2025/06/24 更新

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写真a

モウリ タロウ
毛利 太郎
MORI TARO
所属
医学研究院 基礎医学部門 助教
医学系学府 医療経営・管理学専攻(併任)
医学部 医学科(併任)
職名
助教
連絡先
メールアドレス
電話番号
0926426072
外部リンク

研究分野

  • ライフサイエンス / 人体病理学

学位

  • 2023年3月 九州大学, 博士 (医学)

経歴

  • 九州大学 医学研究院 基礎医学部門  助教 

    2023年4月 - 現在

学歴

  • 九州大学   大学院医学研究院  

    2019年4月 - 2023年3月

  • 信州大学   医学部   医学科

    2007年4月 - 2013年3月

研究テーマ・研究キーワード

  • 研究テーマ: 骨軟部腫瘍における治療標的・予後因子の解明

    研究キーワード: 骨軟部腫瘍, 病理

    研究期間: 2023年4月 - 2027年3月

論文

  • <i>DDIT3</i>-amplified or low-polysomic pleomorphic sarcomas without<i> MDM2</i> amplification: Clinicopathological review and immunohistochemical profile of nine cases 査読 国際誌

    Mori, T; Iwasaki, T; Sonoda, H; Kawaguchi, K; Tomonaga, T; Furukawa, H; Sato, C; Shiraishi, S; Taguchi, K; Tamiya, S; Yoneda, R; Oshiro, Y; Matsunobu, T; Abe, C; Kuboyama, Y; Ueki, N; Kohashi, K; Yamamoto, H; Nakashima, Y; Oda, Y

    HUMAN PATHOLOGY   145   56 - 62   2024年3月   ISSN:0046-8177 eISSN:1532-8392

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Human Pathology  

    Several high-grade pleomorphic sarcoma cases that cannot be classified into any existing established categories have been reported. These cases were provisionally classified into undifferentiated pleomorphic sarcoma (UPS). Some dedifferentiated liposarcoma (DDLS) cases may also have been classified into the UPS category due to the absence of MDM2 amplification or an atypical lipomatous tumor/well-differentiated liposarcoma component. We retrieved and reviewed 77 high-grade pleomorphic sarcoma cases, initially diagnosed as UPS in 66 cases and DDLS in 11 cases. Fluorescence in situ hybridization (FISH) analyses of DDIT3 and MDM2 were performed for available cases. Of the cases successfully subjected to DDIT3 FISH (n = 56), nine (7 UPS and 2 DDLS) showed DDIT3 amplification but no MDM2 amplification. Two UPS cases showed both telomeric (5′) and centromeric (3′) amplification of DDIT3 or low polysomy of chromosome 12, whereas 5 UPS and 2 DDLS cases showed 5′-predominant DDIT3 amplification. Histopathologically, all cases showed UPS-like proliferation of atypical pleomorphic tumor cells. Immunohistochemically, only one case showed focal nuclear positivity for DDIT3, supporting the previous finding that DDIT3 expression was not correlated with DDIT3 amplification. All three cases with focal MDM2 expression involved 5′-predominant amplification, two of which showed DDLS-like histological features. The majority of cases (7/9) showed decreased expression in p53 staining, suggesting that DDIT3 amplification regulates the expression of TP53 like MDM2. From a clinicopathological perspective, we hypothesize that DDIT3-amplified sarcoma, especially with 5′-predominant amplification, can be reclassified out of the UPS category.

    DOI: 10.1016/j.humpath.2024.02.007

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  • Clinicopathological and histopathological review of dedifferentiated liposarcoma: a comprehensive study of 123 primary tumours. 査読 国際誌

    Mori T, Yamada Y, Kinoshita I, Kohashi K, Yamamoto H, Ito Y, Susuki Y, Kawaguchi K, Nakashima Y, Oda Y

    HISTOPATHOLOGY   80 ( 3 )   538 - 557   2022年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Aims: Dedifferentiated liposarcoma (DDLS) has varying histopathological features, but their significance for the biological behaviour of this disease has not been fully clarified. The aim of this study was to elucidate the prognostic factors for DDLS by clinicopathologically reviewing a large case series.
    Methods and results: We clinicopathologically reviewed 123 cases of primary de-novo DDLS without preoperative treatment, including 81 in the internal trunk (internal DDLS) and 42 in peripheral sites (peripheral DDLS). Univariate and multivariate analyses of their features were also performed for all cases, the internal DDLS group, and the peripheral DDLS group. The results showed that, in all three groups, distant metastasis was significantly associated with shorter overall survival (OS) (univariate analysis, P < 0.0001, P = 0.0011, and P = 0.0101, respectively), whereas local recurrence showed no significant effect on prognosis. Histopathologically, a high mitotic count and the presence of round tumour cells were significantly associated with shorter OS in multivariate analysis of the internal DDLS group [respectively: P = 0.0022, hazard ratio (HR) 4.39, 95% confidence interval (CI) 1.71-11.28; and P = 0.0014, HR 7.19, 95% CI 2.14-24.16]. In the peripheral DDLS group, necrosis and high-grade histological components were significantly associated with shorter OS (univariate analysis, P = 0.0068 and P = 0.0174, respectively).
    Conclusions: The presence of round tumour cells may be one of the histological factors associated with a worse prognosis of DDLS patients, as previous studies indicated. This study also suggests that distant metastasis may be predictive of prognosis for both internal and peripheral DDLS, rather than local recurrence.

