研究者詳細 - 北園孝成

お知らせ

写真a

キタゾノ　タカナリ

北園孝成

KITAZONO TAKANARI

所属

医学研究院附属総合コホートセンター教授
医学研究院附属総合コホートセンター（併任）
九州大学病院腎・高血圧・脳血管内科（併任）
九州大学病院消化管内科（併任）
九州大学病院腎疾患治療部（併任）
医学部医学科（併任）
医学系学府医学専攻（併任）
医学系学府医科学専攻（併任）

電話番号

0926425250

プロフィール

［研究業績］久山町研究ならびに脳卒中（Fukuoka Stroke Registry; FSR）・糖尿病（Fukuoka Diabetes Registry; FDR）・腎臓病（Fukuoka Kidney disease Registry; FKR）・高血圧（Fukuoka Hypertension Cohort; FHC）・消化器疾患を対象とした疾患コホート研究を推進するとともに、動物モデルや培養細胞を用いた基礎研究を行い、生活習慣病全般の病態解明や新規治療法開発につながる基礎・臨床研究を展開している。［教育活動］学部学生の実習指導を担当。大学院生の研究指導を担当。［社会連携活動］循環器病対策基本法による基本計画に則り、福岡県循環器病推進協議会副会長として、循環器病の計画立案に主導的な役割を担っている。

ホームページ

http://www.fukuoka-stroke.net/
脳卒中コホート研究であるFukuoka Stroke Registry (FSR)のホームページ
http://www.med.kyushu-u.ac.jp/stroke/index.html
九州大学大学院医学研究院病態機能内科学（第二内科）脳循環研究室のホームページ
http://www.med.kyushu-u.ac.jp/intmed2/
九州大学大学院医学研究院病態機能内科学（第二内科）のホームページ

外部リンク

学位

医学博士

研究テーマ・研究キーワード

研究テーマ：福岡脳卒中データベース研究（The Fukuoka Stroke registry; FSR）

研究キーワード：脳卒中、コホート、疫学、登録研究

研究期間： 2007年6月
研究テーマ：脳梗塞に関する遺伝子解析研究

研究キーワード：脳梗塞、遺伝子解析、SNP

研究期間： 2005年4月
研究テーマ：脳微小循環における周皮細胞に関する分子生物学的研究

研究キーワード：脳微小循環、周皮細胞、ペリサイト

研究期間： 2004年4月
研究テーマ：脳血管反応に関する研究

研究キーワード：脳血管反応、一酸化窒素、カリウムチャンネル、高血圧

研究期間： 1991年9月

論文

Serum Ethylamine Levels as an Indicator of l-Theanine Consumption and the Risk of Type 2 Diabetes in a General Japanese Population: The Hisayama Study 査読国際誌

Ninomiya T, Kanzaki N, Hirakawa Y, Yoshinari M, Higashioka M, Honda T, Shibata M, Sakata S, Yoshida D, Teramoto T, Takemoto S, Nishimoto S, Hata J, Kitazono T.

Diabetes Care. 2019年7月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Comparison of Prasugrel and Clopidogrel in Patients With Non-Cardioembolic Ischaemic Stroke: A Phase 3, Randomised, Non-Inferiority Trial (PRASTRO-I) 査読国際誌

Ogawa A, Toyoda K, Kitagawa K, Kitazono T, Nagao T, Yamagami H, Uchiyama S, Tanahashi N, Matsumoto M, Minematsu K, Nagata I, Nishikawa M, Nanto S, Abe K, Ikeda Y; PRASTRO-I Study Group.

Lancet Neurol. 2019年3月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Nox4 Promotes Neural Stem/Precursor Cell Proliferation and Neurogenesis in the Hippocampus and Restores Memory Function Following Trimethyltin-Induced Injury 査読国際誌

Yoshikawa Y, Ago T, Kuroda J, Wakisaka Y, Tachibana M, Komori M, Shibahara T, Nakashima H, Nakashima K, Kitazono T.

Neuroscience. 2019年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Impact of Body Weight Loss From Maximum Weight on Fragility Bone Fractures in Japanese Patients With Type 2 Diabetes: The Fukuoka Diabetes Registry. 査読国際誌

Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Sumi A, Yoshinari M, Nakamura U, Kang D, Kitazono T.

Diabetes Care. 2018年5月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Insulin resistance and clinical outcomes after acute ischemic stroke. 査読国際誌

Ago T, Matsuo R, Hata J, Wakisaka Y, Kuroda J, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators.

Neurology. 90 ( 17 ) e1470 - e1477 2018年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association Between Onset-to-Door Time and Clinical Outcomes After Ischemic Stroke. 査読国際誌

Matsuo R, Yamaguchi Y, Matsushita T, Hata J, Kiyuna F, Fukuda K, Wakisaka Y, Kuroda J, Ago T, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators

Stroke 48 ( 11 ) 3049 - 3056 2017年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Day-to-Day Blood Pressure Variability and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study. 査読国際誌

Oishi E, Ohara T, Sakata S, Fukuhara M, Hata J, Yoshida D, Shibata M, Ohtsubo T, Kitazono T, Kiyohara Y, Ninomiya T

Circulation 136 ( 6 ) 516 - 525 2017年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Early Reperfusion After Brain Ischemia Has Beneficial Effects Beyond Rescuing Neurons. 査読国際誌

Tachibana M, Ago T, Wakisaka Y, Kuroda J, Shijo M, Yoshikawa Y, Komori M, Nishimura A, Makihara N, Nakamura K, Kitazono T

Stroke 48 ( 8 ) 2222 - 2230 2017年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Downregulation of Endothelial Transient Receptor Potential Vanilloid Type 4 Channel and Small-Conductance of Ca2+-Activated K+ Channels Underpins Impaired Endothelium-Dependent Hyperpolarization in Hypertension. 査読国際誌

Seki T, Goto K, Kiyohara K, Kansui Y, Murakami N, Haga Y, Ohtsubo T, Matsumura K, Kitazono T

Hypertension 69 ( 1 ) 143 - 153 2017年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Short-Term Exposure to Fine Particulate Matter and Risk of Ischemic Stroke. 査読国際誌

Matsuo R, Michikawa T, Ueda K, Ago T, Nitta H, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators

Stroke 47 ( 12 ) 3032 - 3034 2016年12月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Renal denervation has blood pressure-independent protective effects on kidney and heart in a rat model of chronic kidney disease. 査読国際誌

Eriguchi M, Tsuruya K, Haruyama N, Yamada S, Tanaka S, Suehiro T, Noguchi H, Masutani K, Torisu K, Kitazono T

Kidney Int 87 116 - 127 2015年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
High blood pressure after acute ischemic stroke is associated with poor clinical outcomes: Fukuoka Stroke Registry. 査読国際誌

Ishitsuka K, Kamouchi M, Hata J, Fukuda K, Matsuo R, Kuroda J, Ago T, Kuwashiro T, Sugimori H, Nakane H, Kitazono T; FSR Investigators

Hypertension 63 2014年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Intensity of anticoagulation and clinical outcomes in acute cardioembolic stroke: the Fukuoka Stroke Registry. 査読国際誌

Nakamura A, Ago T, Kamouchi M, Hata J, Matsuo R, Kuroda J, Kuwashiro T, Sugimori H, Kitazono T; Fukuoka Stroke Registry Investigators

Stroke 44 2013年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009). 査読国際誌

Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y

Circulation 128 2013年9月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders: results from the Hisayama Study. 査読国際誌

Nakano T, Ninomiya T, Sumiyoshi S, Onimaru M, Fujii H, Itabe H, Nakashima Y, Sueishi K, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y

Kidey Int 84 2013年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Extracellular acidification activates cAMP responsive element binding protein via Na+/H+ exchanger isoform 1-mediated Ca2+ oscillation in central nervous system pericytes. 査読国際誌

Nakamura K, Kamouchi M, Arimura K, Nishimura A, Kuroda J, Ishitsuka K, Tokami H, Sugimori H, Ago T, Kitazono T

Arterioscler Thromb Vasc Biol 32 2012年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Proteinuria and clinical outcomes after ischemic stroke. 査読国際誌

Kumai Y, Kamouchi M, Hata J, Ago T, Kitayama J, Nakane H, Sugimori H, Kitazono T, for the FSR Investigators

Neurology 78 2012年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain. 査読国際誌

Shichita T, Hasegawa E, Kimura A, Morita R, Sakaguchi R, Takada I, Sekiya T, Ooboshi H, Kitazono T, Yanagawa T, Ishii T, Takahashi H, Mori S, Nishibori M, Kuroda K, Akira S, Miyake K, Yoshimura A

Nat Med 18 2012年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）
PDGF receptor β signaling in pericytes following ischemic brain injury. 査読国際誌

9 2012年2月

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記述言語：英語掲載種別：研究論文（学術雑誌）
The antioxidant tempol ameliorates arterial medial calcification in uremic rats: important role of oxidative stress in the pathogenisis of vascular calcification in chronic kidney disease. 査読国際誌

Yamada S, Taniguchi M, Tokumoto M, Toyonaga J, Fujisaki K, Suehiro T, Noguchi H, Iida M, Tsuruya K, Kitazono T.

J Bone Miner Res 27 ( 2 ) 2012年2月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Prestroke glycemic control is associated with the functional outcome in acute ischemic stroke: the Fukuoka Stroke Registry. 査読国際誌

Kamouchi M, Matsuki T, Hata J, Kuwashiro T, Ago T, Sambongi Y, Fukushima Y, Sugimori H, Kitazono T; for the FSR investigators.

Stroke 42 2011年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke. 査読国際誌

Matsushita T, Ashikawa K, Yonemoto K, Hirakawa Y, Hata J, Amitani H, Doi Y, Ninomiya T, Kitaozono T, Ibayashi S, Iida M, Nakamura Y, Kiyohara Y, Kubo M.

Hum Mol Genet 19 ( 6 ) 2010年3月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Role of NHE1 in calcium signaling and cell proliferation in human CNS pericytes 査読国際誌

Nakamura K, Kamouchi M, Kitazono T, Kuroda J, Matsuo R, Hagiwara N, Ishikawa E, Ooboshi H, Ibayashi S, Iida M

American Journal of Physiology 2008年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）
NAD(P)H oxidase p22phox C242T polymorphism and ischemic stroke in Japan: the Fukuoka Stroke Registry and the Hisayama Study 査読国際誌

Kuroda J, Kitazono T, Ago T, Ninomiya T, Ooboshi H, Kamouchi M, Kumai Y, Hagiwara N, Yoshimura S, Tamaki K, Kusuda K, Fujii K, Nagao T, Okada Y, Toyoda K, Nakane H, Sugimori H, Yamashita Y, Wakugawa Y, Asano K, Tanizaki Y, Kiyohada Y, Ibayashi S, Iida M

European Journal of Neurology 2007年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）
A nonsynonymous SNP IN PRKCH (protein kinase Cη) increases the risk of cerebral infarction. 査読国際誌

39 ( 2 ) 2007年2月

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記述言語：英語掲載種別：研究論文（学術雑誌）
NAD(P)H oxidases in rat basilar arterial endothelial cells. 査読国際誌

Ago T, Kitazono T, Kuroda J, Kumai Y, Kamouchi M, Ooboshi H, Wakisaka M, Kawahara T, Rokutan K, Ibayashi S, Iida M.

Stroke 36 ( 5 ) 1040 - 1046 2005年5月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1161/01.STR.0000163111.05825.0b
NOX4 as the major catalytic component of an endothelial NAD(P)H oxidase. 査読国際誌

Ago, T., Kitazono, T., Ooboshi, H., Matsuo, R., Takada, J., Wakisaka, M., Ibayashi, S., Iida, M

Circuration 109 ( 2 ) 227 - 233 2004年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1161/01.CIR.0000105680.92873.70
Increased activity of calcium channels and Rho-associated kinase in the basilar artery during chronic hypertension in vivo. 査読国際誌

Kitazono, T., Ago, T., Kamouchi, M., Santa, N., Ooboshi, H., Fujishima, M., Ibayashi, S.

Journal of Hypertension 20 ( 5 ) 879 - 884 2002年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1097/00004872-200205000-00022
Sodium-coupled glucose transporter as a functional glucose sensor of retinal microvascular circulation. 査読国際誌

Wakisaka, M., Kitazono, T., Kato, M., Nakamura, U., Yoshioka, M., Uchizono, Y., Yoshinari, M.

Circulation Research 88 ( 11 ) 1183 - 1188 2001年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1161/hh1101.091265
Role of phosphatidylinositol 3-kinase in acetylcholine-induced dilatation of rat basilar artery in vivo. 査読国際誌

Kitayama, J., Kitazono, T., Ibayashi, S., Nagao, T., Wakisaka, M., Watanabe, Y., Fujishima, M.

Stroke 31 ( 10 ) 2487 - 2492 2000年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Role of tyrosine kinase in dilator responses of the basilar artery in vivo. 査読国際誌

Kitazono, T., Ibayashi, S., Nagao, T., Fujii, K., Kagiyama, T., Fujishima, M.

Hypertension 31 ( 3 ) 861 - 865 1998年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Dilatation of cerebral arterioles in response to activation of adenylate cyclase is dependent on activation of Ca2+-dependent K+ channels. 査読国際誌

Taguchi, H., Heistad, D.D., Kitazono, T., Faraci, F.M.

Circulation Research 1995年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Evidence that angiotensin II is present in human monocytes. 査読国際誌

Kitazono, T., Padgett, R.C., Armstrong, M.L., Tompkins, P.K., Heistad, D.D.

Circulation 1995年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Enhanced responses of the basilar artery to activation of endothelin B receptors in stroke-prone spontaneously hypertensive rats. 査読国際誌

Kitazono, T., Heistad, D.D., Faraci, F.M.

Hypertension 1995年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Relaxation of the aorta during hypertension is impaired in chronically hypertensive rats. 査読国際誌

Taguchi, H., Faraci, F.M., Kitazono, T., Heistad, D.D.

Hypertension 1995年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
ATP-sensitive K+ channels mediate dilatation of cerebral arterioles during hypoxia. 査読国際誌

Taguchi H, Heistad DD, Kitazono T, Faraci FM

Circulation Research 1994年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
ATP-sensitive potassium channels in the basilar artery during chronic hypertension. 査読国際誌

Kitazono, T., Heistad, D.D., Faraci, F.M.

Hypertension 1993年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Effect of norepinephrine on rat basilar artery in vivo. 査読国際誌

Kitazono, T., Faraci, F.M., Heistad, D.D.

American Journal of Physiology 1993年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Role of ATP-sensitive K+ channels in CGRP-induced dilatation of the basilar artery in vivo. 査読国際誌

Kitazono, T., Heistad, D.D., Faraci, F.M.

American Journal of Physiology 1993年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Intracellular pH changes of cultured bovine aortic endothelial cells in response to ATP addition. 査読国際誌

Kitazono, T., Takeshige, K., Cragoe, E.J., Jr., Minakami, S.

Biochemical and Biophysical Research Communication 152 ( 3 ) 1304 - 1309 1988年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/S0006-291X(88)80427-3
Blood Hemoglobin Concentrations and the Incidence of Lower Extremity Peripheral Arterial Disease in Patients Undergoing Hemodialysis: 10-Year Outcomes of the Q-Cohort Study

Kohara C., Yamada S., Tanaka S., Hiyamuta H., Kitamura H., Arase H., Shimamoto S., Taniguchi M., Tsuruya K., Kitazono T., Nakano T.

Journal of the American Heart Association 13 ( 15 ) e033853 2024年8月

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記述言語：英語出版者・発行元：Journal of the American Heart Association

BACKGROUND: Lower extremity peripheral arterial disease is a potentially lethal cardiovascular complication in patients undergoing hemodialysis. Anemia is a risk factor for cardiovascular disease among the hemodialysis population. However, whether blood hemoglobin concentration is associated with the risk of peripheral arterial disease progression in this population remains undetermined. METHODS AND RESULTS: This is an extension of a 4-year multicenter, prospective, observational cohort study to 10 years. A total of 3504 Japanese patients undergoing maintenance hemodialysis were recruited between 2006 and 2007. The primary exposure was blood hemoglobin concentration at baseline. The main outcome was the first-ever incidence of major adverse limb events (MALE), composed of endovascular treatment, bypass surgery, and amputation. Multivariable-adjusted Cox proportional hazards model, Fine–Gray subdistribution hazards model, restricted cubic spline analysis, and restricted mean survival time analysis were used to determine the association of blood hemoglobin concentration with the incidence of MALE. During a median follow-up of 8.0 years, 257 patients experienced MALE. A Cox proportional hazards model showed that the risk of MALE in patients with blood hemoglobin concentrations <10.0 g/dL was significantly higher than in patients with concentrations of 11.0 to 11.9 g/dL, even after adjusting for confounding factors. In contrast, elevated hemoglobin concentration (≥12.0 g/ dL) was not significantly associated with increased risk of MALE. Similar associations were observed when the Fine–Gray subdistribution regression model was used by setting all-cause mortality as the competing risk. CONCLUSIONS: A low blood hemoglobin concentration is an independent risk factor for peripheral arterial disease progression in patients undergoing maintenance hemodialysis.

DOI： 10.1161/JAHA.123.033853

Scopus

PubMed
Association between Vascular Calcification and Intraplaque Hemorrhage in Coronary Atherosclerosis from Autopsy: The Hisayama Study

Nakano, T; Kitamura, H; Hata, J; Maki, K; Oda, Y; Kitazono, T; Ninomiya, T

Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 31 ( 8 ) 1225 - 1237 2024年8月（ ISSN:13403478 eISSN:18803873 ）

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記述言語：英語出版者・発行元：一般社団法人日本動脈硬化学会

Aims: Vascular calcification is observed in advanced atherosclerotic lesions. Vascular calcification is considered to increase the risk of intraplaque hemorrhage and subsequent plaque destabilization; however, there is limited pathohistoological evidence of the association between vascular calcification and intraplaque hemorrhage. The aim of this study was to investigate the association between vascular calcification and intraplaque hemorrhage in the coronary arteries. Methods: We examined 374 coronary arteries obtained from the autopsy samples of 126 deceased individuals. The vascular calcification levels of each artery were categorized into no calcification and quintiles of calcification area size among the arteries with calcification. Macrophage infiltration and neovascularization were also evaluated. The association of the calcification area, macrophage area, or number of vessels with the presence of intraplaque hemorrhage in the coronary arteries was estimated using a logistic regression analysis.Results: Calcification lesions were observed in 149 coronary arteries. Arteries in the fourth quintile of calcification area size had a significantly greater likelihood of intraplaque hemorrhage than the arteries without calcification, after adjusting for confounders: odds ratio 13.13 (95% confidence interval: 2.97–58.16). After evaluating the influence of macrophage infiltration, the highest odds ratio of intraplaque hemorrhage was associated with the combination of large macrophage area and moderately sized calicification areas. The odds ratio of intraplaque hemorrhage additively increased with the combination of calcification and the number of vessels. Conclusions: The present findings suggest that vascular calcification is significantly associated with intraplaque hemorrhage. The association between vascular calcification and intraplaque hemorrhage may decrease above a certain size of the calcification area.

DOI： 10.5551/jat.64394

Web of Science

Scopus

PubMed

CiNii Research
Association between Hemoglobin A1c and Renal Arteriolar Sclerosis in Subjects Presenting without any Apparent Kidney Dysfunction

Matsukuma, Y; Tsuchimoto, A; Masutani, K; Ueki, K; Tanaka, S; Haruyama, N; Okabe, Y; Nakamura, M; Kitazono, T; Nakano, T

Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 31 ( 8 ) 1215 - 1224 2024年8月（ ISSN:13403478 eISSN:18803873 ）

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記述言語：英語出版者・発行元：一般社団法人日本動脈硬化学会

Aims: Diabetic kidney disease is a major vascular complication in patients with diabetes mellitus (DM). However, the association between the hemoglobin (Hb)A1c levels, notably the prediabetic levels, and renal pathological changes remains unclear. We investigated the association between the HbA1c levels and renal arteriolar lesions in subjects without any apparent kidney dysfunction using a living kidney donor cohort. Methods: Between January 2006 and May 2016, 393 living kidney donors underwent a "zero-time" biopsy at Kyushu University Hospital. The patients were divided into four groups (HbA1c levels ＜5.6%, 5.6%–5.7%, 5.8%–6.4%, and ≥ 6.5%, or diagnosed with DM [DM group]). Renal arteriolar hyalinization and wall thickening were assessed using semi-quantitative grading. We then investigated the association between the HbA1c levels and renal pathological changes. Results: 158 (40.2%) patients had arteriolar hyalinization and 148 (37.6%) showed wall thickening. A significant correlation was observed between the HbA1c levels and wall thickening (p for trend ＜0.001). An elevated HbA1c level was significantly associated with wall thickening according to a multivariable logistic analysis in subjects with HbA1c levels of 5.6%–5.7% and 5.8%–6.4%, and the DM group, compared with those with HbA1c levels of ＜5.6% (odds ratio [OR], 1.91; 95% confidence interval [CI]: [1.03–3.54] for 5.6%–5.7%, OR, 1.96; 95% CI: [1.09–3.53] for 5.8%–6.4%, and OR, 2.86; 95% CI: [0.91–9.01] for the DM group), whereas arteriolar hyalinization did not increase within the nondiabetic HbA1c levels. Conclusions: Elevated high-normal HbA1c levels are considered to be independent risk factors for arteriolar wall thickening. Subclinical renal arteriolar sclerosis may develop in patients with prediabetic HbA1c levels.

DOI： 10.5551/jat.64236

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CiNii Research
Arginase 2 attenuates ulcerative colitis by antioxidant effects of spermidine

Imazu, N; Torisu, T; Yokote, A; Umeno, J; Kawasaki, K; Fujioka, S; Matsuno, Y; Nagasue, T; Kawatoko, S; Moriyama, T; Nitahata, T; Uchida, Y; Aihara, S; Taniguchi, Y; Oda, Y; Kitazono, T

JOURNAL OF GASTROENTEROLOGY 59 ( 8 ) 682 - 698 2024年8月（ ISSN:0944-1174 eISSN:1435-5922 ）

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記述言語：英語出版者・発行元：Journal of Gastroenterology

Background: Spermidine suppress oxidative stress and is involved in various disease pathogenesis including ulcerative colitis (UC). Arginase 2 (ARG2) plays a central role in the synthesis of spermidine. This study aimed to clarify the effect of endogenously produced spermidine on colitis. Methods: The physiological role of ARG2 and spermidine was investigated using Arg2-deficient mice with reduced spermidine. Immunohistochemical staining of the rectum was used to analyze ARG2 expression and spermidine levels in healthy controls and UC patients. Results: In mice with dextran sulfate sodium-induced colitis, ARG2 and spermidine levels were increased in the rectal epithelium. Spermidine protects colonic epithelial cells from oxidative stress and Arg2 knockdown cells reduced antioxidant activity. Organoids cultured from the small intestine and colon of Arg2-deficient mice both were more susceptible to oxidative stress. Colitis was exacerbated in Arg2-deficient mice compared to wild-type mice. Supplementation with spermidine result in comparable severity of colitis in both wild-type and Arg2-deficient mice. In the active phase of UC, rectal ARG2 expression and spermidine accumulation were increased compared to remission. ARG2 and spermidine levels were similar in healthy controls and UC remission patients. Conclusions: ARG2 produces spermidine endogenously in the intestinal epithelium and has a palliative effect on ulcerative colitis. ARG2 and spermidine are potential novel therapeutic targets for UC.

