Updated on 2024/10/07

Information

 

写真a

 
HATA JUN
 
Organization
Faculty of Medical Sciences Department of Basic Medicine Professor
Faculty of Medical Sciences Center for Cohort Studies(Concurrent)
Graduate School of Medical Sciences Department of Medicine(Concurrent)
Graduate School of Medical Sciences Department of Health Care Administration and Management(Concurrent)
Title
Professor
Contact information
メールアドレス
Tel
0926426951
Profile
Lecture and education for master students at the Department of Health Care Administration and Management. Epidemiological studies for chronic diseases (stroke, coronary heart disease, etc.) using the data from the Hisayama Study. Collaboration of epidemiological and clinical studies (in Kyushu University, domestic, and international stidies). Lecture of public health for undergraduate students. Education of epidemiological studies for PhD students.
Homepage

Degree

  • MD, PhD

Research History

  • 2010年1月~2012年12月 シドニー大学 ジョージ国際保健研究所 客員研究員   

Research Interests・Research Keywords

  • Research theme: Epidemiological study for NCDs and senile diseases using the large-scale health data from Fukuoka City residents

    Keyword: Epidemiological study

    Research period: 2024.1

  • Research theme: Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD)

    Keyword: Dementia, depression, cohort study

    Research period: 2015.9

  • Research theme: The Hisayama Study

    Keyword: epidemiology, lifestyle diseases, stroke, coronary heart disease, risk factors

    Research period: 2002.4

Awards

  • Best Reviewers of Hypertension Research 2023

    2024.2   日本高血圧学会  

  • Best Reviewers of Hypertension Research 2022

    2023.1   日本高血圧学会  

  • Circulation Journal Award 2021

    2022.3   日本循環器学会   Risk prediction model for incident atrial fibrillation in a general Japanese population: the Hisayama Study

  • 第25回日本未病システム学会学術総会優秀演題賞

    2018.10   日本未病システム学会   βアラニン血中濃度と認知症発症の関連:久山町研究

  • 第9回Hypertension Research Award

    2018.9   日本高血圧学会   ‘White-coat and masked hypertension are associated with albuminuria in a general population: the Hisayama Study

Papers

  • Risk prediction model for incident atrial fibrillation in a general Japanese population: the Hisayama Study Reviewed

    Hata J, Nagata T, Sakata S, Oishi E, Furuta Y, Hirakawa Y, Honda T, Yoshida D, Kitazono T, Ninomiya T.

    Circ J   2021.7

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    Background: The risk prediction of incident atrial fibrillation (AF) is useful to prevent AF and its complications. The aim of this study is to develop a new risk prediction model for incident AF using the prospective longitudinal data from a general Japanese population.
    Methods and Results: A total of 2,442 community-dwelling AF-free residents aged ≥40 years were followed up from 1988 to 2012 (46,422 person-years). The development of AF was confirmed by a standard 12-lead electrocardiogram at repeated health examinations and by medical records at clinics or hospitals. The risk prediction model for incident AF was developed using a Cox proportional hazards model. During the follow up, 230 AF events were confirmed. Age, sex, systolic blood pressure, waist circumference, estimated glomerular filtration rate, abnormal cardiac murmur, high R-wave amplitude, and arrhythmia other than AF were selected for inclusion in the model. This model showed good discrimination (Harrell's c statistics: 0.785) and calibration (Greenwood-Nam-D'Agostino test: P=0.87) for AF risk at 10 years.
    Conclusions: The new risk prediction model showed good performance on the individual risk assessment of the future onset of AF in a general Japanese population. As this model included commonly used clinical parameters, it may be useful for determining the requirements for the careful evaluation of AF, such as frequent electrocardiogram examinations in clinical settings, and subsequent reductions in the risk of AF-related complications.

    DOI: 10.1253/circj.CJ-20-0794

  • Association between serum β-alanine and risk of dementia Reviewed International journal

    Hata J, Ohara T, Katakura Y, Shimizu K, Yamashita S, Yoshida D, Honda T, Hirakawa Y, Shibata M, Sakata S, Kitazono T, Kuhara S, Ninomiya T.

    Am J Epidemiol   2019.9

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    DOI: 10.1093/aje/kwz116

  • White-coat and masked hypertension are associated with albuminuria in a general population: the Hisayama Study Reviewed

    Hata J, Fukuhara M, Sakata S, Arima H, Hirakawa Y, Yonemoto K, Mukai N, Kitazono T, Kiyohara Y, Ninomiya T.

    Hypertens Res   2017.11

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    DOI: 10.1038/hr.2017.74

  • Risk prediction models for mortality in patients with cardiovascular disease: the BioBank Japan project Reviewed

    Hata J, Nagai A, Hirata M, Kamatani Y, Tamakoshi A, Yamagata Z, Muto K, Matsuda K, Kubo M, Nakamura Y; Biobank Japan Cooperative Hospital Group, Kiyohara Y, Ninomiya T.

    J Epidemiol   2017.3

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    DOI: 10.1016/j.je.2016.10.007

  • Serum angiopoietin-like protein 2 is a novel risk factor for cardiovascular disease in the community: the Hisayama Study Reviewed International journal

    Hata J, Mukai N, Nagata M, Ohara T, Yoshida D, Kishimoto H, Shibata M, Hirakawa Y, Endo M, Ago T, Kitazono T, Oike Y, Kiyohara Y, Ninomiya T.

    Arterioscler Thromb Vasc Biol   2016.8

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    DOI: 10.1161/ATVBAHA.116.307291

  • Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009) Reviewed International journal

    Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y.

    Circulation   2013.9

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    DOI: 10.1161/CIRCULATIONAHA.113.002424

  • Effects of visit-to-visit variability in systolic blood pressure on macrovascular and microvascular complications in patients with type 2 diabetes mellitus: the ADVANCE trial Reviewed International journal

    Hata J, Arima H, Rothwell PM, Woodward M, Zoungas S, Anderson C, Patel A, Neal B, Glasziou P, Hamet P, Mancia G, Poulter N, Williams B, Macmahon S, Chalmers J; ADVANCE Collaborative Group.

    Circulation   2013.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/CIRCULATIONAHA.113.002717

  • Effects of the endpoint adjudication process on the results of a randomised controlled trial: the ADVANCE trial Reviewed International journal

    Hata J, Arima H, Zoungas S, Fulcher G, Pollock C, Adams M, Watson J, Joshi R, Kengne AP, Ninomiya T, Anderson C, Woodward M, Patel A, Mancia G, Poulter N, MacMahon S, Chalmers J, Neal B; ADVANCE Collaborative Group.

    PLoS One   2013.1

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    DOI: 10.1371/journal.pone.0055807

  • Combined effects of smoking and hypercholesterolemia on the risk of stroke and coronary heart disease in Japanese: the Hisayama Study Reviewed International journal

    Hata J, Doi Y, Ninomiya T, Fukuhara M, Ikeda F, Mukai N, Hirakawa Y, Kitazono T, Kiyohara Y.

    Cerebrovasc Dis   2011.1

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    DOI: 10.1159/000324392

  • The effect of metabolic syndrome defined by various criteria on the development of ischemic stroke subtypes in a general Japanese population Reviewed International journal

    Hata J, Doi Y, Ninomiya T, Tanizaki Y, Yonemoto K, Fukuhara M, Kubo M, Kitazono T, Iida M, Kiyohara Y.

    Atherosclerosis   2010.5

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    DOI: 10.1016/j.atherosclerosis.2009.10.044

  • Secular trends in the incidence of and risk factors for ischemic stroke and its subtypes in Japanese population Reviewed International journal

    Kubo M, Hata J, Doi Y, Tanizaki Y, Iida M, Kiyohara Y.

    Circulation   2008.12

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    DOI: 10.1161/CIRCULATIONAHA.107.743211

  • Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction Reviewed International journal

    Hata J, Matsuda K, Ninomiya T, Yonemoto K, Matsushita T, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Iida M, Kiyohara Y, Nakamura Y, Kubo M.

    Hum Mol Genet   2007.3

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    DOI: 10.1093/hmg/ddm005

  • Ten year recurrence after first ever stroke in a Japanese community: the Hisayama Study Reviewed International journal

    Hata J, Tanizaki Y, Kiyohara Y, Kato I, Kubo M, Tanaka K, Okubo K, Nakamura H, Oishi Y, Ibayashi S, Iida M.

    J Neurol Neurosurg Psychiatry   2005.3

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    DOI: 10.1136/jnnp.2004.038166

  • Autonomic nervous system function assessed by heart rate variability and the presence of symptoms affecting activities of daily living in community-dwelling residents with chronic pain: The Hisayama Study. International journal

    Yuri Nakamura, Mao Shibata, Yukiko Morisaki, Naoki Hirabayashi, Mayu Higashioka, Jun Hata, Masako Hosoi, Nobuyuki Sudo, Ken Yamaura, Toshiharu Ninomiya

    European journal of pain (London, England)   28 ( 5 )   831 - 844   2024.5

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    BACKGROUND: Autonomic nervous system dysfunction has been reported to be associated with impaired activities of daily living (ADL) among patients with chronic pain, but the association has not been fully addressed in general populations. This study cross-sectionally investigated the association between autonomic nervous system function and the presence of subjective symptoms affecting ADL in community-dwelling residents with chronic pain. METHODS: A total of 888 residents with chronic pain, aged 40-79 years, who underwent a health examination in 2017-2018 were included. Based on heart rate variability measured by fingertip pulse wave, the standard deviation of normal-to-normal intervals (SDNN), root mean square of successive RR interval differences (RMSSD), low frequency (LF) power, and high frequency (HF) power were calculated. Symptoms affecting ADL were defined as those scoring ≥1 on the modified Rankin Scale. Odds ratios (ORs) and their 95% confidence intervals (CIs) for symptoms affecting ADL were estimated using a logistic regression analysis. RESULTS: The overall prevalence of symptoms affecting ADL was 39.4%. The ORs for symptoms affecting ADL increased significantly per 1-standard-deviation decrement in log-transformed SDNN (OR 1.23 [95% CI 1.06-1.44]), RMSSD (1.25 [1.08-1.45]), LF power (1.29 [1.11-1.52]), and HF power (1.29 [1.11-1.51]) after adjusting for age, sex, education, hypertension, diabetes, serum total cholesterol level, body mass index, past medical history, current smoking, current drinking, exercise, depressive symptoms, and pain intensity. CONCLUSIONS: Decreased heart rate variability was associated with the presence of symptoms affecting ADL among individuals with chronic pain in a Japanese community. SIGNIFICANCE: Decrease in heart rate variability was associated with the presence of symptoms affecting ADL among individuals with chronic pain in a Japanese community. This article could help scientists understand the significance of autonomic nervous system dysfunction in the pathology of chronic pain. Approaches that target autonomic nervous system dysfunction may be an option to relieve or prevent symptoms affecting ADL for chronic pain sufferers.

    DOI: 10.1002/ejp.2224

  • Serum high-sensitivity C-reactive protein and dementia in a community-dwelling Japanese older population (JPSC-AD) Reviewed

    Tachibana A, Iga JI, Ozaki T, Yoshida T, Yoshino Y, Shimizu H, Mori T, Furuta Y, Shibata M, Ohara T, Hata J, Taki Y, Mikami T, Maeda T, Ono K, Mimura M, Nakashima K, Takebayashi M, Ninomiya T, Ueno SI; JPSC-AD study group

    Sci Rep   14 ( 1 )   7374   2024.3

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    DOI: 10.1038/s41598-024-57922-1

  • Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults Reviewed International coauthorship

    NCD Risk Factor Collaboration (NCD-RisC)

    Lancet   403 ( 10431 )   1027 - 1050   2024.3

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    DOI: 10.1016/S0140-6736(23)02750-2

  • Association between Vascular Calcification and Intraplaque Hemorrhage in Coronary Atherosclerosis from Autopsy: The Hisayama Study.

    Toshiaki Nakano, Hiromasa Kitamura, Jun Hata, Kenji Maki, Yoshinao Oda, Takanari Kitazono, Toshiharu Ninomiya

    Journal of atherosclerosis and thrombosis   31 ( 8 )   1225 - 1237   2024.3   ISSN:13403478 eISSN:18803873

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japan Atherosclerosis Society  

    <p> <b>Aims:</b> Vascular calcification is observed in advanced atherosclerotic lesions. Vascular calcification is considered to increase the risk of intraplaque hemorrhage and subsequent plaque destabilization; however, there is limited pathohistoological evidence of the association between vascular calcification and intraplaque hemorrhage. The aim of this study was to investigate the association between vascular calcification and intraplaque hemorrhage in the coronary arteries.</p><p> <b>Methods:</b> We examined 374 coronary arteries obtained from the autopsy samples of 126 deceased individuals. The vascular calcification levels of each artery were categorized into no calcification and quintiles of calcification area size among the arteries with calcification. Macrophage infiltration and neovascularization were also evaluated. The association of the calcification area, macrophage area, or number of vessels with the presence of intraplaque hemorrhage in the coronary arteries was estimated using a logistic regression analysis.</p><p><b>Results:</b> Calcification lesions were observed in 149 coronary arteries. Arteries in the fourth quintile of calcification area size had a significantly greater likelihood of intraplaque hemorrhage than the arteries without calcification, after adjusting for confounders: odds ratio 13.13 (95% confidence interval: 2.97–58.16). After evaluating the influence of macrophage infiltration, the highest odds ratio of intraplaque hemorrhage was associated with the combination of large macrophage area and moderately sized calicification areas. The odds ratio of intraplaque hemorrhage additively increased with the combination of calcification and the number of vessels.</p><p><b>Conclusions:</b> The present findings suggest that vascular calcification is significantly associated with intraplaque hemorrhage. The association between vascular calcification and intraplaque hemorrhage may decrease above a certain size of the calcification area.</p>

    DOI: 10.5551/jat.64394

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  • Association between corneal hysteresis and glaucoma in a Japanese population: the Hisayama Study. International journal

    Kohta Fujiwara, Emi Ueda, Jun Hata, Satoko Nakano, Sawako Hashimoto, Shun Nakamura, Yusuke Murakami, Toshiaki Kubota, Takeshi Yoshitomi, Toshiharu Ninomiya, Koh-Hei Sonoda

    The British journal of ophthalmology   2024.3

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    AIMS: To investigate the association between corneal hysteresis and the presence of glaucoma and its subtypes in a general Japanese population. METHODS: We analysed the data of 2338 Japanese community-dwellers aged ≥40 years (1059 men, 1279 women) who underwent an eye examination in 2018 as part of the population-based, cross-sectional Hisayama Study. Participants were divided into quartile levels of corneal hysteresis, which had been measured with an ocular response analyzer. Glaucoma was defined based on the International Society of Geographical and Epidemiological Ophthalmology criteria. We conducted a logistic regression analysis to determine the ORs and their 95&#37; CIs for the presence of outcomes according to the corneal hysteresis quartiles. RESULTS: Glaucoma was diagnosed in 154 participants: primary open-angle glaucoma (POAG), n=115; primary angle-closure glaucoma, n=17; exfoliation glaucoma, n=21 and secondary glaucoma without exfoliation glaucoma, n=1. After adjustment for confounders, the OR for prevalent glaucoma was significantly increased in the participants in the first corneal-hysteresis quartile compared with those in the fourth quartile (OR: 1.80; 95&#37; CI: 1.03 to 3.17). Regarding glaucoma subtypes, the first-quartile participants had significantly greater likelihoods of the presence of POAG (OR: 1.63; 95&#37; CI: 1.02 to 2.61) and exfoliation glaucoma (OR: 6.49; 95&#37; CI: 1.44 to 29.30) compared with those in the third and fourth quartiles after adjustment for potential confounders. CONCLUSIONS: These results demonstrated a significant inverse association between corneal hysteresis and the likelihood of glaucoma, suggesting that the measurement of corneal hysteresis would provide useful information for elucidating the aetiology of glaucoma.

    DOI: 10.1136/bjo-2023-323987

  • Longitudinal association of sedentary time with diabetes mellitus and markers of glucose metabolism in middle-aged and older adults: the Hisayama Study Reviewed

    Tsuda S, Honda T, Higashioka M, Hata J, Nakano T, Kitazono T, Ninomiya T

    J Diabetes Investig   15 ( 2 )   245 - 246   2024.2

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    DOI: 10.1111/jdi.14096

  • Serum lipopolysaccharide-binding protein levels and the incidence of metabolic syndrome in a general Japanese population: the Hisayama Study Reviewed

    Tomooka S, Oishi E, Asada M, Sakata S, Hata J, Chen S, Honda T, Suzuki K, Watanabe H, Murayama N, Wada N, Kitazono T, Ninomiya T.

    J Epidemiol   2024.1

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    DOI: 10.2188/jea.JE20220232

  • Late-life high blood pressure and enlarged perivascular spaces in the putaminal regions of community-dwelling Japanese plder persons. Reviewed International journal

    Tachibana A, Iga JI, Tatewaki Y, Thyreau B, Chen H, Ozaki T, Yoshida T, Yoshino Y, Shimizu H, Mori T, Furuta Y, Shibata M, Ohara T, Hata J, Taki Y, Nakaji S, Maeda T, Ono K, Mimura M, Nakashima K, Takebayashi M, Ninomiya T, Ueno SI; JPSC-AD study group.

    J Geriatr Psychiatry Neurol   37 ( 1 )   61 - 72   2024.1

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    BACKGROUND: Enlarged perivascular spaces (EPVS) of the brain may be involved in dementia, such as Alzheimer's disease and cerebral small vessel disease (CSVD). Hypertension has been reported to be a risk factor for dementia and CSVD, but the association between blood pressure (BP) and perivascular spaces is still unclear. The aim of this study was to determine the association between BP and EPVS volumes and to examine the interactions of relevant factors. METHODS: A total of 9296 community-dwelling subjects aged ≥65 years participated in a brain magnetic resonance imaging and health status screening examination. Perivascular volume was measured using a software package based on deep learning that was developed in-house. The associations between BP and EPVS volumes were examined by analysis of covariance and multiple regression analysis. RESULTS: Mean EPVS volumes increased significantly with rising systolic and diastolic BP levels (P for trend = .003, P for trend<.001, respectively). In addition, mean EPVS volumes increased significantly for every 1-mmHg-increment in systolic and diastolic BPs (both P values <.001). These significant associations were still observed in the sensitivity analysis after excluding subjects with dementia. CONCLUSIONS: The present data suggest that higher systolic and diastolic BP levels are associated with greater EPVS volumes in cognitively normal older people.

    DOI: 10.1177/08919887231195235

  • Development and validation of a risk pediction model for atherosclerotic cardiovascular disease in Japanese adults: the Hisayama Study Reviewed

    Honda T, Chen S, Hata J, Yoshida D, Hirakawa Y, Furuta Y, Shibata M, Sakata S, Kitazono T, Ninomiya T

    J Atheroscler Thromb   30 ( 12 )   1966 - 1967   2023.12

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    DOI: 10.5551/jat.ER61960

  • Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

    Bin Zhou, Kate E. Sheffer, James E. Bennett, Edward W. Gregg, Goodarz Danaei, Rosie K. Singleton, Jonathan E. Shaw, Anu Mishra, Victor P. F. Lhoste, Rodrigo M. Carrillo-Larco, Andre P. Kengne, Nowell H. Phelps, Rachel A. Heap, Archie W. Rayner, Gretchen A. Stevens, Chris J. Paciorek, Leanne M. Riley, Melanie J. Cowan, Stefan Savin, Stephen Vander Hoorn, Yuan Lu, Meda E. Pavkov, Giuseppina Imperatore, Carlos A. Aguilar-Salinas, Noor Ani Ahmad, Ranjit Mohan Anjana, Kairat Davletov, Farshad Farzadfar, Clicerio González-Villalpando, Young-Ho Khang, Hyeon Chang Kim, Tiina Laatikainen, Avula Laxmaiah, Jean Claude N. Mbanya, K. M. Venkat Narayan, Ambady Ramachandran, Alisha N. Wade, Tomasz Zdrojewski, Mohsen Abbasi-Kangevari, Hanan F. Abdul Rahim, Niveen M. Abu-Rmeileh, Shalkar Adambekov, Robert J. Adams, Wichai Aekplakorn, Imelda A. Agdeppa, Javad Aghazadeh-Attari, Charles Agyemang, Ali Ahmadi, Naser Ahmadi, Nastaran Ahmadi, Soheir H. Ahmed, Kamel Ajlouni, Halima Al-Hinai, Badreya Al-Lahou, Jawad A. Al-Lawati, Deena Al Asfoor, Nawal M. Al Qaoud, Monira Alarouj, Fadia AlBuhairan, Shahla AlDhukair, Maryam A. Aldwairji, Mohamed M. Ali, Farbod Alinezhad, Abdullah Alkandari, Husam F. Alomirah, Eman Aly, Deepak N. Amarapurkar, Lars Bo Andersen, Sigmund A. Anderssen, Dolores S. Andrade, Alireza Ansari-Moghaddam, Hajer Aounallah-Skhiri, Tahir Aris, Nimmathota Arlappa, Krishna K. Aryal, Felix K. Assah, Batyrbek Assembekov, Juha Auvinen, Mária Avdičová, Kishwar Azad, Mohsen Azimi-Nezhad, Fereidoun Azizi, Flora Bacopoulou, Nagalla Balakrishna, Mohamed Bamoshmoosh, Maciej Banach, Piotr Bandosz, José R. Banegas, Carlo M. Barbagallo, Alberto Barceló, Maja Baretić, Lena Barrera, Abdul Basit, Anwar M. Batieha, Aline P. Batista, Louise A. Baur, Antonisamy Belavendra, Habiba Ben Romdhane, Mikhail Benet, Salim Berkinbayev, Antonio Bernabe-Ortiz, Ximena Berrios Carrasola, Heloísa Bettiol, Augustin F. Beybey, Santosh K. Bhargava, Elysée Claude Bika Lele, Mukharram M. Bikbov, Bihungum Bista, Peter Bjerregaard, Espen Bjertness, Marius B. Bjertness, Cecilia Björkelund, Katia V. Bloch, Anneke Blokstra, Simona Bo, Martin Bobak, Jose G. Boggia, Marialaura Bonaccio, Alice Bonilla-Vargas, Herman Borghs, Pascal Bovet, Imperia Brajkovich, Hermann Brenner, Lizzy M. Brewster, Garry R. Brian, Yajaira Briceño, Miguel Brito, Anna Bugge, Frank Buntinx, Antonio Cabrera de León, Roberta B. Caixeta, Günay Can, Ana Paula C. Cândido, Mario V. Capanzana, Naděžda Čapková, Eduardo Capuano, Rocco Capuano, Vincenzo Capuano, Viviane C. Cardoso, Axel C. Carlsson, Felipe F. Casanueva, Laura Censi, Marvin Cervantes‐Loaiza, Parinya Chamnan, Snehalatha Chamukuttan, Queenie Chan, Fadi J. Charchar, Nish Chaturvedi, Huashuai Chen, Bahman Cheraghian, María-Dolores Chirlaque, Jerzy Chudek, Renata Cifkova, Massimo Cirillo, Frank Claessens, Emmanuel Cohen, Hans Concin, Cyrus Cooper, Simona Costanzo, Chris Cowell, Ana B. Crujeiras, Juan J. Cruz, Felipe V. Cureau, Sarah Cuschieri, Graziella D’Arrigo, Eleonora d’Orsi, Jean Dallongeville, Albertino Damasceno, Saeed Dastgiri, Amalia De Curtis, Giovanni de Gaetano, Stefaan De Henauw, Mohan Deepa, Vincent DeGennaro, Stefaan Demarest, Elaine Dennison, Valérie Deschamps, Meghnath Dhimal, Zivka Dika, Shirin Djalalinia, Chiara Donfrancesco, Guanghui Dong, Maria Dorobantu, Marcus Dörr, Nico Dragano, Wojciech Drygas, Yong Du, Charmaine A. Duante, Priscilla Duboz, Anar Dushpanova, Elzbieta Dziankowska-Zaborszczyk, Narges Ebrahimi, Ricky Eddie, Ebrahim Eftekhar, Vasiliki Efthymiou, Eruke E. Egbagbe, Sareh Eghtesad, Mohammad El-Khateeb, Jalila El Ati, Denise Eldemire-Shearer, Roberto Elosua, Ofem Enang, Rajiv T. Erasmus, Raimund Erbel, Cihangir Erem, Gul Ergor, Louise Eriksen, Johan G. Eriksson, Ali Esmaeili, Roger G. Evans, Ildar Fakhradiyev, Caroline H. Fall, Elnaz Faramarzi, Mojtaba Farjam, Yosef Farzi, Mohammad Reza Fattahi, Asher Fawwad, Francisco J. Felix-Redondo, Trevor S. Ferguson, Daniel Fernández-Bergés, Marika Ferrari, Catterina Ferreccio, Haroldo S. Ferreira, Eldridge Ferrer, Edith J. M. Feskens, David Flood, Maria Forsner, Sandrine Fosse, Edward F. Fottrell, Heba M. Fouad, Damian K. Francis, Guillermo Frontera, Takuro Furusawa, Zbigniew Gaciong, Sarah P. Garnett, Magda Gasull, Andrea Gazzinelli, Ulrike Gehring, Ebrahim Ghaderi, Seyyed-Hadi Ghamari, Ali Ghanbari, Erfan Ghasemi, Oana-Florentina Gheorghe-Fronea, Anup Ghimire, Alessandro Gialluisi, Simona Giampaoli, Francesco Gianfagna, Tiffany K. Gill, Glen Gironella, Aleksander Giwercman, David Goltzman, Aleksandra Gomula, Helen Gonçalves, Mauer Gonçalves, David A. Gonzalez-Chica, Marcela Gonzalez-Gross, Juan P. González-Rivas, María-Elena González-Villalpando, Angel R. Gonzalez, Frederic Gottrand, Dušan Grafnetter, Tomasz Grodzicki, Anders Grøntved, Ramiro Guerrero, Unjali P. Gujral, Rajeev Gupta, Laura Gutierrez, Xinyi Gwee, Rosa Haghshenas, Hamid Hakimi, Ian R. Hambleton, Behrooz Hamzeh, Willem A. Hanekom, Dominique Hange, Sari Hantunen, Jie Hao, Rachakulla Hari Kumar, Javad Harooni, Seyed Mohammad Hashemi-Shahri, Jun Hata, Christin Heidemann, Rafael dos Santos Henrique, Sauli Herrala, Karl-Heinz Herzig, Ramin Heshmat, Sai Yin Ho, Michelle Holdsworth, Reza Homayounfar, Wilma M. Hopman, Andrea R. V. R. Horimoto, Claudia Hormiga, Bernardo L. Horta, Leila Houti, Christina Howitt, Thein Thein Htay, Aung Soe Htet, Maung Maung Than Htike, José María Huerta, Ilpo Tapani Huhtaniemi, Martijn Huisman, Abdullatif Husseini, Inge Huybrechts, Licia Iacoviello, Ellina M. Iakupova, Anna G. Iannone, Norazizah Ibrahim Wong, Chinwuba Ijoma, Vilma E. Irazola, Takafumi Ishida, Godsent C. Isiguzo, Sheikh Mohammed Shariful Islam, Duygu Islek, Till Ittermann, Masanori Iwasaki, Tuija Jääskeläinen, Jeremy M. Jacobs, Hashem Y. Jaddou, Michel Jadoul, Bakary Jallow, Kenneth James, Kazi M. Jamil, Edward Janus, Marjo-Riitta Jarvelin, Grazyna Jasienska, Ana Jelaković, Bojan Jelaković, Garry Jennings, Anjani Kumar Jha, Ramon O. Jimenez, Karl-Heinz Jöckel, Jari J. Jokelainen, Jost B. Jonas, Pradeep Joshi, Josipa Josipović, Farahnaz Joukar, Jacek Jóźwiak, Anthony Kafatos, Eero O. Kajantie, Zhanna Kalmatayeva, Khem B. Karki, Marzieh Katibeh, Jussi Kauhanen, Gyulli M. Kazakbaeva, François F. Kaze, Calvin Ke, Sirkka Keinänen-Kiukaanniemi, Roya Kelishadi, Maryam Keramati, Mathilde Kersting, Yousef Saleh Khader, Arsalan Khaledifar, Davood Khalili, Bahareh Kheiri, Motahareh Kheradmand, Alireza Khosravi, Ursula Kiechl-Kohlendorfer, Sophia J. Kiechl, Stefan Kiechl, Andrew Kingston, Heidi Klakk, Jana Klanova, Michael Knoflach, Patrick Kolsteren, Jürgen König, Raija Korpelainen, Paul Korrovits, Jelena Kos, Seppo Koskinen, Sudhir Kowlessur, Slawomir Koziel, Susi Kriemler, Peter Lund Kristensen, Daan Kromhout, Ruzena Kubinova, Urho M. Kujala, Mukhtar Kulimbet, Pawel Kurjata, Catherine Kyobutungi, Quang Ngoc La, Demetre Labadarios, Carl Lachat, Youcef Laid, Lachmie Lall, Tiina Lankila, Vera Lanska, Georg Lappas, Bagher Larijani, Tint Swe Latt, Martino Laurenzi, Nils Lehmann, Terho Lehtimäki, Daniel Lemogoum, Gabriel M. Leung, Yanping Li, M. Fernanda Lima-Costa, Hsien-Ho Lin, Lars Lind, Lauren Lissner, Xiaotian Liu, Esther Lopez-Garcia, Tania Lopez, José Eugenio Lozano, Dalia Luksiene, Annamari Lundqvist, Nuno Lunet, Michala Lustigová, George L. L. Machado-Coelho, Aristides M. Machado-Rodrigues, Enguerran Macia, Luisa M. Macieira, Ahmed A. Madar, Gladys E. Maestre, Stefania Maggi, Dianna J. Magliano, Emmanuella Magriplis, Gowri Mahasampath, Bernard Maire, Marcia Makdisse, Mohammad-Reza Malekpour, Fatemeh Malekzadeh, Reza Malekzadeh, Kodavanti Mallikharjuna Rao, Sofia Malyutina, Lynell V. Maniego, Yannis Manios, Masimango Imani Mannix, Fariborz Mansour-Ghanaei, Enzo Manzato, Paula Margozzini, Joany Mariño, Larissa Pruner Marques, Reynaldo Martorell, Luis P. Mascarenhas, Masoud Masinaei, Ellisiv B. Mathiesen, Tandi E. Matsha, Anselmo J. Mc Donald Posso, Shelly R. McFarlane, Stephen T. McGarvey, Sounnia Mediene Benchekor, Kirsten Mehlig, Amir Houshang Mehrparvar, Jesus D. Melgarejo, Fabián Méndez, Ana Maria B. Menezes, Alibek Mereke, Indrapal I. Meshram, Diane T. Meto, Cláudia S. Minderico, G. K. Mini, Juan Francisco Miquel, J. Jaime Miranda, Mohammad Reza Mirjalili, Pietro A. Modesti, Sahar Saeedi Moghaddam, Mostafa K. Mohamed, Kazem Mohammad, Mohammad Reza Mohammadi, Zahra Mohammadi, Noushin Mohammadifard, Reza Mohammadpourhodki, Viswanathan Mohan, Muhammad Fadhli Mohd Yusoff, Iraj Mohebbi, Niels C. Møller, Dénes Molnár, Amirabbas Momenan, Charles K. Mondo, Roger A. Montenegro Mendoza, Eric Monterrubio-Flores, Mahmood Moosazadeh, Farhad Moradpour, Alain Morejon, Luis A. Moreno, Karen Morgan, Suzanne N. Morin, Alireza Moslem, Mildrey Mosquera, Malgorzata Mossakowska, Aya Mostafa, Seyed-Ali Mostafavi, Mohammad Esmaeel Motlagh, Jorge Motta, Kelias P. Msyamboza, Thet Thet Mu, Maria L. Muiesan, Jaakko Mursu, Kamarul Imran Musa, Norlaila Mustafa, Muel Telo M. C. Muyer, Iraj Nabipour, Gabriele Nagel, Balkish M. Naidu, Farid Najafi, Jana Námešná, Vinay B. Nangia, Take Naseri, Nareemarn Neelapaichit, Azim Nejatizadeh, Ilona Nenko, Flavio Nervi, Tze Pin Ng, Chung T. Nguyen, Quang Ngoc Nguyen, Michael Y. Ni, Peng Nie, Ramfis E. Nieto-Martínez, Toshiharu Ninomiya, Marianna Noale, Oscar A. Noboa, Davide Noto, Mohannad Al Nsour, Irfan Nuhoğlu, Terence W. O’Neill, Augustine N. Odili, Kyungwon Oh, Ryutaro Ohtsuka, Mohd Azahadi Omar, Altan Onat, Sok King Ong, Obinna Onodugo, Pedro Ordunez, Rui Ornelas, Pedro J. Ortiz, Clive Osmond, Afshin Ostovar, Johanna A. Otero, Charlotte B. Ottendahl, Akaninyene Otu, Ellis Owusu-Dabo, Luigi Palmieri, Wen-Harn Pan, Songhomitra Panda-Jonas, Francesco Panza, Mariela Paoli, Suyeon Park, Mahboubeh Parsaeian, Nikhil D. Patel, Raimund Pechlaner, Ivan Pećin, João M. Pedro, Sergio Viana Peixoto, Markku Peltonen, Alexandre C. Pereira, Thaliane Mayara Pessôa dos Prazeres, Niloofar Peykari, Modou Cheyassin Phall, Son Thai Pham, Hiep Hoang Phan, Rafael N. Pichardo, Hynek Pikhart, Aida Pilav, Pavel Piler, Freda Pitakaka, Aleksandra Piwonska, Andreia N. Pizarro, Pedro Plans-Rubió, Silvia Plata, Miquel Porta, Anil Poudyal, Farhad Pourfarzi, Akram Pourshams, Hossein Poustchi, Rajendra Pradeepa, Rui Providencia, Jardena J. Puder, Solie Puhakka, Margus Punab, Mostafa Qorbani, Hedley K. Quintana, Tran Quoc Bao, Salar Rahimikazerooni, Olli Raitakari, Manuel Ramirez-Zea, Jacqueline Ramke, Rafel Ramos, Lekhraj Rampal, Sanjay Rampal, Daniel A. Rangel Reina, Mohammad-Mahdi Rashidi, Josep Redon, Jane D. P. Renner, Cézane P. Reuter, Luis Revilla, Negar Rezaei, Abbas Rezaianzadeh, Fernando Rigo, Reina G. Roa, Louise Robinson, Fernando Rodríguez-Artalejo, María del Cristo Rodriguez-Perez, Laura A. Rodríguez-Villamizar, Andrea Y. Rodríguez, Ulla Roggenbuck, Peter Rohloff, Elisabetta L. Romeo, Annika Rosengren, Adolfo Rubinstein, Petra Rust, Marcin Rutkowski, Hamideh Sabbaghi, Harshpal S. Sachdev, Alireza Sadjadi, Ali Reza Safarpour, Sare Safi, Saeid Safiri, Mohammad Hossien Saghi, Olfa Saidi, Nader Saki, Sanja Šalaj, Benoit Salanave, Jukka T. Salonen, Massimo Salvetti, Jose Sánchez-Abanto, Diana A. Santos, Lèlita C. Santos, Maria Paula Santos, Tamara R. Santos, Jouko L. Saramies, Luis B. Sardinha, Nizal Sarrafzadegan, Kai-Uwe Saum, Mariana Sbaraini, Marcia Scazufca, Beatriz D. Schaan, Christa Scheidt-Nave, Sabine Schipf, Carsten O. Schmidt, Ben Schöttker, Sara Schramm, Sylvain Sebert, Moslem Sedaghattalab, Aye Aye Sein, Sadaf G. Sepanlou, Ronel Sewpaul, Teresa Shamah-Levy, Seyed Morteza Shamshirgaran, Maryam Sharafkhah, Sanjib K. Sharma, Almaz Sharman, Amaneh Shayanrad, Ali Akbar Shayesteh, Hana Shimizu-Furusawa, Rahman Shiri, Namuna Shrestha, Khairil Si-Ramlee, Diego Augusto Santos Silva, Mary Simon, Judith Simons, Leon A. Simons, Michael Sjöström, Jolanta Slowikowska-Hilczer, Przemysław Slusarczyk, Liam Smeeth, Eugène Sobngwi, Stefan Söderberg, Agustinus Soemantri, Reecha Sofat, Vincenzo Solfrizzi, Mohammad Hossein Somi, Aïcha Soumaré, Alfonso Sousa-Poza, Karen Sparrenberger, Jan A. Staessen, Bill Stavreski, Jostein Steene-Johannessen, Peter Stehle, Aryeh D. Stein, Jochanan Stessman, Jakub Stokwiszewski, Karien Stronks, Milton F. Suarez-Ortegón, Phalakorn Suebsamran, Johan Sundström, Paibul Suriyawongpaisal, René Charles Sylva, Moyses Szklo, Abdonas Tamosiunas, Mohammed Rasoul Tarawneh, Carolina B. Tarqui-Mamani, Anne Taylor, Julie Taylor, Tania Tello, K. R. Thankappan, Holger Theobald, Xenophon Theodoridis, Nihal Thomas, Amanda G. Thrift, Erik J. Timmermans, Dwi Hapsari Tjandrarini, Hanna K. Tolonen, Janne S. Tolstrup, Maciej Tomaszewski, Murat Topbas, Laura Torres-Collado, Pierre Traissac, Areti Triantafyllou, John Tuitele, Azaliia M. Tuliakova, Marshall K. Tulloch-Reid, Tomi-Pekka Tuomainen, Evangelia Tzala, Christophe Tzourio, Peter Ueda, Eunice Ugel, Flora A. M. Ukoli, Hanno Ulmer, Hannu M. T. Uusitalo, Gonzalo Valdivia, Bert-Jan van den Born, Johan Van der Heyden, Hoang Van Minh, Lenie van Rossem, Natasja M. Van Schoor, Irene G. M. van Valkengoed, Elisabeth M. van Zutphen, Dirk Vanderschueren, Diego Vanuzzo, Senthil K. Vasan, Tomas Vega, Gustavo Velasquez-Melendez, Roosmarijn Verstraeten, Lucie Viet, Salvador Villalpando, Jesus Vioque, Jyrki K. Virtanen, Bharathi Viswanathan, Ari Voutilainen, Wan Mohamad Wan Bebakar, Wan Nazaimoon Wan Mohamud, Chongjian Wang, Ningli Wang, Qian Wang, Ya Xing Wang, Ying-Wei Wang, S. Goya Wannamethee, Karen Webster-Kerr, Niels Wedderkopp, Wenbin Wei, Leo D. Westbury, Peter H. Whincup, Kurt Widhalm, Indah S. Widyahening, Andrzej Więcek, Rainford J. Wilks, Johann Willeit, Peter Willeit, Tom Wilsgaard, Bogdan Wojtyniak, Andrew Wong, Emily B. Wong, Mark Woodward, Frederick C. Wu, Haiquan Xu, Liang Xu, Nor Azwany Yaacob, Li Yan, Weili Yan, Moein Yoosefi, Akihiro Yoshihara, Novie O. Younger-Coleman, Yu-Ling Yu, Yunjiang Yu, Ahmad Faudzi Yusoff, Ahmad A. Zainuddin, Farhad Zamani, Sabina Zambon, Antonis Zampelas, Ko Ko Zaw, Tajana Zeljkovic Vrkic, Yi Zeng, Zhen-Yu Zhang, Bekbolat Zholdin, Paul Zimmet, Emanuel Zitt, Nada Zoghlami, Julio Zuñiga Cisneros, Majid Ezzati

    Nature Medicine   2023.11

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    Abstract

    Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening, had elevated FPG, HbA1c or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardized proportion of diabetes that was previously undiagnosed and detected in survey screening ranged from 30&#37; in the high-income western region to 66&#37; in south Asia. Among those with screen-detected diabetes with either test, the age-standardized proportion who had elevated levels of both FPG and HbA1c was 29–39&#37; across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c was more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global shortfall in diabetes diagnosis and surveillance.

    DOI: 10.1038/s41591-023-02610-2

  • Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation Reviewed International coauthorship

    Emerging Risk Factors Collaboration

    Lancet Diabetes Endocrinol   11 ( 10 )   731 - 742   2023.10

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    DOI: 10.1016/S2213-8587(23)00223-1

  • Gender and age influence the association between gait speed and mild cognitive impairment in community‐dwelling Japanese older adults: from the Japan Prospective Studies Collaboration for Ageing and Dementia (JPSC‐AD) Reviewed International journal

    Shogyoku Bun, Kouta Suzuki, Hidehito Niimura, Ryo Shikimoto, Hisashi Kida, Mao Shibata, Takanori Honda, Tomoyuki Ohara, Jun Hata, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Kenji Nakashima, Jun‐ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya, Masaru Mimura

    Psychogeriatrics   2023.8

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    Background

    Studies have shown that decreased gait speed is associated with impaired cognitive function. However, whether this association is equivalent across ages or genders in the older population remains unclear. Thus, we examined the association between mild cognitive impairment (MCI) and gait speed emphasising the influence of age and gender.

    Methods

    Overall, 8233 Japanese participants aged ≥65 years were enrolled in this cross‐sectional study between 2016 and 2018. After stratification by gender and age group, the participants' gait speeds were divided into quintiles, and the difference in MCI prevalence at each gait speed quintile was calculated. Logistic regression analyses were performed to assess the odds of MCI for each quintile and to assess the influence of age and gender.

    Results

    Males had a consistently higher prevalence of MCI than females. The odds of MCI were increased as gait speed decreased. Logistic regression analyses revealed that in the multivariable‐adjusted model 2, the odds ratios (95% confidence interval; CI) for MCI were 2.02 (1.47–2.76) for females and 1.75 (1.29–2.38) for males in the slowest gait speed quintiles compared to the fastest quintile. In the stratified analyses, only males showed an age‐dependent increase in the associations between gait speed and MCI, while females exhibited comparable associations across age groups.

    Conclusions

    Reduced gait speed was associated with increased odds of MCI, and this association may vary according to gender and age. Therefore, gait speed could serve as a valuable screening tool for MCI, with gender‐ and age‐dependent clinical implications.

    DOI: 10.1111/psyg.13013

  • Association between frequency of social contact and brain atrophy in community-dwelling older people without dementia: the JPSC-AD Study. Reviewed International journal

    Naoki Hirabayashi, Takanori Honda, Jun Hata, Yoshihiko Furuta, Mao Shibata, Tomoyuki Ohara, Yasuko Tatewaki, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya

    Neurology   2023.7

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    BACKGROUND AND OBJECTIVES: Epidemiological evidence has shown that social isolation, a low frequency of social contact with others, is associated with the risk of dementia and late-life depressive symptoms. Therefore, we hypothesized that low frequency of social contact may be involved in brain atrophy, and depressive symptoms may play some role in this relationship. We aimed to evaluate the association between low frequency of social contact and the volumes of various brain regions and to assess the extent to which depressive symptoms mediate these relationships from a large population-based multisite cohort study. METHODS: Dementia-free community-dwelling Japanese aged ≥65 years underwent brain MRI scans and a comprehensive health examination. Frequency of contact with non-cohabiting relatives and friends was determined by asking a single question with four categories: everyday, several times a week, several times a month, and seldom. Total and regional brain volumes, intracranial volume (ICV) and white matter lesions volume were estimated using FreeSurfer software. The associations between frequency of social contact and brain volumes per ICV were examined using analyses of covariance. Mediation analyses were conducted to calculate the proportion of the associations explained by depressive symptoms. RESULTS: We included 8,896 participants. The multivariable-adjusted mean of the total brain volume in the group with the lowest frequency of social contact was significantly lower compared to that in the group with the highest frequency (67.3% vs 67.8%), with a significant increasing trend across the groups (p value for trend <0.001). The white matter lesions volume increased significantly with lower frequency of social contact (0.30% in the lowest frequency vs 0.26% in the highest frequency group, p value for trend <0.001). Lower frequency of social contact was associated with smaller volumes in the temporal lobe, occipital lobe, cingulum, hippocampus, and amygdala (all q value of FDR correction <0.05). The relationships appeared to be partly mediated by depressive symptoms, which accounted for 15% to 29% of the observed associations. DISCUSSION: Lower frequency of social contact was associated with decreased total and cognitive function-related regional brain volumes. In addition, depressive symptoms partially explained the association in community-dwelling older people without dementia in Japan.

  • Changes in the eicosapentaenoic acid to arachidonic acid ratio in serum over 10 years in a Japanese community: the Hisayama Study Reviewed

    Honda T, Chen S, Hata J, Shibata M, Furuta Y, Oishi E, Sakata S, Kitazono T, Ninomiya T.

    J Atheroscler Thromb   2023.6

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    DOI: 10.5551/jat.63727

  • Serum Mac-2 binding protein glycosylation isomer concentrations are associated with incidence of type 2 diabetes Reviewed International journal

    Higashioka M, Hirakawa Y, Hata J, Honda T, Sakata S, Shibata M, Kitazono T, Osawa H, Ninomiya T.

    J Clin Endocrinol Metab   2023.6

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    DOI: 10.1210/clinem/dgad011

  • Association between choroidal thickness and myopic maculopathy in a Japanese population: the Hisayama Study Reviewed International journal

    Emi Ueda, Miho Yasuda, Kohta Fujiwara, Sawako Hashimoto, Takanori Honda, Shun Nakamura, Jun Hata, Toshiharu Ninomiya, Koh-Hei Sonoda

    Ophthalmology Science   100350 - 100350   2023.6

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    DOI: 10.1016/j.xops.2023.100350

  • Association of white matter lesions and brain atrophy with the development of dementia in a community: the Hisayama Study Reviewed

    Nakazawa T, Ohara T, Hirabayashi N, Furuta Y, Hata J, Shibata M, Honda T, Kitazono T, Nakao T, Ninomiya T.

    Psychiatry Clin Neurosci   2023.6

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    DOI: 10.1111/pcn.13533

  • CKD, Brain Atrophy, and White Matter Lesion Volume: The Japan Prospective Studies Collaboration for Aging and Dementia. International journal

    Kenji Maki, Tomoyuki Ohara, Jun Hata, Mao Shibata, Naoki Hirabayashi, Takanori Honda, Satoko Sakata, Yoshihiko Furuta, Masato Akiyama, Keisuke Yamasaki, Yasuko Tatewaki, Yasuyuki Taki, Takanari Kitazono, Tatsuya Mikami, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya

    Kidney medicine   5 ( 3 )   100593 - 100593   2023.3

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    RATIONALE & OBJECTIVE: Chronic kidney disease, defined by albuminuria and/or reduced estimated glomerular filtration rate (eGFR), has been reported to be associated with brain atrophy and/or higher white matter lesion volume (WMLV), but there are few large-scale population-based studies assessing this issue. This study aimed to examine the associations between the urinary albumin-creatinine ratio (UACR) and eGFR levels and brain atrophy and WMLV in a large-scale community-dwelling older population of Japanese. STUDY DESIGN: Population-based cross-sectional study. SETTING & PARTICIPANTS: A total of 8,630 dementia-free community-dwelling Japanese aged greater than or equal to 65 years underwent brain magnetic resonance imaging scanning and screening examination of health status in 2016-2018. EXPOSURES: UACR and eGFR levels. OUTCOMES: The total brain volume (TBV)-to-intracranial volume (ICV) ratio (TBV/ICV), the regional brain volume-to-TBV ratio, and the WMLV-to-ICV ratio (WMLV/ICV). ANALYTICAL APPROACH: The associations of UACR and eGFR levels with the TBV/ICV, the regional brain volume-to-TBV ratio, and the WMLV/ICV were assessed by using an analysis of covariance. RESULTS: Higher UACR levels were significantly associated with lower TBV/ICV and higher geometric mean values of the WMLV/ICV (P for trend = 0.009 and <0.001, respectively). Lower eGFR levels were significantly associated with lower TBV/ICV, but not clearly associated with WMLV/ICV. In addition, higher UACR levels, but not lower eGFR, were significantly associated with lower temporal cortex volume-to-TBV ratio and lower hippocampal volume-to-TBV ratio. LIMITATIONS: Cross-sectional study, misclassification of UACR or eGFR levels, generalizability to other ethnicities and younger populations, and residual confounding factors. CONCLUSIONS: The present study demonstrated that higher UACR was associated with brain atrophy, especially in the temporal cortex and hippocampus, and with increased WMLV. These findings suggest that chronic kidney disease is involved in the progression of morphologic brain changes associated with cognitive impairment.

