)が実施され、エビデンスが蓄積されつつある。本講演では,福岡県久山町で継続中の疫学調査(久山町研究)が参加した脳梗塞のゲノム疫学研究の成果について概説する。
     まず、九州大学病院および近郊の医療機関を受診した脳梗塞患者1,112名(福岡脳卒中データベース研究 [FSR])を患者群,2002年に久山町の循環器健診を受診した心血管病の既往のない1,112名(久山町研究)を対照群として、脳梗塞のGWASを実施した.遺伝子領域を中心に抽出した52,608箇所の一塩基多型(SNP)を網羅的に解析したところ、PRKCH,AGTRL1,ARHGEF10を新規の脳梗塞関連遺伝子として見出した.さらに,1988年の久山町健診受診者1,642名を14年間追跡した成績を用いて,これらの遺伝子多型が新規脳梗塞の発症リスクと有意に関連することを明らかにした.
     続いて、岩手医科大学、理化学研究所および国内の主な疫学研究との共同研究において脳梗塞のポリジェニック・リスクスコア(PRS)を開発した。この研究では、バイオバンク・ジャパン、東北メディカルメガバンク、JPHC研究、J-MICC研究のGWASデータ(患者群13,214名、対照群26,470名)の統合研究により、357,367箇所のSNPsを用いたPRSを作成し、先述のFSRと久山町研究によるGWASサンプルを用いて、PRSの外的妥当性を検証した。さらに、2002年の久山町健診受診者3,038名を10年間追跡した成績を用いて、PRSが新規脳梗塞の発症リスクと関連することを確認した。
    今後、環境要因と遺伝要因の脳梗塞発症への相互的な影響が明らかになることにより、脳梗塞の個別的な予防に寄与することが期待される。

  • 脳卒中発症の危険因子としてのバイオマーカー:久山町研究 Invited

    秦淳,二宮利治

    第46回日本脳卒中学会学術集会  2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

    久山町研究は、福岡県久山町の地域一般住民を対象に1961年に創設された生活習慣病の疫学研究である。本研究では、高血圧、糖尿病、脂質異常症、喫煙習慣などの古典的な危険因子に関する評価に加えて、血清、尿などの生体試料を用いて測定した新規のバイオマーカーと循環器病発症の関係を検討している。
     動脈硬化の進展には血管壁の慢性炎症が関与していることはよく知られており、血清中の高感度C反応性蛋白(HS-CRP)は代表的な慢性炎症のバイオマーカーである。久山町研究では、1988年に久山町の循環器病健診を受診した40歳以上の住民2,589名を14年間追跡した成績を用いて血清HS-CRP値と脳卒中発症の関係を検討した。その結果、男性において血清HS-CRP値と脳梗塞発症リスクとの間に有意な正の関連があり、この関連は古典的な危険因子と独立していた。また、血清中のlipopolysaccharide結合蛋白(LBP)は肝臓で産生される急性期反応蛋白であり、ヒト腸内細菌叢などに生息しているグラム陰性桿菌の細胞壁構成因子であるlipopolysaccharideと複合体を形成することにより、マクロファージ活性化と慢性炎症誘導に関与することが知られている。そこで、2002年に久山町の循環器病健診を受診した40歳以上の住民2,568名を10年間追跡した成績を用いて血清LBP値と脳卒中発症の関係を検討したところ、血清LBP値の上昇に伴い脳卒中の発症リスク(多変量調整後)は有意に上昇した。
     本講演では、久山町研究のコホート研究の成績を用いて、炎症や心障害などに関するさまざまなバイオマーカーと脳卒中などの循環器疾患の発症との関連について概説する。

  • 日本人地域住民における動脈硬化性疾患とその危険因子の推移:久山町研究 Invited

    秦淳,二宮利治

    第52回日本動脈硬化学会総会・学術集会  2020.7 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:ライブ配信   Country:Japan  

    福岡県久山町では、1961年より循環器健診を受診した40歳以上の住民を対象に時代の異なる複数の前向きコホートを設定し,動脈硬化性疾患の危険因子に関する疫学調査(久山町研究)継続している.本研究では、脳卒中・虚血性心疾患の発症および死亡に関する追跡調査を行っているが、各コホートの受診率,追跡率は高く,死亡例の約75%において剖検を行い疾病や死因について詳細に評価している.したがって,本研究の成績は日本人地域住民における動脈硬化性疾患とその危険因子の実態を比較的正確に反映していると考えられる.
    本研究の成績によると,高血圧管理の向上や喫煙率の低下にともない,脳卒中および脳梗塞の年齢調整罹患率は1960年代から1970年代にかけて大きく低下した.しかし,1980年代以降はこれらの罹患率の低下の程度が鈍化した.一方,虚血性心疾患の罹患率には明らかな時代的変化はなかった.代謝性の危険因子である糖代謝異常(糖尿病・前糖尿病),高コレステロール血症,肥満の有病率が時代とともに増加したことにより,高血圧管理の向上や喫煙率の低下による動脈硬化性疾患発症の予防効果を相殺した可能性がある.さらに脳梗塞発症例をタイプ別に検討すると,高血圧を主因とするラクナ梗塞の占める割合は時代とともに低下し,代謝性危険因子を主因とするアテローム血栓性脳梗塞や,人口の高齢化を反映して心房細動などの心疾患を主因とする心原性脳塞栓症の占める割合が相対的に増加した.
    本講演では,約60年にわたる久山町研究の成績を用いて,動脈硬化性疾患とその危険因子の時代的推移に関する最近の知見を紹介する.

  • 高血圧と心血管病・認知症の疫学:久山町研究 Invited

    秦淳

    第35回日本脳神経血管内治療学会学術総会  2019.11 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡   Country:Japan  

  • 糖尿病,脳梗塞,認知症のゲノム疫学研究 Invited

    秦淳,二宮利治

    第51回日本動脈硬化学会総会・学術集会  2019.7 

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    Event date: 2019.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • 福岡県久山町における認知症の疫学研究 Invited

    秦淳,小原知之,二宮利治

    第8回臨床高血圧フォーラム,第55回日本循環器病予防学会学術集会  2019.5 

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    Event date: 2019.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:久留米   Country:Japan  

  • 脳卒中の疫学 Invited

    秦淳

    第44回日本脳卒中学会学術集会  2019.3 

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    Event date: 2019.3 - 2019.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • 心血管病の新しい危険因子としてのバイオマーカー: 久山町研究 Invited

    秦淳,二宮利治

    第64回日本心臓病学会学術集会  2016.9 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 性別・年齢階級別にみた脳卒中とその危険因子の疫学 Invited

    秦淳

    第42回日本脳卒中学会学術総会  2017.3 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • 福岡県久山町における認知症の疫学研究コホート研究から得られた認知症に関する最近の知見