DOI： 10.1007/s00535-024-02104-z

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Association between glycated albumin and sudden death in patients undergoing hemodialysis

Kaizu, Y; Nagata, M; Kaizu, S; Qie, YL; Kaizu, K; Tanaka, S; Nakano, T; Kitazono, T

CLINICAL AND EXPERIMENTAL NEPHROLOGY 28 ( 7 ) 656 - 663 2024年7月（ ISSN:1342-1751 eISSN:1437-7799 ）

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記述言語：英語出版者・発行元：Clinical and Experimental Nephrology

Background: The frequency of sudden death and its risk factors in patients undergoing hemodialysis are unknown. This study was performed to examine the association between glycated albumin (GA) and sudden death in Japanese patients undergoing hemodialysis. Methods: In total, 260 patients undergoing hemodialysis aged ≥18 years were retrospectively followed for a mean of 4.6 years. The patients’ serum GA levels were divided into tertiles, and the patients’ sex, age, albumin level, C-reactive protein (CRP) level, and cardiothoracic ratio (CTR) were selected as adjustment factors. A logistic regression model was used to calculate the odds ratio (OR) for the occurrence of sudden death by GA level. Results: Ninety-one patients died during follow-up. Of the 91 deaths, 23 (25.2%) were defined as sudden deaths. Compared with non-sudden death cases, sudden death cases were significantly younger (p = 0.002) and had a higher proportion of men (p = 0.03), a higher proportion of diabetes (p = 0.008), and higher GA levels (p = 0.023). Compared with patients with the lowest GA levels (<15.2%), those with the highest GA levels (≥18.5%) had a sex- and age-adjusted OR for sudden death of 5.40 [95% confidence interval (CI): 1.35–21.85]. After adjusting for the albumin level, CRP level, and CTR in addition to sex and age, the OR for sudden death of patients with the highest GA levels increased to 6.80 (95%CI: 1.64–28.08); the relationship did not change. Conclusion: Serum GA levels were significantly associated with sudden death in patients undergoing hemodialysis.

DOI： 10.1007/s10157-024-02475-w

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Association between retinopathy and risk of dementia in a general Japanese population: the Hisayama Study

Nakamura, S; Ueda, E; Ohara, T; Hata, J; Honda, T; Fujiwara, K; Furuta, Y; Shibata, M; Hashimoto, S; Nakazawa, T; Nakao, T; Kitazono, T; Sonoda, KH; Ninomiya, T

SCIENTIFIC REPORTS 14 ( 1 ) 12017 2024年5月（ ISSN:2045-2322 ）

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記述言語：英語出版者・発行元：Scientific Reports

We investigated the association of retinopathy with the risk of dementia in a general older Japanese population. A total of 1709 population-based residents aged 60 years or older without dementia were followed prospectively for 10 years (2007–2017). They underwent color fundus photography in 2007. Retinopathy was graded according to the Modified Airlie House Classification. Main outcome was the Incidence of dementia. A Cox proportional hazards model was used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) for the risk of dementia by the presence of retinopathy. During the follow-up period, 374 participants developed all-cause dementia. The cumulative incidence of dementia was significantly higher in those with retinopathy than those without (p < 0.05). Individuals with retinopathy had significantly higher risk of developing dementia than those without after adjustment for potential confounding factors (HR 1.64, 95% CI 1.19–2.25). Regarding the components of retinopathy, the presence of microaneurysms was significantly associated with a higher multivariable-adjusted HR for incident dementia (HR 1.94, 95% CI 1.37–2.74). Our findings suggest that, in addition to systemic risk factors, retinal microvascular signs from fundus photography provide valuable information for estimating the risk of developing dementia.

DOI： 10.1038/s41598-024-62688-7

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Association Between Serum NT-proBNP and Gray Matter Atrophy Patterns in an Older Japanese Population: The Hisayama Study

Hirabayashi, N; Hata, J; Furuta, Y; Nakazawa, T; Ohara, T; Shibata, M; Yamashita, F; Kitazono, T; Sudo, N; Ninomiya, T

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 79 ( 5 ) 2024年5月（ ISSN:1079-5006 eISSN:1758-535X ）

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記述言語：英語出版者・発行元：Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Several population-based studies have reported that higher serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels are associated with brain morphological changes. However, no population-based studies have examined the relationship between serum NT-proBNP and various regional brain volumes in detail. We here analyzed the brain MRI data of 1 201 community-dwelling Japanese aged =65 years. Regional gray matter volumes (GMV) and intracranial volume (ICV) were estimated by applying voxel-based morphometry (VBM) methods. The associations of serum NT-proBNP with regional GMV/ICV were examined by analysis of covariance. The regional gray matter atrophy patterns associated with elevated serum NT-proBNP levels were investigated using VBM without a priori regions of interest. The multivariable-adjusted means of the frontal, temporal, hippocampal, parahippocampal, and entorhinal GMV/ICV decreased significantly with elevated serum NT-proBNP levels (all p for trend and q values of false discovery rate correction < .05). In VBM, elevated serum NT-proBNP levels were correlated with atrophy of the bilateral hippocampi, bilateral amygdalas, bilateral parahippocampal gyri, bilateral entorhinal areas, bilateral fusiform gyri, left middle temporal gyrus, left inferior temporal gyrus, right central operculum, right posterior orbital gyrus, bilateral middle frontal gyri, anterior cingulate gyrus and bilateral medial frontal cortices. In a sensitivity analysis excluding 254 participants with mild cognitive impairment or dementia, serum NT-proBNP levels were correlated with atrophy of the bilateral hippocampi, bilateral amygdalas, bilateral parahippocampal gyri, bilateral fusiform gyri, and left middle frontal gyrus. Our data suggest that elevated serum NT-proBNP levels are associated with gray matter atrophy in brain regions that play an important role in cognitive function.

DOI： 10.1093/gerona/glae075

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A simple score for malnutrition-inflammation complex syndrome (MICS) is associated with the risk of mortality in Japanese patients undergoing maintenance hemodialysis

Yamada, S; Arase, H; Taniguchi, M; Kitazono, T; Nakano, T

THERAPEUTIC APHERESIS AND DIALYSIS 28 ( 2 ) 206 - 217 2024年4月（ ISSN:1744-9979 eISSN:1744-9987 ）

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記述言語：英語出版者・発行元：Therapeutic Apheresis and Dialysis

Introduction: Malnutrition–inflammation complex syndrome (MICS) is highly prevalent in patients undergoing hemodialysis. We determined the prognostic value of the Simple MICS score, calculated using a combination of age, body mass index, and serum concentrations of albumin, creatinine, and C-reactive protein. Methods: We retrospectively recruited 218 Japanese patients undergoing maintenance hemodialysis. The primary outcome was all-cause mortality, and the main exposure was the Simple MICS score. Cox proportional hazard regression analysis and logistic regression analysis were used to characterize the relationship between the Simple MICS score and mortality. Results: During a median 4.4-year follow-up period, 56 patients died. Multivariable-adjusted models showed that a higher Simple MICS score was associated with higher risks of mortality. The predictability for all-cause mortality of the Simple MICS score was significantly better than conventional nutrition-related indices. Conclusion: The Simple MICS score can be used to stratify mortality risk in patients undergoing maintenance hemodialysis.

DOI： 10.1111/1744-9987.14085

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Impact of Electrocardiographic Parameters on Sudden Death in Patients Receiving Maintenance Hemodialysis: Ten-Year Outcomes of the Q-Cohort Study 査読国際誌

Hiyamuta H, Yamada S, Nakano T, Taniguchi M, Masutani K, Tsuruya K, Kitazono T

J Atheroscler Thromb 2024年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
History of fragility fracture is associated with cardiovascular mortality in hemodialysis patients: the Q-Cohort study 査読国際誌

Haruyama N, Nakayama M, Yamada S, Tanaka S, Hiyamuta H, Taniguchi M, Tokumoto M, Tsuruya K, Kitazono T, Nakano T

J Bone Miner Metab 2024年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Longitudinal association of sedentary time with diabetes mellitus and markers of glucose metabolism in middle-aged and older adults: The Hisayama Study 査読国際誌

Tsuda S, Honda T, Higashioka M, Hata J, Nakano T, Kitazono T, Ninomiya T

J Diabetes Investig 2024年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association between abdominal adiposity and clinical outcomes in patients with acute ischemic stroke

Wakisaka, K; Matsuo, R; Irie, F; Wakisaka, Y; Ago, T; Kamouchi, M; Kitazono, T

PLOS ONE 19 ( 1 ) e0296833 2024年1月（ ISSN:1932-6203 ）

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記述言語：英語出版者・発行元：PLoS ONE

Background It is unclear whether abdominal adiposity has an additional effect on post-stroke outcomes. This study aimed to determine whether waist circumference (WC) is independently associated with clinical outcomes after acute ischemic stroke. Methods We enrolled patients with acute ischemic stroke from a multicenter hospital-based stroke registry in Fukuoka, Japan. We measured WC on admission and categorized patients into four groups (Q1–Q4) according to the quartiles in females and males. The clinical outcomes were poor functional outcome (modified Rankin scale score 2–6) and death from any cause. Logistic regression analysis was performed to estimate the odds ratio and 95% confidence interval of the outcomes of interest after adjusting for potential confounding factors, including body mass index (BMI). Results A total of 11,989 patients (70.3±12.2 years, females: 36.1%) were included in the analysis. The risk of poor functional outcome significantly decreased for Q2–Q4 (vs. Q1) at discharge and Q2–Q3 (vs. Q1) at 3 months, even after adjusting for potential confounders, including BMI. In contrast, adjustment of BMI eliminated the significant association between WC and all-cause death at discharge and 3 months. The association between high WC and favorable functional outcome was not affected by fasting insulin levels or homeostatic model assessment for insulin resistance and was only found in patients without diabetes (P = 0.02 for heterogeneity). Conclusions These findings suggest that abdominal adiposity has an additional impact on post-stroke functional outcome, independent of body weight and insulin action.

DOI： 10.1371/journal.pone.0296833

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Body temperature in the acute phase and clinical outcomes after acute ischemic stroke

Mezuki, S; Matsuo, R; Irie, F; Shono, Y; Kuwashiro, T; Sugimori, H; Wakisaka, Y; Ago, T; Kamouchi, M; Kitazono, T

PLOS ONE 19 ( 1 ) e0296639 2024年1月（ ISSN:1932-6203 ）

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記述言語：英語出版者・発行元：PLoS ONE

Background This study aimed to examine whether post-stroke early body temperature is associated with neurological damage in the acute phase and functional outcomes at three months. Methods We included 7,177 patients with acute ischemic stroke within 24 h of onset. Axillary temperature was measured daily in the morning for seven days. Mean body temperature was grouped into five quintiles (Q1: 35.1–36.5◦C, Q2: 36.5–36.7◦C, Q3: 36.7–36.8◦C, Q4: 36.8–37.1◦C, and Q5: 37.1–39.1◦C). Clinical outcomes included neurological improvement during hospitalization and poor functional outcome (modified Rankin scale score, 3–6) at three months. A logistic regression analysis was performed to evaluate the association between body temperature and clinical outcomes. Results The patient’s mean (SD) age was 70.6 (12.3) years, and 35.7% of patients were women. Mean body temperature was significantly associated with less neurological improvement from Q2 (odds ratios [95% confidence interval], 0.77 [0.65–0.99] vs. Q1) to Q5 (0.33 [0.28–0.40], P for trend <0.001) even after adjusting for potential confounders, including baseline neurological severity, C-reactive protein levels, and post-stroke acute infections. The multivariable-adjusted risk of poor functional outcome linearly increased from Q2 (1.36 [1.03–1.79]) to Q5 (6.44 [5.19–8.96], P for trend <0.001). These associations were maintained even in the analyses excluding patients with acute infectious diseases. Multivariable-adjusted risk of poor functional outcome was higher in patients with early body temperature elevation on days 1–3 and with longer duration with body temperature >37.0◦C. Conclusions Post-stroke early high body temperature is independently associated with unfavorable outcomes following acute ischemic stroke.

DOI： 10.1371/journal.pone.0296639

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Serum Lipopolysaccharide-binding Protein Levels and the Incidence of Metabolic Syndrome in a General Japanese Population: the Hisayama Study 査読国際誌

Tomooka S, Oishi E, Asada M, Sakata S, Hata J, Chen S, Honda T, Suzuki K, Watanabe H, Murayama N, Wada N, Kitazono T, Ninomiya T

J Epidemiol 2024年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Reply to "Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis" 査読国際誌

Yokote A, Imazu N, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Moriyama T, Miyawaki K, Akashi K, Kitazono T, Torisu T

J Gastroenterol 2024年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Ustekinumab Decreases Circulating Th17 Cells in Ulcerative Colitis 査読国際誌

Imazu N, Torisu T, Ihara Y, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Moriyama T, Kitazono T

Intern Med 2024年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Associations between the Serum Triglyceride Level and Kidney Outcome in Patients with Chronic Kidney Disease: The Fukuoka Kidney disease Registry Study

Seki, M; Nakano, T; Tanaka, S; Kitamura, H; Hiyamuta, H; Ninomiya, T; Tsuruya, K; Kitazono, T

Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ advpub ( 0 ) 2024年（ ISSN:13403478 eISSN:18803873 ）

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記述言語：英語出版者・発行元：一般社団法人日本動脈硬化学会

DOI： 10.5551/jat.64625

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Association of sarcopenia with regional brain atrophy and white matter lesions in a general older population: the Hisayama Study

Tajimi T., Hirabayashi N., Furuta Y., Nakazawa T., Honda T., Hata J., Ohara T., Shibata M., Kitazono T., Nakashima Y., Ninomiya T.

GeroScience 2024年（ ISSN:25092715 ）

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記述言語：英語出版者・発行元：GeroScience

Sarcopenia has been reported to be associated with cognitive decline and the risk of dementia. However, few studies have addressed the association between sarcopenia and brain morphological changes in the general population. A total of 1373 community-dwelling participants aged ≥ 65 years underwent brain MRI. Sarcopenia was defined based on the Asian Working Group for Sarcopenia's criteria. The pattern of regional gray matter volume loss associated with sarcopenia were assessed using a voxel-based morphometry (VBM) analysis. Regional brain volumes, intracranial volumes (ICV), and white matter lesions volumes (WMLV) were also measured using FreeSurfer. An analysis of covariance was used to examine the associations of sarcopenia with regional brain volumes in proportion to ICV. Of the participants, 112 had sarcopenia. The participants with sarcopenia had significantly lower total brain volume/ICV and total gray matter volume/ICV and higher WMLV/ICV than those without sarcopenia after adjusting for confounders. In VBM, sarcopenia was associated with lower gray matter volume in the frontal lobe, insula, cingulate gyrus, hippocampus, amygdala, and basal ganglia. Using FreeSurfer, we confirmed that the participants with sarcopenia had significantly lower frontal, insular, cingulate, and hippocampal volumes than those without sarcopenia. The current study showed that participants with sarcopenia had significantly lower volume in the frontal lobe, insula, cingulate, and hippocampus and higher WMLV than participants without sarcopenia. As these brain regions are likely to play an important role in cognitive function, these changes may suggest a shared underlying mechanism for the progression of sarcopenia and cognitive decline.

DOI： 10.1007/s11357-024-01289-8

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Clinical Features of Gastroduodenal Ulcers in Kidney Transplant Patients 査読国際誌

Kondo M, Torisu T, Ihara Y, Kawasaki K, Umeno J, Kawatoko S, Tsuchimoto A, Nakano T, Okabe Y, Kitazono T

Intern Med 2023年12月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Risks of dementia in a general Japanese older population with preserved ratio impaired spirometry: The Hisayama Study 査読国際誌

Kawatoko K, Washio Y, Ohara T, Fukuyama S, Honda T, Hata J, Nakazawa T, Kan-O K, Inoue H, Matsumoto K, Nakao T, Kitazono T, Okamoto I, Ninomiya T

J Epidemiol 2023年12月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
More rapid progression of brain atrophy in patients on peritoneal dialysis compared with hemodialysis: The VCOHP Study 査読国際誌

Tsuruya K, Yoshida H, Yamada S, Haruyama N, Tanaka S, Tsuchimoto A, Eriguchi M, Fujisaki K, Torisu K, Nakano T, Masutani K, Kitazono T

Hypertens Res 2023年12月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
FLAIR hyperintense cortical lesions in anti-myelin oligodendrocyte glycoprotein antibody-associated encephalitis with seizure following SARS-CoV-2 mRNA vaccination 査読国際誌

Yoshino F, Ozaki Y, Shibahara T, Matsuoka M, Tachibana M, Ago T, Kitazono T, Kuroda J, Nakane H

eNeurologicalSci 2023年12月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Prevalence of hyponatremia and associated factors in patients with chronic kidney disease: the Fukuoka Kidney Disease Registry (FKR) study 査読国際誌

Inoue M, Nakai K, Tanaka S, Mitsuiki K, Tokumoto M, Tsuruya K, Kitazono T, Nakano T

Clin Exp Nephrol 2023年12月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Development and Validation of a Risk Prediction Model for Atherosclerotic Cardiovascular Disease in Japanese Adults: The Hisayama Study 査読国際誌

Honda T, Chen S, Hata J, Yoshida D, Hirakawa Y, Furuta Y, Shibata M, Sakata S, Kitazono T, Ninomiya T

J Atheroscler Thromb 2023年12月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Disease Flares Following COVID-19 Vaccination in Patients with Inflammatory Bowel Disease 査読国際誌

Yoshida Y, Fujioka S, Moriyama T, Umeno J, Kawasaki K, Fuyuno Y, Matsuno Y, Ihara Y, Torisu T, Kitazono T

Intern Med 2023年12月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Effectiveness and safety of reduced-dose rivaroxaban for elderly patients with non-valvular atrial fibrillation: A subanalysis of the EXPAND study 査読国際誌

Shimizu W, Uchiyama S, Atarashi H, Inoue H, Kitazono T, Yamashita T, Ikeda T, Kamouchi M, Kaikita K, Fukuda K, Origasa H, Shimokawa H

Int J Cardiol 2023年11月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Cumulative smoking dose is associated with subclinical renal injury: a pathological study in individuals without chronic kidney disease 査読国際誌

Ataka E, Matsukuma Y, Ueki K, Tsuchimoto A, Okabe Y, Masutani K, Nakamura M, Nakano T, Kitazono T

Nephrol Dial Transplant 2023年11月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Angiotensin II receptor blockers and bone fracture in chronic kidney disease patients: the Fukuoka kidney disease Registry Study 査読国際誌

Shukuri T, Nakai K, Tanaka S, Yamada S, Tokumoto M, Tsuruya K, Nakano T, Kitazono T

Clin Exp Nephrol 2023年11月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Angiotensin II receptor blockers and bone fracture in chronic kidney disease patients: the Fukuoka kidney disease Registry Study

Shukuri, T; Nakai, K; Tanaka, S; Yamada, S; Tokumoto, M; Tsuruya, K; Nakano, T; Kitazono, T

CLINICAL AND EXPERIMENTAL NEPHROLOGY 27 ( 11 ) 919 - 927 2023年11月（ ISSN:1342-1751 eISSN:1437-7799 ）

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記述言語：英語出版者・発行元：Clinical and Experimental Nephrology

Background: Angiotensin II receptor blockers (ARBs) reportedly reduce the risk of developing bone fractures; however, this association remains unclear among patients with chronic kidney disease (CKD). Methods: This was a cross-sectional study of 3380 CKD patients enrolled in the Fukuoka Kidney disease Registry Study, a multicenter prospective observational cohort study of non-dialysis-dependent CKD patients. The patients were divided into two groups, those taking ARBs and those who were not. Logistic regression models were used to examine the association between ARBs and bone fracture. Results: Approximately 67.0% of the participants were on ARBs, and 6.3% had a history of bone fracture. The history of bone fracture was significantly lower in patients with prescribed ARB and remained significant even after multivariable adjustment (odds ratio, 0.68; 95% confidence interval, 0.51–0.93). Other antihypertensive drugs, such as thiazide diuretics, which were reportedly helpful in preventing fractures, did not alter the bone fracture history and did not change among ARB users and non-users. Conclusions: The present study showed that administering ARB was significantly associated with a lower frequency of bone fracture history.

DOI： 10.1007/s10157-023-02385-3

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Association between iron status markers and kidney outcome in patients with chronic kidney disease

Fujisawa, H; Nakayama, M; Haruyama, N; Fukui, A; Yoshitomi, R; Tsuruya, K; Nakano, T; Kitazono, T

SCIENTIFIC REPORTS 13 ( 1 ) 18278 2023年10月（ ISSN:2045-2322 ）

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記述言語：英語出版者・発行元：Scientific Reports

Several studies conducted in patients with various stages of chronic kidney disease (CKD) have investigated the association of iron status markers, such as transferrin saturation (TSAT) and serum ferritin, with kidney outcomes. However, the associations were inconsistent and remain strongly debated. Therefore, we aimed to investigate whether TSAT and serum ferritin levels were associated with kidney outcome in such a population. In this study, 890 patients who were admitted for the evaluation of and education for CKD were prospectively followed. Primary kidney outcome was a composite of doubling of serum creatinine, end-stage kidney disease, or death due to kidney failure. Participants were divided into quartiles (Q1–Q4) according to TSAT or serum ferritin levels. During a median follow-up period of 2.8 years, kidney events occurred in 358 patients. In the multivariable Cox analyses, compared with Q3 of TSAT, the hazard ratios (95% confidence intervals) for Q1, Q2, and Q4 were 1.20 (0.87, 1.66), 1.38 (1.01, 1.87), and 1.14 (0.82, 1.59), respectively. Compared with Q2 of serum ferritin, lower and higher quartiles had a significantly increased risk for kidney outcome; hazard ratios (95% confidence intervals) for Q1, Q3, and Q4 were 1.64 (1.18, 2.27), 1.71 (1.24, 2.37), and 1.52 (1.10, 2.10), respectively. A Fine-Gray model with death before kidney events as a competing risk showed results similar to the above. In CKD, lower and higher ferritin levels were independent risk factors for kidney disease progression.

