Updated on 2025/06/30

Information

 

写真a

 
FURUKAWA KENTARO
 
Organization
Faculty of Medical Sciences Department of Basic Medicine Assistant Professor
School of Medicine Department of Medicine(Concurrent)
Title
Assistant Professor
Contact information
メールアドレス
Tel
0926426089
Profile
I am studying mitochondrial autophagy (mitophagy) using yeast as a model organism.

Research Areas

  • Life Science / Cell biology

Degree

  • Doctor of Agriculture

Research History

  • Niigata University 大学院医歯学総合研究科 客員研究員 

    2024.4 - Present

  • Kyushu University 大学院医学研究院 Assistant Professor 

    2024.4 - Present

  • Niigata University 大学院医歯学総合研究科 Specially Appointed Lecturer 

    2023.4 - 2024.3

  • Niigata University 大学院医歯学総合研究科 Specially Appointed Assistant Professor 

    2015.2 - 2023.3

  • ヨーテボリ大学  上級研究員 

    2009.11 - 2014.12

  • ヨーテボリ大学  ポスドク研究員 

    2006.5 - 2009.10

  • Tohoku University 大学院農学研究科 日本学術振興会特別研究員 (PD) 

    2005.4 - 2006.3

  • Tohoku University 大学院農学研究科 日本学術振興会特別研究員 (DC2) 

    2004.4 - 2005.3

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Education

  • Tohoku University   大学院農学研究科   応用生命科学専攻・博士課程

    2002.4 - 2005.3

  • Tohoku University   大学院農学研究科   応用生命科学専攻・修士課程

    2000.4 - 2002.3

  • Tohoku University   農学部  

    1996.4 - 2000.3

Research Interests・Research Keywords

  • Research theme: Molecular mechanisms of mitochondrial autophagy (mitophagy) and mitochondrial fission

    Keyword: mitochondria・autophagy・mitophagy・mitochondrial fission・yeast

    Research period: 2015.2

Awards

  • 令和4年度新潟大学優秀論文表彰

    2022.11   新潟大学  

  • 令和3年度新潟大学優秀論文表彰

    2021.12   新潟大学  

  • 令和2年度新潟大学優秀論文表彰

    2021.1   新潟大学  

  • 若手奨励賞

    2015.10   日本農芸化学会・東北支部  

Papers

  • Atg44/Mdi1/mitofissin facilitates Dnm1-mediated mitochondrial fission

    Furukawa, K; Hayatsu, M; Okuyama, K; Fukuda, T; Yamashita, SI; Inoue, K; Shibata, S; Kanki, T

    AUTOPHAGY   20 ( 10 )   2314 - 2322   2024.10   ISSN:1554-8627 eISSN:1554-8635

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    Language:English   Publisher:Autophagy  

    Mitochondria undergo fission and fusion, and their coordinated balance is crucial for maintaining mitochondrial homeostasis. In yeast, the dynamin-related protein Dnm1 is a mitochondrial fission factor acting from outside the mitochondria. We recently reported the mitochondrial intermembrane space protein Atg44/mitofissin/Mdi1/Mco8 as a novel fission factor, but the relationship between Atg44 and Dnm1 remains elusive. Here, we show that Atg44 is required to complete Dnm1-mediated mitochondrial fission under homeostatic conditions. Atg44-deficient cells often exhibit enlarged mitochondria with accumulated Dnm1 and rosary-like mitochondria with Dnm1 foci at constriction sites. These mitochondrial constriction sites retain the continuity of both the outer and inner membranes within an extremely confined space, indicating that Dnm1 is unable to complete mitochondrial fission without Atg44. Moreover, accumulated Atg44 proteins are observed at mitochondrial constriction sites. These findings suggest that Atg44 and Dnm1 cooperatively execute mitochondrial fission from inside and outside the mitochondria, respectively. Abbreviation: ATG: autophagy related; CLEM: correlative light and electron microscopy; EM: electron microscopy; ER: endoplasmic reticulum; ERMES: endoplasmic reticulum-mitochondria encounter structure; GA: glutaraldehyde; GFP: green fluorescent protein; GTP: guanosine triphosphate: IMM: inner mitochondrial membrane; IMS: intermembrane space; OMM: outer mitochondrial membrane; PB: phosphate buffer; PBS: phosphate-buffered saline; PFA: paraformaldehyde; RFP: red fluorescent protein; WT: wild type.