    秦淳,小原知之,二宮利治

    第55回日本循環器病予防学会学術集会  2019.5 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:久留米   Country:Japan  

  • 食環境と健康長寿のフロンティア. 生活習慣病のオーダーメイド予防:久山町研究. Invited

    秦淳,久保充明,清原裕

    日本栄養・食糧学会九州・沖縄支部. 佐賀大学産学官連携推進機構および佐賀大学医食同源プロジェクト合同公開講座  2007.4 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:佐賀   Country:Japan  

  • 久山町研究を基盤とした脳梗塞のゲノムワイド関連遺伝子研究 Invited

    秦淳,清原裕

    第63回日本臨床眼科学会・第10回眼科DNAチップ研究会  2009.10 

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    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡   Country:Japan  

  • 久山町研究を基盤とした脳梗塞のゲノムワイド関連研究 Invited

    秦淳,久保充明,清原裕

    第80回日本衛生学会学術総会  2010.5 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:仙台   Country:Japan  

  • 一般住民における心房細動の特徴と予後 Invited

    秦淳,後藤聖司,福原正代,清原裕

    第37回日本脳卒中学会総会  2012.4 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • Stroke epidemiology in Japan: the Hisayama Study Invited International conference

    Hata J,Kiyohara Y

    2nd Asia Pacific Stroke Conference  2012.9 

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    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • Diabetes mellitus as a risk factor for cancer: the Hisayama Study Invited

    Hata J,Kiyohara Y

    第72回日本癌学会学術総会  2013.10 

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    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • 脳卒中のバイオマーカー:久山町研究 Invited

    秦淳,清原裕

    第39回日本脳卒中学会総会  2014.3 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  • 心血管病と認知症の疫学:久山町研究 Invited

    秦淳,清原裕

    第56回日本老年医学会学術集会  2014.6 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 日本人における心血管病危険因子の時代的変化と特徴:久山町研究 Invited

    秦淳,清原裕

    第17回日本栓子検出と治療学会  2014.10 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 糖代謝異常・脂質異常症と脳卒中の疫学:久山町研究 Invited

    秦淳,清原裕

    第40回日本脳卒中学会総会  2015.3 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:広島   Country:Japan  

  • 動脈硬化性疾患の新しい危険因子:久山町研究から Invited

    秦淳,清原裕

    第47回日本動脈硬化学会総会・学術集会  2015.7 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:仙台   Country:Japan  

  • 高血圧と心臓合併症の疫学:久山町研究を中心に Invited

    秦淳,清原裕,二宮利治

    第38回日本高血圧学会総会  2015.10 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:松山   Country:Japan  

  • Risk factors for carotid atherosclerosis: the Hisayama Study. Invited

    Hata J,Ninomiya T.

    第49回日本動脈硬化学会総会・学術集会  2017.7 

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    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:広島   Country:Japan  

  • 網羅的ゲノム解析による脳梗塞関連遺伝子の探索 Invited

    秦淳

    第43回日本脳卒中学会学術総会  2018.3 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 血清angiopoietin-like protein 2 (ANGPTL2)濃度と死因別死亡の関連:久山町研究

    秦淳、坂田智子、古田芳彦、大石絵美、本田貴紀、柴田舞欧、北園孝成、尾池雄一、二宮利治

    第60回日本循環器病予防学会学術集会  2024.5 

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    Event date: 2024.5

    Language:Japanese  

    Venue:東京都   Country:Japan  

  • 日本人地域住民における心房細動発症のリスク予測モデルの開発:久山町研究

    秦淳,坂田智子,永田拓也,平川洋一郎,大石絵美,本田貴紀,吉田大悟,北園孝成,二宮利治

    第55回日本循環器病予防学会学術集会  2019.5 

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    Event date: 2019.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:久留米   Country:Japan  

  • βアラニン血中濃度と認知症発症の関連:久山町研究

    秦淳,小原知之,片倉喜範,清水邦義,山下俊太郎,吉田大悟,本田貴紀,平川洋一郎,柴田舞欧,坂田智子,北園孝成,久原哲,二宮利治

    第25回日本未病システム学会学術総会  2018.10 

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    Event date: 2018.10 - 2019.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

    【背景】わが国では認知症とくにアルツハイマー型認知症(AD)の有病率が時代とともに増加し,その予防対策は医療的・社会的に重要な課題となっている.近年の疫学研究により,栄養・食事性因子と認知症発症の関連が検討されるようになり,その発症予防に有用な機能性食品の開発も進められている.そのなかで,鶏肉に多く含有するイミダゾールジペプチドとして知られるカルノシン・アンセリンの摂取が抗酸化作用・抗糖化作用・抗炎症作用を介して認知機能障害に予防的に作用することが,健常者を対象とした介入研究および動物実験によって明らかとされつつある.しかし,地域住民を対象とした疫学研究によってこれらのジペプチドと認知症の発症リスクとの関連について検討した報告は存在しない.
    【目的】福岡県久山町の地域高齢者を対象とした追跡調査の成績を用いて,カルノシン・アンセリンの分解産物であるβアラニンの血中濃度と認知症の発症リスクとの関連について検討した.
    【方法】2007年に久山町の循環器健診を受診した認知症のない60~79歳の男女1,475名を対象とした.健診時に採取した血清を用いてβアラニンの血中濃度を液体クロマトグラフ質量分析法により測定し,その4分位を用いてQ1群0.29-0.76 μmol/L,Q2群0.77-0.96 μmol/L,Q3群0.97-1.22 μmol/L,Q4群1.23-8.34 μmol/Lに分類した.この集団を2012年まで追跡し,βアラニン血中濃度と認知症およびその主要病型(AD,血管性認知症[VaD])の発症リスクとの関連をKaplan-Meier法およびCox比例ハザードモデルを用いて検討した.
    【結果】5.3年間(中央値)の追跡期間中に117名が認知症を発症した(AD 77名,VaD 31名).5年間の全認知症の累積罹患率は,βアラニン血中濃度が高くなるとともに有意に低下した(Q1群9.9%,Q2群8.6%,Q3群4.9%,Q4群4.7%).同様の関連はADの累積罹患率についても認められた(Q1群6.8%,Q2群5.5%,Q3群3.5%,Q4群2.5%).一方,VaDの累積罹患率との間には明らかな関連を認めなかった(Q1群1.8%,Q2群2.4%,Q3群1.5%,Q4群2.0%).さらに,性,年齢,教育歴,収縮期血圧,降圧薬使用,糖尿病,血清総コレステロール値,BMI,脳卒中既往,喫煙,飲酒,運動習慣,総エネルギー摂取量で調整した多変量解析においても,βアラニン血中濃度の上昇に伴い,全認知症およびAD発症のハザード比[95%信頼区間]は有意に低下した(全認知症:Q1群1.00 [基準], Q2群0.73 [0.45-1.18],Q3群0.50 [0.28-0.89],Q4群0.50 [0.27-0.92],傾向性p=0.01.AD:Q1群1.00 [基準], Q2群0.78 [0.44-1.38],Q3群0.53 [0.26-1.06] ,Q4群0.53 [0.25-1.10],傾向性p=0.04).
    【結論】日本人の地域高齢者において,βアラニン血中濃度の高値は認知症とくにADの有意な独立した保護因子であった.鶏肉などカルノシン・アンセリンあるいはβアラニンを含有する食事をより多く摂取することにより,認知症の予防につながることが示唆される.