    DOI: 10.1111/his.14588.

  • Squamous cell carcinoma arising in sacrococcygeal teratoma in an adult: A case report 査読

    Tanaka, Y; Nakanishi, R; Hazama, H; Mori, T; Kawazoe, T; Kudou, K; Zaitsu, Y; Hisamatsu, Y; Ando, K; Oki, E; Aishima, S; Oda, Y; Yoshizumi, T

    HUMAN PATHOLOGY REPORTS   40   2025年6月   eISSN:2772-736X

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    記述言語:英語   出版者・発行元:Human Pathology Reports  

    Sacrococcygeal teratomas (SCT) with malignant transformation to squamous cell carcinoma are extremely rare, with only few cases reported in the literature. Herein, we report on a case of a primary sacrococcygeal mature cystic teratoma with malignant transformation into a squamous cell carcinoma. A 53-year-old woman presented with dysuria and lower abdominal pain caused by a huge SCT. Computed tomography (CT), magnetic resonance imaging, and positron emission tomography/CT findings were suggestive of SCT with malignant transformation. The treatment involved robotic-assisted laparoscopic abdominoperineal resection and bilateral lymph node dissection. Histopathology revealed squamous cell carcinoma within the teratoma. Postoperatively, the patient underwent six cycles of paclitaxel-carboplatin chemotherapy and showed no signs of recurrence during the 1-year follow-up.

    DOI: 10.1016/j.hpr.2025.300773

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  • Impact of Tertiary Lymphoid Structure on Prognosis and Tumor Microenvironment in Undifferentiated Pleomorphic Sarcoma 査読

    Sonoda, H; Iwasaki, T; Ishihara, S; Mori, T; Nakashima, Y; Oda, Y

    CANCER SCIENCE   116 ( 5 )   1464 - 1473   2025年5月   ISSN:1347-9032 eISSN:1349-7006

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Cancer Science  

    Undifferentiated pleomorphic sarcoma (UPS) has a favorable objective response rate to anti-PD-1 drugs compared with other sarcomas. Tertiary lymphoid structure (TLS) is a favorable prognostic factor and a biomarker for immune checkpoint inhibitors (ICIs). Nevertheless, there are limited data on the tumor microenvironment (TME) to support a good response to ICIs in sarcoma. Therefore, this study was conducted to investigate the impact of TLS on prognosis and TME. A total of 52 of UPS with wide resection were divided into intratumoral TLS, extratumoral TLS, and without TLS groups. Survival analysis and immunohistochemistry were performed to evaluate immune cells and immune checkpoint molecules, and multiplexed immunofluorescence was conducted to evaluate T-cell exhaustion among the three groups. TLS was detected in 34 cases (65%), including 23 intratumoral TLS (44%) and 11 extratumoral TLS (21%) cases. Patients with TLS had significantly longer overall survival than those without TLS (log rank p = 0.020). The intratumoral TLS group had a significantly higher number of immune cells and higher expression of PD-L1 and IDO-1 than the without TLS group. Progenitor-exhausted T cells were also observed in patients with UPS. In conclusion, these findings could help predict prognosis in patients with UPS. TLS was demonstrated to be a favorable prognostic factor in patients with UPS. Intratumoral TLS may be a biomarker for the response to ICIs, especially anti-PD-1 drugs.

    DOI: 10.1111/cas.70018

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  • Soft tissue tumor with <i>BRAF</i> and <i>NRAS</i> mutations sharing features with <i>NTRK</i>-rearranged spindle cell neoplasm: A case report expanding the spectrum of spindle cell tumor with kinase gene alterations 査読

    Kakuda, Y; Kato, I; Kawata, T; Goto, K; Ito, K; Satake, R; Toki, S; Murata, H; Wasa, J; Katagiri, H; Takahashi, M; Nagashima, T; Mori, T; Oda, Y; Sugino, T; Yamaguchi, K

    PATHOLOGY INTERNATIONAL   75 ( 1 )   40 - 45   2025年1月   ISSN:13205463 eISSN:1440-1827

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    記述言語:英語   出版者・発行元:Pathology International  

