FUJIMOTO SATOSHI
Organization
Faculty of Medical Sciences Research Center for Human Disease Modeling Assistant Professor
Faculty of Medical Sciences Research Center for Human Disease Modeling（Concurrent）
School of Medicine Department of Medicine（Concurrent）
Title
Assistant Professor
Contact information
Profile
マウス嗅覚系を用いて、神経回路形成機構について研究している
Homepage
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https://www.lab.med.kyushu-u.ac.jp/dn-en/
Department of Developmental Neurophysiology
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http://researchmap.jp/satoshifujimoto/?lang=english
researchmap
External link
ORCID
Degree
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Ph.D.
Research History
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2010.4-2011.7 千葉大学 2011.8-2017.3 理化学研究所
Research Interests・Research Keywords
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Research theme：Mechanisms of activity-dependent neural circuit formation
Keyword：Neural circuit formation
Research period： 2017.4
Papers
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Activity-dependent local protection and lateral inhibition control synaptic competition in developing mitral cells in mice Reviewed International journal
@Satoshi Fujimoto, @Marcus N. Leiwe, #Shuhei Aihara, @Richi Sakaguchi, @Yuko Muroyama, @Reiko Kobayakawa, @Ko Kobayakawa, @Tetsuichiro Saito, @Takeshi Imai
Developmental Cell 58 ( 14 ) 1221 - + 2023.6 （ ISSN:1534-5807 eISSN:1878-1551 ）
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Leiwe, MN; Fujimoto, S; Baba, T; Moriyasu, D; Saha, B; Sakaguchi, R; Inagaki, S; Imai, T
NATURE COMMUNICATIONS 15 ( 1 ) 5279 2024.6 （ eISSN:2041-1723 ）
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Microglia are dispensable for developmental dendrite pruning of mitral cells in mice Reviewed International journal
#Tetsushi Niiyama, @Satoshi Fujimoto, @Takeshi Imai
eNeuro 10 ( 11 ) 2023.10 （ eISSN:2373-2822 ）
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第5土曜特集 生体イメージングの最前線--絶え間ない技術革新と生命医科学の新展開 イメージングで神経活動を解析する 発達期の樹状突起刈り込みを制御するシナプス競合のメカニズム
藤本 聡志, 今井 猛
医学のあゆみ 286 ( 5 ) 365 - 371 2023.7 （ ISSN:00392359 ）
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Effective Hand Rearing of Neonatal Mice for Developmental Studies Reviewed International journal
@Marcus N Leiwe, @Satoshi Fujimoto, @Takeshi Imai
Bio-protocol 13 ( 11 ) e4755 2023.6 （ eISSN:2331-8325 ）
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The Japanese Journal of Taste and Smell Research 30 ( 2 ) 101 - 109 2023 （ ISSN:13404806 eISSN:24241326 ）
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Post hoc Correction of Chromatic Aberrations in Large-Scale Volumetric Images in Confocal Microscopy Invited Reviewed International journal
@Marcus N Leiwe, @Satoshi Fujimoto, @Takeshi Imai
FRONTIERS IN NEUROANATOMY 15 2021.12
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BMPR-2 gates activity-dependent stabilization of primary dendrites during mitral cell remodeling Reviewed International journal
@Aihara Shuhei, @Fujimoto Satoshi, @Sakaguchi Richi, @Imai Takeshi
CELL REPORTS 35 ( 12 ) 2021.6
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Aya Murai, Ryo Iwata, Satoshi Fujimoto, Shuhei Aihara, Akio Tsuboi, Yuko Muroyama, Tetsuichiro Saito, Kazunori Nishizaki, Takeshi Imai
eNeuro 3 ( 5 ) 2016.10
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Super-Resolution Mapping of Neuronal Circuitry With an Index-Optimized Clearing Agent Reviewed
Meng Tsen Ke, Yasuhiro Nakai, Satoshi Fujimoto, Rie Takayama, Shuhei Yoshida, Tomoya S. Kitajima, Makoto Sato, Takeshi Imai
Cell Reports 14 ( 11 ) 2718 - 2732 2016.3
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Optical Clearing Using SeeDB Invited Reviewed International journal
Meng-Tsen Ke, Satoshi Fujimoto, Takeshi Imai
Bio-protocol 2014.2
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SeeDB A simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction Reviewed
Meng Tsen Ke, Satoshi Fujimoto, Takeshi Imai
Nature Neuroscience 16 ( 8 ) 1154 - 1161 2013.8
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Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism Reviewed