    DOI: 10.1016/j.xkme.2022.100593

  • Secular trends in the prevalence, incidence, and progression of diabetic retinopathy: the Hisayama Study Reviewed International journal

    Hashimoto S, Yasuda M, Fujiwara K, Ueda E, Nakamura S, Hirakawa Y, Higashioka M, Hata J, Ninomiya T, Sonoda KH.

    Graefes Arch Clin Exp Ophthalmol   2023.3

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    DOI: 10.1007/s00417-022-05839-8

  • Association of gait speed with regional brain volumes and risk of dementia in older Japanese: the Hisayama study Reviewed International journal

    Tajimi T, Furuta Y, Hirabayashi N, Honda T, Hata J, Ohara T, Shibata M, Nakao T, Kitazono T, Nakashima Y, Ninomiya T.

    Arch Gerontol Geriatr   2023.3

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    DOI: 10.1016/j.archger.2022.104883

  • Diminishing benefits of urban living for children and adolescents' growth and development Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Nature   2023.3

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    DOI: 10.1038/s41586-023-05772-8

  • CKD, brain atrophy, and white matter lesion volume: the Japan Prospective Studies Collaboration for Aging and Dementia Reviewed International journal

    Maki K, Ohara T, Hata J, Shibata M, Hirabayashi N, Honda T, Sakata S, Furuta Y, Akiyama M, Yamasaki K, Tatewaki Y, Taki Y, Kitazono T, Mikami T, Maeda T, Ono K, Mimura M, Nakashima K, Iga JI, Takebayashi M, Ninomiya T; Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) study group.

    Kidney Med   2022.12

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    DOI: 10.1016/j.xkme.2022.100593

  • Prevalence of glaucoma and its systemic risk factors in a general Japanese population: the Hisayama Study Reviewed International journal

    Fujiwara K, Yasuda M, Hata J, Nakano S, Hashimoto S, Ueda E, Nakamura S, Murakami Y, Nakamuro T, Iwase A, Araie M, Tawara A, Kubota T, Yoshitomi T, Ninomiya T, Sonoda KH.

    Transl Vis Sci Technol   2022.11

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    DOI: 10.1167/tvst.11.11.11

  • Mild-to-moderate kidney dysfunction and cardiovascular disease: observational and mendelian randomization analyses Reviewed International journal

    Gaziano L, Sun L, Arnold M, Bell S, Cho K, Kaptoge SK, Song RJ, Burgess S, Posner DC, Mosconi K, Robinson-Cohen C, Mason AM, Bolton TR, Tao R, Allara E, Schubert P, Chen L, Staley JR, Staplin N, Altay S, Amiano P, Arndt V, Ärnlöv J, Barr ELM, Björkelund C, Boer JMA, Brenner H, Casiglia E, Chiodini P, Cooper JA, Coresh J, Cushman M, Dankner R, Davidson KW, de Jongh RT, Donfrancesco C, Engström G, Freisling H, de la Cámara AG, Gudnason V, Hankey GJ, Hansson PO, Heath AK, Hoorn EJ, Imano H, Jassal SK, Kaaks R, Katzke V, Kauhanen J, Kiechl S, Koenig W, Kronmal RA, Kyrø C, Lawlor DA, Ljungberg B, MacDonald C, Masala G, Meisinger C, Melander O, Moreno Iribas C, Ninomiya T, Nitsch D, Nordestgaard BG, Onland-Moret C, Palmieri L, Petrova D, Garcia JRQ, Rosengren A, Sacerdote C, Sakurai M, Santiuste C, Schulze MB, Sieri S, Sundström J, Tikhonoff V, Tjønneland A, Tong T, Tumino R, Tzoulaki I, van der Schouw YT, Monique Verschuren WM, Völzke H, Wallace RB, Wannamethee SG, Weiderpass E, Willeit P, Woodward M, Yamagishi K, Zamora-Ros R, Akwo EA, Pyarajan S, Gagnon DR, Tsao PS, Muralidhar S, Edwards TL, Damrauer SM, Joseph J, Pennells L, Wilson PWF, Harrison S, et al.

    Circulation   2022.11

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    DOI: 10.1161/CIRCULATIONAHA.122.060700

  • Stroke genetics informs drug discovery and risk prediction across ancestries Reviewed International journal

    Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, He Y, Georgakis MK, Caro I, Krebs K, Liaw YC, Vaura FC, Lin K, Winsvold BS, Srinivasasainagendra V, Parodi L, Bae HJ, Chauhan G, Chong MR, Tomppo L, Akinyemi R, Roshchupkin GV, Habib N, Jee YH, Thomassen JQ, Abedi V, Cárcel-Márquez J, Nygaard M, Leonard HL, Yang C, Yonova-Doing E, Knol MJ, Lewis AJ, Judy RL, Ago T, Amouyel P, Armstrong ND, Bakker MK, Bartz TM, Bennett DA, Bis JC, Bordes C, Børte S, Cain A, Ridker PM, Cho K, Chen Z, Cruchaga C, Cole JW, de Jager PL, de Cid R, Endres M, Ferreira LE, Geerlings MI, Gasca NC, Gudnason V, Hata J, He J, Heath AK, Ho YL, Havulinna AS, Hopewell JC, Hyacinth HI, Inouye M, Jacob MA, Jeon CE, Jern C, Kamouchi M, Keene KL, Kitazono T, Kittner SJ, Konuma T, Kumar A, Lacaze P, Launer LJ, Lee KJ, Lepik K, Li J, Li L, Manichaikul A, Markus HS, Marston NA, Meitinger T, Mitchell BD, Montellano FA, Morisaki T, Mosley TH, Nalls MA, Nordestgaard BG, O'Donnell MJ, Okada Y, Onland-Moret NC, Ovbiagele B, Peters A, Psaty BM, Rich SS, et al.

    Nature   2022.11

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    DOI: 10.1038/s41586-022-05165-3

  • Day-to-day blood pressure variability and risk of incident chronic kidney disease in a general Japanese population Reviewed International journal

    Sasaki T, Sakata S, Oishi E, Furuta Y, Honda T, Hata J, Tsuboi N, Kitazono T, Yokoo T, Ninomiya T.

    J Am Heart Assoc   2022.10

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    DOI: 10.1161/JAHA.122.027173

  • Altruistic social activity, depressive symptoms, and brain regional gray matter volume: voxel-based morphometry analysis from 8,695 old adults Reviewed International journal

    Liu Y, Zhang Y, Thyreau B, Tatewaki Y, Matsudaira I, Takano Y, Hirabayashi N, Furuta Y, Hata J, Ninomiya T, Taki Y; Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) Study Group.

    J Gerontol A Biol Sci Med Sci   2022.9

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    DOI: 10.1093/gerona/glac093

  • Association of the prefrailty with global brain atrophy and white matter lesions among cognitively unimpaired older adults: the Nakajima study Reviewed International journal

    Noguchi-Shinohara M, Ono K, Yuki-Nozaki S, Iwasa K, Yokogawa M, Komai K, Thyreau B, Tatewaki Y, Taki Y, Shibata M, Ohara T, Hata J, Ninomiya T, Yamada M.

    Sci Rep   2022.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-022-16190-7

  • Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community Reviewed International journal

    Mihara A, Ohara T, Hata J, Chen S, Honda T, Tamrakar S, Isa A, Wang D, Shimizu K, Katakura Y, Yonemoto K, Nakao T, Kitazono T, Ninomiya T.

    Sci Rep   2022.7

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    DOI: 10.1038/s41598-022-16242-y

  • Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations Reviewed International journal

    Gerard Temprano‐Sagrera, Colleen M. Sitlani, William P. Bone, Miguel Martin‐Bornez, Benjamin F. Voight, Alanna C. Morrison, Scott M. Damrauer, Paul S. de Vries, Nicholas L. Smith, Maria Sabater‐Lleal, Abbas Dehghan, Adam S Heath, Alanna C Morrison, Alex P Reiner, Andrew Johnson, Anne Richmond, Annette Peters, Astrid van Hylckama Vlieg, Barbara McKnight, Bruce M Psaty, Caroline Hayward, Cavin Ward‐Caviness, Christopher O’Donnell, Daniel Chasman, David P Strachan, David A Tregouet, Dennis Mook‐Kanamori, Dipender Gill, Florian Thibord, Folkert W Asselbergs, Frank W.G. Leebeek, Frits R Rosendaal, Gail Davies, Georg Homuth, Gerard Temprano, Harry Campbell, Herman A Taylor, Jan Bressler, Jennifer E Huffman, Jerome I Rotter, Jie Yao, James F Wilson, Joshua C Bis, Julie M Hahn, Karl C Desch, Kerri L Wiggins, Laura M Raffield, Lawrence F Bielak, Lisa R Yanek, Marcus E Kleber, Maria Sabater‐Lleal, Martina Mueller, Maryam Kavousi, Massimo Mangino, Melissa Liu, Michael R Brown, Matthew P Conomos, Min‐A Jhun, Ming‐Huei Chen, Moniek P.M. de Maat, Nathan Pankratz, Nicholas L Smith, Patricia A Peyser, Paul Elliot, Paul S de Vries, Peng Wei, Philipp S Wild, Pierre E Morange, Pim van der Harst, Qiong Yang, Ngoc‐Quynh Le, Riccardo Marioni, Ruifang Li, Scott M Damrauer, Simon R Cox, Stella Trompet, Stephan B Felix, Uwe Völker, Weihong Tang, Wolfgang Koenig, J. Wouter Jukema, Xiuqing Guo, Sara Lindstrom, Lu Wang, Erin N Smith, William Gordon, Astrid van Hylckama Vlieg, Mariza de Andrade, Jennifer A Brody, Jack W Pattee, Jeffrey Haessler, Ben M Brumpton, Daniel I Chasman, Pierre Suchon, Ming‐Huei Chen, Constance Turman, Marine Germain, Kerri L Wiggins, James MacDonald, Sigrid K Braekkan, Sebastian M Armasu, Nathan Pankratz, Rabecca D Jackson, Jonas B Nielsen, Franco Giulianini, Marja K Puurunen, Manal Ibrahim, Susan R Heckbert, Theo K Bammler, Kelly A Frazer, Bryan M McCauley, Kent Taylor, James S Pankow, Alexander P Reiner, Maiken E Gabrielsen, Jean‐François Deleuze, Chris J O’Donnell, Jihye Kim, Barbara McKnight, Peter Kraft, John‐Bjarne Hansen, Frits R Rosendaal, John A Heit, Bruce M Psaty, Weihong Tang, Charles Kooperberg, Kristian Hveem, Paul M Ridker, Pierre‐Emmanuel Morange, Andrew D Johnson, Christopher Kabrhel, David‐Alexandre Trégouët, Nicholas L Smith, Rainer Malik, Ganesh Chauhan, Matthew Traylor, Muralidharan Sargurupremraj, Yukinori Okada, Aniket Mishra, Loes Rutten‐Jacobs, Anne‐Katrin Giese, Sander W van der Laan, Solveig Gretarsdottir, Christopher D Anderson, Michael Chong, Hieab HH Adams, Tetsuro Ago, Peter Almgren, Philippe Amouyel, Hakan Ay, Traci M Bartz, Oscar R Benavente, Steve Bevan, Giorgio B Boncoraglio, Robert D Brown, Adam S Butterworth, Caty Carrera, Cara L Carty, Daniel I Chasman, Wei‐Min Chen, John W Cole, Adolfo Correa, Ioana Cotlarciuc, Carlos Cruchaga, John Danesh, Paul IW de Bakker, Anita L DeStefano, Marcel den Hoed, Qing Duan, Stefan T Engelter, Guido J Falcone, Rebecca F Gottesman, Raji P Grewal, Vilmundur Gudnason, Stefan Gustafsson, Jeffrey Haessler, Tamara B Harris, Ahamad Hassan, Aki S Havulinna, Susan R Heckbert, Elizabeth G Holliday, George Howard, Fang‐Chi Hsu, Hyacinth I Hyacinth, M Arfan Ikram, Erik Ingelsson, Marguerite R Irvin, Xueqiu Jian, Jordi Jiménez‐Conde, Julie A Johnson, J Wouter Jukema, Masahiro Kanai, Keith L Keene, Brett M Kissela, Dawn O Kleindorfer, Charles Kooperberg, Michiaki Kubo, Leslie A Lange, Carl D Langefeld, Claudia Langenberg, Lenore J Launer, Jin‐Moo Lee, Robin Lemmens, Didier Leys, Cathryn M Lewis, Wei‐Yu Lin, Arne G Lindgren, Erik Lorentzen, Patrik K Magnusson, Jane Maguire, Ani Manichaikul, Patrick F McArdle, James F Meschia, Braxton D Mitchell, Thomas H Mosley, Michael A Nalls, Toshiharu Ninomiya, Martin J O’Donnell, Bruce M Psaty, Sara L Pulit, Kristiina Rannikmäe, Alexander P Reiner, Kathryn M Rexrode, Kenneth Rice, Stephen S Rich, Paul M Ridker, Natalia S Rost, Peter M Rothwell, Jerome I Rotter, Tatjana Rundek, Ralph L Sacco, Saori Sakaue, Michele M Sale, Veikko Salomaa, Bishwa R Sapkota, Reinhold Schmidt, Carsten O Schmidt, Ulf Schminke, Pankaj Sharma, Agnieszka Slowik, Cathie LM Sudlow, Christian Tanislav, Turgut Tatlisumak, Kent D Taylor, Vincent NS Thijs, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Steffen Tiedt, Stella Trompet, Christophe Tzourio, Cornelia M van Duijn, Matthew Walters, Nicholas J Wareham, Sylvia Wassertheil‐Smoller, James G Wilson, Kerri L Wiggins, Qiong Yang, Salim Yusuf, Najaf Amin, Hugo S Aparicio, Donna K Arnett, John Attia, Alexa S Beiser, Claudine Berr, Julie E Buring, Mariana Bustamante, Valeria Caso, Yu‐Ching Cheng, Seung Hoan Choi, Ayesha Chowhan, Natalia Cullell, Jean‐François Dartigues, Hossein Delavaran, Pilar Delgado, Marcus Dörr, Gunnar Engström, Ian Ford, Wander S Gurpreet, Anders Hamsten, Laura Heitsch, Atsushi Hozawa, Laura Ibanez, Andreea Ilinca, Martin Ingelsson, Motoki Iwasaki, Rebecca D Jackson, Katarina Jood, Pekka Jousilahti, Sara Kaffashian, Lalit Kalra, Masahiro Kamouchi, Takanari Kitazono, Olafur Kjartansson, Manja Kloss, Peter J Koudstaal, Jerzy Krupinski, Daniel L Labovitz, Cathy C Laurie, Christopher R Levi, Linxin Li, Lars Lind, Cecilia M Lindgren, Vasileios Lioutas, Yong Mei Liu, Oscar L Lopez, Hirata Makoto, Nicolas Martinez‐Majander, Koichi Matsuda, Naoko Minegishi, Joan Montaner, Andrew P Morris, Elena Muiño, Martina Müller‐Nurasyid, Bo Norrving, Soichi Ogishima, Eugenio A Parati, Leema Reddy Peddareddygari, Nancy L Pedersen, Joanna Pera, Markus Perola, Alessandro Pezzini, Silvana Pileggi, Raquel Rabionet, Iolanda Riba‐Llena, Marta Ribasés, Jose R Romero, Jaume Roquer, Anthony G Rudd, Antti‐Pekka Sarin, Ralhan Sarju, Chloe Sarnowski, Makoto Sasaki, Claudia L Satizabal, Mamoru Satoh, Naveed Sattar, Norie Sawada, Gerli Sibolt, Ásgeir Sigurdsson, Albert Smith, Kenji Sobue, Carolina Soriano‐Tárraga, Tara Stanne, O Colin Stine, David J Stott, Konstantin Strauch, Takako Takai, Hideo Tanaka, Kozo Tanno, Alexander Teumer, Liisa Tomppo, Nuria P Torres‐Aguila, Emmanuel Touze, Shoichiro Tsugane, Andre G Uitterlinden, Einar M Valdimarsson, Sven J van der Lee, Henry Völzke, Kenji Wakai, David Weir, Stephen R Williams, Charles DA Wolfe, Quenna Wong, Huichun Xu, Taiki Yamaji, Dharambir K Sanghera, Olle Melander, Christina Jern, Daniel Strbian, Israel Fernandez‐Cadenas, W T Longstreth, Arndt Rolfs, Jun Hata, Daniel Woo, Jonathan Rosand, Guillaume Pare, Jemma C Hopewell, Danish Saleheen, Kari Stefansson, Bradford B Worrall, Steven J Kittner, Sudha Seshadri, Myriam Fornage, Hugh S Markus, Joanna MM Howson, Yoichiro Kamatani, Stephanie Debette, Martin Dichgans

    Journal of Thrombosis and Haemostasis   20 ( 6 )   1331 - 1349   2022.6

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    DOI: 10.1111/jth.15698

  • Association between diabetes and gray matter atrophy patterns in a general older Japanese population: the Hisayama Study Reviewed International journal

    Hirabayashi N, Hata J, Furuta Y, Ohara T, Shibata M, Hirakawa Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Ninomiya T.

    Diabetes Care   2022.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/dc21-1911

  • Higher-resolution quantification of white matter hypointensities by large-scale transfer learning from 2D images on the JPSC-AD cohort Reviewed International journal

    Thyreau B, Tatewaki Y, Chen L, Takano Y, Hirabayashi N, Furuta Y, Hata J, Nakaji S, Maeda T, Noguchi-Shinohara M, Mimura M, Nakashima K, Mori T, Takebayashi M, Ninomiya T, Taki Y; Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) Study Group.

    Hum Brain Mapp   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/hbm.25899

  • Active commuting, commuting modes and the risk of diabetes: 14-year follow-up data from the Hisayama Study Reviewed International journal

    Honda T, Hirakawa Y, Hata J, Chen S, Shibata M, Sakata S, Furuta Y, Higashioka M, Oishi E, Kitazono T, Ninomiya T.

    J Diabetes Investig   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jdi.13844

  • Risks of mortality and airflow limitation in Japanese with preserved ratio impaired spirometry Reviewed International journal

    Washio Y, Sakata S, Fukuyama S, Honda T, Kan-O K, Shibata M, Hata J, Inoue H, Kitazono T, Matsumoto K, Ninomiya T.

    Am J Respir Crit Care Med   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1164/rccm.202110-2302OC

  • Yogurt product intake and reduction of tooth loss risk in a Japanese community Reviewed International journal

    Ma J, Furuta M, Uchida K, Takeshita T, Kageyama S, Asakawa M, Takeuchi K, Suma S, Sakata S, Hata J, Sohn W, Ninomiya T, Yamashita Y.

    J Clin Periodontol   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jcpe.13593

  • Association of inner retinal thickness with prevalent dementia and brain atrophy in a general older population: the Hisayama Study Reviewed International journal

    Ueda E, Hirabayashi N, Ohara T, Hata J, Honda T, Fujiwara K, Furuta Y, Shibata M, Hashimoto S, Nakamura S, Nakazawa T, Nakao T, Kitazono T, Ninomiya T, Sonoda KH.

    Ophthalmol Sci   2022.4

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    DOI: 10.1016/j.xops.2022.100157

  • Baseline periodontal status and modifiable risk factors are associated with tooth loss over a 10-year period: estimates of population attributable risk in a Japanese community Reviewed International journal

    Furuta M, Takeuchi K, Takeshita T, Shibata Y, Suma S, Kageyama S, Asakawa M, Shimazaki Y, Hata J, Ninomiya T, Yamashita Y.

    J Periodontol   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/JPER.21-0191

  • Association of daily sleep duration with the incident dementia by serum soluble TREM2 in a community Reviewed International journal

    Ohara T, Hata J, Tanaka M, Honda T, Yamakage H, Inoue T, Hirakawa Y, Kusakabe T, Shibata M, Kitazono T, Nakao T, Satoh-Asahara N, Ninomiya T.

    J Am Geriatr Soc   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgs.17634

  • Development and validation of a risk prediction model for atherosclerotic cardiovascular disease in Japanese adults: the Hisayama Study Reviewed

    Honda T, Chen S, Hata J, Yoshida D, Hirakawa Y, Furuta Y, Shibata M, Sakata S, Kitazono T, Ninomiya T.

    J Atheroscler Thromb   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5551/jat.61960

  • Long-term association of vegetable and fruit intake with risk of dementia in Japanese older adults: the Hisayama Study Reviewed International journal

    Kimura Y, Yoshida D, Ohara T, Hata J, Honda T, Hirakawa Y, Shibata M, Oishi E, Sakata S, Furuta Y, Chen S, Uchida K, Nakao T, Kitazono T, Ninomiya T.

    BMC Geriatr   2022.3

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    DOI: 10.1186/s12877-022-02939-2

  • Association between chronic low back pain and regional brain atrophy in a Japanese older population: the Hisayama Study Reviewed International journal

    Asada M, Shibata M, Hirabayashi N, Ohara T, Furuta Y, Nakazawa T, Honda T, Hata J, Hosoi M, Sudo N, Yamaura K, Ninomiya T.

    Pain   2022.3

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    DOI: 10.1097/j.pain.0000000000002612

  • Multiple-region grey matter atrophy as a predictor for the development of dementia in a community: the Hisayama Study Reviewed International journal

    Nakazawa T, Ohara T, Hirabayashi N, Furuta Y, Hata J, Shibata M, Honda T, Kitazono T, Nakao T, Ninomiya T.

    J Neurol Neurosurg Psychiatry   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/jnnp-2021-326611

  • Changes in body weight and concurrent changes in cardiovascular risk profiles in community residents in Japan: the Hisayama Study Reviewed

    Honda T, Ishida Y, Oda M, Noguchi K, Chen S, Sakata S, Oishi E, Furuta Y, Yoshida D, Hirakawa Y, Hata J, Kitazono T, Ninomiya T.

    J Atheroscler Thromb   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5551/jat.59394

  • Long-term trends in the 5-year risk of recurrent stroke over a half century in a Japanese community: the Hisayama Study Reviewed

    Nakanishi Y, Furuta Y, Hata J, Yubi T, Oishi E, Sakata S, Hirakawa Y, Wakisaka Y, Ago T, Kitazono T, Ninomiya T.

    J Atheroscler Thromb   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5551/jat.63344

  • Day-by-day blood pressure variability in the subacute stage of ischemic stroke and long-term recurrence Reviewed International journal

    Fukuda K, Matsuo R, Kamouchi M, Kiyuna F, Sato N, Nakamura K, Hata J, Wakisaka Y, Ago T, Imaizumi T, Kai H, Kitazono T; FSR Investigators.

    Stroke   2022.1

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    DOI: 10.1161/STROKEAHA.120.033751

  • A comparative study of site-specific distribution of aging-related tau astrogliopathy and its risk factors between Alzheimer disease and cognitive healthy brains: the Hisayama Study Reviewed International journal

    Yagita K, Honda H, Ohara T, Hamasaki H, Koyama S, Noguchi H, Mihara A, Nakazawa T, Hata J, Ninomiya T, Iwaki T.