    NTRK-rearranged spindle cell neoplasm is a group of tumors characterized by NTRK1/2/3 gene fusion. Recently, tumors with other kinase fusion genes were reported to exhibit similar morphologies. Herein, we discuss an adult-onset soft tissue tumor with similar histologic patterns as kinase gene fusion-related tumors but with BRAF and NRAS mutations. A female in her 40s had a 40 mm tumor with an unclear border in the soft tissue of her foot joint. Short spindle-shaped tumor cell proliferation with abundant capillaries and collagen fiber bundles were observed. The tumor infiltrated the subcutaneous adipose tissue, exhibiting a lipofibromatosis-like pattern. Immunohistochemically, the tumor cells coexpressed CD34, S-100, and BRAF V600E. Whole-exome sequencing revealed BRAF p.V600E and NRAS p.Q61K mutations. Since BRAF activation occurs in BRAF fusion gene tumors and BRAF mutations, they could share a similar mechanism in tumorigenesis. This case suggests the further expansion of kinase-related spindle cell tumors.

    DOI: 10.1111/pin.13499

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  • A case of malignant spindle cell tumor of skull with BRAF V600E mutation 査読 国際誌

    Tsuchihashi, K; Nishiyori, S; Kusumoto, Y; Yoshihiro, T; Arimizu, K; Sangatsuda, Y; Komune, N; Hisano, O; Yoshitake, T; Hazama, H; Mori, T; Yoshimoto, K; Oda, Y; Akashi, K; Baba, E

    CANCER SCIENCE   116   380 - 380   2025年1月   ISSN:1347-9032 eISSN:1349-7006

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Clinical and pathological characteristics of immune checkpoint inhibitor-related fulminant myocarditis 査読

    Izumi, R; Hashimoto, T; Kisanuki, H; Ikuta, K; Otsuru, W; Asakawa, S; Yamamoto, S; Misumi, K; Fujino, T; Shinohara, K; Matsushima, S; Hosokawa, K; Katsuki, S; Mori, T; Hashisako, M; Tateishi, Y; Iwasaki, T; Oda, Y; Kinugawa, S; Abe, K

    CARDIO-ONCOLOGY   10 ( 1 )   82   2024年11月   eISSN:2057-3804

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Cardio Oncology  

    The advent of immune checkpoint inhibitors (ICIs) has significantly improved cancer treatment. With the increasing use of ICIs, ICI-related myocarditis has been recognized. However, an evidence-based therapeutic strategy has not been established because of the limited knowledge on ICI-related myocarditis. Here, we present four cases of ICI-related fulminant myocarditis (FM). Three of the four cases resulted in fatal outcomes despite aggressive treatment with mechanical circulatory support and immunosuppressive therapy with corticosteroids. Given the poor prognosis of ICI-FM, the establishment of rapid and adequate therapeutic interventions on the basis of clinical and pathological evaluation is imperative.

    DOI: 10.1186/s40959-024-00288-0

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  • Reappraisal of bone and soft tissue cytopathology classification using the modified Milan system 査読

    Naka, M; Yamamoto, H; Kohashi, K; Iwasaki, T; Mori, T; Nogami, M; Ookubo, F; Higuchi, K; Motoi, T; Oda, Y

    CANCER CYTOPATHOLOGY   132 ( 11 )   696 - 706   2024年11月   ISSN:1934-662X eISSN:1934-6638

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Cancer Cytopathology  

    Background: A standardized reporting system for bone and soft tissue tumor cytopathology has not yet been established. The objective of this study was to explore the potential utility of a classification modified from the Milan System for Salivary Gland Cytopathology and compared it with the upcoming World Health Organization (WHO) system for fine-needle aspiration of soft tissue lesions. Methods: The authors reviewed 285 cytology cases of bone/joint (n = 173) and soft tissue (n = 112) lesions, scoring each within diagnostic categories. The results were compared with histologic diagnoses and the risk of malignancy (ROM) for each category, and diagnostic reliability was analyzed. Results: All 285 cases were successfully classified into one of the following categories: nondiagnostic (6.3%), non-neoplastic (11.9%), atypia of uncertain significance (11.9%), benign neoplasm (5.6%), bone and soft tissue neoplasm of uncertain malignant potential (25.3%), suspicious for malignancy (1.4%), and malignant (37.5%). The ROM was 44.4% (eight of /18 cases) in nondiagnostic, 0% (zero of 34 cases) in non-neoplastic, 32.4% (11 of 34 cases) in atypia of uncertain significance, 0% (zero of 16 cases) in benign neoplasm, 16.7% (12 of 72 cases) in bone and soft tissue neoplasm of uncertain malignant potential, 75.0% (three of four cases) in suspicious for malignancy, and 100% (107 of 107 cases) in malignant categories. Using the WHO system, the proportion and ROM of the benign category (non-neoplastic and benign neoplasm) was 17.5% and 0%, respectively. Among benign and malignant lesions, the diagnostic accuracy, sensitivity, and specificity for detecting malignancy were 99.4%, 100%, and 98.0%, respectively. Conclusions: The modified Milan system as well as the WHO system may be a useful cytopathologic classification tool for both bone and soft tissue lesions.