DOI： 10.1038/s41598-023-45580-8

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Characteristics and outcomes of unknown onset stroke: The Japan Stroke Data Bank

Wada, S; Yoshimura, S; Toyoda, K; Nakai, M; Sasahara, Y; Miwa, K; Koge, J; Ishigami, A; Shiozawa, M; Ogasawara, K; Kitazono, T; Nogawa, S; Iwanaga, Y; Miyamoto, Y; Minematsu, K; Koga, M

JOURNAL OF THE NEUROLOGICAL SCIENCES 453 120798 2023年10月（ ISSN:0022-510X eISSN:1878-5883 ）

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記述言語：英語出版者・発行元：Journal of the Neurological Sciences

Background: Clinical outcomes of unknown onset stroke (UOS) are influenced by the enlargement of the therapeutic time window for reperfusion therapy. This study aimed to investigate and describe the characteristics and clinical outcomes of patients with UOS. Methods: Patients with acute ischemic stroke (AIS) who were admitted within 24 h of their last known well time, from January 2017 to December 2020, were included. Data were obtained from a long-lasting nationwide hospital-based multicenter prospective registry: the Japan Stroke Data Bank. The co-primary outcomes were the National Institutes of Stroke Scale (NIHSS) scores on admission and unfavorable outcomes at discharge, corresponding to modified Rankin Scale (mRS) scores of 3–6. Results: Overall, 26,976 patients with AIS were investigated. Patients with UOS (N = 5783, 78 ± 12 years of age) were older than patients with known onset stroke (KOS) (N = 21,193, 75 ± 13 years of age). Age, female sex, higher premorbid mRS scores, atrial fibrillation, and congestive heart failure were associated with UOS in multivariate analysis. UOS was associated with higher NIHSS scores (median = 8 [interquartile range [IQR]: 3–19] vs. 4 [1–10], adjusted incidence rate ratio = 1.37 [95% CI: 1.35–1.38]) and unfavorable outcomes (52.1 vs. 33.6%, adjusted odds ratio = 1.27 [1.14–1.40]). Intergroup differences in unfavorable outcomes were attenuated among females (1.12 [0.95–1.32] vs. males 1.38 [1.21–1.56], P = 0.040) and in the subgroup that received reperfusion therapy (1.10 [0.92–1.33] vs. those who did not receive therapy 1.23 [1.08–1.39], P = 0.012). Conclusions: UOS was associated with unfavorable outcomes but to a lesser degree among females and patients receiving reperfusion therapy.

DOI： 10.1016/j.jns.2023.120798

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HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis 査読国際誌

Gastroenterology 2023年10月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association between iron status markers and kidney outcome in patients with chronic kidney disease 査読国際誌

Fujisawa H, Nakayama M, Haruyama N, Fukui A, Yoshitomi R, Tsuruya K, Nakano T, Kitazono T

Sci Rep 2023年10月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Characteristics and outcomes of unknown onset stroke: The Japan Stroke Data Bank 査読国際誌

Wada S, Yoshimura S, Toyoda K, Nakai M, Sasahara Y, Miwa K, Koge J, Ishigami A, Shiozawa M, Ogasawara K, Kitazono T, Nogawa S, Iwanaga Y, Miyamoto Y, Minematsu K, Koga M; Japan Stroke Data Bank Investigators

J Neurol Sci 2023年10月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Arginase 2 Promotes Cisplatin-Induced Acute Kidney Injury by the Inflammatory Response of Macrophages 査読国際誌

Uchida Y, Torisu K, Aihara S, Imazu N, Ooboshi H, Kitazono T, Nakano T

Lab Invest 2023年10月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Immunological analysis of hybrid neoantigen peptide encompassing class I/II neoepitope-pulsed dendritic cell vaccine 査読国際誌

Morisaki S, Onishi H, Morisaki T, Kubo M, Umebayashi M, Tanaka H, Koya N, Nakagawa S, Tsujimura K, Yoshimura S, Yew PY, Kiyotani K, Nakamura Y, Nakamura M, Kitazono T, Morisaki T

Front Immunol 2023年10月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Arginase 2 Promotes Cisplatin-Induced Acute Kidney Injury by the Inflammatory Response of Macrophages

Uchida, Y; Torisu, K; Aihara, S; Imazu, N; Ooboshi, H; Kitazono, T; Nakano, T

LABORATORY INVESTIGATION 103 ( 10 ) 100227 2023年10月（ ISSN:0023-6837 eISSN:1530-0307 ）

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記述言語：英語出版者・発行元：Laboratory Investigation

Acute kidney injury (AKI) is a complex clinical syndrome with a rapid decrease in renal function caused by several different etiologies, including sepsis, ischemia, and the administration of nephrotoxic drugs. Tubular arginase 2 (ARG2), an arginine-metabolic enzyme, is a potential therapeutic target for AKI, but it has not been confirmed under various AKI conditions. The aim of this study was to investigate ARG2 as a therapeutic target for cisplatin-induced AKI. Cisplatin-treated mice with a genetic deficiency in Arg2 had significant amelioration of renal dysfunction, characterized by decreased acute tubular damage and apoptosis. In contrast, cisplatin-induced tubular toxicity was not ameliorated in proximal tubule cells derived from Arg2-deficient mice. Immunohistochemical analysis demonstrated the increased infiltration of ARG2-positive macrophages in kidneys damaged by cisplatin. Importantly, cisplatin-treated Arg2 knockout mice exhibited a significant reduction in kidney inflammation, characterized by the decreased infiltration of inflammatory macrophages and reduced gene expression of interleukin (IL)-6 and IL-1β. The secretion of IL-6 and IL-1β induced by lipopolysaccharides was decreased in bone marrow–derived macrophages isolated from Arg2-deficient mice. Furthermore, the lipopolysaccharide-induced elevation of mitochondrial membrane potential and production of reactive oxygen species were reduced in bone marrow–derived macrophages lacking Arg2. These findings indicate that ARG2 promotes the inflammatory responses of macrophages through mitochondrial reactive oxygen species, resulting in the exacerbation of AKI. Therefore, targeting ARG2 in macrophages may constitute a promising therapeutic approach for AKI.

DOI： 10.1016/j.labinv.2023.100227

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Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis 査読国際誌

Yokote A, Imazu N, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Moriyama T, Miyawaki K, Akashi K, Kitazono T, Torisu T

J Gastroenterol 2023年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Cardiovascular Risk Factor Burden and Treatment Control in Patients with Chronic Kidney Disease: A Cross-Sectional Study 査読国際誌

Kitamura H, Tanaka S, Hiyamuta H, Shimamoto S, Tsuruya K, Nakano T, Kitazono T

J Atheroscler Thromb 2023年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Magnesium inhibits peritoneal calcification as a late-stage characteristic of encapsulating peritoneal sclerosis 査読国際誌

Aihara S, Yamada S, Matsueda S, Nagashima A, Torisu K, Kitazono T, Nakano T

Sci Rep 2023年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association between Serum C-Reactive Protein Concentrations and Risk of Cancer-Related Mortality in Patients Undergoing Hemodialysis: 10-Year Outcomes of the Q-Cohort Study

Uchida, Y; Nakano, T; Hiyamuta, H; Kitamura, H; Taniguchi, M; Ooboshi, H; Tsuruya, K; Kitazono, T

BLOOD PURIFICATION 52 ( 7-8 ) 694 - 701 2023年9月（ ISSN:0253-5068 eISSN:1421-9735 ）

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記述言語：英語出版者・発行元：Blood Purification

Cancer constitutes a major source of morbidity and mortality among people undergoing hemodialysis (HD). A systemic inflammatory response is associated with the incidence and prognosis of cancer in the general population. However, the effect of systemic inflammation on cancer-related mortality in patients undergoing HD remains unclear. Methods: We analyzed 3,139 patients registered in the Q-Cohort Study, which is a multicenter, observational cohort study of patients on hemodialysis in Japan. The primary outcome was cancer-related mortality during a 10-year follow-up. The covariate of interest was serum C-reactive protein (CRP) concentrations at baseline. The patients were divided into tertiles based on their serum CRP concentrations at baseline (tertile [T] 1: ≤0.07; T2: 0.08-0.24; and T3: ≥0.25). The association between serum CRP concentrations and cancer-related mortality was calculated using the Cox proportional hazards model and the Fine-Gray subdistribution hazards model with non-cancer-related death as a competing risk. Results: During the 10-year follow-up, 216 patients died of cancer. In the multivariable analysis, the risk of cancer-related mortality in the highest tertile (T3) of serum CRP concentrations was significantly higher than that in the lowest tertile (T1) (multivariable-adjusted hazard ratio [95% confidence interval]: 1.68 [1.15-2.44]). This association remained consistent in the competing risk model, in which the subdistribution hazard ratio was 1.47 and the 95% confidence interval was 1.00-2.14 for T3 compared with T1. Conclusion: Higher serum CRP concentrations are associated with an increased risk of cancer-related mortality in patients undergoing maintenance HD.

DOI： 10.1159/000530846

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Sex differences in the association between urate metabolism and kidney outcomes in patients with chronic kidney disease 査読国際誌

Haruyama N, Nakayama M, Fukui A, Yoshitomi R, Tsuruya K, Nakano T, Kitazono T

Clin Exp Nephrol 2023年8月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Acrolein produced during acute kidney injury promotes tubular cell death

Aihara, S; Torisu, K; Hirashima, Y; Kitazono, T; Nakano, T

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 666 137 - 145 2023年7月（ ISSN:0006-291X eISSN:1090-2104 ）

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記述言語：英語出版者・発行元：Biochemical and Biophysical Research Communications

Acute kidney injury is an important global health concern as it is associated with high morbidity and mortality. Polyamines, essential for cell growth and proliferation, are known to inhibit cardiovascular disease. However, under conditions of cellular damage, toxic acrolein is produced from polyamines by the enzyme spermine oxidase (SMOX). We used a mouse renal ischemia-reperfusion model and human proximal tubule cells (HK-2) to investigate whether acrolein exacerbates acute kidney injury by renal tubular cell death. Acrolein visualized by acroleinRED was increased in ischemia-reperfusion kidneys, particularly in tubular cells. When HK-2 cells were cultured under 1% oxygen for 24 h, then switched to 21% oxygen for 24 h (hypoxia-reoxygenation), acrolein accumulated and SMOX mRNA and protein levels were increased. Acrolein induced cell death and fibrosis-related TGFB1 mRNA in HK-2 cells. Administration of the acrolein scavenger cysteamine suppressed the acrolein-induced upregulation of TGFB1 mRNA. Cysteamine also inhibited a decrease in the mitochondrial membrane potential observed by MitoTrackerCMXRos, and cell death induced by hypoxia-reoxygenation. The siRNA-mediated knockdown of SMOX also suppressed hypoxia-reoxygenation-induced acrolein accumulation and cell death. Our study suggests that acrolein exacerbates acute kidney injury by promoting tubular cell death during ischemia-reperfusion injury. Treatment to control the accumulation of acrolein might be an effective therapeutic option for renal ischemia-reperfusion injury.

DOI： 10.1016/j.bbrc.2023.05.029

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Acrolein produced during acute kidney injury promotes tubular cell death 査読国際誌

Aihara S, Torisu K, Hirashima Y, Kitazono T, Nakano T

Biochem Biophys Res Commun 2023年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Incidence and risks of coronary heart disease and heart failure in Japanese patients with type 2 diabetes mellitus: The Fukuoka diabetes registry 査読国際誌

Iwase M, Ohkuma T, Fujii H, Oku Y, Higashi T, Oshiro A, Ide H, Nakamura U, Kitazono T

Diabetes Res Clin Pract 2023年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Usefulness of Serum Leucine-Rich Alpha-2 Glycoprotein as a Surrogate Marker of Small Bowel Mucosal Injury in Crohn's Disease 査読国際誌

Saiki T, Torisu T, Harada A, Kajiya Y, Taniguchi Y, Morisaki S, Umeno J, Suekane H, Kitazono T

Inflamm Intest Dis 2023年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association between decreases in serum uric acid levels and unfavorable outcomes after ischemic stroke: A multicenter hospital-based observational study

Nakamura, K; Ueki, K; Matsuo, R; Kiyohara, T; Irie, F; Wakisaka, Y; Ago, T; Kamouchi, M; Kitazono, T

PLOS ONE 18 ( 6 ) e0287721 2023年6月（ ISSN:1932-6203 ）

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記述言語：英語出版者・発行元：PLoS ONE

Background The association between clinical outcomes in ischemic stroke patients and decreases in serum uric acid levels, which often occur during the acute phase, remains unknown. Herein, we aimed to investigate the association using a large-scale, multicenter stroke registry. Methods We analyzed 4,621 acute ischemic stroke patients enrolled in the Fukuoka Stroke Registry between June 2007 and September 2019 whose uric acid levels were measured at least twice during hospitalization (including on admission). The study outcomes were poor functional outcome (modified Rankin Scale score ≥3) and functional dependence (modified Rankin Scale score 3–5) at 3 months after stroke onset. Changes in uric acid levels after admission were evaluated using a decrease rate that was classified into 4 sex-specific grades ranging from G1 (no change/increase after admission) to G4 (most decreased). Multivariable logistic regression analyses were used to assess the associations between decreases in uric acid levels and the outcomes. Results The frequencies of the poor functional outcome and functional dependence were lowest in G1 and highest in G4. The odds ratios (95% confidence intervals) of G4 were significantly higher for poor functional outcome (2.66 [2.05–3.44]) and functional dependence (2.61 [2.00–3.42]) when compared with G1 after adjusting for confounding factors. We observed no heterogeneity in results for subgroups categorized according to age, sex, stroke subtype, neurological severity, chronic kidney disease, or uric acid level on admission. Conclusions Decreases in serum uric acid levels were independently associated with unfavorable outcomes after acute ischemic stroke.

DOI： 10.1371/journal.pone.0287721

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Changes in the Eicosapentaenoic Acid to Arachidonic Acid Ratio in Serum over 10 Years in a Japanese Community: The Hisayama Study

Honda, T; Chen, SM; Hata, J; Shibata, M; Furuta, Y; Oishi, E; Sakata, S; Kitazono, T; Ninomiya, T

Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 30 ( 6 ) 589 - 600 2023年6月（ ISSN:13403478 eISSN:18803873 ）

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記述言語：英語出版者・発行元：一般社団法人日本動脈硬化学会

Aim: Circulating omega-3 and omega-6 polyunsaturated fatty acids may to contribute to cardiovascular health at the population level. Over a decade, we investigated changes in the serum eicosapentaenoic acid (EPA) to arachidonic acid (AA) ratio, and in serum concentrations of the individual fatty acids, in a Japanese community. Methods: Community surveys took place in 2002–2003 and 2012–2013 in a rural area of Japan. The community surveys included 3,194 and 3,220 community dwellers aged ≥ 40 years who did not take EPA medication in 2002–2003 and 2012–2013, respectively. Fatty acid fractionations in serum were measured using a gas chromatography method. Changes in the serum EPA/AA ratio over time were examined using linear mixed models. Results: Overall, the average serum EPA/AA ratio decreased over the 10 years. A decreasing trend in the serum EPA/AA ratio occurred in all age groups except participants aged ≥ 80 years, with larger decreases in the younger age groups. A similar decline in serum EPA/AA ratio occurred in participants with and those without lipid-lowering therapy. Serum EPA concentrations were slightly increased in the whole population but remained stable or even decreased in participants aged 40–69. In contrast, the average serum AA concentrations increased in all age groups. Conclusion: In a Japanese community, the serum EPA/AA ratio decreased over 10 years at the population level, especially in middle-aged participants.

DOI： 10.5551/jat.63727

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CiNii Research
Spermidine from arginine metabolism activates Nrf2 and inhibits kidney fibrosis 査読国際誌

Aihara S, Torisu K, Uchida Y, Imazu N, Nakano T, Kitazono T

Commun Biol 2023年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Changes in the Eicosapentaenoic Acid to Arachidonic Acid Ratio in Serum over 10 Years in a Japanese Community: The Hisayama Study 査読国際誌

Honda T, Chen S, Hata J, Shibata M, Furuta Y, Oishi E, Sakata S, Kitazono T, Ninomiya T

J Atheroscler Thromb 2023年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of white matter lesions and brain atrophy with the development of dementia in a community: the Hisayama Study 査読国際誌

Nakazawa T, Ohara T, Hirabayashi N, Furuta Y, Hata J, Shibata M, Honda T, Kitazono T, Nakao T, Ninomiya T

Psychiatry Clin Neurosci 2023年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association between decreases in serum uric acid levels and unfavorable outcomes after ischemic stroke: A multicenter hospital-based observational study 査読国際誌

Nakamura K, Ueki K, Matsuo R, Kiyohara T, Irie F, Wakisaka Y, Ago T, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators

PLoS One 2023年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Continuous use of antithrombotic medications during peri-endoscopic submucosal dissection period for colorectal lesions: A propensity score matched study 査読国際誌

Kawasaki K, Torisu T, Esaki M, Eizuka M, Kawatoko S, Kumei T, Hirai M, Kondo M, Fujioka S, Fuyuno Y, Matsuno Y, Umeno J, Moriyama T, Kitazono T, Sugai T, Matsumoto T

J Gastroenterol Hepatol 2023年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Serum Mac-2 Binding Protein Glycosylation Isomer Concentrations Are Associated With Incidence of Type 2 Diabetes 査読国際誌

Higashioka M, Hirakawa Y, Hata J, Honda T, Sakata S, Shibata M, Kitazono T, Osawa H, Ninomiya T

J Clin Endocrinol Metab 2023年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Small bowel capsule endoscopy examination and open access database with artificial intelligence: The SEE-artificial intelligence project 査読国際誌

Yokote A, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Yoshida Y, Imazu N, Miyazono S, Moriyama T, Kitazono T, Torisu T

DEN Open 2023年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of white matter lesions and brain atrophy with the development of dementia in a community: the Hisayama Study

Nakazawa, T; Ohara, T; Hirabayashi, N; Furuta, Y; Hata, J; Shibata, M; Honda, T; Kitazono, T; Nakao, T; Ninomiya, T

PSYCHIATRY AND CLINICAL NEUROSCIENCES 77 ( 6 ) 330 - 337 2023年6月（ ISSN:1323-1316 eISSN:1440-1819 ）

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記述言語：英語出版者・発行元：Psychiatry and Clinical Neurosciences

Aim: To investigate the association of white matter lesions volume (WMLV) levels with dementia risk and the association between dementia risk and the combined measures of WMLV and either total brain atrophy or dementia-related gray matter atrophy in a general older population. Methods: One thousand one hundred fifty-eight Japanese dementia-free community-residents aged ≥65 years who underwent brain magnetic resonance imaging were followed for 5.0 years. WMLV were segmented using the Lesion Segmentation Toolbox. Total brain volume (TBV) and regional gray matter volume were estimated by voxel-based morphometry. The WMLV-to-intracranial brain volume ratio (WMLV/ICV) was calculated, and its association with dementia risk was estimated using Cox proportional hazard models. Total brain atrophy, defined as the TBV-to-ICV ratio (TBV/ICV), and dementia-related regional brain atrophy defined based on our previous report were calculated. The association between dementia risk and the combined measures of WMLV/ICV and either total brain atrophy or the number of atrophied regions was also tested. Results: During the follow-up, 113 participants developed dementia. The risks of dementia increased significantly with higher WMLV/ICV levels. In addition, dementia risk increased additively both in participants with higher WMLV/ICV levels and lower TBV/ICV levels and in those with higher WMLV/ICV levels and a higher number of dementia-related brain regional atrophy. Conclusion: The risk of dementia increased significantly with higher WMLV/ICV levels. An additive increment in dementia risk was observed with higher WMLV/ICV levels and lower TBV/ICV levels or a higher number of dementia-related brain regional atrophy, suggesting the importance of prevention or control of cardiovascular risk factors.

DOI： 10.1111/pcn.13533

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Decreased Estimated Glomerular Filtration Rate and Proteinuria and Long-Term Outcomes After Ischemic Stroke: A Longitudinal Observational Cohort Study 査読国際誌

Ueki K, Matsuo R, Kuwashiro T, Irie F, Wakisaka Y, Ago T, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators

Stroke 2023年5月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Non-linear association between body weight and functional outcome after acute ischemic stroke 査読国際誌

Wakisaka K, Matsuo R, Matsumoto K, Nohara Y, Irie F, Wakisaka Y, Ago T, Nakashima N, Kamouchi M, Kitazono T

Sci Rep 2023年5月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Sex differences in cardiovascular risk, lifestyle, and psychological factors in patients with type 2 diabetes: the Fukuoka Diabetes Registry 査読国際誌

Ohkuma T, Iwase M, Fujii H, Kitazono T

Biol Sex Differ 2023年5月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
National trends in the outcomes of subarachnoid haemorrhage and the prognostic influence of stroke centre capability in Japan: retrospective cohort study 査読国際誌

Shimogawa T, Yoshimoto K, Onozuka D, Ogata S, Hagihara A, Saito N, Arai H, Miyamoto S, Tominaga T, Iihara K; J-ASPECT Study Collaborators

BMJ Open 2023年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
The Association of Controlling Nutritional Status Score and Prognostic Nutritional Index with Cardiovascular Diseases: the Fukuoka Kidney Disease Registry Study 査読国際誌

Tsuda S, Nakayama M, Tanaka S, Haruyama N, Yoshitomi R, Fukui A, Tsuruya K, Nakano T, Kitazono T

J Atheroscler Thromb 2023年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Simplified geriatric nutritional risk index for assessing nutritional status and stratifying mortality risk in patients receiving maintenance hemodialysis 査読国際誌

Yamada S, Arase H, Taniguchi M, Kitazono T, Nakano T

Ther Apher Dial 2023年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Design and methods of an open-label, randomized controlled trial to evaluate the effect of pemafibrate on proteinuria in CKD patients (PROFIT-CKD) 査読国際誌

Seki M, Nakano T, Tanaka S, Matsukuma Y, Funakoshi K, Ohkuma T, Kitazono T

Clin Exp Nephrol 2023年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
PDGFR β-positive cell-mediated post-stroke remodeling of fibronectin and laminin α 2 for tissue repair and functional recovery 査読国際誌

2023年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association between microscopic hematuria and albuminuria in patients with chronic kidney disease caused by diabetes and hypertension: the Fukuoka Kidney disease Registry Study 査読国際誌

Nakagawa K, Tanaka S, Tsuruya K, Kitazono T, Nakano T

Clin Exp Nephrol 2023年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Efficacy and Safety of Prasugrel vs Clopidogrel in Thrombotic Stroke Patients With Risk Factors for Ischemic Stroke Recurrence: A Double-blind, Phase III Study (PRASTRO-III) 査読国際誌

Kitazono T, Kamouchi M, Matsumaru Y, Nakamura M, Umemura K, Matsuo H, Koyama N, Tsutsumi J, Kimura K

J Atheroscler Thromb 2023年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Deletion of Nox4 enhances remyelination following cuprizone-induced demyelination by increasing phagocytic capacity of microglia and macrophages in mice 査読国際誌

Yamanaka K, Nakamura K, Shibahara T, Takashima M, Takaki H, Hidaka M, Komori M, Yoshikawa Y, Wakisaka Y, Ago T, Kitazono T

Glia 2023年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of gait speed with regional brain volumes and risk of dementia in older Japanese: The Hisayama study 査読国際誌

Tajimi T, Furuta Y, Hirabayashi N, Honda T, Hata J, Ohara T, Shibata M, Nakao T, Kitazono T, Nakashima Y, Ninomiya T

Arch Gerontol Geriatr 2023年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of gait speed with regional brain volumes and risk of dementia in older Japanese: The Hisayama study

Tajimi, T; Furuta, Y; Hirabayashi, N; Honda, T; Hata, J; Ohara, T; Shibata, M; Nakao, T; Kitazono, T; Nakashima, Y; Ninomiya, T

ARCHIVES OF GERONTOLOGY AND GERIATRICS 106 104883 2023年3月（ ISSN:0167-4943 eISSN:1872-6976 ）

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記述言語：英語出版者・発行元：Archives of Gerontology and Geriatrics

Background: To investigate the association of gait speed with regional brain volumes and the risk of incident dementia. Methods: A total of 1112 dementia-free Japanese residents aged ≥65 years who underwent brain magnetic resonance imaging were followed for 5.0 years (median). The participants were classified into the age- and sex-specific quartile levels of maximum gait speed. Regional gray matter volumes (GMV) and white matter hyperintensities volumes (WMHV) were measured by applying voxel-based morphometry methods. The cross-sectional association of maximum gait speed with regional GMV was examined using an analysis of covariance. We also estimated the association between maximum gait speed level and the risk of developing dementia using a Cox proportional hazards model. Mediation analyses were conducted to determine the contribution of regional brain volumes to the association between maximum gait speed and dementia. Results: Lower maximum gait speed was significantly associated with lower GMV of the total brain, frontal lobe, temporal lobe, cingulate gyrus, insula, hippocampus, amygdala, basal ganglia, thalamus, and cerebellum, and increased WMHV at baseline. During the follow-up, 108 participants developed dementia. The incidence rate of all dementias increased significantly with decreasing maximum gait speed after adjusting for potential confounders (P for trend = 0.03). The mediating effects of the GMV of the hippocampus, GMV of the insula, and WMHV were significant. Conclusions: Lower maximum gait speed was significantly associated with an increased risk of dementia. Reduced GMV of the hippocampus or insula, and an increase in WMHV was likely to be involved in this association.