Nao Hiramoto-Yamaki, Shingo Takeuchi, Shuhei Ueda, Kohei Harada, Satoshi Fujimoto, Manabu Negishi, Hironori Katoh
Journal of Cell Biology 190 ( 3 ) 461 - 477 2010.8
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RhoG promotes neural progenitor cell proliferation in mouse cerebral cortex Reviewed
Satoshi Fujimoto, Manabu Negishi, Hironori Katoh
Molecular Biology of the Cell 20 ( 23 ) 4941 - 4950 2009.12
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Plexin-B1 is a GTPase activating protein for M-Ras, remodelling dendrite morphology Reviewed
Yasuhiro Saito, Izumi Oinuma, Satoshi Fujimoto, Manabu Negishi
EMBO Reports 10 ( 6 ) 614 - 621 2009.6
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Dock4 regulates dendritic development in hippocampal neurons Reviewed
Shuhei Ueda, Satoshi Fujimoto, Kiyo Hiramoto, Manabu Negishi, Hironori Katoh
Journal of Neuroscience Research 86 ( 14 ) 3052 - 3061 2008.11
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Differential distribution of ELMO1 and ELMO2 mRNAs in the developing mouse brain Reviewed
Hironori Katoh, Satoshi Fujimoto, Chisaki Ishida, Yukio Ishikawa, Manabu Negishi
Brain Research 1073-1074 ( 1 ) 103 - 108 2006.2
Presentations
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Activity-dependent local protection and lateral inhibition control developmental dendrite pruning in mitral cells International conference
@Satoshi Fujimoto, @Marcus Leiwe, #Shuhei Aihara, @Richi Sakaguchi, @Yuko Muroyama, @Reiko Kobayakawa, @Ko Kobayakawa, @Tetsuichiro Saito, @Takeshi Imai
Axon 2023 - Development, Plasticity & Regeneration of Neural Circuits 2023.9
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Activity-dependent lateral inhibition signals for synaptic competition International conference
Satoshi Fujimoto, Marcus Leiwe, Shuhei Aihara, Richi Sakaguchi, Yuko Muroyama, Reiko Kobayakawa, Ko Kobayakawa, Tetsuichiro Saito, Takeshi Imai
EMBO Workshop - Mechanisms of neuronal remodelling 2023.3
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Activity-dependent competition within a neuron ensures the discrete wiring of mitral cell dendrites International conference
@Satoshi Fujimoto, @Marcus N. Leiwe, @Shuhei Aihara, @Richi Sakaguchi, @Yuko Muroyama, @Reiko Kobayakawa, @Ko Kobayakawa, @Tetsuichiro Saito, @Takeshi Imai
2021.7
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Activity-dependent competition within a neuron ensures the discrete wiring of mitral cell dendrites
@Satoshi Fujimoto, @Takeshi Imai
2020.12
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Activity-dependent competition within a neuron ensures the discrete wiring of mitral cell dendrites International conference
@Satoshi Fujimoto, @Marcus N. Leiwe, Shuhei Aihara, Richi Sakaguchi, Yuko Muroyama, Reiko Kobayakawa, Ko Kobayakawa, Tetsuichiro Saito, @Takeshi Imai
CSHL Meeting Molecular Mechanisms of Neuronal Connectivity 2020.9
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生後発達期の嗅球における自発神経活動依存的な回路形成 Invited
藤本聡志
第42回日本分子生物学会 2019.12
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Mechanisms of synaptic competition for establishing the “one mitral cell – one glomerulus” connection rule Invited International conference
2023.11
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発達期の樹状突起刈り込みを制御するシナプス競合の分子機構
@藤本聡志、@Marcus N. Leiwe、#藍原周平、@坂口理智、@室山優子、@小早川令子、@小早川高、@斎藤哲一郎、@今井猛
第96回日本生化学会大会 2023.10
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Activity-dependent lateral inhibition signals establish a discrete receptive field of a neuron International conference
@Satoshi Fujimoto, @Marcus N Leiwe, #Shuhei Aihara, @Richi Sakaguchi, @Yuko Muroyama, @Reiko Kobayakawa, @Ko Kobayakawa, @Tetsuichiro Saito, @Takeshi Imai
2023.8
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シナプス競合による樹状突起刈り込みのメカニズム
藤本聡志
第5回これからの神経回路研究の会 2023.3
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BMPR-2 gates activity-dependent stabilization of dendrites during mitral cell remodeling International conference
Shuhei Aihara, Satoshi Fujimoto, Richi Sakaguchi, Takeshi Imai
2021.7
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Selective dendrite stabilization is controlled by BMPR2 in developing mitral cells International conference