  • 地域住民における白衣高血圧,仮面高血圧とアルブミン尿症の関連:久山町研究 Invited

    秦淳,福原正代,坂田智子,有馬久富,平川洋一郎,米本孝二,向井直子,北園孝成,清原裕,二宮利治

    第41回日本高血圧学会総会  2018.9 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:旭川   Country:Japan  

    【背景と目的】近年,診察室血圧に加えて家庭血圧の測定が推奨されるようになり,白衣高血圧(WCHT)や仮面高血圧(MHT)の臨床的意義が注目されている。しかし,これらの血圧異常が慢性腎臓病(CKD)およびその構成因子(アルブミン尿症,腎機能低下)におよぼす影響について検討した疫学調査の報告は少ない.そこで,福岡県久山町の地域住民における疫学調査の成績を用いてこれらの関連について検討した.
    【対象と方法】2007年に久山町循環器健診を受診し,家庭血圧測定を行った40歳以上の住民2974名を対象とした.家庭血圧は早朝起床後に座位で連続3回28日間測定,診察室血圧は健診会場にて座位で連続3回測定し,それぞれの平均値を用いて,対象者を正常血圧(NT)群(家庭血圧<135/85 mmHgかつ診察室血圧<140/90 mmHg: n=1388),WCHT群(家庭血圧<135/85 mmHgかつ診察室血圧≧140/90 mmHg: n=209),MHT群(家庭血圧≧135/85 mmHgかつ診察室血圧<140/90 mmHg: n=642),持続性高血圧(SHT)群(家庭血圧≧135/85 mmHgかつ診察室血圧≧140/90 mmHg: n=735)の4群に分類した.CKDはアルブミン尿症(尿中アルブミン/クレアチニン比≧30 mg/g)または腎機能低下(推算糸球体濾過量<60 ml/分/1.73 m2)のいずれかと定義した.血圧分類とCKDおよびその構成因子との関連は,ロジスティック回帰を用いて検討した.
    【結果】NT群を基準としたCKDの性年齢調整後のオッズ比(95%信頼区間)はWCHT群2.05(1.49-2.81),MHT群1.53(1.23-1.90),SHT群3.34(2.71-4.11)であり,いずれのタイプの高血圧においてもCKDを有する可能性が有意に高かった.さらに,主な心血管危険因子の影響を多変量調整したところ,WCHT群とSHT群において有意な関連を認めた(オッズ比[95%信頼区間]:WCHT群1.64[1.18-2.28],MHT群1.20[0.95-1.52],SHT群2.62[2.10-3.27]).CKDの構成因子別に検討したところ,WCHT,MHT,SHTはいずれもアルブミン尿症と有意に関連した(多変量調整オッズ比[95%信頼区間]:WCHT群1.77[1.22-2.57],MHT群1.74[1.34-2.26],SHT群3.93[3.08-5.01]).しかし,これらの血圧分類と腎機能低下との間には明らかな関連はなかった.
    【結論】地域住民を対象とした横断研究により,SHT者のみならずWCHT者やMHT者においてもNT者と比べてCKD、特にアルブミン尿症を有するリスクが高くなることが示唆された.今後は前向き追跡研究による検証が必要である.

  • 慢性期循環器疾患患者における死亡リスク予測モデルの開発:バイオバンク・ジャパン

    秦淳,永井亜貴子,平田真,鎌谷洋一郎,玉腰暁子,山縣然太朗,武藤香織,松田浩一,久保充明,清原裕,二宮利治

    第27回日本疫学会学術総会  2017.1 

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    Event date: 2017.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:甲府   Country:Japan  

  • 経口腔エコーが有用であった内頚動脈狭窄症の一例

    秦 淳,岸川和裕,永富葉子,荒川修治,鴨打正浩,岡田 靖,井上 亨,安森弘太郎

    第148回日本神経学会九州地方会  1999.12 

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    Venue:大分   Country:Japan  

  • 肝細胞癌に対する皮下埋め込み型動注システム留置中に発症した脳梗塞4症例の検討

    秦 淳,竹迫仁則,中村 宏,古賀政利,六倉和生,井上 剛,朔 義亮

    第151回日本神経学会九州地方会  2000.9 

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    Venue:佐賀   Country:Japan  

  • 肝悪性腫瘍に対する皮下植え込み型動注システムに発症した脳梗塞症例の検討

    秦 淳,竹迫仁則,中村 宏,井上 剛,古賀政利,六倉和生,朔 義亮,井林雪郎

    第26回日本脳卒中学会総会  2001.3 

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    Venue:大阪   Country:Japan  

  • 地域住民における脳卒中の病型別再発率の検討:久山町研究

    秦淳,谷崎弓裕,清原裕,加藤功,久保充明,田中圭一,大久保賢,中村秀敏,尾石義謙,井林雪郎,飯田三雄

    第28回日本脳卒中学会総会  2003.3 

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    Venue:東京   Country:Japan  

  • 純粋型レビー小体型痴呆の1剖検例

    秦淳,谷崎弓裕,脇坂義信,清原裕,加藤功,久保充明,大久保賢,田中圭一,中村秀敏,尾石義謙,飯田三雄

    第13回日本老年医学会九州地方会  2003.3 

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    Venue:熊本   Country:Japan  

  • 一般住民におけるメタボリックシンドロームがタイプ別脳梗塞の発症に及ぼす影響:久山町研究

    秦淳,谷崎弓裕,土井康文,二宮利治,有馬久富,今村剛,米本孝二,清原裕,井林雪郎,飯田三雄

    第18回日本疫学会学術総会  2008.1 

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    Venue:東京   Country:Japan  

  • メタボリックシンドロームは全ての脳梗塞タイプの有意な危険因子である:久山町研究

    秦淳,谷崎弓裕,土井康文,二宮利治,有馬久富,今村剛,米本孝二,井林雪郎,飯田三雄,清原裕

    第33回日本脳卒中学会総会  2008.3 

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    Venue:京都   Country:Japan  

  • AGTRL1遺伝子の一塩基多型(SNP)が脳梗塞の発症に及ぼす影響

    秦淳,久保充明,二宮利治,米本孝二,松下知永,北園孝成,井林雪郎,飯田三雄,中村祐輔,清原裕

    第33回日本脳卒中学会総会  2008.3 

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    Venue:京都   Country:Japan  