    DOI: 10.1080/15548627.2024.2360345

    Web of Science

    Scopus

    PubMed

  • 酵母のatg変異体における非選択的と選択的なオートファジーおよびAtg8結合系が欠損した場合のオートファジー活性の特徴の包括的な分析(Comprehensive analysis of non-selective and selective autophagy in yeast atg mutants and characterization of autophagic activity in the absence of the Atg8 conjugation system)

    Ginevskaia Tamara, Innokentev Aleksei, Furukawa Kentaro, Fukuda Tomoyuki, Hayatsu Manabu, Yamashita Shun-ichi, Inoue Keiichi, Shibata Shinsuke, Kanki Tomotake

    The Journal of Biochemistry   176 ( 3 )   217 - 227   2024.9   ISSN:0021-924X

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    Language:English   Publisher:(公社)日本生化学会  

    出芽酵母Saccharomyces cerevisiaeのatg変異体における非選択的オートファジー活性、細胞質から液胞への標的化(Cvt)経路、マイトファジー、小胞体(ER)ファジー、およびペクソファジーについて定量化を行った。オートファジーにとって必須と考えられているコアオートファジー遺伝子のうち、atg13の変異株と2種のユビキチン様結合システム関連遺伝子の変異株は常在性オートファジーの機能を保持していた。特に、Atg8ユビキチン様結合システム(Atg8システム)の変異株は非選択的オートファジー、Cvt経路、およびペクソファジーの活性を強く保持していたが、マイトファジーとERファジー活性は認められなかった。Atg8システムの変異株はオートファジックボディに類似した液胞内小胞を保有していたが、それらの大きさや頻度は減少していた。以上より、膜による隔離とオートファジックカーゴの液胞による送達はAtg8システムを欠損していても起こりうると考えられた。

  • Comprehensive analysis of non-selective and selective autophagy in yeast atg mutants and characterization of autophagic activity in the absence of the Atg8 conjugation system

    Ginevskaia, T; Innokentev, A; Furukawa, K; Fukuda, T; Hayatsu, M; Yamashita, S; Inoue, K; Shibata, S; Kanki, T

    JOURNAL OF BIOCHEMISTRY   176 ( 3 )   217 - 227   2024.6   ISSN:0021-924X eISSN:1756-2651

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    Language:English   Publisher:Journal of Biochemistry  

    Most autophagy-related genes, or ATG genes, have been identified through studies using budding yeast. Although the functions of the ATG genes are well understood, the contributions of individual genes to non-selective and various types of selective autophagy remain to be fully elucidated. In this study, we quantified the activity of non-selective autophagy, the cytoplasm-to-vacuole targeting (Cvt) pathway, mitophagy, endoplasmic reticulum (ER)-phagy and pexophagy in all Saccharomyces cerevisiae atg mutants. Among the mutants of the core autophagy genes considered essential for autophagy, the atg13 mutant and mutants of the genes involved in the two ubiquitin-like conjugation systems retained residual autophagic functionality. In particular, mutants of the Atg8 ubiquitin-like conjugation system (the Atg8 system) exhibited substantial levels of non-selective autophagy, the Cvt pathway and pexophagy, although mitophagy and ER-phagy were undetectable. Atg8-system mutants also displayed intravacuolar vesicles resembling autophagic bodies, albeit at significantly reduced size and frequency. Thus, our data suggest that membranous sequestration and vacuolar delivery of autophagic cargo can occur in the absence of the Atg8 system. Alongside these findings, the comprehensive analysis conducted here provides valuable datasets for future autophagy research.

    DOI: 10.1093/jb/mvae042

    Web of Science

    Scopus

    PubMed

  • Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species. Reviewed International journal

    Yamashita SI, Sugiura Y, Matsuoka Y, Maeda R, Inoue K, Furukawa K, Fukuda T, Chan DC, Kanki T.

    Cell Death Differ   2024.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41418-024-01280-y.