@Shuhei Aihara, @Satoshi Fujimoto, @Richi Sakaguchi, @Takeshi Imai
CSHL Meeting Molecular Mechanisms of Neuronal Connectivity 2020.9
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Spontaneous Activity-Dependent Discrete Circuit Formation in the Developing Olfactory Bulb Invited International conference
Satoshi Fujimoto
2019.3
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発達期の嗅球における自発神経活動依存的な神経回路形成
藤本聡志
第69回西日本生理学会 2018.10
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Moriyasu Daichi, Kamizono Fuyuki, Saha Biswanath, Takeshima Hikari, Ishida Yuki, Fujimoto Satoshi, Imayoshi Itaru, Imai Takeshi
The Journal of Physiological Sciences 2024.5 (一社)日本生理学会
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腸内感覚を担う迷走神経のin vivoカルシウムイメージング
武島 光里, 藤本 聡志, 稲垣 成矩, 今井 猛
日本生理学雑誌 2022.2 (一社)日本生理学会
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藤本 聡志, Leiwe Marcus N., 藍原 周平, 坂口 理智, 室山 優子, 小早川 令子, 小早川 高, 斎藤 哲一郎, 今井 猛
日本生化学会大会プログラム・講演要旨集 2023.10 (公社)日本生化学会
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Moriyasu Daichi, Kamizono Fuyuki, Saha Biswanath, Takeshima Hikari, Ishida Yuki, Fujimoto Satoshi, Imayoshi Itaru, Imai Takeshi
The Journal of Physiological Sciences 2024.5 (一社)日本生理学会
MISC
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僧帽細胞が樹状突起刈り込みによって単一の主樹状突起を確立するための シナプス競合の仕組み Reviewed
@藤本聡志
日本神経科学学会 神経科学ニュース 2024.2
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嗅球における1僧帽細胞-1糸球体接続ルールを保証するシナプス競合の仕組み Reviewed
@藤本聡志, @今井猛
日本味と匂学会誌 2023.11
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嗅球における1僧帽細胞-1糸球体接続ルールを保証するシナプス競合の仕組み
藤本 聡志, 今井 猛
日本味と匂学会誌 30 ( 2 ) 101 - 108 2023.11 （ ISSN:1340-4806 ）
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発達期の樹状突起刈り込みを制御するシナプス競合のメカニズム
@藤本 聡志, @今井 猛
医学のあゆみ 2023.7
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【生体イメージングの最前線-絶え間ない技術革新と生命医科学の新展開】イメージングで神経活動を解析する 発達期の樹状突起刈り込みを制御するシナプス競合のメカニズム
藤本 聡志, 今井 猛
医学のあゆみ 286 ( 5 ) 365 - 371 2023.7 （ ISSN:0039-2359 ）
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Automated neuronal reconstruction with super-multicolour fluorescence imaging
@Marcus N Leiwe, @Satoshi Fujimoto, #Toshikazu Baba, #Daichi Moriyasu, #Biswanath Saha, @Richi Sakaguchi, @Shigenori Inagaki, @Takeshi Imai
bioRxiv 2022.8
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BMPR-2 gates activity-dependent stabilization of dendrites during mitral cell remodeling
@Shuhei Aihara, @Satoshi Fujimoto, @Richi Sakaguchi, @Takeshi Imai
bioRxiv 2020.10
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Fujimoto S, Leiwe MN, Sakaguchi R, Muroyama Y, Kobayakawa R, Kobayakawa K, Saito T, Imai T
bioRxiv 2019.5
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透明化試薬SeeDB2を用いた深部高解像蛍光イメージング
@藤本聡志，@柯 孟岑，@坂口理智，@今井 猛
実験医学 2019.4
Industrial property rights
| Patent | Number of applications: 1 | Number of registrations: 0 |
| Utility model | Number of applications: 0 | Number of registrations: 0 |
| Design | Number of applications: 0 | Number of registrations: 0 |
| Trademark | Number of applications: 0 | Number of registrations: 0 |
Professional Memberships
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The Japanese Biochemical Society
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The Japan Neuroscience Society
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Society for Neuroscience
Research Projects
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Molecular basis for the "one mitral cell–one glomerulus" rule
Grant number：24K02132 2024 - 2026
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Principal investigator Grant type：Scientific research funding
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公益財団法人 ブレインサイエンス振興財団 第38回研究助成／生後発達期のシナプス競合を支える分子機構
2024
Grant type：Donation
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公益財団法人 金原一郎記念医学医療振興財団 第38回基礎医学医療研究助成金／発達期のシナプス競合を制御する分子基盤の解明
2023
Grant type：Donation
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公益財団法人 住友財団 2023年度 基礎科学研究助成／樹状突起の刈り込みを制御するシナプス競合の分⼦機構
2023
Grant type：Donation
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公益財団法人三共生命科学研究振興財団 2023年度研究助成／神経回路形成期のシナプス競合を制御する分子基盤
2023
Grant type：Donation
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Mechanisms of spontaneous activity-dependent synaptic competition in dendrite remodeling