    DOI: 10.1002/cncy.22888

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  • Prognostic implications of the immunohistochemical expression of perilipin 1 and adipophilin in high-grade liposarcoma 査読 国際誌

    Kawaguchi, K; Kohashi, K; Mori, T; Yamamoto, H; Iwasaki, T; Kinoshita, I; Susuki, Y; Furukawa, H; Endo, M; Matsumoto, Y; Nakashima, Y; Oda, Y

    JOURNAL OF CLINICAL PATHOLOGY   77 ( 10 )   676 - 682   2024年10月   ISSN:0021-9746 eISSN:1472-4146

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Clinical Pathology  

    Aims Liposarcoma is a malignant soft tissue tumour with adipocytic differentiation. Dedifferentiated liposarcoma (DDLS) and myxoid liposarcoma (MLS) are classified as high-grade liposarcomas. Lipid droplet-associated protein (also known as perilipin 1 (PLIN1)) is the predominant perilipin and has utility as a specific marker of adipogenic differentiation. Adipose differentiation-related protein (also known as adipophilin (ADRP)) is ubiquitously expressed in a range of tissues. High ADRP expression is reportedly a poor prognostic factor in several cancer types. However, no previous studies have examined the association between PLIN1 or ADRP expression and prognosis in sarcoma. This study therefore aimed to evaluate the association between PLIN1 or ADRP expression and prognosis in liposarcoma. Methods In total, 97 primary resection specimens (53 MLS and 44 DDLS) were examined in this study. PLIN1 and ADRP expression was evaluated by immunohistochemistry. Survival analyses were performed for MLS and DDLS. Results Of the 53 MLS specimens, 15 (28.3%) exhibited high PLIN1 expression. PLIN1 expression was not observed in DDLS specimens. High PLIN1 expression was significantly associated with increased disease-free survival (DFS) among patients with MLS (p=0.045). Distinct ADRP expression was observed in 13 of 53 (24.5%) MLS specimens and 5 of 44 (11.4%) DDLS specimens. High ADRP expression was associated with shorter overall survival (OS) in MLS (p=0.042) and DFS and shorter OS in DDLS (p=0.024 and p<0.001, respectively). Conclusions PLIN1 and ADRP expression is associated with poor prognosis in high-grade liposarcoma.

    DOI: 10.1136/jcp-2023-208814

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  • 胸壁に発生した筋肉内血管腫の切除例 症例報告(Resected intramuscular hemangioma in the chest wall: a case report)

    Nakanishi Yoshiyuki, Akamine Takaki, Kinoshita Fumihiko, Kohno Mikihiro, Ozono Keigo, Hino Takuya, Mori Taro, Oda Yoshinao, Takenaka Tomoyoshi, Nakamura Masafumi

    Surgical Case Reports   10   s40792 - 024   2024年9月

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    記述言語:英語   出版者・発行元:(一社)日本外科学会  

    症例は29歳男性で、定期検診時の胸部X線検査で右肺野に異常陰影がみられた。腫瘍マーカーを含む血液検査は正常であったが、CTでは第2肋間内に30mm大の境界明瞭な腫瘤を認め、MRIでもT2強調画像で高信号、T1強調画像で中程度の信号がみられた。神経鞘腫または孤発性線維性腫瘍が疑われたため、診断と治療を目的に胸腔鏡下手術を行った。腫瘍は第2肋軟骨前方の胸壁に認められ、表面は滑らかで胸膜と内側肋間筋に覆われていた。胸膜壁を腫瘍境界に沿って切開し、腫瘍を外側肋間筋および肋骨から剥離した。術後の病理組織学的検査では、毛細血管構造に配列された紡錘形の内皮細胞の増殖が認められ、これに伴って平滑筋線維、脂肪組織、筋肉血管が取り込まれていた。最終的に、切除断端陰性の筋肉内血管腫と診断した。術後経過は良好で、5日後に退院し、術後12ヵ月時点で再発の徴候は認められていない。

  • HER2陽性進行胃癌切除後2年で単独脳転移を呈した1例

    新垣 滉大, 大内田 研宙, 堤 親範, 進藤 幸治, 森山 大樹, 藤岡 寛, 下川 能史, 松本 崇雅, 毛利 太郎, 田村 公二, 永吉 絹子, 池永 直樹, 仲田 興平, 吉本 幸司, 小田 義直, 中村 雅史