  • 新規脳梗塞関連遺伝子AGTRL1の同定と機能解析 Invited

    秦淳,久保充明,北園孝成,飯田三雄,中村祐輔,清原裕

    第9回日本分子脳神経外科学会  2008.8 

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    Venue:京都   Country:Japan  

  • 一般住民における喫煙が脳卒中と虚血性心疾患の発症に及ぼす影響:久山町研究

    秦淳,土井康文,谷崎弓裕,今村剛,福原正代,米本孝二,北園孝成,飯田三雄,清原裕

    第34回日本脳卒中学会総会  2009.3 

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    Venue:松江   Country:Japan  

  • 地域住民における喫煙と虚血性心疾患・脳卒中発症との関連:久山町研究

    秦淳,土井康文,谷崎弓裕,今村剛,福原正代,米本孝二,北園孝成,飯田三雄,清原裕

    第45回日本循環器病予防学会・日本循環器管理研究協議会総会  2009.6 

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    Venue:横浜   Country:Japan  

  • 急性期脳出血に対する積極的降圧療法がmidline shiftと水頭症の進行に及ぼす影響:INTERACT試験

    秦淳,Fullard K,Delcourt C,HeeleyE,有馬久富,Anderson C

    第36回日本脳卒中学会総会  2011.3 

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    Venue:東京   Country:Japan  

  • 2型糖尿病患者における腎機能増悪予測モデル:ADVANCE試験

    秦淳,Jardin M,有馬久富,二宮利治,Zongas S,Perkovic V,Anderson C,Woodward M,Cass A,Patel A,Chalmers J

    第34回日本高血圧学会総会  2011.10 

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    Venue:宇都宮   Country:Japan  

  • 一般住民における脳卒中、虚血性心疾患罹患率とその危険因子の50年にわたる時代的推移:久山町研究

    秦淳,二宮利治,平川洋一郎,永田雅治,向井直子,後藤聖司,福原正代,鴨打正浩,北園孝成,清原裕

    第38回日本脳卒中学会総会  2013.3 

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    Venue:東京   Country:Japan  

  • Angiopoietin-like protein 2 (ANGPTL2) and the risk of cardiovascular disease in a general Japanese population: the Hisayama Study

    Hata J,Ninomiya T,Fukuhara M,Nagata M,Kitazono T,Oike Y,Kiyohara Y

    第79回日本循環器学会学術集会  2015.4 

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    Venue:大阪   Country:Japan  

  • 高齢者の肥満型フレイルにおける脳容積の検討 JPSC-AD研究

    石塚 直樹, 赤坂 博, 佐藤 光信, 佐藤 裕里子, 細川 一貴, 本田 貴紀, 柴田 舞欧, 小原 知之, 秦 淳, 舘脇 康子, 瀧 靖之, 二宮 利治, 前田 哲也

    Dementia Japan  2023.10  (一社)日本認知症学会

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  • 認知症評価における頭部MRI画像を用いた白質病変容積計測システムの有用性の検討

    二宮 利治, 柴田 舞欧, 秦 淳

    日本公衆衛生学会総会抄録集  2024.10  日本公衆衛生学会

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  • 血清脂質値の性・年齢階級別の検証 sdLDLコレステロールを中心に 久山町研究

    坂田 智子, 大石 絵美, 本田 貴紀, 柴田 舞欧, 秦 淳, 二宮 利治

    日本公衆衛生学会総会抄録集  2024.10  日本公衆衛生学会

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  • 血清angiopoietin-like protein 2(ANGPTL2)濃度と死因別死亡の関連 久山町研究

    秦 淳, 坂田 智子, 古田 芳彦, 大石 絵美, 本田 貴紀, 柴田 舞欧, 北園 孝成, 尾池 雄一, 二宮 利治

    日本循環器病予防学会誌  2024.4  (一社)日本循環器病予防学会

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  • 脳心腎臓血管病の予防 脳卒中の危険因子とその予防

    秦 淳, 二宮 利治

    日本動脈硬化学会総会プログラム・抄録集  2022.7  (一社)日本動脈硬化学会

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  • 脳卒中予防の最前線 久山町研究の成績より

    秦 淳, 二宮 利治

    日本循環器病予防学会誌  2023.5  (一社)日本循環器病予防学会

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  • 肥満と医療費との関連 福岡市地域包括ケア情報プラットフォームからの報告

    大石 絵美, 本田 貴紀, 古橋 寛子, 秦 淳, 二宮 利治

    日本公衆衛生学会総会抄録集  2024.10  日本公衆衛生学会

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  • 筋肉・サルコペニアと肥満 日本人地域住民におけるサルコペニアの疫学 久山町研究

    秦 淳, 二宮 利治

    肥満研究  2023.11  (一社)日本肥満学会

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  • 白衣高血圧は心血管病発症の危険因子となるか? 久山町研究

    坂田 智子, 大石 絵美, 秦 淳, 北園 孝成, 二宮 利治

    日本高血圧学会総会プログラム・抄録集  2023.9  (NPO)日本高血圧学会

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  • 日本人地域住民における血清NT-proBNPの変粧と慢性腎臓病発症との関連 久山町研究

    大石 絵美, 坂田 智子, 秦 淳, 北園 孝成, 二宮 利治

    日本高血圧学会総会プログラム・抄録集  2023.9  (NPO)日本高血圧学会

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  • 日本人地域住民における血圧管理レベル別にみた心血管病発症率の時代的推移 久山町研究

    大石 絵美, 坂田 智子, 秦 淳, 平川 洋一郎, 北園 孝成, 二宮 利治

    日本高血圧学会総会プログラム・抄録集  2022.10  (NPO)日本高血圧学会

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  • 日本人地域住民における座位行動と糖代謝マーカーの経時変化および糖尿病発症の関連 久山町研究

    津田 晋, 本田 貴紀, 東岡 真由, 秦 淳, 中野 敏昭, 北園 孝成, 二宮 利治

    Journal of Epidemiology  2024.1  (一社)日本疫学会

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  • 日本人地域住民におけるMetabolically healthy obesityと心血管病発症の関連 久山町研究

    東岡 真由, 秦 淳, 平川 洋一郎, 坂田 智子, 本田 貴紀, 大澤 春彦, 二宮 利治

    日本循環器病予防学会誌  2022.5  (一社)日本循環器病予防学会

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  • 日本人一般集団における家庭血圧の日内変動と心房細動のリスク 久山町研究(Day-to-day Home Blood Pressure Variability and Risk of Atrial Fibrillation in a General Japanese Population: The Hisayama Study)