DOI： 10.1016/j.archger.2022.104883

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Association between microscopic hematuria and albuminuria in patients with chronic kidney disease caused by diabetes and hypertension: the Fukuoka Kidney disease Registry Study

Nakagawa, K; Tanaka, S; Tsuruya, K; Kitazono, T; Nakano, T

CLINICAL AND EXPERIMENTAL NEPHROLOGY 27 ( 3 ) 227 - 235 2023年3月（ ISSN:1342-1751 eISSN:1437-7799 ）

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記述言語：英語出版者・発行元：Clinical and Experimental Nephrology

Background: The association between microscopic hematuria (MH) and albuminuria in patients with chronic kidney disease (CKD) caused by diabetes and hypertension remains unclear. Methods: The Fukuoka Kidney disease Registry Study is a Japanese multicenter prospective cohort study of 4476 patients with non-dialysis-dependent CKD. In this cohort, we conducted a cross-sectional study in 994 patients with diabetic nephropathy and hypertensive nephrosclerosis. Patients were divided into three groups according to erythrocyte count in urine sediment [T1: < 5/high power field (HPF); T2: 5–9/HPF; T3: ≥ 10/HPF]. Macroalbuminuria was defined as urinary albumin-creatinine ratio > 300 mg/g. Associations between the degree of MH (T1–T3) and the prevalence of macroalbuminuria were analyzed using logistic regression. Results: The prevalence of macroalbuminuria was 50.8%, 50.4%, and 67.4% in T1 (n = 725), T2 (n = 226), and T3 (n = 43), respectively. The multivariable-adjusted odds ratios for the presence of macroalbuminuria were 0.95 [95% confidence interval (CI) 0.65–1.39; P = 0.86] and 2.50 (95% CI 1.15–5.47; P = 0.022) for patients in T2 and T3, respectively, compared with patients in T1. Conclusions: MH with erythrocytes ≥ 10/HPF was significantly associated with increased prevalence of macroalbuminuria in patients with non-dialysis-dependent CKD caused by diabetes and hypertension.

DOI： 10.1007/s10157-022-02298-7

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Association between prevalence of laxative use and history of bone fractures and cardiovascular diseases in patients with chronic kidney disease: the Fukuoka Kidney disease Registry (FKR) study 査読国際誌

Yamada S, Tanaka S, Arase H, Hiyamuta H, Kitamura H, Tokumoto M, Mitsuiki K, Tsuruya K, Kitazono T, Nakano T

Clin Exp Nephrol 2023年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Painless thyroiditis mimicking relapse of hyperthyroidism during or after potassium iodide or thionamide therapy for Graves' disease resulting in remission 査読国際誌

Okamura K, Sato K, Fujikawa M, Bandai S, Ikenoue H, Kitazono T

Endocr J 2023年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association between prevalence of laxative use and history of bone fractures and cardiovascular diseases in patients with chronic kidney disease: the Fukuoka Kidney disease Registry (FKR) study

Yamada, S; Tanaka, S; Arase, H; Hiyamuta, H; Kitamura, H; Tokumoto, M; Mitsuiki, K; Tsuruya, K; Kitazono, T; Nakano, T

CLINICAL AND EXPERIMENTAL NEPHROLOGY 27 ( 2 ) 151 - 160 2023年2月（ ISSN:1342-1751 eISSN:1437-7799 ）

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記述言語：英語出版者・発行元：Clinical and Experimental Nephrology

Background: Constipation is a common complication in patients with chronic kidney disease (CKD) and is involved in the pathogenesis of dysbiosis and progression of CKD. However, little is known about its association with disorders of the bone–cardiovascular axis in patients with CKD. Methods: We performed a cross-sectional analysis of 3878 patients with CKD using the baseline dataset of the Fukuoka Kidney disease Registry study, as a multicenter, prospective cohort study of pre-dialysis CKD patients. The main exposure of interest was constipation defined as use of at least one type of laxative. The main outcomes were the histories of bone fractures and cardiovascular diseases (CVDs) as manifestations of disorders of the bone–cardiovascular axis. Results: The prevalences of laxative use and histories of bone fractures and CVDs increased as kidney function declined. Among the 3878 patients, 532 (13.7%) patients used laxatives, 235 (6.1%) patients had prior bone fractures, and 1001 (25.8%) patients had prior CVDs. Histories of bone fractures and CVDs were significantly more prevalent among laxative users (P < 0.05). Multivariable-adjusted logistic regression analysis revealed that patients with laxatives had a significantly higher odds ratios for histories of bone fractures and CVDs than those without laxatives [adjusted odds ratios (95% confidence intervals) 1.67 (1.20–2.31) and 1.70 (1.30–2.22), respectively, P < 0.05]. Conclusions: These results suggest that constipation indicated by laxative use is associated with increased prevalences of historical bone fractures and CVDs in pre-dialysis patients with CKD.

DOI： 10.1007/s10157-022-02289-8

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Intravenous nicardipine for Japanese patients with acute intracerebral hemorrhage: an individual participant data analysis 査読国際誌

Toyoda K, Yoshimura S, Fukuda-Doi M, Qureshi AI, Inoue M, Miwa K, Koga M; ATACH Trial Investigators; SAMURAI Investigators

Hypertens Res 2023年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association between hyporesponsiveness to erythropoiesis-stimulating agents and risk of brain hemorrhage in patients undergoing hemodialysis: the Q-Cohort Study 査読国際誌

Uchida Y, Nakano T, Kitamura H, Taniguchi M, Tsuruya K, Kitazono T

Clin Exp Nephrol 2023年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Intravenous Alteplase at 0.6 mg/kg for Unknown Onset Stroke with Prior Antithrombotic Medication: THAWS Randomized Clinical Trial 査読国際誌

Koga M, Inoue M, Miwa K, Yoshimura S, Fukuda-Doi M, Aoki J, Asakura K, Kanzawa T, Ohtaki M, Kamiyama K, Yakushiji Y, Igarashi S, Doijiri R, Ito Y, Takagi Y, Sasaki M, Kitazono T, Kimura K, Minematsu K, Yamamoto H, Toyoda K

J Atheroscler Thromb 2023年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association between hyporesponsiveness to erythropoiesis-stimulating agents and risk of brain hemorrhage in patients undergoing hemodialysis: the Q-Cohort Study

Uchida, Y; Nakano, T; Kitamura, H; Taniguchi, M; Tsuruya, K; Kitazono, T

CLINICAL AND EXPERIMENTAL NEPHROLOGY 27 ( 1 ) 79 - 88 2023年1月（ ISSN:1342-1751 eISSN:1437-7799 ）

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記述言語：英語出版者・発行元：Clinical and Experimental Nephrology

Background: Hyporesponsiveness to erythropoiesis-stimulating agents (ESAs) is associated with increased risks of all cause and cardiovascular mortality in patients undergoing hemodialysis (HD). However, the impact of the hematopoietic response to ESAs on the development of stroke, including brain hemorrhage and infarction, remains unclear. Methods: In total, 2886 patients undergoing maintenance HD registered in the Q-Cohort Study who were treated with ESAs were prospectively followed up for 4 years. The hematopoietic response to ESAs was evaluated by the erythropoietin resistance index (ERI), calculated by dividing the weekly dose of ESA by post-HD weight and hemoglobin (U/kg/week/g/dL). The primary outcomes were the incidences of brain hemorrhage and infarction. Patients were divided into quartiles based on their ERI at baseline (Q1, ≤ 4.1; Q2, 4.2–7.0; Q3, 7.1–11.2; and Q4, ≥ 11.3). The risks of brain hemorrhage and infarction were estimated using Cox proportional hazards models, adjusting for potential confounders. Results: During the 4 year follow-up period, 71 patients developed brain hemorrhage and 116 developed brain infarction. In the multivariable analysis, the incidence of brain hemorrhage in the highest quartile (Q4) was significantly higher than that in the lowest quartile (Q1) (hazard ratio [95% confidence interval], 2.18 [1.08–4.42]). However, the association between the ERI and the incidence of brain infarction was not significant. Conclusions: A higher ERI was associated with an increased risk of brain hemorrhage, but not brain infarction, in patients undergoing maintenance HD. A high ERI is thus an important risk factor for brain hemorrhage in these patients.

DOI： 10.1007/s10157-022-02278-x

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Association between Early Cognitive Impairment and Short-Term Functional Outcome in Acute Ischemic Stroke

Kiyohara, T; Kumai, Y; Yubi, T; Ishikawa, E; Wakisaka, Y; Ago, T; Kitazono, T

CEREBROVASCULAR DISEASES 52 ( 1 ) 61 - 67 2023年1月（ ISSN:1015-9770 eISSN:1421-9786 ）

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記述言語：英語出版者・発行元：Cerebrovascular Diseases

Background: Little is known about the association between poststroke cognitive impairment (PSCI) and functional outcome in the acute care phase of ischemic stroke and the influence of the clinical condition of acute stroke on this association. We examined this issue, taking into account stroke-related factors, in a hospital-based prospective study of patients with acute ischemic stroke. The same analysis was also performed after subsequent rehabilitation to investigate whether the association observed in the acute care phase persisted after that. For comparison, the same analysis was performed for pre-stroke dementia (PreSD). Methods: We included in the study a total of 923 patients with acute ischemic stroke who were admitted to a hospital from 2012 to 2020 in Japan. Cognitive function was assessed using the Mini-Mental State Examination and Raven's Colored Progressive Matrices test at an average of 6.3 days after stroke onset. The subjects were divided into three groups with normal cognition, PSCI, and PreSD. Study outcome was a poor functional outcome, defined as a modified Rankin Scale score of ≥3 at the end of acute care (median 21 days after admission). Among total subjects, 460 were also assessed for poor functional outcome after rehabilitation (median 77 days after admission). A logistic regression model was applied in this study. Results: Patients with PSCI and PreSD had higher median National Institute of Health Stroke Scale scores than those with normal cognition (median [IQR]: 3 [2-6], 4 [2-12], and 2 [1-4], respectively). The age- and sex-adjusted cumulative incidence of poor functional outcome was significantly higher in patients with PSCI and PreSD than in those with normal cognition in the acute care and rehabilitation phases. In the acute care phase, these associations remained significant after adjustment for stroke-related factors and other confounders (multivariable-adjusted odds ratio [95% CI] for PSCI vs. normal cognition: 3.28 [2.07-5.20]; for PreSD: 2.39 [1.40-4.08]). Similar results were observed in the rehabilitation phase (for PSCI: 2.48 [1.31-4.70]; for PreSD: 3.92 [1.94-7.92]). Conclusions: Our findings suggest that PSCI, as well as PreSD, is possibly associated with the development of poor functional outcome in the acute care phase of ischemic stroke, and this association continues thereafter.

DOI： 10.1159/000524839

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Cardiovascular Risk Factor Burden and Treatment Control in Patients with Chronic Kidney Disease: A Cross-Sectional Study

Kitamura, H; Tanaka, S; Hiyamuta, H; Shimamoto, S; Tsuruya, K; Nakano, T; Kitazono, T; FKR Study Collaboration Grp

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 30 ( 9 ) 1210 - 1228 2023年（ ISSN:1340-3478 eISSN:1880-3873 ）

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出版者・発行元：Journal of Atherosclerosis and Thrombosis

Aim: Cardiovascular disease is a life-threatening chronic kidney disease (CKD) complication. Although cardiovascular risk factor management is significant in patients with CKD, there are few reports that detail the frequency of complications and the treatment of cardiovascular risk factors at different stages of CKD in clinical practice. Methods: There were a total of 3,407 patients with non-dialysis-dependent CKD who participated in the Fukuoka Kidney disease Registry Study, and they were cross-sectionally analyzed. The patients were classified into five groups based on their estimated glomerular filtration rate and urinary albumin to creatinine ratio according to Kidney Disease: Improving Global Outcomes 2012 guidelines, which recommend low, moderate, high, very high, and extremely high risk groups. The primary outcomes were the cardiovascular risk factor burden and the treatment status of cardiovascular risk factors. Using a logistic regression model, the association between the CKD groups and the treatment status of each risk factor was examined. Results: The proportion of patients with hypertension, diabetes mellitus, and dyslipidemia significantly increased as CKD progressed, whereas the proportion of patients who achieved cardiovascular risk factor treatment targets significantly decreased. In the multivariable analysis, the odds ratios (ORs) of uncontrolled treatment targets were significantly higher for hypertension (OR 3.68) in the extremely high risk group than in the low risk group. Conclusions: Patients with non-dialysis-dependent CKD demonstrate an increased cardiovascular risk factor burden with greater severity of CKD. Extremely high risk CKD is associated with difficulty in managing hypertension.

DOI： 10.5551/jat.63891

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Onset of type 1 diabetes during bone growth period is associated with increased prevalence of bone fracture: A post-hoc analysis of a cross-sectional study 査読国際誌

Komorita Y, Minami M, Maeda Y, Kishita R, Ohkuma T, Kitazono T

J Diabetes Investig 2022年12月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Cardiovascular Risk Factor Burden and Treatment Control in Patients with Chronic Kidney Disease: A Cross-Sectional Study 査読国際誌

Kitamura H, Tanaka S, Hiyamuta H, Shimamoto S, Tsuruya K, Nakano T, Kitazono T; FKR Study Collaboration Group

J Atheroscler Thromb 2022年12月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
CKD, Brain Atrophy, and White Matter Lesion Volume: The Japan Prospective Studies Collaboration for Aging and Dementia 査読国際誌

Maki K, Ohara T, Hata J, Shibata M, Hirabayashi N, Honda T, Sakata S, Furuta Y, Akiyama M, Yamasaki K, Tatewaki Y, Taki Y, Kitazono T, Mikami T, Maeda T, Ono K, Mimura M, Nakashima K, Iga JI, Takebayashi M, Ninomiya T; Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) study group

Kidney Med 2022年12月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Long-Term Trends in The 5-Year Risk of Recurrent Stroke over A Half Century in A Japanese Community: The Hisayama Study 査読国際誌

Nakanishi Y, Furuta Y, Hata J, Yubi T, Oishi E, Sakata S, Hirakawa Y, Wakisaka Y, Ago T, Kitazono T, Ninomiya T

J Atheroscler Thromb 2022年12月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Serum lipopolysaccharide-binding protein levels and the incidence of metabolic syndrome in a general Japanese population: the Hisayama Study 査読国際誌

Tomooka S, Oishi E, Asada M, Sakata S, Hata J, Chen S, Honda T, Suzuki K, Watanabe H, Murayama N, Wada N, Kitazono T, Ninomiya T

J Epidemiol 2022年12月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Stroke genetics informs drug discovery and risk prediction across ancestries 査読国際誌

Nature 2022年11月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Current antihypertensive treatment and treatment-resistant hypertension in Japanese patients with chronic kidney disease 招待査読国際誌

Tsuchimoto A, Tanaka S, Kitamura H, Hiyamuta H, Tsuruya K, Kitazono T, Nakano T; Fukuoka Kidney disease Registry (FKR) study corporation

Clin Exp Nephrol 2022年11月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Glucose degradation products in peritoneal dialysis solution impair angiogenesis by dysregulating angiogenetic factors in endothelial and vascular smooth muscle cells 査読国際誌

Aihara S, Nakano T, Torisu K, Kitazono T

Clin Exp Nephrol 2022年11月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Low intake of β carotene and dietary fiber from vegetables and fruits in patients with chronic kidney disease 査読国際誌

2022年11月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Serum alkaline phosphatase and infection-related mortality in hemodialysis patients: ten-year outcomes of the Q-cohort study 査読国際誌

Kitamura H, Yotsueda R, Hiyamuta H, Taniguchi M, Tanaka S, Yamada S, Tsuruya K, Nakano T, Kitazono T

Clin Exp Nephrol 2022年11月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Associations Between Adherence to Evidence-Based, Stroke Quality Indicators and Outcomes of Acute Reperfusion Therapy 査読国際誌

Ren N, Ogata S, Kiyoshige E, Nishimura K, Nishimura A, Matsuo R, Kitazono T, Higashi T, Ogasawara K, Iihara K; Close The Gap-Stroke, J-ASPECT Study Collaborators*

Stroke 2022年11月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Arginine Metabolism Regulates the Transcription Factor Nrf2 and Prevents Renal Interstitial Fibrosis Through Tubular Spermidine Production

Aihara, S; Torisu, K; Nakano, T; Kitazono, T

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 33 ( 11 ) 589 - 589 2022年11月（ ISSN:1046-6673 eISSN:1533-3450 ）

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Web of Science
Cardiovascular Risk Factor Burden and Treatment Control in Patients With CKD: The Fukuoka Kidney Disease Registry (FKR) Study

Kitamura, H; Tanaka, S; Hiyamuta, H; Shimamoto, S; Tsuruya, K; Nakano, T; Kitazono, T

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 33 ( 11 ) 219 - 220 2022年11月（ ISSN:1046-6673 eISSN:1533-3450 ）

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Associations Between Adherence to Evidence-Based, Stroke Quality Indicators and Outcomes of Acute Reperfusion Therapy

Ren, NC; Ogata, S; Kiyoshige, E; Nishimura, K; Nishimura, A; Matsuo, R; Kitazono, T; Higashi, T; Ogasawara, K; Iihara, K

STROKE 53 ( 11 ) 3359 - 3368 2022年11月（ ISSN:0039-2499 eISSN:1524-4628 ）

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記述言語：英語出版者・発行元：Stroke

Background: Quality indicators (QIs) are an accepted tool for measuring a hospital's performance in routine care. We examined national trends in adherence to the QIs developed by the Close The Gap-Stroke program by combining data from the health insurance claims database and electronic medical records, and the association between adherence to these QIs and early outcomes in patients with acute ischemic stroke in Japan. Methods: In the present study, patients with acute ischemic stroke who received acute reperfusion therapy in 351 Close The Gap-Stroke-participating hospitals were analyzed retrospectively. The primary outcomes were changes in trends for adherence to the defined QIs by difference-in-difference analysis and the effects of adherence to distinct QIs on in-hospital outcomes at the individual level. A mixed logistic regression model was adjusted for patient and hospital characteristics (eg, age, sex, number of beds) and hospital units as random effects. Results: Between 2013 and 2017, 21 651 patients (median age, 77 years; 43.0% female) were assessed. Of the 25 defined measures, marked and sustainable improvement in the adherence rates was observed for door-to-needle time, door-to-puncture time, proper use of endovascular thrombectomy, and successful revascularization. The in-hospital mortality rate was 11.6%. Adherence to 14 QIs lowered the odds of in-hospital mortality (odds ratio [95% CI], door-to-needle <60 min, 0.80 [0.69-0.93], door-to-puncture <90 min, 0.80 [0.67-0.96], successful revascularization, 0.40 [0.34-0.48]), and adherence to 11 QIs increased the odds of functional independence (modified Rankin Scale score 0-2) at discharge. Conclusions: We demonstrated national marked and sustainable improvement in adherence to door-to-needle time, door-to-puncture time, and successful reperfusion from 2013 to 2017 in Japan in patients with acute ischemic stroke. Adhering to the key QIs substantially affected in-hospital outcomes, underlining the importance of monitoring the quality of care using evidence-based QIs and the nationwide Close The Gap-Stroke program.

DOI： 10.1161/STROKEAHA.121.038483

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The presence of sodium glucose co-transporter 2 in mesangial cells and pericytes and its roles in mesangial lesions and in capillaries under diabetic and ischemic conditions 査読国際誌

Wakisaka M, Nakamura K, Kitazono T

Diabetes Res Clin Pract 2022年10月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Active commuting, commuting modes and the risk of diabetes: 14-year follow-up data from the Hisayama study 査読国際誌

Honda T, Hirakawa Y, Hata J, Chen S, Shibata M, Sakata S, Furuta Y, Higashioka M, Oishi E, Kitazono T, Ninomiya T

J Diabetes Investig 2022年10月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Day-to-Day Blood Pressure Variability and Risk of Incident Chronic Kidney Disease in a General Japanese Population 査読国際誌

Sasaki T, Sakata S, Oishi E, Furuta Y, Honda T, Hata J, Tsuboi N, Kitazono T, Yokoo T, Ninomiya T

J Am Heart Assoc 2022年10月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Active commuting, commuting modes and the risk of diabetes: 14-year follow-up data from the Hisayama study

Honda, T; Hirakawa, Y; Hata, J; Chen, SM; Shibata, M; Sakata, S; Furuta, Y; Higashioka, M; Oishi, E; Kitazono, T; Ninomiya, T

JOURNAL OF DIABETES INVESTIGATION 13 ( 10 ) 1677 - 1684 2022年10月（ ISSN:2040-1116 eISSN:2040-1124 ）

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記述言語：英語出版者・発行元：Journal of Diabetes Investigation

Aims/Introduction: We aimed to investigate the association of active commuting (cycling or walking to work), as well as the association of the individual commuting modes, with the risk of diabetes in a prospective cohort of community-dwelling adults in Japan. Material and Methods: A total of 1,270 residents aged 40–79 years were followed up for a median of 14 years. Active commuting was defined as either cycling or walking to work. A Cox proportional hazards model was used to examine the association of active commuting with the risk of diabetes. Associations for different forms of active commuting (cycling, walking and mixed modes of cycling or walking with non-active components) were also examined. Results: During the follow-up period, 191 participants developed diabetes. Active commuting was associated with a lower risk of diabetes than non-active commuting after adjustment for potential confounders (hazard ratio [HR] 0.54, 95% confidence interval [CI] 0.31–0.92). With regard to the commuting modes, the risk of diabetes was significantly lower in individuals who commuted by cycling alone (HR 0.46, 95% CI 0.22–0.98), and tended to be lower in individuals who commuted by walking alone (HR 0.14, 95% CI 0.02–1.02) compared with that in individuals with non-active commuting. Meanwhile, no significant associations were observed for the mixed mode of walking and non-active commuting (HR 1.69, 95% CI 0.77–3.71). Conclusions: Active commuting, particularly that consisting exclusively of cycling or walking, was associated with a reduced risk of diabetes. Our findings support a public health policy that promotes the choice of active commuting for the prevention of diabetes.