Grant number：19K06886 2019 - 2022
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Fujimoto Satoshi
Authorship：Principal investigator Grant type：Scientific research funding
During development, neuronal activity plays an essential role in dendritic remodeling. However, the mechanism stabilizing synapses that receive a strong input and prunes the remaining synapses is poorly understood. A mechanism that determines "winners" and "losers" through synaptic competition has been postulated, but the mechanism is unknown. In this study, using mitral cells as a model, we show that an NMDA receptor-RhoA signaling-dependent local protection and lateral inhibition control synaptic competition and a general principle of neuronal receptive field formation.
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自発神経活動の脱同期による樹状突起の接続特異性決定機構
Grant number：17K14944 2017 - 2018
科学研究費助成事業 若手研究(B)
Authorship：Principal investigator Grant type：Scientific research funding
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自発発火のタイミングが決定する樹状突起の接続特異性
Grant number：15K14327 2015 - 2016
科学研究費助成事業 挑戦的萌芽研究
Authorship：Principal investigator Grant type：Scientific research funding
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新奇トランスシナプス遺伝子改変技術の開発
Grant number：24650175 2012 - 2013
科学研究費助成事業 挑戦的萌芽研究
Authorship：Principal investigator Grant type：Scientific research funding
Class subject
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人体構造と機能Ⅱ
2024.4 - 2024.9 First semester
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生理学実習
2023.10 - 2024.3 Second semester
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生体情報機能学Ⅱ
2023.10 - 2024.3 Second semester
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生体情報機能学Ⅱ
2022.10 - 2023.3 Second semester
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生理学実習
2022.10 - 2023.3 Second semester
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生体情報機能学Ⅱ
2021.10 - 2022.3 Second semester
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生理学実習
2021.10 - 2022.3 Second semester
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生体情報機能学Ⅱ
2020.10 - 2021.3 Second semester
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生理学実習
2020.10 - 2021.3 Second semester
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生体情報機能学Ⅱ-②
2019.10 - 2020.3 Second semester
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生理学実習
2019.10 - 2020.3 Second semester
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生体情報機能学Ⅱ-②
2018.10 - 2019.3 Second semester
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生理学実習
2018.10 - 2019.3 Second semester
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生理学実習
2017.10 - 2018.3 Second semester
FD Participation
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2022.12 Role：Participation Title：医学系学府教育ＦＤ「医学系大学院プログラムの進化と深化をめざして」
Organizer：[Undergraduate school/graduate school/graduate faculty]
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2022.8 Role：Participation Title：医学部医学科・生命科学科ＦＤ「医学教育分野別評価受審の振り返りについて」
Organizer：Undergraduate school department
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2022.2 Role：Participation Title：令和３年度馬出地区４部局合同男女共同参画FD
Organizer：[Undergraduate school/graduate school/graduate faculty]
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2021.12 Role：Participation Title：医学系学府教育ＦＤ「学術論文の購読と投稿とこれから」
Organizer：[Undergraduate school/graduate school/graduate faculty]
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2020.12 Role：Participation Title：医学系学府大学院ＦＤ「医学研究と倫理（２）」
Organizer：[Undergraduate school/graduate school/graduate faculty]
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2020.8 Role：Participation Title：【IDE大学セミナー】大学教職員の多様な働き方について
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2019.10 Role：Participation Title：馬出地区４部局合同男女共同参画FD
Organizer：[Undergraduate school/graduate school/graduate faculty]
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2017.10 Role：Participation Title：馬出地区キャンパスFD
Organizer：[Undergraduate school/graduate school/graduate faculty]
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2017.4 Role：Participation Title：全学FD（新任教員研修）
Organizer：University-wide