Updated on 2024/10/01

Information

 

写真a

 
KITAZONO TAKANARI
 
Organization
Faculty of Medical Sciences Center for Cohort Studies Professor
Faculty of Medical Sciences Center for Cohort Studies(Concurrent)
Kyushu University Hospital Department of Nephrology,Hypertension,and Strokology(Concurrent)
Kyushu University Hospital Department of Gastroenterology(Concurrent)
Kyushu University Hospital Kidney Care Unit(Concurrent)
School of Medicine Department of Medicine(Concurrent)
Graduate School of Medical Sciences Department of Medicine(Concurrent)
Graduate School of Medical Sciences Department of Medical Sciences(Concurrent)
Title
Professor
Tel
0926425250
Profile
[Research] We have established multi center registry systems of patients with stroke, diabetes, kidney disease, hypertension, and gastrointestinal diseases and are analyzing the data to clarify the pathogenesis, clinical course, outcomes and prognosis of these diseases. We are also doing basic research to investigate the detailed pathphysiological mechanisms.
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Degree

  • PhD

Research Interests・Research Keywords

  • Research theme:An epidemiological study of acute stroke patients, the Fukuoka Stroke Registry (FSR)

    Keyword:stroke, cohort study, epidemiology, database

    Research period: 2007.6

  • Research theme:Genomics of brain infarction

    Keyword:brain infarction, genomics, SNP

    Research period: 2005.4

  • Research theme:Molecular biology of CNS pericytes

    Keyword:cerebral microcirculation, pericyte

    Research period: 2004.4

  • Research theme:Study on cerebrovascular responses

    Keyword:responses of cerebral arteries, nitric oxide, potassium channels, hypertension

    Research period: 1991.9

Papers

  • Serum Ethylamine Levels as an Indicator of l-Theanine Consumption and the Risk of Type 2 Diabetes in a General Japanese Population: The Hisayama Study Reviewed International journal

    Ninomiya T, Kanzaki N, Hirakawa Y, Yoshinari M, Higashioka M, Honda T, Shibata M, Sakata S, Yoshida D, Teramoto T, Takemoto S, Nishimoto S, Hata J, Kitazono T.

    Diabetes Care.   2019.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Comparison of Prasugrel and Clopidogrel in Patients With Non-Cardioembolic Ischaemic Stroke: A Phase 3, Randomised, Non-Inferiority Trial (PRASTRO-I) Reviewed International journal

    Ogawa A, Toyoda K, Kitagawa K, Kitazono T, Nagao T, Yamagami H, Uchiyama S, Tanahashi N, Matsumoto M, Minematsu K, Nagata I, Nishikawa M, Nanto S, Abe K, Ikeda Y; PRASTRO-I Study Group.

    Lancet Neurol.   2019.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Nox4 Promotes Neural Stem/Precursor Cell Proliferation and Neurogenesis in the Hippocampus and Restores Memory Function Following Trimethyltin-Induced Injury Reviewed International journal

    Yoshikawa Y, Ago T, Kuroda J, Wakisaka Y, Tachibana M, Komori M, Shibahara T, Nakashima H, Nakashima K, Kitazono T.

    Neuroscience.   2019.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Impact of Body Weight Loss From Maximum Weight on Fragility Bone Fractures in Japanese Patients With Type 2 Diabetes: The Fukuoka Diabetes Registry. Reviewed International journal

    Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Sumi A, Yoshinari M, Nakamura U, Kang D, Kitazono T.

    Diabetes Care.   2018.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Insulin resistance and clinical outcomes after acute ischemic stroke. Reviewed International journal

    Ago T, Matsuo R, Hata J, Wakisaka Y, Kuroda J, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators.

    Neurology.   90 ( 17 )   e1470 - e1477   2018.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Association Between Onset-to-Door Time and Clinical Outcomes After Ischemic Stroke. Reviewed International journal

    Matsuo R, Yamaguchi Y, Matsushita T, Hata J, Kiyuna F, Fukuda K, Wakisaka Y, Kuroda J, Ago T, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators

    Stroke   48 ( 11 )   3049 - 3056   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Day-to-Day Blood Pressure Variability and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study. Reviewed International journal

    Oishi E, Ohara T, Sakata S, Fukuhara M, Hata J, Yoshida D, Shibata M, Ohtsubo T, Kitazono T, Kiyohara Y, Ninomiya T

    Circulation   136 ( 6 )   516 - 525   2017.8

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  • Early Reperfusion After Brain Ischemia Has Beneficial Effects Beyond Rescuing Neurons. Reviewed International journal

    Tachibana M, Ago T, Wakisaka Y, Kuroda J, Shijo M, Yoshikawa Y, Komori M, Nishimura A, Makihara N, Nakamura K, Kitazono T

    Stroke   48 ( 8 )   2222 - 2230   2017.8

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  • Downregulation of Endothelial Transient Receptor Potential Vanilloid Type 4 Channel and Small-Conductance of Ca2+-Activated K+ Channels Underpins Impaired Endothelium-Dependent Hyperpolarization in Hypertension. Reviewed International journal

    Seki T, Goto K, Kiyohara K, Kansui Y, Murakami N, Haga Y, Ohtsubo T, Matsumura K, Kitazono T

    Hypertension   69 ( 1 )   143 - 153   2017.1

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  • Short-Term Exposure to Fine Particulate Matter and Risk of Ischemic Stroke. Reviewed International journal

    Matsuo R, Michikawa T, Ueda K, Ago T, Nitta H, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators

    Stroke   47 ( 12 )   3032 - 3034   2016.12

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  • Renal denervation has blood pressure-independent protective effects on kidney and heart in a rat model of chronic kidney disease. Reviewed International journal

    Eriguchi M, Tsuruya K, Haruyama N, Yamada S, Tanaka S, Suehiro T, Noguchi H, Masutani K, Torisu K, Kitazono T

    Kidney Int   87   116 - 127   2015.1

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  • High blood pressure after acute ischemic stroke is associated with poor clinical outcomes: Fukuoka Stroke Registry. Reviewed International journal

    Ishitsuka K, Kamouchi M, Hata J, Fukuda K, Matsuo R, Kuroda J, Ago T, Kuwashiro T, Sugimori H, Nakane H, Kitazono T; FSR Investigators

    Hypertension   63   2014.1

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  • Intensity of anticoagulation and clinical outcomes in acute cardioembolic stroke: the Fukuoka Stroke Registry. Reviewed International journal

    Nakamura A, Ago T, Kamouchi M, Hata J, Matsuo R, Kuroda J, Kuwashiro T, Sugimori H, Kitazono T; Fukuoka Stroke Registry Investigators

    Stroke   44   2013.11

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  • Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009). Reviewed International journal

    Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y

    Circulation   128   2013.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders: results from the Hisayama Study. Reviewed International journal

    Nakano T, Ninomiya T, Sumiyoshi S, Onimaru M, Fujii H, Itabe H, Nakashima Y, Sueishi K, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y

    Kidey Int   84   2013.8

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  • Extracellular acidification activates cAMP responsive element binding protein via Na+/H+ exchanger isoform 1-mediated Ca2+ oscillation in central nervous system pericytes. Reviewed International journal

    Nakamura K, Kamouchi M, Arimura K, Nishimura A, Kuroda J, Ishitsuka K, Tokami H, Sugimori H, Ago T, Kitazono T

    Arterioscler Thromb Vasc Biol   32   2012.11

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  • Proteinuria and clinical outcomes after ischemic stroke. Reviewed International journal

    Kumai Y, Kamouchi M, Hata J, Ago T, Kitayama J, Nakane H, Sugimori H, Kitazono T, for the FSR Investigators

    Neurology   78   2012.6

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  • Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain. Reviewed International journal

    Shichita T, Hasegawa E, Kimura A, Morita R, Sakaguchi R, Takada I, Sekiya T, Ooboshi H, Kitazono T, Yanagawa T, Ishii T, Takahashi H, Mori S, Nishibori M, Kuroda K, Akira S, Miyake K, Yoshimura A

    Nat Med   18   2012.6

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    Language:English   Publishing type:Research paper (scientific journal)  

  • PDGF receptor β signaling in pericytes following ischemic brain injury. Reviewed International journal

    9   2012.2

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  • The antioxidant tempol ameliorates arterial medial calcification in uremic rats: important role of oxidative stress in the pathogenisis of vascular calcification in chronic kidney disease. Reviewed International journal

    Yamada S, Taniguchi M, Tokumoto M, Toyonaga J, Fujisaki K, Suehiro T, Noguchi H, Iida M, Tsuruya K, Kitazono T.

    J Bone Miner Res   27 ( 2 )   2012.2

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  • Prestroke glycemic control is associated with the functional outcome in acute ischemic stroke: the Fukuoka Stroke Registry. Reviewed International journal

    Kamouchi M, Matsuki T, Hata J, Kuwashiro T, Ago T, Sambongi Y, Fukushima Y, Sugimori H, Kitazono T; for the FSR investigators.

    Stroke   42   2011.10

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  • Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke. Reviewed International journal

    Matsushita T, Ashikawa K, Yonemoto K, Hirakawa Y, Hata J, Amitani H, Doi Y, Ninomiya T, Kitaozono T, Ibayashi S, Iida M, Nakamura Y, Kiyohara Y, Kubo M.

    Hum Mol Genet   19 ( 6 )   2010.3

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  • Role of NHE1 in calcium signaling and cell proliferation in human CNS pericytes Reviewed International journal

    Nakamura K, Kamouchi M, Kitazono T, Kuroda J, Matsuo R, Hagiwara N, Ishikawa E, Ooboshi H, Ibayashi S, Iida M

    American Journal of Physiology   2008.4

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  • NAD(P)H oxidase p22phox C242T polymorphism and ischemic stroke in Japan: the Fukuoka Stroke Registry and the Hisayama Study Reviewed International journal

    Kuroda J, Kitazono T, Ago T, Ninomiya T, Ooboshi H, Kamouchi M, Kumai Y, Hagiwara N, Yoshimura S, Tamaki K, Kusuda K, Fujii K, Nagao T, Okada Y, Toyoda K, Nakane H, Sugimori H, Yamashita Y, Wakugawa Y, Asano K, Tanizaki Y, Kiyohada Y, Ibayashi S, Iida M

    European Journal of Neurology   2007.10

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    Language:English   Publishing type:Research paper (scientific journal)  

  • A nonsynonymous SNP IN PRKCH (protein kinase Cη) increases the risk of cerebral infarction. Reviewed International journal

    39 ( 2 )   2007.2

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  • NAD(P)H oxidases in rat basilar arterial endothelial cells. Reviewed International journal

    Ago T, Kitazono T, Kuroda J, Kumai Y, Kamouchi M, Ooboshi H, Wakisaka M, Kawahara T, Rokutan K, Ibayashi S, Iida M.

    Stroke   36 ( 5 )   1040 - 1046   2005.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/01.STR.0000163111.05825.0b

  • NOX4 as the major catalytic component of an endothelial NAD(P)H oxidase. Reviewed International journal

    Ago, T., Kitazono, T., Ooboshi, H., Matsuo, R., Takada, J., Wakisaka, M., Ibayashi, S., Iida, M

    Circuration   109 ( 2 )   227 - 233   2004.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/01.CIR.0000105680.92873.70

  • Increased activity of calcium channels and Rho-associated kinase in the basilar artery during chronic hypertension in vivo. Reviewed International journal

    Kitazono, T., Ago, T., Kamouchi, M., Santa, N., Ooboshi, H., Fujishima, M., Ibayashi, S.

    Journal of Hypertension   20 ( 5 )   879 - 884   2002.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/00004872-200205000-00022

  • Sodium-coupled glucose transporter as a functional glucose sensor of retinal microvascular circulation. Reviewed International journal

    Wakisaka, M., Kitazono, T., Kato, M., Nakamura, U., Yoshioka, M., Uchizono, Y., Yoshinari, M.

    Circulation Research   88 ( 11 )   1183 - 1188   2001.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/hh1101.091265

  • Role of phosphatidylinositol 3-kinase in acetylcholine-induced dilatation of rat basilar artery in vivo. Reviewed International journal

    Kitayama, J., Kitazono, T., Ibayashi, S., Nagao, T., Wakisaka, M., Watanabe, Y., Fujishima, M.

    Stroke   31 ( 10 )   2487 - 2492   2000.1

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  • Role of tyrosine kinase in dilator responses of the basilar artery in vivo. Reviewed International journal

    Kitazono, T., Ibayashi, S., Nagao, T., Fujii, K., Kagiyama, T., Fujishima, M.

    Hypertension   31 ( 3 )   861 - 865   1998.1

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  • Dilatation of cerebral arterioles in response to activation of adenylate cyclase is dependent on activation of Ca2+-dependent K+ channels. Reviewed International journal

    Taguchi, H., Heistad, D.D., Kitazono, T., Faraci, F.M.

    Circulation Research   1995.1

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  • Evidence that angiotensin II is present in human monocytes. Reviewed International journal

    Kitazono, T., Padgett, R.C., Armstrong, M.L., Tompkins, P.K., Heistad, D.D.

    Circulation   1995.1

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  • Enhanced responses of the basilar artery to activation of endothelin B receptors in stroke-prone spontaneously hypertensive rats. Reviewed International journal

    Kitazono, T., Heistad, D.D., Faraci, F.M.

    Hypertension   1995.1

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  • Relaxation of the aorta during hypertension is impaired in chronically hypertensive rats. Reviewed International journal

    Taguchi, H., Faraci, F.M., Kitazono, T., Heistad, D.D.

    Hypertension   1995.1

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  • ATP-sensitive K+ channels mediate dilatation of cerebral arterioles during hypoxia. Reviewed International journal

    Taguchi H, Heistad DD, Kitazono T, Faraci FM

    Circulation Research   1994.1

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  • ATP-sensitive potassium channels in the basilar artery during chronic hypertension. Reviewed International journal

    Kitazono, T., Heistad, D.D., Faraci, F.M.

    Hypertension   1993.1

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  • Effect of norepinephrine on rat basilar artery in vivo. Reviewed International journal

    Kitazono, T., Faraci, F.M., Heistad, D.D.

    American Journal of Physiology   1993.1

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  • Role of ATP-sensitive K+ channels in CGRP-induced dilatation of the basilar artery in vivo. Reviewed International journal

    Kitazono, T., Heistad, D.D., Faraci, F.M.

    American Journal of Physiology   1993.1

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  • Intracellular pH changes of cultured bovine aortic endothelial cells in response to ATP addition. Reviewed International journal

    Kitazono, T., Takeshige, K., Cragoe, E.J., Jr., Minakami, S.

    Biochemical and Biophysical Research Communication   152 ( 3 )   1304 - 1309   1988.1

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    DOI: 10.1016/S0006-291X(88)80427-3

  • Blood Hemoglobin Concentrations and the Incidence of Lower Extremity Peripheral Arterial Disease in Patients Undergoing Hemodialysis: 10-Year Outcomes of the Q-Cohort Study

    Kohara C., Yamada S., Tanaka S., Hiyamuta H., Kitamura H., Arase H., Shimamoto S., Taniguchi M., Tsuruya K., Kitazono T., Nakano T.

    Journal of the American Heart Association   13 ( 15 )   e033853   2024.8

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    Language:English   Publisher:Journal of the American Heart Association  

    BACKGROUND: Lower extremity peripheral arterial disease is a potentially lethal cardiovascular complication in patients undergoing hemodialysis. Anemia is a risk factor for cardiovascular disease among the hemodialysis population. However, whether blood hemoglobin concentration is associated with the risk of peripheral arterial disease progression in this population remains undetermined. METHODS AND RESULTS: This is an extension of a 4-year multicenter, prospective, observational cohort study to 10 years. A total of 3504 Japanese patients undergoing maintenance hemodialysis were recruited between 2006 and 2007. The primary exposure was blood hemoglobin concentration at baseline. The main outcome was the first-ever incidence of major adverse limb events (MALE), composed of endovascular treatment, bypass surgery, and amputation. Multivariable-adjusted Cox proportional hazards model, Fine–Gray subdistribution hazards model, restricted cubic spline analysis, and restricted mean survival time analysis were used to determine the association of blood hemoglobin concentration with the incidence of MALE. During a median follow-up of 8.0 years, 257 patients experienced MALE. A Cox proportional hazards model showed that the risk of MALE in patients with blood hemoglobin concentrations <10.0 g/dL was significantly higher than in patients with concentrations of 11.0 to 11.9 g/dL, even after adjusting for confounding factors. In contrast, elevated hemoglobin concentration (≥12.0 g/ dL) was not significantly associated with increased risk of MALE. Similar associations were observed when the Fine–Gray subdistribution regression model was used by setting all-cause mortality as the competing risk. CONCLUSIONS: A low blood hemoglobin concentration is an independent risk factor for peripheral arterial disease progression in patients undergoing maintenance hemodialysis.

    DOI: 10.1161/JAHA.123.033853

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  • Association between Vascular Calcification and Intraplaque Hemorrhage in Coronary Atherosclerosis from Autopsy: The Hisayama Study

    Nakano Toshiaki, Kitamura Hiromasa, Hata Jun, Maki Kenji, Oda Yoshinao, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   31 ( 8 )   1225 - 1237   2024.8   ISSN:13403478 eISSN:18803873

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    Language:English   Publisher:Japan Atherosclerosis Society  

    <p> <b>Aims:</b> Vascular calcification is observed in advanced atherosclerotic lesions. Vascular calcification is considered to increase the risk of intraplaque hemorrhage and subsequent plaque destabilization; however, there is limited pathohistoological evidence of the association between vascular calcification and intraplaque hemorrhage. The aim of this study was to investigate the association between vascular calcification and intraplaque hemorrhage in the coronary arteries.</p><p> <b>Methods:</b> We examined 374 coronary arteries obtained from the autopsy samples of 126 deceased individuals. The vascular calcification levels of each artery were categorized into no calcification and quintiles of calcification area size among the arteries with calcification. Macrophage infiltration and neovascularization were also evaluated. The association of the calcification area, macrophage area, or number of vessels with the presence of intraplaque hemorrhage in the coronary arteries was estimated using a logistic regression analysis.</p><p><b>Results:</b> Calcification lesions were observed in 149 coronary arteries. Arteries in the fourth quintile of calcification area size had a significantly greater likelihood of intraplaque hemorrhage than the arteries without calcification, after adjusting for confounders: odds ratio 13.13 (95% confidence interval: 2.97–58.16). After evaluating the influence of macrophage infiltration, the highest odds ratio of intraplaque hemorrhage was associated with the combination of large macrophage area and moderately sized calicification areas. The odds ratio of intraplaque hemorrhage additively increased with the combination of calcification and the number of vessels.</p><p><b>Conclusions:</b> The present findings suggest that vascular calcification is significantly associated with intraplaque hemorrhage. The association between vascular calcification and intraplaque hemorrhage may decrease above a certain size of the calcification area.</p>

    DOI: 10.5551/jat.64394

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  • Association between Hemoglobin A1c and Renal Arteriolar Sclerosis in Subjects Presenting without any Apparent Kidney Dysfunction

    Matsukuma Yuta, Tsuchimoto Akihiro, Masutani Kosuke, Ueki Kenji, Tanaka Shigeru, Haruyama Naoki, Okabe Yasuhiro, Nakamura Masafumi, Kitazono Takanari, Nakano Toshiaki

    Journal of Atherosclerosis and Thrombosis   31 ( 8 )   1215 - 1224   2024.8   ISSN:13403478 eISSN:18803873

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    <p> <b>Aims:</b> Diabetic kidney disease is a major vascular complication in patients with diabetes mellitus (DM). However, the association between the hemoglobin (Hb)A1c levels, notably the prediabetic levels, and renal pathological changes remains unclear. We investigated the association between the HbA1c levels and renal arteriolar lesions in subjects without any apparent kidney dysfunction using a living kidney donor cohort.</p><p><b>Methods:</b> Between January 2006 and May 2016, 393 living kidney donors underwent a “zero-time” biopsy at Kyushu University Hospital. The patients were divided into four groups (HbA1c levels <5.6%, 5.6%–5.7%, 5.8%–6.4%, and ≥ 6.5%, or diagnosed with DM [DM group]). Renal arteriolar hyalinization and wall thickening were assessed using semi-quantitative grading. We then investigated the association between the HbA1c levels and renal pathological changes.</p><p><b>Results:</b> 158 (40.2%) patients had arteriolar hyalinization and 148 (37.6%) showed wall thickening. A significant correlation was observed between the HbA1c levels and wall thickening (<i>p</i> for trend <0.001). An elevated HbA1c level was significantly associated with wall thickening according to a multivariable logistic analysis in subjects with HbA1c levels of 5.6%–5.7% and 5.8%–6.4%, and the DM group, compared with those with HbA1c levels of <5.6% (odds ratio [OR], 1.91; 95% confidence interval [CI]: [1.03–3.54] for 5.6%–5.7%, OR, 1.96; 95% CI: [1.09–3.53] for 5.8%–6.4%, and OR, 2.86; 95% CI: [0.91–9.01] for the DM group), whereas arteriolar hyalinization did not increase within the nondiabetic HbA1c levels.</p><p><b>Conclusions:</b> Elevated high-normal HbA1c levels are considered to be independent risk factors for arteriolar wall thickening. Subclinical renal arteriolar sclerosis may develop in patients with prediabetic HbA1c levels.</p>

    DOI: 10.5551/jat.64236

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  • Arginase 2 attenuates ulcerative colitis by antioxidant effects of spermidine

    Imazu, N; Torisu, T; Yokote, A; Umeno, J; Kawasaki, K; Fujioka, S; Matsuno, Y; Nagasue, T; Kawatoko, S; Moriyama, T; Nitahata, T; Uchida, Y; Aihara, S; Taniguchi, Y; Oda, Y; Kitazono, T

    JOURNAL OF GASTROENTEROLOGY   59 ( 8 )   682 - 698   2024.8   ISSN:0944-1174 eISSN:1435-5922

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    Background: Spermidine suppress oxidative stress and is involved in various disease pathogenesis including ulcerative colitis (UC). Arginase 2 (ARG2) plays a central role in the synthesis of spermidine. This study aimed to clarify the effect of endogenously produced spermidine on colitis. Methods: The physiological role of ARG2 and spermidine was investigated using Arg2-deficient mice with reduced spermidine. Immunohistochemical staining of the rectum was used to analyze ARG2 expression and spermidine levels in healthy controls and UC patients. Results: In mice with dextran sulfate sodium-induced colitis, ARG2 and spermidine levels were increased in the rectal epithelium. Spermidine protects colonic epithelial cells from oxidative stress and Arg2 knockdown cells reduced antioxidant activity. Organoids cultured from the small intestine and colon of Arg2-deficient mice both were more susceptible to oxidative stress. Colitis was exacerbated in Arg2-deficient mice compared to wild-type mice. Supplementation with spermidine result in comparable severity of colitis in both wild-type and Arg2-deficient mice. In the active phase of UC, rectal ARG2 expression and spermidine accumulation were increased compared to remission. ARG2 and spermidine levels were similar in healthy controls and UC remission patients. Conclusions: ARG2 produces spermidine endogenously in the intestinal epithelium and has a palliative effect on ulcerative colitis. ARG2 and spermidine are potential novel therapeutic targets for UC.

    DOI: 10.1007/s00535-024-02104-z

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  • Association between glycated albumin and sudden death in patients undergoing hemodialysis

    Kaizu, Y; Nagata, M; Kaizu, S; Qie, YL; Kaizu, K; Tanaka, S; Nakano, T; Kitazono, T

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   28 ( 7 )   656 - 663   2024.7   ISSN:1342-1751 eISSN:1437-7799

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    Language:English   Publisher:Clinical and Experimental Nephrology  

    Background: The frequency of sudden death and its risk factors in patients undergoing hemodialysis are unknown. This study was performed to examine the association between glycated albumin (GA) and sudden death in Japanese patients undergoing hemodialysis. Methods: In total, 260 patients undergoing hemodialysis aged ≥18 years were retrospectively followed for a mean of 4.6 years. The patients’ serum GA levels were divided into tertiles, and the patients’ sex, age, albumin level, C-reactive protein (CRP) level, and cardiothoracic ratio (CTR) were selected as adjustment factors. A logistic regression model was used to calculate the odds ratio (OR) for the occurrence of sudden death by GA level. Results: Ninety-one patients died during follow-up. Of the 91 deaths, 23 (25.2%) were defined as sudden deaths. Compared with non-sudden death cases, sudden death cases were significantly younger (p = 0.002) and had a higher proportion of men (p = 0.03), a higher proportion of diabetes (p = 0.008), and higher GA levels (p = 0.023). Compared with patients with the lowest GA levels (<15.2%), those with the highest GA levels (≥18.5%) had a sex- and age-adjusted OR for sudden death of 5.40 [95% confidence interval (CI): 1.35–21.85]. After adjusting for the albumin level, CRP level, and CTR in addition to sex and age, the OR for sudden death of patients with the highest GA levels increased to 6.80 (95%CI: 1.64–28.08); the relationship did not change. Conclusion: Serum GA levels were significantly associated with sudden death in patients undergoing hemodialysis.

    DOI: 10.1007/s10157-024-02475-w

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  • Association between retinopathy and risk of dementia in a general Japanese population: the Hisayama Study

    Nakamura, S; Ueda, E; Ohara, T; Hata, J; Honda, T; Fujiwara, K; Furuta, Y; Shibata, M; Hashimoto, S; Nakazawa, T; Nakao, T; Kitazono, T; Sonoda, KH; Ninomiya, T

    SCIENTIFIC REPORTS   14 ( 1 )   12017   2024.5   ISSN:2045-2322

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    We investigated the association of retinopathy with the risk of dementia in a general older Japanese population. A total of 1709 population-based residents aged 60 years or older without dementia were followed prospectively for 10 years (2007–2017). They underwent color fundus photography in 2007. Retinopathy was graded according to the Modified Airlie House Classification. Main outcome was the Incidence of dementia. A Cox proportional hazards model was used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) for the risk of dementia by the presence of retinopathy. During the follow-up period, 374 participants developed all-cause dementia. The cumulative incidence of dementia was significantly higher in those with retinopathy than those without (p < 0.05). Individuals with retinopathy had significantly higher risk of developing dementia than those without after adjustment for potential confounding factors (HR 1.64, 95% CI 1.19–2.25). Regarding the components of retinopathy, the presence of microaneurysms was significantly associated with a higher multivariable-adjusted HR for incident dementia (HR 1.94, 95% CI 1.37–2.74). Our findings suggest that, in addition to systemic risk factors, retinal microvascular signs from fundus photography provide valuable information for estimating the risk of developing dementia.

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  • Association Between Serum NT-proBNP and Gray Matter Atrophy Patterns in an Older Japanese Population: The Hisayama Study

    Hirabayashi, N; Hata, J; Furuta, Y; Nakazawa, T; Ohara, T; Shibata, M; Yamashita, F; Kitazono, T; Sudo, N; Ninomiya, T

    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES   79 ( 5 )   2024.5   ISSN:1079-5006 eISSN:1758-535X

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    Several population-based studies have reported that higher serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels are associated with brain morphological changes. However, no population-based studies have examined the relationship between serum NT-proBNP and various regional brain volumes in detail. We here analyzed the brain MRI data of 1 201 community-dwelling Japanese aged =65 years. Regional gray matter volumes (GMV) and intracranial volume (ICV) were estimated by applying voxel-based morphometry (VBM) methods. The associations of serum NT-proBNP with regional GMV/ICV were examined by analysis of covariance. The regional gray matter atrophy patterns associated with elevated serum NT-proBNP levels were investigated using VBM without a priori regions of interest. The multivariable-adjusted means of the frontal, temporal, hippocampal, parahippocampal, and entorhinal GMV/ICV decreased significantly with elevated serum NT-proBNP levels (all p for trend and q values of false discovery rate correction < .05). In VBM, elevated serum NT-proBNP levels were correlated with atrophy of the bilateral hippocampi, bilateral amygdalas, bilateral parahippocampal gyri, bilateral entorhinal areas, bilateral fusiform gyri, left middle temporal gyrus, left inferior temporal gyrus, right central operculum, right posterior orbital gyrus, bilateral middle frontal gyri, anterior cingulate gyrus and bilateral medial frontal cortices. In a sensitivity analysis excluding 254 participants with mild cognitive impairment or dementia, serum NT-proBNP levels were correlated with atrophy of the bilateral hippocampi, bilateral amygdalas, bilateral parahippocampal gyri, bilateral fusiform gyri, and left middle frontal gyrus. Our data suggest that elevated serum NT-proBNP levels are associated with gray matter atrophy in brain regions that play an important role in cognitive function.

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  • A simple score for malnutrition-inflammation complex syndrome (MICS) is associated with the risk of mortality in Japanese patients undergoing maintenance hemodialysis

    Yamada, S; Arase, H; Taniguchi, M; Kitazono, T; Nakano, T

    THERAPEUTIC APHERESIS AND DIALYSIS   28 ( 2 )   206 - 217   2024.4   ISSN:1744-9979 eISSN:1744-9987

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    Introduction: Malnutrition–inflammation complex syndrome (MICS) is highly prevalent in patients undergoing hemodialysis. We determined the prognostic value of the Simple MICS score, calculated using a combination of age, body mass index, and serum concentrations of albumin, creatinine, and C-reactive protein. Methods: We retrospectively recruited 218 Japanese patients undergoing maintenance hemodialysis. The primary outcome was all-cause mortality, and the main exposure was the Simple MICS score. Cox proportional hazard regression analysis and logistic regression analysis were used to characterize the relationship between the Simple MICS score and mortality. Results: During a median 4.4-year follow-up period, 56 patients died. Multivariable-adjusted models showed that a higher Simple MICS score was associated with higher risks of mortality. The predictability for all-cause mortality of the Simple MICS score was significantly better than conventional nutrition-related indices. Conclusion: The Simple MICS score can be used to stratify mortality risk in patients undergoing maintenance hemodialysis.

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  • Impact of Electrocardiographic Parameters on Sudden Death in Patients Receiving Maintenance Hemodialysis: Ten-Year Outcomes of the Q-Cohort Study Reviewed International journal

    Hiyamuta H, Yamada S, Nakano T, Taniguchi M, Masutani K, Tsuruya K, Kitazono T

    J Atheroscler Thromb   2024.3

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  • History of fragility fracture is associated with cardiovascular mortality in hemodialysis patients: the Q-Cohort study Reviewed International journal

    Haruyama N, Nakayama M, Yamada S, Tanaka S, Hiyamuta H, Taniguchi M, Tokumoto M, Tsuruya K, Kitazono T, Nakano T

    J Bone Miner Metab   2024.3

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  • Longitudinal association of sedentary time with diabetes mellitus and markers of glucose metabolism in middle-aged and older adults: The Hisayama Study Reviewed International journal

    Tsuda S, Honda T, Higashioka M, Hata J, Nakano T, Kitazono T, Ninomiya T

    J Diabetes Investig   2024.2

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  • Association between abdominal adiposity and clinical outcomes in patients with acute ischemic stroke

    Wakisaka, K; Matsuo, R; Irie, F; Wakisaka, Y; Ago, T; Kamouchi, M; Kitazono, T

    PLOS ONE   19 ( 1 )   e0296833   2024.1   ISSN:1932-6203

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    Background It is unclear whether abdominal adiposity has an additional effect on post-stroke outcomes. This study aimed to determine whether waist circumference (WC) is independently associated with clinical outcomes after acute ischemic stroke. Methods We enrolled patients with acute ischemic stroke from a multicenter hospital-based stroke registry in Fukuoka, Japan. We measured WC on admission and categorized patients into four groups (Q1–Q4) according to the quartiles in females and males. The clinical outcomes were poor functional outcome (modified Rankin scale score 2–6) and death from any cause. Logistic regression analysis was performed to estimate the odds ratio and 95% confidence interval of the outcomes of interest after adjusting for potential confounding factors, including body mass index (BMI). Results A total of 11,989 patients (70.3±12.2 years, females: 36.1%) were included in the analysis. The risk of poor functional outcome significantly decreased for Q2–Q4 (vs. Q1) at discharge and Q2–Q3 (vs. Q1) at 3 months, even after adjusting for potential confounders, including BMI. In contrast, adjustment of BMI eliminated the significant association between WC and all-cause death at discharge and 3 months. The association between high WC and favorable functional outcome was not affected by fasting insulin levels or homeostatic model assessment for insulin resistance and was only found in patients without diabetes (P = 0.02 for heterogeneity). Conclusions These findings suggest that abdominal adiposity has an additional impact on post-stroke functional outcome, independent of body weight and insulin action.

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  • Body temperature in the acute phase and clinical outcomes after acute ischemic stroke

    Mezuki, S; Matsuo, R; Irie, F; Shono, Y; Kuwashiro, T; Sugimori, H; Wakisaka, Y; Ago, T; Kamouchi, M; Kitazono, T

    PLOS ONE   19 ( 1 )   e0296639   2024.1   ISSN:1932-6203

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    Background This study aimed to examine whether post-stroke early body temperature is associated with neurological damage in the acute phase and functional outcomes at three months. Methods We included 7,177 patients with acute ischemic stroke within 24 h of onset. Axillary temperature was measured daily in the morning for seven days. Mean body temperature was grouped into five quintiles (Q1: 35.1–36.5◦C, Q2: 36.5–36.7◦C, Q3: 36.7–36.8◦C, Q4: 36.8–37.1◦C, and Q5: 37.1–39.1◦C). Clinical outcomes included neurological improvement during hospitalization and poor functional outcome (modified Rankin scale score, 3–6) at three months. A logistic regression analysis was performed to evaluate the association between body temperature and clinical outcomes. Results The patient’s mean (SD) age was 70.6 (12.3) years, and 35.7% of patients were women. Mean body temperature was significantly associated with less neurological improvement from Q2 (odds ratios [95% confidence interval], 0.77 [0.65–0.99] vs. Q1) to Q5 (0.33 [0.28–0.40], P for trend <0.001) even after adjusting for potential confounders, including baseline neurological severity, C-reactive protein levels, and post-stroke acute infections. The multivariable-adjusted risk of poor functional outcome linearly increased from Q2 (1.36 [1.03–1.79]) to Q5 (6.44 [5.19–8.96], P for trend <0.001). These associations were maintained even in the analyses excluding patients with acute infectious diseases. Multivariable-adjusted risk of poor functional outcome was higher in patients with early body temperature elevation on days 1–3 and with longer duration with body temperature >37.0◦C. Conclusions Post-stroke early high body temperature is independently associated with unfavorable outcomes following acute ischemic stroke.

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  • Serum Lipopolysaccharide-binding Protein Levels and the Incidence of Metabolic Syndrome in a General Japanese Population: the Hisayama Study Reviewed International journal

    Tomooka S, Oishi E, Asada M, Sakata S, Hata J, Chen S, Honda T, Suzuki K, Watanabe H, Murayama N, Wada N, Kitazono T, Ninomiya T

    J Epidemiol   2024.1

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  • Reply to "Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis" Reviewed International journal

    Yokote A, Imazu N, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Moriyama T, Miyawaki K, Akashi K, Kitazono T, Torisu T

    J Gastroenterol   2024.1

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  • Ustekinumab Decreases Circulating Th17 Cells in Ulcerative Colitis Reviewed International journal

    Imazu N, Torisu T, Ihara Y, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Moriyama T, Kitazono T

    Intern Med   2024.1

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  • Associations between the Serum Triglyceride Level and Kidney Outcome in Patients with Chronic Kidney Disease: The Fukuoka Kidney disease Registry Study

    Seki Mai, Nakano Toshiaki, Tanaka Shigeru, Kitamura Hiromasa, Hiyamuta Hiroto, Ninomiya Toshiharu, Tsuruya Kazuhiko, Kitazono Takanari

    Journal of Atherosclerosis and Thrombosis   advpub ( 0 )   2024   ISSN:13403478 eISSN:18803873

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    <p> <b>Aims:</b> Hypertriglyceridemia is a risk factor for chronic kidney disease (CKD). However, whether or not it predicts the risk of CKD progression is unknown. This study evaluated the association between serum triglyceride (TG) levels and kidney disease progression in patients with non-dialysis-dependent CKD.</p><p><b>Methods:</b> The Fukuoka Kidney disease Registry (FKR) study was a multicenter, prospective longitudinal cohort study. In total, 4,100 patients with CKD were followed up for 5 years. The primary outcome was the incidence of CKD progression, defined as a ≥ 1.5-fold increase in serum creatinine level or the development of end-stage kidney disease. The patients were divided into quartiles according to baseline serum TG levels under non-fasting conditions: Q1 <87 mg/dL; Q2, 87–120 mg/dL; Q3, 121–170 mg/dL, and Q4 >170 mg/dL.</p><p><b>Results:</b> During the 5-year observation period, 1,410 patients met the criteria for CKD progression. The multivariable-adjusted Cox proportional hazards model showed a significant association between high serum TG level and the risk of CKD progression in the model without macroalbuminuria as a covariate (multivariable hazard ratio[HR] for Q4 versus Q1, 1.20; 95% CI, 1.03–1.41; <i>P</i>=0.022), but the significance disappeared after adjusting for macroalbuminuria (HR for Q4 versus Q1, 1.06; 95% CI, 0.90–1.24; <i>P</i>=0.507).</p><p><b>Conclusions:</b> The present findings suggest that individuals with high serum TG levels are more likely to develop CKD progression than those without; however, whether or not higher serum TG levels reflect elevated macroalbuminuria or lead to CKD progression via elevated macroalbuminuria is unclear.</p>

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  • Association of sarcopenia with regional brain atrophy and white matter lesions in a general older population: the Hisayama Study

    Tajimi T., Hirabayashi N., Furuta Y., Nakazawa T., Honda T., Hata J., Ohara T., Shibata M., Kitazono T., Nakashima Y., Ninomiya T.