    前園 明寛, 坂田 智子, 秦 淳, 大石 絵美, 井手 友美, 北園 孝成, 筒井 裕之, 二宮 利治

    日本循環器学会学術集会抄録集  2023.3  (一社)日本循環器学会

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  • 従来の心血管疾患の危険因子と新たな危険因子 久山町研究(Conventional and Novel Risk Factors for Cardiovascular Disease: The Hisayama Study)

    秦 淳, Ninomiya Toshiharu

    日本循環器学会学術集会抄録集  2023.3  (一社)日本循環器学会

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  • 失感情症と慢性疼痛発症の関連及び抑うつ症状の影響 久山町研究

    柴田 舞欧, 二宮 利治, 平林 直樹, 森崎 悠紀子, 安野 広三, 吉田 大悟, 秦 淳, 須藤 信行, 細井 昌子

    日本慢性疼痛学会プログラム・抄録集  2025.2  日本慢性疼痛学会

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  • 地域高齢者における血清高感度CRPと認知症との関連 JPSC-AD研究

    立花 亜由美, 伊賀 淳一, 尾崎 智樹, 吉田 卓, 吉野 祐太, 清水 秀明, 森 崇明, 古田 芳彦, 柴田 舞欧, 小原 知之, 秦 淳, 瀧 靖之, 三上 達也, 前田 哲也, 小野 賢二郎, 三村 將, 中島 健二, 竹林 実, 二宮 利治, 上野 修一

    Dementia Japan  2024.10  (一社)日本認知症学会

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  • 地域高齢住民における歯数とサルコペニア発症との関連 久山町研究

    友岡 祥子, 坂田 智子, 大石 絵美, 本田 貴紀, 秦 淳, 古田 美智子, 山下 喜久, 和田 尚久, 北園 孝成, 二宮 利治

    日本老年医学会雑誌  2023.10  (一社)日本老年医学会

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  • 地域住民における高血圧の有病率・管理状況および心血管病発症リスクの時代的推移 久山町研究

    秦 淳, 大石 絵美, 二宮 利治

    日本高血圧学会総会プログラム・抄録集  2023.9  (NPO)日本高血圧学会

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  • 地域住民における社会的・情緒的孤独感は慢性疼痛と関連する 久山町研究

    柴田 舞欧, 細井 昌子, 秦 淳, 二宮 利治

    日本公衆衛生学会総会抄録集  2024.10  日本公衆衛生学会

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  • 地域住民における社会的・情緒的孤独感と慢性疼痛の関連 久山町研究

    柴田 舞欧, 平林 直樹, 細井 昌子, 安野 広三, 秦 淳, 須藤 信行, 二宮 利治

    日本未病学会学術総会抄録集  2023.12  (一社)日本未病学会

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  • 地域住民における皮膚カロテノイドレベルとメタボリックシンドロームの関連 久山町研究

    木村 安美, 秦 淳, 柴田 舞欧, 本田 貴紀, 坂田 智子, 古田 芳彦, 大石 絵美, 北園 孝成, 二宮 利治

    日本栄養・食糧学会大会講演要旨集  2023.3  (公社)日本栄養・食糧学会

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  • 地域住民における乳頭周囲脈絡膜厚と緑内障の関連:久山町研究

    藤原 康太, 上田 瑛美, 秦 淳, 橋本 左和子, 中村 駿, 村上 祐介, 久保田 敏昭, 吉冨 健志, 二宮 利治, 園田 康平

    日本緑内障学会抄録集  2024.9  日本緑内障学会

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  • 地域住民において尿中神経伝達物質減少は抑うつ症状発症に関連する 久山町研究

    柴田 舞欧, 平林 直樹, 中村 侑里, 細井 昌子, 秦 淳, 須藤 信行, 二宮 利治

    日本未病学会学術総会抄録集  2024.10  (一社)日本未病学会

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  • 全国の一般地域住民における最近の循環器疾患発症率 NIPPON DATA2010

    門田 文, 大久保 孝義, 原田 亜紀子, 高嶋 直敬, 有馬 久富, 二宮 利治, 秦 淳, 寳澤 篤, 中村 幸志, 東山 綾, 大澤 正樹, 久松 隆史, 鳥居 さゆ希, 岡見 雪子, 近藤 慶子, 宮本 恵宏, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之

    Journal of Epidemiology  2024.1  (一社)日本疫学会

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  • 「データベース研究の新展開」 地域疫学研究を基盤とした脳梗塞発症のリスク予測 久山町研究

    秦 淳, 二宮 利治

    脳循環代謝  2023.11  (一社)日本脳循環代謝学会

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  • COPD 疫学 日本人地域住民におけるpreserved ratio impaired spirometryとその予後の検討 久山町研究(アンコール演題)

    鷲尾 康圭, 坂田 智子, 福山 聡, 本田 貴紀, 神尾 敬子, 柴田 舞欧, 秦 淳, 井上 博雅, 北園 孝成, 松元 幸一郎, 二宮 利治

    日本呼吸器学会誌  2023.3  (一社)日本呼吸器学会

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  • ARTAG形成の分布とリスク因子 久山町研究(Distributions and risk factors in ARTAG formation: The Hisayama study)

    八木田 薫, 小原 知之, 濱崎 英臣, 小山 祥子, 野口 英子, 秦 淳, 二宮 利治, 本田 裕之

    Dementia Japan  2022.10  (一社)日本認知症学会

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  • Epidemiology of stroke in a general Japanese population: the Hisayama Study

    Hata J, Ninomiya T

    J Atheroscler Thromb, 2023; 30: 710-719   2023.6

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    DOI: http://doi.org/10.5551/jat.RV22004

  • 動脈硬化性疾患(脳梗塞を含む)の疫学

    秦淳

    medicina   2024.7

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  • 【"とりあえずスタチン"から脱却!-動脈硬化性疾患一次予防・最新の考え方】疫学 動脈硬化性疾患(脳梗塞を含む)の疫学

    秦 淳

    Medicina   61 ( 8 )   1202 - 1206   2024.7   ISSN:0025-7699

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    <文献概要>Point ◎わが国の疫学研究によると,高血圧管理の向上に伴い脳梗塞の罹患率は時代とともに低下している.◎久山町研究によると,脳梗塞に占めるラクナ梗塞の割合は時代とともに低下し,アテローム血栓性脳梗塞と脳塞栓症の占める割合が相対的に増加している.◎急性心筋梗塞の罹患率の時代的推移を検討したわが国の疫学研究の成績は一致しておらず,地域差の存在が示唆される.◎高コレステロール血症は冠動脈疾患とアテローム血栓性脳梗塞に共通の危険因子である.◎今後の動脈硬化性疾患の発症予防においては,糖尿病,高コレステロール血症,肥満など代謝性危険因子の管理が重要である.