  • The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy. Reviewed International journal

    Fukuda T, Furukawa K, Maruyama T, Yamashita SI, Noshiro D, Song C, Ogasawara Y, Okuyama K, Alam JM, Hayatsu M, Saigusa T, Inoue K, Ikeda K, Takai A, Chen L, Lahiri V, Okada Y, Shibata S, Murata K, Klionsky DJ, Noda NN, Kanki T.

    Mol Cell   2023.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.molcel.2023.04.022.

  • Hva22, a REEP family protein in fission yeast, promotes reticulophagy in collaboration with a receptor protein. Reviewed International journal

    Fukuda T, Saigusa T, Furukawa K, Inoue K, Yamashita SI, Kanki T.

    Autophagy   2023.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/15548627.2023.2214029.

  • Downregulation of the ypdA gene encoding an intermediate of His-Asp phosphorelay signaling in Aspergillus nidulans induces the same cellular effects as the phenylpyrrole fungicide fludioxonil. Reviewed International journal

    Yoshimi A, Hagiwara D, Ono M, Fukuma Y, Midorikawa Y, Furukawa K, Fujioka T, Mizutani O, Sato N, Miyazawa K, Maruyama JI, Marui J, Yamagata Y, Nakajima T, Tanaka C, Abe K.

    Front Fungal Biol   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/ffunb.2021.675459.

  • Mitophagy reporter mouse analysis reveals increased mitophagy activity in disuse-induced muscle atrophy. Reviewed International journal

    Yamashita SI, Kyuuma M, Inoue K, Hata Y, Kawada R, Yamabi M, Fujii Y, Sakagami J, Fukuda T, Furukawa K, Tsukamoto S, Kanki T.

    J Cell Physiol   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jcp.30404.

  • Association and dissociation between the mitochondrial Far complex and Atg32 regulate mitophagy. Reviewed International journal

    Innokentev A, Furukawa K, Fukuda T, Saigusa T, Inoue K, Yamashita SI, Kanki T.

    eLife   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.7554/eLife.63694.

  • Atg43 tethers isolation membranes to mitochondria to promote starvation-induced mitophagy in fission yeast. Reviewed International journal

    Fukuda T, Ebi Y, Saigusa T, Furukawa K, Yamashita SI, Inoue K, Kobayashi D, Yoshida Y, Kanki T.

    eLife   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.7554/eLife.61245.

  • The PP2A-like protein phosphatase Ppg1 and the Far complex cooperatively counteract CK2-mediated phosphorylation of Atg32 to inhibit mitophagy. Reviewed International journal

    Furukawa K, Fukuda T, Yamashita SI, Saigusa T, Kurihara Y, Yoshida Y, Kirisako H, Nakatogawa H, Kanki T.

    Cell Rep   2018.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2018.05.064.

  • A fungicide-responsive kinase as a tool for synthetic cell fate regulation. Reviewed International journal

    Furukawa K, Hohmann S.

    Nucleic Acids Res   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/nar/gkv678.

  • Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy. Reviewed International journal

    Yamashita SI, Jin X, Furukawa K, Hamasaki M, Nezu A, Otera H, Saigusa T, Yoshimori T, Sakai Y, Mihara K, Kanki T.

    J Cell Biol   2016.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1083/jcb.201605093.

  • Differential role of HAMP-like linkers in regulating the functionality of the group III histidine kinase DhNik1p. Reviewed International journal

    Kaur H, Singh S, Rathore YS, Sharma A, Furukawa K, Hohmann S, Ashish, Mondal AK.

    J Biol Chem   2014.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M114.554303.

  • Rewiring yeast osmostress signalling through the MAPK network reveals essential and non-essential roles of Hog1 in osmoadaptation. Reviewed International journal

    Babazadeh R, Furukawa T, Hohmann S, Furukawa K.

    Sci Rep   2014.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep04697.

  • Fungal fludioxonil sensitivity is diminished by a constitutively active form of the group III histidine kinase. Reviewed International journal

    Furukawa K, Randhawa A, Kaur H, Mondal AK, Hohmann S.

    FEBS Lett   2012.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.febslet.2012.05.057.