    GeroScience   2024   ISSN:25092715

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    Sarcopenia has been reported to be associated with cognitive decline and the risk of dementia. However, few studies have addressed the association between sarcopenia and brain morphological changes in the general population. A total of 1373 community-dwelling participants aged ≥ 65 years underwent brain MRI. Sarcopenia was defined based on the Asian Working Group for Sarcopenia's criteria. The pattern of regional gray matter volume loss associated with sarcopenia were assessed using a voxel-based morphometry (VBM) analysis. Regional brain volumes, intracranial volumes (ICV), and white matter lesions volumes (WMLV) were also measured using FreeSurfer. An analysis of covariance was used to examine the associations of sarcopenia with regional brain volumes in proportion to ICV. Of the participants, 112 had sarcopenia. The participants with sarcopenia had significantly lower total brain volume/ICV and total gray matter volume/ICV and higher WMLV/ICV than those without sarcopenia after adjusting for confounders. In VBM, sarcopenia was associated with lower gray matter volume in the frontal lobe, insula, cingulate gyrus, hippocampus, amygdala, and basal ganglia. Using FreeSurfer, we confirmed that the participants with sarcopenia had significantly lower frontal, insular, cingulate, and hippocampal volumes than those without sarcopenia. The current study showed that participants with sarcopenia had significantly lower volume in the frontal lobe, insula, cingulate, and hippocampus and higher WMLV than participants without sarcopenia. As these brain regions are likely to play an important role in cognitive function, these changes may suggest a shared underlying mechanism for the progression of sarcopenia and cognitive decline.

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  • Clinical Features of Gastroduodenal Ulcers in Kidney Transplant Patients Reviewed International journal

    Kondo M, Torisu T, Ihara Y, Kawasaki K, Umeno J, Kawatoko S, Tsuchimoto A, Nakano T, Okabe Y, Kitazono T

    Intern Med   2023.12

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  • Risks of dementia in a general Japanese older population with preserved ratio impaired spirometry: The Hisayama Study Reviewed International journal

    Kawatoko K, Washio Y, Ohara T, Fukuyama S, Honda T, Hata J, Nakazawa T, Kan-O K, Inoue H, Matsumoto K, Nakao T, Kitazono T, Okamoto I, Ninomiya T

    J Epidemiol   2023.12

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  • More rapid progression of brain atrophy in patients on peritoneal dialysis compared with hemodialysis: The VCOHP Study Reviewed International journal

    Tsuruya K, Yoshida H, Yamada S, Haruyama N, Tanaka S, Tsuchimoto A, Eriguchi M, Fujisaki K, Torisu K, Nakano T, Masutani K, Kitazono T

    Hypertens Res   2023.12

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  • FLAIR hyperintense cortical lesions in anti-myelin oligodendrocyte glycoprotein antibody-associated encephalitis with seizure following SARS-CoV-2 mRNA vaccination Reviewed International journal

    Yoshino F, Ozaki Y, Shibahara T, Matsuoka M, Tachibana M, Ago T, Kitazono T, Kuroda J, Nakane H

    eNeurologicalSci   2023.12

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  • Prevalence of hyponatremia and associated factors in patients with chronic kidney disease: the Fukuoka Kidney Disease Registry (FKR) study Reviewed International journal

    Inoue M, Nakai K, Tanaka S, Mitsuiki K, Tokumoto M, Tsuruya K, Kitazono T, Nakano T

    Clin Exp Nephrol   2023.12

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  • Development and Validation of a Risk Prediction Model for Atherosclerotic Cardiovascular Disease in Japanese Adults: The Hisayama Study Reviewed International journal

    Honda T, Chen S, Hata J, Yoshida D, Hirakawa Y, Furuta Y, Shibata M, Sakata S, Kitazono T, Ninomiya T

    J Atheroscler Thromb   2023.12

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  • Disease Flares Following COVID-19 Vaccination in Patients with Inflammatory Bowel Disease Reviewed International journal

    Yoshida Y, Fujioka S, Moriyama T, Umeno J, Kawasaki K, Fuyuno Y, Matsuno Y, Ihara Y, Torisu T, Kitazono T

    Intern Med   2023.12

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  • Effectiveness and safety of reduced-dose rivaroxaban for elderly patients with non-valvular atrial fibrillation: A subanalysis of the EXPAND study Reviewed International journal

    Shimizu W, Uchiyama S, Atarashi H, Inoue H, Kitazono T, Yamashita T, Ikeda T, Kamouchi M, Kaikita K, Fukuda K, Origasa H, Shimokawa H

    Int J Cardiol   2023.11

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  • Cumulative smoking dose is associated with subclinical renal injury: a pathological study in individuals without chronic kidney disease Reviewed International journal

    Ataka E, Matsukuma Y, Ueki K, Tsuchimoto A, Okabe Y, Masutani K, Nakamura M, Nakano T, Kitazono T

    Nephrol Dial Transplant   2023.11

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  • Angiotensin II receptor blockers and bone fracture in chronic kidney disease patients: the Fukuoka kidney disease Registry Study Reviewed International journal

    Shukuri T, Nakai K, Tanaka S, Yamada S, Tokumoto M, Tsuruya K, Nakano T, Kitazono T

    Clin Exp Nephrol   2023.11

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  • Angiotensin II receptor blockers and bone fracture in chronic kidney disease patients: the Fukuoka kidney disease Registry Study

    Shukuri, T; Nakai, K; Tanaka, S; Yamada, S; Tokumoto, M; Tsuruya, K; Nakano, T; Kitazono, T

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   27 ( 11 )   919 - 927   2023.11   ISSN:1342-1751 eISSN:1437-7799

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    Background: Angiotensin II receptor blockers (ARBs) reportedly reduce the risk of developing bone fractures; however, this association remains unclear among patients with chronic kidney disease (CKD). Methods: This was a cross-sectional study of 3380 CKD patients enrolled in the Fukuoka Kidney disease Registry Study, a multicenter prospective observational cohort study of non-dialysis-dependent CKD patients. The patients were divided into two groups, those taking ARBs and those who were not. Logistic regression models were used to examine the association between ARBs and bone fracture. Results: Approximately 67.0% of the participants were on ARBs, and 6.3% had a history of bone fracture. The history of bone fracture was significantly lower in patients with prescribed ARB and remained significant even after multivariable adjustment (odds ratio, 0.68; 95% confidence interval, 0.51–0.93). Other antihypertensive drugs, such as thiazide diuretics, which were reportedly helpful in preventing fractures, did not alter the bone fracture history and did not change among ARB users and non-users. Conclusions: The present study showed that administering ARB was significantly associated with a lower frequency of bone fracture history.

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  • Association between iron status markers and kidney outcome in patients with chronic kidney disease

    Fujisawa, H; Nakayama, M; Haruyama, N; Fukui, A; Yoshitomi, R; Tsuruya, K; Nakano, T; Kitazono, T

    SCIENTIFIC REPORTS   13 ( 1 )   18278   2023.10   ISSN:2045-2322

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    Several studies conducted in patients with various stages of chronic kidney disease (CKD) have investigated the association of iron status markers, such as transferrin saturation (TSAT) and serum ferritin, with kidney outcomes. However, the associations were inconsistent and remain strongly debated. Therefore, we aimed to investigate whether TSAT and serum ferritin levels were associated with kidney outcome in such a population. In this study, 890 patients who were admitted for the evaluation of and education for CKD were prospectively followed. Primary kidney outcome was a composite of doubling of serum creatinine, end-stage kidney disease, or death due to kidney failure. Participants were divided into quartiles (Q1–Q4) according to TSAT or serum ferritin levels. During a median follow-up period of 2.8 years, kidney events occurred in 358 patients. In the multivariable Cox analyses, compared with Q3 of TSAT, the hazard ratios (95% confidence intervals) for Q1, Q2, and Q4 were 1.20 (0.87, 1.66), 1.38 (1.01, 1.87), and 1.14 (0.82, 1.59), respectively. Compared with Q2 of serum ferritin, lower and higher quartiles had a significantly increased risk for kidney outcome; hazard ratios (95% confidence intervals) for Q1, Q3, and Q4 were 1.64 (1.18, 2.27), 1.71 (1.24, 2.37), and 1.52 (1.10, 2.10), respectively. A Fine-Gray model with death before kidney events as a competing risk showed results similar to the above. In CKD, lower and higher ferritin levels were independent risk factors for kidney disease progression.

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  • Characteristics and outcomes of unknown onset stroke: The Japan Stroke Data Bank

    Wada, S; Yoshimura, S; Toyoda, K; Nakai, M; Sasahara, Y; Miwa, K; Koge, J; Ishigami, A; Shiozawa, M; Ogasawara, K; Kitazono, T; Nogawa, S; Iwanaga, Y; Miyamoto, Y; Minematsu, K; Koga, M

    JOURNAL OF THE NEUROLOGICAL SCIENCES   453   120798   2023.10   ISSN:0022-510X eISSN:1878-5883

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    Background: Clinical outcomes of unknown onset stroke (UOS) are influenced by the enlargement of the therapeutic time window for reperfusion therapy. This study aimed to investigate and describe the characteristics and clinical outcomes of patients with UOS. Methods: Patients with acute ischemic stroke (AIS) who were admitted within 24 h of their last known well time, from January 2017 to December 2020, were included. Data were obtained from a long-lasting nationwide hospital-based multicenter prospective registry: the Japan Stroke Data Bank. The co-primary outcomes were the National Institutes of Stroke Scale (NIHSS) scores on admission and unfavorable outcomes at discharge, corresponding to modified Rankin Scale (mRS) scores of 3–6. Results: Overall, 26,976 patients with AIS were investigated. Patients with UOS (N = 5783, 78 ± 12 years of age) were older than patients with known onset stroke (KOS) (N = 21,193, 75 ± 13 years of age). Age, female sex, higher premorbid mRS scores, atrial fibrillation, and congestive heart failure were associated with UOS in multivariate analysis. UOS was associated with higher NIHSS scores (median = 8 [interquartile range [IQR]: 3–19] vs. 4 [1–10], adjusted incidence rate ratio = 1.37 [95% CI: 1.35–1.38]) and unfavorable outcomes (52.1 vs. 33.6%, adjusted odds ratio = 1.27 [1.14–1.40]). Intergroup differences in unfavorable outcomes were attenuated among females (1.12 [0.95–1.32] vs. males 1.38 [1.21–1.56], P = 0.040) and in the subgroup that received reperfusion therapy (1.10 [0.92–1.33] vs. those who did not receive therapy 1.23 [1.08–1.39], P = 0.012). Conclusions: UOS was associated with unfavorable outcomes but to a lesser degree among females and patients receiving reperfusion therapy.

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  • HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis Reviewed International journal

    Gastroenterology   2023.10

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  • Association between iron status markers and kidney outcome in patients with chronic kidney disease Reviewed International journal

    Fujisawa H, Nakayama M, Haruyama N, Fukui A, Yoshitomi R, Tsuruya K, Nakano T, Kitazono T

    Sci Rep   2023.10

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  • Characteristics and outcomes of unknown onset stroke: The Japan Stroke Data Bank Reviewed International journal

    Wada S, Yoshimura S, Toyoda K, Nakai M, Sasahara Y, Miwa K, Koge J, Ishigami A, Shiozawa M, Ogasawara K, Kitazono T, Nogawa S, Iwanaga Y, Miyamoto Y, Minematsu K, Koga M; Japan Stroke Data Bank Investigators

    J Neurol Sci   2023.10

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  • Arginase 2 Promotes Cisplatin-Induced Acute Kidney Injury by the Inflammatory Response of Macrophages Reviewed International journal

    Uchida Y, Torisu K, Aihara S, Imazu N, Ooboshi H, Kitazono T, Nakano T

    Lab Invest   2023.10

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  • Immunological analysis of hybrid neoantigen peptide encompassing class I/II neoepitope-pulsed dendritic cell vaccine Reviewed International journal

    Morisaki S, Onishi H, Morisaki T, Kubo M, Umebayashi M, Tanaka H, Koya N, Nakagawa S, Tsujimura K, Yoshimura S, Yew PY, Kiyotani K, Nakamura Y, Nakamura M, Kitazono T, Morisaki T

    Front Immunol   2023.10

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  • Arginase 2 Promotes Cisplatin-Induced Acute Kidney Injury by the Inflammatory Response of Macrophages

    Uchida, Y; Torisu, K; Aihara, S; Imazu, N; Ooboshi, H; Kitazono, T; Nakano, T

    LABORATORY INVESTIGATION   103 ( 10 )   100227   2023.10   ISSN:0023-6837 eISSN:1530-0307

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    Acute kidney injury (AKI) is a complex clinical syndrome with a rapid decrease in renal function caused by several different etiologies, including sepsis, ischemia, and the administration of nephrotoxic drugs. Tubular arginase 2 (ARG2), an arginine-metabolic enzyme, is a potential therapeutic target for AKI, but it has not been confirmed under various AKI conditions. The aim of this study was to investigate ARG2 as a therapeutic target for cisplatin-induced AKI. Cisplatin-treated mice with a genetic deficiency in Arg2 had significant amelioration of renal dysfunction, characterized by decreased acute tubular damage and apoptosis. In contrast, cisplatin-induced tubular toxicity was not ameliorated in proximal tubule cells derived from Arg2-deficient mice. Immunohistochemical analysis demonstrated the increased infiltration of ARG2-positive macrophages in kidneys damaged by cisplatin. Importantly, cisplatin-treated Arg2 knockout mice exhibited a significant reduction in kidney inflammation, characterized by the decreased infiltration of inflammatory macrophages and reduced gene expression of interleukin (IL)-6 and IL-1β. The secretion of IL-6 and IL-1β induced by lipopolysaccharides was decreased in bone marrow–derived macrophages isolated from Arg2-deficient mice. Furthermore, the lipopolysaccharide-induced elevation of mitochondrial membrane potential and production of reactive oxygen species were reduced in bone marrow–derived macrophages lacking Arg2. These findings indicate that ARG2 promotes the inflammatory responses of macrophages through mitochondrial reactive oxygen species, resulting in the exacerbation of AKI. Therefore, targeting ARG2 in macrophages may constitute a promising therapeutic approach for AKI.

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  • Cardiovascular Risk Factor Burden and Treatment Control in Patients with Chronic Kidney Disease: A Cross-Sectional Study Reviewed International journal

    Kitamura H, Tanaka S, Hiyamuta H, Shimamoto S, Tsuruya K, Nakano T, Kitazono T

    J Atheroscler Thromb   2023.9

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  • Magnesium inhibits peritoneal calcification as a late-stage characteristic of encapsulating peritoneal sclerosis Reviewed International journal

    Aihara S, Yamada S, Matsueda S, Nagashima A, Torisu K, Kitazono T, Nakano T

    Sci Rep   2023.9

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  • Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis Reviewed International journal

    Yokote A, Imazu N, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Moriyama T, Miyawaki K, Akashi K, Kitazono T, Torisu T

    J Gastroenterol   2023.9

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  • Association between Serum C-Reactive Protein Concentrations and Risk of Cancer-Related Mortality in Patients Undergoing Hemodialysis: 10-Year Outcomes of the Q-Cohort Study

    Uchida, Y; Nakano, T; Hiyamuta, H; Kitamura, H; Taniguchi, M; Ooboshi, H; Tsuruya, K; Kitazono, T

    BLOOD PURIFICATION   52 ( 7-8 )   694 - 701   2023.9   ISSN:0253-5068 eISSN:1421-9735

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    Cancer constitutes a major source of morbidity and mortality among people undergoing hemodialysis (HD). A systemic inflammatory response is associated with the incidence and prognosis of cancer in the general population. However, the effect of systemic inflammation on cancer-related mortality in patients undergoing HD remains unclear. Methods: We analyzed 3,139 patients registered in the Q-Cohort Study, which is a multicenter, observational cohort study of patients on hemodialysis in Japan. The primary outcome was cancer-related mortality during a 10-year follow-up. The covariate of interest was serum C-reactive protein (CRP) concentrations at baseline. The patients were divided into tertiles based on their serum CRP concentrations at baseline (tertile [T] 1: ≤0.07; T2: 0.08-0.24; and T3: ≥0.25). The association between serum CRP concentrations and cancer-related mortality was calculated using the Cox proportional hazards model and the Fine-Gray subdistribution hazards model with non-cancer-related death as a competing risk. Results: During the 10-year follow-up, 216 patients died of cancer. In the multivariable analysis, the risk of cancer-related mortality in the highest tertile (T3) of serum CRP concentrations was significantly higher than that in the lowest tertile (T1) (multivariable-adjusted hazard ratio [95% confidence interval]: 1.68 [1.15-2.44]). This association remained consistent in the competing risk model, in which the subdistribution hazard ratio was 1.47 and the 95% confidence interval was 1.00-2.14 for T3 compared with T1. Conclusion: Higher serum CRP concentrations are associated with an increased risk of cancer-related mortality in patients undergoing maintenance HD.

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  • Sex differences in the association between urate metabolism and kidney outcomes in patients with chronic kidney disease Reviewed International journal

    Haruyama N, Nakayama M, Fukui A, Yoshitomi R, Tsuruya K, Nakano T, Kitazono T

    Clin Exp Nephrol   2023.8

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  • Acrolein produced during acute kidney injury promotes tubular cell death

    Aihara, S; Torisu, K; Hirashima, Y; Kitazono, T; Nakano, T

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   666   137 - 145   2023.7   ISSN:0006-291X eISSN:1090-2104

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    Acute kidney injury is an important global health concern as it is associated with high morbidity and mortality. Polyamines, essential for cell growth and proliferation, are known to inhibit cardiovascular disease. However, under conditions of cellular damage, toxic acrolein is produced from polyamines by the enzyme spermine oxidase (SMOX). We used a mouse renal ischemia-reperfusion model and human proximal tubule cells (HK-2) to investigate whether acrolein exacerbates acute kidney injury by renal tubular cell death. Acrolein visualized by acroleinRED was increased in ischemia-reperfusion kidneys, particularly in tubular cells. When HK-2 cells were cultured under 1% oxygen for 24 h, then switched to 21% oxygen for 24 h (hypoxia-reoxygenation), acrolein accumulated and SMOX mRNA and protein levels were increased. Acrolein induced cell death and fibrosis-related TGFB1 mRNA in HK-2 cells. Administration of the acrolein scavenger cysteamine suppressed the acrolein-induced upregulation of TGFB1 mRNA. Cysteamine also inhibited a decrease in the mitochondrial membrane potential observed by MitoTrackerCMXRos, and cell death induced by hypoxia-reoxygenation. The siRNA-mediated knockdown of SMOX also suppressed hypoxia-reoxygenation-induced acrolein accumulation and cell death. Our study suggests that acrolein exacerbates acute kidney injury by promoting tubular cell death during ischemia-reperfusion injury. Treatment to control the accumulation of acrolein might be an effective therapeutic option for renal ischemia-reperfusion injury.

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  • Acrolein produced during acute kidney injury promotes tubular cell death Reviewed International journal

    Aihara S, Torisu K, Hirashima Y, Kitazono T, Nakano T

    Biochem Biophys Res Commun   2023.7

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  • Usefulness of Serum Leucine-Rich Alpha-2 Glycoprotein as a Surrogate Marker of Small Bowel Mucosal Injury in Crohn's Disease Reviewed International journal

    Saiki T, Torisu T, Harada A, Kajiya Y, Taniguchi Y, Morisaki S, Umeno J, Suekane H, Kitazono T

    Inflamm Intest Dis   2023.7

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  • Incidence and risks of coronary heart disease and heart failure in Japanese patients with type 2 diabetes mellitus: The Fukuoka diabetes registry Reviewed International journal

    Iwase M, Ohkuma T, Fujii H, Oku Y, Higashi T, Oshiro A, Ide H, Nakamura U, Kitazono T

    Diabetes Res Clin Pract   2023.7

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  • Association between decreases in serum uric acid levels and unfavorable outcomes after ischemic stroke: A multicenter hospital-based observational study

    Nakamura, K; Ueki, K; Matsuo, R; Kiyohara, T; Irie, F; Wakisaka, Y; Ago, T; Kamouchi, M; Kitazono, T

    PLOS ONE   18 ( 6 )   e0287721   2023.6   ISSN:1932-6203

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    Background The association between clinical outcomes in ischemic stroke patients and decreases in serum uric acid levels, which often occur during the acute phase, remains unknown. Herein, we aimed to investigate the association using a large-scale, multicenter stroke registry. Methods We analyzed 4,621 acute ischemic stroke patients enrolled in the Fukuoka Stroke Registry between June 2007 and September 2019 whose uric acid levels were measured at least twice during hospitalization (including on admission). The study outcomes were poor functional outcome (modified Rankin Scale score ≥3) and functional dependence (modified Rankin Scale score 3–5) at 3 months after stroke onset. Changes in uric acid levels after admission were evaluated using a decrease rate that was classified into 4 sex-specific grades ranging from G1 (no change/increase after admission) to G4 (most decreased). Multivariable logistic regression analyses were used to assess the associations between decreases in uric acid levels and the outcomes. Results The frequencies of the poor functional outcome and functional dependence were lowest in G1 and highest in G4. The odds ratios (95% confidence intervals) of G4 were significantly higher for poor functional outcome (2.66 [2.05–3.44]) and functional dependence (2.61 [2.00–3.42]) when compared with G1 after adjusting for confounding factors. We observed no heterogeneity in results for subgroups categorized according to age, sex, stroke subtype, neurological severity, chronic kidney disease, or uric acid level on admission. Conclusions Decreases in serum uric acid levels were independently associated with unfavorable outcomes after acute ischemic stroke.

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  • Changes in the Eicosapentaenoic Acid to Arachidonic Acid Ratio in Serum over 10 Years in a Japanese Community: The Hisayama Study

    Honda Takanori, Chen Sanmei, Hata Jun, Shibata Mao, Furuta Yoshihiko, Oishi Emi, Sakata Satoko, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   30 ( 6 )   589 - 600   2023.6   ISSN:13403478 eISSN:18803873

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    <p> <b>Aim:</b> Circulating omega-3 and omega-6 polyunsaturated fatty acids may to contribute to cardiovascular health at the population level. Over a decade, we investigated changes in the serum eicosapentaenoic acid (EPA) to arachidonic acid (AA) ratio, and in serum concentrations of the individual fatty acids, in a Japanese community.</p><p> <b>Methods:</b> Community surveys took place in 2002–2003 and 2012–2013 in a rural area of Japan. The community surveys included 3,194 and 3,220 community dwellers aged ≥ 40 years who did not take EPA medication in 2002–2003 and 2012–2013, respectively. Fatty acid fractionations in serum were measured using a gas chromatography method. Changes in the serum EPA/AA ratio over time were examined using linear mixed models.</p><p><b>Results:</b> Overall, the average serum EPA/AA ratio decreased over the 10 years. A decreasing trend in the serum EPA/AA ratio occurred in all age groups except participants aged ≥ 80 years, with larger decreases in the younger age groups. A similar decline in serum EPA/AA ratio occurred in participants with and those without lipid-lowering therapy. Serum EPA concentrations were slightly increased in the whole population but remained stable or even decreased in participants aged 40–69. In contrast, the average serum AA concentrations increased in all age groups.</p><p><b>Conclusion:</b> In a Japanese community, the serum EPA/AA ratio decreased over 10 years at the population level, especially in middle-aged participants.</p>

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  • Spermidine from arginine metabolism activates Nrf2 and inhibits kidney fibrosis Reviewed International journal

    Aihara S, Torisu K, Uchida Y, Imazu N, Nakano T, Kitazono T

    Commun Biol   2023.6

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  • Changes in the Eicosapentaenoic Acid to Arachidonic Acid Ratio in Serum over 10 Years in a Japanese Community: The Hisayama Study Reviewed International journal

    Honda T, Chen S, Hata J, Shibata M, Furuta Y, Oishi E, Sakata S, Kitazono T, Ninomiya T

    J Atheroscler Thromb   2023.6

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  • Association of white matter lesions and brain atrophy with the development of dementia in a community: the Hisayama Study Reviewed International journal

    Nakazawa T, Ohara T, Hirabayashi N, Furuta Y, Hata J, Shibata M, Honda T, Kitazono T, Nakao T, Ninomiya T

    Psychiatry Clin Neurosci   2023.6

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  • Association between decreases in serum uric acid levels and unfavorable outcomes after ischemic stroke: A multicenter hospital-based observational study Reviewed International journal

    Nakamura K, Ueki K, Matsuo R, Kiyohara T, Irie F, Wakisaka Y, Ago T, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators

    PLoS One   2023.6

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  • Continuous use of antithrombotic medications during peri-endoscopic submucosal dissection period for colorectal lesions: A propensity score matched study Reviewed International journal

    Kawasaki K, Torisu T, Esaki M, Eizuka M, Kawatoko S, Kumei T, Hirai M, Kondo M, Fujioka S, Fuyuno Y, Matsuno Y, Umeno J, Moriyama T, Kitazono T, Sugai T, Matsumoto T

    J Gastroenterol Hepatol   2023.6

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  • Serum Mac-2 Binding Protein Glycosylation Isomer Concentrations Are Associated With Incidence of Type 2 Diabetes Reviewed International journal

    Higashioka M, Hirakawa Y, Hata J, Honda T, Sakata S, Shibata M, Kitazono T, Osawa H, Ninomiya T

    J Clin Endocrinol Metab   2023.6

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  • Small bowel capsule endoscopy examination and open access database with artificial intelligence: The SEE-artificial intelligence project Reviewed International journal

    Yokote A, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Yoshida Y, Imazu N, Miyazono S, Moriyama T, Kitazono T, Torisu T

    DEN Open   2023.6

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  • Association of white matter lesions and brain atrophy with the development of dementia in a community: the Hisayama Study

    Nakazawa, T; Ohara, T; Hirabayashi, N; Furuta, Y; Hata, J; Shibata, M; Honda, T; Kitazono, T; Nakao, T; Ninomiya, T

    PSYCHIATRY AND CLINICAL NEUROSCIENCES   77 ( 6 )   330 - 337   2023.6   ISSN:1323-1316 eISSN:1440-1819

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    Aim: To investigate the association of white matter lesions volume (WMLV) levels with dementia risk and the association between dementia risk and the combined measures of WMLV and either total brain atrophy or dementia-related gray matter atrophy in a general older population. Methods: One thousand one hundred fifty-eight Japanese dementia-free community-residents aged ≥65 years who underwent brain magnetic resonance imaging were followed for 5.0 years. WMLV were segmented using the Lesion Segmentation Toolbox. Total brain volume (TBV) and regional gray matter volume were estimated by voxel-based morphometry. The WMLV-to-intracranial brain volume ratio (WMLV/ICV) was calculated, and its association with dementia risk was estimated using Cox proportional hazard models. Total brain atrophy, defined as the TBV-to-ICV ratio (TBV/ICV), and dementia-related regional brain atrophy defined based on our previous report were calculated. The association between dementia risk and the combined measures of WMLV/ICV and either total brain atrophy or the number of atrophied regions was also tested. Results: During the follow-up, 113 participants developed dementia. The risks of dementia increased significantly with higher WMLV/ICV levels. In addition, dementia risk increased additively both in participants with higher WMLV/ICV levels and lower TBV/ICV levels and in those with higher WMLV/ICV levels and a higher number of dementia-related brain regional atrophy. Conclusion: The risk of dementia increased significantly with higher WMLV/ICV levels. An additive increment in dementia risk was observed with higher WMLV/ICV levels and lower TBV/ICV levels or a higher number of dementia-related brain regional atrophy, suggesting the importance of prevention or control of cardiovascular risk factors.

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  • Decreased Estimated Glomerular Filtration Rate and Proteinuria and Long-Term Outcomes After Ischemic Stroke: A Longitudinal Observational Cohort Study Reviewed International journal

    Ueki K, Matsuo R, Kuwashiro T, Irie F, Wakisaka Y, Ago T, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators

    Stroke   2023.5

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  • Non-linear association between body weight and functional outcome after acute ischemic stroke Reviewed International journal

    Wakisaka K, Matsuo R, Matsumoto K, Nohara Y, Irie F, Wakisaka Y, Ago T, Nakashima N, Kamouchi M, Kitazono T

    Sci Rep   2023.5

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  • Sex differences in cardiovascular risk, lifestyle, and psychological factors in patients with type 2 diabetes: the Fukuoka Diabetes Registry Reviewed International journal

    Ohkuma T, Iwase M, Fujii H, Kitazono T

    Biol Sex Differ   2023.5

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  • National trends in the outcomes of subarachnoid haemorrhage and the prognostic influence of stroke centre capability in Japan: retrospective cohort study Reviewed International journal

    Shimogawa T, Yoshimoto K, Onozuka D, Ogata S, Hagihara A, Saito N, Arai H, Miyamoto S, Tominaga T, Iihara K; J-ASPECT Study Collaborators

    BMJ Open   2023.4

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  • The Association of Controlling Nutritional Status Score and Prognostic Nutritional Index with Cardiovascular Diseases: the Fukuoka Kidney Disease Registry Study Reviewed International journal

    Tsuda S, Nakayama M, Tanaka S, Haruyama N, Yoshitomi R, Fukui A, Tsuruya K, Nakano T, Kitazono T

    J Atheroscler Thromb   2023.4

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  • Simplified geriatric nutritional risk index for assessing nutritional status and stratifying mortality risk in patients receiving maintenance hemodialysis Reviewed International journal

    Yamada S, Arase H, Taniguchi M, Kitazono T, Nakano T

    Ther Apher Dial   2023.4

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  • Design and methods of an open-label, randomized controlled trial to evaluate the effect of pemafibrate on proteinuria in CKD patients (PROFIT-CKD) Reviewed International journal

    Seki M, Nakano T, Tanaka S, Matsukuma Y, Funakoshi K, Ohkuma T, Kitazono T

    Clin Exp Nephrol   2023.4

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  • PDGFR β-positive cell-mediated post-stroke remodeling of fibronectin and laminin α 2 for tissue repair and functional recovery Reviewed International journal

    2023.4

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  • Association between microscopic hematuria and albuminuria in patients with chronic kidney disease caused by diabetes and hypertension: the Fukuoka Kidney disease Registry Study Reviewed International journal

    Nakagawa K, Tanaka S, Tsuruya K, Kitazono T, Nakano T

    Clin Exp Nephrol   2023.3

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  • Efficacy and Safety of Prasugrel vs Clopidogrel in Thrombotic Stroke Patients With Risk Factors for Ischemic Stroke Recurrence: A Double-blind, Phase III Study (PRASTRO-III) Reviewed International journal

    Kitazono T, Kamouchi M, Matsumaru Y, Nakamura M, Umemura K, Matsuo H, Koyama N, Tsutsumi J, Kimura K

    J Atheroscler Thromb   2023.3

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  • Deletion of Nox4 enhances remyelination following cuprizone-induced demyelination by increasing phagocytic capacity of microglia and macrophages in mice Reviewed International journal

    Yamanaka K, Nakamura K, Shibahara T, Takashima M, Takaki H, Hidaka M, Komori M, Yoshikawa Y, Wakisaka Y, Ago T, Kitazono T

    Glia   2023.3

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  • Association of gait speed with regional brain volumes and risk of dementia in older Japanese: The Hisayama study Reviewed International journal

    Tajimi T, Furuta Y, Hirabayashi N, Honda T, Hata J, Ohara T, Shibata M, Nakao T, Kitazono T, Nakashima Y, Ninomiya T

    Arch Gerontol Geriatr   2023.3

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  • Association of gait speed with regional brain volumes and risk of dementia in older Japanese: The Hisayama study

    Tajimi, T; Furuta, Y; Hirabayashi, N; Honda, T; Hata, J; Ohara, T; Shibata, M; Nakao, T; Kitazono, T; Nakashima, Y; Ninomiya, T

    ARCHIVES OF GERONTOLOGY AND GERIATRICS   106   104883   2023.3   ISSN:0167-4943 eISSN:1872-6976

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    Background: To investigate the association of gait speed with regional brain volumes and the risk of incident dementia. Methods: A total of 1112 dementia-free Japanese residents aged ≥65 years who underwent brain magnetic resonance imaging were followed for 5.0 years (median). The participants were classified into the age- and sex-specific quartile levels of maximum gait speed. Regional gray matter volumes (GMV) and white matter hyperintensities volumes (WMHV) were measured by applying voxel-based morphometry methods. The cross-sectional association of maximum gait speed with regional GMV was examined using an analysis of covariance. We also estimated the association between maximum gait speed level and the risk of developing dementia using a Cox proportional hazards model. Mediation analyses were conducted to determine the contribution of regional brain volumes to the association between maximum gait speed and dementia. Results: Lower maximum gait speed was significantly associated with lower GMV of the total brain, frontal lobe, temporal lobe, cingulate gyrus, insula, hippocampus, amygdala, basal ganglia, thalamus, and cerebellum, and increased WMHV at baseline. During the follow-up, 108 participants developed dementia. The incidence rate of all dementias increased significantly with decreasing maximum gait speed after adjusting for potential confounders (P for trend = 0.03). The mediating effects of the GMV of the hippocampus, GMV of the insula, and WMHV were significant. Conclusions: Lower maximum gait speed was significantly associated with an increased risk of dementia. Reduced GMV of the hippocampus or insula, and an increase in WMHV was likely to be involved in this association.

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  • Association between microscopic hematuria and albuminuria in patients with chronic kidney disease caused by diabetes and hypertension: the Fukuoka Kidney disease Registry Study

    Nakagawa, K; Tanaka, S; Tsuruya, K; Kitazono, T; Nakano, T

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   27 ( 3 )   227 - 235   2023.3   ISSN:1342-1751 eISSN:1437-7799

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    Background: The association between microscopic hematuria (MH) and albuminuria in patients with chronic kidney disease (CKD) caused by diabetes and hypertension remains unclear. Methods: The Fukuoka Kidney disease Registry Study is a Japanese multicenter prospective cohort study of 4476 patients with non-dialysis-dependent CKD. In this cohort, we conducted a cross-sectional study in 994 patients with diabetic nephropathy and hypertensive nephrosclerosis. Patients were divided into three groups according to erythrocyte count in urine sediment [T1: < 5/high power field (HPF); T2: 5–9/HPF; T3: ≥ 10/HPF]. Macroalbuminuria was defined as urinary albumin-creatinine ratio > 300 mg/g. Associations between the degree of MH (T1–T3) and the prevalence of macroalbuminuria were analyzed using logistic regression. Results: The prevalence of macroalbuminuria was 50.8%, 50.4%, and 67.4% in T1 (n = 725), T2 (n = 226), and T3 (n = 43), respectively. The multivariable-adjusted odds ratios for the presence of macroalbuminuria were 0.95 [95% confidence interval (CI) 0.65–1.39; P = 0.86] and 2.50 (95% CI 1.15–5.47; P = 0.022) for patients in T2 and T3, respectively, compared with patients in T1. Conclusions: MH with erythrocytes ≥ 10/HPF was significantly associated with increased prevalence of macroalbuminuria in patients with non-dialysis-dependent CKD caused by diabetes and hypertension.

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  • Association between prevalence of laxative use and history of bone fractures and cardiovascular diseases in patients with chronic kidney disease: the Fukuoka Kidney disease Registry (FKR) study Reviewed International journal

    Yamada S, Tanaka S, Arase H, Hiyamuta H, Kitamura H, Tokumoto M, Mitsuiki K, Tsuruya K, Kitazono T, Nakano T

    Clin Exp Nephrol   2023.2

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  • Painless thyroiditis mimicking relapse of hyperthyroidism during or after potassium iodide or thionamide therapy for Graves' disease resulting in remission Reviewed International journal

    Okamura K, Sato K, Fujikawa M, Bandai S, Ikenoue H, Kitazono T

    Endocr J   2023.2

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  • Association between prevalence of laxative use and history of bone fractures and cardiovascular diseases in patients with chronic kidney disease: the Fukuoka Kidney disease Registry (FKR) study

    Yamada, S; Tanaka, S; Arase, H; Hiyamuta, H; Kitamura, H; Tokumoto, M; Mitsuiki, K; Tsuruya, K; Kitazono, T; Nakano, T

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   27 ( 2 )   151 - 160   2023.2   ISSN:1342-1751 eISSN:1437-7799

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    Background: Constipation is a common complication in patients with chronic kidney disease (CKD) and is involved in the pathogenesis of dysbiosis and progression of CKD. However, little is known about its association with disorders of the bone–cardiovascular axis in patients with CKD. Methods: We performed a cross-sectional analysis of 3878 patients with CKD using the baseline dataset of the Fukuoka Kidney disease Registry study, as a multicenter, prospective cohort study of pre-dialysis CKD patients. The main exposure of interest was constipation defined as use of at least one type of laxative. The main outcomes were the histories of bone fractures and cardiovascular diseases (CVDs) as manifestations of disorders of the bone–cardiovascular axis. Results: The prevalences of laxative use and histories of bone fractures and CVDs increased as kidney function declined. Among the 3878 patients, 532 (13.7%) patients used laxatives, 235 (6.1%) patients had prior bone fractures, and 1001 (25.8%) patients had prior CVDs. Histories of bone fractures and CVDs were significantly more prevalent among laxative users (P < 0.05). Multivariable-adjusted logistic regression analysis revealed that patients with laxatives had a significantly higher odds ratios for histories of bone fractures and CVDs than those without laxatives [adjusted odds ratios (95% confidence intervals) 1.67 (1.20–2.31) and 1.70 (1.30–2.22), respectively, P < 0.05]. Conclusions: These results suggest that constipation indicated by laxative use is associated with increased prevalences of historical bone fractures and CVDs in pre-dialysis patients with CKD.