    日本消化器外科学会雑誌   57 ( 7 )   326 - 333   2024年7月   ISSN:0386-9768

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    記述言語:日本語   出版者・発行元:(一社)日本消化器外科学会  

    症例は75歳の男性で,2020年進行胃癌に対して腹腔鏡下胃全摘術を施行した.病理診断で口側断端にリンパ管侵襲を認め非治癒切除と判断した.免疫染色検査でHER2[3+]であり,術後化学療法としてトラスツズマブ+カペシタビン+シスプラチン療法8コースとカペシタビン単剤療法を16コース施行した.術後約2年で左下肢の脱力感および転倒のため近医搬送となった.CTで転移性脳腫瘍を指摘され当院へ転院となった.その他の転移はなく,脳神経外科で開頭腫瘍摘出術を施行した.術後病理より胃癌の転移性腫瘍と判断した.トラスツズマブ投与後の頭蓋内単独再発例であったため,頭蓋内も含めた全身の治療効果を期待してニボルマブ単独投与を行い,術後6ヵ月現在無再発経過中である.今回,我々はHER2陽性進行胃癌の切除後に抗HER2療法を行い,その後に単独脳転移を呈した1例を経験したため報告する.(著者抄録)

  • Tracheomediastinal fistula induced by concurrent chemoradiotherapy in small cell lung cancer: A case report and literature review

    Yamamoto, Y; Shibahara, D; Mori, T; Otsubo, K; Shiraishi, Y; Yoneshima, Y; Iwama, E; Tanaka, K; Oda, Y; Okamoto, I

    THORACIC CANCER   15 ( 13 )   1106 - 1111   2024年5月   ISSN:1759-7706 eISSN:1759-7714

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    記述言語:英語   出版者・発行元:Thoracic Cancer  

    Tracheomediastinal fistula is a rare but life-threatening complication of cancer. We report a case of tracheomediastinal fistula induced by concurrent chemoradiotherapy in limited stage small cell lung cancer. Despite the treatment response, the metastatic paratracheal lymph node increased gradually during concurrent chemoradiotherapy, resulting in the occurrence of tracheomediastinal fistula and mediastinitis. Without any surgical intervention, the patient achieved successful recovery from mediastinitis through antibiotic treatment, although the tracheomediastinal fistula remained open. In this report, we also review previous studies of tracheomediastinal and bronchomediastinal fistulas and summarize the clinical features.

    DOI: 10.1111/1759-7714.15270

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  • Nuclear morphological atypia in biopsy accurately reflects the prognosis of myxoid liposarcoma 査読 国際誌

    Kawaguchi, K; Kohashi, K; Iwasaki, T; Mori, T; Furukawa, H; Sato, C; Sonoda, H; Shiraishi, S; Endo, M; Nakashima, Y; Oda, Y

    VIRCHOWS ARCHIV   486 ( 2 )   373 - 380   2024年3月   ISSN:0945-6317 eISSN:1432-2307

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Virchows Archiv  

    Currently, it is difficult to predict the prognosis of myxoid liposarcoma (MLS) in biopsy specimens. In this study, we determined whether nuclear morphology may be used to predict the prognosis of MLS in primary biopsy specimens. Two pathologists evaluated nuclear morphology using the modified WHO/ISUP and Fuhrman grades. Survival analyses were performed by grouping nuclear high- and low-grades. We examined 53 MLS cases, which included 29 (54.7%) male and 24 (45.3%) female patients with a median age of 46 years (interquartile range, 37 - 60). In total, 7 (13.2%) and 16 (30.2%) cases were assigned to the high nuclear grade group based on the modified WHO/ISUP and Fuhrman gradings, respectively. Survival analyses revealed a significantly worse disease-free survival in the high-grade group (hazard ratio (HR), 7.51; 95% confidence interval (CI), 2.67-21.1, p < 0.001 by the modified WHO/ISUP grading; HR, 4.45; 95% CI, 1.63-12.1, p = 0.001 by the modified Fuhrman grading). Moreover, the modified WHO/ISUP grade showed a significantly worse overall survival in the high-grade group (HR, 4.39; 95% CI, 1.04-18.6, p = 0.028), and the modified Fuhrman grade exhibited a similar, but not significant, trend. Our results indicate that nuclear morphology grading is a good predictor of patient prognosis at the time of biopsy in MLS. Even when cell density is sparse, treatment strategies should be carefully considered when individual tumor cells exhibit atypical nuclei.