  • The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction. Reviewed International journal

    Padamsee M, Kumar TK, Riley R, Binder M, Boyd A, Calvo AM, Furukawa K, Hesse C, Hohmann S, James TY, LaButti K, Lapidus A, Lindquist E, Lucas S, Miller K, Shantappa S, Grigoriev IV, Hibbett DS, McLaughlin DJ, Spatafora JW, Aime MC.

    Fungal Genet Biol   2012.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.fgb.2012.01.007.

  • Efficient construction of homozygous diploid strains identifies genes required for the hyper-filamentous phenotype in Saccharomyces cerevisiae. Reviewed International journal

    Furukawa K, Furukawa T, Hohmann S.

    PLoS One   2011.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0026584.

  • Distributed biological computation with multicellular engineered networks. Reviewed International journal

    Regot S, Macia J, Conde N, Furukawa K, Kjellén J, Peeters T, Hohmann S, de Nadal E, Posas F, Solé R.

    Nature   2010.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nature09679.

  • Expression of the yeast aquaporin Aqy2 affects cell surface properties under the control of osmoregulatory and morphogenic signalling pathways. Reviewed International journal

    Furukawa K, Sidoux-Walter F, Hohmann S.

    Mol Microbiol   2009.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1365-2958.2009.06933.x.

  • Alternative processing of proproteins in Aspergilli kexB gene disruptants under hyperosmotic conditions. Reviewed International journal

    Mizutani O, Furukawa K, Ichiyanagi S, Matsuda Y, Tokuoka M, Fujioka T, Yamagata Y, Gomi K, Abe K.

    Biosci Biotechnol Biochem   2009.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1271/bbb.80437.

  • Novel reporter gene expression systems for monitoring activation of the Aspergillus nidulans HOG pathway. Reviewed International journal

    Furukawa K, Yoshimi A, Furukawa T, Hoshi Y, Hagiwara D, Sato N, Fujioka T, Mizutani O, Mizuno T, Kobayashi T, Abe K.

    Biosci Biotechnol Biochem   2007.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1271/bbb.70131.

  • MpkA-Dependent and -independent cell wall integrity signaling in Aspergillus nidulans. Reviewed International journal

    Fujioka T, Mizutani O, Furukawa K, Sato N, Yoshimi A, Yamagata Y, Nakajima T, Abe K.

    Eukaryot Cell   2007.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/EC.00281-06.

  • The SskA and SrrA response regulators are implicated in oxidative stress responses of hyphae and asexual spores in the phosphorelay signaling network of Aspergillus nidulans. Reviewed International journal

    Hagiwara D, Asano Y, Marui J, Furukawa K, Kanamaru K, Kato M, Abe K, Kobayashi T, Yamashino T, Mizuno T.

    Biosci Biotechnol Biochem   2007.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1271/bbb.60665.

  • Characterization of the NikA histidine kinase implicated in the phosphorelay signal transduction of Aspergillus nidulans, with special reference to fungicide responses. Reviewed International journal

    Hagiwara D, Matsubayashi Y, Marui J, Furukawa K, Yamashino T, Kanamaru K, Kato M, Abe K, Kobayashi T, Mizuno T.

    Biosci Biotechnol Biochem   2007.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1271/bbb.70051.

  • Aspergillus nidulans HOG pathway is activated only by two-component signalling pathway in response to osmotic stress. Reviewed International journal

    Furukawa K, Hoshi Y, Maeda T, Nakajima T, Abe K.

    Mol Microbiol   2005.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1365-2958.2005.04605.x.

  • Disordered cell integrity signaling caused by disruption of the kexB gene in Aspergillus oryzae. Reviewed International journal

    Mizutani O, Nojima A, Yamamoto M, Furukawa K, Fujioka T, Yamagata Y, Abe K, Nakajima T.

    Eukaryot Cell   2004.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/EC.3.4.1036-1048.2004.

  • Isolation and functional analysis of a gene, tcsB, encoding a transmembrane hybrid-type histidine kinase from Aspergillus nidulans. Reviewed International journal

    Furukawa K, Katsuno Y, Urao T, Yabe T, Yamada-Okabe T, Yamada-Okabe H, Yamagata Y, Abe K, Nakajima T.

    Appl Environ Microbiol   2002.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/AEM.68.11.5304-5310.2002.