  • 冠動脈疾患の一次予防に関する診療ガイドライン2023年改訂版(JCS2023 Guideline on the Primary Prevention of Coronary Artery Disease)

    Fujiyoshi Akira, Kohsaka Shun, Hata Jun, Hara Mitsuhiko, Kai Hisashi, Masuda Daisaku, Miyamatsu Naomi, Nishio Yoshihiko, Ogura Masatsune, Sata Masataka, Sekiguchi Kenji, Takeya Yasushi, Tamura Kouichi, Wakatsuki Akihiko, Yoshida Hiroshi, Fujioka Yoshio, Fukazawa Ryuji, Hamada Osamu, Higashiyama Aya, Kabayama Mai, Kanaoka Koshiro, Kawaguchi Kenjiro, Kosaka Shintaro, Kunimura Ayako, Miyazaki Ayumi, Nii Masaki, Sawano Mitsuaki, Terauchi Masakazu, Yagi Shusuke, Akasaka Takashi, Minamino Tohru, Miura Katsuyuki, Node Koichi, the Japanese Circulation Society Joint Working Group, Japanese Circulation Society, Japan Society of Nutrition and Food Science, Japanese Society of Pediatric Cardiology and Cardiac Surgery, Japan Society for Menopause and Women's Health, Japanese Society of Nephrology, Japanese College of Cardiology, Japanese Association of Cardiac Rehabilitation, Japanese Society of Hypertension, Japan Diabetes Society, Japan Atherosclerosis Society, Japan Geriatrics Society

    Circulation Journal   88 ( 5 )   763 - 842   2024.4   ISSN:1346-9843

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  • 中高年者における座位時間と糖尿病および糖代謝指標の縦断的関連 久山町研究(Longitudinal association of sedentary time with diabetes mellitus and markers of glucose metabolism in middle-aged and older adults: The Hisayama Study)

    Tsuda Susumu, Honda Takanori, Higashioka Mayu, Hata Jun, Nakano Toshiaki, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Diabetes Investigation   15 ( 2 )   245 - 246   2024.2   ISSN:2040-1116

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  • 脳卒中疫学:最近の傾向

    秦淳、二宮利治

    日本臨牀   2023.9

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  • 【脳卒中診療update-診断・治療の最新動向-】脳卒中疫学 最近の傾向

    秦 淳, 二宮 利治

    日本臨床   81 ( 9 )   1357 - 1362   2023.9   ISSN:0047-1852

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  • 日本人一般集団における脳卒中の疫学 久山町研究(Epidemiology of Stroke in a General Japanese Population: The Hisayama Study)

    Hata Jun, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   30 ( 7 )   710 - 719   2023.7   ISSN:1340-3478

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  • 地域住民におけるサルコペニア肥満と心血管病発症の関連 久山町研究

    瀬戸山 優, 多治見 昂洋, 本田 貴紀, 秦 淳, 北園 孝成, 中島 康晴, 二宮 利治

    日本整形外科学会雑誌   97 ( 2 )   S395 - S395   2023.3   ISSN:0021-5325

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  • 地域高齢住民におけるサルコペニアと脳萎縮との関連 久山町研究

    多治見 昂洋, 平林 直樹, 古田 芳彦, 本田 貴紀, 秦 淳, 小原 知之, 柴田 舞欧, 北園 孝成, 中島 康晴, 二宮 利治

    日本整形外科学会雑誌   97 ( 2 )   S392 - S392   2023.3   ISSN:0021-5325

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  • Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries (Nature, (2022), 611, 7934, (115-123), 10.1038/s41586-022-05165-3)

    Mishra A., Malik R., Hachiya T., Jürgenson T., Namba S., Posner D.C., Kamanu F.K., Koido M., Le Grand Q., Shi M., He Y., Georgakis M.K., Caro I., Krebs K., Liaw Y.C., Vaura F.C., Lin K., Winsvold B.S., Srinivasasainagendra V., Parodi L., Bae H.J., Chauhan G., Chong M.R., Tomppo L., Akinyemi R., Roshchupkin G.V., Habib N., Jee Y.H., Thomassen J.Q., Abedi V., Cárcel-Márquez J., Nygaard M., Leonard H.L., Yang C., Yonova-Doing E., Knol M.J., Lewis A.J., Judy R.L., Ago T., Amouyel P., Armstrong N.D., Bakker M.K., Bartz T.M., Bennett D.A., Bis J.C., Bordes C., Børte S., Cain A., Ridker P.M., Cho K., Chen Z., Cruchaga C., Cole J.W., de Jager P.L., de Cid R., Endres M., Ferreira L.E., Geerlings M.I., Gasca N.C., Gudnason V., Hata J., He J., Heath A.K., Ho Y.L., Havulinna A.S., Hopewell J.C., Hyacinth H.I., Inouye M., Jacob M.A., Jeon C.E., Jern C., Kamouchi M., Keene K.L., Kitazono T., Kittner S.J., Konuma T., Kumar A., Lacaze P., Launer L.J., Lee K.J., Lepik K., Li J., Li L., Manichaikul A., Markus H.S., Marston N.A., Meitinger T., Mitchell B.D., Montellano F.A., Morisaki T., Mosley T.H., Nalls M.A., Nordestgaard B.G., O’Donnell M.J., Okada Y., Onland-Moret N.C., Ovbiagele B., Peters A., Psaty B.M., Rich S.S.

    Nature   612 ( 7938 )   E7   2022.12   ISSN:00280836

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    In the version of this article initially published, the name of the PRECISE4Q Consortium was misspelled as “PRECISEQ” and has now been amended in the HTML and PDF versions of the article. Further, data in the first column of Supplementary Table 55 were mistakenly shifted and have been corrected in the file accompanying the HTML version of the article.

    DOI: 10.1038/s41586-022-05492-5

    Scopus

    PubMed

  • 嗅覚低下と軽度認知障害および部位別脳萎縮の関連 久山町研究

    三野原 敏文, 小原 知之, 中澤 太郎, 平林 直樹, 秦 淳, 古田 芳彦, 三原 茜, 柴田 舞欧, 中尾 智博, 二宮 利治

    老年精神医学雑誌   33 ( 増刊II )   270 - 270   2022.11   ISSN:0915-6305

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  • 地域高齢住民における領域別脳容積と慢性腰痛の関連 久山町研究

    柴田 舞欧, 浅田 雅子, 平林 直樹, 小原 知之, 古田 芳彦, 中澤 太郎, 本田 貴紀, 秦 淳, 細井 昌子, 二宮 利治, 須藤 信行

    日本心療内科学会誌   26 ( 別冊 )   126 - 126   2022.11   ISSN:1342-9558

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  • 冠動脈疾患の疫学と危険因子

    秦淳、二宮利治

    循環器内科   2022.10

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  • 【冠動脈疾患の一次予防update】冠動脈疾患の疫学と危険因子

    秦 淳, 二宮 利治

    循環器内科   92 ( 4 )   359 - 365   2022.10   ISSN:1884-2909

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    Language:Japanese   Publisher:(有)科学評論社  