    DOI: 10.1007/s00428-024-03796-7

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  • Subcutaneous Thyroid Tissue Implantation after Thyroidectomy: A Mimic of Benign Cutaneous Tumours 査読

    Takei, I; Ito, T; Mori, T; Oda, Y; Nakahara, T

    ACTA DERMATO-VENEREOLOGICA   103   adv00842   2023年   ISSN:0001-5555 eISSN:1651-2057

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    記述言語:英語   出版者・発行元:Acta Dermato Venereologica  

    DOI: 10.2340/actadv.v103.4407

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  • Myxoid type and non-myxoid type of intimal sarcoma in large vessels and heart: review of histological and genetic profiles of 20 cases 査読

    Yamada, Y; Kinoshita, I; Miyazaki, Y; Tateishi, Y; Kuboyama, Y; Iwasaki, T; Kohashi, K; Yamamoto, H; Ishihara, S; Toda, Y; Ito, Y; Susuki, Y; Kawaguchi, K; Hashisako, M; Yamada-Nozaki, Y; Kiyozawa, D; Mori, T; Yamamoto, T; Tsuchihashi, K; Kuriwaki, K; Mukai, M; Kawai, M; Suzuki, K; Nishimura, H; Bando, K; Masumoto, J; Fukushima, M; Motoshita, J; Mori, H; Shiose, A; Oda, Y

    VIRCHOWS ARCHIV   480 ( 4 )   919 - 925   2022年4月   ISSN:0945-6317 eISSN:1432-2307

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Virchows Archiv  

    Intimal sarcoma is one of the most common and well-known primary malignant neoplasms of the aorta and heart. The authors reviewed cases of intimal sarcoma from histological, immunohistochemical and genetic perspectives. Twenty cases of intimal sarcoma were retrieved. Immunohistochemistry and FISH of MDM2 and PDGFRA genes were performed. All 20 tumours were composed of spindle-shaped, stellate, oval or polygonal tumour cells with irregular hyperchromatic nuclei arranged in a haphazard pattern, accompanied by nuclear pleomorphism and frequent mitotic figures. Other histological findings were as follows: abnormal mitosis in 10 cases (50%), necrosis in 15 cases (75%), myxoid stroma in 12 cases (60%), cartilaginous formation in 1 case (5%), haemorrhage in 12 cases (60%) and fibrinous deposition in 14 cases (70%). The tumours were positive for MDM2 in 16 cases (80%), ERG in 4 cases (20%), alpha-smooth muscle actin in 6 cases (30%), desmin in 5 cases (25%) and AE1/AE3 in 4 cases (20%). Immunohistochemical positivity was focal in each case. Loss of H3K27me3 expression was noted in 2 cases (10%). MDM2 and PDGFRA gene amplifications were detected in 11 cases (55%) and 1 case (5%), respectively. Fisher’s exact test revealed a significant correlation between MDM2 gene amplification and myxoid stroma (p = 0.0194). No parameters showed any association with the anatomical location of the tumours. It was suggested that myxoid histology of intimal sarcoma may be associated with MDM2 gene amplification and that intimal sarcoma may be divided into myxoid and non-myxoid types.

    DOI: 10.1007/s00428-022-03293-9

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    PubMed

  • 下行結腸原発Histiocytic sarcomaの1例 査読

    阿部 千恵, 米田 玲子, 毛利 太郎, 山田 優衣, 山田 裕一, 小田 義直

    診断病理   39 ( 1 )   56 - 61   2022年1月   ISSN:1345-6431

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    記述言語:日本語   出版者・発行元:(一社)日本病理学会  

    Histiocytic sarcoma(HS)は稀な疾患で、とりわけ結腸発生例は数例しか報告がない。今回我々は下行結腸に発生したHSの1例を報告する。症例は47歳女性。内視鏡検査で下行結腸に腫瘤を認め、CTでリンパ節と肝臓への転移が疑われた。腸重積を来しており、左側結腸切除術が施行された。腫瘍は軟らかく淡褐色充実性で、組織学的に上皮様または組織球様の異型細胞がびまん性に増殖し、血球貪食像もみられた。免疫染色で異型細胞はCD68とCD163に陽性を示した。以上の所見よりHSと診断した。(著者抄録)

  • Clinicopathological and prognostic significance of H3K27 methylation status in malignant peripheral nerve sheath tumor: correlation with skeletal muscle differentiation. 査読 国際誌

    Ito Y, Kohashi K, Endo M, Yoshimoto M, Ishihara S, Toda Y, Susuki Y, Kawaguchi K, Furukawa H, Tateishi Y, Yamada Y, Kinoshita I, Mori T, Yamamoto H, Nakashima Y, Oda Y