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  • Intravenous nicardipine for Japanese patients with acute intracerebral hemorrhage: an individual participant data analysis Reviewed International journal

    Toyoda K, Yoshimura S, Fukuda-Doi M, Qureshi AI, Inoue M, Miwa K, Koga M; ATACH Trial Investigators; SAMURAI Investigators

    Hypertens Res   2023.1

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  • Association between hyporesponsiveness to erythropoiesis-stimulating agents and risk of brain hemorrhage in patients undergoing hemodialysis: the Q-Cohort Study Reviewed International journal

    Uchida Y, Nakano T, Kitamura H, Taniguchi M, Tsuruya K, Kitazono T

    Clin Exp Nephrol   2023.1

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  • Intravenous Alteplase at 0.6 mg/kg for Unknown Onset Stroke with Prior Antithrombotic Medication: THAWS Randomized Clinical Trial Reviewed International journal

    Koga M, Inoue M, Miwa K, Yoshimura S, Fukuda-Doi M, Aoki J, Asakura K, Kanzawa T, Ohtaki M, Kamiyama K, Yakushiji Y, Igarashi S, Doijiri R, Ito Y, Takagi Y, Sasaki M, Kitazono T, Kimura K, Minematsu K, Yamamoto H, Toyoda K

    J Atheroscler Thromb   2023.1

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  • Association between hyporesponsiveness to erythropoiesis-stimulating agents and risk of brain hemorrhage in patients undergoing hemodialysis: the Q-Cohort Study

    Uchida, Y; Nakano, T; Kitamura, H; Taniguchi, M; Tsuruya, K; Kitazono, T

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   27 ( 1 )   79 - 88   2023.1   ISSN:1342-1751 eISSN:1437-7799

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    Background: Hyporesponsiveness to erythropoiesis-stimulating agents (ESAs) is associated with increased risks of all cause and cardiovascular mortality in patients undergoing hemodialysis (HD). However, the impact of the hematopoietic response to ESAs on the development of stroke, including brain hemorrhage and infarction, remains unclear. Methods: In total, 2886 patients undergoing maintenance HD registered in the Q-Cohort Study who were treated with ESAs were prospectively followed up for 4 years. The hematopoietic response to ESAs was evaluated by the erythropoietin resistance index (ERI), calculated by dividing the weekly dose of ESA by post-HD weight and hemoglobin (U/kg/week/g/dL). The primary outcomes were the incidences of brain hemorrhage and infarction. Patients were divided into quartiles based on their ERI at baseline (Q1, ≤ 4.1; Q2, 4.2–7.0; Q3, 7.1–11.2; and Q4, ≥ 11.3). The risks of brain hemorrhage and infarction were estimated using Cox proportional hazards models, adjusting for potential confounders. Results: During the 4 year follow-up period, 71 patients developed brain hemorrhage and 116 developed brain infarction. In the multivariable analysis, the incidence of brain hemorrhage in the highest quartile (Q4) was significantly higher than that in the lowest quartile (Q1) (hazard ratio [95% confidence interval], 2.18 [1.08–4.42]). However, the association between the ERI and the incidence of brain infarction was not significant. Conclusions: A higher ERI was associated with an increased risk of brain hemorrhage, but not brain infarction, in patients undergoing maintenance HD. A high ERI is thus an important risk factor for brain hemorrhage in these patients.

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  • Association between Early Cognitive Impairment and Short-Term Functional Outcome in Acute Ischemic Stroke

    Kiyohara, T; Kumai, Y; Yubi, T; Ishikawa, E; Wakisaka, Y; Ago, T; Kitazono, T

    CEREBROVASCULAR DISEASES   52 ( 1 )   61 - 67   2023.1   ISSN:1015-9770 eISSN:1421-9786

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    Background: Little is known about the association between poststroke cognitive impairment (PSCI) and functional outcome in the acute care phase of ischemic stroke and the influence of the clinical condition of acute stroke on this association. We examined this issue, taking into account stroke-related factors, in a hospital-based prospective study of patients with acute ischemic stroke. The same analysis was also performed after subsequent rehabilitation to investigate whether the association observed in the acute care phase persisted after that. For comparison, the same analysis was performed for pre-stroke dementia (PreSD). Methods: We included in the study a total of 923 patients with acute ischemic stroke who were admitted to a hospital from 2012 to 2020 in Japan. Cognitive function was assessed using the Mini-Mental State Examination and Raven's Colored Progressive Matrices test at an average of 6.3 days after stroke onset. The subjects were divided into three groups with normal cognition, PSCI, and PreSD. Study outcome was a poor functional outcome, defined as a modified Rankin Scale score of ≥3 at the end of acute care (median 21 days after admission). Among total subjects, 460 were also assessed for poor functional outcome after rehabilitation (median 77 days after admission). A logistic regression model was applied in this study. Results: Patients with PSCI and PreSD had higher median National Institute of Health Stroke Scale scores than those with normal cognition (median [IQR]: 3 [2-6], 4 [2-12], and 2 [1-4], respectively). The age- and sex-adjusted cumulative incidence of poor functional outcome was significantly higher in patients with PSCI and PreSD than in those with normal cognition in the acute care and rehabilitation phases. In the acute care phase, these associations remained significant after adjustment for stroke-related factors and other confounders (multivariable-adjusted odds ratio [95% CI] for PSCI vs. normal cognition: 3.28 [2.07-5.20]; for PreSD: 2.39 [1.40-4.08]). Similar results were observed in the rehabilitation phase (for PSCI: 2.48 [1.31-4.70]; for PreSD: 3.92 [1.94-7.92]). Conclusions: Our findings suggest that PSCI, as well as PreSD, is possibly associated with the development of poor functional outcome in the acute care phase of ischemic stroke, and this association continues thereafter.

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  • Cardiovascular Risk Factor Burden and Treatment Control in Patients with Chronic Kidney Disease: A Cross-Sectional Study

    Kitamura, H; Tanaka, S; Hiyamuta, H; Shimamoto, S; Tsuruya, K; Nakano, T; Kitazono, T; FKR Study Collaboration Grp

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   30 ( 9 )   1210 - 1228   2023   ISSN:1340-3478 eISSN:1880-3873

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    Aim: Cardiovascular disease is a life-threatening chronic kidney disease (CKD) complication. Although cardiovascular risk factor management is significant in patients with CKD, there are few reports that detail the frequency of complications and the treatment of cardiovascular risk factors at different stages of CKD in clinical practice. Methods: There were a total of 3,407 patients with non-dialysis-dependent CKD who participated in the Fukuoka Kidney disease Registry Study, and they were cross-sectionally analyzed. The patients were classified into five groups based on their estimated glomerular filtration rate and urinary albumin to creatinine ratio according to Kidney Disease: Improving Global Outcomes 2012 guidelines, which recommend low, moderate, high, very high, and extremely high risk groups. The primary outcomes were the cardiovascular risk factor burden and the treatment status of cardiovascular risk factors. Using a logistic regression model, the association between the CKD groups and the treatment status of each risk factor was examined. Results: The proportion of patients with hypertension, diabetes mellitus, and dyslipidemia significantly increased as CKD progressed, whereas the proportion of patients who achieved cardiovascular risk factor treatment targets significantly decreased. In the multivariable analysis, the odds ratios (ORs) of uncontrolled treatment targets were significantly higher for hypertension (OR 3.68) in the extremely high risk group than in the low risk group. Conclusions: Patients with non-dialysis-dependent CKD demonstrate an increased cardiovascular risk factor burden with greater severity of CKD. Extremely high risk CKD is associated with difficulty in managing hypertension.

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  • Onset of type 1 diabetes during bone growth period is associated with increased prevalence of bone fracture: A post-hoc analysis of a cross-sectional study Reviewed International journal

    Komorita Y, Minami M, Maeda Y, Kishita R, Ohkuma T, Kitazono T

    J Diabetes Investig   2022.12

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  • Cardiovascular Risk Factor Burden and Treatment Control in Patients with Chronic Kidney Disease: A Cross-Sectional Study Reviewed International journal

    Kitamura H, Tanaka S, Hiyamuta H, Shimamoto S, Tsuruya K, Nakano T, Kitazono T; FKR Study Collaboration Group

    J Atheroscler Thromb   2022.12

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  • CKD, Brain Atrophy, and White Matter Lesion Volume: The Japan Prospective Studies Collaboration for Aging and Dementia Reviewed International journal

    Maki K, Ohara T, Hata J, Shibata M, Hirabayashi N, Honda T, Sakata S, Furuta Y, Akiyama M, Yamasaki K, Tatewaki Y, Taki Y, Kitazono T, Mikami T, Maeda T, Ono K, Mimura M, Nakashima K, Iga JI, Takebayashi M, Ninomiya T; Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) study group

    Kidney Med   2022.12

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  • Long-Term Trends in The 5-Year Risk of Recurrent Stroke over A Half Century in A Japanese Community: The Hisayama Study Reviewed International journal

    Nakanishi Y, Furuta Y, Hata J, Yubi T, Oishi E, Sakata S, Hirakawa Y, Wakisaka Y, Ago T, Kitazono T, Ninomiya T

    J Atheroscler Thromb   2022.12

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  • Serum lipopolysaccharide-binding protein levels and the incidence of metabolic syndrome in a general Japanese population: the Hisayama Study Reviewed International journal

    Tomooka S, Oishi E, Asada M, Sakata S, Hata J, Chen S, Honda T, Suzuki K, Watanabe H, Murayama N, Wada N, Kitazono T, Ninomiya T

    J Epidemiol   2022.12

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  • Stroke genetics informs drug discovery and risk prediction across ancestries Reviewed International journal

    Nature   2022.11

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  • Current antihypertensive treatment and treatment-resistant hypertension in Japanese patients with chronic kidney disease Invited Reviewed International journal

    Tsuchimoto A, Tanaka S, Kitamura H, Hiyamuta H, Tsuruya K, Kitazono T, Nakano T; Fukuoka Kidney disease Registry (FKR) study corporation

    Clin Exp Nephrol   2022.11

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  • Glucose degradation products in peritoneal dialysis solution impair angiogenesis by dysregulating angiogenetic factors in endothelial and vascular smooth muscle cells Reviewed International journal

    Aihara S, Nakano T, Torisu K, Kitazono T

    Clin Exp Nephrol   2022.11

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  • Low intake of β carotene and dietary fiber from vegetables and fruits in patients with chronic kidney disease Reviewed International journal

    2022.11

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  • Serum alkaline phosphatase and infection-related mortality in hemodialysis patients: ten-year outcomes of the Q-cohort study Reviewed International journal

    Kitamura H, Yotsueda R, Hiyamuta H, Taniguchi M, Tanaka S, Yamada S, Tsuruya K, Nakano T, Kitazono T

    Clin Exp Nephrol   2022.11

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  • Associations Between Adherence to Evidence-Based, Stroke Quality Indicators and Outcomes of Acute Reperfusion Therapy Reviewed International journal

    Ren N, Ogata S, Kiyoshige E, Nishimura K, Nishimura A, Matsuo R, Kitazono T, Higashi T, Ogasawara K, Iihara K; Close The Gap-Stroke, J-ASPECT Study Collaborators*

    Stroke   2022.11

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  • Arginine Metabolism Regulates the Transcription Factor Nrf2 and Prevents Renal Interstitial Fibrosis Through Tubular Spermidine Production

    Aihara, S; Torisu, K; Nakano, T; Kitazono, T

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   33 ( 11 )   589 - 589   2022.11   ISSN:1046-6673 eISSN:1533-3450

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  • Cardiovascular Risk Factor Burden and Treatment Control in Patients With CKD: The Fukuoka Kidney Disease Registry (FKR) Study

    Kitamura, H; Tanaka, S; Hiyamuta, H; Shimamoto, S; Tsuruya, K; Nakano, T; Kitazono, T

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   33 ( 11 )   219 - 220   2022.11   ISSN:1046-6673 eISSN:1533-3450

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  • Associations Between Adherence to Evidence-Based, Stroke Quality Indicators and Outcomes of Acute Reperfusion Therapy

    Ren, NC; Ogata, S; Kiyoshige, E; Nishimura, K; Nishimura, A; Matsuo, R; Kitazono, T; Higashi, T; Ogasawara, K; Iihara, K

    STROKE   53 ( 11 )   3359 - 3368   2022.11   ISSN:0039-2499 eISSN:1524-4628

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    Background: Quality indicators (QIs) are an accepted tool for measuring a hospital's performance in routine care. We examined national trends in adherence to the QIs developed by the Close The Gap-Stroke program by combining data from the health insurance claims database and electronic medical records, and the association between adherence to these QIs and early outcomes in patients with acute ischemic stroke in Japan. Methods: In the present study, patients with acute ischemic stroke who received acute reperfusion therapy in 351 Close The Gap-Stroke-participating hospitals were analyzed retrospectively. The primary outcomes were changes in trends for adherence to the defined QIs by difference-in-difference analysis and the effects of adherence to distinct QIs on in-hospital outcomes at the individual level. A mixed logistic regression model was adjusted for patient and hospital characteristics (eg, age, sex, number of beds) and hospital units as random effects. Results: Between 2013 and 2017, 21 651 patients (median age, 77 years; 43.0% female) were assessed. Of the 25 defined measures, marked and sustainable improvement in the adherence rates was observed for door-to-needle time, door-to-puncture time, proper use of endovascular thrombectomy, and successful revascularization. The in-hospital mortality rate was 11.6%. Adherence to 14 QIs lowered the odds of in-hospital mortality (odds ratio [95% CI], door-to-needle <60 min, 0.80 [0.69-0.93], door-to-puncture <90 min, 0.80 [0.67-0.96], successful revascularization, 0.40 [0.34-0.48]), and adherence to 11 QIs increased the odds of functional independence (modified Rankin Scale score 0-2) at discharge. Conclusions: We demonstrated national marked and sustainable improvement in adherence to door-to-needle time, door-to-puncture time, and successful reperfusion from 2013 to 2017 in Japan in patients with acute ischemic stroke. Adhering to the key QIs substantially affected in-hospital outcomes, underlining the importance of monitoring the quality of care using evidence-based QIs and the nationwide Close The Gap-Stroke program.

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  • The presence of sodium glucose co-transporter 2 in mesangial cells and pericytes and its roles in mesangial lesions and in capillaries under diabetic and ischemic conditions Reviewed International journal

    Wakisaka M, Nakamura K, Kitazono T

    Diabetes Res Clin Pract   2022.10

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  • Active commuting, commuting modes and the risk of diabetes: 14-year follow-up data from the Hisayama study Reviewed International journal

    Honda T, Hirakawa Y, Hata J, Chen S, Shibata M, Sakata S, Furuta Y, Higashioka M, Oishi E, Kitazono T, Ninomiya T

    J Diabetes Investig   2022.10

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  • Day-to-Day Blood Pressure Variability and Risk of Incident Chronic Kidney Disease in a General Japanese Population Reviewed International journal

    Sasaki T, Sakata S, Oishi E, Furuta Y, Honda T, Hata J, Tsuboi N, Kitazono T, Yokoo T, Ninomiya T

    J Am Heart Assoc   2022.10

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  • Active commuting, commuting modes and the risk of diabetes: 14-year follow-up data from the Hisayama study

    Honda, T; Hirakawa, Y; Hata, J; Chen, SM; Shibata, M; Sakata, S; Furuta, Y; Higashioka, M; Oishi, E; Kitazono, T; Ninomiya, T

    JOURNAL OF DIABETES INVESTIGATION   13 ( 10 )   1677 - 1684   2022.10   ISSN:2040-1116 eISSN:2040-1124

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    Aims/Introduction: We aimed to investigate the association of active commuting (cycling or walking to work), as well as the association of the individual commuting modes, with the risk of diabetes in a prospective cohort of community-dwelling adults in Japan. Material and Methods: A total of 1,270 residents aged 40–79 years were followed up for a median of 14 years. Active commuting was defined as either cycling or walking to work. A Cox proportional hazards model was used to examine the association of active commuting with the risk of diabetes. Associations for different forms of active commuting (cycling, walking and mixed modes of cycling or walking with non-active components) were also examined. Results: During the follow-up period, 191 participants developed diabetes. Active commuting was associated with a lower risk of diabetes than non-active commuting after adjustment for potential confounders (hazard ratio [HR] 0.54, 95% confidence interval [CI] 0.31–0.92). With regard to the commuting modes, the risk of diabetes was significantly lower in individuals who commuted by cycling alone (HR 0.46, 95% CI 0.22–0.98), and tended to be lower in individuals who commuted by walking alone (HR 0.14, 95% CI 0.02–1.02) compared with that in individuals with non-active commuting. Meanwhile, no significant associations were observed for the mixed mode of walking and non-active commuting (HR 1.69, 95% CI 0.77–3.71). Conclusions: Active commuting, particularly that consisting exclusively of cycling or walking, was associated with a reduced risk of diabetes. Our findings support a public health policy that promotes the choice of active commuting for the prevention of diabetes.

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  • Risks of Mortality and Airflow Limitation in Japanese Individuals with Preserved Ratio Impaired Spirometry Reviewed International journal

    Washio Y, Sakata S, Fukuyama S, Honda T, Kan-O K, Shibata M, Hata J, Inoue H, Kitazono T, Matsumoto K, Ninomiya T

    Am J Respir Crit Care Med   2022.9

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  • Prevalence, treatment status, and predictors of anemia and erythropoietin hyporesponsiveness in Japanese patients with non-dialysis-dependent chronic kidney disease: a cross-sectional study Reviewed International journal

    Tanaka S, Kitamura H, Tsuruya K, Kitazono T, Nakano T; FKR Study Collaboration Group

    Clin Exp Nephrol   2022.9

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  • Changes in the Eicosapentaenoic Acid to Arachidonic Acid Ratio in Serum over 10 Years in a Japanese Community: The Hisayama Study Reviewed International journal

    Honda T, Chen S, Hata J, Shibata M, Furuta Y, Oishi E, Sakata S, Kitazono T, Ninomiya T

    J Atheroscler Thromb   2022.9

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  • Filamin A Variant as a Possible Second-Hit Gene Promoting Moyamoya Disease-like Vascular Formation Associated With RNF213 p.R4810K Variant Reviewed International journal

    Ikeuchi Y, Kitayama J, Sahara N, Okata T, Miyake N, Matsumoto N, Kitazono T, Ago T

    Neurol Genet.   2022.9

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  • Potential therapeutic targets discovery by transcriptome analysis of an in vitro human gastric signet ring carcinoma model Reviewed International journal

    Yamaguchi K, Yoshihiro T, Ariyama H, Ito M, Nakano M, Semba Y, Nogami J, Tsuchihashi K, Yamauchi T, Ueno S, Isobe T, Shindo K, Moriyama T, Ohuchida K, Nakamura M, Nagao Y, Ikeda T, Hashizume M, Konomi H, Torisu T, Kitazono T, Kanayama T, Tomita H, Oda Y, Kusaba H, Maeda T, Akashi K, Baba E

    Gastric Cancer   2022.9

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  • Solid-type poorly differentiated adenocarcinoma of the stomach: A characteristic morphology reveals a distinctive immunoregulatory tumor microenvironment Reviewed International journal

    Kawatoko S, Kohashi K, Torisu T, Sasaki T, Umekita S, Oki E, Nakamura M, Kitazono T, Oda Y.

    Pathol Res Pract   2022.9

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  • Prediction of intracranial lesions in patients with consciousness disturbance by ultrasonography in the intensive care unit Reviewed International journal

    Shono Y, Mezuki S, Akahoshi T, Nishihara M, Kaku N, Maki J, Tokuda K, Kitazono T

    J Int Med Res   2022.9

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  • Association between Multimorbidity and Kidney Function among Patients with Non-Dialysis-Dependent CKD: The Fukuoka Kidney Disease Registry Study

    Tanaka Shigeru, Nakano Toshiaki, Hiyamuta Hiroto, Tsuruya Kazuhiko, Kitazono Takanari

    Journal of Atherosclerosis and Thrombosis   29 ( 8 )   1249 - 1264   2022.8   ISSN:13403478 eISSN:18803873

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    <p><b>Aim:</b> Individuals with chronic kidney disease (CKD) have a high prevalence of comorbidities, including cardiovascular disease (CVD) and its risk factors. However, epidemiological results to assess the association between multimorbidity and kidney function among the CKD population remains limited.</p><p><b>Methods:</b> We performed a cross-sectional analysis of the association between 23 comorbid conditions and reduced kidney function in 4,476 patients with non-dialysis-dependent CKD enrolled in a multicenter cohort in Japan. Reduced kidney function was defined as an estimated glomerular filtration rate of ≤ 60 mL/min/1.73 m<sup>2</sup>.</p><p><b>Results:</b> The mean age of patients was 67 years (male, 56.0%). The prevalence of hypertension, diabetes mellitus, dyslipidemia, prior CVD, cancer, and bone fracture, which are the major comorbidities, was 83.3%, 28.7%, 45.9%, 23.3%, 12.7%, and 6.3%, respectively. Multivariable-adjusted analyses revealed that age, male sex, hypertension, dyslipidemia, prior CVD, body mass index, urinary protein excretion, and underlying kidney disease were independent factors associated with reduced kidney function. Importantly, the odds ratios (ORs) for reduced kidney function increased linearly as the number of major comorbid conditions increased (OR for 1–2 conditions: 2.22, 95% confidence interval [CI]: 1.65–2.97; OR for 3–4 conditions: 3.04, 95% CI: 2.12–4.37; OR for ≥ 5 conditions: 4.37, 95% CI: 1.75–10.9). The upward trend in OR was more pronounced with cardiovascular comorbidities but not significant with non-cardiovascular comorbidities.</p><p><b>Conclusions:</b> In conclusion, we observed an independent association between cardiovascular comorbidity and its risk factors and reduced kidney function. The results of this study highlight the importance of managing multimorbidity among patients with CKD.</p>

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  • Iodide-sensitive Graves' hyperthyroidism and the strategy for resistant or escaped patients during potassium iodide treatment Reviewed International journal

    Okamura K, Sato K, Fujikawa M, Bandai S, Ikenoue H, Kitazono T

    Endocr J   2022.8

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  • Hyperoxemia is Associated With Poor Neurological Outcomes in Patients With Out-of-Hospital Cardiac Arrest Rescued by Extracorporeal Cardiopulmonary Resuscitation: Insight From the Nationwide Multicenter Observational JAAM-OHCA (Japan Association for Acute Medicine) Registry Reviewed International journal

    Nishihara M, Hiasa KI, Enzan N, Ichimura K, Iyonaga T, Shono Y, Kashiura M, Moriya T, Kitazono T, Tsutsui H

    J Emerg Med   2022.8

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  • Association between Multimorbidity and Kidney Function among Patients with Non-Dialysis-Dependent CKD: The Fukuoka Kidney Disease Registry Study Reviewed International journal

    Tanaka S, Nakano T, Hiyamuta H, Tsuruya K, Kitazono T

    J Atheroscler Thromb   2022.8

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  • Remote ischemic conditioning for acute ischemic stroke part 2: Study protocol for a randomized controlled trial Reviewed International journal

    Ishizuka K, Hoshino T, Toi S, Mizuno T, Hosoya M, Saito M, Sato Y, Yagita Y, Todo K, Sakaguchi M, Ohashi T, Maruyama K, Hino S, Honma Y, Doijiri R, Yamagami H, Iguchi Y, Hirano T, Kimura K, Kitazono T, Kitagawa K

    Front Neurol   2022.8

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  • Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community

    Mihara, A; Ohara, T; Hata, J; Chen, S; Honda, T; Tamrakar, S; Isa, A; Wang, D; Shimizu, K; Katakura, Y; Yonemoto, K; Nakao, T; Kitazono, T; Ninomiya, T

    SCIENTIFIC REPORTS   12 ( 1 )   12427   2022.7   ISSN:2045-2322

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    We examined the association of serum s-adenosylmethionine (SAM), s-adenosylhomocysteine (SAH) (methionine metabolites), and their ratio on the risk of dementia and death in a community-dwelling population of older Japanese individuals. 1371 residents of Hisayama, Japan, aged 65 years or older and without dementia, were followed for a median of 10.2 years (2007–2017). We divided serum SAM, SAH, and SAM/SAH ratio into quartiles. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) of serum SAM, SAH, and SAM/SAH ratio levels on the risk of a composite outcome of all-cause dementia or death, and each outcome. During the follow-up, 635 participants developed all-cause dementia and/or died, of which 379 participants developed dementia and 394 deaths occurred. The multivariable-adjusted HRs of the composite outcome decreased significantly with increasing serum SAM levels (P for trend = 0.01), while they increased significantly with higher serum SAH levels (P for trend = 0.03). Higher serum SAM/SAH ratio levels were significantly associated with a lower risk of the composite outcome (P for trend = 0.002), as well as with lower risk of each outcome. Our findings suggest that the balance of methionine metabolites may closely associate with the risk of dementia and death.

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  • Causes of ischemic stroke in young adults versus non-young adults: A multicenter hospital-based observational study Reviewed International journal

    Ohya Y, Matsuo R, Sato N, Irie F, Nakamura K, Wakisaka Y, Ago T, Kamouchi M, Kitazono T; Investigators for Fukuoka Stroke Registry

    PLoS One   2022.7

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  • Fluid-attenuated inversion recovery vascular hyperintensity-diffusion-weighted imaging mismatch and functional outcome after endovascular reperfusion therapy for acute ischemic stroke Reviewed International journal

    Tokunaga K, Tokunaga S, Hara K, Yasaka M, Okada Y, Kitazono T, Tsumoto T

    Interv Neuroradiol   2022.7

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  • Low-dose sodium-glucose cotransporter 2 inhibitor ameliorates ischemic brain injury in mice through pericyte protection without glucose-lowering effects Reviewed International journal

    Takashima M, Nakamura K, Kiyohara T, Wakisaka Y, Hidaka M, Takaki H, Yamanaka K, Shibahara T, Wakisaka M, Ago T, Kitazono T

    Commun Biol   2022.7

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  • Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community Reviewed International journal

    Mihara A, Ohara T, Hata J, Chen S, Honda T, Tamrakar S, Isa A, Wang D, Shimizu K, Katakura Y, Yonemoto K, Nakao T, Kitazono T, Ninomiya T

    Sci Rep   2022.7

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  • Causes of ischemic stroke in young adults versus non-young adults: A multicenter hospital-based observational study

    Ohya Y., Matsuo R., Sato N., Irie F., Nakamura K., Wakisaka Y., Ago T., Kamouchi M., Kitazono T.

    PLoS ONE   17 ( 7 July )   e0268481   2022.7

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    Background Very few comparative studies have focused on the differences in the causes of ischemic stroke between young adults and non-young adults. This study was performed to determine what causes of ischemic stroke are more important in young adults than in non-young adults using a large-scale multicenter hospital-based stroke registry in Fukuoka, Japan. Methods and results We investigated data on 15,860 consecutive patients aged ≥18 years with acute ischemic stroke (mean age: 73.5 ± 12.4 years, 58.2% men) who were hospitalized between 2007 and 2019. In total, 779 patients were categorized as young adults (≤50 years of age). Although vascular risk factors, including hypertension, diabetes mellitus, and dyslipidemia, were less frequent in young adults than in non-young adults, the prevalence of diabetes mellitus and dyslipidemia in young adults aged >40 years were comparable to those of non-young adults. Lifestyle-related risk factors such as smoking, drinking, and obesity were more frequent in young adults than in non-young adults. As young adults became older, the proportions of cardioembolism and stroke of other determined etiologies decreased, but those of large-artery atherosclerosis and small-vessel occlusion increased. Some embolic sources (high-risk sources: arterial myxoma, dilated cardiomyopathy, and intracardiac thrombus; medium-risk sources: atrial septal defect, nonbacterial thrombotic endocarditis, patent foramen ovale, and left ventricular hypokinesis) and uncommon causes (vascular diseases: reversible cerebral vasoconstriction syndrome, moyamoya disease, other vascular causes, arterial dissection, and cerebral venous thrombosis; hematologic diseases: antiphospholipid syndrome and protein S deficiency) were more prevalent in young adults than in non-young adults, and these trends decreased with age. Conclusions Certain embolic sources and uncommon causes may be etiologically important causes of ischemic stroke in young adults. However, the contribution of conventional vascular risk factors and lifestyle-related risk factors is not negligible with advancing age, even in young adults.

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  • Relationship between platelet aggregation and stroke risk after percutaneous coronary intervention: a PENDULUM analysis Reviewed International journal

    Matsumaru Y, Kitazono T, Kadota K, Nakao K, Nakagawa Y, Shite J, Yokoi H, Kozuma K, Tanabe K, Akasaka T, Shinke T, Ueno T, Hirayama A, Uemura S, Kuroda T, Takita A, Harada A, Iijima R, Murakami Y, Saito S, Nakamura M

    Heart Vessels   2022.6

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  • Protective Roles of Xenotropic and Polytropic Retrovirus Receptor 1 (XPR1) in Uremic Vascular Calcification. Reviewed International journal

    Arase H, Yamada S, Torisu K, Tokumoto M, Taniguchi M, Tsuruya K, Nakano T, Kitazono T

    Calcif Tissue Int   2022.6

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  • Delayed administration of epinephrine is associated with worse neurological outcomes in patients with out-of-hospital cardiac arrest and initial pulseless electrical activity: insight from the nationwide multicentre observational JAAM-OHCA (Japan Association for Acute Medicine) registry Reviewed International journal

    Enzan N, Hiasa KI, Ichimura K, Nishihara M, Iyonaga T, Shono Y, Tohyama T, Funakoshi K, Kitazono T, Tsutsui H

    Eur Heart J Acute Cardiovasc Care   2022.6

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  • Relationship of coffee consumption with a decline in kidney function among patients with type 2 diabetes: The Fukuoka Diabetes Registry Reviewed International journal

    Komorita Y, Ohkuma T, Iwase M, Fujii H, Ide H, Oku Y, Higashi T, Oshiro A, Sakamoto W, Yoshinari M, Nakamura U, Kitazono T

    J Diabetes Investig   2022.6

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  • Association Between Diabetes and Gray Matter Atrophy Patterns in a General Older Japanese Population: The Hisayama Study Reviewed International journal

    Hirabayashi N, Hata J, Furuta Y, Ohara T, Shibata M, Hirakawa Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Ninomiya T

    Diabetes Care   2022.6

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  • Serum Alkaline Phosphatase Levels and Increased Risk of Brain Hemorrhage in Hemodialysis Patients: The Q-Cohort Study Reviewed International journal

    Kitamura H, Yamada S, Hiyamuta H, Yotsueda R, Taniguchi M, Tokumoto M, Tsuruya K, Nakano T, Kitazono T

    J Atheroscler Thromb   2022.6

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  • Relationship between platelet aggregation and stroke risk after percutaneous coronary intervention: a PENDULUM analysis Reviewed International journal

    Matsumaru Y, Kitazono T, Kadota K, Nakao K, Nakagawa Y, Shite J, Yokoi H, Kozuma K, Tanabe K, Akasaka T, Shinke T, Ueno T, Hirayama A, Uemura S, Kuroda T, Takita A, Harada A, Iijima R, Murakami Y, Saito S, Nakamura M

    Heart Vessels   2022.6

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  • Association of Inner Retinal Thickness with Prevalent Dementia and Brain Atrophy in a General Older Population

    Ueda, E; Hirabayashi, N; Ohara, T; Hata, J; Honda, T; Fujiwara, K; Furuta, Y; Shibata, M; Hashimoto, S; Nakamura, S; Nakazawa, T; Nakao, T; Kitazono, T; Ninomiya, T; Sonoda, KH

    OPHTHALMOLOGY SCIENCE   2 ( 2 )   100157   2022.6   ISSN:2666-9145

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    Purpose: To assess the association of inner retinal thickness with prevalent dementia and regional brain atrophy in a general older population of Japanese. Design: Population-based, cross-sectional study. Participants: A total of 1078 residents aged 65 years or older who participated in an eye examination, a comprehensive survey of dementia, and brain magnetic resonance imaging scanning in 2017. Methods: The thicknesses of the inner retinal layers, namely, the ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL)—were measured by swept-source OCT (SS-OCT). The association of these retinal thicknesses with the risk of the presence of dementia was estimated using restricted cubic splines and logistic regression models. Regional brain volumes were estimated separately by applying 2 different methods: voxel-based morphometry (VBM) and analysis by FreeSurfer software. The associations of GC-IPL and RNFL thickness with each brain regional volume were analyzed using multiple regression analysis. Main Outcome Measure: Prevalent dementia and regional brain atrophy. Results: Among the study participants, 61 participants (5.7%) were diagnosed with dementia. The likelihood of the presence of dementia significantly increased with lower GC-IPL thickness after adjusting for potential confounders (odds ratio, 1.62 [95% confidence interval, 1.30–2.01] per 1 standard deviation decrement in the GC-IPL thickness), but no significant association was observed with RNFL thickness. In the VBM analyses with the multivariable adjustment, lower GC-IPL thickness was significantly associated with lower volume of known brain regions related to cognitive functions (i.e., the hippocampus, amygdala, entorhinal area, and parahippocampal gyrus) and visual functions (i.e., the cuneus, lingual gyrus, and thalamus). Meanwhile, the volume of the thalamus significantly decreased with lower RNFL thickness, but none of the brain regions related to cognitive function exhibited a volume change in association with RNFL thickness. The sensitivity analysis using FreeSurfer analysis also showed that lower GC-IPL thickness was significantly associated with lower regional brain volume/intracranial volume of the hippocampus, amygdala, cuneus, lingual gyrus, and thalamus. Conclusions: Our findings suggest that the measurement of GC-IPL thickness by SS-OCT, which is a noninvasive, convenient, and reproducible method, might be useful for identifying high-risk individuals with dementia.

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  • Association Between Diabetes and Gray Matter Atrophy Patterns in a General Older Japanese Population: The Hisayama Study

    Hirabayashi, N; Hata, J; Furuta, Y; Ohara, T; Shibata, M; Hirakawa, Y; Yamashita, F; Yoshihara, K; Kitazono, T; Sudo, N; Ninomiya, T

    DIABETES CARE   45 ( 6 )   1364 - 1371   2022.6   ISSN:0149-5992 eISSN:1935-5548

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    OBJECTIVE To examine the association between diabetes and gray matter atrophy patterns in a general older Japanese population. RESEARCH DESIGN AND METHODS In 2012, a total of 1,189 community-dwelling Japanese aged ≥65 years underwent brain MRI scans. Regional gray matter volumes (GMV) and intracranial volume (ICV) were measured by applying voxel-based morphometry (VBM) methods. The associations of diabetes and related parameters with the regional GMV/ICV were examined using an ANCOVA. The regional gray matter atrophy patterns in the subjects with diabetes or elevated fasting plasma glucose (FPG) or 2-h postload glucose (2hPG) levels were investigated using VBM. RESULTS Subjects with diabetes had significantly lower mean values of GMV/ICV in the frontal lobe, temporal lobe, insula, deep gray matter structures, and cerebellum than subjects without diabetes after adjusting for potential confounders. A longer duration of diabetes was also significantly associated with lower mean values of GMV/ICV in these brain regions. The multivariable-adjusted mean values of the temporal, insular, and deep GMV/ICV decreased significantly with elevating 2hPG levels, whereas higher FPG levels were not significantly associated with GMV/ICV of any brain regions. In the VBM analysis, diabetes was associated with gray matter atrophy in the bilateral superior temporal gyri, right middle temporal gyrus, left inferior temporal gyrus, right middle frontal gyrus, bilateral thalami, right caudate, and right cerebellum. CONCLUSIONS The current study suggests that a longer duration of diabetes and elevated 2hPG levels are significant risk factors for gray matter atrophy in various brain regions.

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  • 2型糖尿病患者におけるコーヒー摂取と腎機能低下との関連 Fukuoka Diabetes Registry(Relationship of coffee consumption with a decline in kidney function among patients with type 2 diabetes: The Fukuoka Diabetes Registry)

    Komorita Yuji, Ohkuma Toshiaki, Iwase Masanori, Fujii Hiroki, Ide Hitoshi, Oku Yutaro, Higashi Taiki, Oshiro Ayaka, Sakamoto Wakako, Yoshinari Masahito, Nakamura Udai, Kitazono Takanari

    Journal of Diabetes Investigation   13 ( 6 )   1030 - 1038   2022.6   ISSN:2040-1116

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    Fukuoka Diabetes Registryに登録された2型糖尿病患者3805例(男性2112例、平均64.2歳、eGFR>60mL/min/1.73m2)を対象とした前向き研究を実施し、コーヒー摂取と推定糸球体機能率(eGFR)低下との関連について検討した。ベースラインでのコーヒー摂取頻度(全く飲まない、1日1杯未満、1日1杯、1日2杯以上)を評価した。エンドポイントは追跡期間中におけるeGFR<60mL/min/1.73m2への低下とした。追跡期間中央値は5.3年、追跡完遂率は97.6%であった。その結果、追跡期間中に840例でeGFR低下が認められた。コーヒー摂取量が高いほど、eGFR低下リスクは減少していた。コーヒーを摂取しない場合と比較した結果、コーヒー摂取頻度1日1杯未満、1日1杯、1日2杯以上の多変量調整ハザード比は0.77、0.77、0.75であった(P for trend 0.01)。この傾向は、ベースラインのeGFRおよびアルブミン尿などの潜在的交絡因子調整後も維持された。1年あたりのeGFR平均変化量はコーヒー摂取なし、1日1杯未満、1日1杯、1日2杯以上でそれぞれ-2.16mL/min/1.73m2、-1.89mL/min/1.73m2、-1.80mL/min/1.73m2、-1.78mL/min/1.73m2であった(P for trend 0.03)。以上から、2型糖尿病患者におけるコーヒー摂取はeGFR低下リスクを有意に低下させることが示された。

  • Practical "1-2-3-4-Day" Rule for Starting Direct Oral Anticoagulants After Ischemic Stroke With Atrial Fibrillation: Combined Hospital-Based Cohort Study Reviewed International journal

    Stroke   2022.5

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  • Comparison of the predictability of serum creatinine-based surrogates of skeletal muscle mass for all-cause mortality in patients receiving hemodialysis: creatinine generation rate and creatinine index Reviewed International journal

    Yamada S, Arase H, Taniguchi M, Kitazono T, Nakano T

    Clin Exp Nephrol   2022.5

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  • The Compositional Structure of the Small Intestinal Microbial Community via Balloon-Assisted Enteroscopy Reviewed International journal

    Nagasue T, Hirano A, Torisu T, Umeno J, Shibata H, Moriyama T, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Esaki M, Kitazono T.