  • 嗅覚低下と軽度認知障害および部位別脳萎縮の関連 久山町研究

    三野原 敏文, 小原 知之, 中澤 太郎, 平林 直樹, 秦 淳, 古田 芳彦, 三原 茜, 柴田 舞欧, 中尾 智博, 二宮 利治

    Dementia Japan   36 ( 4 )   763 - 763   2022.10   ISSN:1342-646X

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    Language:Japanese   Publisher:(一社)日本認知症学会  

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  • 日本人地域住民における角膜ヒステリシスと緑内障の関連 久山町研究

    藤原 康太, 上田 瑛美, 橋本 左和子, 中村 駿, 秦 淳, 中野 聡子, 村上 祐介, 久保田 敏昭, 吉冨 健志, 二宮 利治, 園田 康平

    日本緑内障学会抄録集   33回   144 - 144   2022.9

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    Language:Japanese   Publisher:日本緑内障学会  

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  • 地域住民剖検例における皮質領域別の腎組織所見 久山町研究

    丸本 裕和, 佐々木 峻也, 秦 淳, 坪井 伸夫, 小田 義直, 北園 孝成, 横尾 隆, 二宮 利治

    日本腎臓学会誌   64 ( 3 )   224 - 224   2022.5   ISSN:0385-2385 eISSN:1884-0728

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    Language:Japanese   Publisher:(一社)日本腎臓学会  

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  • 地域住民剖検例における血清NT-proBNP値と腎組織所見との関連 久山町研究

    佐々木 峻也, 丸本 裕和, 秦 淳, 坪井 伸夫, 小田 義直, 北園 孝成, 横尾 隆, 二宮 利治

    日本腎臓学会誌   64 ( 3 )   274 - 274   2022.5   ISSN:0385-2385 eISSN:1884-0728

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    Language:Japanese   Publisher:(一社)日本腎臓学会  

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  • 地域高齢住民における大脳白質病変および全脳容積低下が認知症発症に及ぼす影響 久山町研究

    中澤 太郎, 小原 知之, 平林 直樹, 古田 芳彦, 秦 淳, 柴田 舞欧, 本田 貴紀, 北園 孝成, 中尾 智博, 二宮 利治

    精神神経学雑誌   124 ( 4付録 )   S - 367   2022.4   ISSN:0033-2658

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    Language:Japanese   Publisher:(公社)日本精神神経学会  

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  • 【最新臨床脳卒中学(第2版)上-最新の診断と治療-】疫学 久山町研究

    中西 泰之, 秦 淳, 二宮 利治

    日本臨床   80 ( 増刊1 最新臨床脳卒中学(上) )   47 - 52   2022.1   ISSN:0047-1852

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    Language:Japanese   Publisher:(株)日本臨床社  

  • 脳卒中の疫学

    秦淳、二宮利治

    臨牀と研究   2021.12

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 脳梗塞のゲノム疫学研究. Reviewed

    秦 淳、二宮利治

    医学のあゆみ   2021.7

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 脳梗塞のゲノム疫学:久山町研究

    秦 淳、二宮 利治

    Precision Medicine   2021.2

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 脳卒中の疫学

    秦 淳,二宮 利治

    日本臨牀   2019.6

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 脂質異常症と動脈硬化性疾患の疫学研究

    秦 淳,二宮 利治

    CARDIAC PRACTICE   2018.6

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 地域住民における白衣高血圧,仮面高血圧とアルブミン尿症の関連:久山町研究

    秦 淳

    血圧   2018.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 地域住民を対象とした疫学研究

    秦 淳, 小原知之、二宮利治

    日本医師会雑誌 生涯教育シリーズ   2017.6

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 糖代謝異常・脂質異常症と脳卒中の疫学:久山町研究

    秦 淳, 清原 裕

    脳卒中   2016.11

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • ヘマトクリットと心血管病発症の関係:久山町研究

    後藤 聖司, 秦 淳, 清原 裕

    血圧   2016.4

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 脳卒中のバイオマーカー:久山町研究

    秦 淳,清原 裕

    脳卒中   2015.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 糖尿病と認知症の疫学

    秦 淳,清原 裕

    糖尿病診療マスター   2015.8

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 動脈硬化の診断と治療の現況と展望.久山町研究から

    大石絵美,秦 淳,清原 裕

    月刊カレントテラピー   2015.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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Industrial property rights

Patent   Number of applications: 1   Number of registrations: 0
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • American Heart Association

  • Japan Atherosclerosis Society

  • Japan Geriatrics Society

  • Japanese Society of Public Health

  • Japan Epidemiological Association

  • Japan Mibyou Association

  • Japanese Society of Neurology

  • Japanese Society of Hypertension

  • Japanese Society of Cardiovascular Disease Prevention

  • Japanese Circulation Society

  • Japan Stroke Society

  • Japanese Society of Internal Medicine

  • Society for Clinical Epidemiology

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Committee Memberships

  • 日本循環器病予防学会   Councilor   Domestic

    2013.4 - Present   

  • 日本疫学会   代議員   Domestic

    2017.6 - 2025.6   

  • 日本脳卒中学会   Councilor   Domestic

    2018.3 - Present   

  • 日本未病学会   Councilor   Domestic

    2021.11 - Present   

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2024

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:7

  • 座長

    第59回日本循環器病予防学会学術集会  ( Japan ) 2023.6

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    Type:Competition, symposium, etc. 

  • Hypertension Research

    2023.3 - Present

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    Type:Peer review 

  • Screening of academic papers

    Role(s): Peer review

    2023

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:20

  • Screening of academic papers

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:20

    Number of peer-reviewed articles in Japanese journals:1

  • 座長

    第46回日本脳卒中学会学術集会  ( Japan ) 2021.3 - 2021.4

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:9

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:20

  • 実行委員

    日本臨床疫学会第3回年次学術大会  ( Japan ) 2019.9

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2019

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:27

  • Screening of academic papers

    Role(s): Peer review

    2018

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:23

  • 脳卒中

    Role(s): Peer review

    2017.6 - Present

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    Type:Academic society, research group, etc. 

  • 座長(Chairmanship)

    第27回日本老年医学会九州地方会  ( Japan ) 2017.3

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2017

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:21

    Number of peer-reviewed articles in Japanese journals:1

  • 副実行委員長

    第23回日本未病システム学会学術総会  ( Japan ) 2016.11 - 2017.11

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    Type:Competition, symposium, etc. 

  • Journal of Stroke and Cerebrovascular Diseases International contribution

    Role(s): Peer review

    2015.10 - 2019.12

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    Type:Academic society, research group, etc. 