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Books

  • Mitophagy in yeast: a screen of mitophagy-deficient mutants.

    Furukawa K, Kanki T.(Role:Joint author)

    Humana Press  2017.3 

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    Language:English   Book type:Scholarly book

    DOI: 10.1007/7651_2017_13.

  • Novel industrial applications of Aspergillus oryzae genomics.

    Abe, K., Furukawa, K., Fujioka, T., Hagiwara, D., Maeda, H., Marui, J., Mizutani, O., Takahashi, T., Yoshimi, A., Yamagata, Y., Gomi, K. and Hasegawa, F.(Role:Joint author)

    Caister Academic Press  2010.1 

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    Language:English   Book type:Scholarly book

Presentations

  • ミトコンドリア型Far複合体とAtg32の結合と解離によるマイトファジー制御

    古川健太郎、Aleksei Innokentev、福田智行、神吉智丈

    酵母遺伝学フォーラム・第53回研究報告会  2020.9 

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    Event date: 2020.9

    Language:Japanese  

    Country:Japan  

  • マイトファジーの抑制に関与するプロテインホスファターゼPpg1とFar複合体の解析

    古川健太郎、Aleksei Innokentev、福田智行、神吉智丈

    酵母遺伝学フォーラム・第52回研究報告会  2019.9 

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    Event date: 2019.9

    Language:Japanese  

    Venue:静岡県   Country:Japan  

  • 酵母におけるミトコンドリアオートファジーの抑制機構

    古川健太郎、神吉智丈

    第18回日本ミトコンドリア学会年会  2018.12 

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    Event date: 2018.12

    Language:Japanese  

    Venue:福岡県   Country:Japan  

  • 酵母におけるミトコンドリアオートファジーの負の制御機構

    古川健太郎、神吉智丈

    第18回糸状菌分子生物学コンファレンス  2018.11 

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    Event date: 2018.11

    Language:Japanese  

    Venue:新潟県   Country:Japan  

  • ミトコンドリアオートファジーレセプターAtg32の負の制御機構

    古川健太郎、神吉智丈

    酵母遺伝学フォーラム・第50回研究報告会  2017.9 

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    Event date: 2017.9

    Language:Japanese  

    Venue:東京都   Country:Japan  

  • Negative regulatory mechanisms of the yeast mitophagy receptor Atg32 International conference

    Kentaro Furukawa, Yusuke Kurihara, Tomotake Kanki

    8th International Symposium on Autophagy  2017.5 

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    Event date: 2017.5 - 2017.6

    Language:English  

    Venue:奈良県   Country:Japan  

  • 出芽酵母におけるミトコンドリアオートファジーの制御機構

    古川健太郎、神吉智丈

    酵母遺伝学フォーラム・第49回研究報告会  2016.9 

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    Event date: 2016.9

    Language:Japanese  

    Venue:兵庫県   Country:Japan  

  • マイトファジーレセプターAtg32の負の制御機構

    古川健太郎、栗原悠介、神吉智丈

    ミトコンドリアワークショップ2016  2016.7 

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    Event date: 2016.7

    Language:Japanese  

    Venue:福岡県   Country:Japan  

  • 抗真菌剤の標的キナーゼを用いたMAPKシグナリングの改変

    古川健太郎、Stefan Hohmann

    酵母遺伝学フォーラム・第48回研究報告会  2015.8 

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    Event date: 2015.8 - 2015.9

    Language:Japanese  

    Venue:広島県   Country:Japan  

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MISC

  • Re-exploration of all ATG genes

    Furukawa K., Ginevskaia T., Kanki T.