    Digestion   2022.4

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  • Usefulness of urinary tubule injury markers for predicting progression of renal dysfunction in patients with type 2 diabetes and albuminuria: The Fukuoka Diabetes Registry Reviewed International journal

    Ide H, Iwase M, Ohkuma T, Fujii H, Komorita Y, Oku Y, Higashi T, Yoshinari M, Nakamura U, Kitazono T

    Diabetes Res Clin Pract   2022.4

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  • Association of Inner Retinal Thickness with Prevalent Dementia and Brain Atrophy in a General Older Population: The Hisayama Study Reviewed International journal

    Ueda E, Hirabayashi N, Ohara T, Hata J, Honda T, Fujiwara K, Furuta Y, Shibata M, Hashimoto S, Nakamura S, Nakazawa T, Nakao T, Kitazono T, Ninomiya T, Sonoda KH

    Ophthalmol Sci   2022.4

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  • One-year clinical efficacy and safety of indigo naturalis for active ulcerative colitis: a real-world prospective study Reviewed International journal

    Matsuno Y, Torisu T, Umeno J, Shibata H, Hirano A, Fuyuno Y, Okamoto Y, Fujioka S, Kawasaki K, Moriyama T, Nagasue T, Zeze K, Hirakawa Y, Kawatoko S, Koga Y, Oda Y, Esaki M, Kitazono T

    Intest Res   2022.4

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  • Association of daily sleep duration with the incident dementia by serum soluble TREM2 in a community Reviewed International journal

    Ohara T, Hata J, Tanaka M, Honda T, Yamakage H, Inoue T, Hirakawa Y, Kusakabe T, Shibata M, Kitazono T, Nakao T, Satoh-Asahara N, Ninomiya T

    J Am Geriatr Soc   2022.4

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  • Association of daily sleep duration with the incident dementia by serum soluble TREM2 in a community

    Ohara, T; Hata, J; Tanaka, M; Honda, T; Yamakage, H; Inoue, T; Hirakawa, Y; Kusakabe, T; Shibata, M; Kitazono, T; Nakao, T; Satoh-Asahara, N; Ninomiya, T

    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY   70 ( 4 )   1147 - 1156   2022.4   ISSN:0002-8614 eISSN:1532-5415

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    Background: Little is known about the influence of serum level of soluble triggering receptor expressed on myeloid cells 2 (sTREM2), which is a soluble type of an innate immune receptor expressed on the microglia, on the association of the daily sleep duration with the risk of dementia. Methods: A total of 1230 Japanese community-residents aged 60 and older without dementia were followed prospectively for 10 years (2002–2012). Serum sTREM2 levels were divided into two groups using the median value (334.8 pg/ml). Self-reported daily sleep duration was grouped into three categories of <5.0, 5.0–7.9, and ≥8.0 h. A Cox proportional hazards model was used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) of daily sleep duration on the risk of dementia according to serum sTREM2 levels. Results: During the follow-up, 262 subjects developed dementia. In subjects with low serum sTREM2 levels, subjects with ≥8.0 h of daily sleep had a significantly greater risk of dementia (multivariable-adjusted HR 2.05 [95% CI 1.32–3.19]) than those with 5.0–7.9 h of daily sleep, but those with <5.0 h did not. In contrast, the risk of dementia increased significantly in subjects with both <5.0 (1.95 [1.03–3.68]) and ≥8.0 h of daily sleep (1.48 [1.06–2.07]) in the subjects with high serum sTREM2 levels. Conclusions: The influence of daily sleep duration on risk of dementia differed according to serum sTREM2 levels in the older Japanese population. Short daily sleep may be associated with greater risk of dementia only in subjects with a high serum sTREM2 level.

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  • Multiple-region grey matter atrophy as a predictor for the development of dementia in a community: the Hisayama Study. Reviewed International journal

    Nakazawa T, Ohara T, Hirabayashi N, Furuta Y, Hata J, Shibata M, Honda T, Kitazono T, Nakao T, Ninomiya T

    J Neurol Neurosurg Psychiatry   2022.3

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  • Long-term association of vegetable and fruit intake with risk of dementia in Japanese older adults: the Hisayama study Reviewed International journal

    Kimura Y, Yoshida D, Ohara T, Hata J, Honda T, Hirakawa Y, Shibata M, Oishi E, Sakata S, Furuta Y, Chen S, Uchida K, Nakao T, Kitazono T, Ninomiya T

    BMC Geriatr   2022.3

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  • Impact of three major risk factors on clinical outcomes in patients with nonvalvular atrial fibrillation receiving rivaroxaban: Sub-analysis from the XAPASS study Reviewed International journal

    Ikeda T, Ogawa S, Kitazono T, Nakagawara J, Minematsu K, Miyamoto S, Murakawa Y, Tachiiri M, Okayama Y, Sunaya T, Hirano K, Hayasaki T

    J Arrhythm   2022.3

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  • Changes in Body Weight and Concurrent Changes in Cardiovascular Risk Profiles in Community Residents in Japan: the Hisayama Study

    Honda Takanori, Ishida Yuki, Oda Masaaki, Noguchi Kenichi, Chen Sanmei, Sakata Satoko, Oishi Emi, Furuta Yoshihiko, Yoshida Daigo, Hirakawa Yoichiro, Hata Jun, Kitazono Takanari, Ninomiya Toshiharu

    Journal of Atherosclerosis and Thrombosis   29 ( 2 )   252 - 267   2022.2   ISSN:13403478 eISSN:18803873

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    <p><b>Aim:</b> We investigated the influence of weight change on concurrent changes in predicted cardiovascular disease (CVD) risk and individual CVD risk factors over time. </p><p><b>Methods:</b> A total of 2,140 community-dwellers aged 40–74 years participated in both 2002 and 2007 health examinations. Obesity was defined as body mass index ≥ 25 kg/m<sup>2</sup>. Weight trajectories were classified as: “stable obese” (obese at both examinations), “obese to nonobese” (obese in 2002 but nonobese in 2007), “nonobese to obese” (nonobese in 2002 but obese in 2007), or “stable nonobese” (nonobese at both examinations). We compared changes in the model-predicted risk for CVD and individual CVD risk factors across weight-change categories. </p><p><b>Results:</b> The predicted risk for CVD increased during 5 years in all groups; the increment in the predicted risk for CVD was smallest in the obese to nonobese participants and steepest in the nonobese to obese subjects. Compared with the stable obese participants, the obese to nonobese participants had greater favorable changes in waist circumferences, blood pressure, fasting plasma glucose, serum high-density lipoprotein cholesterol, serum triglycerides, and liver enzymes. For all these parameters, opposite trends were observed when comparing the nonobese to obese participants with the stable nonobese group. </p><p><b>Conclusions:</b> We demonstrated the favorable association of losing weight in obese people and avoiding excessive weight gain in nonobese people with global risk of future CVD and individual CVD risk factors in a real-world setting. The findings could improve behavioral lifestyle interventions that provide information on the health consequences of weight change at health checkups. </p>

    DOI: 10.5551/jat.59394

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    CiNii Research

  • Development and Validation of a Risk Prediction Model for Atherosclerotic Cardiovascular Disease in Japanese Adults: The Hisayama Study. Reviewed International journal

    Honda T, Chen S, Hata J, Yoshida D, Hirakawa Y, Furuta Y, Shibata M, Sakata S, Kitazono T, Ninomiya T

    J Atheroscler Thromb   2022.2

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  • Serum Uric Acid Levels and Nephrosclerosis in a Population-Based Autopsy Study: The Hisayama Study. Reviewed International journal

    Maki K, Hata J, Sakata S, Oishi E, Furuta Y, Nakano T, Oda Y, Kitazono T, Ninomiya T

    Am J Nephrol   2022.2

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  • Long-Term Trends in The 5-Year Risk of Recurrent Stroke over A Half Century in A Japanese Community: The Hisayama Study Reviewed International journal

    Nakanishi Y, Furuta Y, Hata J, Yubi T, Oishi E, Sakata S, Hirakawa Y, Wakisaka Y, Ago T, Kitazono T, Ninomiya T

    J Atheroscler Thromb   2022.2

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  • Intravenous Alteplase at 0.6 mg/kg for Unknown Onset Stroke with Prior Antithrombotic Medication: THAWS Randomized Clinical Trial Reviewed International journal

    Koga M, Inoue M, Miwa K, Yoshimura S, Fukuda-Doi M, Aoki J, Asakura K, Kanzawa T, Ohtaki M, Kamiyama K, Yakushiji Y, Igarashi S, Doijiri R, Ito Y, Takagi Y, Sasaki M, Kitazono T, Kimura K, Minematsu K, Yamamoto H, Toyoda K; THAWS trial investigators

    J Atheroscler Thromb   2022.2

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  • Lymphoid and myeloid proliferative disorders associated with inflammatory bowel disease: a clinicopathological study of 15 cases Reviewed International journal

    Hori Y, Yamamoto H, Kawatoko S, Nozaki Y, Torisu T, Kato K, Koga Y, Miyoshi H, Ohshima K, Tateishi Y, Nakamura S, Kitazono T, Oda Y

    Hum Pathol   2022.2

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  • Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016 Reviewed International journal

    Kurogi A, Onozuka D, Hagihara A, Nishimura K, Kada A, Hasegawa M, Higashi T, Kitazono T, Ohta T, Sakai N, Arai H, Miyamoto S, Sakamoto T, Iihara K; J-ASPECT Study Collaborators

    Sci Rep   2022.2

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  • Incidence of end-stage renal disease and risk factors for progression of renal dysfunction in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry . Reviewed International journal

    Iwase M, Ide H, Ohkuma T, Fujii H, Komorita Y, Yoshinari M, Oku Y, Higashi T, Nakamura U, Kitazono T

    Clin Exp Nephrol   2022.2

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  • Changes in Body Weight and Concurrent Changes in Cardiovascular Risk Profiles in Community Residents in Japan: the Hisayama Study. Reviewed International journal

    Honda T, Ishida Y, Oda M, Noguchi K, Chen S, Sakata S, Oishi E, Furuta Y, Yoshida D, Hirakawa Y, Hata J, Kitazono T, Ninomiya T

    J Atheroscler Thromb   2022.2

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  • 2型糖尿病の日本人患者における末期腎臓病の発生率と腎機能障害進行の危険因子 福岡県糖尿病患者データベース研究(Incidence of end-stage renal disease and risk factors for progression of renal dysfunction in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry)

    Iwase Masanori, Ide Hitoshi, Ohkuma Toshiaki, Fujii Hiroki, Komorita Yuji, Yoshinari Masahito, Oku Yutaro, Higashi Taiki, Nakamura Udai, Kitazono Takanari

    Clinical and Experimental Nephrology   26 ( 2 )   122 - 131   2022.2   ISSN:1342-1751

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    Language:English   Publisher:(一社)日本腎臓学会  

    2型糖尿病罹患の日本人集団での末期腎臓病の発生率と腎機能障害進行の危険因子を前向きに追跡調査した。2008年4月~2010年10月に多施設共同前向き研究(福岡県糖尿病患者データベース研究;Fukuoka Diabetes Registry)へ登録された2型糖尿病の外来成人患者で、少なくとも初年度は追跡できた4904名(男性57%、平均65±10歳)を本研究に組み入れた。末期腎臓病の発生率は4.1/1000人-年、全死因死亡率は12.3/1000人-年であった。推算糸球体濾過量(eGFR)が30mL/分/1.73m2の集団に限定すると、上記の両率は同順で176.6/1000人-年および57.4/1000人-年といずれも上昇した。ベースラインから5年後までにeGFRの減少率が30%を上回った患者の割合は16.4%であり、eGFRの平均年次減少率は1.84mL/分/1.73m2/年であった。腎機能障害の進行と有意に関連していた因子は、高齢、血糖コントロール不良、血圧、アルブミン尿、eGFR、心血管疾患の既往、ライフスタイル要因(BMI、食物繊維摂取不足、ナトリウム摂取増加、定期的な運動習慣の欠如)、抑うつ症状であった。本前向き研究の結果から、日本人2型糖尿病患者で高かった末期腎臓病の発生率を抑制するには、様々な危険因子に対する多面的介入が重要であることが強調された。

  • Association of the nutritional risk index for Japanese hemodialysis patients with long-term mortality: The Q-Cohort Study. Reviewed International journal

    Shimamoto S, Yamada S, Hiyamuta H, Arase H, Taniguchi M, Tsuruya K, Nakano T, Kitazono T

    Clin Exp Nephrol   2022.1

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  • Malnutrition-Inflammation Complex Syndrome and Bone Fractures and Cardiovascular Disease Events in Patients Undergoing Hemodialysis: The Q-Cohort Study Reviewed International journal

    Yamada S, Arase H, Yoshida H, Kitamura H, Tokumoto M, Taniguchi M, Hirakata H, Tsuruya K, Nakano T, Kitazono T

    Kidney Med   2022.1

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  • Day-by-Day Blood Pressure Variability in the Subacute Stage of Ischemic Stroke and Long-Term Recurrence Reviewed International journal

    Fukuda K, Matsuo R, Kamouchi M, Kiyuna F, Sato N, Nakamura K, Hata J, Wakisaka Y, Ago T, Imaizumi T, Kai H, Kitazono T; FSR Investigators

    Stroke   2022.1

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  • Sex differences in the 10-year survival of patients undergoing maintenance hemodialysis in the Q-Cohort Study. Reviewed International journal

    Tsujikawa H, Yamada S, Hiyamuta H, Taniguchi M, Tsuruya K, Torisu K, Nakano T, Kitazono T

    Sci Rep   2022.1

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  • Twenty-Year Change in Severity and Outcome of Ischemic and Hemorrhagic Strokes. Reviewed International journal

    Toyoda K, Yoshimura S, Nakai M, Koga M, Sasahara Y, Sonoda K, Kamiyama K, Yazawa Y, Kawada S, Sasaki M, Terasaki T, Miwa K, Koge J, Ishigami A, Wada S, Iwanaga Y, Miyamoto Y, Minematsu K, Kobayashi S; Japan Stroke Data Bank Investigators (Kitazono T)

    JAMA Neurol   2022.1

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  • Association of the nutritional risk index for Japanese hemodialysis patients with long-term mortality: The Q-Cohort Study

    Shimamoto, S; Yamada, S; Hiyamuta, H; Arase, H; Taniguchi, M; Tsuruya, K; Nakano, T; Kitazono, T

    CLINICAL AND EXPERIMENTAL NEPHROLOGY   26 ( 1 )   59 - 67   2022.1   ISSN:1342-1751 eISSN:1437-7799

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    Background: Protein-energy wasting (PEW) is a risk factor for mortality in patients undergoing hemodialysis. Recently, a nutritional risk index for Japanese hemodialysis patients (NRI-JH) has been proposed as a surrogate index of PEW. However, no study has determined the association of the NRI-JH with long-term mortality in patients undergoing hemodialysis. Furthermore, the validity of the NRI-JH has not been confirmed. Methods: In total, 3046 patients undergoing hemodialysis and registered in the Q-Cohort Study were followed up for 10 years. The NRI-JH was calculated on the basis of body mass index and serum levels of albumin, total cholesterol, and creatinine. The patients were divided into four groups according to the NRI-JH scores: 0–3 (G1, n = 1343), 4–7 (G2, n = 1136), 8–10 (G3, n = 321), and 11–13 (G4, n = 246). We examined the association between the NRI-JH and the 4-year and 10-year risks of all-cause, cardiovascular, and infection-related deaths using the Cox proportional hazards model. Results: During the follow-up period, 647 patients died during the first 4 years, and 1503 patients died within 10 years. The 4-year prognosis was analyzed and compared with the lowest NRI-JH score group. Multivariable-adjusted hazard ratios (95% confidence intervals) for all-cause death were 1.93 (1.57–2.38), 2.68 (2.05–3.50), and 3.16 (2.40–4.16) in the G2, G3, and G4 groups, respectively. Similarly, a higher NRI-JH score was associated with an increased risk of cardiovascular and infection-related deaths. Conclusion: A higher NRI-JH score was associated with an increased risk of long-term mortality in patients undergoing maintenance hemodialysis. Trial registration: The study protocol was registered in the University Hospital Medical Information Network (UMIN) clinical trial registry (UMIN ID: 000000556).

    DOI: 10.1007/s10157-021-02124-6

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  • Risk of Rebleeding in Patients with Small Bowel Vascular Lesions. Reviewed International journal

    Harada A, Torisu T, Fujioka S, Yoshida Y, Okamoto Y, Fuyuno Y, Hirano A, Umeno J, Torisu K, Moriyama T, Esaki M, Kitazono T

    Intern Med   2021.12

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  • Sex Differences in the Risk of 30-Day Death After Acute Ischemic Stroke. Reviewed International journal

    Irie F, Matsuo R, Nakamura K, Wakisaka Y, Ago T, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators

    Neurol Clin Pract   2021.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Constipation and diabetic kidney disease: The Fukuoka Diabetes Registry. Reviewed International journal

    Ohkuma T, Iwase M, Fujii H, Ide H, Komorita Y, Yoshinari M, Oku Y, Higashi T, Oshiro A, Nakamura U, Kitazono T.

    Clin Exp Nephrol   2021.11

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  • Association between the urinary sodium-to-potassium ratio and renal outcomes in patients with chronic kidney disease: a prospective cohort study. Reviewed International journal

    Matsukuma Y, Nakayama M, Tsuda S, Fukui A, Yoshitomi R, Tsuruya K, Nakano T, Kitazono T

    Hypertens Res   2021.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Polypharmacy and bone fracture risk in patients with type 2 diabetes: The Fukuoka Diabetes Registry. Reviewed International journal

    Komorita Y, Ohkuma T, Iwase M, Fujii H, Oku Y, Higashi T, Oshiro A, Sakamoto W, Yoshinari M, Nakamura U, Kitazono T

    Diabetes Res Clin Pract   2021.11

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  • Left Atrial Appendage Flow Velocity and Multiple Infarcts in Cryptogenic Stroke. Reviewed International journal

    Tokunaga K, Hashimoto G, Mizoguchi T, Mori K, Shijo M, Jinnouchi J, Kuwashiro T, Yasaka M, Kitazono T, Okada Y

    Cerebrovasc Dis   2021.11

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  • Autophagy gene ATG7 regulates albumin transcytosis in renal tubule epithelial cells. Reviewed International journal

    Uchida Y, Torisu K, Ueki K, Tsuruya K, Nakano T, Kitazono T

    Am J Physiol Renal Physiol   2021.11

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  • Association between Multimorbidity and Kidney Function among Patients with Non-Dialysis-Dependent CKD. Reviewed International journal

    Tanaka S, Nakano T, Hiyamuta H, Tsuruya K, Kitazono T; FKR Study Collaboration Group

    J Atheroscler Thromb   2021.10

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  • Midlife and late-life diabetes and sarcopenia in a general older Japanese population: The Hisayama Study. Reviewed International journal

    Nakamura K, Yoshida D, Honda T, Hata J, Shibata M, Hirakawa Y, Furuta Y, Kishimoto H, Ohara T, Chen S, Kitazono T, Nakashima Y, Ninomiya T

    J Diabetes Investig   2021.10

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  • Associations Between Surrogates of Skeletal Muscle Mass and History of Bone Fracture in Patients with Chronic Kidney Disease: The Fukuoka Kidney disease Registry (FKR) Study. Reviewed International journal

    Yamada S, Tanaka S, Arase H, Hiyamuta H, Yoshizumi E, Tokumoto M, Nakano T, Tsuruya K, Kitazono T

    Calcif Tissue Int   2021.10

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  • Regional Disparity of Reperfusion Therapy for Acute Ischemic Stroke in Japan: A Retrospective Analysis of Nationwide Claims Data from 2010 to 2015. Reviewed International journal

    Maeda M, Fukuda H, Matsuo R, Ago T, Kitazono T, Kamouchi M

    J Am Heart Assoc   2021.10

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  • Causes of death in patients undergoing maintenance hemodialysis in Japan: 10-year outcomes of the Q-Cohort Study. Reviewed International journal

    Hiyamuta H, Yamada S, Taniguchi M, Nakano T, Tsuruya K, Kitazono T

    Clin Exp Nephrol   2021.10

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  • Gastric microbiota in patients with Helicobacter pylori-negative gastric MALT lymphoma. Reviewed International journal

    Tanaka T, Matsuno Y, Torisu T, Shibata H, Hirano A, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Moriyama T, Esaki M, Kitazono T

    Medicine (Baltimore)   2021.9

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  • Intraplaque high-intensity signal on time-of-flight magnetic resonance angiography and restenosis after carotid artery stenting. Reviewed International journal

    Tokunaga K, Tokunaga S, Hara K, Yasaka M, Okada Y, Kitazono T, Tsumoto T

    J Neurosurg   2021.9

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  • Serum NT-proBNP levels and histopathological myocardial fibrosis in autopsied cases from a Japanese community: The Hisayama Study. Reviewed International journal

    Sasaki T, Izumaru K, Hata J, Sakata S, Oishi E, Nagata T, Tsuboi N, Oda Y, Kitazono T, Yokoo T, Ninomiya T

    J Cardiol   2021.9

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  • Development of a risk prediction model for incident hypertension in Japanese individuals: the Hisayama Study. Reviewed International journal

    Oishi E, Hata J, Honda T, Sakata S, Chen S, Hirakawa Y, Yoshida D, Shibata M, Ohara T, Furuta Y, Kitazono T, Ninomiya T

    Hypertens Res   2021.9

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  • Ischemic stroke, hemorrhage, and mortality in patients with non-valvular atrial fibrillation and renal dysfunction treated with rivaroxaban: sub-analysis of the EXPAND study Reviewed International journal

    Atarashi H, Uchiyama S, Inoue H, Kitazono T, Yamashita T, Shimizu W, Ikeda T, Kamouchi M, Kaikita K, Fukuda K, Origasa H, Shimokawa H

    Heart Vessels   2021.9

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  • Adding Thiopurine After Loss of Response to Infliximab Versus Early Combination in Treating Crohn's Disease: A Retrospective Study. Reviewed International journal

    Zeze K, Hirano A, Torisu T, Esaki M, Moriyama T, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Kitazono T

    Dig Dis Sci   2021.9

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  • Impact of Physician Volume and Specialty on In-Hospital Mortality of Ischemic and Hemorrhagic Stroke. Reviewed International journal

    Nishimura K, Ogasawara K, Kitazono T, Iihara K; J-ASPECT Study Collaborators

    Circ J   2021.9

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  • β-Cell Function and Clinical Outcome in Nondiabetic Patients With Acute Ischemic Stroke. Reviewed International journal

    2021.8

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  • Comparison of the contributions of impaired beta cell function and insulin resistance to the development of type 2 diabetes in a Japanese community: the Hisayama Study. Reviewed International journal

    Yoshinari M, Hirakawa Y, Hata J, Higashioka M, Honda T, Yoshida D, Mukai N, Nakamura U, Kitazono T, Ninomiya T

    Diabetologia   2021.8

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  • Subclinical hypothyroidism is independently associated with poor renal outcomes in patients with chronic kidney disease. Reviewed International journal

    Tsuda S, Nakayama M, Matsukuma Y, Yoshitomi R, Haruyama N, Fukui A, Nakano T, Tsuruya K, Kitazono T

    Endocrine   2021.7

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  • Serum High-Sensitivity C-Reactive Protein Levels and the Development of Atrial Fibrillation in a General Japanese Population - The Hisayama Study. Reviewed International journal

    Yoshikawa T, Hata J, Sakata S, Nagata T, Hirakawa Y, Hirooka Y, Tsutsui H, Kitazono T, Ninomiya T

    Circ J   2021.7

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  • Risk Prediction Model for Incident Atrial Fibrillation in a General Japanese Population - The Hisayama Study. Reviewed International journal

    Hata J, Nagata T, Sakata S, Oishi E, Furuta Y, Hirakawa Y, Honda T, Yoshida D, Kitazono T, Ninomiya T

    Circ J   2021.7

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  • Association of blood pressure after peritoneal dialysis initiation with the decline rate of residual kidney function in newly-initiated peritoneal dialysis patients. Reviewed International journal

    Kuroki Y, Hori K, Tsuruya K, Matsuo D, Mitsuiki K, Hirakata H, Nakano T, Kitazono T

    PLoS One   2021.7

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  • Ustekinumab Improves Active Crohn's Disease by Suppressing the T Helper 17 Pathway. Reviewed International journal

    Ihara Y, Torisu T, Miyawaki K, Umeno J, Kawasaki K, Hirano A, Fujioka S, Fuyuno Y, Matsuno Y, Sugio T, Sasaki K, Moriyama T, Akashi K, Kitazono T

    Digestion   2021.6

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  • Real-world safety and effectiveness of rivaroxaban using Japan-specific dosage during long-term follow-up in patients with atrial fibrillation: XAPASS. Reviewed International journal

    Ikeda T, Ogawa S, Kitazono T, Nakagawara J, Minematsu K, Miyamoto S, Murakawa Y, Iwashiro S, Okayama Y, Sunaya T, Hirano K, Hayasaki T

    PLoS One   2021.6

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  • High low-density lipoprotein cholesterol as an independent risk factor for coronary restenosis in hemodialysis patients undergoing percutaneous coronary interventions. Reviewed International journal

    Hasegawa S, Nakano T, Mukai Y, Matsukuma Y, Yotsueda R, Tsuchimoto A, Fujisaki K, Tsuruya K, Tsutsui H, Kitazono T

    Ther Apher Dial.   2021.6

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  • Prevalence and Mortality of Sarcopenia in a Community-dwelling Older Japanese Population: The Hisayama Study. Reviewed International journal

    Nakamura K, Yoshida D, Honda T, Hata J, Shibata M, Hirakawa Y, Furuta Y, Kishimoto H, Ohara T, Kitazono T, Nakashima Y, Ninomiya T

    J Epidemiol   2021.5

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  • Current status of the certification of long-term care insurance among individuals with dementia in a Japanese community: The Hisayama Study. Reviewed International journal

    Ohara T, Yoshida D, Hata J, Shibata M, Honda T, Furuta Y, Hirabayashi N, Kitazono T, Nakao T, Ninomiya T

    Psychiatry Clin Neurosci   2021.5

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  • Relationship between casual serum triglyceride levels and the development of hypertension in Japanese. Reviewed International journal

    Tomita Y, Sakata S, Arima H, Yamato I, Ibaraki A, Ohtsubo T, Matsumura K, Fukuhara M, Goto K, Kitazono T

    J Hypertens   2021.4

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  • Urinary N-terminal pro-B-type natriuretic peptide as a biomarker for cardiovascular events in a general Japanese population: the Hisayama Study. Reviewed International journal

    Yamasaki K, Hata J, Ide T, Nagata T, Sakata S, Yoshida D, Honda T, Hirakawa Y, Nakano T, Kitazono T, Tsutsui H, Ninomiya T

    Environ Health Prev Med   2021.4

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  • Dietary fiber intake and risk of type 2 diabetes in a general Japanese population: The Hisayama Study. Reviewed International journal

    Kimura Y, Yoshida D, Hirakawa Y, Hata J, Honda T, Shibata M, Sakata S, Uchida K, Kitazono T, Ninomiya T

    J Diabetes Investig   2021.4

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  • Clopidogrel response predicts thromboembolic events associated with coil embolization of unruptured intracranial aneurysms: A prospective cohort study. Reviewed International journal

    Higashi E, Matsumoto S, Nakahara I, Hatano T, Ishii A, Sadamasa N, Ohta T, Ishihara T, Tokunaga K, Ando M, Chihara H, Furuta K, Hashimoto T, Tanaka K, Sonoda K, Koge J, Takita W, Hashikawa T, Funakoshi Y, Kondo D, Kamata T, Tsujimoto A, Matsushita T, Murai H, Matsuo K, Kitazono T, Kira J

    PLoS One   2021.4

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  • Prevalence of bone fracture and its association with severe hypoglycemia in Japanese patients with type 1 diabetes. Reviewed International journal

    Komorita Y, Minami M, Maeda Y, Yoshioka R, Ohkuma T, Kitazono T

    BMJ Open Diabetes Res Care   2021.4

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  • Relationship between serum lipid concentrations and impaired renal function in patients with chronic kidney disease: the Fukuoka Kidney Disease Registry Study. Reviewed International journal

    Nakano T, Tanaka S, Tsuruya K, Kitazono T

    Clin Exp Nephrol   2021.4

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  • Pre-Stroke Cholinesterase Inhibitor Treatment Is Beneficially Associated with Functional Outcome in Patients with Acute Ischemic Stroke and Pre-Stroke Dementia: The Fukuoka Stroke Registry. Invited International journal

    Wakisaka Y, Matsuo R, Nakamura K, Ago T, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators

    Cerebrovasc Dis   2021.4

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  • Impact of Multivascular Disease on Cardiovascular Mortality and Morbidity in Patients Receiving Hemodialysis: Ten-Year Outcomes of the Q-Cohort Study. Reviewed International journal

    Tanaka S, Nakano T, Hiyamuta H, Taniguchi M, Tokumoto M, Masutani K, Ooboshi H, Tsuruya K, Kitazono T

    J Atheroscler Thromb   2021.4

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  • Stronger Effect of Azilsartan on Reduction of Proteinuria Compared to Candesartan in Patients with CKD: A Randomized Crossover Trial. Reviewed International journal

    Suehiro T, Tsuruya K, Yoshida H, Tsujikawa H, Yamada S, Tanaka S, Tsuchimoto A, Eriguchi M, Fujisaki K, Torisu K, Nakano T, Kitazono T

    Kidney Blood Press Res   2021.4

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  • Association between geriatric nutritional risk index and stroke risk in hemodialysis patients: 10-Years outcome of the Q-Cohort study. Reviewed International journal

    Tsuneyoshi S, Matsukuma Y, Kawai Y, Hiyamuta H, Yamada S, Kitamura H, Tanaka S, Taniguchi M, Tsuruya K, Nakano T, Kitazono T

    Atherosclerosis   2021.4

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  • Blood Pressure Level and Variability During Long-Term Prasugrel or Clopidogrel Medication After Stroke: PRASTRO-I. Reviewed International journal

    Toyoda K, Yamagami H, Kitagawa K, Kitazono T, Nagao T, Minematsu K, Uchiyama S, Tanahashi N, Matsumoto M, Nagata I, Nishikawa M, Nanto S, Shirai T, Abe K, Ikeda Y, Ogawa A; PRASTRO Trial Investigators*

    Stroke   2021.4

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  • Association of normalized protein catabolic rate (nPCR) with the risk of bone fracture in patients undergoing maintenance hemodialysis: The Q-Cohort Study. Reviewed International journal

    Ohnaka S, Yamada S, Tsujikawa H, Arase H, Taniguchi M, Tokumoto M, Tsuruya K, Nakano T, Kitazono T.

    Clin Nutr.   2021.3

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  • Association of normalized protein catabolic rate (nPCR) with the risk of bone fracture in patients undergoing maintenance hemodialysis: The Q-Cohort Study. Reviewed International journal

    Ohnaka S, Yamada S, Tsujikawa H, Arase H, Taniguchi M, Tokumoto M, Tsuruya K, Nakano T, Kitazono T

    Clin Nutr   2021.3

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  • Association between coffee and green tea intake and pneumonia among the Japanese elderly: a case-control study. Reviewed International journal

    Kondo K, Suzuki K, Washio M, Ohfuji S, Adachi S, Kan S, Imai S, Yoshimura K, Miyashita N, Fujisawa N, Maeda A, Fukushima W, Hirota Y; Pneumonia in Elderly People Study Group

    Sci Rep   2021.3

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  • High Serum Folate Concentrations Are Associated with Decreased Risk of Mortality among Japanese Adults. Reviewed International journal

    Chen S, Honda T, Hata J, Sakata S, Furuta Y, Yoshida D, Shibata M, Ohara T, Hirakawa Y, Oishi E, Kitazono T, Ninomiya T

    J Nutr   2021.3

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  • Efficacy and Safety of Prasugrel by Stroke Subtype: A Sub-Analysis of the PRASTRO-I Randomized Controlled Trial. Reviewed International journal

    Kitazono T, Toyoda K, Kitagawa K, Nagao T, Yamagami H, Uchiyama S, Tanahashi N, Matsumoto M, Minematsu K, Nagata I, Nishikawa M, Nanto S, Ikeda Y, Shirai T, Abe K, Ogawa A; PRASTRO-I Study Group.

    Thromb.   2021.2

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  • Incidence of stroke and its association with glycemic control and lifestyle in Japanese patients with type 2 diabetes mellitus: The Fukuoka diabetes registry. Reviewed International journal

    Iwase M, Komorita Y, Ohkuma T, Fujii H, Ide H, Yoshinari M, Oku Y, Higashi T, Nakamura U, Kitazono T

    Diabetes Res Clin Pract   2021.2

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  • Defecation frequency and glycemic control in patients with diabetes: The Fukuoka Diabetes Registry. Reviewed International journal

    Ohkuma T, Iwase M, Fujii H, Ide H, Komorita Y, Yoshinari M, Oku Y, Higashi T, Nakamura U, Kitazono T

    J Diabetes Complications   2021.2

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  • Magnetic Resonance Imaging-Guided Thrombolysis (0.6 mg/kg) Was Beneficial for Unknown Onset Stroke Above a Certain Core Size: THAWS RCT Substudy Reviewed International journal

    Toyoda K, Inoue M, Yoshimura S, Yamagami H, Sasaki M, Fukuda-Doi M, Kimura K, Asakura K, Miwa K, Kanzawa T, Ihara M, Kondo R, Shiozawa M, Ohtaki M, Kamiyama K, Itabashi R, Iwama T, Aoki J, Minematsu K, Yamamoto H, Koga M; THAWS trial investigators*.(Kitazono T).

    Stroke.   2021.1

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  • Day-by-Day Blood Pressure Variability in the Subacute Stage of Ischemic Stroke and Long-Term Recurrence. Reviewed International journal

    Fukuda K, Matsuo R, Kamouchi M, Kiyuna F, Sato N, Nakamura K, Hata J, Wakisaka Y, Ago T, Imaizumi T, Kai H, Kitazono T; FSR Investigators

    Stroke   2021.1

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  • Association between urinary salt excretion and albuminuria in Japanese patients with chronic kidney disease: the Fukuoka kidney disease registry study. Reviewed International journal

    Fukui A, Nakayama M, Tanaka S, Matsukuma Y, Yoshitomi R, Nakano T, Tsuruya K, Kitazono T

    Clin Exp Nephrol   2021.1

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  • The Association of Small Dense Low-Density Lipoprotein Cholesterol and Coronary Heart Disease in Subjects at High Cardiovascular Risk. Reviewed International journal

    Higashioka M, Sakata S, Honda T, Hata J, Shibata M, Yoshida D, Goto K, Kitazono T, Osawa H, Ninomiya T

    J Atheroscler Thromb   2021.1

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  • Development and validation of a risk score for the prediction of cardiovascular disease in living donor kidney transplant recipients. Reviewed International journal

    Ueki K, Tsuchimoto A, Matsukuma Y, Nakagawa K, Tsujikawa H, Masutani K, Tanaka S, Kaku K, Noguchi H, Okabe Y, Unagami K, Kakuta Y, Okumi M, Nakamura M, Tsuruya K, Nakano T, Tanabe K, Kitazono T; Japan Academic Consortium of Kidney Transplantation investigators

    Nephrol Dial Transplant   2021.1

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  • Nationwide temporal trend analysis of reperfusion therapy utilization and mortality in acute ischemic stroke patients in Japan. Reviewed International journal

    Maeda M, Fukuda H, Matsuo R, Kiyuna F, Ago T, Kitazono T, Kamouchi M

    Medicine (Baltimore)   2021.1

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  • N-Terminal Pro-B-Type Natriuretic Peptide and Incident CKD. Reviewed International journal

    Sasaki T, Oishi E, Nagata T, Sakata S, Chen S, Furuta Y, Honda T, Yoshida D, Hata J, Tsuboi N, Kitazono T, Yokoo T, Ninomiya T

    Kidney Int Rep   2021.1

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  • Measuring Quality of Care for Ischemic Stroke Treated With Acute Reperfusion Therapy in Japan - The Close The Gap-Stroke. Reviewed International journal

    Ren N, Nishimura A, Kurogi A, Nishimura K, Matsuo R, Ogasawara K, Hashimoto Y, Higashi T, Sakai N, Toyoda K, Shiokawa Y, Tominaga T, Miyachi S, Kada A, Abe K, Ono K, Matsumizu K, Arimura K, Kitazono T, Miyamoto S, Minematsu K, Iihara K

    Circ J   2021.1

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  • Association of hyperphosphatemia with an increased risk of sudden death in patients on hemodialysis: Ten-year outcomes of the Q-Cohort Study. Reviewed International journal

    Hiyamuta H, Yamada S, Taniguchi M, Tokumoto M, Tsuruya K, Nakano T, Kitazono T

    Atherosclerosis   2021.1

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  • Significance of revised criteria for chronic active T cell-mediated rejection in the 2017 Banff classification: Surveillance by 1-year protocol biopsies for kidney transplantation. Reviewed International journal

    Nakagawa K, Tsuchimoto A, Ueki K, Matsukuma Y, Okabe Y, Masutani K, Unagami K, Kakuta Y, Okumi M, Nakamura M, Nakano T, Tanabe K, Kitazono T; Japan Academic Consortium of Kidney Transplantation Investigators.