    J Neuropathol Exp Neurol   2022.1

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    DOI: 10.1093/jnen/nlab126

  • Diabetes mellitus, elevated hemoglobin A1c, and glycated albumin are associated with the presence of all-cause dementia and Alzheimer's disease: the JPSC-AD study Reviewed International journal

    Noguchi-Shinohara M, Yuki-Nozaki S, Abe C, Mori A, Horimoto M, Yokogawa M, Ishida N, Suga Y, Ishizaki J, Ishimiya M, Nakamura H, Komai K, Nakamura H, Shibata M, Ohara T, Hata J, Ninomiya T, Yamada M; Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) Study Group.

    J Alzheimers Dis   2022.1

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    DOI: 10.3233/JAD-215153

  • Serum uric acid levels and nephrosclerosis in a population-based autopsy study: the Hisayama Study Reviewed International journal

    Maki K, Hata J, Sakata S, Oishi E, Furuta Y, Nakano T, Oda Y, Kitazono T, Ninomiya T.

    Am J Nephrol   2022.1

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    DOI: 10.1159/000521426

  • Midlife and late-life diabetes and sarcopenia in a general older Japanese population: the Hisayama Study Reviewed International journal

    Nakamura K, Yoshida D, Honda T, Hata J, Shibata M, Hirakawa Y, Furuta Y, Kishimoto H, Ohara T, Chen S, Kitazono T, Nakashima Y, Ninomiya T.

    J Diabetes Investig   2021.10

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    DOI: 10.1111/jdi.13550

  • Emotional loneliness is associated with a risk of dementia in a general Japanese older population: the Hisayama Study Reviewed International journal

    Shibata M, Ohara T, Hosoi M, Hata J, Yoshida D, Hirabayashi N, Morisaki Y, Nakazawa T, Mihara A, Nagata T, Oishi E, Anno K, Sudo N, Ninomiya T.

    J Gerontol B Psychol Sci Soc Sci   2021.10

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    DOI: 10.1093/geronb/gbaa196

  • Development of a risk prediction model for incident hypertension in Japanese individuals: the Hisayama Study Reviewed

    Oishi E, Hata J, Honda T, Sakata S, Chen S, Hirakawa Y, Yoshida D, Shibata M, Ohara T, Furuta Y, Kitazono T, Ninomiya T.

    Hypertens Res   2021.9

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    DOI: 10.1038/s41440-021-00673-7

  • Pathologic diabetic nephropathy in autopsied diabetic cases with normoalbuminuria from a Japanese community-based study Reviewed International journal

    Sasaki T, Nakagawa K, Hata J, Hirakawa Y, Shibata M, Nakano T, Tsuboi N, Oda Y, Kitazono T, Yokoo T, Ninomiya T.

    Kidney Int Rep   2021.9

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    DOI: 10.1016/j.ekir.2021.09.007

  • Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Lancet   2021.9

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    DOI: 10.1016/S0140-6736(21)01330-1

  • Serum NT-proBNP levels and histopathological myocardial fibrosis in autopsied cases from a Japanese community: the Hisayama Study Reviewed International journal

    Sasaki T, Izumaru K, Hata J, Sakata S, Oishi E, Nagata T, Tsuboi N, Oda Y, Kitazono T, Yokoo T, Ninomiya T.

    J Cardiol   2021.9

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    DOI: 10.1016/j.jjcc.2021.03.014

  • β-cell function and clinical outcome in nondiabetic patients with acute ischemic stroke Reviewed International journal

    Kiyohara T, Matsuo R, Hata J, Nakamura K, Wakisaka Y, Kamouchi M, Kitazono T, Ago T; FSR Investigators.

    Stroke   2021.8

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    DOI: 10.1161/STROKEAHA.120.031392

  • 10-year trend of tooth loss and associated factors in a Japanese population-based longitudinal study. Reviewed International journal

    Michiko Furuta, Kenji Takeuchi, Toru Takeshita, Yukie Shibata, Shino Suma, Shinya Kageyama, Mikari Asakawa, Jun Hata, Daigo Yoshida, Yoshihiro Shimazaki, Toshiharu Ninomiya, Yoshihisa Yamashita

    BMJ open   11 ( 8 )   e048114   2021.8

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    OBJECTIVES: We examined the trend in the number of missing teeth in a Japanese community over a 10-year period and the potential associated explanatory factors. DESIGN: Prospective cohort study. SETTING: A population-based study conducted in 2007, 2012 and 2017 in Japan (Hisayama Study). PARTICIPANTS: Residents of a Japanese community aged 40-79 years undergoing dental examination in 2007 (n=2665), 2012 (n=2325) and 2017 (n=2285). OUTCOME MEASURES: The number of missing teeth, periodontal condition, dental caries experience, dental plaque index and oral health behaviours were evaluated each year. The longitudinal analysis of variation in these factors were assessed using mixed models. RESULTS: The age-adjusted and sex-adjusted mean number of missing teeth decreased with time (6.80 in 2007, 6.01 in 2012 and 4.99 in 2017). The mean clinical attachment level (CAL), prevalence of periodontitis and dental plaque index decreased over the study period, while dental caries experience slightly increased. The level of oral health behaviour increased over time. Poisson mixed models showed that changes in mean CAL and dental caries experience were positively associated with the change in the number of missing teeth over time. Linear mixed models showed that changes in dental plaque index and no regular dental visit were positively associated with changes in mean CAL. CONCLUSIONS: These findings suggest that a decreasing trend regarding the number of missing teeth in Japan might be associated with improvements in the periodontal condition due to changes in oral hygiene level and oral health behaviour.

    DOI: 10.1136/bmjopen-2020-048114

  • Comparison of the contributions of impaired beta cell function and insulin resistance to the development of type 2 diabetes in a Japanese community: the Hisayama Study Reviewed International journal

    Yoshinari M, Hirakawa Y, Hata J, Higashioka M, Honda T, Yoshida D, Mukai N, Nakamura U, Kitazono T, Ninomiya T.

    Diabetologia   2021.8

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    DOI: 10.1007/s00125-021-05459-7

  • Serum high-sensitivity C-reactive protein levels and the development of atrial fibrillation in a general Japanese population: the Hisayama Study Reviewed

    Yoshikawa T, Hata J, Sakata S, Nagata T, Hirakawa Y, Hirooka Y, Tsutsui H, Kitazono T, Ninomiya T.

    Circ J   2021.7

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    DOI: 10.1253/circj.CJ-20-0751

  • Development of a dementia prediction model for primary care: the Hisayama Study Reviewed International journal

    Honda T, Ohara T, Yoshida D, Shibata M, Ishida Y, Furuta Y, Oishi E, Hirakawa Y, Sakata S, Hata J, Nakao T, Ninomiya T.

    Alzheimers Dement (Amst)   2021.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/dad2.12221

  • Current status of the certification of long-term care insurance among individuals with dementia in a Japanese community: the Hisayama Study Reviewed International journal

    Ohara T, Yoshida D, Hata J, Shibata M, Honda T, Furuta Y, Hirabayashi N, Kitazono T, Nakao T, Ninomiya T.

    Psychiatry Clin Neurosci   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/pcn.13204

  • Airflow limitation and tongue microbiota in community-dwelling elderly individuals Reviewed International journal

    Takeshita T, Matsumoto K, Furuta M, Fukuyama S, Takeuchi K, Ogata H, Asakawa M, Kageyama S, Hata J, Ninomiya T, Inoue H, Yamashita Y.

    ERJ Open Res   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1183/23120541.00616-2020

  • Prevalence and mortality of sarcopenia in a community-dwelling older Japanese population: the Hisayama Study Reviewed

    Nakamura K, Yoshida D, Honda T, Hata J, Shibata M, Hirakawa Y, Furuta Y, Kishimoto H, Ohara T, Kitazono T, Nakashima Y, Ninomiya T.

    J Epidemiol   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2188/jea.JE20190289

  • Dietary fiber intake and risk of type 2 diabetes in a general Japanese population: the Hisayama Study Reviewed International journal

    Kimura Y, Yoshida D, Hirakawa Y, Hata J, Honda T, Shibata M, Sakata S, Uchida K, Kitazono T, Ninomiya T.

    J Diabetes Investig   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jdi.13377

  • Urinary N-terminal pro-B-type natriuretic peptide as a biomarker for cardiovascular events in a general Japanese population: the Hisayama Study Reviewed

    Yamasaki K, Hata J, Ide T, Nagata T, Sakata S, Yoshida D, Honda T, Hirakawa Y, Nakano T, Kitazono T, Tsutsui H, Ninomiya T.

    Environ Health Prev Med   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12199-021-00970-0

  • Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Elife   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.7554/eLife.60060

  • Risk prediction for new-onset atrial fibrillation using the Minnesota code electrocardiography classification system Reviewed International journal

    Igarashi Y, Nochioka K, Sakata Y, Tamai T, Ohkouchi S, Irokawa T, Ogawa H, Hayashi H, Fujihashi T, Yamanaka S, Shiroto T, Miyata S, Hata J, Yamada S, Ninomiya T, Yasuda S, Kurosawa H, Shimokawa H.

    Int J Cardiol Heart Vasc   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijcha.2021.100762

  • High serum folate concentrations are associated with decreased risk of mortality among Japanese adults Reviewed International journal

    Chen S, Honda T, Hata J, Sakata S, Furuta Y, Yoshida D, Shibata M, Ohara T, Hirakawa Y, Oishi E, Kitazono T, Ninomiya T.

    J Nutr   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jn/nxaa382

  • The association of small dense low-density lipoprotein cholesterol and coronary heart disease in subjects at high cardiovascular risk Reviewed

    Higashioka M, Sakata S, Honda T, Hata J, Shibata M, Yoshida D, Goto K, Kitazono T, Osawa H, Ninomiya T.

    J Atheroscler Thromb   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5551/jat.55350

  • N-terminal pro-B-type natriuretic peptide and incident CKD Reviewed International journal

    Sasaki T, Oishi E, Nagata T, Sakata S, Chen S, Furuta Y, Honda T, Yoshida D, Hata J, Tsuboi N, Kitazono T, Yokoo T, Ninomiya T.

    Kidney Int Rep   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ekir.2021.01.006

  • Serum N-terminal pro-B-type natriuretic peptide as a predictor for future development of atrial fibrillation in a general population: the Hisayama Study Reviewed International journal

    Nagata T, Hata J, Sakata S, Oishi E, Honda T, Furuta Y, Ohara T, Yoshida D, Hirakawa Y, Shibata M, Ide T, Kitazono T, Tsutsui H, Ninomiya T.

    Int J Cardiol   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ijcard.2020.06.018

  • Recent status of self-measured home blood pressure in the Japanese general population: a modern database on self-measured home blood pressure (MDAS) Reviewed

    Asayama K, Tabara Y, Oishi E, Sakata S, Hisamatsu T, Godai K, Kabayama M, Tatsumi Y, Hata J, Kikuya M, Kamide K, Miura K, Ninomiya T, Ohkubo T.

    Hypertens Res   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41440-020-0530-1

  • Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Lancet   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0140-6736(20)31859-6

  • Association between serum glycated albumin and risk of cardiovascular disease in a Japanese community: the Hisayama Study Reviewed International journal

    Mihara A, Ohara T, Hata J, Honda T, Chen S, Sakata S, Oishi E, Hirakawa Y, Nakao T, Kitazono T, Ninomiya T.

    Atherosclerosis   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.atherosclerosis.2020.08.016

  • Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) Reviewed

    Ninomiya T, Nakaji S, Maeda T, Yamada M, Mimura M, Nakashima K, Mori T, Takebayashi M, Ohara T, Hata J, Kokubo Y, Uchida K, Taki Y, Kumagai S, Yonemoto K, Yoshida H, Muto K, Momozawa Y, Akiyama M, Kubo M, Ikeda M, Kanba S, Kiyohara Y; JPSC-AD Study Group.

    Environ Health Prev Med   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12199-020-00903-3

  • Influence of the accumulation of unhealthy eating habits on obesity in a general Japanese population: the Hisayama Study Reviewed International journal

    Ishida Y, Yoshida D, Honda T, Hirakawa Y, Shibata M, Sakata S, Furuta Y, Oishi E, Hata J, Kitazono T, Ninomiya T.

    Nutrients   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/nu12103160

  • Association of glucose tolerance status with pancreatic β- and α-cell mass in community-based autopsy samples of Japanese individuals: the Hisayama Study Reviewed International journal

    Inaishi J, Saisho Y, Hirakawa Y, Yoshida D, Hata J, Mukai N, Watanabe Y, Oda Y, Itoh H, Ninomiya T.

    J Diabetes Investig   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jdi.13232

  • Five-year incidence of myopic maculopathy in a general Japanese population: the Hisayama Study Reviewed International journal

    Ueda E, Yasuda M, Fujiwara K, Hashimoto S, Ohno-Matsui K, Hata J, Ishibashi T, Ninomiya T, Sonoda KH.

    JAMA Ophthalmol   2020.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1001/jamaophthalmol.2020.2211

  • Lifetime cumulative incidence of dementia in a community-dwelling elderly population in Japan Reviewed International journal

    Yoshida D, Ohara T, Hata J, Shibata M, Hirakawa Y, Honda T, Furuta Y, Oishi E, Sakata S, Kanba S, Kitazono T, Ninomiya T.

    Neurology   2020.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/WNL.0000000000009917

  • Elevated serum glycated albumin and glycated albumin : hemoglobin A1c ratio were associated with hippocampal atrophy in a general elderly population of Japanese: the Hisayama Study Reviewed International journal

    Ohara T, Furuta Y, Hirabayashi N, Hata J, Hirakawa Y, Honda T, Yoshida D, Shibata M, Kitazono T, Ninomiya T.

    J Diabetes Investig   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jdi.13220

  • 30-minute postload plasma glucose levels during an oral glucose tolerance test predict the risk of future type 2 diabetes: the Hisayama Study Reviewed International journal

    Hirakawa Y, Hata J, Yoshinari M, Higashioka M, Yoshida D, Shibata M, Honda T, Sakata S, Kato H, Teramoto T, Maki H, Nishimoto S, Kitazono T, Ninomiya T.

    BMJ Open Diabetes Res Care   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/bmjdrc-2019-001156

  • Small dense low-density lipoprotein cholesterol and the risk of coronary heart disease in a Japanese community Reviewed

    Higashioka M, Sakata S, Honda T, Hata J, Yoshida D, Hirakawa Y, Shibata M, Goto K, Kitazono T, Osawa H, Ninomiya T.

    J Atheroscler Thromb   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5551/jat.51961

  • Serum uric acid levels and cardiovascular mortality in a general Japanese population: the Hisayama Study Reviewed

    Sakata S, Hata J, Honda T, Hirakawa Y, Oishi E, Shibata M, Yoshida D, Goto K, Kitazono T, Ninomiya T.

    Hypertens Res   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41440-019-0390-8

  • Repositioning of the global epicentre of non-optimal cholesterol Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Nature   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41586-020-2338-1

  • Serum homocysteine and risk of dementia in Japan Reviewed International journal

    Chen S, Honda T, Ohara T, Hata J, Hirakawa Y, Yoshida D, Shibata M, Sakata S, Oishi E, Furuta Y, Kitazono T, Ninomiya T.

    J Neurol Neurosurg Psychiatry   2020.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/jnnp-2019-322366

  • Association of albuminuria with white matter hyperintensities volume on brain magnetic resonance imaging in elderly Japanese: the Hisayama Study Reviewed

    Yamasaki K, Hata J, Furuta Y, Hirabayashi N, Ohara T, Yoshida D, Hirakawa Y, Nakano T, Kitazono T, Ninomiya T.

    Circ J   2020.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-19-1069

  • Ratios of serum eicosapentaenoic acid to arachidonic acid and docosahexaenoic acid to arachidonic acid were inversely associated with serum resistin levels: the Hisayama Study Reviewed International journal

    Higashioka M, Hirakawa Y, Kawamura R, Honda T, Hata J, Yoshida D, Takata Y, Kitazono T, Osawa H, Ninomiya T.

    J Diabetes Investig   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jdi.13129

  • Disrupted tongue microbiota and detection of nonindigenous bacteria on the day of allogeneic hematopoietic stem cell transplantation Reviewed International journal

    Oku S, Takeshita T, Futatsuki T, Kageyama S, Asakawa M, Mori Y, Miyamoto T, Hata J, Ninomiya T, Kashiwazaki H, Yamashita Y.

    PLoS Pathog   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.ppat.1008348

  • Genome-wide polygenic score and the risk of ischemic stroke in a prospective cohort: the Hisayama Study Reviewed International journal

    Hachiya T, Hata J, Hirakawa Y, Yoshida D, Furuta Y, Kitazono T, Shimizu A, Ninomiya T.

    Stroke   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.119.027520

  • National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Int J Epidemiol   2020.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ije/dyz099

  • Anticoagulation and risk of stroke recurrence in patients with embolic stroke of undetermined source having no potential source of embolism Reviewed International journal

    Sato N, Matsuo R, Kiyuna F, Nakamura K, Hata J, Wakisaka Y, Ago T, Kamouchi M, Kitazono T; the Fukuoka Stroke Registry Investigators.

    Cerebrovasc Dis   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000510773

  • Decline in handgrip strength from midlife to late-life is associated with dementia in a Japanese community: the Hisayama Study Reviewed

    Hatabe Y, Shibata M, Ohara T, Oishi E, Yoshida D, Honda T, Hata J, Kanba S, Kitazono T, Ninomiya T.

    J Epidemiol   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2188/jea.JE20180137

  • Long-term regular exercise and intraocular pressure: the Hisayama Study Reviewed International journal

    Fujiwara K, Yasuda M, Hata J, Yoshida D, Kishimoto H, Hashimoto S, Yoshitomi T, Ninomiya T, Sonoda KH.

    Graefes Arch Clin Exp Ophthalmol   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00417-019-04441-9

  • Serum elaidic acid concentration and risk of dementia: the Hisayama Study Reviewed International journal

    Honda T, Ohara T, Shinohara M, Hata J, Toh R, Yoshida D, Shibata M, Ishida T, Hirakawa Y, Irino Y, Sakata S, Uchida K, Kitazono T, Kanba S, Hirata KI, Ninomiya T.

    Neurology   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/WNL.0000000000008464

  • Serum lipopolysaccharide-binding protein levels and the incidence of cardiovascular disease in a general Japanese population: the Hisayama Study Reviewed International journal

    Asada M, Oishi E, Sakata S, Hata J, Yoshida D, Honda T, Furuta Y, Shibata M, Suzuki K, Watanabe H, Murayama N, Kitazono T, Yamaura K, Ninomiya T.

    J Am Heart Assoc   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/JAHA.119.013628

  • Association between axial length and myopic maculopathy: the Hisayama Study Reviewed International journal

    Hashimoto S, Yasuda M, Fujiwara K, Ueda E, Hata J, Hirakawa Y, Ninomiya T, Sonoda KH.

    Ophthalmol Retina   2019.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.oret.2019.04.023

  • Glucose tolerance levels and circumpapillary retinal nerve fiber layer thickness in a general Japanese population: the Hisayama Study Reviewed International journal

    Fujiwara K, Yasuda M, Hata J, Hirakawa Y, Hashimoto S, Ueda E, Iwase A, Araie M, Yoshitomi T, Ninomiya T, Sonoda KH.

    Am J Ophthalmol   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ajo.2019.03.031

  • NT-proBNP and risk of dementia in a general Japanese elderly population: the Hisayama Study Reviewed International journal

    Nagata T, Ohara T, Hata J, Sakata S, Furuta Y, Yoshida D, Honda T, Hirakawa Y, Ide T, Kanba S, Kitazono T, Tsutsui H, Ninomiya T.

    J Am Heart Assoc   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/JAHA.118.011652

  • Reduced estimated gfr and cardiac remodeling: a population-based autopsy study Reviewed International journal

    Izumaru K, Hata J, Nakano T, Nakashima Y, Nagata M, Fukuhara M, Oda Y, Kitazono T, Ninomiya T.

    Am J Kidney Dis   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1053/j.ajkd.2019.02.013

  • Association between genetic risk and development of type 2 diabetes in a general Japanese population: the Hisayama Study Reviewed International journal

    Inaishi J, Hirakawa Y, Horikoshi M, Akiyama M, Higashioka M, Yoshinari M, Hata J, Mukai N, Kamatani Y, Momozawa Y, Kubo M, Ninomiya T.

    J Clin Endocrinol Metab   2019.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/jc.2018-01782

  • Serum ethylamine levels as an indicator of l-theanine consumption and the risk of type 2 diabetes in a general Japanese population: the Hisayama Study Reviewed International journal

    Ninomiya T, Kanzaki N, Hirakawa Y, Yoshinari M, Higashioka M, Honda T, Shibata M, Sakata S, Yoshida D, Teramoto T, Takemoto S, Nishimoto S, Hata J, Kitazono T.

    Diabetes Care   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/dc18-2655

  • Trends in the prevalence of myopia and myopic maculopathy in a Japanese population: the Hisayama Study Reviewed International journal

    Ueda E, Yasuda M, Fujiwara K, Hashimoto S, Ohno-Matsui K, Hata J, Ishibashi T, Ninomiya T, Sonoda KH.

    Invest Ophthalmol Vis Sci   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1167/iovs.19-26580

  • Dairy consumption and risk of functional disability in an elderly Japanese population: the Hisayama Study Reviewed International journal

    Yoshida D, Ohara T, Hata J, Shibata M, Hirakawa Y, Honda T, Uchida K, Takasugi S, Kitazono T, Kiyohara Y, Ninomiya T.

    Am J Clin Nutr   2019.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ajcn/nqz040

  • Objectively measured sedentary time and diabetes mellitus in a general Japanese population: the Hisayama Study Reviewed International journal

    Honda T, Kishimoto H, Mukai N, Hata J, Yoshida D, Hirakawa Y, Shibata M, Ohara T, Kumagai S, Ninomiya T.

    J Diabetes Investig   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jdi.12968

  • Periodontitis is associated with chronic obstructive pulmonary disease Reviewed International journal

    Takeuchi K, Matsumoto K, Furuta M, Fukuyama S, Takeshita T, Ogata H, Suma S, Shibata Y, Shimazaki Y, Hata J, Ninomiya T, Nakanishi Y, Inoue H, Yamashita Y.

    J Dent Res   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1177/0022034519833630

  • Rising rural body-mass index is the main driver of the global obesity epidemic in adults Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Nature   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41586-019-1171-x

  • Poor glycemic control and posterior circulation ischemic stroke Reviewed International journal

    Kuroda J, Matsuo R, Yamaguchi Y, Sato N, Kamouchi M, Hata J, Wakisaka Y, Ago T, Kitazono T; Fukuoka Stroke Registry Investigators.

    Neurol Clin Pract   2019.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/CPJ.0000000000000608

  • Trends in the prevalence of airflow limitation in a general Japanese population: two serial cross-sectional surveys from the Hisayama Study Reviewed International journal

    Ogata H, Hirakawa Y, Matsumoto K, Hata J, Yoshida D, Fukuyama S, Inoue H, Kitazono T, Ninomiya T, Nakanishi Y.

    BMJ Open   2019.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/bmjopen-2018-023673

  • Longitudinal changes of physical activity and sedentary time in the middle-aged and older Japanese population: the Hisayama Study Reviewed International journal

    Yonemoto K, Honda T, Kishimoto H, Yoshida D, Hata J, Mukai N, Shibata M, Hirakawa Y, Ninomiya T, Kumagai S.

    J Phys Act Health   2019.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1123/jpah.2017-0701

  • Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study Reviewed International journal

    Larsson SC, Traylor M, Burgess S, Boncoraglio GB, Jern C, Michaëlsson K, Markus HS; MEGASTROKE project of the International Stroke Genetics Consortium.