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Research Projects

  • 心電図所見を用いた心房細動・循環器疾患・認知症の発症予測:久山町研究

    2023.4 - 2026.3

    日本 

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    Authorship:Principal investigator 

  • 心電図所見を用いた心房細動・循環器疾患・認知症の発症予測:久山町研究

    Grant number:23K09692  2023 - 2025

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 大規模前向きコホートデータを基盤とした認知症のゲノム・脳画像研究

    2021.4 - 2026.3

    日本 

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    Authorship:Coinvestigator(s) 

  • 腸内細菌叢と生活習慣病・認知症・うつ病発症に関する地域コホート研究:久山町研究

    2021.4 - 2024.3

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    Authorship:Coinvestigator(s) 

  • 大規模前向きコホートデータを基盤とした認知症のゲノム・脳画像研究

    2021 - 2025

    国立研究開発法人日本医療研究開発機構・認知症研究開発事業

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 腸内細菌叢と生活習慣病・認知症・うつ病発症に関する地域コホート研究:久山町研究

    Grant number:21H03200  2021 - 2023

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 地域住民における心房細動発症のバイオマーカーと遺伝要因:久山町研究

    2020.4 - 2023.3

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    Authorship:Principal investigator 

  • 地域住民における心房細動発症のバイオマーカーと遺伝要因:久山町研究

    Grant number:20K10503  2020 - 2022

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 地域高齢住民におけるサルコペニアと認知症発症との関連:久山町研究

    2017.4 - 2020.3

    九州大学(日本) 

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    Authorship:Coinvestigator(s) 

    We investigate the association of sarcopenia with dementia using the follow-up data of the residents of Hisayama, Fukuoka aged 65 years or over.

  • 地域高齢住民におけるサルコペニアと認知症発症との関連:久山町研究

    Grant number:17K01853  2017 - 2019

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 健康長寿社会の実現を目指した大規模認知症コホート研究

    2016.4 - 2021.3

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    Authorship:Coinvestigator(s) 

  • 久山町高齢者におけるMRIを基盤にした認知症・うつ病発症の前向きコホート研究

    2016.4 - 2019.3

    九州大学 

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    Authorship:Coinvestigator(s) 

  • 健康長寿社会の実現を目指した大規模認知症コホート研究

    2016 - 2020

    国立研究開発法人日本医療研究開発機構・認知症研究開発事業

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 久山町高齢者におけるMRIを基盤にした認知症・うつ病発症の前向きコホート研究

    Grant number:16H02644  2016 - 2018

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • NCD-RisC International coauthorship

    2015.12

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

    世界の観察研究を統合したメタ解析

  • MEGASTROKE International coauthorship

    2015.11

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

    世界の脳卒中のゲノムワイド関連解析研究(GWAS)を統合したメタ解析

  • 久山町一般住民におけるむずむず脚症候群と脳心血管病についての検討

    2015.4 - 2018.3

    九州大学 

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    Authorship:Coinvestigator(s) 

  • 健康長寿社会の実現を目指した大規模認知症コホート研究の創設

    2015.4 - 2016.3

    九州大学 

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    Authorship:Coinvestigator(s) 

  • 久山町一般住民におけるむずむず脚症候群と脳心血管病についての検討

    Grant number:15K08737  2015 - 2017

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 健康長寿社会の実現を目指した大規模認知症コホート研究の創設

    2015

    国立研究開発法人日本医療研究開発機構・認知症研究開発事業

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 地域住民における余暇時の運動習慣および運動量が健康寿命に与える影響:久山町研究

    2014.4 - 2017.3

    九州大学 

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    Authorship:Coinvestigator(s) 

  • 日本人地域住民における心房細動の実態と危険因子に関する研究:久山町研究

    2014.4 - 2017.3

    九州大学 

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    Authorship:Principal investigator 

  • 日本人地域住民における心房細動の実態と危険因子に関する研究:久山町研究

    Grant number:26460748  2014 - 2016

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 地域住民における余暇時の運動習慣および運動量が健康寿命に与える影響:久山町研究

    Grant number:26350895  2014 - 2016

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 久山町高齢者におけるMRIを基盤にした脳血管障害,認知症,うつ病の疫学研究

    2013.4 - 2016.3

    九州大学 

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    Authorship:Coinvestigator(s) 

  • 久山町高齢者におけるMRI を基盤にした脳血管障害,認知症,うつ病の疫学研究

    Grant number:25253048  2013 - 2015

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

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Educational Activities

  • Lecture and education at the Department of Health Care Administration and Management.
    Lecture of public health at the Faculty of Medicine.

Class subject

  • 地域包括ケアシステム

    2025.4 - 2026.3   First semester

  • 疫学研究

    2025.4 - 2026.3   First semester

  • 医療保障法

    2024.10 - 2026.3   Second semester

  • 疾病管理学

    2024.10 - 2026.3   Second semester

  • 内科学

    2024.4 - 2025.9   First semester

  • 衛生・公衆衛生学

    2024.4 - 2025.9   First semester

  • 疫学

    2024.4 - 2025.9   First semester

  • 衛生・公衆衛生学

    2017.4 - 2026.3   Full year

  • 医学実習

    2013.8 - 2017.3   Full year

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Outline of Social Contribution and International Cooperation activities

  • 福岡県久山町における生活習慣病予防健診その他の健康・保健事業への医師・公衆衛生学専門家としての協力

Social Activities

  • ストップ!脳卒中~未破裂脳動脈瘤の管理と認知症予防~

    日本脳卒中協会福岡県支部  福岡市  2017.5

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    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 市民公開セミナー ストップ!脳卒中 脈をとり、圧を測り、脳を守る 「圧の測り方、高血圧と脳梗塞予防」

    日本脳卒中協会福岡県支部,ブリストルマイヤーズ株式会社  福岡市  2015.5

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    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

Media Coverage

  • 糖尿病 脳の萎縮進む Newspaper, magazine

    朝日新聞  2016.6

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    糖尿病 脳の萎縮進む

  • 再発しやすい脳卒中 Newspaper, magazine

    共同通信社加盟各紙  2015.6

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    再発しやすい脳卒中

Activities contributing to policy formation, academic promotion, etc.

  • 2023.5 - 2024.3   福岡市保健医療局総務企画部保険医療課

    福岡市特定健診・特定保健指導に関する連絡会議委員

  • 2023.4 - 2025.3   福岡県糟屋郡久山町健康課

    久山町生活習慣病予防対策推進協議会

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Clinical Internal Medicine / Stroke Science

Clinician qualification

  • Specialist

    The Japanese Society of Internal Medicine(JSIM)

  • Certifying physician

    The Japanese Society of Internal Medicine(JSIM)

  • Preceptor

    社会医学系専門医協会

  • Specialist

    社会医学系専門医協会

  • 上席疫学専門家

    日本疫学会

  • Specialist

    The Japan Stroke Society

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Year of medical license acquisition

  • 1998