DOI： 10.1111/jdi.13844

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Risks of Mortality and Airflow Limitation in Japanese Individuals with Preserved Ratio Impaired Spirometry 査読国際誌

Washio Y, Sakata S, Fukuyama S, Honda T, Kan-O K, Shibata M, Hata J, Inoue H, Kitazono T, Matsumoto K, Ninomiya T

Am J Respir Crit Care Med 2022年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Prevalence, treatment status, and predictors of anemia and erythropoietin hyporesponsiveness in Japanese patients with non-dialysis-dependent chronic kidney disease: a cross-sectional study 査読国際誌

Tanaka S, Kitamura H, Tsuruya K, Kitazono T, Nakano T; FKR Study Collaboration Group

Clin Exp Nephrol 2022年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Changes in the Eicosapentaenoic Acid to Arachidonic Acid Ratio in Serum over 10 Years in a Japanese Community: The Hisayama Study 査読国際誌

Honda T, Chen S, Hata J, Shibata M, Furuta Y, Oishi E, Sakata S, Kitazono T, Ninomiya T

J Atheroscler Thromb 2022年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Filamin A Variant as a Possible Second-Hit Gene Promoting Moyamoya Disease-like Vascular Formation Associated With RNF213 p.R4810K Variant 査読国際誌

Ikeuchi Y, Kitayama J, Sahara N, Okata T, Miyake N, Matsumoto N, Kitazono T, Ago T

Neurol Genet. 2022年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Potential therapeutic targets discovery by transcriptome analysis of an in vitro human gastric signet ring carcinoma model 査読国際誌

Yamaguchi K, Yoshihiro T, Ariyama H, Ito M, Nakano M, Semba Y, Nogami J, Tsuchihashi K, Yamauchi T, Ueno S, Isobe T, Shindo K, Moriyama T, Ohuchida K, Nakamura M, Nagao Y, Ikeda T, Hashizume M, Konomi H, Torisu T, Kitazono T, Kanayama T, Tomita H, Oda Y, Kusaba H, Maeda T, Akashi K, Baba E

Gastric Cancer 2022年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Solid-type poorly differentiated adenocarcinoma of the stomach: A characteristic morphology reveals a distinctive immunoregulatory tumor microenvironment 査読国際誌

Kawatoko S, Kohashi K, Torisu T, Sasaki T, Umekita S, Oki E, Nakamura M, Kitazono T, Oda Y.

Pathol Res Pract 2022年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Prediction of intracranial lesions in patients with consciousness disturbance by ultrasonography in the intensive care unit 査読国際誌

Shono Y, Mezuki S, Akahoshi T, Nishihara M, Kaku N, Maki J, Tokuda K, Kitazono T

J Int Med Res 2022年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association between Multimorbidity and Kidney Function among Patients with Non-Dialysis-Dependent CKD: The Fukuoka Kidney Disease Registry Study

Tanaka, S; Nakano, T; Hiyamuta, H; Tsuruya, K; Kitazono, T

Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 29 ( 8 ) 1249 - 1264 2022年8月（ ISSN:13403478 eISSN:18803873 ）

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記述言語：英語出版者・発行元：一般社団法人日本動脈硬化学会

Aim: Individuals with chronic kidney disease (CKD) have a high prevalence of comorbidities, including cardiovascular disease (CVD) and its risk factors. However, epidemiological results to assess the association between multimorbidity and kidney function among the CKD population remains limited. Methods: We performed a cross-sectional analysis of the association between 23 comorbid conditions and reduced kidney function in 4,476 patients with non-dialysis-dependent CKD enrolled in a multicenter cohort in Japan. Reduced kidney function was defined as an estimated glomerular filtration rate of ≤ 60 mL/min/1.73 m2. Results: The mean age of patients was 67 years (male, 56.0%). The prevalence of hypertension, diabetes mellitus, dyslipidemia, prior CVD, cancer, and bone fracture, which are the major comorbidities, was 83.3%, 28.7%, 45.9%, 23.3%, 12.7%, and 6.3%, respectively. Multivariable-adjusted analyses revealed that age, male sex, hypertension, dyslipidemia, prior CVD, body mass index, urinary protein excretion, and underlying kidney disease were independent factors associated with reduced kidney function. Importantly, the odds ratios (ORs) for reduced kidney function increased linearly as the number of major comorbid conditions increased (OR for 1–2 conditions: 2.22, 95% confidence interval [CI]: 1.65–2.97; OR for 3–4 conditions: 3.04, 95% CI: 2.12–4.37; OR for ≥ 5 conditions: 4.37, 95% CI: 1.75–10.9). The upward trend in OR was more pronounced with cardiovascular comorbidities but not significant with non-cardiovascular comorbidities. Conclusions: In conclusion, we observed an independent association between cardiovascular comorbidity and its risk factors and reduced kidney function. The results of this study highlight the importance of managing multimorbidity among patients with CKD.

DOI： 10.5551/jat.62900

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CiNii Research
Iodide-sensitive Graves' hyperthyroidism and the strategy for resistant or escaped patients during potassium iodide treatment 査読国際誌

Okamura K, Sato K, Fujikawa M, Bandai S, Ikenoue H, Kitazono T

Endocr J 2022年8月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Hyperoxemia is Associated With Poor Neurological Outcomes in Patients With Out-of-Hospital Cardiac Arrest Rescued by Extracorporeal Cardiopulmonary Resuscitation: Insight From the Nationwide Multicenter Observational JAAM-OHCA (Japan Association for Acute Medicine) Registry 査読国際誌

Nishihara M, Hiasa KI, Enzan N, Ichimura K, Iyonaga T, Shono Y, Kashiura M, Moriya T, Kitazono T, Tsutsui H

J Emerg Med 2022年8月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association between Multimorbidity and Kidney Function among Patients with Non-Dialysis-Dependent CKD: The Fukuoka Kidney Disease Registry Study 査読国際誌

Tanaka S, Nakano T, Hiyamuta H, Tsuruya K, Kitazono T

J Atheroscler Thromb 2022年8月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Remote ischemic conditioning for acute ischemic stroke part 2: Study protocol for a randomized controlled trial 査読国際誌

Ishizuka K, Hoshino T, Toi S, Mizuno T, Hosoya M, Saito M, Sato Y, Yagita Y, Todo K, Sakaguchi M, Ohashi T, Maruyama K, Hino S, Honma Y, Doijiri R, Yamagami H, Iguchi Y, Hirano T, Kimura K, Kitazono T, Kitagawa K

Front Neurol 2022年8月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community

Mihara, A; Ohara, T; Hata, J; Chen, S; Honda, T; Tamrakar, S; Isa, A; Wang, D; Shimizu, K; Katakura, Y; Yonemoto, K; Nakao, T; Kitazono, T; Ninomiya, T

SCIENTIFIC REPORTS 12 ( 1 ) 12427 2022年7月（ ISSN:2045-2322 ）

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記述言語：英語出版者・発行元：Scientific Reports

We examined the association of serum s-adenosylmethionine (SAM), s-adenosylhomocysteine (SAH) (methionine metabolites), and their ratio on the risk of dementia and death in a community-dwelling population of older Japanese individuals. 1371 residents of Hisayama, Japan, aged 65 years or older and without dementia, were followed for a median of 10.2 years (2007–2017). We divided serum SAM, SAH, and SAM/SAH ratio into quartiles. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) of serum SAM, SAH, and SAM/SAH ratio levels on the risk of a composite outcome of all-cause dementia or death, and each outcome. During the follow-up, 635 participants developed all-cause dementia and/or died, of which 379 participants developed dementia and 394 deaths occurred. The multivariable-adjusted HRs of the composite outcome decreased significantly with increasing serum SAM levels (P for trend = 0.01), while they increased significantly with higher serum SAH levels (P for trend = 0.03). Higher serum SAM/SAH ratio levels were significantly associated with a lower risk of the composite outcome (P for trend = 0.002), as well as with lower risk of each outcome. Our findings suggest that the balance of methionine metabolites may closely associate with the risk of dementia and death.

DOI： 10.1038/s41598-022-16242-y

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PubMed
Causes of ischemic stroke in young adults versus non-young adults: A multicenter hospital-based observational study 査読国際誌

Ohya Y, Matsuo R, Sato N, Irie F, Nakamura K, Wakisaka Y, Ago T, Kamouchi M, Kitazono T; Investigators for Fukuoka Stroke Registry

PLoS One 2022年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Fluid-attenuated inversion recovery vascular hyperintensity-diffusion-weighted imaging mismatch and functional outcome after endovascular reperfusion therapy for acute ischemic stroke 査読国際誌

Tokunaga K, Tokunaga S, Hara K, Yasaka M, Okada Y, Kitazono T, Tsumoto T

Interv Neuroradiol 2022年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Low-dose sodium-glucose cotransporter 2 inhibitor ameliorates ischemic brain injury in mice through pericyte protection without glucose-lowering effects 査読国際誌

Takashima M, Nakamura K, Kiyohara T, Wakisaka Y, Hidaka M, Takaki H, Yamanaka K, Shibahara T, Wakisaka M, Ago T, Kitazono T

Commun Biol 2022年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community 査読国際誌

Mihara A, Ohara T, Hata J, Chen S, Honda T, Tamrakar S, Isa A, Wang D, Shimizu K, Katakura Y, Yonemoto K, Nakao T, Kitazono T, Ninomiya T

Sci Rep 2022年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Causes of ischemic stroke in young adults versus non-young adults: A multicenter hospital-based observational study

Ohya Y., Matsuo R., Sato N., Irie F., Nakamura K., Wakisaka Y., Ago T., Kamouchi M., Kitazono T.

PLoS ONE 17 ( 7 July ) e0268481 2022年7月

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記述言語：英語出版者・発行元：PLoS ONE

Background Very few comparative studies have focused on the differences in the causes of ischemic stroke between young adults and non-young adults. This study was performed to determine what causes of ischemic stroke are more important in young adults than in non-young adults using a large-scale multicenter hospital-based stroke registry in Fukuoka, Japan. Methods and results We investigated data on 15,860 consecutive patients aged ≥18 years with acute ischemic stroke (mean age: 73.5 ± 12.4 years, 58.2% men) who were hospitalized between 2007 and 2019. In total, 779 patients were categorized as young adults (≤50 years of age). Although vascular risk factors, including hypertension, diabetes mellitus, and dyslipidemia, were less frequent in young adults than in non-young adults, the prevalence of diabetes mellitus and dyslipidemia in young adults aged >40 years were comparable to those of non-young adults. Lifestyle-related risk factors such as smoking, drinking, and obesity were more frequent in young adults than in non-young adults. As young adults became older, the proportions of cardioembolism and stroke of other determined etiologies decreased, but those of large-artery atherosclerosis and small-vessel occlusion increased. Some embolic sources (high-risk sources: arterial myxoma, dilated cardiomyopathy, and intracardiac thrombus; medium-risk sources: atrial septal defect, nonbacterial thrombotic endocarditis, patent foramen ovale, and left ventricular hypokinesis) and uncommon causes (vascular diseases: reversible cerebral vasoconstriction syndrome, moyamoya disease, other vascular causes, arterial dissection, and cerebral venous thrombosis; hematologic diseases: antiphospholipid syndrome and protein S deficiency) were more prevalent in young adults than in non-young adults, and these trends decreased with age. Conclusions Certain embolic sources and uncommon causes may be etiologically important causes of ischemic stroke in young adults. However, the contribution of conventional vascular risk factors and lifestyle-related risk factors is not negligible with advancing age, even in young adults.

DOI： 10.1371/journal.pone.0268481

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PubMed
Relationship between platelet aggregation and stroke risk after percutaneous coronary intervention: a PENDULUM analysis 査読国際誌

Matsumaru Y, Kitazono T, Kadota K, Nakao K, Nakagawa Y, Shite J, Yokoi H, Kozuma K, Tanabe K, Akasaka T, Shinke T, Ueno T, Hirayama A, Uemura S, Kuroda T, Takita A, Harada A, Iijima R, Murakami Y, Saito S, Nakamura M

Heart Vessels 2022年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Protective Roles of Xenotropic and Polytropic Retrovirus Receptor 1 (XPR1) in Uremic Vascular Calcification. 査読国際誌

Arase H, Yamada S, Torisu K, Tokumoto M, Taniguchi M, Tsuruya K, Nakano T, Kitazono T

Calcif Tissue Int 2022年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Delayed administration of epinephrine is associated with worse neurological outcomes in patients with out-of-hospital cardiac arrest and initial pulseless electrical activity: insight from the nationwide multicentre observational JAAM-OHCA (Japan Association for Acute Medicine) registry 査読国際誌

Enzan N, Hiasa KI, Ichimura K, Nishihara M, Iyonaga T, Shono Y, Tohyama T, Funakoshi K, Kitazono T, Tsutsui H

Eur Heart J Acute Cardiovasc Care 2022年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Relationship of coffee consumption with a decline in kidney function among patients with type 2 diabetes: The Fukuoka Diabetes Registry 査読国際誌

Komorita Y, Ohkuma T, Iwase M, Fujii H, Ide H, Oku Y, Higashi T, Oshiro A, Sakamoto W, Yoshinari M, Nakamura U, Kitazono T

J Diabetes Investig 2022年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association Between Diabetes and Gray Matter Atrophy Patterns in a General Older Japanese Population: The Hisayama Study 査読国際誌

Hirabayashi N, Hata J, Furuta Y, Ohara T, Shibata M, Hirakawa Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Ninomiya T

Diabetes Care 2022年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Serum Alkaline Phosphatase Levels and Increased Risk of Brain Hemorrhage in Hemodialysis Patients: The Q-Cohort Study 査読国際誌

Kitamura H, Yamada S, Hiyamuta H, Yotsueda R, Taniguchi M, Tokumoto M, Tsuruya K, Nakano T, Kitazono T

J Atheroscler Thromb 2022年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Relationship between platelet aggregation and stroke risk after percutaneous coronary intervention: a PENDULUM analysis 査読国際誌

Matsumaru Y, Kitazono T, Kadota K, Nakao K, Nakagawa Y, Shite J, Yokoi H, Kozuma K, Tanabe K, Akasaka T, Shinke T, Ueno T, Hirayama A, Uemura S, Kuroda T, Takita A, Harada A, Iijima R, Murakami Y, Saito S, Nakamura M

Heart Vessels 2022年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of Inner Retinal Thickness with Prevalent Dementia and Brain Atrophy in a General Older Population

Ueda, E; Hirabayashi, N; Ohara, T; Hata, J; Honda, T; Fujiwara, K; Furuta, Y; Shibata, M; Hashimoto, S; Nakamura, S; Nakazawa, T; Nakao, T; Kitazono, T; Ninomiya, T; Sonoda, KH

OPHTHALMOLOGY SCIENCE 2 ( 2 ) 100157 2022年6月（ ISSN:2666-9145 ）

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記述言語：英語出版者・発行元：Ophthalmology Science

Purpose: To assess the association of inner retinal thickness with prevalent dementia and regional brain atrophy in a general older population of Japanese. Design: Population-based, cross-sectional study. Participants: A total of 1078 residents aged 65 years or older who participated in an eye examination, a comprehensive survey of dementia, and brain magnetic resonance imaging scanning in 2017. Methods: The thicknesses of the inner retinal layers, namely, the ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL)—were measured by swept-source OCT (SS-OCT). The association of these retinal thicknesses with the risk of the presence of dementia was estimated using restricted cubic splines and logistic regression models. Regional brain volumes were estimated separately by applying 2 different methods: voxel-based morphometry (VBM) and analysis by FreeSurfer software. The associations of GC-IPL and RNFL thickness with each brain regional volume were analyzed using multiple regression analysis. Main Outcome Measure: Prevalent dementia and regional brain atrophy. Results: Among the study participants, 61 participants (5.7%) were diagnosed with dementia. The likelihood of the presence of dementia significantly increased with lower GC-IPL thickness after adjusting for potential confounders (odds ratio, 1.62 [95% confidence interval, 1.30–2.01] per 1 standard deviation decrement in the GC-IPL thickness), but no significant association was observed with RNFL thickness. In the VBM analyses with the multivariable adjustment, lower GC-IPL thickness was significantly associated with lower volume of known brain regions related to cognitive functions (i.e., the hippocampus, amygdala, entorhinal area, and parahippocampal gyrus) and visual functions (i.e., the cuneus, lingual gyrus, and thalamus). Meanwhile, the volume of the thalamus significantly decreased with lower RNFL thickness, but none of the brain regions related to cognitive function exhibited a volume change in association with RNFL thickness. The sensitivity analysis using FreeSurfer analysis also showed that lower GC-IPL thickness was significantly associated with lower regional brain volume/intracranial volume of the hippocampus, amygdala, cuneus, lingual gyrus, and thalamus. Conclusions: Our findings suggest that the measurement of GC-IPL thickness by SS-OCT, which is a noninvasive, convenient, and reproducible method, might be useful for identifying high-risk individuals with dementia.

DOI： 10.1016/j.xops.2022.100157

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PubMed
Association Between Diabetes and Gray Matter Atrophy Patterns in a General Older Japanese Population: The Hisayama Study

Hirabayashi, N; Hata, J; Furuta, Y; Ohara, T; Shibata, M; Hirakawa, Y; Yamashita, F; Yoshihara, K; Kitazono, T; Sudo, N; Ninomiya, T

DIABETES CARE 45 ( 6 ) 1364 - 1371 2022年6月（ ISSN:0149-5992 eISSN:1935-5548 ）

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記述言語：英語出版者・発行元：Diabetes Care

OBJECTIVE To examine the association between diabetes and gray matter atrophy patterns in a general older Japanese population. RESEARCH DESIGN AND METHODS In 2012, a total of 1,189 community-dwelling Japanese aged ≥65 years underwent brain MRI scans. Regional gray matter volumes (GMV) and intracranial volume (ICV) were measured by applying voxel-based morphometry (VBM) methods. The associations of diabetes and related parameters with the regional GMV/ICV were examined using an ANCOVA. The regional gray matter atrophy patterns in the subjects with diabetes or elevated fasting plasma glucose (FPG) or 2-h postload glucose (2hPG) levels were investigated using VBM. RESULTS Subjects with diabetes had significantly lower mean values of GMV/ICV in the frontal lobe, temporal lobe, insula, deep gray matter structures, and cerebellum than subjects without diabetes after adjusting for potential confounders. A longer duration of diabetes was also significantly associated with lower mean values of GMV/ICV in these brain regions. The multivariable-adjusted mean values of the temporal, insular, and deep GMV/ICV decreased significantly with elevating 2hPG levels, whereas higher FPG levels were not significantly associated with GMV/ICV of any brain regions. In the VBM analysis, diabetes was associated with gray matter atrophy in the bilateral superior temporal gyri, right middle temporal gyrus, left inferior temporal gyrus, right middle frontal gyrus, bilateral thalami, right caudate, and right cerebellum. CONCLUSIONS The current study suggests that a longer duration of diabetes and elevated 2hPG levels are significant risk factors for gray matter atrophy in various brain regions.

DOI： 10.2337/dc21-1911

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PubMed
2型糖尿病患者におけるコーヒー摂取と腎機能低下との関連　Fukuoka Diabetes Registry(Relationship of coffee consumption with a decline in kidney function among patients with type 2 diabetes: The Fukuoka Diabetes Registry)

Komorita Yuji, Ohkuma Toshiaki, Iwase Masanori, Fujii Hiroki, Ide Hitoshi, Oku Yutaro, Higashi Taiki, Oshiro Ayaka, Sakamoto Wakako, Yoshinari Masahito, Nakamura Udai, Kitazono Takanari

Journal of Diabetes Investigation 13 ( 6 ) 1030 - 1038 2022年6月（ ISSN:2040-1116 ）

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記述言語：英語出版者・発行元：John Wiley & Sons Australia, Ltd

Fukuoka Diabetes Registryに登録された2型糖尿病患者3805例(男性2112例、平均64.2歳、eGFR>60mL/min/1.73m2)を対象とした前向き研究を実施し、コーヒー摂取と推定糸球体機能率(eGFR)低下との関連について検討した。ベースラインでのコーヒー摂取頻度(全く飲まない、1日1杯未満、1日1杯、1日2杯以上)を評価した。エンドポイントは追跡期間中におけるeGFR<60mL/min/1.73m2への低下とした。追跡期間中央値は5.3年、追跡完遂率は97.6%であった。その結果、追跡期間中に840例でeGFR低下が認められた。コーヒー摂取量が高いほど、eGFR低下リスクは減少していた。コーヒーを摂取しない場合と比較した結果、コーヒー摂取頻度1日1杯未満、1日1杯、1日2杯以上の多変量調整ハザード比は0.77、0.77、0.75であった(P for trend 0.01)。この傾向は、ベースラインのeGFRおよびアルブミン尿などの潜在的交絡因子調整後も維持された。1年あたりのeGFR平均変化量はコーヒー摂取なし、1日1杯未満、1日1杯、1日2杯以上でそれぞれ-2.16mL/min/1.73m2、-1.89mL/min/1.73m2、-1.80mL/min/1.73m2、-1.78mL/min/1.73m2であった(P for trend 0.03)。以上から、2型糖尿病患者におけるコーヒー摂取はeGFR低下リスクを有意に低下させることが示された。
Practical "1-2-3-4-Day" Rule for Starting Direct Oral Anticoagulants After Ischemic Stroke With Atrial Fibrillation: Combined Hospital-Based Cohort Study 査読国際誌

Stroke 2022年5月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Comparison of the predictability of serum creatinine-based surrogates of skeletal muscle mass for all-cause mortality in patients receiving hemodialysis: creatinine generation rate and creatinine index 査読国際誌

Yamada S, Arase H, Taniguchi M, Kitazono T, Nakano T

Clin Exp Nephrol 2022年5月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
The Compositional Structure of the Small Intestinal Microbial Community via Balloon-Assisted Enteroscopy 査読国際誌

Nagasue T, Hirano A, Torisu T, Umeno J, Shibata H, Moriyama T, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Esaki M, Kitazono T.