    Am J Transplant.   2021.1

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  • Serum N-terminal pro-B-type natriuretic peptide as a predictor for future development of atrial fibrillation in a general population: the Hisayama Study. Reviewed International journal

    Nagata T, Hata J, Sakata S, Oishi E, Honda T, Furuta Y, Ohara T, Yoshida D, Hirakawa Y, Shibata M, Ide T, Kitazono T, Tsutsui H, Ninomiya T.

    Int J Cardiol.   2020.12

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  • Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data. Reviewed International journal

    Thomalla G, Boutitie F, Ma H, Koga M, Ringleb P, Schwamm LH, Wu O, Bendszus M, Bladin CF, Campbell BCV, Cheng B, Churilov L, Ebinger M, Endres M, Fiebach JB, Fukuda-Doi M, Inoue M, Kleinig TJ, Latour LL, Lemmens R, Levi CR, Leys D, Miwa K, Molina CA, Muir KW, Nighoghossian N, Parsons MW, Pedraza S, Schellinger PD, Schwab S, Simonsen CZ, Song SS, Thijs V, Toni D, Hsu CY, Wahlgren N, Yamamoto H, Yassi N, Yoshimura S, Warach S, Hacke W, Toyoda K, Donnan GA, Davis SM, Gerloff C; Evaluation of unknown Onset Stroke thrombolysis trials (EOS) investigators. (Kitazono T)

    Lancet.   2020.11

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  • Anticoagulation and Risk of Stroke Recurrence in Patients with Embolic Stroke of Undetermined Source Having No Potential Source of Embolism. Reviewed International journal

    Sato N, Matsuo R, Kiyuna F, Nakamura K, Hata J, Wakisaka Y, Ago T, Kamouchi M, Kitazono T; collab on behalf of the Fukuoka Stroke Registry Investigators.

    Cerebrovasc Dis.   2020.11

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  • Comparison of Immunohistochemical Staining for Large T Antigen and Capsid Protein VP1 in BK Polyomavirus-Associated Nephropathy. Reviewed International journal

    Masutani K, Matsukuma Y, Tsuchimoto A, Okabe Y, Doi A, Kaku K, Nakamura M, Nakano T, Tsuruya K, Kitazono T.

    Nephron.   2020.11

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  • Prasugrel for Japanese Patients With Ischemic Heart Disease in Long-Term Clinical Practice (PRASFIT-Practice II) - Final 2-Year Follow-up Results of a Postmarketing Observational Study. Reviewed International journal

    Nakamura M, Kitazono T, Kozuma K, Sekine T, Nakamura S, Shiosakai K, Tanabe A, Iizuka T.

    Circ J.   2020.10

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  • Influence of the Accumulation of Unhealthy Eating Habits on Obesity in a General Japanese Population: The Hisayama Study. Reviewed International journal

    Ishida Y, Yoshida D, Honda T, Hirakawa Y, Shibata M, Sakata S, Furuta Y, Oishi E, Hata J, Kitazono T, Ninomiya T.

    Nutrients.   2020.10

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  • Association between serum glycated albumin and risk of cardiovascular disease in a Japanese community: The Hisayama Study. Reviewed International journal

    Mihara A, Ohara T, Hata J, Honda T, Chen S, Sakata S, Oishi E, Hirakawa Y, Nakao T, Kitazono T, Ninomiya T.

    Atherosclerosis.   2020.10

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  • Estimated plasma osmolarity and risk of end-stage kidney disease in patients with IgA nephropathy. Reviewed International journal

    Tanaka S, Nakano T, Tokumoto M, Masutani K, Tsuchimoto A, Ooboshi H, Kitazono T.

    Clin Exp Nephrol.   2020.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Additive effects of green tea and coffee on all-cause mortality in patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry. Reviewed International journal

    Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Yoshinari M, Oku Y, Higashi T, Nakamura U, Kitazono T.

    BMJ Open Diabetes Res Care.   2020.10

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  • Reciprocal Interaction Between Pericytes and Macrophage in Poststroke Tissue Repair and Functional Recovery. Reviewed International journal

    Shibahara T, Ago T, Tachibana M, Nakamura K, Yamanaka K, Kuroda J, Wakisaka Y, Kitazono T.

    Stroke.   2020.10

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  • Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation. Reviewed International journal

    Okumura K, Akao M, Yoshida T, Kawata M, Okazaki O, Akashi S, Eshima K, Tanizawa K, Fukuzawa M, Hayashi T, Akishita M, Lip GYH, Yamashita T; ELDERCARE-AF Committees and Investigators. (Kitazono T)

    N Engl J Med.   2020.10

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  • Arginase 2 is a mediator of ischemia-reperfusion injury in the kidney through regulation of nitrosative stress. Reviewed International journal

    Hara M, Torisu K, Tomita K, Kawai Y, Tsuruya K, Nakano T, Kitazono T.

    Kidney Int.   2020.9

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  • Incidence of severe hypoglycemia and its association with serum adiponectin in Japanese patients with type 1 and insulin-treated type 2 diabetes: The Fukuoka Diabetes Registry. Reviewed International journal

    Iwase M, Komorita Y, Fujii H, Ohkuma T, Ide H, Yoshinari M, Oku Y, Higashi T, Nakamura U, Kitazono T.

    J Diabetes Investig.   2020.9

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  • Adding Thiopurine After Loss of Response to Infliximab Versus Early Combination in Treating Crohn's Disease: A Retrospective Study. Reviewed International journal

    Zeze K, Hirano A, Torisu T, Esaki M, Moriyama T, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Kitazono T.

    Dig Dis Sci.   2020.9

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  • Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia-reperfusion injury. Reviewed International journal

    Okahara A, Koga JI, Matoba T, Fujiwara M, Tokutome M, Ikeda G, Nakano K, Tachibana M, Ago T, Kitazono T, Tsutsui H, Egashira K.

    Sci Rep.   2020.9

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  • Temporal trends and geographical disparities in comprehensive stroke centre capabilities in Japan from 2010 to 2018. Reviewed International journal

    Kurogi A, Nishimura A, Nishimura K, Kada A, Onozuka D, Hagihara A, Ogasawara K, Shiokawa Y, Kitazono T, Arimura K, Iihara K; J-ASPECT Study Collaborators.

    BMJ Open.   2020.8

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  • Higher Cholesterol Level Predicts Cardiovascular Event and Inversely Associates With Mortality in Hemodialysis Patients: 10-Year Outcomes of the Q-Cohort Study. Reviewed International journal

    Nakano T, Hiyamuta H, Yotsueda R, Tanaka S, Taniguchi M, Tsuruya K, Kitazono T.

    Ther Apher Dial.   2020.8

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  • Lifetime cumulative incidence of dementia in a community-dwelling elderly population in Japan. Reviewed International journal

    Yoshida D, Ohara T, Hata J, Shibata M, Hirakawa Y, Honda T, Furuta Y, Oishi E, Sakata S, Kanba S, Kitazono T, Ninomiya T.

    Neurology.   2020.8

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  • Impact of body mass index on real-world outcomes of rivaroxaban treatment in Japanese patients with non-valvular atrial fibrillation. Reviewed International journal

    Murakawa Y, Ikeda T, Ogawa S, Kitazono T, Nakagawara J, Minematsu K, Miyamoto S, Hayashi Y, Kidani Y, Okayama Y, Sunaya T, Sato S, Yamanaka S.

    Heart Vessels.   2020.8

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  • Small Dense Low-Density Lipoprotein Cholesterol and the Risk of Coronary Heart Disease in a Japanese Community. Reviewed International journal

    Higashioka M, Sakata S, Honda T, Hata J, Yoshida D, Hirakawa Y, Shibata M, Goto K, Kitazono T, Osawa H, Ninomiya T.

    J Atheroscler Thromb.   2020.7

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  • Clinical experience of treating Graves' hyperthyroidism complicated with malignancy-The possible role of potassium iodide for avoiding the risk of thionamide-associated neutropenia. Reviewed International journal

    Okamura K, Bandai S, Fujikawa M, Sato K, Kitazono T.

    Endocr J.   2020.7

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  • Association of serum phosphate concentration with the incidence of intervention for peripheral artery disease in patients undergoing hemodialysis: 10-year outcomes of the Q-Cohort Study. Reviewed International journal

    Shimamoto S, Yamada S, Hiyamuta H, Arase H, Taniguchi M, Tokumoto M, Nakano T, Tsuruya K, Kitazono T.

    Atherosclerosis.   2020.7

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  • 30-minute postload plasma glucose levels during an oral glucose tolerance test predict the risk of future type 2 diabetes: the Hisayama Study. Reviewed International journal

    Hirakawa Y, Hata J, Yoshinari M, Higashioka M, Yoshida D, Shibata M, Honda T, Sakata S, Kato H, Teramoto T, Maki H, Nishimoto S, Kitazono T, Ninomiya T.

    BMJ Open Diabetes Res Care.   2020.7

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  • Elevated serum glycated albumin and glycated albumin : hemoglobin A 1c ratio were associated with hippocampal atrophy in a general elderly population of Japanese: The Hisayama Study. Reviewed International journal

    Ohara T, Furuta Y, Hirabayashi N, Hata J, Hirakawa Y, Honda T, Yoshida D, Shibata M, Kitazono T, Ninomiya T.

    J Diabetes Investig.   2020.7

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  • Prevalence and Mortality of Sarcopenia in a Community-dwelling Older Japanese Population: The Hisayama Study. Reviewed International journal

    Nakamura K, Yoshida D, Honda T, Hata J, Shibata M, Hirakawa Y, Furuta Y, Kishimoto H, Ohara T, Kitazono T, Nakashima Y, Ninomiya T.

    J Epidemiol.   2020.6

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  • Association Between Plasma Intact Parathyroid Hormone Levels and the Prevalence of Atrial Fibrillation in Patients With Chronic Kidney Disease - The Fukuoka Kidney Disease Registry Study. Reviewed International journal

    Arase H, Yamada S, Tanaka S, Tokumoto M, Tsuruya K, Nakano T, Kitazono T.

    Circ J.   2020.6

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  • Utility of Columbia classification in focal segmental glomerulosclerosis: renal prognosis and treatment response among the pathological variants. Reviewed International journal

    Tsuchimoto A, Matsukuma Y, Ueki K, Tanaka S, Masutani K, Nakagawa K, Mitsuiki K, Uesugi N, Katafuchi R, Tsuruya K, Nakano T, Kitazono T.

    Nephrol Dial Transplant.   2020.6

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  • Serum uric acid levels and cardiovascular mortality in a general Japanese population: the Hisayama Study. Reviewed International journal

    Sakata S, Hata J, Honda T, Hirakawa Y, Oishi E, Shibata M, Yoshida D, Goto K, Kitazono T, Ninomiya T.

    Hypertens Res.   2020.6

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  • Thrombolysis With Alteplase at 0.6 mg/kg for Stroke With Unknown Time of Onset: A Randomized Controlled Trial. Invited Reviewed International journal

    Koga M, Yamamoto H, Inoue M, Asakura K, Aoki J, Hamasaki T, Kanzawa T, Kondo R, Ohtaki M, Itabashi R, Kamiyama K, Iwama T, Nakase T, Yakushiji Y, Igarashi S, Nagakane Y, Takizawa S, Okada Y, Doijiri R, Tsujino A, Ito Y, Ohnishi H, Inoue T, Takagi Y, Hasegawa Y, Shiokawa Y, Sakai N, Osaki M, Uesaka Y, Yoshimura S, Urabe T, Ueda T, Ihara M, Kitazono T, Sasaki M, Oita A, Yoshimura S, Fukuda-Doi M, Miwa K, Kimura K, Minematsu K, Toyoda K; THAWS Trial Investigators.

    Stroke.   2020.5

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  • Both hypo- and hyperglycaemia are associated with increased fracture risk in Japanese people with type 2 diabetes: the Fukuoka Diabetes Registry. Reviewed International journal

    Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Yoshinari M, Oku Y, Nakamura U, Kitazono T.

    Diabet Med.   2020.5

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  • Association of aortic valve calcification with carotid artery lesions and peripheral artery disease in patients with chronic kidney disease: a cross-sectional study. Reviewed International journal

    Arita Y, Nakayama M, Matsukuma Y, Yoshitomi R, Seki M, Fukui A, Tsuda S, Sonoda Y, Imazu R, Arakawa K, Tominaga M, Nakano T, Tsuruya K, Kitazono T.

    BMC Nephrol.   2020.5

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  • Association of Albuminuria With White Matter Hyperintensities Volume on Brain Magnetic Resonance Imaging in Elderly Japanese - The Hisayama Study. Reviewed International journal

    Yamasaki K, Hata J, Furuta Y, Hirabayashi N, Ohara T, Yoshida D, Hirakawa Y, Nakano T, Kitazono T, Ninomiya T.

    Circ J.   2020.5

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  • The Association between Dialysis Dose and Risk of Cancer Death in Patients Undergoing Hemodialysis: The Q-Cohort Study. Reviewed International journal

    Hara M, Tanaka S, Taniguchi M, Fujisaki K, Torisu K, Nakano T, Tsuruya K, Kitazono T.

    Intern Med.   2020.5

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  • The glucose degradation product methylglyoxal induces immature angiogenesis in patients undergoing peritoneal dialysis. Reviewed International journal

    Nakano T, Kumiko T, Mizumasa T, Kuroki Y, Tsuruya K, Kitazono T.

    Biochem Biophys Res Commun.   2020.5

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  • Effect of treatment modality and cerebral vasospasm agent on patient outcomes after aneurysmal subarachnoid hemorrhage in the elderly aged 75 years and older. Reviewed International journal

    Ido K, Kurogi R, Kurogi A, Nishimura K, Arimura K, Nishimura A, Ren N, Kada A, Matsuo R, Onozuka D, Hagihara A, Takagishi S, Yamagami K, Takegami M, Nohara Y, Nakashima N, Kamouchi M, Date I, Kitazono T, Iihara K; J-ASPECT Study Collaborators.

    PLos One.   2020.4

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  • Prevalence of bone fracture and its association with severe hypoglycemia in Japanese patients with type 1 diabetes. Invited Reviewed International journal

    Komorita Y, Minami M, Maeda Y, Yoshioka R, Ohkuma T, Kitazono T

    BMJ Open Diabetes Res Care   2020.4

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  • Effect of renin-angiotensin system blockade on graft survival and cardiovascular disease in kidney transplant recipients: retrospective multicenter study in Japan. Reviewed International journal

    Tsuchimoto A, Masutani K, Ueki K, Nakagawa K, Matsukuma Y, Tanaka S, Unagami K, Kakuta Y, Okumi M, Noguchi H, Kaku K, Okabe Y, Nakano T, Kitazono T, Nakamura M, Ishida H, Tanabe K; Japan Academic Consortium of Kidney Transplantation (JACK) Investigators.

    Clin Exp Nephrol.   2020.4

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  • The Incidence and Associated Factors of Sudden Death in Patients on Hemodialysis: 10-Year Outcome of the Q-Cohort Study. Reviewed International journal

    Hiyamuta H, Tanaka S, Taniguchi M, Tokumoto M, Fujisaki K, Nakano T, Tsuruya K, Kitazono T.

    J Atheroscler Thromb.   2020.4

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  • Association of Lower Serum Bilirubin With Loss of Residual Kidney Function in Peritoneal Dialysis Patients. Reviewed International journal

    Tsujikawa H, Tanaka S, Hara M, Kawai Y, Matsukuma Y, Torisu K, Nakano T, Tsuruya K, Kitazono T.

    Ther Apher Dial.   2020.4

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  • Increased Risk of Infection-Related and All-Cause Death in Hypercalcemic Patients Receiving Hemodialysis: The Q-Cohort Study. Reviewed International journal

    Yamada S, Arase H, Tokumoto M, Taniguchi M, Yoshida H, Nakano T, Tsuruya K, Kitazono T.

    Sci Rep.   2020.4

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  • Mucosal dysbiosis in patients with gastrointestinal follicular lymphoma. Reviewed International journal

    Zeze K, Hirano A, Torisu T, Esaki M, Shibata H, Moriyama T, Umeno J, Fujioka S, Okamoto Y, Fuyuno Y, Matsuno Y, Kitazono T.

    Hematol Oncol.   2020.4

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  • Clinical Risk Factors of Thromboembolic and Major Bleeding Events for Patients with Atrial Fibrillation Treated with Rivaroxaban in Japan. Reviewed International journal

    Miyamoto S, Ikeda T, Ogawa S, Kitazono T, Nakagawara J, Minematsu K, Murakawa Y, Iwashiro S, Takeichi M, Kidani Y, Okayama Y, Sunaya T, Sato S, Yamanaka S.

    J Stroke Cerebrovasc Dis.   2020.4

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  • Safety and Efficacy of Prasugrel in Elderly/Low Body Weight Japanese Patients with Ischemic Stroke: Randomized PRASTRO-II. Reviewed International journal

    Kitagawa K, Toyoda K, Kitazono T, Nishikawa M, Nanto S, Ikeda Y, Abe K, Ogawa A.

    Cerebrovasc Dis.   2020.3

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  • Ratios of serum eicosapentaenoic acid to arachidonic acid and docosahexaenoic acid to arachidonic acid were inversely associated with serum resistin levels: The Hisayama Study. Reviewed International journal

    Higashioka M, Hirakawa Y, Kawamura R, Honda T, Hata J, Yoshida D, Takata Y, Kitazono T, Osawa H, Ninomiya T.

    J Diabetes Investig.   2020.3

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  • Real-world outcomes of rivaroxaban treatment in elderly Japanese patients with nonvalvular atrial fibrillation. Reviewed International journal

    Kitazono T, Ikeda T, Ogawa S, Nakagawara J, Minematsu K, Miyamoto S, Murakawa Y, Cavaliere M, Hayashi Y, Kidani Y, Okayama Y, Sunaya T, Sato S, Yamanaka S.

    Heart Vessels.   2020.3

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  • Short-term and long-term outcomes of indigo naturalis treatment for inflammatory bowel disease. Reviewed International journal

    Matsuno Y, Hirano A, Torisu T, Okamoto Y, Fuyuno Y, Fujioka S, Umeno J, Moriyama T, Nagai S, Hori Y, Fujiwara M, Kitazono T, Esaki M.

    J Gastroenterol Hepatol.   2020.3

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  • Smoking Status and Functional Outcomes After Acute Ischemic Stroke. Reviewed International journal

    Matsuo R, Ago T, Kiyuna F, Sato N, Nakamura K, Kuroda J, Wakisaka Y, Kitazono T; Fukuoka Stroke Registry Investigators.

    Stroke.   2020.3

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  • Pericyte-Mediated Tissue Repair through PDGFRβ Promotes Peri-Infarct Astrogliosis, Oligodendrogenesis, and Functional Recovery after Acute Ischemic Stroke. Reviewed International journal

    2020.3

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  • Early Initiation of Direct Oral Anticoagulants After Onset of Stroke and Short- and Long-Term Outcomes of Patients With Nonvalvular Atrial Fibrillation. Reviewed International journal

    Mizoguchi T, Tanaka K, Toyoda K, Yoshimura S, Itabashi R, Takagi M, Todo K, Shiozawa M, Yagita Y, Yoshimoto T, Terasaki T, Yamagami H, Takizawa S, Inoue M, Kamiyama K, Ihara M, Okada Y, Kitazono T, Koga M; SAMURAI Study Investigators.

    Stroke.   2020.3

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  • Colorectal diffuse large B-cell lymphoma: molecular subclassification and prognostic significance of immunoglobulin gene translocation. Reviewed International journal

    Hori Y, Yamamoto H, Nozaki Y, Torisu T, Fujiwara M, Taguchi K, Nishiyama K, Nakamura S, Kitazono T, Oda Y.

    Hum Pathol.   2020.2

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  • Lower Serum Albumin Level Is Associated With an Increased Risk for Loss of Residual Kidney Function in Patients Receiving Peritoneal Dialysis. Reviewed International journal

    Yamada S, Kawai Y, Tsuneyoshi S, Tsujikawa H, Arase H, Yoshida H, Tsuruya K, Nakano T, Kitazono T.

    Ther Apher Dial.   2020.2

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  • Lidocaine-Propitocain Cream, a Eutectic Mixture of Local Anesthetics, Effectively Relieves Pain Associated With Vascular Access Intervention Therapy in Patients Undergoing Hemodialysis: A Placebo-Controlled, Double-Blind, Crossover Study. Reviewed International journal

    Aihara S, Yamada S, Shichijo S, Fukumitsu K, Kondo M, Hirashima Y, Oka H, Kamimura T, Harada A, Nakano T, Tsuruya K, Kitazono T.

    Ther Apher Dial.   2020.2

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  • Predictive Factors for Rebleeding after Negative Capsule Endoscopy among Patients with Overt Obscure Gastrointestinal Bleeding. Reviewed International journal

    Harada A, Torisu T, Okamoto Y, Hirano A, Umeno J, Moriyama T, Washio E, Fuyuno Y, Fujioka S, Kitazono T, Esaki M.

    Digestion.   2020.1

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  • Impact of hip fracture on all-cause mortality in Japanese patients with type 2 diabetes mellitus: The Fukuoka Diabetes Registry. Reviewed International journal

    Komorita Y, Iwase M, Idewaki Y, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Yoshinari M, Murao-Kimura A, Oku Y, Nakamura U, Kitazono T.

    J Diabetes Investig.   2020.1

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  • Modified creatinine index and risk for long-term infection-related mortality in hemodialysis patients: ten-year outcomes of the Q-Cohort Study. Reviewed International journal

    Arase H, Yamada S, Hiyamuta H, Taniguchi M, Tokumoto M, Tsuruya K, Nakano T, Kitazono T.

    Sci Rep.   2020.1

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  • Advanced glycation end products are associated with immature angiogenesis and peritoneal dysfunction in patients on peritoneal dialysis. Reviewed International journal

    Nakano T, Mizumasa T, Kuroki Y, Eriguchi M, Yoshida H, Taniguchi M, Masutani K, Tsuruya K, Kitazono T.

    Perit Dial Int.   2020.1

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  • Real-world Outcomes of Rivaroxaban Treatment in Patients With Nonvalvular Atrial Fibrillation and Worsening Renal Function Reviewed International journal

    Nakagawara J, Ikeda T, Ogawa S, Kitazono T, Minematsu K, Miyamoto S, Murakawa Y, Takeichi M, Kidani Y, Okayama Y, Sunaya T, Sato S, Yamanaka S.

    J Cardiol.   2019.12

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  • Prasugrel for Japanese Patients With Ischemic Heart Disease in Long-Term Clinical Practice (PRASFIT-Practice II) - 1-Year Follow-up Results of a Postmarketing Observational Study Reviewed International journal

    Nakamura M, Kitazono T, Kozuma K, Sekine T, Nakamura S, Shiosakai K, Iizuka T.

    Circ J.   2019.12

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  • Serum Elaidic Acid Concentration and Risk of Dementia: The Hisayama Study Reviewed International journal

    Honda T, Ohara T, Shinohara M, Hata J, Toh R, Yoshida D, Shibata M, Ishida T, Hirakawa Y, Irino Y, Sakata S, Uchida K, Kitazono T, Kanba S, Hirata KI, Ninomiya T.

    Neurology.   2019.11

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  • Serum Lipopolysaccharide-Binding Protein Levels and the Incidence of Cardiovascular Disease in a General Japanese Population: The Hisayama Study Reviewed International journal

    Asada M, Oishi E, Sakata S, Hata J, Yoshida D, Honda T, Furuta Y, Shibata M, Suzuki K, Watanabe H, Murayama N, Kitazono T, Yamaura K, Ninomiya T.

    J Am Heart Assoc.   2019.11

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  • Development and Validation of a New Prediction Model for Graft Function Using Preoperative Marginal Factors in Living-Donor Kidney Transplantation Reviewed International journal

    Matsukuma Y, Masutani K, Tanaka S, Tsuchimoto A, Nakano T, Okabe Y, Kakuta Y, Okumi M, Tsuruya K, Nakamura M, Kitazono T, Tanabe K; Japan Academic Consortium of Kidney Transplantation (JACK) Investigators.

    Clin Exp Nephrol.   2019.11

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  • Higher Cholesterol Level Predicts Cardiovascular Event and Inversely Associates With Mortality in Hemodialysis Patients: 10-Year Outcomes of the Q-Cohort Study Reviewed International journal

    Nakano T, Hiyamuta H, Yotsueda R, Tanaka S, Taniguchi M, Tsuruya K, Kitazono T.

    Ther Apher Dial.   2019.11

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  • Global Outcome Assessment Life-long After Stroke in Young Adults Initiative-The GOAL Initiative: Study Protocol and Rationale of a Multicentre Retrospective Individual Patient Data Meta-Analysis Reviewed International journal

    BMJ Open.   2019.11

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  • Clinical Risk Factors of Stroke and Major Bleeding in Patients With Non-Valvular Atrial Fibrillation Under Rivaroxaban: The EXPAND Study Sub-Analysis Reviewed International journal

    Sakuma I, Uchiyama S, Atarashi H, Inoue H, Kitazono T, Yamashita T, Shimizu W, Ikeda T, Kamouchi M, Kaikita K, Fukuda K, Origasa H, Shimokawa H.

    Heart Vessels.   2019.11

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  • Small Dense Low-Density Lipoprotein Cholesterol and the Risk of Coronary Heart Disease in a Japanese Community Reviewed International journal

    Higashioka M, Sakata S, Honda T, Hata J, Yoshida D, Hirakawa Y, Shibata M, Goto K, Kitazono T, Osawa H, Ninomiya T.

    J Atheroscler Thromb.   2019.11

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  • Outcomes Associated With Under-Dosing of Rivaroxaban for Management of Non-Valvular Atrial Fibrillation in Real-World Japanese Clinical Settings Reviewed International journal

    Ikeda T, Ogawa S, Kitazono T, Nakagawara J, Minematsu K, Miyamoto S, Murakawa Y, Iwashiro S, Kidani Y, Okayama Y, Sunaya T, Sato S, Yamanaka S.

    J Thromb Thrombolysis.   2019.11

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  • High neutrophil/lymphocyte Ratio Is Associated With Poor Renal Outcomes in Japanese Patients With Chronic Kidney Disease Reviewed International journal

    Yoshitomi R, Nakayama M, Sakoh T, Fukui A, Katafuchi E, Seki M, Tsuda S, Nakano T, Tsuruya K, Kitazono T.

    Ren Fail.   2019.11

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  • Development of Quality Indicators of Stroke Centers and Feasibility of Their Measurement Using a Nationwide Insurance Claims Database in Japan ― J-ASPECT Study ― Reviewed International journal

    2019.10

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  • Hemodialysis Treatment Time Versus Erythropoietin Dose Requirement: Reduction in 2,000 Units Per Week by Extension of Hemodialysis for 1 Hour Reviewed International journal

    Maeda A, Tsuruya K, Maeda M, Yamasaki M, Nakashima A, Nakashima Y, Date S, Maeda T, Kamijyou M, Kubara T, Hayashi W, Kitazono T.

    Clin Nephrol.   2019.10

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  • Upregulation of Annexin A1 in Reactive Astrocytes and Its Subtle Induction in Microglia at the Boundaries of Human Brain Infarcts Reviewed International journal

    Shijo M, Hamasaki H, Honda H, Suzuki SO, Tachibana M, Ago T, Kitazono T, Iihara K, Iwaki T.

    J Neuropathol Exp Neurol.   2019.10

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  • Factors Associated With Postprocedural Diffusion-Weighted Imaging-Positive Lesions in Endovascular Treatment for Unruptured Cerebral Aneurysms Reviewed International journal

    Tokunaga K, Hatano T, Nakahara I, Ishii A, Higashi E, Kamata T, Funakoshi Y, Hashikawa T, Takita W, Chihara H, Ando M, Sadamasa N, Kitazono T, Nagata I.

    World Neurosurg.   2019.10

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  • Real-World Outcomes of Rivaroxaban Treatment in Patients With Both Nonvalvular Atrial Fibrillation and a History of Ischemic Stroke/Transient Ischemic Attack Reviewed International journal

    Minematsu K, Ikeda T, Ogawa S, Kitazono T, Nakagawara J, Miyamoto S, Murakawa Y, Takeichi M, Kidani Y, Okayama Y, Sunaya T, Sato S, Yamanaka S.

    Cerebrovasc Dis.   2019.10

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  • National Trends in Outcomes of Ischemic Stroke and Prognostic Influence of Stroke Center Capability in Japan, 2010-2016 Reviewed International journal

    Kada A, Ogasawara K, Kitazono T, Nishimura K, Sakai N, Onozuka D, Shiokawa Y, Miyachi S, Nagata I, Toyoda K, Hashimoto Y, Hasegawa Y, Hoshino H, Yoshimura S, Suzuki M, Tsujino A, Matsuda S, Kurogi R, Kurogi A, Ren N, Nishimura A, Arimura K, Hagihara A, Tominaga T, Kayama T, Arai H, Suzuki N, Miyamoto S, Ogawa A, Iihara K; J-ASPECT Study Collaborators.

    Int J Stroke.   2019.10

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  • Risk Factors for Reflux Esophagitis After Eradication of Helicobacter pylori Reviewed International journal

    Harada A, Kurahara K, Moriyama T, Tanaka T, Nagata Y, Kawasaki K, Yaita H, Maehata Y, Umeno J, Oshiro Y, Fuchigami T, Kitazono T, Esaki M, Matsumoto T.

    Scand J Gastroenterol.   2019.10

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  • NT-proBNP and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study Reviewed International journal

    Nagata T, Ohara T, Hata J, Sakata S, Furuta Y, Yoshida D, Honda T, Hirakawa Y, Ide T, Kanba S, Kitazono T, Tsutsui H, Ninomiya T.

    J Am Heart Assoc.   2019.9

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  • Relative Hypophosphatemia Early After Transplantation Is a Predictor of Good Kidney Graft Function Invited Reviewed International journal

    Nakai K, Mitsuiki K, Kuroki Y, Nishiki T, Motoyama K, Nakano T, Kitazono T.

    Clin Exp Nephrol.   2019.9

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  • Usefulness of Transesophageal Echocardiography for Predicting Covert Paroxysmal Atrial Fibrillation in Patients With Embolic Stroke of Undetermined Source Reviewed International journal

    Ohya Y, Osaki M, Fujimoto S, Jinnouchi J, Matsuki T, Mezuki S, Kumamoto M, Kanazawa M, Tagawa N, Ago T, Kitazono T, Arakawa S.

    Cerebrovasc Dis Extra.   2019.9

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  • Early Initiation of a Factor Xa Inhibitor Can Attenuate Tissue Repair and Neurorestoration After Middle Cerebral Artery Occlusion Reviewed International journal

    Komori M, Ago T, Wakisaka Y, Nakamura K, Tachibana M, Yoshikawa Y, Shibahara T, Yamanaka K, Kuroda J, Kitazono T.

    Brain Res.   2019.9

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  • Reduced Estimated GFR and Cardiac Remodeling: A Population-Based Autopsy Study Reviewed International journal

    Izumaru K, Hata J, Nakano T, Nakashima Y, Nagata M, Fukuhara M, Oda Y, Kitazono T, Ninomiya T.

    Am J Kidney Dis.   2019.9

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  • Association Between Serum β-Alanine and Risk of Dementia Reviewed International journal

    2019.9

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  • Real-world Outcomes of the Xarelto Post-Authorization Safety & Effectiveness Study in Japanese Patients With Atrial Fibrillation (XAPASS) Reviewed International journal

    Ikeda T, Ogawa S, Kitazono T, Nakagawara J, Minematsu K, Miyamoto S, Murakawa Y, Takeichi M, Ohashi Y, Okayama Y, Sunaya T, Yamanaka S.

    J Cardiol.   2019.7

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  • Risk of Surgery in Patients With Stricturing Type of Crohn's Disease at the Initial Diagnosis: A Single Center Experience Reviewed International journal

    Maehata Y, Nagata Y, Moriyama T, Matsuno Y, Hirano A, Umeno J, Torisu T, Manabe T, Kitazono T, Esaki M.

    Intest Res.   2019.7

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  • Endoscopic Features of Gastrointestinal Stromal Tumor in the Small Intestine Reviewed International journal

    Ihara Y, Torisu T, Moriyama T, Umeno J, Hirano A, Okamoto Y, Hori Y, Yamamoto H, Kitazono T, Esaki M.

    Intest Res.   2019.7

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  • The Long-Term Follow-Up of Patients With Thionamide-Treated Graves' Hyperthyroidism Invited Reviewed International journal

    Bandai S, Okamura K, Fujikawa M, Sato K, Ikenoue H, Kitazono T.

    Endocr J.   2019.6

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  • Predictive Value of the Combination of Peripheral Blood Lymphocyte Count and Urinary Cytology in BK Polyomavirus-associated Nephropathy Reviewed International journal

    Masutani K, Tsuchimoto A, Matsukuma Y, Tanaka S, Kaku K, Noguchi H, Kurihara K, Okabe Y, Nakano T, Tsuruya K, Nakashima H, Nakamura M, Kitazono T.

    Transplant Proc.   2019.6

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  • Arterial Spin Labeling Magnetic Resonance Imaging for Differentiating Acute Ischemic Stroke From Epileptic Disorders Reviewed International journal

    Kanazawa Y, Arakawa S, Shimogawa T, Hagiwara N, Haga S, Morioka T, Ooboshi H, Ago T, Kitazono T.

    J Stroke Cerebrovasc Dis.   2019.6

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  • Dairy Consumption and Risk of Functional Disability in an Elderly Japanese Population: The Hisayama Study Reviewed International journal

    Yoshida D, Ohara T, Hata J, Shibata M, Hirakawa Y, Honda T, Uchida K, Takasugi S, Kitazono T, Kiyohara Y, Ninomiya T.

    Am J Clin Nutr.   2019.6

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  • Angiotensin-converting Enzyme Inhibitors Versus Angiotensin Receptor Blockers in Hypertensive Patients With Myocardial Infarction or Heart Failure: A Systematic Review and Meta-Analysis Reviewed International journal

    Ohtsubo T, Shibata R, Kai H, Okamoto R, Kumagai E, Kawano H, Fujiwara A, Kitazono T, Murohara T, Arima H.

    Hypertens Res.   2019.5

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  • Poor Glycemic Control and Posterior Circulation Ischemic Stroke Reviewed International journal

    Kuroda J, Matsuo R, Yamaguchi Y, Sato N, Kamouchi M, Hata J, Wakisaka Y, Ago T, Kitazono T; Fukuoka Stroke Registry Investigators.

    Neurol Clin Pract.   2019.4

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  • Blood Urea Nitrogen Is Independently Associated With Renal Outcomes in Japanese Patients With Stage 3-5 Chronic Kidney Disease: A Prospective Observational Study Reviewed International journal

    Seki M, Nakayama M, Sakoh T, Yoshitomi R, Fukui A, Katafuchi E, Tsuda S, Nakano T, Tsuruya K, Kitazono T.

    BMC Nephrol.   2019.4

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  • Anti-tumor Necrosis Factor Therapy Decreases the Risk of Initial Intestinal Surgery After Diagnosis of Crohn's Disease of Inflammatory Type Reviewed International journal

    Nagata Y, Esaki M, Moriyama T, Hirano A, Umeno J, Maehata Y, Torisu T, Matsumoto T, Kitazono T.

    J Gastroenterol.   2019.4

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  • Better Oral Hygiene Habits Are Associated With a Lower Incidence of Peritoneal Dialysis-Related Peritonitis Reviewed International journal

    Oka H, Yamada S, Kamimura T, Aihara S, Hyodo M, Terakado N, Harada A, Nakano T, Tsuruya K, Kitazono T.

    Ther Apher Dial.   2019.4

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  • Kidney Transplantation for Treatment of End-Stage Kidney Disease After Haematopoietic Stem Cell Transplantation: Case Series and Literature Review Reviewed International journal

    Tsuchimoto A, Masutani K, Omoto K, Okumi M, Okabe Y, Nishiki T, Ota M, Nakano T, Tsuruya K, Kitazono T, Nakamura M, Ishida H, Tanabe K; Japan Academic Consortium of Kidney Transplantation (JACK) Investigators.

    Clin Exp Nephrol.   2019.4

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  • Measurement of Prostaglandin Metabolites Is Useful in Diagnosis of Small Bowel Ulcerations Reviewed International journal

    Matsuno Y, Umeno J, Esaki M, Hirakawa Y, Fuyuno Y, Okamoto Y, Hirano A, Yasukawa S, Hirai F, Matsui T, Hosomi S, Watanabe K, Hosoe N, Ogata H, Hisamatsu T, Yanai S, Kochi S, Kurahara K, Yao T, Torisu T, Kitazono T, Matsumoto T.

    World J Gastroenterol.   2019.4

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  • C-reactive Protein and Incident Hypertension in a Worksite Population of Japanese Men Reviewed International journal

    Kansui Y, Matsumura K, Morinaga Y, Inoue M, Kiyohara K, Ohta Y, Goto K, Ohtsubo T, Ooboshi H, Kitazono T.

    J Clin Hypertens (Greenwich).   2019.4

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  • Rapidly Progressive Glomerulonephritis With Delayed Appearance of Anti-Glomerular Basement Membrane Antibody Successfully Treated With Multiple Courses of Steroid Pulse Therapy Reviewed International journal

    Toyota S, Eriguchi M, Hasegawa S, Ueki K, Matsukuma Y, Tsuchimoto A, Fujisaki K, Torisu K, Tsuruya K, Nakano T, Kitazono T.