    Neurology   2019.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/WNL.0000000000007001

  • Serum soluble triggering receptor expressed on myeloid cells 2 as a biomarker for incident dementia: the Hisayama Study Reviewed International journal

    Ohara T, Hata J, Tanaka M, Honda T, Yamakage H, Yoshida D, Inoue T, Hirakawa Y, Kusakabe T, Shibata M, Teraoka T, Kitazono T, Kanba S, Satoh-Asahara N, Ninomiya T.

    Ann Neurol   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ana.25385

  • Prevalence of adult epilepsy in a general Japanese population: the Hisayama Study Reviewed International journal

    Tanaka A, Hata J, Akamatsu N, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Ohara T, Mizuno T, Tsuji S, Kitazono T, Ninomiya T.

    Epilepsia Open   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/epi4.12295

  • Moyamoya disease susceptibility variant RNF213 p.R4810K increases the risk of ischemic stroke attributable to large-artery atherosclerosis Reviewed International journal

    Okazaki S, Morimoto T, Kamatani Y, Kamimura T, Kobayashi H, Harada K, Tomita T, Higashiyama A, Takahashi JC, Nakagawara J, Koga M, Toyoda K, Washida K, Saito S, Takahashi A, Hirata M, Matsuda K, Mochizuki H, Chong M, Paré G, O'Donnell M, Ago T, Hata J, Ninomiya T, Dichgans M, Debette S, Kubo M, Koizumi A, Ihara M.

    Circulation   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/CIRCULATIONAHA.118.038439

  • A potential novel pathological implication of serum soluble triggering receptor expressed on myeloid cell 2 in insulin resistance in a general Japanese population: the Hisayama Study Reviewed International journal

    Tanaka M, Honda T, Yamakage H, Hata J, Yoshida D, Hirakawa Y, Shibata M, Inoue T, Kusakabe T, Satoh-Asahara N, Ninomiya T.

    Diabetes Res Clin Pract   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.diabres.2018.10.007

  • GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes Reviewed International journal

    Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu L, Scholz M, Sargurupremraj M, Pitkänen N, Franzén O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O'Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, Völzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang J, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney LALM, Lind L, Raffield LM, Launer LJ, Holdt LM, Dörr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Melander O, Raitakari O, Franco OH, Rueda-Ochoa OL, Roussos P, Whincup PH, Amouyel P, Giral P, et al.

    Nat Commun   2018.12

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    DOI: 10.1038/s41467-018-07340-5

  • Development and validation of modified risk prediction models for cardiovascular disease and its subtypes: the Hisayama Study Reviewed International journal

    Honda T, Yoshida D, Hata J, Hirakawa Y, Ishida Y, Shibata M, Sakata S, Kitazono T, Ninomiya T.

    Atherosclerosis   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.atherosclerosis.2018.10.014

  • Comparison of the periodontal condition in Korean and Japanese adults: a cross-sectional study Reviewed International journal

    Furuta M, Takeuchi K, Shimazaki Y, Takeshita T, Shibata Y, Hata J, Yoshida D, Park DY, Ninomiya T, Yamashita Y

    BMJ Open   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    Comparison of the periodontal condition in Korean and Japanese adults: a cross-sectional study

    DOI: 10.1136/bmjopen-2018-024332

  • Trends in the prevalence of type 2 diabetes and prediabetes in a Japanese community, 1988-2012: the Hisayama Study Reviewed International journal

    Mukai N, Hata J, Hirakawa Y, Ohara T, Yoshida D, Nakamura U, Kitazono T, Ninomiya T.

    Diabetol Int   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s13340-018-0380-0

  • Association between daily sleep duration and risk of dementia and mortality in a Japanese community Reviewed International journal

    Ohara T, Honda T, Hata J, Yoshida D, Mukai N, Hirakawa Y, Shibata M, Kishimoto H, Kitazono T, Kanba S, Ninomiya T.

    J Am Geriatr Soc   2018.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgs.15446

  • Association between the ratio of serum arachidonic acid to eicosapentaenoic acid and the presence of depressive symptoms in a general Japanese population: the Hisayama Study Reviewed International journal

    Shibata M, Ohara T, Yoshida D, Hata J, Mukai N, Kawano H, Kanba S, Kitazono T, Ninomiya T.

    J Affect Disord   2018.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jad.2018.05.004

  • Association of embolic sources with cause-specific functional outcomes among adults with cryptogenic stroke Reviewed International journal

    Kiyuna F, Sato N, Matsuo R, Kamouchi M, Hata J, Wakisaka Y, Kuroda J, Ago T, Kitazono T; Fukuoka Stroke Registry Investigators.

    JAMA Netw Open   2018.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1001/jamanetworkopen.2018.2953

  • Periodontal status and lung function decline in the community: the Hisayama Study Reviewed International journal

    Takeuchi K, Matsumoto K, Furuta M, Fukuyama S, Takeshita T, Ogata H, Suma S, Shibata Y, Shimazaki Y, Hata J, Ninomiya T, Nakanishi Y, Inoue H, Yamashita Y.

    Sci Rep   2018.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-31610-3

  • Tongue microbiota and oral health status in community-dwelling elderly adults Reviewed International journal

    Asakawa M, Takeshita T, Furuta M, Kageyama S, Takeuchi K, Hata J, Ninomiya T, Yamashita Y.

    mSphere   2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/mSphere.00332-18

  • Secular trends in the incidence, risk factors, and prognosis of transient ischemic attack in Japan: the Hisayama Study Reviewed International journal

    Furuta Y, Hata J, Mukai N, Hirakawa Y, Ago T, Kitazono T, Kiyohara Y, Ninomiya T.

    Atherosclerosis   2018.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.atherosclerosis.2018.04.010

  • Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community Reviewed International journal

    Yubi T, Hata J, Ohara T, Mukai N, Hirakawa Y, Yoshida D, Gotoh S, Hirabayashi N, Furuta Y, Ago T, Kitazono T, Kiyohara Y, Ninomiya T.

    Neurol Clin Pract   2018.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/CPJ.0000000000000464

  • Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Int J Epidemiol   2018.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ije/dyy016

  • Development and validation of a risk assessment tool for gastric cancer in a general Japanese population Reviewed International journal

    Iida M, Ikeda F, Hata J, Hirakawa Y, Ohara T, Mukai N, Yoshida D, Yonemoto K, Esaki M, Kitazono T, Kiyohara Y, Ninomiya T.

    Gastric Cancer   2018.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10120-017-0768-8

  • Patterns and levels of sedentary behavior and physical activity in a general Japanese population: the Hisayama Study Reviewed

    Chen T, Kishimoto H, Honda T, Hata J, Yoshida D, Mukai N, Shibata M, Ninomiya T, Kumagai S.

    J Epidemiol   2018.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2188/jea.JE20170012

  • Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes Reviewed International journal

    Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD Jr, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, den Hoed M, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jiménez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O'Donnell MJ, Psaty BM, Pulit SL, Rannikmäe K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, et al.

    Nat Genet   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41588-018-0058-3

  • Insulin resistance and clinical outcomes after acute ischemic stroke Reviewed International journal

    Ago T, Matsuo R, Hata J, Wakisaka Y, Kuroda J, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators.

    Neurology   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/WNL.0000000000005358

  • Clustering of risk factors and the risk of incident cardiovascular disease in asian and caucasian populations: results from the Asia Pacific Cohort Studies Collaboration Reviewed International journal

    Peters SAE, Wang X, Lam TH, Kim HC, Ho S, Ninomiya T, Knuiman M, Vaartjes I, Bots ML, Woodward M; Asia Pacific Cohort Studies Collaboration.

    BMJ Open   2018.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/bmjopen-2017-019335

  • Prevalence and risk factors for polypoidal choroidal vasculopathy in a general Japanese population: the Hisayama Study Reviewed International journal

    Fujiwara K, Yasuda M, Hata J, Oshima Y, Hashimoto S, Yoshitomi T, Kiyohara Y, Ishibashi T, Ninomiya T, Sonoda KH.

    Semin Ophthalmol   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/08820538.2018.1506483

  • Albuminuria increases the risks for both Alzheimer disease and vascular dementia in community-dwelling Japanese elderly: the Hisayama Study Reviewed International journal

    Takae K, Hata J, Ohara T, Yoshida D, Shibata M, Mukai N, Hirakawa Y, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T.

    J Am Heart Assoc   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/JAHA.117.006693

  • The ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cancer death in a Japanese community: the Hisayama Study Reviewed

    Nagata M, Hata J, Hirakawa Y, Mukai N, Yoshida D, Ohara T, Kishimoto H, Kawano H, Kitazono T, Kiyohara Y, Ninomiya T.

    J Epidemiol   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.je.2017.01.004

  • Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Lancet   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0140-6736(17)32129-3

  • Association between onset-to-door time and clinical outcomes after ischemic stroke Reviewed International journal

    Matsuo R, Yamaguchi Y, Matsushita T, Hata J, Kiyuna F, Fukuda K, Wakisaka Y, Kuroda J, Ago T, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators.

    Stroke   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.117.018132

  • Association of airflow limitation with carotid atherosclerosis in a Japanese community: the Hisayama Study Reviewed

    Kudo K, Hata J, Matsumoto K, Shundo Y, Fukuyama S, Inoue H, Kitazono T, Kiyohara Y, Ninomiya T, Nakanishi Y.

    Circ J   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-16-1305

  • Morning and evening blood pressures are associated with intima-media thickness in a general population: the Hisayama Study Reviewed

    Sakata S, Hata J, Fukuhara M, Yonemoto K, Mukai N, Yoshida D, Kishimoto H, Ohtsubo T, Kitazono T, Kiyohara Y, Ninomiya T.

    Circ J   2017.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-16-1306

  • Alternative measures of hyperglycemia and risk of Alzheimer's disease in the community: the Hisayama Study Reviewed International journal

    Mukai N, Ohara T, Hata J, Hirakawa Y, Yoshida D, Kishimoto H, Koga M, Nakamura U, Kitazono T, Kiyohara Y, Ninomiya T.

    J Clin Endocrinol Metab   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/jc.2017-00439

  • Association between serum vitamin D and all-cause and cause-specific death in a general Japanese population: the Hisayama Study Reviewed

    Umehara K, Mukai N, Hata J, Hirakawa Y, Ohara T, Yoshida D, Kishimoto H, Kitazono T, Hoka S, Kiyohara Y, Ninomiya T.

    Circ J   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-16-0954

  • Left atrial size and long-term risk of recurrent stroke after acute ischemic stroke in patients with nonvalvular atrial fibrillation Reviewed International journal

    Ogata T, Matsuo R, Kiyuna F, Hata J, Ago T, Tsuboi Y, Kitazono T, Kamouchi M; FSR Investigators.

    J Am Heart Assoc   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/JAHA.117.006402

  • Day-to-day blood pressure variability and risk of dementia in a general Japanese elderly population: the Hisayama Study Reviewed International journal

    Oishi E, Ohara T, Sakata S, Fukuhara M, Hata J, Yoshida D, Shibata M, Ohtsubo T, Kitazono T, Kiyohara Y, Ninomiya T.

    Circulation   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/CIRCULATIONAHA.116.025667

  • Prognostic value of variability in systolic blood pressure related to vascular events and premature death in type 2 diabetes mellitus: the ADVANCE-ON Study Reviewed International journal

    Ohkuma T, Woodward M, Jun M, Muntner P, Hata J, Colagiuri S, Harrap S, Mancia G, Poulter N, Williams B, Rothwell P, Chalmers J; ADVANCE Collaborative Group.

    Hypertension   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/HYPERTENSIONAHA.117.09359

  • Serum non-high-density lipoprotein cholesterol and risk of cardiovascular disease in community dwellers with chronic kidney disease: the Hisayama Study Reviewed

    Usui T, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Kitazono T, Kiyohara Y, Ninomiya T.

    J Atheroscler Thromb   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5551/jat.37044

  • Dietary protein intake and stroke risk in a general Japanese population: the Hisayama Study Reviewed International journal

    Ozawa M, Yoshida D, Hata J, Ohara T, Mukai N, Shibata M, Uchida K, Nagata M, Kitazono T, Kiyohara Y, Ninomiya T.

    Stroke   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.116.016059

  • Tooth loss and risk of dementia in the community: the Hisayama Study Reviewed International journal

    Takeuchi K, Ohara T, Furuta M, Takeshita T, Shibata Y, Hata J, Yoshida D, Yamashita Y, Ninomiya T.

    J Am Geriatr Soc   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgs.14791

  • Trends in dementia prevalence, incidence, and survival rate in a Japanese community Reviewed International journal

    Ohara T, Hata J, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y, Ninomiya T.

    Neurology   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/WNL.0000000000003932

  • Intracerebral hemorrhage location and outcome among INTERACT2 participants Reviewed International journal

    Delcourt C, Sato S, Zhang S, Sandset EC, Zheng D, Chen X, Hackett ML, Arima H, Hata J, Heeley E, Al-Shahi Salman R, Robinson T, Davies L, Lavados PM, Lindley RI, Stapf C, Chalmers J, Anderson CS; INTERACT2 Investigators.

    Neurology   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/WNL.0000000000003771

  • Genetic predisposition to ischemic stroke: a polygenic risk score Reviewed International journal

    Hachiya T, Kamatani Y, Takahashi A, Hata J, Furukawa R, Shiwa Y, Yamaji T, Hara M, Tanno K, Ohmomo H, Ono K, Takashima N, Matsuda K, Wakai K, Sawada N, Iwasaki M, Yamagishi K, Ago T, Ninomiya T, Fukushima A, Hozawa A, Minegishi N, Satoh M, Endo R, Sasaki M, Sakata K, Kobayashi S, Ogasawara K, Nakamura M, Hitomi J, Kita Y, Tanaka K, Iso H, Kitazono T, Kubo M, Tanaka H, Tsugane S, Kiyohara Y, Yamamoto M, Sobue K, Shimizu A.

    Stroke   2017.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.116.014506

  • Adverse influence of pre-stroke dementia on short-term functional outcomes in patients with acute ischemic stroke: the Fukuoka Stroke Registry Reviewed International journal

    Wakisaka Y, Matsuo R, Hata J, Kuroda J, Kitazono T, Kamouchi M, Ago T; Fukuoka Stroke Registry Investigators.

    Cerebrovasc Dis   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000453625

  • Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Lancet   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0140-6736(16)31919-5

  • Associations with health-related quality of life after intracerebral haemorrhage: pooled analysis of INTERACT studies Reviewed International journal

    Delcourt C, Zheng D, Chen X, Hackett M, Arima H, Hata J, Heeley E, Al-Shahi Salman R, Woodward M, Huang Y, Robinson T, Lavados PM, Lindley RI, Stapf C, Davies L, Chalmers J, Anderson CS, Sato S; INTERACT Investigators.

    J Neurol Neurosurg Psychiatry   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/jnnp-2016-314414

  • Combination of helicobacter pylori antibody and serum pepsinogen as a good predictive tool of gastric cancer incidence: 20-year prospective data from the Hisayama Study Reviewed

    Ikeda F, Shikata K, Hata J, Fukuhara M, Hirakawa Y, Ohara T, Mukai N, Nagata M, Yoshida D, Yonemoto K, Esaki M, Kitazono T, Kiyohara Y, Ninomiya T.

    J Epidemiol   2016.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2188/jea.JE20150258

  • The development of a risk score for incident atrial fibrillation in Japanese general population cohorts: a collaborative meta-analysis Reviewed International journal

    Kokubo Yoshihiro, Imano Hironori, Hata Jun, Murakoshi Nobuyuki, Aizawa Yoshifusa, Iso Hiroyasu, Ninomiya Toshiharu, Nakamura Fumiaki, Miyamoto Yoshihiro, Okamura Tomonori, Tomita Hirofumi, Okumura Ken

    CIRCULATION   134   2016.11

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    DOI: 10.1253/circj.CJ-17-0277

  • PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice Reviewed International journal

    Torisu K, Zhang X, Nonaka M, Kaji T, Tsuchimoto D, Kajitani K, Sakumi K, Torisu T, Chida K, Sueishi K, Kubo M, Hata J, Kitazono T, Kiyohara Y, Nakabeppu Y.

    Genes Cells   2016.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/gtc.12402

  • Association between diabetes and hippocampal atrophy in elderly Japanese: the Hisayama Study Reviewed International journal

    Hirabayashi N, Hata J, Ohara T, Mukai N, Nagata M, Shibata M, Gotoh S, Furuta Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Kiyohara Y, Ninomiya T.

    Diabetes Care   2016.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/dc15-2800

  • Prognostic significance of hyponatremia in acute intracerebral hemorrhage: pooled analysis of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial Studies Reviewed International journal

    Carcel C, Sato S, Zheng D, Heeley E, Arima H, Yang J, Wu G, Chen G, Zhang S, Delcourt C, Lavados P, Robinson T, Lindley RI, Wang X, Chalmers J, Anderson CS; Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial 2 Investigators.

    Crit Care Med   2016.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/CCM.0000000000001628

  • A century of trends in adult human height Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Elife   2016.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.7554/eLife.13410

  • Serum uric acid as a risk factor for chronic kidney disease in a Japanese community: the Hisayama Study Reviewed

    Takae K, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T.

    Circ J   2016.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.CJ-16-0030

  • Estimated GFR and the effect of intensive blood pressure lowering after acute intracerebral hemorrhage Reviewed International journal

    Zheng D, Sato S, Arima H, Heeley E, Delcourt C, Cao Y, Chalmers J, Anderson CS; INTERACT2 Investigators.

    Am J Kidney Dis   2016.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1053/j.ajkd.2016.01.020

  • Foveal and macular thickness in a Japanese population: the Hisayama Study Reviewed International journal

    Hashimoto S, Yasuda M, Ninomiya T, Hata J, Yoshida D, Tahara-Asakuma T, Hirakawa Y, Arakawa S, Fujiwara K, Kiyohara Y, Ishibashi T.

    Ophthalmic Epidemiol   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3109/09286586.2015.1136651

  • Plasma C-reactive protein and clinical outcomes after acute ischemic stroke: a prospective observational study Reviewed International journal

    Matsuo R, Ago T, Hata J, Wakisaka Y, Kuroda J, Kuwashiro T, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators.

    PLoS One   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0156790

  • Elevated 2-hour post-load glucose levels and longer duration of diabetes are risk factors for hippocampal atrophy in elderly Japanese: the Hisayama Study Reviewed International journal

    Naoki Hirabayashi, Jun Hata, Tomoyuki Ohara, Naoko Mukai, Masaharu Nagata, Mao Shibata, Seiji Goto, Yoshihiko Furuta, Fumio Yamashita, Kazufumi Yoshihara, Takanari Kitazono, Nobuyuki Sudo, Yutaka Kiyohara, Toshiharu Ninomiya

    DIABETES   65   A361 - A361   2016.6

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    DOI: 10.2337/dc15-2800

  • Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants Reviewed International journal

    NCD Risk Factor Collaboration (NCD-RisC).

    Lancet   2016.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0140-6736(16)00618-8

  • The long-term association between physical activity and risk of dementia in the community: the Hisayama Study Reviewed International journal

    Kishimoto H, Ohara T, Hata J, Ninomiya T, Yoshida D, Mukai N, Nagata M, Ikeda F, Fukuhara M, Kumagai S, Kanba S, Kitazono T, Kiyohara Y.

    Eur J Epidemiol   2016.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10654-016-0125-y

  • Low ambient temperature and intracerebral hemorrhage: the INTERACT2 study Reviewed International journal

    Zheng D, Arima H, Sato S, Gasparrini A, Heeley E, Delcourt C, Lo S, Huang Y, Wang J, Stapf C, Robinson T, Lavados P, Chalmers J, Anderson CS; INTERACT2 Investigators.

    PLoS One   2016.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0149040

  • Determinants and prognostic significance of hematoma sedimentation levels in acute intracerebral hemorrhage Reviewed International journal

    Sato S, Delcourt C, Zhang S, Arima H, Heeley E, Zheng D, Al-Shahi Salman R, Stapf C, Tzourio C, Robinson T, Lindley RI, Chalmers J, Anderson CS; INTERACT2 Investigators.

    Cerebrovasc Dis   2016.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000442532

  • Adjustment of cell-type composition minimizes systematic bias in blood dna methylation profiles derived by DNA collection protocols Reviewed International journal

    Shiwa Y, Hachiya T, Furukawa R, Ohmomo H, Ono K, Kudo H, Hata J, Hozawa A, Iwasaki M, Matsuda K, Minegishi N, Satoh M, Tanno K, Yamaji T, Wakai K, Hitomi J, Kiyohara Y, Kubo M, Tanaka H, Tsugane S, Yamamoto M, Sobue K, Shimizu A.

    PLoS One   2016.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0147519

  • Influence of statin pretreatment on initial neurological severity and short-term functional outcome in acute ischemic stroke patients: the Fukuoka Stroke Registry Reviewed International journal

    Ishikawa H, Wakisaka Y, Matsuo R, Makihara N, Hata J, Kuroda J, Ago T, Kitayama J, Nakane H, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators.

    Cerebrovasc Dis   2016.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000447718

  • Causes of ischemic stroke in patients with non-valvular atrial fibrillation Reviewed International journal

    Nakamura A, Kuroda J, Ago T, Hata J, Matsuo R, Arakawa S, Kuwashiro T, Yasaka M, Okada Y, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators.

    Cerebrovasc Dis   2016.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000445723

  • Insulin resistance is a risk factor for increased intraocular pressure: the Hisayama Study Reviewed International journal

    Fujiwara K, Yasuda M, Ninomiya T, Hata J, Hashimoto S, Yoshitomi T, Kiyohara Y, Ishibashi T.

    Invest Ophthalmol Vis Sci   2015.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1167/iovs.15-16766

  • Higher mortality in patients with right hemispheric intracerebral haemorrhage: INTERACT1 and 2 Reviewed International journal

    Sato S, Heeley E, Arima H, Delcourt C, Hirakawa Y, Pamidimukkala V, Li Z, Tao Q, Xu Y, Hennerici MG, Robinson T, Tzourio C, Lindley RI, Chalmers J, Anderson CS; INTERACT Investigators, Anderson CS, Huang Y, Wang JG, Arima H, Neal B, Peng B, Heeley E, Skulina C, Parsons MW, Kim JS, Tao QL, Li YC, Jiang JD, Tai LW, Zhang LJ, Xu E, Cheng Y, Heritier S, Morgenstern LB, Chalmers J.

    J Neurol Neurosurg Psychiatry   2015.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/jnnp-2014-309870

  • Midlife and late-life smoking and risk of dementia in the community: the Hisayama Study Reviewed International journal

    Ohara T, Ninomiya T, Hata J, Ozawa M, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y.

    J Am Geriatr Soc   2015.11

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    DOI: 10.1111/jgs.13794

  • Hematocrit and the risk of cardiovascular disease in a Japanese community: the Hisayama Study Reviewed International journal

    Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Ago T, Kitazono T, Kiyohara Y.

    Atherosclerosis   2015.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.atherosclerosis.2015.07.014

  • Day-by-day blood pressure variability and functional outcome after acute ischemic stroke: Fukuoka Stroke Registry Reviewed International journal

    Fukuda K, Kai H, Kamouchi M, Hata J, Ago T, Nakane H, Imaizumi T, Kitazono T; FSR Investigators.

    Stroke   2015.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.115.009076

  • Covariate-adjusted measures of discrimination for survival data Reviewed International journal

    White IR, Rapsomaniki E; Emerging Risk Factors Collaboration.

    Biom J   2015.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/bimj.201400061

  • Association of hemoglobin A1c and glycated albumin with carotid atherosclerosis in community-dwelling Japanese subjects: the Hisayama Study Reviewed International journal

    Mukai N, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y.