    Autophagy Reports   3 ( 1 )   2386194   2024

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    Language:English   Publisher:Autophagy Reports  

    Most autophagy-related (ATG) genes have been identified and characterized through studies using the budding yeast Saccharomyces cerevisiae. However, there are no studies that comprehensively compare the contribution of each ATG gene to non-selective bulk autophagy and various types of selective autophagy, including the cytoplasm-to-vacuole targeting (Cvt) pathway, mitophagy, reticulophagy, and pexophagy. Our recent study quantified these types of autophagy in all atg mutants and showed that (i) autophagy is not completely impaired in specific deletants such as lacking the components of the two ubiquitin conjugation-like (UBL) systems, traditionally regarded as essential for autophagy in yeast, and (ii) residual autophagic activity is especially prominent in mutants of the Atg8 UBL system, which display small autophagic body-like vesicles at a low frequency. Alongside these findings, our comprehensive analysis suggested a link between mitophagy and pexophagy, and a differential contribution of Atg proteins to cargo specificity. We discuss how our datasets are useful for future autophagy research. Abbreviations: Ape1: aminopeptidase I; ATG: autophagy related; Cvt: cytoplasm-to-vacuole targeting; ER: endoplasmic reticulum; ESCRT: endosomal sorting complex required for transport; GFP: green fluorescent protein; PI3K: phosphatidylinositol 3-kinase; UBL: ubiquitin conjugation-like.

    DOI: 10.1080/27694127.2024.2386194

    Scopus

    PubMed

  • Mitofissin: a novel mitochondrial fission protein that facilitates mitophagy. Reviewed

    Fukuda T, Furukawa K, Maruyama T, Noda NN, Kanki T.

    Autophagy   2023.7

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1080/15548627.2023.2237343.

  • Meet the authors: Tomoyuki Fukuda, Kentaro Furukawa, and Tomotake Kanki.

    Fukuda T, Furukawa K, Kanki T.

    Mol Cell   2023.6

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    Language:English  

  • Mitophagy regulation mediated by the Far complex in yeast. Reviewed

    Furukawa K, Innokentev A, Kanki T.

    2021.2

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1080/15548627.2021.1885184.

  • Regulatory mechanisms of mitochondrial autophagy: lessons from yeast. Reviewed

    Furukawa K, Innokentev A, Kanki T.

    Front Plant Sci   2019.11

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.3389/fpls.2019.01479.

  • PP2A-like protein phosphatase Ppg1: an emerging negative regulator of mitophagy in yeast. Reviewed

    Furukawa K, Kanki T.

    Autophagy   2018.9

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1080/15548627.2018.1511505.

  • Mitophagy in yeast: Molecular mechanisms and physiological role. Reviewed

    Kanki T, Furukawa K, Yamashita S.

    Biochim Biophys Acta   2015.1

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1016/j.bbamcr.2015.01.005.

  • Synthetic biology: lessons from engineering yeast MAPK signalling pathways. Reviewed

    Furukawa K, Hohmann S.

    Mol Microbiol   2013.3

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1111/mmi.12174.

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Industrial property rights

Patent   Number of applications: 0   Number of registrations: 2
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • Yeast Genetics Society of Japan

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:3

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:2

  • Screening of academic papers

    Role(s): Peer review

    2018

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:2

  • Screening of academic papers

    Role(s): Peer review

    2016

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

  • Screening of academic papers

    Role(s): Peer review

    2015

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

Research Projects

  • Elucidation of the mechanism of mitochondrial fission driven by novel factors

    Grant number:24K01717  2024 - 2026

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    古川 健太郎, 神吉 智丈

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    Authorship:Principal investigator  Grant type:Scientific research funding

    エネルギー産生を担うミトコンドリアは、分裂と融合によるダイナミックな形態変化を示し、この形態制御はミトコンドリアの恒常性維持において極めて重要である。形態制御の破綻、例えば、分裂因子Drp1の変異は神経変性疾患などの病態を引き起こすが、根本的な治療法は見つかっていない。申請者らは、酵母を用いたミトコンドリア分解機構の研究過程において、Drp1とは完全に異なる新規分裂因子Atg44およびそのパラログを同定している。本研究では、これら新規因子を介したミトコンドリア分裂機構の全容解明に加え、遺伝子治療を見据えたDrp1変異細胞の表現型を回復させるAtg44の異種発現系の構築に挑む。

    CiNii Research

  • 研究助成「Atg44とDnm1の連携作用を介したミトコンドリア分裂機構の解明」

    2024

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    Grant type:Donation

  • Functions and molecular mechanisms of mitochondrial microproteins

    Grant number:23H04255  2023 - 2024

    Japan Society for the Promotion of Science・Ministry of Education, Culture, Sports, Science and Technology  Grants-in-Aid for Scientific Research  Grant-in-Aid for Transformative Research Areas (A)