    Case Rep Nephrol Dial.   2019.4

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  • Achieving LDL Cholesterol Target Levels <1.81 mmol/L May Provide Extra Cardiovascular Protection in Patients at High Risk: Exploratory Analysis of the Standard Versus Intensive Statin Therapy for Patients With Hypercholesterolaemia and Diabetic Retinopathy Study Reviewed International journal

    Itoh H, Komuro I, Takeuchi M, Akasaka T, Daida H, Egashira Y, Fujita H, Higaki J, Hirata KI, Ishibashi S, Isshiki T, Ito S, Kashiwagi A, Kato S, Kitagawa K, Kitakaze M, Kitazono T, Kurabayashi M, Miyauchi K, Murakami T, Murohara T, Node K, Ogawa S, Saito Y, Seino Y, Shigeeda T, Shindo S, Sugawara M, Sugiyama S, Terauchi Y, Tsutsui H, Ueshima K, Utsunomiya K, Yamagishi M, Yamazaki T, Yo S, Yokote K, Yoshida K, Yoshimura M, Yoshimura N, Nakao K, Nagai R; EMPATHY Investigators.

    Diabetes Obes Metab.   2019.4

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  • Trends in the Prevalence of Airflow Limitation in a General Japanese Population: Two Serial Cross-Sectional Surveys From the Hisayama Study Reviewed International journal

    Ogata H, Hirakawa Y, Matsumoto K, Hata J, Yoshida D, Fukuyama S, Inoue H, Kitazono T, Ninomiya T, Nakanishi Y.

    BMJ Open.   2019.3

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  • Early Postoperative Change in Serum Creatinine Predicts Acute Kidney Injury After Cardiothoracic Surgery: A Retrospective Cohort Study Reviewed International journal

    Oka H, Yamada S, Kamimura T, Harada A, Tsuruya K, Nakano T, Kitazono T.

    Clin Exp Nephrol.   2019.3

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  • Association of B-Type Natriuretic Peptide Level With Residual Kidney Function in Incident Peritoneal Dialysis Patients Reviewed International journal

    Kawai Y, Tanaka S, Yoshida H, Hara M, Tsujikawa H, Tsuruya K, Kitazono T.

    Perit Dial Int.   2019.3

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  • Development of a Risk Prediction Model for Infection-Related Mortality in Patients Undergoing Peritoneal Dialysis Reviewed International journal

    Tsujikawa H, Tanaka S, Matsukuma Y, Kanai H, Torisu K, Nakano T, Tsuruya K, Kitazono T.

    PLoS One.   2019.3

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  • Capsule Endoscopy Findings for the Diagnosis of Crohn's Disease: A Nationwide Case-Control Study Reviewed International journal

    Esaki M, Matsumoto T, Ohmiya N, Washio E, Morishita T, Sakamoto K, Abe H, Yamamoto S, Kinjo T, Togashi K, Watanabe K, Hirai F, Nakamura M, Nouda S, Ashizuka S, Omori T, Kochi S, Yanai S, Fuyuno Y, Hirano A, Umeno J, Kitazono T, Kinjo F, Watanabe M, Matsui T, Suzuki Y.

    J Gastroenterol.   2019.3

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  • Serum Magnesium and Calcium Levels in Relation to Ischemic Stroke: Mendelian Randomization Study Reviewed International journal

    Neurology.   2019.2

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  • Prasugrel for Japanese Patients With Ischemic Heart Disease in Long-Term Clinical Practice (PRASFIT-Practice II) - A 3-Month Interim Analysis of a Postmarketing Observational Study Reviewed International journal

    Nakamura M, Kozuma K, Kitazono T, Iizuka T, Sekine T, Shiosakai K, Usui I, Kogure S.

    Circ J.   2019.2

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  • Association of Geriatric Nutritional Risk Index With Infection-Related Mortality in Patients Undergoing Hemodialysis: The Q-Cohort Study Reviewed International journal

    Matsukuma Y, Tanaka S, Taniguchi M, Nakano T, Masutani K, Hirakata H, Kitazono T, Tsuruya K.

    Clin Nutr.   2019.2

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  • Colorectal Endoscopic Submucosal Dissection Using Novel Articulating Devices: A Comparative Study in a Live Porcine Model Reviewed International journal

    Okamoto Y, Nakadate R, Nakamura S, Arata J, Oguri S, Moriyama T, Esaki M, Iwasa T, Ohuchida K, Akahoshi T, Ikeda T, Kitazono T, Hashizume M.

    Surg Endosc.   2019.2

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  • Prospective Study of Cancer in Japanese Patients With Type 2 Diabetes: The Fukuoka Diabetes Registry Reviewed International journal

    Iwase M, Fujii H, Idewaki Y, Nakamura U, Ohkuma T, Ide H, Komorita Y, Jodai-Kitamura T, Yoshinari M, Kitazono T.

    Diabetol Int.   2019.2

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  • Primary and Secondary Prevention of Stroke and Systemic Embolism With Rivaroxaban in Patients With Non-Valvular Atrial Fibrillation : Sub-analysis of the EXPAND Study Reviewed International journal

    Uchiyama S, Atarashi H, Inoue H, Kitazono T, Yamashita T, Shimizu W, Ikeda T, Kamouchi M, Kaikita K, Fukuda K, Origasa H, Shimokawa H.

    Heart Vessels.   2019.1

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  • Primary and Secondary Prevention of Stroke and Systemic Embolism With Rivaroxaban in Patients With Non-Valvular Atrial Fibrillation : Sub-analysis of the EXPAND Study Reviewed International journal

    Uchiyama S, Atarashi H, Inoue H, Kitazono T, Yamashita T, Shimizu W, Ikeda T, Kamouchi M, Kaikita K, Fukuda K, Origasa H, Shimokawa H.

    Heart Vessels.   2019.1

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  • Apparent Treatment-Resistant Hypertension and Cardiovascular Risk in Hemodialysis Patients: Ten-Year Outcomes of the Q-Cohort Study Reviewed International journal

    Tanaka S, Ninomiya T, Hiyamuta H, Taniguchi M, Tokumoto M, Masutani K, Ooboshi H, Nakano T, Tsuruya K, Kitazono T.

    Sci Rep.   2019.1

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  • Serum Soluble Triggering Receptor Expressed on Myeloid Cells 2 as a Biomarker for Incident Dementia: The Hisayama Study Reviewed International journal

    Ohara T, Hata J, Tanaka M, Honda T, Yamakage H, Yoshida D, Inoue T, Hirakawa Y, Kusakabe T, Shibata M, Teraoka T, Kitazono T, Kanba S, Satoh-Asahara N, Ninomiya T.

    Ann Neurol.   2019.1

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  • Utility of Columbia Classification in Focal Segmental Glomerulosclerosis: Renal Prognosis and Treatment Response Among the Pathological Variants Reviewed International journal

    Tsuchimoto A, Matsukuma Y, Ueki K, Tanaka S, Masutani K, Nakagawa K, Mitsuiki K, Uesugi N, Katafuchi R, Tsuruya K, Nakano T, Kitazono T.

    Nephrol Dial Transplant.   2019.1

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  • Prevalence of Adult Epilepsy in a General Japanese Population: The Hisayama Study Reviewed International journal

    Tanaka A, Hata J, Akamatsu N, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Ohara T, Mizuno T, Tsuji S, Kitazono T, Ninomiya T.

    Epilepsia Open.   2019.1

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  • Prognostic value of pre-dialysis blood pressure and risk threshold on clinical outcomes in hemodialysis patients: The Q-Cohort Study. Reviewed International journal

    Hara M, Tanaka S, Taniguchi M, Fujisaki K, Torisu K, Masutani K, Hirakata H, Nakano T, Tsuruya K, Kitazono T.

    Medicine (Baltimore).   2018.12

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  • The serum creatinine to cystatin C ratio predicts bone fracture in patients with type 2 diabetes: The Fukuoka Diabetes Registry. Reviewed International journal

    Komorita Y, Iwase M, Fujii H, Ide H, Ohkuma T, Jodai-Kitamura T, Sumi A, Yoshinari M, Nakamura U, Kitazono T.

    Diabetes Res Clin Pract.   2018.12

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  • Development and validation of modified risk prediction models for cardiovascular disease and its subtypes: The Hisayama Study. Reviewed International journal

    Honda T, Yoshida D, Hata J, Hirakawa Y, Ishida Y, Shibata M, Sakata S, Kitazono T, Ninomiya T.

    Atherosclerosis.   2018.12

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  • Impact of obstructive sleep apnea on long-term blood pressure variability in Japanese men: a cross-sectional study of a work-site population. Reviewed International journal

    Kansui Y, Matsumura K, Morinaga Y, Inoue M, Sakata S, Oishi E, Goto K, Ohtsubo T, Ooboshi H, Kitazono T.

    Hypertens Res.   2018.11

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  • A case of congenital left ventricular diverticulum in a patient with autosomal dominant polycystic kidney disease: possible mechanistic link between polycystin and ventricular diverticulum. Reviewed International journal

    Aihara S, Yamada S, Matsusaka H, Tashiro R, Oka H, Kamimura T, Harada A, Nakano T, Kitazono T, Tsuruya K.

    CEN Case Rep.   2018.11

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  • Subacute Methotrexate Encephalopathy Mimicking Ischemic Stroke With Dynamic Changes on Magnetic Resonance Imaging. Reviewed International journal

    Yamanaka K, Okata T, Sambongi Y, Yamanaka I, Tanimoto K, Ago T, Kitazono T, Kitayama J.

    J Stroke Cerebrovasc Dis.   2018.11

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  • Influence of cytochrome P450 polymorphisms on the antiplatelet effects of prasugrel in patients with non-cardioembolic stroke previously treated with clopidogrel. Reviewed International journal

    Kitazono T, Ikeda Y, Nishikawa M, Yoshiba S, Abe K, Ogawa A.

    J Thromb Thrombolysis.   2018.11

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  • Safety of antithrombotic therapy for patients with acute ischemic stroke harboring unruptured intracranial aneurysm. Reviewed International journal

    Shono Y, Sugimori H, Matsuo R, Fukushima Y, Wakisaka Y, Kuroda J, Ago T, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators

    Int J Stroke   2018.10

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  • Association Between Daily Sleep Duration and Risk of Dementia and Mortality in a Japanese Community. Reviewed International journal

    Ohara T, Honda T, Hata J, Yoshida D, Mukai N, Hirakawa Y, Shibata M, Kishimoto H, Kitazono T, Kanba S, Ninomiya T.

    J Am Geriatr Soc.   2018.10

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  • Anti-Xa Activity and Event Risk in Patients With Direct Factor Xa Inhibitors Initiated Early After Stroke. Reviewed International journal

    Wada S, Toyoda K, Sato S, Matsuki T, Okata T, Kumamoto M, Tagawa N, Inoue M, Okamoto A, Ihara M, Kitazono T, Miyata T, Koga M.

    Circ J.   2018.10

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  • Immobilization-induced severe hypercalcaemia successfully treated with reduced dose of zoledronate in a maintenance haemodialysis patient. Reviewed International journal

    Yamada S, Arase H, Tachibana S, Tomita K, Eriguchi M, Fujisaki K, Okabe Y, Nakamura M, Nakano T, Tsuruya K, Kitazono T.

    Nephrology (Carlton).   2018.10

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  • Association of Embolic Sources With Cause-Specific Functional Outcomes Among Adults With Cryptogenic Stroke. Reviewed International journal

    Kiyuna F, Sato N, Matsuo R, Kamouchi M, Hata J, Wakisaka Y, Kuroda J, Ago T, Kitazono T; Fukuoka Stroke Registry Investigators.

    JAMA Netw Open.   2018.9

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  • Impact of age at menarche on obesity and glycemic control in Japanese patients with type 2 diabetes: Fukuoka Diabetes Registry. Reviewed International journal

    Sumi A, Iwase M, Nakamura U, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Komorita Y, Yoshinari M, Kitazono T.

    J Diabetes Investig.   2018.9

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  • Association between the ratio of serum arachidonic acid to eicosapentaenoic acid and the presence of depressive symptoms in a general Japanese population: the Hisayama Study. Reviewed International journal

    Shibata M, Ohara T, Yoshida D, Hata J, Mukai N, Kawano H, Kanba S, Kitazono T, Ninomiya T.

    J Affect Disord.   2018.9

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  • Association between stroke-like episodes and neuronal hyperexcitability in MELAS with m.3243A>G: A case report. Reviewed International journal

    Sakai S, Osaki M, Hidaka M, Kimura S, Ohya Y, Ago T, Kitazono T, Arakawa S.

    eNeurologicalSci.   2018.8

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  • Clinical features of chronic enteropathy associated with SLCO2A1 gene: a new entity clinically distinct from Crohn's disease. Reviewed International journal

    Umeno J, Esaki M, Hirano A, Fuyuno Y, Ohmiya N, Yasukawa S, Hirai F, Kochi S, Kurahara K, Yanai S, Uchida K, Hosomi S, Watanabe K, Hosoe N, Ogata H, Hisamatsu T, Nagayama M, Yamamoto H, Abukawa D, Kakuta F, Onodera K, Matsui T, Hibi T, Yao T, Kitazono T, Matsumoto T; CEAS study group.

    J Gastroenterol.   2018.8

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  • Modified creatinine index and risk for cardiovascular events and all-cause mortality in patients undergoing hemodialysis: The Q-Cohort study. Reviewed International journal

    Arase H, Yamada S, Yotsueda R, Taniguchi M, Yoshida H, Tokumoto M, Nakano T, Tsuruya K, Kitazono T.

    Atherosclerosis.   2018.8

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  • Overexpression of MTH1 and OGG1 proteins in ulcerative colitis-associated carcinogenesis. Reviewed International journal

    Kumagae Y, Hirahashi M, Takizawa K, Yamamoto H, Gushima M, Esaki M, Matsumoto T, Nakamura M, Kitazono T, Oda Y.

    Oncol Lett.   2018.8

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  • Use of phosphate-binders and risk of infection-related and all-cause mortality in patients undergoing hemodialysis: The Q-Cohort Study. Reviewed International journal

    Yamada S, Tokumoto M, Taniguchi M, Yoshida H, Arase H, Tatsumoto N, Hirakata H, Kitazono T, Tsuruya K.

    Sci Rep.   2018.7

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  • Thrombolytic Therapy in Severe Cardioembolic Stroke After Reversal of Dabigatran with Idarucizumab: Case Report and Literature Review. Reviewed International journal

    Ohya Y, Makihara N, Wakisaka K, Morita T, Ago T, Kitazono T, Takaba H.

    J Stroke Cerebrovasc Dis.   2018.7

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  • Paradoxical Brain Embolism in Elderly Subjects with Small Atrial Septal Defects. Reviewed International journal

    Kitamura T, Arakawa S, Murao K, Kitazono T, Ago T.

    J Stroke Cerebrovasc Dis.   2018.7

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  • Impact of serum uric acid on incident hypertension in a worksite population of Japanese men. Reviewed International journal

    Kansui Y, Matsumura K, Morinaga Y, Inoue M, Kiyohara K, Ohta Y, Goto K, Ohtsubo T, Ooboshi H, Kitazono T.

    J Hypertens.   2018.7

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  • Metyrapone-responsive ectopic ACTH-secreting pheochromocytoma with a vicious cycle via a glucocorticoid-driven positive-feedback mechanism. Reviewed International journal

    Inoue M, Okamura K, Kitaoka C, Kinoshita F, Namitome R, Nakamura U, Shiota M, Goto K, Ohtsubo T, Matsumura K, Oda Y, Eto M, Kitazono T.

    Endocr J.   2018.7

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  • Effect of steroid pulse therapy on post-transplant immunoglobulin A nephropathy. Reviewed International journal

    Matsukuma Y, Masutani K, Tsuchimoto A, Okabe Y, Nakamura M, Kitazono T, Tsuruya K.

    Nephrology (Carlton).   2018.7

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  • Serum 1,25-Dihydroxyvitamin D Level Is Inappropriate for Use in Prospective Studies of Cancer Incidence - Reply. Reviewed International journal

    2018.7

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  • Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community. Reviewed International journal

    Yubi T, Hata J, Ohara T, Mukai N, Hirakawa Y, Yoshida D, Gotoh S, Hirabayashi N, Furuta Y, Ago T, Kitazono T, Kiyohara Y, Ninomiya T.

    Neurol Clin Pract.   2018.6

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  • Secular trends in the incidence of end-stage renal disease and its risk factors in Japanese patients with immunoglobulin A nephropathy. Reviewed International journal

    Tanaka S, Ninomiya T, Katafuchi R, Masutani K, Tsuchimoto A, Tokumoto M, Hirakata H, Ooboshi H, Kitazono T, Tsuruya K.

    Nephrol Dial Transplant.   2018.6

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  • Intensive Treat-to-Target Statin Therapy in High-Risk Japanese Patients With Hypercholesterolemia and Diabetic Retinopathy: Report of a Randomized Study. Reviewed International journal

    Itoh H, Komuro I, Takeuchi M, Akasaka T, Daida H, Egashira Y, Fujita H, Higaki J, Hirata KI, Ishibashi S, Isshiki T, Ito S, Kashiwagi A, Kato S, Kitagawa K, Kitakaze M, Kitazono T, Kurabayashi M, Miyauchi K, Murakami T, Murohara T, Node K, Ogawa S, Saito Y, Seino Y, Shigeeda T, Shindo S, Sugawara M, Sugiyama S, Terauchi Y, Tsutsui H, Ueshima K, Utsunomiya K, Yamagishi M, Yamazaki T, Yo S, Yokote K, Yoshida K, Yoshimura M, Yoshimura N, Nakao K, Nagai R; EMPATHY Investigators.

    Diabetes Care.   2018.6

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  • Secular trends in the incidence, risk factors, and prognosis of transient ischemic attack in Japan: The Hisayama Study. Reviewed International journal

    Furuta Y, Hata J, Mukai N, Hirakawa Y, Ago T, Kitazono T, Kiyohara Y, Ninomiya T.

    Atherosclerosis.   2018.6

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  • Association between serum albumin level and incidence of end-stage renal disease in patients with Immunoglobulin A nephropathy: A possible role of albumin as an antioxidant agent. Reviewed International journal

    Kawai Y, Masutani K, Torisu K, Katafuchi R, Tanaka S, Tsuchimoto A, Mitsuiki K, Tsuruya K, Kitazono T.

    PLoS One.   2018.5

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  • The EXPAND study: Efficacy and safety of rivaroxaban in Japanese patients with non-valvular atrial fibrillation. Reviewed International journal

    Shimokawa H, Yamashita T, Uchiyama S, Kitazono T, Shimizu W, Ikeda T, Kamouchi M, Kaikita K, Fukuda K, Origasa H, Sakuma I, Saku K, Okumura Y, Nakamura Y, Morimoto H, Matsumoto N, Tsuchida A, Ako J, Sugishita N, Shimizu S, Atarashi H, Inoue H.

    Int J Cardiol.   2018.5

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  • Development and validation of a risk assessment tool for gastric cancer in a general Japanese population. Reviewed International journal

    Iida M, Ikeda F, Hata J, Hirakawa Y, Ohara T, Mukai N, Yoshida D, Yonemoto K, Esaki M, Kitazono T, Kiyohara Y, Ninomiya T.

    Gastric Cancer.   2018.5

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  • Hemoglobin concentration and the risk of hemorrhagic and ischemic stroke in patients undergoing hemodialysis: the Q-cohort study. Reviewed International journal

    Yotsueda R, Tanaka S, Taniguchi M, Fujisaki K, Torisu K, Masutani K, Hirakata H, Kitazono T, Tsuruya K.

    Nephrol Dial Transplant.   2018.5

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  • A case of hyperparathyroidism-associated parkinsonism successfully treated with cinacalcet hydrochloride, a calcimimetic. Reviewed International journal

    Ohya Y, Osaki M, Sakai S, Kimura S, Yasuda C, Ago T, Kitazono T, Arakawa S.

    BMC Neurol.   2018.5

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  • Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Reviewed International journal

    Nat Genet.   2018.4

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  • A noninferiority confirmatory trial of prasugrel versus clopidogrel in Japanese patients with non-cardioembolic stroke: rationale and study design for a randomized controlled trial - PRASTRO-I trial. Reviewed International journal

    Nagao T, Toyoda K, Kitagawa K, Kitazono T, Yamagami H, Uchiyama S, Tanahashi N, Matsumoto M, Minematsu K, Nagata I, Nishikawa M, Nanto S, Abe K, Ikeda Y, Ogawa A.

    Expert Opin Pharmacother.   2018.4

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  • Outcome Prediction in Acute Stroke Patients by Continuous Glucose Monitoring. Reviewed International journal

    Wada S, Yoshimura S, Inoue M, Matsuki T, Arihiro S, Koga M, Kitazono T, Makino H, Hosoda K, Ihara M, Toyoda K.

    J Am Heart Assoc.   2018.4

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  • An improved inverse-type Ca2+ indicator can detect putative neuronal inhibition in Caenorhabditis elegans by increasing signal intensity upon Ca2+ decrease. Reviewed International journal

    Hara-Kuge S, Nishihara T, Matsuda T, Kitazono T, Teramoto T, Nagai T, Ishihara T.

    PLoS One.   2018.4

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  • Incidence of diabetic foot ulcer in Japanese patients with type 2 diabetes mellitus: The Fukuoka diabetes registry. Reviewed International journal

    Iwase M, Fujii H, Nakamura U, Ohkuma T, Ide H, Jodai-Kitamura T, Sumi A, Komorita Y, Yoshinari M, Kitazono T

    Diabetes Res Clin Pract   2018.3

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  • Comparing intracerebral hemorrhages associated with direct oral anticoagulants or warfarin. Reviewed International journal

    Kurogi R, Nishimura K, Nakai M, Kada A, Kamitani S, Nakagawara J, Toyoda K, Ogasawara K, Ono J, Shiokawa Y, Aruga T, Miyachi S, Nagata I, Matsuda S, Yoshimura S, Okuchi K, Suzuki A, Nakamura F, Onozuka D, Ido K, Kurogi A, Mukae N, Nishimura A, Arimura K, Kitazono T, Hagihara A, Iihara K; J-ASPECT Study Collaborators.

    Neurology.   2018.3

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  • Management of patients on antithrombotic agents undergoing emergency and elective endoscopy: joint Asian Pacific Association of Gastroenterology (APAGE) and Asian Pacific Society for Digestive Endoscopy (APSDE) practice guidelines. Reviewed International journal

    Chan FKL, Goh KL, Reddy N, Fujimoto K, Ho KY, Hokimoto S, Jeong YH, Kitazono T, Lee HS, Mahachai V, Tsoi KKF, Wu MS, Yan BP, Sugano K.

    Gut.   2018.3

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  • Design and baseline characteristics of the Xarelto Post-Authorization Safety & Effectiveness Study in Japanese Patients with Atrial Fibrillation (XAPASS). Reviewed International journal

    Ogawa S, Minematsu K, Ikeda T, Kitazono T, Nakagawara J, Miyamoto S, Murakawa Y, Ohashi Y, Takeichi M, Okayama Y, Yamanaka S, Inuyama L

    J Arrhythm   2018.2

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  • Association of geriatric nutritional risk index with infection-related mortality in patients undergoing hemodialysis: The Q-Cohort Study. Reviewed International journal

    Matsukuma Y, Tanaka S, Taniguchi M, Nakano T, Masutani K, Hirakata H, Kitazono T, Tsuruya K

    Clin Nutr   2018.2

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  • Impact of obstructive sleep apnea on blood pressure and cardiovascular risk factors in Japanese men: A cross-sectional study in work-site group. Reviewed International journal

    Morinaga Y, Matsumura K, Kansui Y, Sakata S, Goto K, Haga Y, Oishi E, Seki T, Ohtsubo T, Kitazono T

    Clin Exp Hypertens   2018.1

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  • Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi. Reviewed International journal

    Shijo M, Honda H, Suzuki SO, Hamasaki H, Hokama M, Abolhassani N, Nakabeppu Y, Ninomiya T, Kitazono T, Iwaki T

    Brain Pathol   2018.1

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  • Incidence of Hepatitis B Viral Reactivation After Kidney Transplantation With Low-Dose Rituximab Administration. Reviewed International journal

    Masutani K, Omoto K, Okumi M, Okabe Y, Shimizu T, Tsuruya K, Kitazono T, Nakamura M, Ishida H, Tanabe K; Japan Academic Consortium of Kidney Transplantation (JACK) Investigators

    Transplantation   2018.1

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  • Impact of obstructive sleep apnea on blood pressure and cardiovascular risk factors in Japanese men: A cross-sectional study in work-site group. Reviewed International journal

    Morinaga Y, Matsumura K, Kansui Y, Sakata S, Goto K, Haga Y, Oishi E, Seki T, Ohtsubo T, Kitazono T

    Clin Exp Hypertens   2018.1

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  • Albuminuria Increases the Risks for Both Alzheimer Disease and Vascular Dementia in Community-Dwelling Japanese Elderly: The Hisayama Study. Reviewed International journal

    Takae K, Hata J, Ohara T, Yoshida D, Shibata M, Mukai N, Hirakawa Y, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T

    J Am Heart Assoc   2018.1

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  • Endothelium-Dependent Hyperpolarization (EDH) in Hypertension: The Role of Endothelial Ion Channels. Reviewed International journal

    Goto K, Ohtsubo T, Kitazono T

    Int J Mol Sci   2018.1

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  • Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi. Reviewed International journal

    Shijo M, Honda H, Suzuki SO, Hamasaki H, Hokama M, Abolhassani N, Nakabeppu Y, Ninomiya T, Kitazono T, Iwaki T

    Brain Pathol   2018.1

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  • Role of renin-angiotensin aldosterone system on short-term blood pressure variability in hypertensive patients. Reviewed International journal

    Inoue M, Matsumura K, Haga Y, Kansui Y, Goto K, Ohtsubo T, Kitazono T

    Clin Exp Hypertens   2017.12

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  • Clinical characteristics of type A acute aortic dissection with CNS symptom. Reviewed International journal

    Shono Y, Akahoshi T, Mezuki S, Momii K, Kaku N, Maki J, Tokuda K, Ago T, Kitazono T, Maehara Y

    Am J Emerg Med   2017.12

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  • The ratio of serum eicosapentaenoic acid to arachidonic acid and riskツof cancer death in a Japanese community: The Hisayama Study. Reviewed International journal

    2017.12

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  • Association between the maximal distance of atrial septal protrusion and cryptogenic stroke. Reviewed International journal

    Tokunaga K, Yasaka M, Kuwashiro T, Gotoh S, Nakamura A, Takaguchi G, Ago T, Kamouchi M, Kitazono T, Okada Y

    Int J Stroke   2017.12

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  • Vascular endothelial growth factor-C ameliorates renal interstitial fibrosis through lymphangiogenesis in mouse unilateral ureteral obstruction. Reviewed International journal

    Hasegawa S, Nakano T, Torisu K, Tsuchimoto A, Eriguchi M, Haruyama N, Masutani K, Tsuruya K, Kitazono T

    Lab Invest   2017.12

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  • The gene-treatment interaction of paraoxonase-1 gene polymorphism and statin therapy on insulin secretion in Japanese patients with type 2 diabetes: Fukuoka diabetes registry. Reviewed International journal

    Sumi A, Nakamura U, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Komorita Y, Yoshinari M, Hirakawa Y, Hirano A, Kubo M, Kitazono T

    BMC Med Genet   2017.12

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  • Isolated and repeated stroke-like episodes in a middle-aged man with a mitochondrial ND3 T10158C mutation: a case report. Reviewed International journal

    Mezuki S, Fukuda K, Matsushita T, Fukushima Y, Matsuo R, Goto YI, Yasukawa T, Uchiumi T, Kang D, Kitazono T, Ago T

    BMC Neurol   2017.12

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  • Impact of blood urea nitrogen to creatinine ratio on mortality and morbidity in hemodialysis patients: The Q-Cohort Study. Reviewed International journal

    Tanaka S, Ninomiya T, Taniguchi M, Tokumoto M, Masutani K, Ooboshi H, Kitazono T, Tsuruya K

    Sci Rep   2017.11

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  • Asymptomatic Brain Edema after Hemodialysis Initiation in a Patient with Severe Uremia. Reviewed International journal

    Fujisaki K, Nakagawa K, Nagae H, Nakano T, Taniguchi M, Masutani K, Kitazono T, Tsuruya K

    Case Rep Med   2017.11

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  • Association of Airflow Limitation With Carotid Atherosclerosis in a Japanese Community- The Hisayama Study. Reviewed International journal

    Kudo K, Hata J, Matsumoto K, Shundo Y, Fukuyama S, Inoue H, Kitazono T, Kiyohara Y, Ninomiya T, Nakanishi Y

    Circ J   2017.11

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  • Association of Hypertriglyceridemia With the Incidence and Progression of Chronic Kidney Disease and Modification of the Association by Daily Alcohol Consumption. Reviewed International journal

    Tsuruya K, Yoshida H, Nagata M, Kitazono T, Iseki K, Iseki C, Fujimoto S, Konta T, Moriyama T, Yamagata K, Narita I, Kimura K, Kondo M, Asahi K, Ohashi Y, Watanabe T

    J Ren Nutr   2017.11

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  • White-coat and masked hypertension are associated with albuminuria in a general population: the Hisayama Study. Reviewed International journal

    Hata J, Fukuhara M, Sakata S, Arima H, Hirakawa Y, Yonemoto K, Mukai N, Kitazono T, Kiyohara Y, Ninomiya T

    Hypertens Res   2017.11

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  • Autophagy promotes degradation of internalized collagen and regulates distribution of focal adhesions to suppress cell adhesion. Reviewed International journal

    Kawano S, Torisu T, Esaki M, Torisu K, Matsuno Y, Kitazono T

    Biol Open   2017.11

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  • Association between serum uric acid level and renal arteriolar hyalinization in individuals without chronic kidney disease. Reviewed International journal

    Matsukuma Y, Masutani K, Tanaka S, Tsuchimoto A, Haruyama N, Okabe Y, Nakamura M, Tsuruya K, Kitazono T

    Atherosclerosis   2017.11

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  • A Case of Recurrent Ischemic Stroke due to Intravascular Lymphomatosis, Undiagnosed by Random Skin Biopsy and Brain Imaging. Reviewed International journal

    Ohya Y, Osaki M, Sakai S, Kimura S, Shimogamo T, Ago T, Kitazono T, Arakawa S

    Case Rep Neurol   182   2017.10

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  • Association between responsiveness to methoxy polyethylene glycol-epoetin beta and renal survival in patients with non-dialysis-dependent chronic kidney disease: A pooled analysis of individual patient-level data from clinical trials. Reviewed International journal

    Tsuruya K, Uemura Y, Hirakata H, Kitazono T, Tsubakihara Y, Suzuki M, Ohashi Y

    Nephrology (Carlton)   2017.10

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  • Morning and Evening Blood Pressures Are Associated With Intima-Media Thickness in a General Population縲- The Hisayama Study. Reviewed International journal

    2017.10

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  • Serum adiponectin predicts fracture risk in individuals with type 2 diabetes: the Fukuoka Diabetes Registry. Reviewed International journal

    Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Sumi A, Yoshinari M, Nakamura U, Kang D, Kitazono T

    Diabetologia   2017.10

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  • Multiple Signaling Pathways Coordinately Regulate Forgetting of Olfactory Adaptation through Control of Sensory Responses in Caenorhabditis elegans. Reviewed International journal

    Kitazono T, Hara-Kuge S, Matsuda O, Inoue A, Fujiwara M, Ishihara T

    J Neurosci   2017.10

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  • NADPH Oxidase-Related Pathophysiology in Experimental Models of Stroke. Reviewed International journal

    Yao H, Ago T, Kitazono T, Nabika T

    Int J Mol   2017.10

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  • Angiotensin II Receptor-Neprilysin Inhibitor Sacubitril/Valsartan Improves Endothelial Dysfunction in Spontaneously Hypertensive Rats. Reviewed International journal

    Seki T, Goto K, Kansui Y, Ohtsubo T, Matsumura K, Kitazono T

    J Am Heart Assoc   2017.10

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  • Repeated Paradoxical Brain Infarctions in a Patient on Self-Managed Home Hemodialysis Using a Long-Term Indwelling Catheter. Reviewed International journal

    Kiyohara T, Mizoguchi T, Kuroda J, Wakisaka Y, Irie A, Kitaoka C, Fujisaki K, Nakamura U, Tsuruya K, Kitazono T, Ago T

    J Stroke Cerebrovasc Dis   2017.9

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  • Characteristics of Primary and Metachronous Gastric Cancers Discovered after Helicobacter pylori Eradication: A Multicenter Propensity Score-Matched Study. Reviewed International journal

    Maehata Y, Nakamura S, Esaki M, Ikeda F, Moriyama T, Hida R, Washio E, Umeno J, Hirahashi M, Kitazono T, Matsumoto T

    Gut Liver   2017.9

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  • Comparison of Prognostic Values of Daytime and Night-Time Systolic Blood Pressures on Renal Outcomes in Patients With Chronic Kidney Disease. Reviewed International journal

    Katafuchi E, Nakayama M, Tanaka S, Sakoh T, Yoshitomi R, Fukui A, Seki M, Nakamata Y, Tominaga M, Tsuruya K, Kitazono T

    Circ J   2017.9

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  • Disruption of xanthine oxidoreductase gene attenuates renal ischemia reperfusion injury in mice. Reviewed International journal

    Haga Y, Ohtsubo T, Murakami N, Noguchi H, Kansui Y, Goto K, Matsumura K, Kitazono T

    Life Sci   182   73 - 79   2017.8

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  • The potential role of perivascular lymphatic vessels in preservation of kidney allograft function. Reviewed International journal

    Tsuchimoto A, Nakano T, Hasegawa S, Masutani K, Matsukuma Y, Eriguchi M, Nagata M, Nishiki T, Kitada H, Tanaka M, Kitazono T, Tsuruya K

    Clin Exp Nephrol   2017.8

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  • Association Between Serum Vitamin D and All-Cause and Cause-Specific Death in a General Japanese Population縲- The Hisayama Study. Reviewed International journal

    2017.8

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  • Modified Creatinine Index and the Risk of Bone Fracture in Patients Undergoing Hemodialysis: The Q-Cohort Study. Reviewed International journal

    Yamada S, Taniguchi M, Tokumoto M, Yoshitomi R, Yoshida H, Tatsumoto N, Hirakata H, Fujimi S, Kitazono T, Tsuruya K

    Am J Kidney Dis   2017.8

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  • The influence of CYP2C19 polymorphisms on exacerbating effect of rabeprazole in celecoxib-induced small bowel injury. Reviewed International journal

    Nuki Y, Umeno J, Washio E, Maehata Y, Hirano A, Miyazaki M, Kobayashi H, Kitazono T, Matsumoto T, Esaki M

    Aliment Pharmacol Ther   2017.8

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  • Alternative Measures of Hyperglycemia and Risk of Alzheimer's Disease in the Community: The Hisayama Study. Reviewed International journal

    Mukai N, Ohara T, Hata J, Hirakawa Y, Yoshida D, Kishimoto H, Koga M, Nakamura U, Kitazono T, Kiyohara Y, Ninomiya T

    J Clin Endocrinol Metab   2017.8

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  • Left Atrial Size and Long-Term Risk of Recurrent Stroke After Acute Ischemic Stroke in Patients With Nonvalvular Atrial Fibrillation. Reviewed International journal

    Ogata T, Matsuo R, Kiyuna F, Hata J, Ago T, Tsuboi Y, Kitazono T, Kamouchi M, FSR Investigators

    J Am Heart Assoc   2017.8

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  • Serum Non-High-Density Lipoprotein Cholesterol and Risk of Cardiovascular Disease in Community Dwellers with Chronic Kidney Disease: the Hisayama Study. Reviewed International journal

    Usui T, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Kitazono T, Kiyohara Y, Ninomiya T

    24   2017.7

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  • Cardiothoracic Ratio and All-Cause Mortality and Cardiovascular Disease Events in Hemodialysis Patients: The Q-Cohort Study. Reviewed International journal

    Yotsueda R, Taniguchi M, Tanaka S, Eriguchi M, Fujisaki K, Torisu K, Masutani K, Hirakata H, Kitazono T, Tsuruya K.