    Cardiovasc Diabetol   2015.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12933-015-0247-7

  • Optimal achieved blood pressure in acute intracerebral hemorrhage: INTERACT2 Reviewed International journal

    Arima H, Heeley E, Delcourt C, Hirakawa Y, Wang X, Woodward M, Robinson T, Stapf C, Parsons M, Lavados PM, Huang Y, Wang J, Chalmers J, Anderson CS; INTERACT2 Investigators.

    Neurology   2015.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/WNL.0000000000001205

  • Sex differences in short-term outcomes after acute ischemic stroke: the Fukuoka Stroke Registry Reviewed International journal

    Irie F, Kamouchi M, Hata J, Matsuo R, Wakisaka Y, Kuroda J, Ago T, Kitazono T; FSR Investigators.

    Stroke   2015.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.114.006739

  • Angiotensin I-converting enzyme gene polymorphism enhances the effect of hypercholesterolemia on the risk of coronary heart disease in a general Japanese population: the Hisayama Study Reviewed

    Kondo H, Ninomiya T, Hata J, Hirakawa Y, Yonemoto K, Arima H, Nagata M, Tsuruya K, Kitazono T, Kiyohara Y.

    J Atheroscler Thromb   2015.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5551/jat.24166

  • Effects of hydrochlorothiazide on oxidative stress and pulse pressure in hypertensive patients with chronic stroke: the EMINENT Study Reviewed

    Nakane H, Kamouchi M, Hata J, Ibayashi S, Kusuda K, Omae T, Nagao T, Ago T, Kitazono T; EMINENT Study Investigators.

    Intern Med   2015.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.54.2631

  • Off-hour admission and outcomes in patients with acute intracerebral hemorrhage in the INTERACT2 trial Reviewed International journal

    Sato S, Arima H, Heeley E, Hirakawa Y, Delcourt C, Lindley RI, Robinson T, Huang Y, Morgenstern L, Stapf C, Wang J, Chalmers J, Anderson CS; INTERACT2 Investigators.

    Cerebrovasc Dis   2015.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000434690

  • Thrombolytic therapy with intravenous recombinant tissue plasminogen activator in Japanese older patients with acute ischemic stroke: Fukuoka Stroke Registry Reviewed International journal

    Matsuo R, Kamouchi M, Ago T, Hata J, Shono Y, Kuroda J, Wakisaka Y, Sugimori H, Kitazono T; FSR investigators.

    Geriatr Gerontol Int   2014.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ggi.12205

  • Intravenous thrombolysis with recombinant tissue plasminogen activator for ischemic stroke patients over 80 years old: the Fukuoka Stroke Registry Reviewed International journal

    Matsuo R, Kamouchi M, Fukuda H, Hata J, Wakisaka Y, Kuroda J, Ago T, Kitazono T; FSR Investigators.

    PLoS One   2014.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0110444

  • Significance of plasma adiponectin for diagnosis, neurological severity and functional outcome in ischemic stroke: Research for Biomarkers in Ischemic Stroke (REBIOS) Reviewed International journal

    Kuwashiro T, Ago T, Kamouchi M, Matsuo R, Hata J, Kuroda J, Fukuda K, Sugimori H, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T.

    Metabolism   2014.9

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    DOI: 10.1016/j.metabol.2014.04.012

  • Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment Reviewed International journal

    Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration.

    Lancet Diabetes Endocrinol   2014.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S2213-8587(14)70102-0

  • Gastrointestinal bleeding in acute ischemic stroke: recent trends from the Fukuoka Stroke Registry Reviewed International journal

    Ogata T, Kamouchi M, Matsuo R, Hata J, Kuroda J, Ago T, Sugimori H, Inoue T, Kitazono T; Fukuoka Stroke Registry.

    Cerebrovasc Dis Extra   2014.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000365245

  • Midlife and late-life handgrip strength and risk of cause-specific death in a general Japanese population: the Hisayama Study Reviewed International journal

    Kishimoto H, Hata J, Ninomiya T, Nemeth H, Hirakawa Y, Yoshida D, Kumagai S, Kitazono T, Kiyohara Y.

    J Epidemiol Community Health   2014.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/jech-2013-203611

  • Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama Study Reviewed International journal

    Ozawa M, Ohara T, Ninomiya T, Hata J, Yoshida D, Mukai N, Nagata M, Uchida K, Shirota T, Kitazono T, Kiyohara Y.

    J Am Geriatr Soc   2014.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jgs.12887

  • Impact of the 1425G/A polymorphism of PRKCH on the recurrence of ischemic stroke: Fukuoka Stroke Registry Reviewed International journal

    Matsuo R, Ago T, Hata J, Kuroda J, Wakisaka Y, Sugimori H, Kitazono T, Kamouchi M; FSR Investigators.

    J Stroke Cerebrovasc Dis   2014.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jstrokecerebrovasdis.2013.11.011

  • Plasma S100A12 is associated with functional outcome after ischemic stroke: Research for Biomarkers in Ischemic Stroke Reviewed International journal

    Wakisaka Y, Ago T, Kamouchi M, Kuroda J, Matsuo R, Hata J, Gotoh S, Isomura T, Awano H, Suzuki K, Fukuda K, Okada Y, Kiyohara Y, Ooboshi H, Kitazono T; REBIOS Investigators.

    J Neurol Sci   2014.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jns.2014.02.031

  • Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population: the Hisayama Study Reviewed International journal

    Imamura T, Doi Y, Ninomiya T, Hata J, Nagata M, Ikeda F, Mukai N, Hirakawa Y, Yoshida D, Fukuhara M, Kitazono T, Kiyohara Y.

    Atherosclerosis   2014.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.atherosclerosis.2014.01.005

  • Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1.8 million participants Reviewed International journal

    Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration (BMI Mediated Effects), Lu Y, Hajifathalian K, Ezzati M, Woodward M, Rimm EB, Danaei G.

    Lancet   2014.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0140-6736(13)61836-X

  • Glycated hemoglobin measurement and prediction of cardiovascular disease Reviewed International journal

    Emerging Risk Factors Collaboration, Di Angelantonio E, Gao P, Khan H, Butterworth AS, Wormser D, Kaptoge S, Kondapally Seshasai SR, Thompson A, Sarwar N, Willeit P, Ridker PM, Barr EL, Khaw KT, Psaty BM, Brenner H, Balkau B, Dekker JM, Lawlor DA, Daimon M, Willeit J, Njølstad I, Nissinen A, Brunner EJ, Kuller LH, Price JF, Sundström J, Knuiman MW, Feskens EJ, Verschuren WM, Wald N, Bakker SJ, Whincup PH, Ford I, Goldbourt U, Gómez-de-la-Cámara A, Gallacher J, Simons LA, Rosengren A, Sutherland SE, Björkelund C, Blazer DG, Wassertheil-Smoller S, Onat A, Marín Ibañez A, Casiglia E, Jukema JW, Simpson LM, Giampaoli S, Nordestgaard BG, Selmer R, Wennberg P, Kauhanen J, Salonen JT, Dankner R, Barrett-Connor E, Kavousi M, Gudnason V, Evans D, Wallace RB, Cushman M, D'Agostino RB Sr, Umans JG, Kiyohara Y, Nakagawa H, Sato S, Gillum RF, Folsom AR, van der Schouw YT, Moons KG, Griffin SJ, Sattar N, Wareham NJ, Selvin E, Thompson SG, Danesh J.

    JAMA   2014.3

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    DOI: 10.1001/jama.2014.1873

  • Trends in the prevalence of type 2 diabetes and prediabetes in community-dwelling Japanese subjects: the Hisayama Study Reviewed International journal

    Mukai N, Doi Y, Ninomiya T, Hirakawa Y, Nagata M, Yoshida D, Hata J, Fukuhara M, Nakamura U, Kitazono T, Kiyohara Y.

    J Diabetes Investig   2014.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jdi.12136

  • ABCD3 and ABCD3-I scores are superior to ABCD2 score in the prediction of short- and long-term risks of stroke after transient ischemic attack Reviewed International journal

    Kiyohara T, Kamouchi M, Kumai Y, Ninomiya T, Hata J, Yoshimura S, Ago T, Okada Y, Kitazono T; Fukuoka Stroke Registry Investigators.

    Stroke   2014.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.113.003077

  • Thresholds of various glycemic measures for diagnosing diabetes based on prevalence of retinopathy in community-dwelling Japanese subjects: the Hisayama Study Reviewed International journal

    Mukai N, Yasuda M, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y.

    Cardiovasc Diabetol   2014.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1475-2840-13-45

  • Trends in the incidence and survival of intracerebral hemorrhage by its location in a Japanese community Reviewed

    Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Shikata K, Kamouchi M, Kitazono T, Kiyohara Y.

    Circ J   2014.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1253/circj.cj-13-0811

  • High blood pressure after acute ischemic stroke is associated with poor clinical outcomes: Fukuoka Stroke Registry Reviewed International journal

    Ishitsuka K, Kamouchi M, Hata J, Fukuda K, Matsuo R, Kuroda J, Ago T, Kuwashiro T, Sugimori H, Nakane H, Kitazono T; FSR Investigators.

    Hypertension   2014.1

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    DOI: 10.1161/HYPERTENSIONAHA.113.02189

  • A low ankle brachial index is associated with an increased risk of cardiovascular disease: the Hisayama Study Reviewed

    Kojima I, Ninomiya T, Hata J, Fukuhara M, Hirakawa Y, Mukai N, Yoshida D, Kitazono T, Kiyohara Y.

    J Atheroscler Thromb   2014.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5551/jat.22608

  • Magnesium intake decreases type 2 diabetes risk through the improvement of insulin resistance and inflammation: the Hisayama Study Reviewed International journal

    Hata A, Doi Y, Ninomiya T, Mukai N, Hirakawa Y, Hata J, Ozawa M, Uchida K, Shirota T, Kitazono T, Kiyohara Y.

    Diabet Med   2013.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/dme.12250

  • Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: the Hisayama Study Reviewed International journal

    Ninomiya T, Nagata M, Hata J, Hirakawa Y, Ozawa M, Yoshida D, Ohara T, Kishimoto H, Mukai N, Fukuhara M, Kitazono T, Kiyohara Y.

    Atherosclerosis   2013.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.atherosclerosis.2013.09.023

  • Statins and the risks of stroke recurrence and death after ischemic stroke: the Fukuoka Stroke Registry Reviewed International journal

    Makihara N, Kamouchi M, Hata J, Matsuo R, Ago T, Kuroda J, Kuwashiro T, Sugimori H, Kitazono T; Fukuoka Stroke Registry Investigators.

    Atherosclerosis   2013.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.atherosclerosis.2013.09.017

  • Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general Japanese population: the Hisayama Study Reviewed International journal

    Ikeda F, Doi Y, Ninomiya T, Hirakawa Y, Mukai N, Hata J, Shikata K, Yoshida D, Matsumoto T, Kitazono T, Kiyohara Y.

    Cardiovasc Diabetol   2013.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1475-2840-12-164

  • Intensity of anticoagulation and clinical outcomes in acute cardioembolic stroke: the Fukuoka Stroke Registry Reviewed International journal

    Nakamura A, Ago T, Kamouchi M, Hata J, Matsuo R, Kuroda J, Kuwashiro T, Sugimori H, Kitazono T; Fukuoka Stroke Registry Investigators.

    Stroke   2013.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.113.002523

  • Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: a cross-sectional study Reviewed International journal

    Sekita A, Arima H, Ninomiya T, Ohara T, Doi Y, Hirakawa Y, Fukuhara M, Hata J, Yonemoto K, Ga Y, Kitazono T, Kanba S, Kiyohara Y.

    BMC Public Health   2013.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1471-2458-13-862

  • Temporal trends in sudden unexpected death in a general population: the Hisayama Study Reviewed International journal

    Nagata M, Ninomiya T, Doi Y, Hata J, Ikeda F, Mukai N, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y.

    Am Heart J   2013.6

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    DOI: 10.1016/j.ahj.2013.02.028

  • Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage Reviewed International journal

    Anderson CS, Heeley E, Huang Y, Wang J, Stapf C, Delcourt C, Lindley R, Robinson T, Lavados P, Neal B, Hata J, Arima H, Parsons M, Li Y, Wang J, Heritier S, Li Q, Woodward M, Simes RJ, Davis SM, Chalmers J; INTERACT2 Investigators.

    N Engl J Med   2013.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1056/NEJMoa1214609

  • White-coat and masked hypertension are associated with carotid atherosclerosis in a general population: the Hisayama Study Reviewed International journal

    Fukuhara M, Arima H, Ninomiya T, Hata J, Hirakawa Y, Doi Y, Yonemoto K, Mukai N, Nagata M, Ikeda F, Matsumura K, Kitazono T, Kiyohara Y.

    Stroke   2013.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.111.000704

  • The global cardiovascular risk transition: associations of four metabolic risk factors with national income, urbanization, and western diet in 1980 and 2008 Reviewed International journal

    Danaei G, Singh GM, Paciorek CJ, Lin JK, Cowan MJ, Finucane MM, Farzadfar F, Stevens GA, Riley LM, Lu Y, Rao M, Ezzati M; Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group.

    Circulation   2013.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/CIRCULATIONAHA.113.001470

  • Clinical significance of plasma vegf value in ischemic stroke: Research for Biomarkers in Ischemic Stroke (REBIOS) Study Reviewed International journal

    Matsuo R, Ago T, Kamouchi M, Kuroda J, Kuwashiro T, Hata J, Sugimori H, Fukuda K, Gotoh S, Makihara N, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T.

    BMC Neurol   2013.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1471-2377-13-32

  • Brachial-ankle pulse wave velocity predicts the development of cardiovascular disease in a general Japanese population: the Hisayama Study Reviewed International journal

    Ninomiya T, Kojima I, Doi Y, Fukuhara M, Hirakawa Y, Hata J, Kitazono T, Kiyohara Y.

    J Hypertens   2013.3

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    DOI: 10.1097/HJH.0b013e32835c5c23

  • Angiopoietin-like protein 2 is associated with chronic kidney disease in a general Japanese population: the Hisayama Study Reviewed

    Usui T, Ninomiya T, Nagata M, Takahashi O, Doi Y, Hata J, Fukuhara M, Kitazono T, Oike Y, Kiyohara Y.

    Circ J   2013.1

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    DOI: 10.1253/circj.cj-12-1548

  • Angiopoietin-like protein 2 and risk of type 2 diabetes in a general Japanese population: the Hisayama Study Reviewed International journal

    Doi Y, Ninomiya T, Hirakawa Y, Takahashi O, Mukai N, Hata J, Iwase M, Kitazono T, Oike Y, Kiyohara Y.

    Diabetes Care   2013.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/dc12-0166

  • Prediction of kidney-related outcomes in patients with type 2 diabetes Reviewed International journal

    Jardine MJ, Hata J, Woodward M, Perkovic V, Ninomiya T, Arima H, Zoungas S, Cass A, Patel A, Marre M, Mancia G, Mogensen CE, Poulter N, Chalmers J; ADVANCE Collaborative Group.

    Am J Kidney Dis   2012.11

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    DOI: 10.1053/j.ajkd.2012.04.025

  • Association between glucose tolerance level and cancer death in a general Japanese population: the Hisayama Study Reviewed International journal

    Hirakawa Y, Ninomiya T, Mukai N, Doi Y, Hata J, Fukuhara M, Iwase M, Kitazono T, Kiyohara Y.

    Am J Epidemiol   2012.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/aje/kws178

  • Resting heart rate and the risk of microvascular complications in patients with type 2 diabetes mellitus Reviewed International journal

    Hillis GS, Hata J, Woodward M, Perkovic V, Arima H, Chow CK, Zoungas S, Patel A, Poulter NR, Mancia G, Williams B, Chalmers J.

    J Am Heart Assoc   2012.10

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    DOI: 10.1161/JAHA.112.002832

  • Self-reported dietary intake of potassium, calcium, and magnesium and risk of dementia in the Japanese: the Hisayama Study Reviewed International journal

    Ozawa M, Ninomiya T, Ohara T, Hirakawa Y, Doi Y, Hata J, Uchida K, Shirota T, Kitazono T, Kiyohara Y.

    J Am Geriatr Soc   2012.8

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    DOI: 10.1111/j.1532-5415.2012.04061.x

  • Smoking cessation improves mortality in Japanese men: the Hisayama Study Reviewed International journal

    Ikeda F, Ninomiya T, Doi Y, Hata J, Fukuhara M, Matsumoto T, Kiyohara Y.

    Tob Control   2012.7

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    DOI: 10.1136/tc.2010.039362

  • Proteinuria and clinical outcomes after ischemic stroke Reviewed International journal

    Kumai Y, Kamouchi M, Hata J, Ago T, Kitayama J, Nakane H, Sugimori H, Kitazono T; FSR Investigators.

    Neurology   2012.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/WNL.0b013e318259e110

  • Optimal cutoff value of the serum pepsinogen level for prediction of gastric cancer incidence: the Hisayama Study Reviewed International journal

    Shikata K, Ninomiya T, Yonemoto K, Ikeda F, Hata J, Doi Y, Fukuhara M, Matsumoto T, Iida M, Kitazono T, Kiyohara Y.

    Scand J Gastroenterol   2012.6

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    DOI: 10.3109/00365521.2012.658855

  • Impact of lower range of prehypertension on cardiovascular events in a general population: the Hisayama Study Reviewed International journal

    Fukuhara M, Arima H, Ninomiya T, Hata J, Yonemoto K, Doi Y, Hirakawa Y, Matsumura K, Kitazono T, Kiyohara Y.

    J Hypertens   2012.5

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    DOI: 10.1097/HJH.0b013e328351d380

  • Dietary vitamin a intake and incidence of gastric cancer in a general Japanese population: the Hisayama Study Reviewed International journal

    Miyazaki M, Doi Y, Ikeda F, Ninomiya T, Hata J, Uchida K, Shirota T, Matsumoto T, Iida M, Kiyohara Y.

    Gastric Cancer   2012.4

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    DOI: 10.1007/s10120-011-0092-7

  • White blood cell count and risk of gastric cancer incidence in a general Japanese population: the Hisayama Study Reviewed International journal

    Iida M, Ikeda F, Ninomiya T, Yonemoto K, Doi Y, Hata J, Matsumoto T, Iida M, Kiyohara Y.

    Am J Epidemiol   2012.3

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    DOI: 10.1093/aje/kwr345

  • The factors associated with a functional outcome after ischemic stroke in diabetic patients: the Fukuoka Stroke Registry Reviewed International journal

    Kuwashiro T, Kamouchi M, Ago T, Hata J, Sugimori H, Kitazono T.

    J Neurol Sci   2012.2

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    DOI: 10.1016/j.jns.2011.09.012

  • Cut-off values of fasting and post-load plasma glucose and HbA1c for predicting type 2 diabetes in community-dwelling Japanese subjects: the Hisayama Study Reviewed International journal

    Mukai N, Doi Y, Ninomiya T, Hata J, Hirakawa Y, Fukuhara M, Iwase M, Kiyohara Y.

    Diabet Med   2012.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1464-5491.2011.03378.x

  • Two risk score models for predicting incident type 2 diabetes in Japan Reviewed International journal

    Doi Y, Ninomiya T, Hata J, Hirakawa Y, Mukai N, Iwase M, Kiyohara Y.

    Diabet Med   2012.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1464-5491.2011.03376.x

  • Prevalence and causes of functional disability in an elderly general population of Japanese: the Hisayama Study Reviewed

    Yoshida D, Ninomiya T, Doi Y, Hata J, Fukuhara M, Ikeda F, Mukai N, Kiyohara Y.

    J Epidemiol   2012.1

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    DOI: 10.2188/jea.je20110083

  • Insulin resistance and the development of cardiovascular disease in a Japanese community: the Hisayama Study Reviewed

    Gotoh S, Doi Y, Hata J, Ninomiya T, Mukai N, Fukuhara M, Kamouchi M, Kitazono T, Kiyohara Y.

    J Atheroscler Thromb   2012.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5551/jat.13698

  • N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in a Japanese community: the Hisayama Study Reviewed International journal

    Doi Y, Ninomiya T, Hata J, Hirakawa Y, Mukai N, Ikeda F, Fukuhara M, Iwase M, Kiyohara Y.

    Arterioscler Thromb Vasc Biol   2011.12

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    DOI: 10.1161/ATVBAHA.111.223669

  • Prestroke glycemic control is associated with the functional outcome in acute ischemic stroke: the Fukuoka Stroke Registry Reviewed International journal

    Kamouchi M, Matsuki T, Hata J, Kuwashiro T, Ago T, Sambongi Y, Fukushima Y, Sugimori H, Kitazono T; FSR Investigators.

    Stroke   2011.10

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    DOI: 10.1161/STROKEAHA.111.617415

  • Glucose tolerance status and risk of dementia in the community: the Hisayama Study Reviewed International journal

    Ohara T, Doi Y, Ninomiya T, Hirakawa Y, Hata J, Iwaki T, Kanba S, Kiyohara Y.

    Neurology   2011.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/WNL.0b013e31822f0435

  • Association of Alzheimer disease pathology with abnormal lipid metabolism: the Hisayama Study Reviewed International journal

    Matsuzaki T, Sasaki K, Hata J, Hirakawa Y, Fujimi K, Ninomiya T, Suzuki SO, Kanba S, Kiyohara Y, Iwaki T.

    Neurology   2011.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/WNL.0b013e31822e145d

  • Effects of blood pressure lowering on major vascular events among patients with isolated diastolic hypertension: the Perindopril Protection Against Recurrent Stroke Study (PROGRESS) trial Reviewed International journal

    Arima H, Anderson C, Omae T, Woodward M, Hata J, Murakami Y, Macmahon S, Neal B, Chalmers J; PROGRESS Collaborative Group.

    Stroke   2011.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.110.606764

  • Midlife and late-life blood pressure and dementia in Japanese elderly: the Hisayama Study Reviewed International journal

    Ninomiya T, Ohara T, Hirakawa Y, Yoshida D, Doi Y, Hata J, Kanba S, Iwaki T, Kiyohara Y.

    Hypertension   2011.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/HYPERTENSIONAHA.110.163055

  • Apolipoprotein genotype for prediction of Alzheimer's disease in older Japanese: the Hisayama Study Reviewed International journal

    Ohara T, Ninomiya T, Kubo M, Hirakawa Y, Doi Y, Hata J, Iwaki T, Kanba S, Kiyohara Y.

    J Am Geriatr Soc   2011.6

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    DOI: 10.1111/j.1532-5415.2011.03405.x

  • Effectiveness of the salivary occult blood test as a screening method for periodontal status Reviewed International journal

    Shimazaki Y, Akifusa S, Takeshita T, Shibata Y, Doi Y, Hata J, Ninomiya T, Hirakawa Y, Kiyohara Y, Yamashita Y.

    J Periodontol   2011.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1902/jop.2010.100304

  • Body mass index and stroke incidence in a Japanese community: the Hisayama Study Reviewed

    Yonemoto K, Doi Y, Hata J, Ninomiya T, Fukuhara M, Ikeda F, Mukai N, Iida M, Kiyohara Y.

    Hypertens Res   2011.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/hr.2010.220

  • Albuminuria as a risk factor for peripheral arterial disease in a general population: the Hisayama Study Reviewed

    Usui T, Ninomiya T, Nagata M, Doi Y, Hata J, Fukuhara M, Kiyohara Y.

    J Atheroscler Thromb   2011.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5551/jat.7682

  • Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community: the Hisayama Study Reviewed International journal

    Sekita A, Ninomiya T, Tanizaki Y, Doi Y, Hata J, Yonemoto K, Arima H, Sasaki K, Iida M, Iwaki T, Kanba S, Kiyohara Y.

    Acta Psychiatr Scand   2010.10

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    DOI: 10.1111/j.1600-0447.2010.01587.x

  • Circulating resistin is increased with decreasing renal function in a general Japanese population: the Hisayama Study Reviewed International journal

    Kawamura R, Doi Y, Osawa H, Ninomiya T, Hata J, Yonemoto K, Tanizaki Y, Iida M, Makino H, Kiyohara Y.