    古川 健太郎

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    Authorship:Principal investigator  Grant type:Scientific research funding

    本研究は、酵母のミトコンドリアに局在する100アミノ酸に満たないマイクロタンパク質群が、どのようにミトコンドリアの各種機能に関与するのか、さらには機能発揮の分子機構を解明し、それぞれの短いアミノ酸配列に隠された意義を見出すことを目指す。この目的のために次の二つの研究を遂行する。①ミトコンドリアプロテオーム解析で局在のみが明らかとなっているマイクロタンパク質群のミトコンドリアの呼吸機能・形態制御・品質管理などにおける役割と機能発揮の分子機構の解明。②マイクロタンパク質群の中から先行して見出した新規因子が駆動するミトコンドリア分裂の分子機構の解明。

    CiNii Research

  • 一般研究助成「ミトコンドリアに眠る機能未知の小さなタンパク質群の網羅的解析」

    2023

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    Grant type:Donation

  • マイトファジーの誘導から分解に至る一連の分子機構と生理的意義の解明

    Grant number:21K05500  2021 - 2023

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 一般研究助成「オートファジーから逃れるタンパク質の網羅的解析」

    2020

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    Grant type:Donation

  • 医学系研究継続助成(基礎)「マイトファジーレセプターAtg32の負の制御機構の解析」

    2019

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    Grant type:Donation

  • 酵母におけるミトコンドリアオートファジーの制御機構と生理的意義の統合的理解

    Grant number:18K06129  2018 - 2020

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 奨励研究助成「ミトコンドリアオートファジーによる分解標的のオミックス解析」

    2018

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    Grant type:Donation

  • ストレス応答キナーゼを介したマイトファジー制御機構の解明と人工制御

    Grant number:16K18514  2016 - 2017

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists(A)or(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 医学系研究奨励(基礎)「マイトファジーレセプターAtg32の負の制御機構の解析」

    2016

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    Grant type:Donation

  • ストレス応答キナーゼによるマイトファジー制御機構の解明

    Grant number:15H06223  2015

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Research Activity start-up

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • アスペルギス属カビの高浸透圧応答シグナル伝達系に関する研究

    Grant number:04J03318  2004 - 2005

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for JSPS Fellows

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    Authorship:Principal investigator  Grant type:Scientific research funding

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Educational Activities

  • 「Physiology」and「Physiology Practice」in School of Medicine.
    「Human Body Structure and Function III」in the Master's Program in Graduate School of Medical Sciences.

Class subject

  • 生理学

    2025.4 - 2025.9   First semester

  • 人体構造と機能III

    2025.4 - 2025.9   First semester

  • 人体構造と機能III

    2024.4 - 2024.9   First semester

  • 生理学実習

    2024.4 - 2024.9   First semester

  • 生理学

    2024.4 - 2024.9   First semester

FD Participation

  • 2024.4   Role:Participation   Title:令和6年度 第1回全学FD(新任教員の研修)The 1st All-University FD (training for new faculty members) in FY2024

    Organizer:University-wide

Media Coverage

  • 新規ミトコンドリア分裂因子を発見 新潟大グループ、関連疾患治療目指す マイトファジー時の 分裂メカニズム解明 Newspaper, magazine

    科学新聞  2023.5

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    新規ミトコンドリア分裂因子を発見 新潟大グループ、関連疾患治療目指す マイトファジー時の 分裂メカニズム解明

  • ミトコンドリアの恒常性維持 「マイトファジー」制御機構解明 ~新潟大グループが成果~ Newspaper, magazine

    科学新聞  2021.1

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    ミトコンドリアの恒常性維持 「マイトファジー」制御機構解明 ~新潟大グループが成果~

  • ミトコンドリアの自食作用・特定酵素が抑制 ~新潟大など仕組み解明~ Newspaper, magazine

    日本経済新聞  2018.6

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    ミトコンドリアの自食作用・特定酵素が抑制 ~新潟大など仕組み解明~

Travel Abroad

  • 2006.5 - 2015.1

    Staying countory name 1:Sweden   Staying institution name 1:ヨーテボリ大学