Digestion 2022年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Usefulness of urinary tubule injury markers for predicting progression of renal dysfunction in patients with type 2 diabetes and albuminuria: The Fukuoka Diabetes Registry 査読国際誌

Ide H, Iwase M, Ohkuma T, Fujii H, Komorita Y, Oku Y, Higashi T, Yoshinari M, Nakamura U, Kitazono T

Diabetes Res Clin Pract 2022年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of Inner Retinal Thickness with Prevalent Dementia and Brain Atrophy in a General Older Population: The Hisayama Study 査読国際誌

Ueda E, Hirabayashi N, Ohara T, Hata J, Honda T, Fujiwara K, Furuta Y, Shibata M, Hashimoto S, Nakamura S, Nakazawa T, Nakao T, Kitazono T, Ninomiya T, Sonoda KH

Ophthalmol Sci 2022年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
One-year clinical efficacy and safety of indigo naturalis for active ulcerative colitis: a real-world prospective study 査読国際誌

Matsuno Y, Torisu T, Umeno J, Shibata H, Hirano A, Fuyuno Y, Okamoto Y, Fujioka S, Kawasaki K, Moriyama T, Nagasue T, Zeze K, Hirakawa Y, Kawatoko S, Koga Y, Oda Y, Esaki M, Kitazono T

Intest Res 2022年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of daily sleep duration with the incident dementia by serum soluble TREM2 in a community 査読国際誌

Ohara T, Hata J, Tanaka M, Honda T, Yamakage H, Inoue T, Hirakawa Y, Kusakabe T, Shibata M, Kitazono T, Nakao T, Satoh-Asahara N, Ninomiya T

J Am Geriatr Soc 2022年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of daily sleep duration with the incident dementia by serum soluble TREM2 in a community

Ohara, T; Hata, J; Tanaka, M; Honda, T; Yamakage, H; Inoue, T; Hirakawa, Y; Kusakabe, T; Shibata, M; Kitazono, T; Nakao, T; Satoh-Asahara, N; Ninomiya, T

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 70 ( 4 ) 1147 - 1156 2022年4月（ ISSN:0002-8614 eISSN:1532-5415 ）

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記述言語：英語出版者・発行元：Journal of the American Geriatrics Society

Background: Little is known about the influence of serum level of soluble triggering receptor expressed on myeloid cells 2 (sTREM2), which is a soluble type of an innate immune receptor expressed on the microglia, on the association of the daily sleep duration with the risk of dementia. Methods: A total of 1230 Japanese community-residents aged 60 and older without dementia were followed prospectively for 10 years (2002–2012). Serum sTREM2 levels were divided into two groups using the median value (334.8 pg/ml). Self-reported daily sleep duration was grouped into three categories of <5.0, 5.0–7.9, and ≥8.0 h. A Cox proportional hazards model was used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) of daily sleep duration on the risk of dementia according to serum sTREM2 levels. Results: During the follow-up, 262 subjects developed dementia. In subjects with low serum sTREM2 levels, subjects with ≥8.0 h of daily sleep had a significantly greater risk of dementia (multivariable-adjusted HR 2.05 [95% CI 1.32–3.19]) than those with 5.0–7.9 h of daily sleep, but those with <5.0 h did not. In contrast, the risk of dementia increased significantly in subjects with both <5.0 (1.95 [1.03–3.68]) and ≥8.0 h of daily sleep (1.48 [1.06–2.07]) in the subjects with high serum sTREM2 levels. Conclusions: The influence of daily sleep duration on risk of dementia differed according to serum sTREM2 levels in the older Japanese population. Short daily sleep may be associated with greater risk of dementia only in subjects with a high serum sTREM2 level.

DOI： 10.1111/jgs.17634

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PubMed
Multiple-region grey matter atrophy as a predictor for the development of dementia in a community: the Hisayama Study. 査読国際誌

Nakazawa T, Ohara T, Hirabayashi N, Furuta Y, Hata J, Shibata M, Honda T, Kitazono T, Nakao T, Ninomiya T

J Neurol Neurosurg Psychiatry 2022年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Long-term association of vegetable and fruit intake with risk of dementia in Japanese older adults: the Hisayama study 査読国際誌

Kimura Y, Yoshida D, Ohara T, Hata J, Honda T, Hirakawa Y, Shibata M, Oishi E, Sakata S, Furuta Y, Chen S, Uchida K, Nakao T, Kitazono T, Ninomiya T

BMC Geriatr 2022年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Impact of three major risk factors on clinical outcomes in patients with nonvalvular atrial fibrillation receiving rivaroxaban: Sub-analysis from the XAPASS study 査読国際誌

Ikeda T, Ogawa S, Kitazono T, Nakagawara J, Minematsu K, Miyamoto S, Murakawa Y, Tachiiri M, Okayama Y, Sunaya T, Hirano K, Hayasaki T

J Arrhythm 2022年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Changes in Body Weight and Concurrent Changes in Cardiovascular Risk Profiles in Community Residents in Japan: the Hisayama Study

Honda, T; Ishida, Y; Oda, M; Noguchi, K; Chen, SM; Sakata, S; Oishi, E; Furuta, Y; Yoshida, D; Hirakawa, Y; Hata, J; Kitazono, T; Ninomiya, T

Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 29 ( 2 ) 252 - 267 2022年2月（ ISSN:13403478 eISSN:18803873 ）

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記述言語：英語出版者・発行元：一般社団法人日本動脈硬化学会

Aim: We investigated the influence of weight change on concurrent changes in predicted cardiovascular disease (CVD) risk and individual CVD risk factors over time. Methods: A total of 2,140 community-dwellers aged 40–74 years participated in both 2002 and 2007 health examinations. Obesity was defined as body mass index ≥ 25 kg/m2. Weight trajectories were classified as: “stable obese” (obese at both examinations), “obese to nonobese” (obese in 2002 but nonobese in 2007), “nonobese to obese” (nonobese in 2002 but obese in 2007), or “stable nonobese” (nonobese at both examinations). We compared changes in the model-predicted risk for CVD and individual CVD risk factors across weight-change categories. Results: The predicted risk for CVD increased during 5 years in all groups; the increment in the predicted risk for CVD was smallest in the obese to nonobese participants and steepest in the nonobese to obese subjects. Compared with the stable obese participants, the obese to nonobese participants had greater favorable changes in waist circumferences, blood pressure, fasting plasma glucose, serum high-density lipoprotein cholesterol, serum triglycerides, and liver enzymes. For all these parameters, opposite trends were observed when comparing the nonobese to obese participants with the stable nonobese group. Conclusions: We demonstrated the favorable association of losing weight in obese people and avoiding excessive weight gain in nonobese people with global risk of future CVD and individual CVD risk factors in a real-world setting. The findings could improve behavioral lifestyle interventions that provide information on the health consequences of weight change at health checkups.

DOI： 10.5551/jat.59394

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CiNii Research
Development and Validation of a Risk Prediction Model for Atherosclerotic Cardiovascular Disease in Japanese Adults: The Hisayama Study. 査読国際誌

Honda T, Chen S, Hata J, Yoshida D, Hirakawa Y, Furuta Y, Shibata M, Sakata S, Kitazono T, Ninomiya T

J Atheroscler Thromb 2022年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Serum Uric Acid Levels and Nephrosclerosis in a Population-Based Autopsy Study: The Hisayama Study. 査読国際誌

Maki K, Hata J, Sakata S, Oishi E, Furuta Y, Nakano T, Oda Y, Kitazono T, Ninomiya T

Am J Nephrol 2022年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Long-Term Trends in The 5-Year Risk of Recurrent Stroke over A Half Century in A Japanese Community: The Hisayama Study 査読国際誌

Nakanishi Y, Furuta Y, Hata J, Yubi T, Oishi E, Sakata S, Hirakawa Y, Wakisaka Y, Ago T, Kitazono T, Ninomiya T

J Atheroscler Thromb 2022年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Intravenous Alteplase at 0.6 mg/kg for Unknown Onset Stroke with Prior Antithrombotic Medication: THAWS Randomized Clinical Trial 査読国際誌

Koga M, Inoue M, Miwa K, Yoshimura S, Fukuda-Doi M, Aoki J, Asakura K, Kanzawa T, Ohtaki M, Kamiyama K, Yakushiji Y, Igarashi S, Doijiri R, Ito Y, Takagi Y, Sasaki M, Kitazono T, Kimura K, Minematsu K, Yamamoto H, Toyoda K; THAWS trial investigators

J Atheroscler Thromb 2022年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Lymphoid and myeloid proliferative disorders associated with inflammatory bowel disease: a clinicopathological study of 15 cases 査読国際誌

Hori Y, Yamamoto H, Kawatoko S, Nozaki Y, Torisu T, Kato K, Koga Y, Miyoshi H, Ohshima K, Tateishi Y, Nakamura S, Kitazono T, Oda Y

Hum Pathol 2022年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016 査読国際誌

Kurogi A, Onozuka D, Hagihara A, Nishimura K, Kada A, Hasegawa M, Higashi T, Kitazono T, Ohta T, Sakai N, Arai H, Miyamoto S, Sakamoto T, Iihara K; J-ASPECT Study Collaborators

Sci Rep 2022年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Incidence of end-stage renal disease and risk factors for progression of renal dysfunction in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry . 査読国際誌

Iwase M, Ide H, Ohkuma T, Fujii H, Komorita Y, Yoshinari M, Oku Y, Higashi T, Nakamura U, Kitazono T

Clin Exp Nephrol 2022年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Changes in Body Weight and Concurrent Changes in Cardiovascular Risk Profiles in Community Residents in Japan: the Hisayama Study. 査読国際誌

Honda T, Ishida Y, Oda M, Noguchi K, Chen S, Sakata S, Oishi E, Furuta Y, Yoshida D, Hirakawa Y, Hata J, Kitazono T, Ninomiya T

J Atheroscler Thromb 2022年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
2型糖尿病の日本人患者における末期腎臓病の発生率と腎機能障害進行の危険因子　福岡県糖尿病患者データベース研究(Incidence of end-stage renal disease and risk factors for progression of renal dysfunction in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry)

Iwase Masanori, Ide Hitoshi, Ohkuma Toshiaki, Fujii Hiroki, Komorita Yuji, Yoshinari Masahito, Oku Yutaro, Higashi Taiki, Nakamura Udai, Kitazono Takanari

Clinical and Experimental Nephrology 26 ( 2 ) 122 - 131 2022年2月（ ISSN:1342-1751 ）

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記述言語：英語出版者・発行元：(一社)日本腎臓学会

2型糖尿病罹患の日本人集団での末期腎臓病の発生率と腎機能障害進行の危険因子を前向きに追跡調査した。2008年4月～2010年10月に多施設共同前向き研究(福岡県糖尿病患者データベース研究;Fukuoka Diabetes Registry)へ登録された2型糖尿病の外来成人患者で、少なくとも初年度は追跡できた4904名(男性57%、平均65±10歳)を本研究に組み入れた。末期腎臓病の発生率は4.1/1000人-年、全死因死亡率は12.3/1000人-年であった。推算糸球体濾過量(eGFR)が30mL/分/1.73m2の集団に限定すると、上記の両率は同順で176.6/1000人-年および57.4/1000人-年といずれも上昇した。ベースラインから5年後までにeGFRの減少率が30%を上回った患者の割合は16.4%であり、eGFRの平均年次減少率は1.84mL/分/1.73m2/年であった。腎機能障害の進行と有意に関連していた因子は、高齢、血糖コントロール不良、血圧、アルブミン尿、eGFR、心血管疾患の既往、ライフスタイル要因(BMI、食物繊維摂取不足、ナトリウム摂取増加、定期的な運動習慣の欠如)、抑うつ症状であった。本前向き研究の結果から、日本人2型糖尿病患者で高かった末期腎臓病の発生率を抑制するには、様々な危険因子に対する多面的介入が重要であることが強調された。
Association of the nutritional risk index for Japanese hemodialysis patients with long-term mortality: The Q-Cohort Study. 査読国際誌

Shimamoto S, Yamada S, Hiyamuta H, Arase H, Taniguchi M, Tsuruya K, Nakano T, Kitazono T

Clin Exp Nephrol 2022年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Malnutrition-Inflammation Complex Syndrome and Bone Fractures and Cardiovascular Disease Events in Patients Undergoing Hemodialysis: The Q-Cohort Study 査読国際誌

Yamada S, Arase H, Yoshida H, Kitamura H, Tokumoto M, Taniguchi M, Hirakata H, Tsuruya K, Nakano T, Kitazono T

Kidney Med 2022年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Day-by-Day Blood Pressure Variability in the Subacute Stage of Ischemic Stroke and Long-Term Recurrence 査読国際誌

Fukuda K, Matsuo R, Kamouchi M, Kiyuna F, Sato N, Nakamura K, Hata J, Wakisaka Y, Ago T, Imaizumi T, Kai H, Kitazono T; FSR Investigators

Stroke 2022年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Sex differences in the 10-year survival of patients undergoing maintenance hemodialysis in the Q-Cohort Study. 査読国際誌

Tsujikawa H, Yamada S, Hiyamuta H, Taniguchi M, Tsuruya K, Torisu K, Nakano T, Kitazono T

Sci Rep 2022年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Twenty-Year Change in Severity and Outcome of Ischemic and Hemorrhagic Strokes. 査読国際誌

Toyoda K, Yoshimura S, Nakai M, Koga M, Sasahara Y, Sonoda K, Kamiyama K, Yazawa Y, Kawada S, Sasaki M, Terasaki T, Miwa K, Koge J, Ishigami A, Wada S, Iwanaga Y, Miyamoto Y, Minematsu K, Kobayashi S; Japan Stroke Data Bank Investigators (Kitazono T)

JAMA Neurol 2022年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of the nutritional risk index for Japanese hemodialysis patients with long-term mortality: The Q-Cohort Study

Shimamoto, S; Yamada, S; Hiyamuta, H; Arase, H; Taniguchi, M; Tsuruya, K; Nakano, T; Kitazono, T

CLINICAL AND EXPERIMENTAL NEPHROLOGY 26 ( 1 ) 59 - 67 2022年1月（ ISSN:1342-1751 eISSN:1437-7799 ）

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記述言語：英語出版者・発行元：Clinical and Experimental Nephrology

Background: Protein-energy wasting (PEW) is a risk factor for mortality in patients undergoing hemodialysis. Recently, a nutritional risk index for Japanese hemodialysis patients (NRI-JH) has been proposed as a surrogate index of PEW. However, no study has determined the association of the NRI-JH with long-term mortality in patients undergoing hemodialysis. Furthermore, the validity of the NRI-JH has not been confirmed. Methods: In total, 3046 patients undergoing hemodialysis and registered in the Q-Cohort Study were followed up for 10 years. The NRI-JH was calculated on the basis of body mass index and serum levels of albumin, total cholesterol, and creatinine. The patients were divided into four groups according to the NRI-JH scores: 0–3 (G1, n = 1343), 4–7 (G2, n = 1136), 8–10 (G3, n = 321), and 11–13 (G4, n = 246). We examined the association between the NRI-JH and the 4-year and 10-year risks of all-cause, cardiovascular, and infection-related deaths using the Cox proportional hazards model. Results: During the follow-up period, 647 patients died during the first 4 years, and 1503 patients died within 10 years. The 4-year prognosis was analyzed and compared with the lowest NRI-JH score group. Multivariable-adjusted hazard ratios (95% confidence intervals) for all-cause death were 1.93 (1.57–2.38), 2.68 (2.05–3.50), and 3.16 (2.40–4.16) in the G2, G3, and G4 groups, respectively. Similarly, a higher NRI-JH score was associated with an increased risk of cardiovascular and infection-related deaths. Conclusion: A higher NRI-JH score was associated with an increased risk of long-term mortality in patients undergoing maintenance hemodialysis. Trial registration: The study protocol was registered in the University Hospital Medical Information Network (UMIN) clinical trial registry (UMIN ID: 000000556).

DOI： 10.1007/s10157-021-02124-6

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PubMed
Risk of Rebleeding in Patients with Small Bowel Vascular Lesions. 査読国際誌

Harada A, Torisu T, Fujioka S, Yoshida Y, Okamoto Y, Fuyuno Y, Hirano A, Umeno J, Torisu K, Moriyama T, Esaki M, Kitazono T

Intern Med 2021年12月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Sex Differences in the Risk of 30-Day Death After Acute Ischemic Stroke. 査読国際誌

Irie F, Matsuo R, Nakamura K, Wakisaka Y, Ago T, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators

Neurol Clin Pract 2021年12月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Constipation and diabetic kidney disease: The Fukuoka Diabetes Registry. 査読国際誌

Ohkuma T, Iwase M, Fujii H, Ide H, Komorita Y, Yoshinari M, Oku Y, Higashi T, Oshiro A, Nakamura U, Kitazono T.

Clin Exp Nephrol 2021年11月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association between the urinary sodium-to-potassium ratio and renal outcomes in patients with chronic kidney disease: a prospective cohort study. 査読国際誌

Matsukuma Y, Nakayama M, Tsuda S, Fukui A, Yoshitomi R, Tsuruya K, Nakano T, Kitazono T

Hypertens Res 2021年11月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Polypharmacy and bone fracture risk in patients with type 2 diabetes: The Fukuoka Diabetes Registry. 査読国際誌

Komorita Y, Ohkuma T, Iwase M, Fujii H, Oku Y, Higashi T, Oshiro A, Sakamoto W, Yoshinari M, Nakamura U, Kitazono T

Diabetes Res Clin Pract 2021年11月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Left Atrial Appendage Flow Velocity and Multiple Infarcts in Cryptogenic Stroke. 査読国際誌

Tokunaga K, Hashimoto G, Mizoguchi T, Mori K, Shijo M, Jinnouchi J, Kuwashiro T, Yasaka M, Kitazono T, Okada Y

Cerebrovasc Dis 2021年11月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Autophagy gene ATG7 regulates albumin transcytosis in renal tubule epithelial cells. 査読国際誌

Uchida Y, Torisu K, Ueki K, Tsuruya K, Nakano T, Kitazono T

Am J Physiol Renal Physiol 2021年11月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association between Multimorbidity and Kidney Function among Patients with Non-Dialysis-Dependent CKD. 査読国際誌

Tanaka S, Nakano T, Hiyamuta H, Tsuruya K, Kitazono T; FKR Study Collaboration Group

J Atheroscler Thromb 2021年10月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Midlife and late-life diabetes and sarcopenia in a general older Japanese population: The Hisayama Study. 査読国際誌

Nakamura K, Yoshida D, Honda T, Hata J, Shibata M, Hirakawa Y, Furuta Y, Kishimoto H, Ohara T, Chen S, Kitazono T, Nakashima Y, Ninomiya T

J Diabetes Investig 2021年10月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Associations Between Surrogates of Skeletal Muscle Mass and History of Bone Fracture in Patients with Chronic Kidney Disease: The Fukuoka Kidney disease Registry (FKR) Study. 査読国際誌

Yamada S, Tanaka S, Arase H, Hiyamuta H, Yoshizumi E, Tokumoto M, Nakano T, Tsuruya K, Kitazono T

Calcif Tissue Int 2021年10月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Regional Disparity of Reperfusion Therapy for Acute Ischemic Stroke in Japan: A Retrospective Analysis of Nationwide Claims Data from 2010 to 2015. 査読国際誌

Maeda M, Fukuda H, Matsuo R, Ago T, Kitazono T, Kamouchi M

J Am Heart Assoc 2021年10月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Causes of death in patients undergoing maintenance hemodialysis in Japan: 10-year outcomes of the Q-Cohort Study. 査読国際誌

Hiyamuta H, Yamada S, Taniguchi M, Nakano T, Tsuruya K, Kitazono T

Clin Exp Nephrol 2021年10月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Gastric microbiota in patients with Helicobacter pylori-negative gastric MALT lymphoma. 査読国際誌

Tanaka T, Matsuno Y, Torisu T, Shibata H, Hirano A, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Moriyama T, Esaki M, Kitazono T

Medicine (Baltimore) 2021年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Intraplaque high-intensity signal on time-of-flight magnetic resonance angiography and restenosis after carotid artery stenting. 査読国際誌

Tokunaga K, Tokunaga S, Hara K, Yasaka M, Okada Y, Kitazono T, Tsumoto T

J Neurosurg 2021年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Serum NT-proBNP levels and histopathological myocardial fibrosis in autopsied cases from a Japanese community: The Hisayama Study. 査読国際誌

Sasaki T, Izumaru K, Hata J, Sakata S, Oishi E, Nagata T, Tsuboi N, Oda Y, Kitazono T, Yokoo T, Ninomiya T

J Cardiol 2021年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Development of a risk prediction model for incident hypertension in Japanese individuals: the Hisayama Study. 査読国際誌

Oishi E, Hata J, Honda T, Sakata S, Chen S, Hirakawa Y, Yoshida D, Shibata M, Ohara T, Furuta Y, Kitazono T, Ninomiya T

Hypertens Res 2021年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Ischemic stroke, hemorrhage, and mortality in patients with non-valvular atrial fibrillation and renal dysfunction treated with rivaroxaban: sub-analysis of the EXPAND study 査読国際誌

Atarashi H, Uchiyama S, Inoue H, Kitazono T, Yamashita T, Shimizu W, Ikeda T, Kamouchi M, Kaikita K, Fukuda K, Origasa H, Shimokawa H

Heart Vessels 2021年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Adding Thiopurine After Loss of Response to Infliximab Versus Early Combination in Treating Crohn's Disease: A Retrospective Study. 査読国際誌

Zeze K, Hirano A, Torisu T, Esaki M, Moriyama T, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Kitazono T

Dig Dis Sci 2021年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Impact of Physician Volume and Specialty on In-Hospital Mortality of Ischemic and Hemorrhagic Stroke. 査読国際誌

Nishimura K, Ogasawara K, Kitazono T, Iihara K; J-ASPECT Study Collaborators

Circ J 2021年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
β-Cell Function and Clinical Outcome in Nondiabetic Patients With Acute Ischemic Stroke. 査読国際誌

2021年8月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Comparison of the contributions of impaired beta cell function and insulin resistance to the development of type 2 diabetes in a Japanese community: the Hisayama Study. 査読国際誌

Yoshinari M, Hirakawa Y, Hata J, Higashioka M, Honda T, Yoshida D, Mukai N, Nakamura U, Kitazono T, Ninomiya T

Diabetologia 2021年8月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Subclinical hypothyroidism is independently associated with poor renal outcomes in patients with chronic kidney disease. 査読国際誌

Tsuda S, Nakayama M, Matsukuma Y, Yoshitomi R, Haruyama N, Fukui A, Nakano T, Tsuruya K, Kitazono T

Endocrine 2021年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Serum High-Sensitivity C-Reactive Protein Levels and the Development of Atrial Fibrillation in a General Japanese Population - The Hisayama Study. 査読国際誌

Yoshikawa T, Hata J, Sakata S, Nagata T, Hirakawa Y, Hirooka Y, Tsutsui H, Kitazono T, Ninomiya T

Circ J 2021年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Risk Prediction Model for Incident Atrial Fibrillation in a General Japanese Population - The Hisayama Study. 査読国際誌

Hata J, Nagata T, Sakata S, Oishi E, Furuta Y, Hirakawa Y, Honda T, Yoshida D, Kitazono T, Ninomiya T

Circ J 2021年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of blood pressure after peritoneal dialysis initiation with the decline rate of residual kidney function in newly-initiated peritoneal dialysis patients. 査読国際誌

Kuroki Y, Hori K, Tsuruya K, Matsuo D, Mitsuiki K, Hirakata H, Nakano T, Kitazono T

PLoS One 2021年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Ustekinumab Improves Active Crohn's Disease by Suppressing the T Helper 17 Pathway. 査読国際誌

Ihara Y, Torisu T, Miyawaki K, Umeno J, Kawasaki K, Hirano A, Fujioka S, Fuyuno Y, Matsuno Y, Sugio T, Sasaki K, Moriyama T, Akashi K, Kitazono T

Digestion 2021年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Real-world safety and effectiveness of rivaroxaban using Japan-specific dosage during long-term follow-up in patients with atrial fibrillation: XAPASS. 査読国際誌

Ikeda T, Ogawa S, Kitazono T, Nakagawara J, Minematsu K, Miyamoto S, Murakawa Y, Iwashiro S, Okayama Y, Sunaya T, Hirano K, Hayasaki T

PLoS One 2021年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
High low-density lipoprotein cholesterol as an independent risk factor for coronary restenosis in hemodialysis patients undergoing percutaneous coronary interventions. 査読国際誌

Hasegawa S, Nakano T, Mukai Y, Matsukuma Y, Yotsueda R, Tsuchimoto A, Fujisaki K, Tsuruya K, Tsutsui H, Kitazono T

Ther Apher Dial. 2021年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Prevalence and Mortality of Sarcopenia in a Community-dwelling Older Japanese Population: The Hisayama Study. 査読国際誌