    Nephrol Dial Transplant   2010.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ndt/gfq155

  • QT interval prolongation and the risks of stroke and coronary heart disease in a general Japanese population: the Hisayama Study Reviewed

    Maebuchi D, Arima H, Doi Y, Ninomiya T, Yonemoto K, Tanizaki Y, Kubo M, Hata J, Matsumura K, Iida M, Kiyohara Y.

    Hypertens Res   2010.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/hr.2010.88

  • Trends in the prevalence of chronic kidney disease and its risk factors in a general Japanese population: the Hisayama Study Reviewed International journal

    Nagata M, Ninomiya T, Doi Y, Yonemoto K, Kubo M, Hata J, Tsuruya K, Iida M, Kiyohara Y.

    Nephrol Dial Transplant   2010.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ndt/gfq062

  • Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama Study Reviewed International journal

    Matsuzaki T, Sasaki K, Tanizaki Y, Hata J, Fujimi K, Matsui Y, Sekita A, Suzuki SO, Kanba S, Kiyohara Y, Iwaki T.

    Neurology   2010.8

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    DOI: 10.1212/WNL.0b013e3181eee25f

  • Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population Reviewed International journal

    Matsushita T, Umeno J, Hirakawa Y, Yonemoto K, Ashikawa K, Amitani H, Ninomiya T, Hata J, Doi Y, Kitazono T, Iida M, Nakamura Y, Kiyohara Y, Kubo M.

    J Hum Genet   2010.7

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    DOI: 10.1038/jhg.2010.45

  • Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke Reviewed International journal

    Matsushita T, Ashikawa K, Yonemoto K, Hirakawa Y, Hata J, Amitani H, Doi Y, Ninomiya T, Kitazono T, Ibayashi S, Iida M, Nakamura Y, Kiyohara Y, Kubo M.

    Hum Mol Genet   2010.3

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    DOI: 10.1093/hmg/ddp582

  • Impact of glucose tolerance status on development of ischemic stroke and coronary heart disease in a general Japanese population: the Hisayama Study Reviewed International journal

    Doi Y, Ninomiya T, Hata J, Fukuhara M, Yonemoto K, Iwase M, Iida M, Kiyohara Y.

    Stroke   2010.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.109.564708

  • Impact of blood pressure levels on different types of stroke: the Hisayama Study Reviewed International journal

    Arima H, Tanizaki Y, Yonemoto K, Doi Y, Ninomiya T, Hata J, Fukuhara M, Matsumura K, Iida M, Kiyohara Y.

    J Hypertens   2009.12

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    DOI: 10.1097/HJH.0b013e328330e882

  • Development and validation of a cardiovascular risk prediction model for Japanese: the Hisayama Study Reviewed

    Arima H, Yonemoto K, Doi Y, Ninomiya T, Hata J, Tanizaki Y, Fukuhara M, Matsumura K, Iida M, Kiyohara Y.

    Hypertens Res   2009.12

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    DOI: 10.1038/hr.2009.161

  • Impact of metabolic syndrome compared with impaired fasting glucose on the development of type 2 diabetes in a general Japanese population: the Hisayama Study Reviewed International journal

    Mukai N, Doi Y, Ninomiya T, Hata J, Yonemoto K, Iwase M, Iida M, Kiyohara Y.

    Diabetes Care   2009.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/dc09-0896

  • Diabetes and hypertension markedly increased the risk of ischemic stroke associated with high serum resistin concentration in a general Japanese population: the Hisayama Study Reviewed International journal

    Osawa H, Doi Y, Makino H, Ninomiya T, Yonemoto K, Kawamura R, Hata J, Tanizaki Y, Iida M, Kiyohara Y.

    Cardiovasc Diabetol   2009.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1475-2840-8-60

  • Flow volume and cross-sectional area of the extracranial vertebral arteries and its relation to vascular lesions or anatomical variations in the posterior circulation Reviewed International journal

    Wakugawa Y, Sugimori H, Nakane H, Hata J, Irie K, Kitazono T, Iida M.

    Ultrasound Med Biol   2009.7

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    DOI: 10.1016/j.ultrasmedbio.2009.01.006

  • Proposed criteria for metabolic syndrome in Japanese based on prospective evidence: the Hisayama Study Reviewed International journal

    Doi Y, Ninomiya T, Hata J, Yonemoto K, Arima H, Kubo M, Tanizaki Y, Iwase M, Iida M, Kiyohara Y.

    Stroke   2009.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.108.531319

  • Lack of association between variations of PDE4D and ischemic stroke in the Japanese population Reviewed International journal

    Matsushita T, Kubo M, Yonemoto K, Ninomiya T, Ashikawa K, Liang B, Hata J, Doi Y, Kitazono T, Ibayashi S, Iida M, Kiyohara Y, Nakamura Y.

    Stroke   2009.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/STROKEAHA.108.527408

  • Hyperglycemia increases risk of gastric cancer posed by helicobacter pylori infection: a population-based cohort study Reviewed International journal

    Ikeda F, Doi Y, Yonemoto K, Ninomiya T, Kubo M, Shikata K, Hata J, Tanizaki Y, Matsumoto T, Iida M, Kiyohara Y.

    Gastroenterology   2009.4

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    DOI: 10.1053/j.gastro.2008.12.045

  • LDL cholesterol and the development of stroke subtypes and coronary heart disease in a general Japanese population: the Hisayama Study Reviewed International journal

    Imamura T, Doi Y, Arima H, Yonemoto K, Hata J, Kubo M, Tanizaki Y, Ibayashi S, Iida M, Kiyohara Y.

    Stroke   2009.2

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    DOI: 10.1161/STROKEAHA.108.529537

  • Seroprevalence of herpes simplex virus 1 and 2 in a population-based cohort in Japan Reviewed

    Doi Y, Ninomiya T, Hata J, Yonemoto K, Tanizaki Y, Arima H, Liu Y, Rahman M, Iida M, Kiyohara Y.

    J Epidemiol   2009.1

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    DOI: 10.2188/jea.je20080061

  • Fasting plasma glucose cutoff for diagnosis of diabetes in a Japanese population Reviewed International journal

    Doi Y, Kubo M, Yonemoto K, Ninomiya T, Iwase M, Arima H, Hata J, Tanizaki Y, Iida M, Kiyohara Y.

    J Clin Endocrinol Metab   2008.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/jc.2007-2819

  • High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese: the Hisayama Study Reviewed International journal

    Arima H, Kubo M, Yonemoto K, Doi Y, Ninomiya T, Tanizaki Y, Hata J, Matsumura K, Iida M, Kiyohara Y.

    Arterioscler Thromb Vasc Biol   2008.7

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    DOI: 10.1161/ATVBAHA.107.157164

  • Polymorphism in the sorbin and SH3-domain-containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population: the Fukuoka Stroke Registry and the Hisayama study Reviewed International journal

    Hagiwara N, Kitazono T, Kamouchi M, Kuroda J, Ago T, Hata J, Ninomiya T, Ooboshi H, Kumai Y, Yoshimura S, Tamaki K, Fujii K, Nagao T, Okada Y, Toyoda K, Nakane H, Sugimori H, Yamashita Y, Wakugawa Y, Kubo M, Tanizaki Y, Kiyohara Y, Ibayashi S, Iida M; Fukuoka Stroke Registry; Hisayama Study.

    Eur J Neurol   2008.5

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    DOI: 10.1111/j.1468-1331.2008.02105.x

  • Polymorphisms in the lymphotoxin alpha gene and the risk of ischemic stroke in the Japanese population. the Fukuoka Stroke Registry and the Hisayama Study Reviewed International journal

    Hagiwara N, Kitazono T, Kamouchi M, Kuroda J, Ago T, Hata J, Ninomiya T, Ooboshi H, Kumai Y, Yoshimura S, Tamaki K, Fujii K, Nagao T, Okada Y, Toyoda K, Nakane H, Sugimori H, Yamashita Y, Wakugawa Y, Kubo M, Tanizaki Y, Kiyohara Y, Ibayashi S, Iida M.

    Cerebrovasc Dis   2008.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000121342

  • Impact of Kir6.2 E23K polymorphism on the development of type 2 diabetes in a general Japanese population: the Hisayama Study Reviewed International journal

    Doi Y, Kubo M, Ninomiya T, Yonemoto K, Iwase M, Arima H, Hata J, Tanizaki Y, Iida M, Kiyohara Y.

    Diabetes   2007.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/db06-1709

  • A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction Reviewed International journal

    Kubo M, Hata J, Ninomiya T, Matsuda K, Yonemoto K, Nakano T, Matsushita T, Yamazaki K, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Sueishi K, Iida M, Nakamura Y, Kiyohara Y.

    Nat Genet   2007.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ng1945

  • Decreasing incidence of lacunar vs other types of cerebral infarction in a Japanese population Reviewed International journal

    Kubo M, Kiyohara Y, Ninomiya T, Tanizaki Y, Yonemoto K, Doi Y, Hata J, Oishi Y, Shikata K, Iida M.

    Neurology   2006.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1212/01.wnl.0000216132.95207.b4

  • C-reactive protein and risk of first-ever ischemic and hemorrhagic stroke in a general Japanese population: the Hisayama Study Reviewed International journal

    Wakugawa Y, Kiyohara Y, Tanizaki Y, Kubo M, Ninomiya T, Hata J, Doi Y, Okubo K, Oishi Y, Shikata K, Yonemoto K, Maebuchi D, Ibayashi S, Iida M.

    Stroke   2006.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/01.STR.0000194958.88216.87

  • Chronic kidney disease and cardiovascular disease in a general Japanese population: the Hisayama Study Reviewed International journal

    Ninomiya T, Kiyohara Y, Kubo M, Tanizaki Y, Doi Y, Okubo K, Wakugawa Y, Hata J, Oishi Y, Shikata K, Yonemoto K, Hirakata H, Iida M.

    Kidney Int   2005.7

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    DOI: 10.1111/j.1523-1755.2005.00397.x

  • Hyperhomocysteinemia and the development of chronic kidney disease in a general population: the Hisayama Study Reviewed International journal

    Ninomiya T, Kiyohara Y, Kubo M, Tanizaki Y, Tanaka K, Okubo K, Nakamura H, Hata J, Oishi Y, Kato I, Hirakata H, Iida M.

    Am J Kidney Dis   2004.9

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Books

  • B.循環器病を引き起こす要因は何か B-1 脳卒中の危険因子 循環器病予防エビデンスブックVol.1 日本循環器病予防学会 三浦克之、大久保孝義(編)

    秦 淳、二宮 利治(Role:Joint author)

    2021.6 

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    Language:Japanese   Book type:Scholarly book

  • 第6章 知っておきたい血圧変動関連の臨床研究 20.ADVANCE研究サブ解析 血圧変動エビデンス&プラクティス 楽木宏美(編)

    秦 淳(Role:Joint author)

    先端医学社  2016.5 

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    Responsible for pages:p175   Language:Japanese   Book type:Scholarly book

  • 第1章 脳出血診療 3.脳出血の疫学 脳出血・くも膜下出血診療読本 豊田一則, 髙橋 淳(編)

    秦 淳, 清原 裕(Role:Joint author)

    中外医学社  2016.4 

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    Responsible for pages:p39-47   Language:Japanese   Book type:Scholarly book

  • 心房細動(AF)/心房細動による脳卒中の疫学 ファーマナビゲーター抗凝固療法編 山下武志, 是恒之宏, 矢坂正弘(編)

    古田 芳彦, 秦 淳, 清原 裕(Role:Joint author)

    メディカルレビュー社  2015.4 

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    Responsible for pages:pp92-101   Language:Japanese   Book type:Scholarly book

Presentations

  • 日本人地域住民におけるサルコペニアの疫学 Invited

    秦淳、二宮利治

    第44回日本肥満学会・第41回日本肥満症治療学会学術集会  2023.11 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:仙台市   Country:Japan  

  • 地域疫学研究を基盤とした脳梗塞発症のリスク予測:久山町研究 Invited

    秦淳、二宮利治

    第66回日本脳循環代謝学会学術集会  2023.11 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡市   Country:Japan  

  • 脳卒中予防の最前線:久山町研究の成績より Invited

    秦淳、二宮利治

    第59回日本循環器病予防学会学術集会  2023.6 

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    Event date: 2023.6

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:鹿児島   Country:Japan  

  • 地域型コホート研究からみた脳卒中の一次予防:久山町研究 Invited

    秦淳、二宮利治

    第48回日本脳卒中学会学術集会  2023.3 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • Conventional and novel risk factors for cardiovascular disease: the Hisayama Study Invited

    秦淳、二宮利治

    第87回日本循環器学会学術集会  2023.3 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 日本人を対象とした動脈硬化性疾患の新しい発症リスク予測モデル:久山町研究 Invited

    秦淳、本田貴紀、陳三妹、二宮利治

    第70回日本心臓病学会学術集会  2022.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • 脳卒中の危険因子とその予防 Invited

    秦淳、二宮利治

    第54回日本動脈硬化学会総会・学術集会  2022.7 

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    Event date: 2022.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:久留米   Country:Japan  

  • 久山町研究を基盤とした脳梗塞のゲノム疫学研究 Invited

    秦淳,二宮利治

    第57回日本循環器病予防学会学術集会  2021.6 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:ライブ配信   Country:Japan  

    脳梗塞は複数の環境要因と遺伝要因が組み合わさることにより発症すると考えられている。近年、世界各国で脳梗塞のゲノムワイド関連研究(GWAS)が実施され、エビデンスが蓄積されつつある。本講演では,福岡県久山町で継続中の疫学調査(久山町研究)が参加した脳梗塞のゲノム疫学研究の成果について概説する。
     まず、九州大学病院および近郊の医療機関を受診した脳梗塞患者1,112名(福岡脳卒中データベース研究 [FSR])を患者群,2002年に久山町の循環器健診を受診した心血管病の既往のない1,112名(久山町研究)を対照群として、脳梗塞のGWASを実施した.遺伝子領域を中心に抽出した52,608箇所の一塩基多型(SNP)を網羅的に解析したところ、PRKCH,AGTRL1,ARHGEF10を新規の脳梗塞関連遺伝子として見出した.さらに,1988年の久山町健診受診者1,642名を14年間追跡した成績を用いて,これらの遺伝子多型が新規脳梗塞の発症リスクと有意に関連することを明らかにした.
     続いて、岩手医科大学、理化学研究所および国内の主な疫学研究との共同研究において脳梗塞のポリジェニック・リスクスコア(PRS)を開発した。この研究では、バイオバンク・ジャパン、東北メディカルメガバンク、JPHC研究、J-MICC研究のGWASデータ(患者群13,214名、対照群26,470名)の統合研究により、357,367箇所のSNPsを用いたPRSを作成し、先述のFSRと久山町研究によるGWASサンプルを用いて、PRSの外的妥当性を検証した。さらに、2002年の久山町健診受診者3,038名を10年間追跡した成績を用いて、PRSが新規脳梗塞の発症リスクと関連することを確認した。
    今後、環境要因と遺伝要因の脳梗塞発症への相互的な影響が明らかになることにより、脳梗塞の個別的な予防に寄与することが期待される。

  • 脳卒中発症の危険因子としてのバイオマーカー:久山町研究 Invited

    秦淳,二宮利治

    第46回日本脳卒中学会学術集会  2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

    久山町研究は、福岡県久山町の地域一般住民を対象に1961年に創設された生活習慣病の疫学研究である。本研究では、高血圧、糖尿病、脂質異常症、喫煙習慣などの古典的な危険因子に関する評価に加えて、血清、尿などの生体試料を用いて測定した新規のバイオマーカーと循環器病発症の関係を検討している。
     動脈硬化の進展には血管壁の慢性炎症が関与していることはよく知られており、血清中の高感度C反応性蛋白(HS-CRP)は代表的な慢性炎症のバイオマーカーである。久山町研究では、1988年に久山町の循環器病健診を受診した40歳以上の住民2,589名を14年間追跡した成績を用いて血清HS-CRP値と脳卒中発症の関係を検討した。その結果、男性において血清HS-CRP値と脳梗塞発症リスクとの間に有意な正の関連があり、この関連は古典的な危険因子と独立していた。また、血清中のlipopolysaccharide結合蛋白(LBP)は肝臓で産生される急性期反応蛋白であり、ヒト腸内細菌叢などに生息しているグラム陰性桿菌の細胞壁構成因子であるlipopolysaccharideと複合体を形成することにより、マクロファージ活性化と慢性炎症誘導に関与することが知られている。そこで、2002年に久山町の循環器病健診を受診した40歳以上の住民2,568名を10年間追跡した成績を用いて血清LBP値と脳卒中発症の関係を検討したところ、血清LBP値の上昇に伴い脳卒中の発症リスク(多変量調整後)は有意に上昇した。
     本講演では、久山町研究のコホート研究の成績を用いて、炎症や心障害などに関するさまざまなバイオマーカーと脳卒中などの循環器疾患の発症との関連について概説する。

  • 日本人地域住民における動脈硬化性疾患とその危険因子の推移:久山町研究 Invited

    秦淳,二宮利治

    第52回日本動脈硬化学会総会・学術集会  2020.7 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:ライブ配信   Country:Japan  

    福岡県久山町では、1961年より循環器健診を受診した40歳以上の住民を対象に時代の異なる複数の前向きコホートを設定し,動脈硬化性疾患の危険因子に関する疫学調査(久山町研究)継続している.本研究では、脳卒中・虚血性心疾患の発症および死亡に関する追跡調査を行っているが、各コホートの受診率,追跡率は高く,死亡例の約75%において剖検を行い疾病や死因について詳細に評価している.したがって,本研究の成績は日本人地域住民における動脈硬化性疾患とその危険因子の実態を比較的正確に反映していると考えられる.
    本研究の成績によると,高血圧管理の向上や喫煙率の低下にともない,脳卒中および脳梗塞の年齢調整罹患率は1960年代から1970年代にかけて大きく低下した.しかし,1980年代以降はこれらの罹患率の低下の程度が鈍化した.一方,虚血性心疾患の罹患率には明らかな時代的変化はなかった.代謝性の危険因子である糖代謝異常(糖尿病・前糖尿病),高コレステロール血症,肥満の有病率が時代とともに増加したことにより,高血圧管理の向上や喫煙率の低下による動脈硬化性疾患発症の予防効果を相殺した可能性がある.さらに脳梗塞発症例をタイプ別に検討すると,高血圧を主因とするラクナ梗塞の占める割合は時代とともに低下し,代謝性危険因子を主因とするアテローム血栓性脳梗塞や,人口の高齢化を反映して心房細動などの心疾患を主因とする心原性脳塞栓症の占める割合が相対的に増加した.
    本講演では,約60年にわたる久山町研究の成績を用いて,動脈硬化性疾患とその危険因子の時代的推移に関する最近の知見を紹介する.

  • 高血圧と心血管病・認知症の疫学:久山町研究 Invited

    秦淳

    第35回日本脳神経血管内治療学会学術総会  2019.11 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:福岡   Country:Japan  

  • 糖尿病,脳梗塞,認知症のゲノム疫学研究 Invited

    秦淳,二宮利治

    第51回日本動脈硬化学会総会・学術集会  2019.7 

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    Event date: 2019.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • 福岡県久山町における認知症の疫学研究 Invited

    秦淳,小原知之,二宮利治

    第8回臨床高血圧フォーラム,第55回日本循環器病予防学会学術集会  2019.5 

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    Event date: 2019.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:久留米   Country:Japan  

  • 脳卒中の疫学 Invited

    秦淳

    第44回日本脳卒中学会学術集会  2019.3 

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    Event date: 2019.3 - 2019.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • 心血管病の新しい危険因子としてのバイオマーカー: 久山町研究 Invited

    秦淳,二宮利治

    第64回日本心臓病学会学術集会  2016.9 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 性別・年齢階級別にみた脳卒中とその危険因子の疫学 Invited

    秦淳

    第42回日本脳卒中学会学術総会  2017.3 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • 福岡県久山町における認知症の疫学研究コホート研究から得られた認知症に関する最近の知見

    秦淳,小原知之,二宮利治

    第55回日本循環器病予防学会学術集会  2019.5 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:久留米   Country:Japan  

  • 食環境と健康長寿のフロンティア. 生活習慣病のオーダーメイド予防:久山町研究. Invited

    秦淳,久保充明,清原裕

    日本栄養・食糧学会九州・沖縄支部. 佐賀大学産学官連携推進機構および佐賀大学医食同源プロジェクト合同公開講座  2007.4 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:佐賀   Country:Japan  

  • 久山町研究を基盤とした脳梗塞のゲノムワイド関連遺伝子研究 Invited

    秦淳,清原裕

    第63回日本臨床眼科学会・第10回眼科DNAチップ研究会  2009.10 

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    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:福岡   Country:Japan  

  • 久山町研究を基盤とした脳梗塞のゲノムワイド関連研究 Invited

    秦淳,久保充明,清原裕

    第80回日本衛生学会学術総会  2010.5 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:仙台   Country:Japan  

  • 一般住民における心房細動の特徴と予後 Invited

    秦淳,後藤聖司,福原正代,清原裕

    第37回日本脳卒中学会総会  2012.4 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • Stroke epidemiology in Japan: the Hisayama Study Invited International conference

    Hata J,Kiyohara Y

    2nd Asia Pacific Stroke Conference  2012.9 

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    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • Diabetes mellitus as a risk factor for cancer: the Hisayama Study Invited

    Hata J,Kiyohara Y

    第72回日本癌学会学術総会  2013.10 

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    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • 脳卒中のバイオマーカー:久山町研究 Invited

    秦淳,清原裕

    第39回日本脳卒中学会総会  2014.3 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  • 心血管病と認知症の疫学:久山町研究 Invited

    秦淳,清原裕

    第56回日本老年医学会学術集会  2014.6 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 日本人における心血管病危険因子の時代的変化と特徴:久山町研究 Invited

    秦淳,清原裕

    第17回日本栓子検出と治療学会  2014.10 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 糖代謝異常・脂質異常症と脳卒中の疫学:久山町研究 Invited

    秦淳,清原裕

    第40回日本脳卒中学会総会  2015.3 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:広島   Country:Japan  

  • 動脈硬化性疾患の新しい危険因子:久山町研究から Invited

    秦淳,清原裕

    第47回日本動脈硬化学会総会・学術集会  2015.7 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:仙台   Country:Japan  

  • 高血圧と心臓合併症の疫学:久山町研究を中心に Invited

    秦淳,清原裕,二宮利治

    第38回日本高血圧学会総会  2015.10 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:松山   Country:Japan  

  • Risk factors for carotid atherosclerosis: the Hisayama Study. Invited

    Hata J,Ninomiya T.