    70   2017.7

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  • Dietary Protein Intake and Stroke Risk in a General Japanese Population: The Hisayama Study. Reviewed International journal

    Ozawa M, Yoshida D, Hata J, Ohara T, Mukai N, Shibata M, Uchida K, Nagata M, Kitazono T, Kiyohara Y, Ninomiya T

    48   2017.6

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  • Comparison of cystatin C- and creatinine-based estimated glomerular filtration rates for predicting all-cause mortality in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry. Reviewed International journal

    Ide H, Iwase M, Fujii H, Ohkuma T, Kaizu S, Jodai T, Kikuchi Y, Idewaki Y, Sumi A, Nakamura U, Kitazono T

    Clin Exp Nephrol   2017.6

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  • The Fukuoka Kidney disease Registry (FKR) Study: design and methods. Reviewed International journal

    Tanaka S, Ninomiya T, Fujisaki K, Yoshida H, Nagata M, Masutani K, Tokumoto M, Mitsuiki K, Hirakata H, Fujimi S, Kiyohara Y, Kitazono T, Tsuruya K; Fukuoka Kidney disease Registry (FKR) Study Collaboration Group

    21   2017.6

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  • Comparison of cystatin C- and creatinine-based estimated glomerular filtration rates for predicting all-cause mortality in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry. Reviewed International journal

    Ide H, Iwase M, Fujii H, Ohkuma T, Kaizu S, Jodai T, Kikuchi Y, Idewaki Y, Sumi A, Nakamura U, Kitazono T

    21   2017.6

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  • Histological Analysis in ABO-Compatible and ABO-Incompatible Kidney Transplantation by Performance of 3- and 12-Month Protocol Biopsies. Reviewed International journal

    Masutani K, Tsuchimoto A, Kurihara K, Okabe Y, Kitada H, Okumi M, Tanabe K, Nakamura M, Kitazono T, Tsuruya K; Japan Academic Consortium of Kidney Transplantation (JACK) investigators

    101   2017.6

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  • Dura mater graft-associated Creutzfeldt-Jakob disease with 30-year incubation period. Reviewed International journal

    Shijo M, Honda H, Koyama S, Ishitsuka K, Maeda K, Kuroda J, Tanii M, Kitazono T, Iwaki T

    37   2017.6

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  • Trends in dementia prevalence, incidence, and survival rate in a Japanese community. Reviewed International journal

    Ohara T, Hata J, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y, Ninomiya T

    88   2017.5

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  • Trends in dementia prevalence, incidence, and survival rate in a Japanese community. Reviewed International journal

    Ohara T, Hata J, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y, Ninomiya T

    Neurology   2017.5

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  • Clinicopathological significance of monoclonal IgA deposition in patients with IgA nephropathy. Reviewed International journal

    Nagae H, Tsuchimoto A, Tsuruya K, Kawahara S, Shimomura Y, Noguchi H, Masutani K, Katafuchi R, Kitazono T

    21   2017.4

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  • Duodenal Neoplasms of Gastric Phenotype: An Immunohistochemical and Genetic Study With a Practical Approach to the Classification. Reviewed International journal

    Hida R, Yamamoto H, Hirahashi M, Kumagai R, Nishiyama K, Gi T, Esaki M, Kitazono T, Oda Y

    41   2017.3

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  • A J-shaped association between serum uric acid levels and poor renal survival in female patients with IgA nephropathy. Reviewed International journal

    Matsukuma Y, Masutani K, Tanaka S, Tsuchimoto A, Fujisaki K, Torisu K, Katafuchi R, Hirakata H, Tsuruya K, Kitazono T

    40   2017.3

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  • Total Phosphate Elimination is Negatively Associated With Increased Serum Fibroblast Growth Factor 23 Levels in Patients who Undergo Peritoneal Dialysis. Reviewed International journal

    Yamada S, Tsuruya K, Tokumoto M, Yoshida H, Tatsumoto N, Ooboshi H, Kitazono T

    21   2017.2

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  • Genetic Predisposition to Ischemic Stroke: A Polygenic Risk Score. Reviewed International journal

    Hachiya T, Kamatani Y, Takahashi A, Hata J, Furukawa R, Shiwa Y, Yamaji T, Hara M, Tanno K, Ohmomo H, Ono K, Takashima N, Matsuda K, Wakai K, Sawada N, Iwasaki M, Yamagishi K, Ago T, Ninomiya T, Fukushima A, Hozawa A, Minegishi N, Satoh M, Endo R, Sasaki M, Sakata K, Kobayashi S, Ogasawara K, Nakamura M, Hitomi J, Kita Y, Tanaka K, Iso H, Kitazono T, Kubo M, Tanaka H, Tsugane S, Kiyohara Y, Yamamoto M, Sobue K, Shimizu A

    48   2017.2

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  • Adverse Influence of Pre-Stroke Dementia on Short-Term Functional Outcomes in Patients with Acute Ischemic Stroke: The Fukuoka Stroke Registry. Reviewed International journal

    Wakisaka Y, Matsuo R, Hata J, Kuroda J, Kitazono T, Kamouchi M, Ago T; Fukuoka Stroke Registry Investigators.

    43   2017.1

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  • Modified Simple Peritoneal Wall Anchor Technique (PWAT) in Peritoneal Dialysis. Reviewed International journal

    Oka H, Yamada S, Kamimura T, Hara M, Hirashima Y, Matsueda S, Shukuri T, Aihara S, Koresawa M, Eriguchi M, Harada A, Tsuruya K, Kitazono T

    37   2017.1

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  • Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway. Reviewed International journal

    108   2017.1

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  • Cerebral Venous Thrombosis in the Superior Sagittal Sinus as a Rare Cause of a Paroxysmal Kinetic Tremor. Reviewed International journal

    Murao K, Arakawa S, Furuta Y, Shijo M, Ago T, Kitazono T

    8   2017.1

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  • Combination of Helicobacter pylori Antibody and Serum Pepsinogen as a Good Predictive Tool of Gastric Cancer Incidence: 20-Year Prospective Data From the Hisayama Study. Reviewed International journal

    Ikeda F, Shikata K, Hata J, Fukuhara M, Hirakawa Y, Ohara T, Mukai N, Nagata M, Yoshida D, Yonemoto K, Esaki M, Kitazono T, Kiyohara Y, Ninomiya T

    26   2016.12

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  • Comparison of steroid-pulse therapy and combined with mizoribine in IgA nephropathy: a randomized controlled trial. Reviewed International journal

    Masutani K, Tsuchimoto A, Yamada T, Hirakawa M, Mitsuiki K, Katafuchi R, Hirakata H, Kitazono T, Tsuruya K; West Japan Study Group for Therapy of IgA Nephropathy Investigators

    20   2016.12

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  • Inhibition of GSK-3β increases trabecular bone volume but not cortical bone volume in adenine-induced uremic mice with severe hyperparathyroidism. Reviewed International journal

    4   2016.11

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  • Associations of fibroblast growth factor 23 with urate metabolism in patients with chronic kidney disease. Reviewed International journal

    Sakoh T, Nakayama M, Tsuchihashi T, Yoshitomi R, Tanaka S, Katafuchi E, Fukui A, Shikuwa Y, Anzai N, Kitazono T, Tsuruya K

    65   2016.10

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  • The effect of renin-angiotensin system blockade on the incidence of end-stage renal disease in IgA nephropathy. Reviewed International journal

    Tanaka S, Ninomiya T, Katafuchi R, Masutani K, Nagata M, Tsuchimoto A, Hirakata H, Kitazono T, Tsuruya K

    20   2016.10

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  • Effects of smoking and its cessation on creatinine- and cystatin C-based estimated glomerular filtration rates and albuminuria in male patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry. Reviewed International journal

    Ohkuma T, Nakamura U, Iwase M, Ide H, Fujii H, Jodai T, Kaizu S, Kikuchi Y, Idewaki Y, Sumi A, Hirakawa Y, Kitazono T

    39   2016.10

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  • PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice. Reviewed International journal

    21   2016.10

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  • Association Between Serum Phosphate Levels and Stroke Risk in Patients Undergoing Hemodialysis: The Q-Cohort Study. Reviewed International journal

    Yamada S, Tsuruya K, Taniguchi M, Tokumoto M, Fujisaki K, Hirakata H, Fujimi S, Kitazono T.

    Stroke   49   2016.9

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  • Salt Intake, Home Blood Pressure, and Perinatal Outcome in Pregnant Women. Reviewed International journal

    Inoue M, Tsuchihashi T, Hasuo Y, Ogawa M, Tominaga M, Arakawa K, Oishi E, Sakata S, Ohtsubo T, Matsumura K, Kitazono T

    80   2016.9

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  • Association Between Diabetes and Hippocampal Atrophy in Elderly Japanese: The Hisayama Study. Reviewed International journal

    Hirabayashi N, Hata J, Ohara T, Mukai N, Nagata M, Shibata M, Gotoh S, Furuta Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Kiyohara Y, Ninomiya T.

    Diabetes Care   39   2016.9

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  • Serum Angiopoietin-Like Protein 2 Is a Novel Risk Factor for Cardiovascular Disease in the Community: The Hisayama Study. Reviewed International journal

    Hata J, Mukai N, Nagata M, Ohara T, Yoshida D, Kishimoto H, Shibata M, Hirakawa Y, Endo M, Ago T, Kitazono T, Oike Y, Kiyohara Y, Ninomiya T.

    Arterioscler Thromb Vasc Biol   36   2016.8

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  • Diagnosis and follow-up of posterior inferior cerebellar artery dissection complicated with ischemic stroke assisted by T1-VISTA: a report of two cases. Reviewed International journal

    Ishitsuka K, Sakaki Y, Sakai S, Uwatoko T, Aibe H, Ago T, Kitazono T, Sugimori H.

    BMC Neurol   16   2016.7

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  • Serum Uric Acid as a Risk Factor for Chronic Kidney Disease in a Japanese Community - The Hisayama Study. Reviewed International journal

    Takae K, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T

    80   2016.7

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  • Anti-Cyclic Citrullinated Peptide Antibody-Positive Meningoencephalitis in the Preclinical Period of Rheumatoid Arthritis. Reviewed International journal

    Shibahara T, Matsushita T, Matsuo R, Fukushima Y, Fukuda K, Sugimori H, Kamouchi M, Kitazono T, Ago T

    8   2016.7

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  • Genetic characteristics of inflammatory bowel disease in a Japanese population. Reviewed International journal

    Fuyuno Y, Yamazaki K, Takahashi A, Esaki M, Kawaguchi T, Takazoe M, Matsumoto T, Matsui T, Tanaka H, Motoya S, Suzuki Y, Kiyohara Y, Kitazono T, Kubo M.

    J Gastroenterol   51   2016.7

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  • Factors Associated with the Serum Myostatin Level in Patients Undergoing Peritoneal Dialysis: Potential Effects of Skeletal Muscle Mass and Vitamin D Receptor Activator Use. Reviewed International journal

    Yamada S, Tsuruya K, Yoshida H, Tokumoto M, Ueki K, Ooboshi H, Kitazono T.

    Calcif Tissue Int   99   2016.7

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  • Three-month risk-benefit profile of anticoagulation after stroke with atrial fibrillation: The SAMURAI-Nonvalvular Atrial Fibrillation (NVAF) study. Reviewed International journal

    Arihiro S, Todo K, Koga M, Furui E, Kinoshita N, Kimura K, Yamagami H, Terasaki T, Yoshimura S, Shiokawa Y, Kamiyama K, Takizawa S, Okuda S, Okada Y, Nagakane Y, Kameda T, Hasegawa Y, Shibuya S, Ito Y, Nakashima T, Takamatsu K, Nishiyama K, et al.

    Int J Stroke   11   2016.7

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  • Comparison of oral versus intravenous vitamin D receptor activator in reducing infection-related mortality in hemodialysis patients: the Q-Cohort Study. Reviewed International journal

    Tanaka S, Ninomiya T, Taniguchi M, Fujisaki K, Tokumoto M, Hirakata H, Ooboshi H, Kitazono T, Tsuruya K.

    Nephrol Dial Transplant.   31   2016.7

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  • Influence of Statin Pretreatment on Initial Neurological Severity and Short-Term Functional Outcome in Acute Ischemic Stroke Patients: The Fukuoka Stroke Registry. Reviewed International journal

    Ishikawa H, Wakisaka Y, Matsuo R, Makihara N, Hata J, Kuroda J, Ago T, Kitayama J, Nakane H, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators.

    Cerebrovasc Dis   42   2016.7

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  • The Successful Treatment of Calciphylaxis with Sodium Thiosulfate and Hyperbaric Oxygen in a Non-dialyzed Patient with Chronic Kidney Disease. Reviewed International journal

    Aihara S, Yamada S, Uchida Y, Arase H, Tsuchimoto A, Nakano T, Taniguchi M, Higashi H, Kitazono T, Tsuruya K.

    Intern Med   55   2016.7

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  • Plasma C-Reactive Protein and Clinical Outcomes after Acute Ischemic Stroke: A Prospective Observational Study. Reviewed International journal

    Matsuo R, Ago T, Hata J, Wakisaka Y, Kuroda J, Kuwashiro T, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators.

    PLoS One   11   2016.6

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  • Proton Pump Inhibitors Increase Incidence of Nonsteroidal Anti-Inflammatory Drug-Induced Small Bowel Injury: AツRandomized, Placebo-Controlled Trial. Reviewed International journal

    14   2016.6

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  • Detrimental role of pericyte Nox4 in the acute phase of brain ischemia. Reviewed International journal

    Nishimura A, Ago T, Kuroda J, Arimura K, Tachibana M, Nakamura K, Wakisaka Y, Sadoshima J, Iihara K, Kitazono T.

    J Cereb Blood Flow Metab   36   2016.6

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  • Comparison of the therapeutic efficacy and safety between tacrolimus and infliximab for moderate-to-severe ulcerative colitis: a single center experience. Reviewed International journal

    Nuki Y, Esaki M, Asano K, Maehata Y, Umeno J, Moriyama T, Nakamura S, Matsumoto T, Kitazono T.

    Scand J Gastroenterol   51   2016.6

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  • Light Chain Deposition Disease in an Older Adult Patient Successfully Treated with Long-term Administration of Bortezomib, Melphalan and Prednisone. Reviewed International journal

    Hiyamuta H, Yamada S, Matsukuma Y, Tsuchimoto A, Nakano T, Taniguchi M, Masutani K, Yoshimoto G, Muta T, Akashi K, Kitazono T, Tsuruya K.

    Intern Med   55   2016.5

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  • Subacute pulmonary embolism in a hemodialysis patient, successfully treated with surgical thrombectomy. Reviewed International journal

    Yamasaki K, Haruyama N, Taniguchi M, Nishida T, Tominaga R, Kitazono T, Tsuruya K

    5   2016.5

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  • [Pathogenetic mechanism of brain infarction]. Reviewed International journal

    Kitazono T.

    Nihon Rinsho   74   2016.4

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  • Extended Swan-Neck Catheter With Upper Abdominal Exit-Site Reduces Peritoneal Dialysis-Related Infections. Reviewed International journal

    Eriguchi M, Tsuruya K, Yoshida H, Haruyama N, Tanaka S, Tsuchimoto A, Fujisaki K, Torisu K, Masutani K, Kitazono T.

    Ther Apher Dial   20   2016.4

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  • Plasma B-type natriuretic peptide concentration is independently associated with kidney function decline in Japanese patients with chronic kidney disease. Reviewed International journal

    Yoshitomi R, Nakayama M, Sakoh T, Fukui A, Shikuwa Y, Tominaga M, Tsuchihashi T, Tsuruya K, Kitazono T.

    J Hypertens   34   2016.4

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  • Influenza Vaccination and Other Factors Related to the Development of Influenza-Like Illness Among Patients on Chronic Hemodialysis in a Japanese Dialysis Facility. Reviewed International journal

    Washio M, Higashi H, Sugawara K, Tsusumi C, Sakita M, Ide Y, Tsuruya K, Kitazono T, Kondo K, Ide S.

    Ther Apher Dial   20   2016.4

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  • Causes of Ischemic Stroke in Patients with Non-Valvular Atrial Fibrillation. Reviewed International journal

    Nakamura A, Kuroda J, Ago T, Hata J, Matsuo R, Arakawa S, Kuwashiro T, Yasaka M, Okada Y, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators.

    Cerebrovasc Dis   42   2016.4

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  • Trends in blood pressure control and medication use during 20 years in a hypertension clinic in Japan. Reviewed International journal

    Kansui Y, Ibaraki A, Goto K, Haga Y, Seki T, Takiguchi T, Ohtsubo T, Kitazono T, Matsumura K.

    Clin Exp Hypertens   38   2016.3

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  • Erythropoiesis-stimulating agent slows the progression of chronic kidney disease: a possibility of a direct action of erythropoietin. Reviewed International journal

    Tsuruya K, Yoshida H, Suehiro T, Fujisaki K, Masutani K, Kitazono T.

    Ren Fail   38   2016.3

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  • The long-term association between physical activity and risk of dementia in the community: the Hisayama Study. Reviewed International journal

    Kishimoto H, Ohara T, Hata J, Ninomiya T, Yoshida D, Mukai N, Nagata M, Ikeda F, Fukuhara M, Kumagai S, Kanba S, Kitazono T, Kiyohara Y.

    Eur J Epidemiol   31   2016.3

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  • Very low protein diet enhances inflammation, malnutrition, and vascular calcification in uremic rats. Reviewed International journal

    Yamada S, Tokumoto M, Tatsumoto N, Tsuruya K, Kitazono T, Ooboshi H.

    Life Sci   146   2016.2

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  • Effects of Lowering Dialysate Calcium Concentration on Mineral and Bone Disorders in Chronic Hemodialysis Patients: Conversion from 3.0 mEq/L to 2.75 mEq/L. Reviewed International journal

    20   2016.2

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  • Hypoalbuminemia, influenza vaccination and other factors related to the development of pneumonia acquired outside hospitals in southern Japan: A case-control study. Reviewed International journal

    Washio M, Kondo K, Fujisawa N, Harada E, Tashiro H, Mizokami T, Nogami H, Iwanaga T, Nakanishi Y, Suzuki K, Ohfuji S, Fukushima W, Hirota Y; Kyushu Task Force for CAP Risk in the Elderly.

    Geriatr Gerontol Int   16   2016.2

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  • Assessment of urinary angiotensinogen as a marker of podocyte injury in proteinuric nephropathies. Reviewed International journal

    Eriguchi M, Yotsueda R, Torisu K, Kawai Y, Hasegawa S, Tanaka S, Noguchi H, Masutani K, Kitazono T, Tsuruya K.

    Am J Physiol Renal Physiol   310   2016.2

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  • Prognostic value of chromosomal translocations in small-bowel diffuse large B-cell lymphoma. Reviewed International journal

    Ikegami K, Nakamura S, Esaki M, Yanai S, Hirahashi M, Oda Y, Takeshita M, Matsumoto T, Kitazono T

    Histopathology   68   199 - 209   2016.1

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  • Prognostic value of chromosomal translocations in small-bowel diffuse large B-cell lymphoma. Reviewed International journal

    Ikegami K, Nakamura S, Esaki M, Yanai S, Hirahashi M, Oda Y, Takeshita M, Matsumoto T, Kitazono T.

    Histopathology   68   2016.1

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  • Possible involvement of basic FGF in the upregulation of PDGFRホイ in pericytes after ischemic stroke. Reviewed International journal

    1630   2016.1

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  • [Intravascular Large B Cell Lymphoma with Cauda Equina Syndrome: A Case Report and Review of the Literature]. Reviewed International journal

    Wada S, Matsuo R, Matsushita T, Fukushima Y, Ago T, Kitazono T.

    Brain Nerve   68   2016.1

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  • Prognostic impact of serum bilirubin level on long-term renal survival in IgA nephropathy. Reviewed International journal

    Tanaka S, Ninomiya T, Masutani K, Nagata M, Tsuchimoto A, Tsuruya K, Kitazono T

    19   2015.12

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  • Spironolactone ameliorates arterial medial calcification in uremic rats: the role of mineralocorticoid receptor signaling in vascular calcification. Reviewed International journal

    Tatsumoto N, Yamada S, Tokumoto M, Eriguchi M, Noguchi H, Torisu K, Tsuruya K, Kitazono T

    309   2015.12

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  • Clinical significance of fronto-temporal gray matter atrophy in executive dysfunction in patients with chronic kidney disease: the VCOHP Study. Reviewed International journal

    Tsuruya K, Yoshida H, Haruyama N, Fujisaki K, Hirakata H, Kitazono T

    10   2015.12

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  • A multicenter, prospective, observational study of warfarin-associated intracerebral hemorrhage: The SAMURAI-WAICH study. Reviewed International journal

    Osaki M, Koga M, Maeda K, Hasegawa Y, Nakagawara J, Furui E, Todo K, Kimura K, Shiokawa Y, Okada Y, Okuda S, Kario K, Yamagami H, Minematsu K, Kitazono T, Toyoda K, et al.

    359   2015.12

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  • Impact of the Triglycerides to High-Density Lipoprotein Cholesterol Ratio on the Incidence and Progression of CKD: A Longitudinal Study in a Large Japanese Population. Reviewed International journal

    Tsuruya K, Yoshida H, Nagata M, Kitazono T, Iseki K, Iseki C, Fujimoto S, Konta T, Moriyama T, Yamagata K, Narita I, Kimura K, Kondo M, Asahi K, Kurahashi I, Ohashi Y, Watanabe T

    66   2015.12

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  • Association between eating rate and obesity: a systematic review and meta-analysis. Reviewed International journal

    Ohkuma T, Hirakawa Y, Nakamura U, Kiyohara Y, Kitazono T, Ninomiya T

    39   2015.11

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  • A hereditary enteropathy caused by mutations in the SLCO2A1 gene, encoding a prostaglandin transporter. Reviewed International journal

    Umeno J, Hisamatsu T, Esaki M, Hirano A, Kubokura N, Asano K, Kochi S, Yanai S, Fuyuno Y, Shimamura K, Hosoe N, Ogata H, Watanabe T, Aoyagi K, Watanabe K, Yasukawa S, Hirai F, Matsui T, Iida M, Yao T, Hibi T, Kosaki K, Kanai T, Kitazono T, Matsumoto T

    11   2015.11

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  • Association of genetically determined aldehyde dehydrogenase 2 Activity with diabetic complications in relation to alcohol consumption in Japanese patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry. Reviewed International journal

    Idewaki Y, Iwase M, Fujii H, Ohkuma T, Ide H, Kaizu S, Jodai T, Kikuchi Y, Hirano A, Nakamura U, Kubo M, Kitazono T

    10   2015.11

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  • Cardiorenal syndrome in end-stage kidney disease. Reviewed International journal

    Tsuruya K, Eriguchi M, Yamada S, Hirakata H, Kitazono T

    40   2015.11

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  • Midlife and late-life smoking and risk of dementia in the community: the Hisayama Study. Reviewed International journal

    Ohara T, Ninomiya T, Hata J, Ozawa M, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y

    63   2015.11

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  • Fetuin-A decrease induced by a low protein diet enhances vascular calcification in uremic rats with hyperphosphatemia. Reviewed International journal

    Yamada S, Tokumoto M, Tsuruya K, Tatsumoto N, Noguchi H, Kitazono T, Ooboshi H

    309   2015.10

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  • Hematocrit and the risk of cardiovascular disease in a Japanese community: the Hisayama Study. Reviewed International journal

    Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Ago T, Kitazono T, Kiyohara Y

    242   2015.9

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  • Factors associated with serum soluble inhibitors of Wnt-β-catenin signaling (sclerostin and dickkopf-1) in patients undergoing peritoneal dialysis. Reviewed International journal

    20   2015.9

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  • Association of serum total bilirubin with renal outcome in Japanese patients with stages 3-5 chronic kidney disease. Reviewed International journal

    Sakoh T, Nakayama M, Tanaka S, Yoshitomi R, Ura Y, Nishimoto H, Fukui A, Shikuwa Y, Tsuruya K, Kitazono T

    64   2015.9

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  • Two years of cinacalcet hydrochloride treatment decreased parathyroid gland volume and serum parathyroid hormone level in hemodialysis patients with advanced secondary hyperparathyroidism. Reviewed International journal

    Yamada S, Tokumoto M, Taniguchi M, Toyonaga J, Suehiro T, Eriguchi R, Fujimi S, Ooboshi H, Kitazono T, Tsuruya K

    19   2015.8

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  • A genome-wide association study of late-onset Alzheimer's disease in a Japanese population. Reviewed International journal

    Hirano A, Ohara T, Takahashi A, Aoki M, Fuyuno Y, Ashikawa K, Morihara T, Takeda M, Kamino K, Oshima E, Okahisa Y, Shibata N, Arai H, Akatsu H, Ikeda M, Iwata N, Ninomiya T, Monji A, Kitazono T, Kiyohara Y, Kubo M, Kanba S

    25   2015.8

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  • Relationship between salt intake as estimated by a brief self-administered diet-history questionnaire (BDHQ) and 24-h urinary salt excretion in hypertensive patients. Reviewed International journal

    Sakata S, Tsuchihashi T, Oniki H, Tominaga M, Arakawa K, Sakaki M, Kitazono T

    38   2015.8

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  • Systemic aldosterone, but not angiotensin II, plays a pivotal role in the pathogenesis of renal injury in chronic nitric oxide-deficient male rats. Reviewed International journal

    Suehiro T, Tsuruya K, Ikeda H, Toyonaga J, Yamada S, Noguchi H, Tokumoto M, Kitazono T

    156   2015.7

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  • Day-by-Day Blood Pressure Variability and Functional Outcome After Acute Ischemic Stroke: Fukuoka Stroke Registry. Reviewed International journal

    Fukuda K, Kai H, Kamouchi M, Hata J, Ago T, Nakane H, Imaizumi T, Kitazono T; FSR Investigators; steering committee of the Fukuoka Stroke Registry included

    46   2015.7

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  • Association of hemoglobin A1c and glycated albumin with carotid atherosclerosis in community-dwelling Japanese subjects: the Hisayama Study. Reviewed International journal

    Mukai N, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y

    14   2015.6

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  • Effects of hydrochlorothiazide on oxidative stress and pulse pressure in hypertensive patients with chronic stroke: the EMINENT study. Reviewed International journal

    Nakane H, Kamouchi M, Hata J, Ibayashi S, Kusuda K, Omae T, Nagao T, Ago T, Kitazono T; EMINENT Study Investigators

    54   2015.6

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  • Risk of cancer in the rectal remnant after ileorectal anastomosis in patients with familial adenomatous polyposis: single center experience. Reviewed International journal

    Maehata Y, Esaki M, Nakamura S, Hirahashi M, Ueki T, Iida M, Kitazono T, Matsumoto T

    27   2015.5

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  • Association of severe hypoglycemia with depressive symptoms in patients with type 2 diabetes: the Fukuoka Diabetes Registry. Reviewed International journal

    Kikuchi Y, Iwase M, Fujii H, Ohkuma T, Kaizu S, Ide H, Jodai T, Idewaki Y, Nakamura U, Kitazono T

    3   2015.5

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  • Phosphate binders prevent phosphate-induced cellular senescence of vascular smooth muscle cells and vascular calcification in a modified, adenine-based uremic rat model. Reviewed International journal

    Yamada S, Tatsumoto N, Tokumoto M, Noguchi H, Ooboshi H, Kitazono T, Tsuruya K

    Calcif Tissue Int   96   2015.4

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  • Clinicopathologic features of chronic nonspecific multiple ulcers of the small intestine. Reviewed International journal

    Esaki M, Umeno J, Kitazono T, Matsumoto T

    8   2015.4

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  • Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo. Reviewed International journal

    Kubokura N, Takahashi-Yanaga F, Arioka M, Yoshihara T, Igawa K, Tomooka K, Morimoto S, Nakatsu Y, Tsuzuki T, Nakabeppu Y, Matsumoto T, Kitazono T, Sasaguri T

    127   2015.4

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  • Nonconvulsive partial status epilepticus mimicking recurrent infarction revealed by diffusion-weighted and arterial spin labeling perfusion magnetic resonance images. Reviewed International journal

    Kanazawa Y, Morioka T, Arakawa S, Furuta Y, Nakanishi A, Kitazono T

    24   2015.4

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  • Hyporesponsiveness to erythropoiesis-stimulating agent as a prognostic factor in Japanese hemodialysis patients: the Q-Cohort study. Reviewed International journal

    Eriguchi R, Taniguchi M, Ninomiya T, Hirakata H, Fujimi S, Tsuruya K, Kitazono T

    28   2015.4

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  • Angiotensin I-converting enzyme gene polymorphism enhances the effect of hypercholesterolemia on the risk of coronary heart disease in a general Japanese population: the hisayama study. Reviewed International journal

    Kondo H, Ninomiya T, Hata J, Hirakawa Y, Yonemoto K, Arima H, Nagata M, Tsuruya K, Kitazono T, Kiyohara Y

    J Atheroscler Thromb   22   2015.4

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  • Sex differences in short-term outcomes after acute ischemic stroke: the fukuoka stroke registry. Reviewed International journal

    Irie F, Kamouchi M, Hata J, Matsuo R, Wakisaka Y, Kuroda J, Ago T, Kitazono T; FSR Investigators

    Stroke   46   2015.2

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  • Subsequent vascular events after ischemic stroke: the Japan Statin Treatment Against Recurrent Stroke-Longitudinal. Reviewed International journal

    Nomura E, Suzuki A, Inoue I, Nakagawara J, Takahashi K, Takahashi T, Manabe Y, Yokota C, Okada K, Nishihara T, Yamamoto Y, Noda K, Takahashi S, Ibayashi S, Takagi M, Kitagawa K, Tanahashi N, Kuriyama M, Hirata K, Hosomi N, Minematsu K, Kobayashi S, Matsumoto M; J-STARS-L Investigators

    J Stroke Cerebrovasc Dis   24   2015.2

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  • Involvement of platelet-derived growth factor receptor β in fibrosis through extracellular matrix protein production after ischemic stroke. Reviewed International journal

    264   2015.2

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  • Dietary patterns and clinical outcomes in hemodialysis patients in Japan: a cohort study. Reviewed International journal

    Tsuruya K, Fukuma S, Wakita T, Ninomiya T, Nagata M, Yoshida H, Fujimi S, Kiyohara Y, Kitazono T, Uchida K, Shirota T, Akizawa T, Akiba T, Saito A, Fukuhara S

    10   2015.1

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  • Possible involvement of basic FGF in the upregulation of PDGFRβ in pericytes after ischemic stroke. Reviewed International journal

    1930   2015.1

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  • Therapeutic strategy for Crohn's disease with a loss of response to infliximab: a single-center retrospective study. Reviewed International journal

    Nagata Y, Esaki M, Umeno J, Fuyuno Y, Ikegami K, Maehata Y, Asano K, Moriyama T, Nakamura S, Kitazono T,Matsumoto T

    Digestion   91   50 - 56   2015.1

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  • Importance of specific reference values for evaluation of the deteriorating thyroid function in patients with end-stage renal disease on hemodialysis. Reviewed International journal

    Sanai T, Okamura K, Kishi T, Miyazono M, Ikeda Y, Kitazono T

    J Endocriol Invest   38   47 - 56   2015.1

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  • Hypercalcemia induced by Rosai-Dorfman disease in a hemodialysis patient: histological evidence of extrarenal calcitriol overproduction. Reviewed International journal

    Yamada S, Uemura M, Tokumoto M, Nagara T, Noguchi H, Hirahashi M, Nakano T, Tsuruya K, Kitazono T

    Intern Med   53   2014.12

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  • Statin inhibits the expression of secretory phospholipase A2 and subsequent monocyte chemoattractant protein-1 in human endothelial cells. Reviewed International journal

    Sonoki K, Iwase M, Ohdo S, Ieiri I, Takata Y, Kitazono T

    J Cardiovasc Pharmacol   64   2014.12

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  • Intravenous thrombolysis with recombinant tissue plasminogen activator for ischemic stroke patients over 80 years old: the Fukuoka Stroke Registry. Reviewed International journal

    Matsuo R, Kamouchi M, Fukuda H, Hata J, Wakisaka Y, Kuroda J, Ago T, Kitazono T; FSR Investigators

    PLoS One   9   2014.10

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  • Significance of plasma adiponectin for diagnosis, neurological severity and functional outcome in ischemic stroke - Research for Biomarkers in Ischemic Stroke (REBIOS). Reviewed International journal

    Kuwashiro T, Ago T, Kamouchi M, Matsuo R, Hata J, Kuroda J, Fukuda K, Sugimori H, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T

    Metabolism   63   2014.9

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  • Gastrointestinal bleeding in acute ischemic stroke: recent trends from the fukuoka stroke registry. Reviewed International journal

    Ogata T, Kamouchi M, Matsuo R, Hata J, Kuroda J, Ago T, Sugimori H, Inoue T, Kitazono T; Fukuoka Stroke Registry

    Cerebrovasc Dis Extra   4   2014.7

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  • Nox4 is a major source of superoxide production in human brain pericytes. Reviewed International journal

    Kuroda J, Ago T, Nishimura A, Nakamura K, Matsuo R, Wakisaka Y, Kamouchi M, Kitazono T

    J Vasc Res   51   2014.6

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  • U-shaped association of sleep duration with metabolic syndrome and insulin resistance in patients with type 2 diabetes: the Fukuoka Diabetes Registry. Reviewed International journal

    Ohkuma T, Fujii H, Iwase M, Ogata-Kaizu S, Ide H, Kikuchi Y, Idewaki Y, Jodai T, Hirakawa Y, Nakamura U, Kitazono T

    Metabolism   63   2014.4

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  • Cerebral oxidative stress induces spatial working memory dysfunction in uremic mice: neuroprotective effect of tempol. Reviewed International journal

    Fujisaki K, Tsuruya K, Yamato M, Toyonaga J, Noguchi H, Nakano T, Taniguchi M, Tokumoto M, Hirakata H, Kitazono T

    Nephrol Dial Transplant   29   2014.3

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  • Serum 1,25-dihydroxyvitamin d and the development of kidney dysfunction in a Japanese community. Reviewed International journal

    Izumaru K, Ninomiya T, Nagata M, Usui T, Yoshida D, Yonemoto K, Fukuhara M, Tsuruya K, Kitazono T, Kiyohara Y

    Circ J   78   2014.3

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  • Trends in the prevalence of type 2 diabetes and prediabetes in community-dwelling Japanese subjects: The Hisayama Study. Reviewed International journal

    Mukai N, Doi Y, Ninomiya T, Hirakawa Y, Nagata M, Yoshida D, Hata J, Fukuhara M, Nakamura U, Kitazono T, Kiyohara Y

    J Diabetes Investig   5   2014.3

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  • Trends in the incidence and survival of intracerebral hemorrhage by its location in a Japanese community. Reviewed International journal

    Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Shikata K, Kamouchi M, Kitazono T, Kiyohara Y

    Circ J   78   2014.2

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  • ABCD3 and ABCD3-I scores are superior to ABCD2 score in the prediction of short- and long-term risks of stroke after transient ischemic attack. Stroke. Reviewed International journal

    Kiyohara T, Kamouchi M, Kumai Y, Ninomiya T, Hata J, Yoshimura S, Ago T, Okada Y, Kitazono T

    Stroke   45   2014.2

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  • Statins and the risks of stroke recurrence and death after ischemic stroke: the Fukuoka Stroke Registry. Reviewed International journal

    Makihara N, Kamouchi M, Hata J, Matsuo R, Ago T, Kuroda J, Kuwashiro T, Sugimori H, Kitazono T; Fukuoka Stroke Registry Investigators

    Atherosclerosis   231   2013.12

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  • Impact of dietary fiber intake on glycemic control, cardiovascular risk factors and chronic kidney disease in Japanese patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry. Reviewed International journal

    Fujii H, Iwase M, Ohkuma T, Ogata-Kaizu S, Ide H, Kikuchi Y, Idewaki Y, Joudai T, Hirakawa Y, Uchida K, Sasaki S, Nakamura U, Kitazono T

    Nutr J   12   2013.12

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  • Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: the Hisayama Study. Reviewed International journal

    Ninomiya T, Nagata M, Hata J, Hirakawa Y, Ozawa M, Yoshida D, Ohara T, Kishimoto H, Mukai N, Fukuhara M, Kitazono T, Kiyohara Y

    Atherosclerosis   231   2013.12

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  • Acute kidney injury and edaravone in acute ischemic stroke: the Fukuoka Stroke Registry. Reviewed International journal

    Kamouchi M, Sakai H, Kiyohara Y, Minematsu K, Hayashi K, Kitazono T

    J Stroke Cerebrovasc Dis   22   2013.11

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  • Predictive role of C reactive protein in stroke recurrence after cardioembolic stroke: the Fukuoka Stroke Registry. Reviewed International journal

    Kuwashiro T, Sugimori H, Ago T, Kuroda J, Kamouchi M, Kitazono T; FSR Investigators

    BMJ Open   3   2013.11

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  • Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general Japanese population: the Hisayama Study. Reviewed International journal

    Ikeda F, Doi Y, Ninomiya T, Hirakawa Y, Mukai N, Hata J, Shikata K, Yoshida D, Matsumoto T, Kitazono T, Kiyohara Y

    Cardiovasc Diabetol   12   2013.11

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  • Association of deep venous thrombosis with calf vein diameter in acute hemorrhagic stroke. Reviewed International journal

    Ogata T, Yasaka M, Wakugawa Y, Kitazono T

    J Stroke Cerebrovasc Dis   22   2013.10

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  • Impact of allele copy number of polymorphisms in FCGR3A and FCGR3B genes on susceptibility to ulcerative colitis. Reviewed International journal

    Asano K, Matsumoto T, Umeno J, Hirano A, Esaki M, Hosono N, Matsui T, Kiyohara Y, Nakamura Y, Kubo M, Kitazono T

    Inflamm Bowel Dis   19   2013.9

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  • Angiopoietin-like protein 2 is associated with chronic kidney disease in a general Japanese population: the Hisayama Study. Reviewed International journal

    Usui T, Ninomiya T, Nagata M, Takahashi O, Doi Y, Hata J, Fukuhara M, Kitazono T, Oike Y, Kiyohara Y

    Circ J   77   2013.9

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  • Progression of right internal carotid artery stenosis in ischemic stroke patient with autoimmune polyglandular syndrome: A case report. Reviewed International journal

    Kanazawa Y, Matsuo R, Fukushima Y, Fukuda K, Kamouchi M, Kitazono T

    Rinsho Shinkeigaku   53   2013.7

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  • Slowly progressive and painless thoracic aortic dissection presenting with a persistent Fever in an elderly patient: the usefulness of combined measurement of biochemical parameters. Reviewed International journal

    Yamada S, Tokumoto M, Ohkuma T, Kansui Y, Wakisaka Y, Uchizono Y, Tsuruya K, Kitazono T, Ooboshi H

    Case Rep Med   2013   2013.6

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  • The clinical utility of serum tartrate-resistant acid phosphatase 5b in the assessment of bone resorption in patients on peritoneal dialysis. Reviewed International journal

    Yamada S, Tsuruya K, Yoshida H, Taniguchi M, Haruyama N, Tanaka S, Eriguchi M, Nakano T, Kitazono T.