Nakamura K, Yoshida D, Honda T, Hata J, Shibata M, Hirakawa Y, Furuta Y, Kishimoto H, Ohara T, Kitazono T, Nakashima Y, Ninomiya T

J Epidemiol 2021年5月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Current status of the certification of long-term care insurance among individuals with dementia in a Japanese community: The Hisayama Study. 査読国際誌

Ohara T, Yoshida D, Hata J, Shibata M, Honda T, Furuta Y, Hirabayashi N, Kitazono T, Nakao T, Ninomiya T

Psychiatry Clin Neurosci 2021年5月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Relationship between casual serum triglyceride levels and the development of hypertension in Japanese. 査読国際誌

Tomita Y, Sakata S, Arima H, Yamato I, Ibaraki A, Ohtsubo T, Matsumura K, Fukuhara M, Goto K, Kitazono T

J Hypertens 2021年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Urinary N-terminal pro-B-type natriuretic peptide as a biomarker for cardiovascular events in a general Japanese population: the Hisayama Study. 査読国際誌

Yamasaki K, Hata J, Ide T, Nagata T, Sakata S, Yoshida D, Honda T, Hirakawa Y, Nakano T, Kitazono T, Tsutsui H, Ninomiya T

Environ Health Prev Med 2021年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Dietary fiber intake and risk of type 2 diabetes in a general Japanese population: The Hisayama Study. 査読国際誌

Kimura Y, Yoshida D, Hirakawa Y, Hata J, Honda T, Shibata M, Sakata S, Uchida K, Kitazono T, Ninomiya T

J Diabetes Investig 2021年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Clopidogrel response predicts thromboembolic events associated with coil embolization of unruptured intracranial aneurysms: A prospective cohort study. 査読国際誌

Higashi E, Matsumoto S, Nakahara I, Hatano T, Ishii A, Sadamasa N, Ohta T, Ishihara T, Tokunaga K, Ando M, Chihara H, Furuta K, Hashimoto T, Tanaka K, Sonoda K, Koge J, Takita W, Hashikawa T, Funakoshi Y, Kondo D, Kamata T, Tsujimoto A, Matsushita T, Murai H, Matsuo K, Kitazono T, Kira J

PLoS One 2021年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Prevalence of bone fracture and its association with severe hypoglycemia in Japanese patients with type 1 diabetes. 査読国際誌

Komorita Y, Minami M, Maeda Y, Yoshioka R, Ohkuma T, Kitazono T

BMJ Open Diabetes Res Care 2021年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Relationship between serum lipid concentrations and impaired renal function in patients with chronic kidney disease: the Fukuoka Kidney Disease Registry Study. 査読国際誌

Nakano T, Tanaka S, Tsuruya K, Kitazono T

Clin Exp Nephrol 2021年4月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Pre-Stroke Cholinesterase Inhibitor Treatment Is Beneficially Associated with Functional Outcome in Patients with Acute Ischemic Stroke and Pre-Stroke Dementia: The Fukuoka Stroke Registry. 招待国際誌

Wakisaka Y, Matsuo R, Nakamura K, Ago T, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators

Cerebrovasc Dis 2021年4月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Impact of Multivascular Disease on Cardiovascular Mortality and Morbidity in Patients Receiving Hemodialysis: Ten-Year Outcomes of the Q-Cohort Study. 査読国際誌

Tanaka S, Nakano T, Hiyamuta H, Taniguchi M, Tokumoto M, Masutani K, Ooboshi H, Tsuruya K, Kitazono T

J Atheroscler Thromb 2021年4月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Stronger Effect of Azilsartan on Reduction of Proteinuria Compared to Candesartan in Patients with CKD: A Randomized Crossover Trial. 査読国際誌

Suehiro T, Tsuruya K, Yoshida H, Tsujikawa H, Yamada S, Tanaka S, Tsuchimoto A, Eriguchi M, Fujisaki K, Torisu K, Nakano T, Kitazono T

Kidney Blood Press Res 2021年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association between geriatric nutritional risk index and stroke risk in hemodialysis patients: 10-Years outcome of the Q-Cohort study. 査読国際誌

Tsuneyoshi S, Matsukuma Y, Kawai Y, Hiyamuta H, Yamada S, Kitamura H, Tanaka S, Taniguchi M, Tsuruya K, Nakano T, Kitazono T

Atherosclerosis 2021年4月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Blood Pressure Level and Variability During Long-Term Prasugrel or Clopidogrel Medication After Stroke: PRASTRO-I. 査読国際誌

Toyoda K, Yamagami H, Kitagawa K, Kitazono T, Nagao T, Minematsu K, Uchiyama S, Tanahashi N, Matsumoto M, Nagata I, Nishikawa M, Nanto S, Shirai T, Abe K, Ikeda Y, Ogawa A; PRASTRO Trial Investigators*

Stroke 2021年4月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of normalized protein catabolic rate (nPCR) with the risk of bone fracture in patients undergoing maintenance hemodialysis: The Q-Cohort Study. 査読国際誌

Ohnaka S, Yamada S, Tsujikawa H, Arase H, Taniguchi M, Tokumoto M, Tsuruya K, Nakano T, Kitazono T.

Clin Nutr. 2021年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of normalized protein catabolic rate (nPCR) with the risk of bone fracture in patients undergoing maintenance hemodialysis: The Q-Cohort Study. 査読国際誌

Ohnaka S, Yamada S, Tsujikawa H, Arase H, Taniguchi M, Tokumoto M, Tsuruya K, Nakano T, Kitazono T

Clin Nutr 2021年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association between coffee and green tea intake and pneumonia among the Japanese elderly: a case-control study. 査読国際誌

Kondo K, Suzuki K, Washio M, Ohfuji S, Adachi S, Kan S, Imai S, Yoshimura K, Miyashita N, Fujisawa N, Maeda A, Fukushima W, Hirota Y; Pneumonia in Elderly People Study Group

Sci Rep 2021年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
High Serum Folate Concentrations Are Associated with Decreased Risk of Mortality among Japanese Adults. 査読国際誌

Chen S, Honda T, Hata J, Sakata S, Furuta Y, Yoshida D, Shibata M, Ohara T, Hirakawa Y, Oishi E, Kitazono T, Ninomiya T

J Nutr 2021年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Efficacy and Safety of Prasugrel by Stroke Subtype: A Sub-Analysis of the PRASTRO-I Randomized Controlled Trial. 査読国際誌

Kitazono T, Toyoda K, Kitagawa K, Nagao T, Yamagami H, Uchiyama S, Tanahashi N, Matsumoto M, Minematsu K, Nagata I, Nishikawa M, Nanto S, Ikeda Y, Shirai T, Abe K, Ogawa A; PRASTRO-I Study Group.

Thromb. 2021年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Incidence of stroke and its association with glycemic control and lifestyle in Japanese patients with type 2 diabetes mellitus: The Fukuoka diabetes registry. 査読国際誌

Iwase M, Komorita Y, Ohkuma T, Fujii H, Ide H, Yoshinari M, Oku Y, Higashi T, Nakamura U, Kitazono T

Diabetes Res Clin Pract 2021年2月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Defecation frequency and glycemic control in patients with diabetes: The Fukuoka Diabetes Registry. 査読国際誌

Ohkuma T, Iwase M, Fujii H, Ide H, Komorita Y, Yoshinari M, Oku Y, Higashi T, Nakamura U, Kitazono T

J Diabetes Complications 2021年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Magnetic Resonance Imaging-Guided Thrombolysis (0.6 mg/kg) Was Beneficial for Unknown Onset Stroke Above a Certain Core Size: THAWS RCT Substudy 査読国際誌

Toyoda K, Inoue M, Yoshimura S, Yamagami H, Sasaki M, Fukuda-Doi M, Kimura K, Asakura K, Miwa K, Kanzawa T, Ihara M, Kondo R, Shiozawa M, Ohtaki M, Kamiyama K, Itabashi R, Iwama T, Aoki J, Minematsu K, Yamamoto H, Koga M; THAWS trial investigators*.(Kitazono T).

Stroke. 2021年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Day-by-Day Blood Pressure Variability in the Subacute Stage of Ischemic Stroke and Long-Term Recurrence. 査読国際誌

Fukuda K, Matsuo R, Kamouchi M, Kiyuna F, Sato N, Nakamura K, Hata J, Wakisaka Y, Ago T, Imaizumi T, Kai H, Kitazono T; FSR Investigators

Stroke 2021年1月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Association between urinary salt excretion and albuminuria in Japanese patients with chronic kidney disease: the Fukuoka kidney disease registry study. 査読国際誌

Fukui A, Nakayama M, Tanaka S, Matsukuma Y, Yoshitomi R, Nakano T, Tsuruya K, Kitazono T

Clin Exp Nephrol 2021年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
The Association of Small Dense Low-Density Lipoprotein Cholesterol and Coronary Heart Disease in Subjects at High Cardiovascular Risk. 査読国際誌

Higashioka M, Sakata S, Honda T, Hata J, Shibata M, Yoshida D, Goto K, Kitazono T, Osawa H, Ninomiya T

J Atheroscler Thromb 2021年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Development and validation of a risk score for the prediction of cardiovascular disease in living donor kidney transplant recipients. 査読国際誌

Ueki K, Tsuchimoto A, Matsukuma Y, Nakagawa K, Tsujikawa H, Masutani K, Tanaka S, Kaku K, Noguchi H, Okabe Y, Unagami K, Kakuta Y, Okumi M, Nakamura M, Tsuruya K, Nakano T, Tanabe K, Kitazono T; Japan Academic Consortium of Kidney Transplantation investigators

Nephrol Dial Transplant 2021年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Nationwide temporal trend analysis of reperfusion therapy utilization and mortality in acute ischemic stroke patients in Japan. 査読国際誌

Maeda M, Fukuda H, Matsuo R, Kiyuna F, Ago T, Kitazono T, Kamouchi M

Medicine (Baltimore) 2021年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
N-Terminal Pro-B-Type Natriuretic Peptide and Incident CKD. 査読国際誌

Sasaki T, Oishi E, Nagata T, Sakata S, Chen S, Furuta Y, Honda T, Yoshida D, Hata J, Tsuboi N, Kitazono T, Yokoo T, Ninomiya T

Kidney Int Rep 2021年1月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Measuring Quality of Care for Ischemic Stroke Treated With Acute Reperfusion Therapy in Japan - The Close The Gap-Stroke. 査読国際誌

Ren N, Nishimura A, Kurogi A, Nishimura K, Matsuo R, Ogasawara K, Hashimoto Y, Higashi T, Sakai N, Toyoda K, Shiokawa Y, Tominaga T, Miyachi S, Kada A, Abe K, Ono K, Matsumizu K, Arimura K, Kitazono T, Miyamoto S, Minematsu K, Iihara K

Circ J 2021年1月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of hyperphosphatemia with an increased risk of sudden death in patients on hemodialysis: Ten-year outcomes of the Q-Cohort Study. 査読国際誌

Hiyamuta H, Yamada S, Taniguchi M, Tokumoto M, Tsuruya K, Nakano T, Kitazono T

Atherosclerosis 2021年1月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Significance of revised criteria for chronic active T cell-mediated rejection in the 2017 Banff classification: Surveillance by 1-year protocol biopsies for kidney transplantation. 査読国際誌

Nakagawa K, Tsuchimoto A, Ueki K, Matsukuma Y, Okabe Y, Masutani K, Unagami K, Kakuta Y, Okumi M, Nakamura M, Nakano T, Tanabe K, Kitazono T; Japan Academic Consortium of Kidney Transplantation Investigators.

Am J Transplant. 2021年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Serum N-terminal pro-B-type natriuretic peptide as a predictor for future development of atrial fibrillation in a general population: the Hisayama Study. 査読国際誌

Nagata T, Hata J, Sakata S, Oishi E, Honda T, Furuta Y, Ohara T, Yoshida D, Hirakawa Y, Shibata M, Ide T, Kitazono T, Tsutsui H, Ninomiya T.

Int J Cardiol. 2020年12月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data. 査読国際誌

Thomalla G, Boutitie F, Ma H, Koga M, Ringleb P, Schwamm LH, Wu O, Bendszus M, Bladin CF, Campbell BCV, Cheng B, Churilov L, Ebinger M, Endres M, Fiebach JB, Fukuda-Doi M, Inoue M, Kleinig TJ, Latour LL, Lemmens R, Levi CR, Leys D, Miwa K, Molina CA, Muir KW, Nighoghossian N, Parsons MW, Pedraza S, Schellinger PD, Schwab S, Simonsen CZ, Song SS, Thijs V, Toni D, Hsu CY, Wahlgren N, Yamamoto H, Yassi N, Yoshimura S, Warach S, Hacke W, Toyoda K, Donnan GA, Davis SM, Gerloff C; Evaluation of unknown Onset Stroke thrombolysis trials (EOS) investigators. (Kitazono T)

Lancet. 2020年11月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Anticoagulation and Risk of Stroke Recurrence in Patients with Embolic Stroke of Undetermined Source Having No Potential Source of Embolism. 査読国際誌

Sato N, Matsuo R, Kiyuna F, Nakamura K, Hata J, Wakisaka Y, Ago T, Kamouchi M, Kitazono T; collab on behalf of the Fukuoka Stroke Registry Investigators.

Cerebrovasc Dis. 2020年11月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Comparison of Immunohistochemical Staining for Large T Antigen and Capsid Protein VP1 in BK Polyomavirus-Associated Nephropathy. 査読国際誌

Masutani K, Matsukuma Y, Tsuchimoto A, Okabe Y, Doi A, Kaku K, Nakamura M, Nakano T, Tsuruya K, Kitazono T.

Nephron. 2020年11月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Prasugrel for Japanese Patients With Ischemic Heart Disease in Long-Term Clinical Practice (PRASFIT-Practice II) - Final 2-Year Follow-up Results of a Postmarketing Observational Study. 査読国際誌

Nakamura M, Kitazono T, Kozuma K, Sekine T, Nakamura S, Shiosakai K, Tanabe A, Iizuka T.

Circ J. 2020年10月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Influence of the Accumulation of Unhealthy Eating Habits on Obesity in a General Japanese Population: The Hisayama Study. 査読国際誌

Ishida Y, Yoshida D, Honda T, Hirakawa Y, Shibata M, Sakata S, Furuta Y, Oishi E, Hata J, Kitazono T, Ninomiya T.

Nutrients. 2020年10月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Association between serum glycated albumin and risk of cardiovascular disease in a Japanese community: The Hisayama Study. 査読国際誌

Mihara A, Ohara T, Hata J, Honda T, Chen S, Sakata S, Oishi E, Hirakawa Y, Nakao T, Kitazono T, Ninomiya T.

Atherosclerosis. 2020年10月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Estimated plasma osmolarity and risk of end-stage kidney disease in patients with IgA nephropathy. 査読国際誌

Tanaka S, Nakano T, Tokumoto M, Masutani K, Tsuchimoto A, Ooboshi H, Kitazono T.

Clin Exp Nephrol. 2020年10月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Additive effects of green tea and coffee on all-cause mortality in patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry. 査読国際誌

Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Yoshinari M, Oku Y, Higashi T, Nakamura U, Kitazono T.

BMJ Open Diabetes Res Care. 2020年10月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Reciprocal Interaction Between Pericytes and Macrophage in Poststroke Tissue Repair and Functional Recovery. 査読国際誌

Shibahara T, Ago T, Tachibana M, Nakamura K, Yamanaka K, Kuroda J, Wakisaka Y, Kitazono T.

Stroke. 2020年10月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation. 査読国際誌

Okumura K, Akao M, Yoshida T, Kawata M, Okazaki O, Akashi S, Eshima K, Tanizawa K, Fukuzawa M, Hayashi T, Akishita M, Lip GYH, Yamashita T; ELDERCARE-AF Committees and Investigators. (Kitazono T)

N Engl J Med. 2020年10月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Arginase 2 is a mediator of ischemia-reperfusion injury in the kidney through regulation of nitrosative stress. 査読国際誌

Hara M, Torisu K, Tomita K, Kawai Y, Tsuruya K, Nakano T, Kitazono T.

Kidney Int. 2020年9月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Incidence of severe hypoglycemia and its association with serum adiponectin in Japanese patients with type 1 and insulin-treated type 2 diabetes: The Fukuoka Diabetes Registry. 査読国際誌

Iwase M, Komorita Y, Fujii H, Ohkuma T, Ide H, Yoshinari M, Oku Y, Higashi T, Nakamura U, Kitazono T.

J Diabetes Investig. 2020年9月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Adding Thiopurine After Loss of Response to Infliximab Versus Early Combination in Treating Crohn's Disease: A Retrospective Study. 査読国際誌

Zeze K, Hirano A, Torisu T, Esaki M, Moriyama T, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Kitazono T.

Dig Dis Sci. 2020年9月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia-reperfusion injury. 査読国際誌

Okahara A, Koga JI, Matoba T, Fujiwara M, Tokutome M, Ikeda G, Nakano K, Tachibana M, Ago T, Kitazono T, Tsutsui H, Egashira K.

Sci Rep. 2020年9月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Temporal trends and geographical disparities in comprehensive stroke centre capabilities in Japan from 2010 to 2018. 査読国際誌

Kurogi A, Nishimura A, Nishimura K, Kada A, Onozuka D, Hagihara A, Ogasawara K, Shiokawa Y, Kitazono T, Arimura K, Iihara K; J-ASPECT Study Collaborators.

BMJ Open. 2020年8月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Higher Cholesterol Level Predicts Cardiovascular Event and Inversely Associates With Mortality in Hemodialysis Patients: 10-Year Outcomes of the Q-Cohort Study. 査読国際誌

Nakano T, Hiyamuta H, Yotsueda R, Tanaka S, Taniguchi M, Tsuruya K, Kitazono T.

Ther Apher Dial. 2020年8月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Lifetime cumulative incidence of dementia in a community-dwelling elderly population in Japan. 査読国際誌

Yoshida D, Ohara T, Hata J, Shibata M, Hirakawa Y, Honda T, Furuta Y, Oishi E, Sakata S, Kanba S, Kitazono T, Ninomiya T.

Neurology. 2020年8月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Impact of body mass index on real-world outcomes of rivaroxaban treatment in Japanese patients with non-valvular atrial fibrillation. 査読国際誌

Murakawa Y, Ikeda T, Ogawa S, Kitazono T, Nakagawara J, Minematsu K, Miyamoto S, Hayashi Y, Kidani Y, Okayama Y, Sunaya T, Sato S, Yamanaka S.

Heart Vessels. 2020年8月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Small Dense Low-Density Lipoprotein Cholesterol and the Risk of Coronary Heart Disease in a Japanese Community. 査読国際誌

Higashioka M, Sakata S, Honda T, Hata J, Yoshida D, Hirakawa Y, Shibata M, Goto K, Kitazono T, Osawa H, Ninomiya T.

J Atheroscler Thromb. 2020年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Clinical experience of treating Graves' hyperthyroidism complicated with malignancy-The possible role of potassium iodide for avoiding the risk of thionamide-associated neutropenia. 査読国際誌

Okamura K, Bandai S, Fujikawa M, Sato K, Kitazono T.

Endocr J. 2020年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of serum phosphate concentration with the incidence of intervention for peripheral artery disease in patients undergoing hemodialysis: 10-year outcomes of the Q-Cohort Study. 査読国際誌

Shimamoto S, Yamada S, Hiyamuta H, Arase H, Taniguchi M, Tokumoto M, Nakano T, Tsuruya K, Kitazono T.

Atherosclerosis. 2020年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
30-minute postload plasma glucose levels during an oral glucose tolerance test predict the risk of future type 2 diabetes: the Hisayama Study. 査読国際誌

Hirakawa Y, Hata J, Yoshinari M, Higashioka M, Yoshida D, Shibata M, Honda T, Sakata S, Kato H, Teramoto T, Maki H, Nishimoto S, Kitazono T, Ninomiya T.

BMJ Open Diabetes Res Care. 2020年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Elevated serum glycated albumin and glycated albumin : hemoglobin A 1c ratio were associated with hippocampal atrophy in a general elderly population of Japanese: The Hisayama Study. 査読国際誌

Ohara T, Furuta Y, Hirabayashi N, Hata J, Hirakawa Y, Honda T, Yoshida D, Shibata M, Kitazono T, Ninomiya T.

J Diabetes Investig. 2020年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Prevalence and Mortality of Sarcopenia in a Community-dwelling Older Japanese Population: The Hisayama Study. 査読国際誌

Nakamura K, Yoshida D, Honda T, Hata J, Shibata M, Hirakawa Y, Furuta Y, Kishimoto H, Ohara T, Kitazono T, Nakashima Y, Ninomiya T.

J Epidemiol. 2020年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association Between Plasma Intact Parathyroid Hormone Levels and the Prevalence of Atrial Fibrillation in Patients With Chronic Kidney Disease - The Fukuoka Kidney Disease Registry Study. 査読国際誌

Arase H, Yamada S, Tanaka S, Tokumoto M, Tsuruya K, Nakano T, Kitazono T.

Circ J. 2020年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Utility of Columbia classification in focal segmental glomerulosclerosis: renal prognosis and treatment response among the pathological variants. 査読国際誌

Tsuchimoto A, Matsukuma Y, Ueki K, Tanaka S, Masutani K, Nakagawa K, Mitsuiki K, Uesugi N, Katafuchi R, Tsuruya K, Nakano T, Kitazono T.

Nephrol Dial Transplant. 2020年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Serum uric acid levels and cardiovascular mortality in a general Japanese population: the Hisayama Study. 査読国際誌

Sakata S, Hata J, Honda T, Hirakawa Y, Oishi E, Shibata M, Yoshida D, Goto K, Kitazono T, Ninomiya T.

Hypertens Res. 2020年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Thrombolysis With Alteplase at 0.6 mg/kg for Stroke With Unknown Time of Onset: A Randomized Controlled Trial. 招待査読国際誌

Koga M, Yamamoto H, Inoue M, Asakura K, Aoki J, Hamasaki T, Kanzawa T, Kondo R, Ohtaki M, Itabashi R, Kamiyama K, Iwama T, Nakase T, Yakushiji Y, Igarashi S, Nagakane Y, Takizawa S, Okada Y, Doijiri R, Tsujino A, Ito Y, Ohnishi H, Inoue T, Takagi Y, Hasegawa Y, Shiokawa Y, Sakai N, Osaki M, Uesaka Y, Yoshimura S, Urabe T, Ueda T, Ihara M, Kitazono T, Sasaki M, Oita A, Yoshimura S, Fukuda-Doi M, Miwa K, Kimura K, Minematsu K, Toyoda K; THAWS Trial Investigators.

Stroke. 2020年5月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Both hypo- and hyperglycaemia are associated with increased fracture risk in Japanese people with type 2 diabetes: the Fukuoka Diabetes Registry. 査読国際誌

Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Yoshinari M, Oku Y, Nakamura U, Kitazono T.

Diabet Med. 2020年5月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of aortic valve calcification with carotid artery lesions and peripheral artery disease in patients with chronic kidney disease: a cross-sectional study. 査読国際誌

Arita Y, Nakayama M, Matsukuma Y, Yoshitomi R, Seki M, Fukui A, Tsuda S, Sonoda Y, Imazu R, Arakawa K, Tominaga M, Nakano T, Tsuruya K, Kitazono T.