    Virchows Archiv   479 ( 6 )   1233 - 1244   2021年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Malignant peripheral nerve sheath tumor (MPNST) is a very aggressive peripheral nerve sheath-derived sarcoma, which is one of the most difficult tumors to diagnose due to its wide spectrum of histological findings and lack of specific immunohistochemical markers. Recently, it has been reported that losses of expression of H3K27me3 and H3K27me2 caused by PRC2 dysfunction may be useful diagnostic markers for MPNST, but there is no consensus on their clinicopathological significance. Here, we investigated the relationship between loss of H3K27 methylation and various parameters and clarified the clinicopathological significance of such loss. We analyzed the clinicopathological and immunohistochemical features in 84 MPNST cases. Complete losses of H3K27me3 and H3K27me2 were observed in 37 (44%) and 29 (35%) cases, respectively. Losses of H3K27me3 and H3K27me2 were significantly correlated with myogenic immunopositivity (H3K27me3 vs. desmin, P = 0.0051; H3K27me3 vs. myogenin, P = 0.0009; H3K27me2 vs. myogenin, P = 0.042). Meanwhile, there were significant correlations between preservation of immunohistochemical neurogenic markers and intact H3K27me3 and H3K27me2 (H3K27me3 vs. S-100 protein, P = 0.0019; H3K27me3 vs. SOX10, P = 0.014; H3K27me2 vs. S-100 protein, P = 0.0011; H3K27me2 vs. SOX10, P = 0.0087). In multivariate analysis, local recurrence, distant metastasis, high FNCLCC grade, and loss of SOX10 expression were independent prognostic factors for overall survival. H3K27me3 and H3K27me2 expression was retained in all 26 cases of rhabdomyosarcoma non-alveolar subtype. In conclusion, we suggest that H3K27me3 and H3K27me2 immunonegativity is useful but not definitive for diagnosing MPNST. Complete loss of H3K27 methylation may be involved in aggressive transdifferentiation from neural differentiation to skeletal muscle differentiation in MPNST.

    DOI: 10.1007/s00428-021-03189-0.

  • Prognostic implication of desmoplastic stroma in synovial sarcoma: A histological review. 招待 査読 国際誌

    Toda Y, Yamada Y, Kohashi K, Ishihara S, Ito Y, Susuki Y, Kawaguchi K, Kinoshita I, Kiyozawa D, Mori T, Kuboyama Y, Tateishi Y, Yamamoto H, Fujiwara T, Setsu N, Endo M, Matsumoto Y, Nakashima Y, Mawatari M, Oda Y

    Pathology - Research and Practice   228 ( 153668 )   2021年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Synovial sarcoma (SS) is a malignant soft tissue neoplasm harboring SS18-SSX fusion gene and is histologically characterized by spindle cells and epithelial components. Some investigations have demonstrated that desmoplastic reaction (DR) is an independent prognostic factor of cancers. However, it remains unknown whether DR is of predictive value for the prognosis of synovial sarcoma patients. Here, we reviewed the clinical and histological findings of 88 patients with SS. We defined DR as hyalinized collagenous structures and classified the degree of DR as follows: none, mild, moderate, and severe. Overall, 23 SS cases (24%) showed moderate or severe DR histologically. Statistically, the cases with moderate or severe degree of DR showed poorer prognosis than those with no or mild DR (local recurrence: P = 0.0059, distant metastasis: P = 0.0002, tumor death: P = 0.0382). The findings of the study suggest that the DR of synovial sarcoma could be an important prognostic factor.

    DOI: 10.1016/j.prp.2021.153668.

  • Pathological review of cardiac amyloidosis using autopsy cases in a single Japanese institution. 査読 国際誌

    Tateishi Y, Yamada Y, Katsuki M, Nagata T, Yamamoto H, Kohashi K, Koga Y, Hashisako M, Kiyozawa D, Mori T, Kuboyama Y, Kakinokizono A, Miyazaki Y, Yamaguchi A, Tsutsui H, Ninomiya T, Naiki H, Oda Y

    Pathology - Research and Practice   227 ( 153635 )   2021年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Pathological review of cardiac amyloidosis using autopsy cases in a single Japanese institution.

    DOI: 10.1016/j.prp.2021.153635.

  • The association between the expression of PD-L1 and CMTM6 in undifferentiated pleomorphic sarcoma. 査読 国際誌

    Ishihara S, Iwasaki T, Kohashi K, Yamada Y, Toda Y, Ito Y, Susuki Y, Kawaguchi K, Takamatsu D, Kawatoko S, Kiyozawa D, Mori T, Kinoshita I, Yamamoto H, Fujiwara T, Setsu N, Endo M, Matsumoto Y, Nakashima Y, Oda Y