    Clin Endocrinol (Oxf)   78   2013.6

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  • The impact of predisposing factors on long-term outcome after stroke in diabetic patients: the Fukuoka Stroke Registry. Reviewed International journal

    Kuwashiro T, Sugimori H, Ago T, Kuroda J, Kamouchi M, Kitazono T

    Eur J Neurol   20   2013.6

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  • White-coat and masked hypertension are associated with carotid atherosclerosis in a general population: the Hisayama study. Reviewed International journal

    Fukuhara M, Arima H, Ninomiya T, Hata J, Hirakawa Y, Doi Y, Yonemoto K, Mukai N, Nagata M, Ikeda F, Matsumura K, Kitazono T, Kiyohara Y

    Stroke   44   2013.6

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  • Temporal trends in sudden unexpected death in a general population: the Hisayama study. Reviewed International journal

    Nagata M, Ninomiya T, Doi Y, Hata J, Ikeda F, Mukai N, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y

    Am Heart J   165   2013.6

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  • Regression of tumoral calcinosis after the appropriate control of a deranged mineral and bone metabolism, in conjugation with cinacalcet hydrochloride treatment, in a chronic hemodialysis patient. Reviewed International journal

    Yamada S, Tsuruya K, Kitazono T

    Ther Apher Dial   17   2013.6

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  • Dietary patterns and risk of dementia in an elderly Japanese population: the Hisayama Study. Reviewed International journal

    Ozawa M, Ninomiya T, Ohara T, Doi Y, Uchida K, Shirota T, Yonemoto K, Kitazono T, Kiyohara Y

    Am J Clin Nutr   97   2013.5

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  • Clinical significance of plasma VEGF value in ischemic stroke - research for biomarkers in ischemic stroke (REBIOS) study. Reviewed International journal

    Matsuo R, Ago T, Kamouchi M, Kuroda J, Kuwashiro T, Hata J, Sugimori H, Fukuda K, Gotoh S, Makihara N, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T

    BMC Neurol   13   2013.4

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  • RANTES has a potential to play a neuroprotective role in an autocrine/paracrine manner after ischemic stroke. Reviewed International journal

    Tokami H, Ago T, Sugimori H, Kuroda J, Awano H, Suzuki K, Kiyohara Y, Kamouchi M, Kitazono T

    Brain Res   2013.4

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  • Brachial-ankle pulse wave velocity predicts the development of cardiovascular disease in a general Japanese population: the Hisayama Study. Reviewed International journal

    Ninomiya T, Kojima I, Doi Y, Fukuhara M, Hirakawa Y, Hata J, Kitazono T, Kiyohara Y

    J Hypertens   31   2013.3

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  • Risk score for predicting recurrence in patients with ischemic stroke: the fukuoka stroke risk score for Japanese. Reviewed International journal

    Kamouchi M, Kumagai N, Okada Y, Origasa H, Yamaguchi T, Kitazono T

    Cerebrovasc Dis   34   2012.11

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  • Association between glucose tolerance level and cancer death in a general Japanese Population: the Hisayama Study. Reviewed International journal

    Hirakawa Y, Ninomiya T, Mukai N, Doi Y, Hata J, Fukuhara M, Iwase M, Kitazono T, Kiyohara Y

    Am J Epidemiol   176   2012.11

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  • Insulin resistance and the development of cardiovascular disease in a Japanese community: the Hisayama Study. Reviewed International journal

    Gotoh S, Doi Y, Hata J, Ninomiya T, Mukai N, Fukuhara M, Kamouchi M, Kitazono T, Kiyohara Y

    J Atheroscler Thromb   19   2012.11

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  • Lower levels of high-density lipoprotein cholesterol on admission and a recurrence of ischemic stroke: A 12-month follow-up of the Fukuoka Stroke Registry. Reviewed International journal

    Kuwashiro T, Sugimori H, Kamouchi M, Ago T, Kitazono T, Iida M

    J Stroke Cerebrovasc Dis   21   2012.10

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  • Antegrade internal cartoidartery collateral flow and cerebral blood flow in patients with common cartoid artery occlusion. Reviewed International journal

    Nakamura A, Wakugawa Y, Yasaka M, Ogata T, Yasumori K, Kitazono T, Okada Y

    J Ultrasound Med   31   2012.10

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  • Self-reported dietary intake of potassium, calcium, and magnesium and risk of dementia in the Japanese: the Hisayama Study. Reviewed International journal

    Ozawa M, Ninomiya T, Ohara T, Hirakawa Y, Doi Y, Hata J, Uchida K, Shirota T, Kitazono T, Kiyohara Y

    JAGS   60   2012.8

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  • Optimal cutoff value of the serum pepsinogen level for prediction of gastric cancer incidence: the Hisayama Study. Reviewed International journal

    Shikata K, Ninomiya T, Yonemoto K, Ikeda F, Hata J, Doi Y, Fukuhara M, Matsumoto T, Iida M, Kitazono T, Kiyohara Y

    Scand J Gastroenterol   47   2012.6

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  • Impact of lower range of prehypertension on cardiovascular events in a general population: the Hisayama Study. Reviewed International journal

    Fukuhara M, Arima H, Ninomiya T, Hata J, Yonemoto K, Doi Y, Hirakawa Y, Matsumura K, Kitazono T, Kiyohara Y.

    J Hypertens   30   2012.5

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  • Neurotrophin production in brain pericytes during hypoxia: a role of pericytes for neuroprotection. Reviewed International journal

    Ishitsuka K, Ago T, Arimura K, Nakamura K, Tokami H, Makihara N, Kuroda J, Kamouchi M, Kitazono T.

    Microvasc Res   83 ( 3 )   2012.5

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  • The factors associated with a functional outcome after ischemic stroke in diabetic patients: the Fukuoka Stroke Registry. Reviewed International journal

    Kuwashiro T, Kamouchi M, Ago T, Hata J, Sugimori H, Kitazono T.

    J Neurol Sci   313   2012.2

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  • Risk factors predisposing to stroke recurrence within one year of non-cardioembolic stroke onset: The Fukuoka Stroke Registry. Reviewed International journal

    Kuwashiro T, Sugimori H, Ago T, Kamouchi M, Kitazono T, for the FSR Investigators.

    Cerebrovasc Dis   33   2012.2

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  • Long-term results of medical and surgical therapy for Japanese patients with moderate carotid stenosis. Reviewed International journal

    Ogata T, Yasaka M, Wakugawa Y, Inoue T, Yasumori K, Kitazono T, Iida M, Okada Y.

    J Stroke Cerebrovasc Dis   21 ( 1 )   2012.1

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  • Differences in diffusion-weighted image and transesophageal echocardiographical findings in cardiogenic, paradoxical and aortogenic brain embolism. Reviewed International journal

    Fujimoto S, Toyoda K, Jinnouchi J, Yasaka M, Kitazono T, Okada Y.

    Cerebrovasc Dis   32 ( 2 )   2011.7

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  • Lower levels of high-density lipoprotein cholesterol on admission and a recurrence of ischemic stroke: a 12-month follow-up of the Fukuoka Stroke Registry. Reviewed International journal

    Kuwashiro T, Sugimori H, Kamouchi M, Ago T, Kitazono T, Iida M

    J Stroke Cerebrovasc Dis   2011.3

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  • Combined effects of smoking and hypercholesterolemia on the risk of stroke and coronary heart disease in Japanese: the Hisayama Study. Reviewed International journal

    Hata J, Doi Y, Ninomiya T, Fukuhara M, Ikeda F, Mukai N, Hirakawa Y, Kitazono T, Kiyohara Y.

    Cerebrovasc Dis   31 ( 5 )   2011.3

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  • Outcomes associated with carotid pseudo-occlusion. Reviewed International journal

    Ogata T, Yasaka M, Kanazawa Y, Wakugawa Y, Inoue T, Yasumori K, Kitazono T, Okada Y.

    Cerebrovasc Dis   31 ( 5 )   2011.3

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  • Prognosis of medical treatment for Japanese patients with carotid stenosis. Reviewed International journal

    Ogata T, Yasaka M, Wakugawa Y, Yasumori K, Kitazono T, Okada Y.

    Intern Med   50 ( 4 )   2011.2

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  • Morphological classification of mobile plaques and their association with early recurrence of stroke. Reviewed International journal

    Ogata T, Yasak M, Wakugawa Y, Inoue T, Kitazono T, Okada Y.

    Cerebrovasc Dis   30 ( 6 )   2010.10

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  • Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population. Reviewed International journal

    Matsushita T, Umeno J, Hirakawa Y, Yonemoto K, Ashikawa K, Amitani H, Ninomiya T, Hata J, Doi Y, Kitaozono T, Iida M, Nakamura Y, Kiyohara Y, Kubo M.

    J Hum Genet   55 ( 7 )   2010.7

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  • The effect of metabolic syndrome defined by various criteria on the development of ischemic stroke subtypes in a general Japanese population. Reviewed International journal

    Hata J, Doi Y, Ninomiya T, Tanizaki Y, Yonemoto K, Fukuoara M, Kubo M, Kitazono T, Iida M, Kiyohara Y.

    Atherosclerosis   210 ( 1 )   2010.5

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  • Change in intracellular pH causes the toxic Ca2+ entry via NCX1 in neuron- and glia-derived cells. Reviewed International journal

    Shono Y, Kamouchi M, Kitazono, T, Kuroda J, Nakamura K, Hagiwara N, Ooboshi H, Ibayashi S, Iida M

    Cell Mol Neurobiol   30 ( 3 )   2010.4

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  • Midkine gene transfer protects against focal brain ischemia and augments neurogenesis. Reviewed International journal

    Ishikawa E, Ooboshi H, Kumai Y, Takada J, Nakamura K, Ago T, Sugimori H, Kamouchi M, Kitazono T, Ibayashi S, Iida M

    J Neurol Sci   285 ( 1 )   2009.10

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  • The role of redox modulation of class II histone deacetylases in mediation pathological cardiac hypertrophy. Reviewed International journal

    Oka S, Ago T, Kitazono T, Zablocki D, Sadoshima J

    J Mol Med   87 ( 8 )   2009.8

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  • Flow volume and cross-sectional area of the extracranial vertebral arteries and its relation to vascular lesions or anatomical variation in the posterior circulation. Reviewed International journal

    Wakugawa Y, Sugimori H, Nakane H, Hata J, Irie K, Kitazono T, Iida M

    Ultrasound Med Biol   35 ( 7 )   2009.7

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  • Amiloride inhibits hydrogen peroxide-induced Ca2+ responses in human CNS pericytes. Reviewed International journal

    Nakamura K, Kamouchi M, Kitazono T, Kuroda J, Shono Y, Hagiwara N, Ago T, Ooboshi H, Ibayashi S, Iida M

    Microvasc Res   77 ( 3 )   2009.5

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  • Lack of association between variation of PDE4D and ischemic stroke in the Japanese population. Reviewed International journal

    Matsushita T, Kubo M, Yonemoto K, Ninomiya T, Ashikawa K, Liang B, Hata J, Doi Y, Kitazono T, Ibayashi S, Iida M, Kiyohara Y, Nakamura Y

    Stroke   40 ( 4 )   2009.4

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  • Cerebral venous thrombosis associated with iron deficiency anemia. Reviewed International journal

    Ogata T, Kamouchi M, Kitazono T, Kuroda J, Ooboshi H, Shono T, Morioka T, Ibayashi S, Sasaki T, Iida M.

    J Stroke Cereb Dis   17 ( 6 )   2008.11

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  • Polymorphism in the sorbin and SH3-domain- containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population: the Fukuoka Stroke Registry and the Hisayama Study Reviewed International journal

    Hagiwara N, Kitazono T, Kamouchi M, Kuroda J, Ago T, Hata J, Ninomiya T, Ooboshi H, Kumai Y, Yoshimura S, Tamaki K, Fujii K, Nagao T, Okada Y, Toyoda K, Nakane H, Sigimori H, Yamashita Y, Kubo M, Tanizaki Y, Kiyohara Y, Ibayashi S, Iida M

    European Journal of Neurology   2008.5

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  • Protective effects of angiotensin II type 1 receptor blocker on cerebral circulation independent of blood pressure Reviewed International journal

    Kumai Y, Ooboshi H, Ago T, Ishikawa E, Takada J, Kamouchi M, Kitazono T, Ibayashi S, Iida M

    Experimental Neurology   2008.4

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  • Polymorphisms in the lymphotoxin alpha gene and the risk of ischemic stroke in the Japanese population: the Fukuoka Stroke Registry and the Hisayama Study Reviewed International journal

    Hagiwara N, Kitazono T, Kamouchi M, Kuroda J, Ago T, Hata J, Ninbomiya T, Ooboshi H, Kumai Y, Yoshimura S, Tamaki K, Fujii K, Nagao T, Okada Y, Toyoda K, Nakane H, Sugimori H, Yamashita Y, Wakugawa Y, Kubo M, Tanizaki Y, Kiyohara Y, Ibayashi S, Iida M

    Cerebrovascular Disease   2008.3

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  • Renal and carotid vascular resistance assessed with Doppler sonography. Reviewed International journal

    Ohta Y, Fujii K, Ibayashi S, Matsumura K, Tsuchihashi T, Kitazono T, Ooboshi H, Kamouchi M, Hirakata H, Ogata T, Kuroda J, Iida M.

    J Clin Ultrasound   36 ( 2 )   2008.2

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  • Postischemic gene transfer of soluble Flt-1 protects against brain ischemia with marked attenuation of blood-brain barrier permeability. Reviewed International journal

    Kumai Y, Ooboshi H, Ibayashi S, Ishikawa E, Sugimori H, Kamouchu M, Kitazono T, Egashira K, Iida, M.

    J Cereb Blood Flow Metab   27 ( 6 )   2007.6

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  • Hydrogen peroxide-induced Ca2+ responses in CNS pericytes. Reviewed International journal

    Kamouchi M, Kitazono T, Ago T, Wakisaka M, Kuroda J, Nakamura K, Hagiwara N, Ooboshi H, Ibayashi S, Iida, M.

    Neurosci Lett   416 ( 1 )   2007.4

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  • Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction. Reviewed International journal

    Hata J, Matsuda K, Ninomiya T, Yonemoto K, Matsushita T, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Iida M, Kiyohara Y, Nakamura Y, Kubo M.

    Hum Mol Genet   16 ( 6 )   2007.3

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  • Role of substantia innominata in cerebral blood flow autoregulation Reviewed International journal

    Ota K, Kitazono T, Ooboshi H, Kamouchi M, Katafuchi M, Aou S, Yamashita Y, Ibayashi S, Iida M

    Brain Research   2007.3

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  • Blood pressure changes during the initial week after different subtypes of ischemic stroke. Reviewed International journal

    Toyoda K, Okada Y, Fujimoto S, Hagiwara N, Nakachi K, Kitazono T, Ibayashi S, Iida M.

    Stroke   37 ( 10 )   2006.10

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  • Valsartan improves the lower limit of cerebral autoregulation in rats. Reviewed International journal

    Takada J, Ibayashi S, Ooboshi H, Ago T, Ishikawa E, Kamouchi M, Kitazono T, Iida M.

    Hypertens Res   29 ( 8 )   2006.8

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  • Blood pressure control in hypertensive patients with a history of stroke. Reviewed International journal

    Ohta Y, Tsuchihashi T, Ibayashi S, Matsumura K, Kitazono T, Ooboshi H, Kamouchi M, Fujii K, Iida M.

    J Stroke Cerebrovasc Dis   14 ( 6 )   2005.11

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  • Selective induction of ΔFosB in the brain after transient forebrain ischemia accompanied by an increased expression of galectin-1, and the implication ofΔFosB and galectin-1 in neuroprotection and neurogenesis. Reviewed International journal

    12 ( 8 )   1078 - 1096   2005.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/sj.cdd.4401648

  • The yeast eIF4E-associated protein Eap1p attenuates GCN4 translation upon TOR-inactivation. Reviewed International journal

    Matsuo R, Kubota H, Obata T, Kito K, Ota K, Kitazono T, Ibayashi S, Sasaki T, Iida M, Ito T.

    FEBS Lett   579 ( 11 )   2433 - 2438   2005.4

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    DOI: 10.1016/j.febslet.2004.03.043

  • Postischemic gene transfer of midkine, a neurotrophic factor, protects against focal brain ischemia. Reviewed International journal

    Takada J, Ooboshi H, Ago T, Kitazono T, Yao H, Kadomatsu K, Muramatsu T, Ibayashi S, Iida M.

    Gene Ther   12 ( 6 )   487 - 493   2005.3

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    DOI: 10.1038/sj.gt.3302434

  • Postoschemic gene transfer of interleukin-10 protects against both focal and global brain ischemia. Reviewed International journal

    Ooboshi H, Ibayashi S, Shichita T, Kumai Y, Takada J, Ago T, Arakawa S, Sugimori H, Kamouchi M, Kitazono T, Iida M.

    Circulation   111 ( 7 )   2005.2

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  • Anti-monocyte chemoattractant protein-1 gene therapy protects against focal brain ischemia in hypertensive rats. Reviewed International journal

    Kumai Y, Ooboshi H, Takada J, Kamouchi M, Kitazono T, Egashira K, Ibayashi S, Iida M.

    J Cereb Blood Flow Metab   24 ( 12 )   1359 - 1368   2004.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/01.WCB.00001473534

  • Relationship between plasma glutathione levels and cardiovascular disease in a defined population: The Hisayama Study. Reviewed International journal

    Shimizu H, Kiyohara Y, Kato I, Kitazono T, Tanizaki Y, Kubo M, Ueno H, Ibayashi S, Fujishima M, Iida M.

    Stroke   35 ( 9 )   2072 - 2077   2004.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/01.STR.0000138022.86509.2d

  • Calcium influx pathways in rat CNS pericytes. Reviewed International journal

    Kamouchi M, Kitazono T, Ago T, Wakisaka M, Ooboshi H, Ibayashi S, Iida M.

    Mol Brain Res   126 ( 2 )   114 - 120   2004.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.molbrainres.2004.03.008

  • PPARgamma ligands attenuate mesangial contractile dysfunction in high glucose. Reviewed International journal

    Ueta, M., Wakisaka, M., Ago, T., Kitazono, T., Nakamura, U., Yoshinari, M., Iwase, M., Iida, M.

    Kideny International   65 ( 3 )   961 - 971   2004.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1523-1755.2004.00474.x

  • Photothrombotic middle cerebral artery occlusion and reperfusion laser system in spontaneously hypertensive rats. Reviewed International journal

    Yao H, Sugimori H, Fukuda K, Takada J, Ooboshi H, Kitazono T, Ibayashi S, Iida M.

    Stroke   34 ( 11 )   2716 - 2721   2003.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/01.STR.0000094730.38343.73

  • Adenovirus-mediated gene transfer to ischemic brain is augmented in aged rats. Reviewed International journal

    Takada J, Ooboshi H, Yao H, Kitazono T, Ibayashi S, Iida M.

    Exp Gerontol   38 ( 4 )   423 - 429   2003.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0531-5565(02)00241-3

  • Brain ischemia augments exo-focal transgene expression of adenovirus-mediated gene transfer to ependyma in hypertensive rats. Reviewed International journal

    Kumai, Y., Ooboshi, H., Kitazono, T., Takada, J., Ibayashi, S., Fujishima, M., Iida, M.

    Experimental Neurology   184 ( 2 )   904 - 911   2003.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.expneurol.2003.08.022

  • ATP-sensitive potassium channels mediate dilatation of the basilar artery in response to intracellular acidification in vivo. Reviewed International journal

    Santa, N., Kitazono, T., Ago, T., Ooboshi, H., Kamouchi, M., Wakisaka, M., Ibayashi, S., Iida, M.

    Stroke   34 ( 5 )   1276 - 1280   2003.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1161/01.STR.0000068171.01248.97

  • Role of Ca2+-activated K+ channels in the regulation of basilar arterial tone in spontaneously hypertensive rats. Reviewed International journal

    Kamouchi M, Kitazono T, Nagao T, Fujishima M, Ibayashi S.

    Clin Exp Pharmacol Physiol   29 ( 7 )   575 - 581   2002.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1046/j.1440-1681.2002.03688.x

  • Long-term effects of benidipine on cerebral vasoreactivity in hypertensive rats. Reviewed International journal

    Kitayama J, Kitazono T, Ooboshi H, Takada J, Fujishima M, Ibayashi S.

    Eur J Pharmacol   438 ( 3 )   153 - 158   2002.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0014-2999(02)01311-0

  • Chronic adminisitration of a tyrosine kinase inhibitor restores functional and morphological changes of the basilar artery during chronic hypertension. Reviewed International journal

    Kitayama, J., Kitazono, T., Ooboshi, H., Ago, T., Ohgami, T., Fujishima, M., Ibayashi, S.

    Journal of Hypertension   2002.1

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  • Role of Na+/H+ exchanger in dilator responses of rat basilar artery in vivo. Reviewed International journal

    Kitazono T, Kamouchi M, Ago T, Ooboshi H, Nakamura H, Fujishima M, Ibayashi S.

    Brain Res   906 ( 1-2 )   2001.7

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  • Bradykinin mediates the acute effect of an angiotensin-converting enzyme inhibitor on cerebral autoregulation in rats. Reviewed International journal

    Takada J, Ibayashi S, Nagao T, Ooboshi H, Kitazono T, Fujishima M.

    Stroke   32 ( 5 )   1216 - 1219   2001.5

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  • Adenovirus-mediated gene transfer to ischemic brain; ischemic flow threshold for transgene expression. Reviewed International journal

    Ooboshi H, Ibayashi S, Takada J, Yao H, Kitazono T, Fujishima M.

    Stroke   32 ( 4 )   1043 - 1047   2001.4

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  • Inhibition of Na+/H+ exchanger reduces infarct volume in thrombotic middle cerebral artery occlusion in rats. Reviewed International journal

    Kitayama, J., Kitazono, T., Yao, H., Ooboshi, H., Takaba, H., Ago, T., Fujishima, M., Ibayashi, S.

    Brain Research   922 ( 2 )   223 - 228   2001.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0006-8993(01)03175-4

  • Effect of diet on changes in small intestinal blood flow following intracolonic administration of indomethacin to rats. Reviewed International journal

    Yamamoto C, Kawakubo K, Aoyagi K, Matsumoto T, Iida M, Ibayashi S, Kitazono T, Doi K, Kanamoto K, Fujishima M.

    Digest Dis Sci   46 ( 1 )   200 - 207   2001.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1023/A:1005529016641

  • Calcium antagonist isradipine reduces metabolic alterations in acute cerebral ischemia in spontaneously hypertensive rats. Reviewed International journal

    Ibayashi S, Nagao T, Kitazono T, Ooboshi H, Kitayama J, Sadoshima S, Fujishima M.

    Neurochem Res   25 ( 3 )   349 - 355   2000.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1023/A:1007536919827

  • Effect of selective brain hypothermia on regional cerebral blood flow and tissue metabolism using brain thermoregulator in spontaneously hypertensive rats. Reviewed International journal

    Ibayashi S, Takano K, Ooboshi H, Kitazono T, Sadoshima S, Fujishima M.

    Neurochem Res   25 ( 3 )   369 - 375   2000.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1023/A:1007593004806

  • Cerebral blood flow and metabolism in patients with silent brain infarcton: occult misery perfusion in the cerebral cortex. Reviewed International journal

    Nakane H, Ibayashi S, Fujii K, Sadoshima S, Irie K, Kitazono T, Fujishima M.

    J Neurol Neurosurg Psychiatr   65 ( 3 )   317 - 321   1998.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1136/jnnp.65.3.317

  • Attenuation and recovery of brain stem autoregulation in spontaneously hypertensive rats. Reviewed International journal

    Toyoda K, Fujii K, Ibayashi S, Kitazono T, Nagao T, Takaba H, Fujishima M.

    J Cereb Blood Flow Metab   18 ( 3 )   305 - 310   1998.3

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  • Role of tyrosine kinase in serotonin-induced constriction of rat basilar artery in vivo. Reviewed International journal

    Kitazono, T., Ibayashi, S., Nagao, T., Kagiyama, T., Kitayama, J., Fujishima, M.

    Stroke   29 ( 2 )   494 - 497   1998.1

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  • Protein kinase C modulates ischemia-induced amino acids release in the striatum of hypertensive rats. Reviewed International journal

    Nakane H, Yao H, Ibayashi S, Kitazono T, Ooboshi H, Uchimura H, Fujishima M.

    Brain Res   782 ( 1-2 )   290 - 296   1998.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0006-8993(97)01331-0

  • Effects of long-acting angiotensin-converting enzyme inhibitor, imidapril, on the lower limit of cerebral blood flow autoregulation in hypertensive rats. Reviewed International journal

    Cai H, Yao H, Ibayashi S, Zhao G, Kitazono T, Nagao T, Fujishima M.

    Eur J Pharmacol   341 ( 1 )   73 - 77   1998.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0014-2999(97)01459-3

  • Role of nitric oxide in regulation of brain stem circulation during hypotension. Reviewed International journal

    Toyoda K, Fujii K, Ibayashi S, Nagao T, Kitazono T, Fujishima M.

    J Cereb Blood Flow Metab   17 ( 10 )   1089 - 1096   1997.10

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  • Role of ATP-sensitive potassium channels in brain stem circulation during hypotension. Reviewed International journal

    Toyoda K, Fujii K, Ibayashi S, Kitazono T, Nagao T, Fujishima M.

    Am J Physiol   273 ( 3 )   H1342 - H1346   1997.9

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  • An ATP-sensitive potassium channel activator reduces infarct volume in focal cerebral ischemia in rats. Reviewed International journal

    Takaba H, Nagao T, Yao H, Kitazono T, Ibayashi S, Fujishima M.

    Am J Physiol   273 ( 2 )   R583 - R586   1997.8

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  • Role of Ca2+-activated K+ channels in acetylcholine-induced dilatation of the basilar artery in vivo. Reviewed International journal

    Kitazono, T., Ibayashi, S., Nagao, T., Fujii, K., Fujishima, M.

    Britich Journal of Pharmacology   120 ( 1 )   102 - 106   1997.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/sj.bjp.0700880

  • Age-related changes in response of brain stem vessels to opening of ATP-sensitive potassium channels. Reviewed International journal

    Toyoda K, Fujii K, Takata Y, Ibayashi S, Kitazono T, Nagao T, Fujikawa M, Fujishima M.

    Stroke   28 ( 1 )   171 - 175   1997.1

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  • Altered cerebrovascular response to a potassium channel opener in hypertensive rats. Reviewed International journal

    Takaba H, Nagao T, Ibayashi S, Kitazono T, Fujii K, Fujishima M.

    Hypertension   28 ( 1 )   143 - 146   1996.7

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    Language:English   Publishing type:Research paper (scientific journal)  

  • L-Arginine restores dilator responses of the basilar artery to acetylcholine during chronic hypertension. Reviewed International journal

    Kitazono, T., Faraci, F.M., Heistad, D.D.

    Hypertension   1996.1

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  • Relaxation of the carotid artery to hypoxia is impaired in Watanabe heritable hyperlipidemic rabbits. Reviewed International journal

    Taguchi, H., Faraci, F.M., Kitazono, T., Heistad, D.D.

    Arteriosclerosis Thrombosis and Vascular Biology   1995.1

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  • Dilatation of the basilar artery in response to selective activation of endothelin B receptors in vivo. Reviewed International journal

    Kitazono, T., Heistad, D.D., Faraci, F.M.

    Journal of Pharmacology and Experimental Therapeutics   1995.1

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  • Activation of cultured bovine aortic endothelial cells by extracellular pyrimidine triphosphate. Reviewed International journal

    Kitazono T, Takeshige K, Minakami S.

    Int J Biochem   24 ( 8 )   1323 - 1327   1992.8

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  • Influence of haemorrhagic transformation on the outcome of thrombolytic therapy for patients with acute brain embolism. Reviewed International journal

    Okada Y, Sadoshima S, Saku Y, Kitazono T, Irie K, Ogasawara T, Utsunomiya H, Fujishima M.

    Neurol Res   14 ( 2 )   1992.2

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Involvement of calcium and protein kinase C in the activation of the Na+/H+ exchanger in cultured bovine aortic endotehlial cells stimulated by extracellular ATP. Reviewed International journal

    Kitazono, T., Takeshige, K., Cragoe, E.J., Jr., Minakami, S.

    Biochimica et Biophysica Acta   1013 ( 2 )   152 - 158   1989.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/0167-4889(89)90043-8

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Books

  • 脳神経疾患最新の治療 2021-2023 IV. 疾患別各論 –脳疾患– 4.脳梗塞

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    南江堂  2021.2 

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    Responsible for pages:pp96-100   Language:Japanese   Book type:Scholarly book

  • 高血圧診療ガイド2020 合併症を有する高血圧の管理:脳血管障害

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    文光堂  2020.4 

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    Responsible for pages:pp65-66   Language:Japanese   Book type:General book, introductory book for general audience

  • 高血圧診療ステップアップ-高血圧治療ガイドラインを極める- 高血圧性合併症の特徴と治療 脳血管障害.

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    診断と治療社  2019.5 

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    Responsible for pages:pp138-146   Language:Japanese   Book type:Scholarly book

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    南山堂  2019.3 

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    Responsible for pages:pp96-104   Language:Japanese   Book type:General book, introductory book for general audience

  • 症例から学ぶ 戦略的急性期脳卒中診断・治療 症例 脳梗塞 緩徐に進行するラクナ梗塞を発症した症例.

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  • 脳卒中エキスパート 抗血栓療法を究める 無症候性脳梗塞,無症候性頸部・頭蓋内脳動脈狭窄・閉塞.

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    中外医学社  2019.1 

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  • 糖尿病と循環器病 一歩進んだ糖尿病循環器学.糖尿病合併循環器病の病態と治療(4)脳卒中.

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    医薬ジャーナル社  2017.3 

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    Responsible for pages:pp152-158   Language:Japanese   Book type:Scholarly book

  • 虚血性中枢神経障害の基礎と臨床.虚血性脳卒中の予防と積極的内科治療.

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    真興交易  2016.5 

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    Responsible for pages:pp80-101   Language:Japanese   Book type:Scholarly book

  • レジデントのための脳卒中診療のコツ.慢性期再発予防のコツ.

    中村晋之, 北園 孝成( Role: Joint author)

    文光堂  2014.1 

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    Responsible for pages:pp90-98   Language:Japanese   Book type:Scholarly book

  • 脳卒中診療 こんなときどうするQ&A 第2版.脳卒中予防のための高血圧管理:至適血圧や降圧薬の種類を含む最近の考え方について教えてください.

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  • ファーマナビゲーター:脳卒中編.脳卒中急性期治療の実際:急性期の降圧治療.

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    メディカルビュー社  2006.4 

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    先端医学社  2000.9 

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    先端医学社  2000.1 

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    Responsible for pages:pp202-208   Language:Japanese   Book type:Scholarly book

  • メガトライアルから学ぶ循環器疾患の治療,EvidenceからPracticeへ.降圧薬治療と脳血管障害(一次予防)-脳卒中予防のための降圧薬治療-MRC, STONEの検討より.

    北園 孝成,井林雪郎( Role: Joint author)

    先端医学社  1999.10 

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    Responsible for pages:pp287-292   Language:Japanese   Book type:Scholarly book

  • 代謝面からみた高血圧と標的臓器障害の予防と管理.α遮断薬の脳循環への影響.

    北園 孝成,藤島正敏( Role: Joint author)

    先端医学社  1999.8 

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    Responsible for pages:pp204-211   Language:Japanese   Book type:Scholarly book

  • 循環器疾患とNO.脳循環とNO.

    北園 孝成( Role: Joint author)

    南山堂  1998.1 

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    Responsible for pages:pp141-149   Language:Japanese   Book type:Scholarly book

  • 降圧薬-上手な使用法と健康管理.脳卒中急性期・慢性期合併例.

    北園 孝成,佐渡島省三( Role: Joint author)

    メディカルコア  1997.5 

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    Responsible for pages:pp169-176   Language:Japanese   Book type:Scholarly book

▼display all

Presentations

  • 脳卒中発症後の降圧治療の現状と課題. Invited

    北園孝成、鴨打正浩

    第34回日本高血圧学会総会  2011.10 

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    Event date: 2011.10

    Presentation type:Symposium, workshop panel (public)  

    Venue:宇都宮市   Country:Japan  

  • Fukuoka Stroke Registryにみる日本人の脳卒中. Invited

    北園孝成、鴨打正浩

    第36回日本脳卒中学会総会  2011.8 

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    Event date: 2011.7 - 2011.8

    Presentation type:Symposium, workshop panel (public)  

    Venue:京都市   Country:Japan  

  • エアロゾルの脳卒中発症に及ぼす影響に関する研究-Fukuoka Stroke Registry (FSR). Invited

    北園孝成、杉森 宏、新田裕史、吾郷哲朗、桑城貴弘、鴨打正浩

    第36回日本脳卒中学会総会  2011.7 

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    Event date: 2011.7 - 2011.8

    Presentation type:Oral presentation (invited, special)  

    Venue:京都市   Country:Japan  

  • 脳梗塞のバイオマーカー探索研究(REBIOS). Invited

    北園孝成、鴨打正浩、吾郷哲朗、粟野秀人、鈴木一夫、清原 裕.

    第33回日本分子生物学会年会/第83回日本生化学会大会合同大会  2010.12 

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    Event date: 2010.12

    Presentation type:Symposium, workshop panel (public)  

    Venue:神戸市   Country:Japan  

  • 多施設共同脳卒中データベース(Fukuoka Stroke Registry)から見えてきた脳梗塞急性期の病態と予後.

    北園孝成、鴨打正浩、中根 博、尾前 豪、杉森 宏、吾郷哲朗、桑城貴弘、飯田三雄、佐渡島省三.

    第35回日本脳卒中学会総会  2010.4 

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    Event date: 2010.4

    Presentation type:Symposium, workshop panel (public)  

    Venue:盛岡   Country:Japan  

  • 多施設共同脳卒中データベース(Fukuoka Stroke Registry; FSR)からみた脳梗塞急性期症例の高血圧ならびに慢性腎臓病(CKD)の実態 Invited

    北園孝成、熊井康敬、杉森 宏、中根 博、鴨打正浩、大星博明、井林雪郎、飯田三雄、佐渡島省三

    第34回日本脳卒中学会総会  2009.3 

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    Event date: 2009.3

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 脳血管障害の分子疫学:久山町研究と福岡脳卒中データベース研究(FSR) Invited

    北園孝成、久保充明、秦 淳、清原 裕、井林雪郎、飯田三雄

    第49回日本神経学会総会  2008.5 

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    Event date: 2008.5

    Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • 脳卒中の病態と治療

    北園孝成

    第36回日本臨牀内科医学会  2023.10 

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    Event date: 2023.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:ホテル日航福岡   Country:Japan  

  • 循環器病対策推進基本計画と脳卒中医療

    北園孝成

    第31回日本心血管インターベンション治療学会学術集会  2023.8 

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    Event date: 2023.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:ヒルトン福岡シーホーク   Country:Japan  

  • PRASTRO試験

    北園孝成

    第39回日本神経治療学会学術集会  2021.10 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 脳卒中の病態と最新治療 Invited

    北園孝成

    第118回日本内科学会総会・講演会  2021.4 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

    Repository Public URL: https://hdl.handle.net/2324/7172583

  • 高齢者脳卒中の特徴と予後

    北園孝成、松尾 龍

    第62回日本老年医学会学術集会  2020.8 

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    Event date: 2021.5

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 脳梗塞の病態解明:基礎研究と臨床研究の融合を目指して

    北園孝成

    第46回日本脳卒中学会学術集会  2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 脳梗塞再発リスク因子を有する血栓性脳梗塞患者を対象としたプラスグレル第3相試験:PRASTRO-Ⅲ

    北園孝成、鴨打正浩、松丸祐司、中村正人、梅村和夫、松尾 創、小山暢之、堤 順子、木村和美

    第46回日本脳卒中学会学術集会  2021.3 

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    Event date: 2021.3

    Language:Japanese  

    Country:Japan  

  • 脳卒中と認知症の危険因子とその管理

    北園孝成、二宮利治

    第45回日本脳卒中学会学術集会  2020.8 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 高血圧ガイドライン2019(JSH2019)

    北園孝成

    第45回日本脳卒中学会学術集会  2020.8 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • コホート研究から学ぶ脳卒中の予防と管理

    北園孝成

    第34回日本女性医学会学術集会  2019.11 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 脳卒中にならないための健康管理

    北園孝成

    平成30年度第7回都民講座  2019.1 

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    Event date: 2020.7

    Language:Japanese  

    Country:Japan  

  • コホート研究からみた脳梗塞の病態と治療

    北園孝成

    第1回福岡県内科医会・福岡県臨床外科医学会合同講演会  2019.2 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 脳梗塞病型ごとのP2Y12阻害薬の有効性と安全性:PTASTRO-1サブ解析

    北園孝成、豊田一則、北川一夫、長尾毅彦、山上宏 小川彰

    第44回日本脳卒中学会学術集会  2019.3 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 脳血管障害患者における降圧目標

    北園孝成

    第8回臨床高血圧フォーラム  2019.5 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 脳梗塞の病態と治療

    北園孝成

    第19回日本NO学会学術集会  2019.6 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  • 脳卒中コホート研究からみた心房細動合併脳梗塞患者の実態

    北園孝成

    第6回日本心血管脳卒中学会学術集会  2019.6 

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    Event date: 2020.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 脳梗塞病型ごとのP2Y12阻害薬の有効性と安全性:PRASTRO-Iサブ解析

    北園孝成

    第44回日本脳卒中学会学術集  2019.3