    第49回日本動脈硬化学会総会・学術集会  2017.7 

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    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:広島   Country:Japan  

  • 網羅的ゲノム解析による脳梗塞関連遺伝子の探索 Invited

    秦淳

    第43回日本脳卒中学会学術総会  2018.3 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 血清angiopoietin-like protein 2 (ANGPTL2)濃度と死因別死亡の関連:久山町研究

    秦淳、坂田智子、古田芳彦、大石絵美、本田貴紀、柴田舞欧、北園孝成、尾池雄一、二宮利治

    第60回日本循環器病予防学会学術集会  2024.5 

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    Event date: 2024.5

    Language:Japanese  

    Venue:東京都   Country:Japan  

  • 日本人地域住民における心房細動発症のリスク予測モデルの開発:久山町研究

    秦淳,坂田智子,永田拓也,平川洋一郎,大石絵美,本田貴紀,吉田大悟,北園孝成,二宮利治

    第55回日本循環器病予防学会学術集会  2019.5 

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    Event date: 2019.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:久留米   Country:Japan  

  • βアラニン血中濃度と認知症発症の関連:久山町研究

    秦淳,小原知之,片倉喜範,清水邦義,山下俊太郎,吉田大悟,本田貴紀,平川洋一郎,柴田舞欧,坂田智子,北園孝成,久原哲,二宮利治

    第25回日本未病システム学会学術総会  2018.10 

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    Event date: 2018.10 - 2019.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

    【背景】わが国では認知症とくにアルツハイマー型認知症(AD)の有病率が時代とともに増加し,その予防対策は医療的・社会的に重要な課題となっている.近年の疫学研究により,栄養・食事性因子と認知症発症の関連が検討されるようになり,その発症予防に有用な機能性食品の開発も進められている.そのなかで,鶏肉に多く含有するイミダゾールジペプチドとして知られるカルノシン・アンセリンの摂取が抗酸化作用・抗糖化作用・抗炎症作用を介して認知機能障害に予防的に作用することが,健常者を対象とした介入研究および動物実験によって明らかとされつつある.しかし,地域住民を対象とした疫学研究によってこれらのジペプチドと認知症の発症リスクとの関連について検討した報告は存在しない.
    【目的】福岡県久山町の地域高齢者を対象とした追跡調査の成績を用いて,カルノシン・アンセリンの分解産物であるβアラニンの血中濃度と認知症の発症リスクとの関連について検討した.
    【方法】2007年に久山町の循環器健診を受診した認知症のない60~79歳の男女1,475名を対象とした.健診時に採取した血清を用いてβアラニンの血中濃度を液体クロマトグラフ質量分析法により測定し,その4分位を用いてQ1群0.29-0.76 μmol/L,Q2群0.77-0.96 μmol/L,Q3群0.97-1.22 μmol/L,Q4群1.23-8.34 μmol/Lに分類した.この集団を2012年まで追跡し,βアラニン血中濃度と認知症およびその主要病型(AD,血管性認知症[VaD])の発症リスクとの関連をKaplan-Meier法およびCox比例ハザードモデルを用いて検討した.
    【結果】5.3年間(中央値)の追跡期間中に117名が認知症を発症した(AD 77名,VaD 31名).5年間の全認知症の累積罹患率は,βアラニン血中濃度が高くなるとともに有意に低下した(Q1群9.9%,Q2群8.6%,Q3群4.9%,Q4群4.7%).同様の関連はADの累積罹患率についても認められた(Q1群6.8%,Q2群5.5%,Q3群3.5%,Q4群2.5%).一方,VaDの累積罹患率との間には明らかな関連を認めなかった(Q1群1.8%,Q2群2.4%,Q3群1.5%,Q4群2.0%).さらに,性,年齢,教育歴,収縮期血圧,降圧薬使用,糖尿病,血清総コレステロール値,BMI,脳卒中既往,喫煙,飲酒,運動習慣,総エネルギー摂取量で調整した多変量解析においても,βアラニン血中濃度の上昇に伴い,全認知症およびAD発症のハザード比[95%信頼区間]は有意に低下した(全認知症:Q1群1.00 [基準], Q2群0.73 [0.45-1.18],Q3群0.50 [0.28-0.89],Q4群0.50 [0.27-0.92],傾向性p=0.01.AD:Q1群1.00 [基準], Q2群0.78 [0.44-1.38],Q3群0.53 [0.26-1.06] ,Q4群0.53 [0.25-1.10],傾向性p=0.04).
    【結論】日本人の地域高齢者において,βアラニン血中濃度の高値は認知症とくにADの有意な独立した保護因子であった.鶏肉などカルノシン・アンセリンあるいはβアラニンを含有する食事をより多く摂取することにより,認知症の予防につながることが示唆される.

  • 地域住民における白衣高血圧,仮面高血圧とアルブミン尿症の関連:久山町研究 Invited

    秦淳,福原正代,坂田智子,有馬久富,平川洋一郎,米本孝二,向井直子,北園孝成,清原裕,二宮利治

    第41回日本高血圧学会総会  2018.9 

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    Event date: 2018.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:旭川   Country:Japan  

    【背景と目的】近年,診察室血圧に加えて家庭血圧の測定が推奨されるようになり,白衣高血圧(WCHT)や仮面高血圧(MHT)の臨床的意義が注目されている。しかし,これらの血圧異常が慢性腎臓病(CKD)およびその構成因子(アルブミン尿症,腎機能低下)におよぼす影響について検討した疫学調査の報告は少ない.そこで,福岡県久山町の地域住民における疫学調査の成績を用いてこれらの関連について検討した.
    【対象と方法】2007年に久山町循環器健診を受診し,家庭血圧測定を行った40歳以上の住民2974名を対象とした.家庭血圧は早朝起床後に座位で連続3回28日間測定,診察室血圧は健診会場にて座位で連続3回測定し,それぞれの平均値を用いて,対象者を正常血圧(NT)群(家庭血圧<135/85 mmHgかつ診察室血圧<140/90 mmHg: n=1388),WCHT群(家庭血圧<135/85 mmHgかつ診察室血圧≧140/90 mmHg: n=209),MHT群(家庭血圧≧135/85 mmHgかつ診察室血圧<140/90 mmHg: n=642),持続性高血圧(SHT)群(家庭血圧≧135/85 mmHgかつ診察室血圧≧140/90 mmHg: n=735)の4群に分類した.CKDはアルブミン尿症(尿中アルブミン/クレアチニン比≧30 mg/g)または腎機能低下(推算糸球体濾過量<60 ml/分/1.73 m2)のいずれかと定義した.血圧分類とCKDおよびその構成因子との関連は,ロジスティック回帰を用いて検討した.
    【結果】NT群を基準としたCKDの性年齢調整後のオッズ比(95%信頼区間)はWCHT群2.05(1.49-2.81),MHT群1.53(1.23-1.90),SHT群3.34(2.71-4.11)であり,いずれのタイプの高血圧においてもCKDを有する可能性が有意に高かった.さらに,主な心血管危険因子の影響を多変量調整したところ,WCHT群とSHT群において有意な関連を認めた(オッズ比[95%信頼区間]:WCHT群1.64[1.18-2.28],MHT群1.20[0.95-1.52],SHT群2.62[2.10-3.27]).CKDの構成因子別に検討したところ,WCHT,MHT,SHTはいずれもアルブミン尿症と有意に関連した(多変量調整オッズ比[95%信頼区間]:WCHT群1.77[1.22-2.57],MHT群1.74[1.34-2.26],SHT群3.93[3.08-5.01]).しかし,これらの血圧分類と腎機能低下との間には明らかな関連はなかった.
    【結論】地域住民を対象とした横断研究により,SHT者のみならずWCHT者やMHT者においてもNT者と比べてCKD、特にアルブミン尿症を有するリスクが高くなることが示唆された.今後は前向き追跡研究による検証が必要である.

  • 慢性期循環器疾患患者における死亡リスク予測モデルの開発:バイオバンク・ジャパン

    秦淳,永井亜貴子,平田真,鎌谷洋一郎,玉腰暁子,山縣然太朗,武藤香織,松田浩一,久保充明,清原裕,二宮利治

    第27回日本疫学会学術総会  2017.1 

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    Event date: 2017.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:甲府   Country:Japan  

  • 経口腔エコーが有用であった内頚動脈狭窄症の一例

    秦 淳,岸川和裕,永富葉子,荒川修治,鴨打正浩,岡田 靖,井上 亨,安森弘太郎

    第148回日本神経学会九州地方会  1999.12 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大分   Country:Japan  

  • 肝細胞癌に対する皮下埋め込み型動注システム留置中に発症した脳梗塞4症例の検討

    秦 淳,竹迫仁則,中村 宏,古賀政利,六倉和生,井上 剛,朔 義亮

    第151回日本神経学会九州地方会  2000.9 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:佐賀   Country:Japan  

  • 肝悪性腫瘍に対する皮下植え込み型動注システムに発症した脳梗塞症例の検討

    秦 淳,竹迫仁則,中村 宏,井上 剛,古賀政利,六倉和生,朔 義亮,井林雪郎

    第26回日本脳卒中学会総会  2001.3 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • 地域住民における脳卒中の病型別再発率の検討:久山町研究

    秦淳,谷崎弓裕,清原裕,加藤功,久保充明,田中圭一,大久保賢,中村秀敏,尾石義謙,井林雪郎,飯田三雄

    第28回日本脳卒中学会総会  2003.3 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 純粋型レビー小体型痴呆の1剖検例

    秦淳,谷崎弓裕,脇坂義信,清原裕,加藤功,久保充明,大久保賢,田中圭一,中村秀敏,尾石義謙,飯田三雄

    第13回日本老年医学会九州地方会  2003.3 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:熊本   Country:Japan  

  • 一般住民におけるメタボリックシンドロームがタイプ別脳梗塞の発症に及ぼす影響:久山町研究

    秦淳,谷崎弓裕,土井康文,二宮利治,有馬久富,今村剛,米本孝二,清原裕,井林雪郎,飯田三雄

    第18回日本疫学会学術総会  2008.1 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • メタボリックシンドロームは全ての脳梗塞タイプの有意な危険因子である:久山町研究

    秦淳,谷崎弓裕,土井康文,二宮利治,有馬久富,今村剛,米本孝二,井林雪郎,飯田三雄,清原裕

    第33回日本脳卒中学会総会  2008.3 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • AGTRL1遺伝子の一塩基多型(SNP)が脳梗塞の発症に及ぼす影響

    秦淳,久保充明,二宮利治,米本孝二,松下知永,北園孝成,井林雪郎,飯田三雄,中村祐輔,清原裕

    第33回日本脳卒中学会総会  2008.3 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • 新規脳梗塞関連遺伝子AGTRL1の同定と機能解析 Invited

    秦淳,久保充明,北園孝成,飯田三雄,中村祐輔,清原裕

    第9回日本分子脳神経外科学会  2008.8 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:京都   Country:Japan  

  • 一般住民における喫煙が脳卒中と虚血性心疾患の発症に及ぼす影響:久山町研究

    秦淳,土井康文,谷崎弓裕,今村剛,福原正代,米本孝二,北園孝成,飯田三雄,清原裕

    第34回日本脳卒中学会総会  2009.3 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:松江   Country:Japan  

  • 地域住民における喫煙と虚血性心疾患・脳卒中発症との関連:久山町研究

    秦淳,土井康文,谷崎弓裕,今村剛,福原正代,米本孝二,北園孝成,飯田三雄,清原裕

    第45回日本循環器病予防学会・日本循環器管理研究協議会総会  2009.6 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • 急性期脳出血に対する積極的降圧療法がmidline shiftと水頭症の進行に及ぼす影響:INTERACT試験

    秦淳,Fullard K,Delcourt C,HeeleyE,有馬久富,Anderson C

    第36回日本脳卒中学会総会  2011.3 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 2型糖尿病患者における腎機能増悪予測モデル:ADVANCE試験

    秦淳,Jardin M,有馬久富,二宮利治,Zongas S,Perkovic V,Anderson C,Woodward M,Cass A,Patel A,Chalmers J

    第34回日本高血圧学会総会  2011.10 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:宇都宮   Country:Japan  

  • 一般住民における脳卒中、虚血性心疾患罹患率とその危険因子の50年にわたる時代的推移:久山町研究

    秦淳,二宮利治,平川洋一郎,永田雅治,向井直子,後藤聖司,福原正代,鴨打正浩,北園孝成,清原裕

    第38回日本脳卒中学会総会  2013.3 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • Angiopoietin-like protein 2 (ANGPTL2) and the risk of cardiovascular disease in a general Japanese population: the Hisayama Study

    Hata J,Ninomiya T,Fukuhara M,Nagata M,Kitazono T,Oike Y,Kiyohara Y

    第79回日本循環器学会学術集会  2015.4 

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    Language:English   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

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MISC

  • Epidemiology of stroke in a general Japanese population: the Hisayama Study

    Hata J, Ninomiya T

    J Atheroscler Thromb, 2023; 30: 710-719   2023.6

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: http://doi.org/10.5551/jat.RV22004

  • 動脈硬化性疾患(脳梗塞を含む)の疫学

    秦淳

    medicina   2024.7

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 脳卒中疫学:最近の傾向

    秦淳、二宮利治

    日本臨牀   2023.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 冠動脈疾患の疫学と危険因子

    秦淳、二宮利治

    循環器内科   2022.10

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 脳卒中の疫学

    秦淳、二宮利治

    臨牀と研究   2021.12

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 脳梗塞のゲノム疫学研究. Reviewed

    秦 淳、二宮利治

    医学のあゆみ   2021.7

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 脳梗塞のゲノム疫学:久山町研究

    秦 淳、二宮 利治

    Precision Medicine   2021.2

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 脳卒中の疫学

    秦 淳,二宮 利治

    日本臨牀   2019.6

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  • 脂質異常症と動脈硬化性疾患の疫学研究

    秦 淳,二宮 利治

    CARDIAC PRACTICE   2018.6

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 地域住民における白衣高血圧,仮面高血圧とアルブミン尿症の関連:久山町研究

    秦 淳

    血圧   2018.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 地域住民を対象とした疫学研究

    秦 淳, 小原知之、二宮利治

    日本医師会雑誌 生涯教育シリーズ   2017.6

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 糖代謝異常・脂質異常症と脳卒中の疫学:久山町研究

    秦 淳, 清原 裕

    脳卒中   2016.11

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • ヘマトクリットと心血管病発症の関係:久山町研究

    後藤 聖司, 秦 淳, 清原 裕

    血圧   2016.4

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  • 脳卒中のバイオマーカー:久山町研究

    秦 淳,清原 裕

    脳卒中   2015.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 糖尿病と認知症の疫学

    秦 淳,清原 裕

    糖尿病診療マスター   2015.8

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 動脈硬化の診断と治療の現況と展望.久山町研究から

    大石絵美,秦 淳,清原 裕

    月刊カレントテラピー   2015.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

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Industrial property rights

Patent   Number of applications: 1   Number of registrations: 0
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • Japanese Society of Public Health

  • Japan Epidemiological Association

  • Japan Mibyou Association

  • Japanese Society of Neurology

  • Japanese Society of Hypertension

  • Japanese Society of Cardiovascular Disease Prevention

  • Japanese Circulation Society

  • Japan Stroke Society

  • Japanese Society of Internal Medicine

  • Society for Clinical Epidemiology

  • Japan Geriatrics Society

  • American Heart Association

  • Japan Atherosclerosis Society

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Committee Memberships

  • 日本未病学会   Councilor   Domestic

    2021.11 - Present   

  • 日本脳卒中学会   Councilor   Domestic

    2018.3 - Present   

  • 日本疫学会   代議員   Domestic

    2017.6 - 2025.6   

  • 日本循環器病予防学会   Councilor   Domestic

    2013.4 - Present   

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2024

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:7

  • 座長

    第59回日本循環器病予防学会学術集会  ( Japan ) 2023.6

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    Type:Competition, symposium, etc. 

  • Hypertension Resaearch

    2023.3 - Present

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    Type:Academic society, research group, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2023

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:20

  • Screening of academic papers

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:20

    Number of peer-reviewed articles in Japanese journals:1

  • 座長

    第46回日本脳卒中学会学術集会  ( Japan ) 2021.3 - 2021.4

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:9

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:20

  • 実行委員

    日本臨床疫学会第3回年次学術大会  ( Japan ) 2019.9

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2019

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:27

  • Screening of academic papers

    Role(s): Peer review

    2018

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:23

  • 脳卒中

    Role(s): Peer review

    2017.6 - Present

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    Type:Academic society, research group, etc. 

  • 座長(Chairmanship)

    第27回日本老年医学会九州地方会  ( Japan ) 2017.3

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2017

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:21

    Number of peer-reviewed articles in Japanese journals:1

  • 副実行委員長

    第23回日本未病システム学会学術総会  ( Japan ) 2016.11 - 2017.11

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    Type:Competition, symposium, etc. 

  • Journal of Stroke and Cerebrovascular Diseases International contribution

    Role(s): Peer review

    2015.10 - 2019.12

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    Type:Academic society, research group, etc. 

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Research Projects

  • 心電図所見を用いた心房細動・循環器疾患・認知症の発症予測:久山町研究

    2023.4 - 2026.3

    日本 

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    Authorship:Principal investigator 

  • 心電図所見を用いた心房細動・循環器疾患・認知症の発症予測:久山町研究

    Grant number:23K09692  2023 - 2025

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 大規模前向きコホートデータを基盤とした認知症のゲノム・脳画像研究

    2021.4 - 2026.3

    日本 

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    Authorship:Coinvestigator(s) 

  • 腸内細菌叢と生活習慣病・認知症・うつ病発症に関する地域コホート研究:久山町研究

    2021.4 - 2024.3

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    Authorship:Coinvestigator(s) 

  • 大規模前向きコホートデータを基盤とした認知症のゲノム・脳画像研究

    2021 - 2025

    国立研究開発法人日本医療研究開発機構・認知症研究開発事業

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 腸内細菌叢と生活習慣病・認知症・うつ病発症に関する地域コホート研究:久山町研究

    Grant number:21H03200  2021 - 2023

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 地域住民における心房細動発症のバイオマーカーと遺伝要因:久山町研究

    2020.4 - 2023.3

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    Authorship:Principal investigator 

  • 地域住民における心房細動発症のバイオマーカーと遺伝要因:久山町研究

    Grant number:20K10503  2020 - 2022

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 地域高齢住民におけるサルコペニアと認知症発症との関連:久山町研究

    2017.4 - 2020.3

    九州大学(日本) 

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    Authorship:Coinvestigator(s) 

    We investigate the association of sarcopenia with dementia using the follow-up data of the residents of Hisayama, Fukuoka aged 65 years or over.

  • 地域高齢住民におけるサルコペニアと認知症発症との関連:久山町研究

    Grant number:17K01853  2017 - 2019

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 健康長寿社会の実現を目指した大規模認知症コホート研究

    2016.4 - 2021.3

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    Authorship:Coinvestigator(s) 

  • 久山町高齢者におけるMRIを基盤にした認知症・うつ病発症の前向きコホート研究

    2016.4 - 2019.3

    九州大学 

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    Authorship:Coinvestigator(s) 

  • 健康長寿社会の実現を目指した大規模認知症コホート研究

    2016 - 2020

    国立研究開発法人日本医療研究開発機構・認知症研究開発事業

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 久山町高齢者におけるMRIを基盤にした認知症・うつ病発症の前向きコホート研究

    Grant number:16H02644  2016 - 2018

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • NCD-RisC International coauthorship

    2015.12

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

    世界の観察研究を統合したメタ解析

  • MEGASTROKE International coauthorship

    2015.11

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

    世界の脳卒中のゲノムワイド関連解析研究(GWAS)を統合したメタ解析

  • 久山町一般住民におけるむずむず脚症候群と脳心血管病についての検討

    2015.4 - 2018.3

    九州大学 

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    Authorship:Coinvestigator(s) 

  • 健康長寿社会の実現を目指した大規模認知症コホート研究の創設

    2015.4 - 2016.3

    九州大学 

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    Authorship:Coinvestigator(s) 

  • 久山町一般住民におけるむずむず脚症候群と脳心血管病についての検討

    Grant number:15K08737  2015 - 2017

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 健康長寿社会の実現を目指した大規模認知症コホート研究の創設

    2015

    国立研究開発法人日本医療研究開発機構・認知症研究開発事業

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 地域住民における余暇時の運動習慣および運動量が健康寿命に与える影響:久山町研究

    2014.4 - 2017.3

    九州大学 

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    Authorship:Coinvestigator(s) 

  • 日本人地域住民における心房細動の実態と危険因子に関する研究:久山町研究

    2014.4 - 2017.3

    九州大学 

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    Authorship:Principal investigator 

  • 日本人地域住民における心房細動の実態と危険因子に関する研究:久山町研究

    Grant number:26460748  2014 - 2016

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 地域住民における余暇時の運動習慣および運動量が健康寿命に与える影響:久山町研究

    Grant number:26350895  2014 - 2016

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 久山町高齢者におけるMRIを基盤にした脳血管障害,認知症,うつ病の疫学研究

    2013.4 - 2016.3

    九州大学 

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    Authorship:Coinvestigator(s) 

  • 久山町高齢者におけるMRI を基盤にした脳血管障害,認知症,うつ病の疫学研究

    Grant number:25253048  2013 - 2015

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

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Educational Activities

  • Lecture and education at the Department of Health Care Administration and Management.
    Lecture of public health at the Faculty of Medicine.

Class subject

  • 医療保障法

    2024.10 - 2025.3   Second semester

  • 疾病管理学

    2024.10 - 2025.3   Second semester

  • 衛生・公衆衛生学

    2024.4 - 2024.9   First semester

  • 衛生・公衆衛生学

    2024.4 - 2024.9   First semester

  • 疫学

    2024.4 - 2024.9   First semester

  • 内科学

    2024.4 - 2024.9   First semester

  • 臨床疫学

    2023.10 - 2024.3   Second semester

  • 衛生・公衆衛生学

    2023.4 - 2024.3   Full year

  • 衛生・公衆衛生学

    2022.10 - 2023.3   Second semester

  • 衛生・公衆衛生学

    2022.4 - 2022.9   First semester

  • 衛生・公衆衛生学

    2021.10 - 2022.3   Second semester

  • 衛生・公衆衛生学

    2021.4 - 2021.9   First semester

  • 衛生・公衆衛生学

    2020.10 - 2021.3   Second semester

  • 衛生・公衆衛生学

    2020.4 - 2020.9   First semester

  • 衛生・公衆衛生学

    2019.10 - 2020.3   Second semester

  • 衛生・公衆衛生学

    2019.4 - 2019.9   First semester

  • 衛生・公衆衛生学

    2018.10 - 2019.3   Second semester

  • 衛生・公衆衛生学

    2018.4 - 2018.9   First semester

  • 衛生・公衆衛生学

    2017.10 - 2018.3   Second semester

  • 衛生・公衆衛生学

    2017.4 - 2017.9   First semester

  • 循環器

    2016.10 - 2017.3   Second semester

  • 医学実習

    2016.10 - 2017.3   Second semester

  • 衛生学

    2016.10 - 2017.3   Second semester

  • 衛生学

    2016.10 - 2017.3   Second semester

  • アカデミックフロンティア

    2016.10 - 2017.3   Second semester

  • 医学実習

    2016.4 - 2016.9   First semester

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Outline of Social Contribution and International Cooperation activities

  • 福岡県久山町における生活習慣病予防健診その他の健康・保健事業への医師・公衆衛生学専門家としての協力

Social Activities

  • ストップ!脳卒中~未破裂脳動脈瘤の管理と認知症予防~

    日本脳卒中協会福岡県支部  福岡市  2017.5

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    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 市民公開セミナー ストップ!脳卒中 脈をとり、圧を測り、脳を守る 「圧の測り方、高血圧と脳梗塞予防」

    日本脳卒中協会福岡県支部,ブリストルマイヤーズ株式会社  福岡市  2015.5

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    Audience:General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

Media Coverage

  • 糖尿病 脳の萎縮進む Newspaper, magazine

    朝日新聞  2016.6

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    糖尿病 脳の萎縮進む

  • 再発しやすい脳卒中 Newspaper, magazine

    共同通信社加盟各紙  2015.6

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    再発しやすい脳卒中

Activities contributing to policy formation, academic promotion, etc.

  • 2023.5 - 2024.3   福岡市保健医療局総務企画部保険医療課

    福岡市特定健診・特定保健指導に関する連絡会議委員

  • 2023.4 - 2025.3   福岡県糟屋郡久山町健康課

    久山町生活習慣病予防対策推進協議会

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Clinical Internal Medicine / Stroke Science

Clinician qualification

  • Preceptor

    社会医学系専門医協会

  • Specialist

    社会医学系専門医協会

  • 上席疫学専門家

    日本疫学会

  • Specialist

    The Japan Stroke Society

  • Certifying physician

    The Japanese Society of Internal Medicine(JSIM)

  • Specialist

    The Japanese Society of Internal Medicine(JSIM)

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Year of medical license acquisition

  • 1998