    Journal of Cancer Research and Clinical Oncology   147 ( 7 )   2003 - 2011   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: Undifferentiated pleomorphic sarcoma (UPS) is a sarcoma with a poor prognosis. A clinical trial, SARC028, revealed that treatment with anti-PD-1 drugs was effective against UPS. Studies have reported that UPS expresses PD-L1, sometimes strongly (≥ 50%). However, the mechanism of PD-L1 expression in UPS has remained unclear. CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) was identified as a novel regulator of PD-L1 expression. The positive relationship between PD-L1 and CMTM6 has been reported in several studies. The aim of this study was thus to examine CMTM6 expression in UPS and evaluate the relationship between PD-L1 and CMTM6 in this disease.
    Materials and methods: Fifty-one primary UPS samples were subjected to CMTM6 and PD-L1 immunostaining. CMTM6 expression was assessed using proportion and intensity scores. CMTM6 gene copy number was also evaluated using a real-time PCR-based copy number assay. We also analyzed the mRNA expression and copy number variation of PD-L1 and CMTM6 in The Cancer Genome Atlas (TCGA) data.
    Results: TCGA data indicated that the mRNAs encoded by genes located around 3p22 were coexpressed with CMTM6 mRNA in UPS. Both proportion and intensity scores of CMTM6 positively correlated with strong PD-L1 expression (≥ 50%) (both p = 0.023). CMTM6 copy number gain increased CMTM6 expression. Patients with UPS with a high CMTM6 intensity score had a worse prognosis for overall survival.
    Conclusions: UPS showed variation in CMTM6 copy number and CMTM6 expression. CMTM6 expression was significantly correlated with PD-L1 expression, especially with strong PD-L1 expression.

    DOI: 10.1007/s00432-021-03616-4.

  • A validation study of whole slide imaging for primary diagnosis of lymphoma. 査読 国際誌

    Amin S, Mori T, Itoh T

    Pathology International   69 ( 6 )   341 - 349   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Whole slide imaging (WSI) is being increasingly used worldwide. Although previous studies have asserted the validity of WSI diagnosis, they have primarily targeted only small specimens and excluded cases requiring immunohistochemistry or special staining, such as lymphoma. The purpose of this study was to evaluate the accuracy of WSI diagnosis of lymphoma, for which 240 biopsies and resections of lymphoma cases were selected from the study set of lymphomas. All slides including H&E, immunohistochemical and special staining were digitized using a WSI image scanner. An experienced pathologist performed the WSI diagnoses, which were compared with original diagnoses based on light microscopic examinations. Discrepancy between the two interpretations were classified into three categories: concordance, minor discrepancy (no clinical significance), and major discrepancy (with clinical significance). Overall concordance between the light microscopic and WSI diagnosis was found in 223 cases (92.92%; 95%CI = 88.90-95.82), minor discrepancy in fifteen (6.25%; 95%CI = 3.54-10.10), and major discrepancy in two (0.83%; 95%CI = 0.10-2.98). Diagnosis of lymphoma using WSI appeared to be mostly accurate, suggesting that WSI may be a reliable technology for the diagnosis of lymphoma.

    DOI: 10.1111/pin.12808.

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書籍等出版物

  • 骨・軟部腫瘍 臨床・画像・病理

    担当:共著)

    診断と治療社  2025年4月 

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    総ページ数:326   担当ページ:196-199, 202, 203   記述言語:日本語   著書種別:教科書・概説・概論

  • 歯学生のための基礎病理学

    担当:共著 範囲:XII 骨軟部組織の疾患)

    医歯薬出版株式会社  2024年5月 

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    総ページ数:403   担当ページ:335-344   記述言語:日本語   著書種別:教科書・概説・概論

講演・口頭発表等

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MISC

所属学協会

  • 日本病理学会

  • 日本臨床細胞学会

  • 日本癌学会

  • 日本臨床検査医学会

委員歴

  • 日本病理学会   評議員   国内

    2023年4月 - 現在   

学術貢献活動

  • Pathology International 国際学術貢献

    役割:査読

    2025年1月

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    種別:査読等 

教育活動概要

  • 学生が病理学の理解を得られるよう、分かりやすい講義を行うとともに、病理学研究の魅力を伝える。また、大学院生の指導を通じて、さらなる研究成果を挙げられるように努める。

担当授業科目

  • 病因と病態II

    2024年4月 - 2024年9月   前期

  • 系統医学Ⅱ:病理学(総論)

    2024年4月 - 2024年9月   前期

  • 系統医学Ⅱ:病理学(総論)

    2023年4月 - 2023年9月   前期

  • 病因と病態II

    2023年4月 - 2023年9月   前期

大学全体における各種委員・役職等

  • 2024年4月 - 現在   希少がんセンター運営委員会

社会貢献・国際連携活動概要

  • 自らが庶務として運営中である日本骨軟部腫瘍研究会(BTC)の普及に努める。また、他施設からの難解例のコンサルト診断に携わり、国内の骨軟部病理診断精度の向上に貢献する。

社会貢献活動

  • 日本骨軟部腫瘍研究会

    役割:運営参加・支援

    2022年1月 - 現在

専門診療領域

  • 生物系/医歯薬学/基礎医学/人体病理学

臨床医資格

  • 指導医

    日本臨床細胞学会

  • 指導医

    日本病理学会

  • 認定医

    日本臨床検査医学会

医師免許取得年

  • 2013年