BMC Nephrol. 2020年5月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of Albuminuria With White Matter Hyperintensities Volume on Brain Magnetic Resonance Imaging in Elderly Japanese - The Hisayama Study. 査読国際誌

Yamasaki K, Hata J, Furuta Y, Hirabayashi N, Ohara T, Yoshida D, Hirakawa Y, Nakano T, Kitazono T, Ninomiya T.

Circ J. 2020年5月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
The Association between Dialysis Dose and Risk of Cancer Death in Patients Undergoing Hemodialysis: The Q-Cohort Study. 査読国際誌

Hara M, Tanaka S, Taniguchi M, Fujisaki K, Torisu K, Nakano T, Tsuruya K, Kitazono T.

Intern Med. 2020年5月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
The glucose degradation product methylglyoxal induces immature angiogenesis in patients undergoing peritoneal dialysis. 査読国際誌

Nakano T, Kumiko T, Mizumasa T, Kuroki Y, Tsuruya K, Kitazono T.

Biochem Biophys Res Commun. 2020年5月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Effect of treatment modality and cerebral vasospasm agent on patient outcomes after aneurysmal subarachnoid hemorrhage in the elderly aged 75 years and older. 査読国際誌

Ido K, Kurogi R, Kurogi A, Nishimura K, Arimura K, Nishimura A, Ren N, Kada A, Matsuo R, Onozuka D, Hagihara A, Takagishi S, Yamagami K, Takegami M, Nohara Y, Nakashima N, Kamouchi M, Date I, Kitazono T, Iihara K; J-ASPECT Study Collaborators.

PLos One. 2020年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Prevalence of bone fracture and its association with severe hypoglycemia in Japanese patients with type 1 diabetes. 招待査読国際誌

Komorita Y, Minami M, Maeda Y, Yoshioka R, Ohkuma T, Kitazono T

BMJ Open Diabetes Res Care 2020年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Effect of renin-angiotensin system blockade on graft survival and cardiovascular disease in kidney transplant recipients: retrospective multicenter study in Japan. 査読国際誌

Tsuchimoto A, Masutani K, Ueki K, Nakagawa K, Matsukuma Y, Tanaka S, Unagami K, Kakuta Y, Okumi M, Noguchi H, Kaku K, Okabe Y, Nakano T, Kitazono T, Nakamura M, Ishida H, Tanabe K; Japan Academic Consortium of Kidney Transplantation (JACK) Investigators.

Clin Exp Nephrol. 2020年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
The Incidence and Associated Factors of Sudden Death in Patients on Hemodialysis: 10-Year Outcome of the Q-Cohort Study. 査読国際誌

Hiyamuta H, Tanaka S, Taniguchi M, Tokumoto M, Fujisaki K, Nakano T, Tsuruya K, Kitazono T.

J Atheroscler Thromb. 2020年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of Lower Serum Bilirubin With Loss of Residual Kidney Function in Peritoneal Dialysis Patients. 査読国際誌

Tsujikawa H, Tanaka S, Hara M, Kawai Y, Matsukuma Y, Torisu K, Nakano T, Tsuruya K, Kitazono T.

Ther Apher Dial. 2020年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Increased Risk of Infection-Related and All-Cause Death in Hypercalcemic Patients Receiving Hemodialysis: The Q-Cohort Study. 査読国際誌

Yamada S, Arase H, Tokumoto M, Taniguchi M, Yoshida H, Nakano T, Tsuruya K, Kitazono T.

Sci Rep. 2020年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Mucosal dysbiosis in patients with gastrointestinal follicular lymphoma. 査読国際誌

Zeze K, Hirano A, Torisu T, Esaki M, Shibata H, Moriyama T, Umeno J, Fujioka S, Okamoto Y, Fuyuno Y, Matsuno Y, Kitazono T.

Hematol Oncol. 2020年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Clinical Risk Factors of Thromboembolic and Major Bleeding Events for Patients with Atrial Fibrillation Treated with Rivaroxaban in Japan. 査読国際誌

Miyamoto S, Ikeda T, Ogawa S, Kitazono T, Nakagawara J, Minematsu K, Murakawa Y, Iwashiro S, Takeichi M, Kidani Y, Okayama Y, Sunaya T, Sato S, Yamanaka S.

J Stroke Cerebrovasc Dis. 2020年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Safety and Efficacy of Prasugrel in Elderly/Low Body Weight Japanese Patients with Ischemic Stroke: Randomized PRASTRO-II. 査読国際誌

Kitagawa K, Toyoda K, Kitazono T, Nishikawa M, Nanto S, Ikeda Y, Abe K, Ogawa A.

Cerebrovasc Dis. 2020年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Ratios of serum eicosapentaenoic acid to arachidonic acid and docosahexaenoic acid to arachidonic acid were inversely associated with serum resistin levels: The Hisayama Study. 査読国際誌

Higashioka M, Hirakawa Y, Kawamura R, Honda T, Hata J, Yoshida D, Takata Y, Kitazono T, Osawa H, Ninomiya T.

J Diabetes Investig. 2020年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Real-world outcomes of rivaroxaban treatment in elderly Japanese patients with nonvalvular atrial fibrillation. 査読国際誌

Kitazono T, Ikeda T, Ogawa S, Nakagawara J, Minematsu K, Miyamoto S, Murakawa Y, Cavaliere M, Hayashi Y, Kidani Y, Okayama Y, Sunaya T, Sato S, Yamanaka S.

Heart Vessels. 2020年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Short-term and long-term outcomes of indigo naturalis treatment for inflammatory bowel disease. 査読国際誌

Matsuno Y, Hirano A, Torisu T, Okamoto Y, Fuyuno Y, Fujioka S, Umeno J, Moriyama T, Nagai S, Hori Y, Fujiwara M, Kitazono T, Esaki M.

J Gastroenterol Hepatol. 2020年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Smoking Status and Functional Outcomes After Acute Ischemic Stroke. 査読国際誌

Matsuo R, Ago T, Kiyuna F, Sato N, Nakamura K, Kuroda J, Wakisaka Y, Kitazono T; Fukuoka Stroke Registry Investigators.

Stroke. 2020年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Pericyte-Mediated Tissue Repair through PDGFRβ Promotes Peri-Infarct Astrogliosis, Oligodendrogenesis, and Functional Recovery after Acute Ischemic Stroke. 査読国際誌

2020年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Early Initiation of Direct Oral Anticoagulants After Onset of Stroke and Short- and Long-Term Outcomes of Patients With Nonvalvular Atrial Fibrillation. 査読国際誌

Mizoguchi T, Tanaka K, Toyoda K, Yoshimura S, Itabashi R, Takagi M, Todo K, Shiozawa M, Yagita Y, Yoshimoto T, Terasaki T, Yamagami H, Takizawa S, Inoue M, Kamiyama K, Ihara M, Okada Y, Kitazono T, Koga M; SAMURAI Study Investigators.

Stroke. 2020年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Colorectal diffuse large B-cell lymphoma: molecular subclassification and prognostic significance of immunoglobulin gene translocation. 査読国際誌

Hori Y, Yamamoto H, Nozaki Y, Torisu T, Fujiwara M, Taguchi K, Nishiyama K, Nakamura S, Kitazono T, Oda Y.

Hum Pathol. 2020年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Lower Serum Albumin Level Is Associated With an Increased Risk for Loss of Residual Kidney Function in Patients Receiving Peritoneal Dialysis. 査読国際誌

Yamada S, Kawai Y, Tsuneyoshi S, Tsujikawa H, Arase H, Yoshida H, Tsuruya K, Nakano T, Kitazono T.

Ther Apher Dial. 2020年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Lidocaine-Propitocain Cream, a Eutectic Mixture of Local Anesthetics, Effectively Relieves Pain Associated With Vascular Access Intervention Therapy in Patients Undergoing Hemodialysis: A Placebo-Controlled, Double-Blind, Crossover Study. 査読国際誌

Aihara S, Yamada S, Shichijo S, Fukumitsu K, Kondo M, Hirashima Y, Oka H, Kamimura T, Harada A, Nakano T, Tsuruya K, Kitazono T.

Ther Apher Dial. 2020年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Predictive Factors for Rebleeding after Negative Capsule Endoscopy among Patients with Overt Obscure Gastrointestinal Bleeding. 査読国際誌

Harada A, Torisu T, Okamoto Y, Hirano A, Umeno J, Moriyama T, Washio E, Fuyuno Y, Fujioka S, Kitazono T, Esaki M.

Digestion. 2020年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Impact of hip fracture on all-cause mortality in Japanese patients with type 2 diabetes mellitus: The Fukuoka Diabetes Registry. 査読国際誌

Komorita Y, Iwase M, Idewaki Y, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Yoshinari M, Murao-Kimura A, Oku Y, Nakamura U, Kitazono T.

J Diabetes Investig. 2020年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Modified creatinine index and risk for long-term infection-related mortality in hemodialysis patients: ten-year outcomes of the Q-Cohort Study. 査読国際誌

Arase H, Yamada S, Hiyamuta H, Taniguchi M, Tokumoto M, Tsuruya K, Nakano T, Kitazono T.

Sci Rep. 2020年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Advanced glycation end products are associated with immature angiogenesis and peritoneal dysfunction in patients on peritoneal dialysis. 査読国際誌

Nakano T, Mizumasa T, Kuroki Y, Eriguchi M, Yoshida H, Taniguchi M, Masutani K, Tsuruya K, Kitazono T.

Perit Dial Int. 2020年1月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Real-world Outcomes of Rivaroxaban Treatment in Patients With Nonvalvular Atrial Fibrillation and Worsening Renal Function 査読国際誌

Nakagawara J, Ikeda T, Ogawa S, Kitazono T, Minematsu K, Miyamoto S, Murakawa Y, Takeichi M, Kidani Y, Okayama Y, Sunaya T, Sato S, Yamanaka S.

J Cardiol. 2019年12月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Prasugrel for Japanese Patients With Ischemic Heart Disease in Long-Term Clinical Practice (PRASFIT-Practice II) - 1-Year Follow-up Results of a Postmarketing Observational Study 査読国際誌

Nakamura M, Kitazono T, Kozuma K, Sekine T, Nakamura S, Shiosakai K, Iizuka T.

Circ J. 2019年12月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Serum Elaidic Acid Concentration and Risk of Dementia: The Hisayama Study 査読国際誌

Honda T, Ohara T, Shinohara M, Hata J, Toh R, Yoshida D, Shibata M, Ishida T, Hirakawa Y, Irino Y, Sakata S, Uchida K, Kitazono T, Kanba S, Hirata KI, Ninomiya T.

Neurology. 2019年11月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Serum Lipopolysaccharide-Binding Protein Levels and the Incidence of Cardiovascular Disease in a General Japanese Population: The Hisayama Study 査読国際誌

Asada M, Oishi E, Sakata S, Hata J, Yoshida D, Honda T, Furuta Y, Shibata M, Suzuki K, Watanabe H, Murayama N, Kitazono T, Yamaura K, Ninomiya T.

J Am Heart Assoc. 2019年11月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Development and Validation of a New Prediction Model for Graft Function Using Preoperative Marginal Factors in Living-Donor Kidney Transplantation 査読国際誌

Matsukuma Y, Masutani K, Tanaka S, Tsuchimoto A, Nakano T, Okabe Y, Kakuta Y, Okumi M, Tsuruya K, Nakamura M, Kitazono T, Tanabe K; Japan Academic Consortium of Kidney Transplantation (JACK) Investigators.

Clin Exp Nephrol. 2019年11月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Higher Cholesterol Level Predicts Cardiovascular Event and Inversely Associates With Mortality in Hemodialysis Patients: 10-Year Outcomes of the Q-Cohort Study 査読国際誌

Nakano T, Hiyamuta H, Yotsueda R, Tanaka S, Taniguchi M, Tsuruya K, Kitazono T.

Ther Apher Dial. 2019年11月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Global Outcome Assessment Life-long After Stroke in Young Adults Initiative-The GOAL Initiative: Study Protocol and Rationale of a Multicentre Retrospective Individual Patient Data Meta-Analysis 査読国際誌

BMJ Open. 2019年11月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Clinical Risk Factors of Stroke and Major Bleeding in Patients With Non-Valvular Atrial Fibrillation Under Rivaroxaban: The EXPAND Study Sub-Analysis 査読国際誌

Sakuma I, Uchiyama S, Atarashi H, Inoue H, Kitazono T, Yamashita T, Shimizu W, Ikeda T, Kamouchi M, Kaikita K, Fukuda K, Origasa H, Shimokawa H.

Heart Vessels. 2019年11月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Small Dense Low-Density Lipoprotein Cholesterol and the Risk of Coronary Heart Disease in a Japanese Community 査読国際誌

Higashioka M, Sakata S, Honda T, Hata J, Yoshida D, Hirakawa Y, Shibata M, Goto K, Kitazono T, Osawa H, Ninomiya T.

J Atheroscler Thromb. 2019年11月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Outcomes Associated With Under-Dosing of Rivaroxaban for Management of Non-Valvular Atrial Fibrillation in Real-World Japanese Clinical Settings 査読国際誌

Ikeda T, Ogawa S, Kitazono T, Nakagawara J, Minematsu K, Miyamoto S, Murakawa Y, Iwashiro S, Kidani Y, Okayama Y, Sunaya T, Sato S, Yamanaka S.

J Thromb Thrombolysis. 2019年11月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
High neutrophil/lymphocyte Ratio Is Associated With Poor Renal Outcomes in Japanese Patients With Chronic Kidney Disease 査読国際誌

Yoshitomi R, Nakayama M, Sakoh T, Fukui A, Katafuchi E, Seki M, Tsuda S, Nakano T, Tsuruya K, Kitazono T.

Ren Fail. 2019年11月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Development of Quality Indicators of Stroke Centers and Feasibility of Their Measurement Using a Nationwide Insurance Claims Database in Japan ― J-ASPECT Study ― 査読国際誌

2019年10月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Hemodialysis Treatment Time Versus Erythropoietin Dose Requirement: Reduction in 2,000 Units Per Week by Extension of Hemodialysis for 1 Hour 査読国際誌

Maeda A, Tsuruya K, Maeda M, Yamasaki M, Nakashima A, Nakashima Y, Date S, Maeda T, Kamijyou M, Kubara T, Hayashi W, Kitazono T.

Clin Nephrol. 2019年10月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Upregulation of Annexin A1 in Reactive Astrocytes and Its Subtle Induction in Microglia at the Boundaries of Human Brain Infarcts 査読国際誌

Shijo M, Hamasaki H, Honda H, Suzuki SO, Tachibana M, Ago T, Kitazono T, Iihara K, Iwaki T.

J Neuropathol Exp Neurol. 2019年10月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Factors Associated With Postprocedural Diffusion-Weighted Imaging-Positive Lesions in Endovascular Treatment for Unruptured Cerebral Aneurysms 査読国際誌

Tokunaga K, Hatano T, Nakahara I, Ishii A, Higashi E, Kamata T, Funakoshi Y, Hashikawa T, Takita W, Chihara H, Ando M, Sadamasa N, Kitazono T, Nagata I.

World Neurosurg. 2019年10月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Real-World Outcomes of Rivaroxaban Treatment in Patients With Both Nonvalvular Atrial Fibrillation and a History of Ischemic Stroke/Transient Ischemic Attack 査読国際誌

Minematsu K, Ikeda T, Ogawa S, Kitazono T, Nakagawara J, Miyamoto S, Murakawa Y, Takeichi M, Kidani Y, Okayama Y, Sunaya T, Sato S, Yamanaka S.

Cerebrovasc Dis. 2019年10月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
National Trends in Outcomes of Ischemic Stroke and Prognostic Influence of Stroke Center Capability in Japan, 2010-2016 査読国際誌

Kada A, Ogasawara K, Kitazono T, Nishimura K, Sakai N, Onozuka D, Shiokawa Y, Miyachi S, Nagata I, Toyoda K, Hashimoto Y, Hasegawa Y, Hoshino H, Yoshimura S, Suzuki M, Tsujino A, Matsuda S, Kurogi R, Kurogi A, Ren N, Nishimura A, Arimura K, Hagihara A, Tominaga T, Kayama T, Arai H, Suzuki N, Miyamoto S, Ogawa A, Iihara K; J-ASPECT Study Collaborators.

Int J Stroke. 2019年10月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Risk Factors for Reflux Esophagitis After Eradication of Helicobacter pylori 査読国際誌

Harada A, Kurahara K, Moriyama T, Tanaka T, Nagata Y, Kawasaki K, Yaita H, Maehata Y, Umeno J, Oshiro Y, Fuchigami T, Kitazono T, Esaki M, Matsumoto T.

Scand J Gastroenterol. 2019年10月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
NT-proBNP and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study 査読国際誌

Nagata T, Ohara T, Hata J, Sakata S, Furuta Y, Yoshida D, Honda T, Hirakawa Y, Ide T, Kanba S, Kitazono T, Tsutsui H, Ninomiya T.

J Am Heart Assoc. 2019年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Usefulness of Transesophageal Echocardiography for Predicting Covert Paroxysmal Atrial Fibrillation in Patients With Embolic Stroke of Undetermined Source 査読国際誌

Ohya Y, Osaki M, Fujimoto S, Jinnouchi J, Matsuki T, Mezuki S, Kumamoto M, Kanazawa M, Tagawa N, Ago T, Kitazono T, Arakawa S.

Cerebrovasc Dis Extra. 2019年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Early Initiation of a Factor Xa Inhibitor Can Attenuate Tissue Repair and Neurorestoration After Middle Cerebral Artery Occlusion 査読国際誌

Komori M, Ago T, Wakisaka Y, Nakamura K, Tachibana M, Yoshikawa Y, Shibahara T, Yamanaka K, Kuroda J, Kitazono T.

Brain Res. 2019年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Reduced Estimated GFR and Cardiac Remodeling: A Population-Based Autopsy Study 査読国際誌

Izumaru K, Hata J, Nakano T, Nakashima Y, Nagata M, Fukuhara M, Oda Y, Kitazono T, Ninomiya T.

Am J Kidney Dis. 2019年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association Between Serum β-Alanine and Risk of Dementia 査読国際誌

2019年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Relative Hypophosphatemia Early After Transplantation Is a Predictor of Good Kidney Graft Function 招待査読国際誌

Nakai K, Mitsuiki K, Kuroki Y, Nishiki T, Motoyama K, Nakano T, Kitazono T.

Clin Exp Nephrol. 2019年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Real-world Outcomes of the Xarelto Post-Authorization Safety & Effectiveness Study in Japanese Patients With Atrial Fibrillation (XAPASS) 査読国際誌

Ikeda T, Ogawa S, Kitazono T, Nakagawara J, Minematsu K, Miyamoto S, Murakawa Y, Takeichi M, Ohashi Y, Okayama Y, Sunaya T, Yamanaka S.

J Cardiol. 2019年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Risk of Surgery in Patients With Stricturing Type of Crohn's Disease at the Initial Diagnosis: A Single Center Experience 査読国際誌

Maehata Y, Nagata Y, Moriyama T, Matsuno Y, Hirano A, Umeno J, Torisu T, Manabe T, Kitazono T, Esaki M.

Intest Res. 2019年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Endoscopic Features of Gastrointestinal Stromal Tumor in the Small Intestine 査読国際誌

Ihara Y, Torisu T, Moriyama T, Umeno J, Hirano A, Okamoto Y, Hori Y, Yamamoto H, Kitazono T, Esaki M.

Intest Res. 2019年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
The Long-Term Follow-Up of Patients With Thionamide-Treated Graves' Hyperthyroidism 招待査読国際誌

Bandai S, Okamura K, Fujikawa M, Sato K, Ikenoue H, Kitazono T.

Endocr J. 2019年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Predictive Value of the Combination of Peripheral Blood Lymphocyte Count and Urinary Cytology in BK Polyomavirus-associated Nephropathy 査読国際誌

Masutani K, Tsuchimoto A, Matsukuma Y, Tanaka S, Kaku K, Noguchi H, Kurihara K, Okabe Y, Nakano T, Tsuruya K, Nakashima H, Nakamura M, Kitazono T.

Transplant Proc. 2019年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Arterial Spin Labeling Magnetic Resonance Imaging for Differentiating Acute Ischemic Stroke From Epileptic Disorders 査読国際誌

Kanazawa Y, Arakawa S, Shimogawa T, Hagiwara N, Haga S, Morioka T, Ooboshi H, Ago T, Kitazono T.

J Stroke Cerebrovasc Dis. 2019年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Dairy Consumption and Risk of Functional Disability in an Elderly Japanese Population: The Hisayama Study 査読国際誌

Yoshida D, Ohara T, Hata J, Shibata M, Hirakawa Y, Honda T, Uchida K, Takasugi S, Kitazono T, Kiyohara Y, Ninomiya T.

Am J Clin Nutr. 2019年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Angiotensin-converting Enzyme Inhibitors Versus Angiotensin Receptor Blockers in Hypertensive Patients With Myocardial Infarction or Heart Failure: A Systematic Review and Meta-Analysis 査読国際誌

Ohtsubo T, Shibata R, Kai H, Okamoto R, Kumagai E, Kawano H, Fujiwara A, Kitazono T, Murohara T, Arima H.

Hypertens Res. 2019年5月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Poor Glycemic Control and Posterior Circulation Ischemic Stroke 査読国際誌

Kuroda J, Matsuo R, Yamaguchi Y, Sato N, Kamouchi M, Hata J, Wakisaka Y, Ago T, Kitazono T; Fukuoka Stroke Registry Investigators.

Neurol Clin Pract. 2019年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Blood Urea Nitrogen Is Independently Associated With Renal Outcomes in Japanese Patients With Stage 3-5 Chronic Kidney Disease: A Prospective Observational Study 査読国際誌

Seki M, Nakayama M, Sakoh T, Yoshitomi R, Fukui A, Katafuchi E, Tsuda S, Nakano T, Tsuruya K, Kitazono T.

BMC Nephrol. 2019年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Anti-tumor Necrosis Factor Therapy Decreases the Risk of Initial Intestinal Surgery After Diagnosis of Crohn's Disease of Inflammatory Type 査読国際誌

Nagata Y, Esaki M, Moriyama T, Hirano A, Umeno J, Maehata Y, Torisu T, Matsumoto T, Kitazono T.

J Gastroenterol. 2019年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Better Oral Hygiene Habits Are Associated With a Lower Incidence of Peritoneal Dialysis-Related Peritonitis 査読国際誌

Oka H, Yamada S, Kamimura T, Aihara S, Hyodo M, Terakado N, Harada A, Nakano T, Tsuruya K, Kitazono T.

Ther Apher Dial. 2019年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Kidney Transplantation for Treatment of End-Stage Kidney Disease After Haematopoietic Stem Cell Transplantation: Case Series and Literature Review 査読国際誌

Tsuchimoto A, Masutani K, Omoto K, Okumi M, Okabe Y, Nishiki T, Ota M, Nakano T, Tsuruya K, Kitazono T, Nakamura M, Ishida H, Tanabe K; Japan Academic Consortium of Kidney Transplantation (JACK) Investigators.

Clin Exp Nephrol. 2019年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Measurement of Prostaglandin Metabolites Is Useful in Diagnosis of Small Bowel Ulcerations 査読国際誌

Matsuno Y, Umeno J, Esaki M, Hirakawa Y, Fuyuno Y, Okamoto Y, Hirano A, Yasukawa S, Hirai F, Matsui T, Hosomi S, Watanabe K, Hosoe N, Ogata H, Hisamatsu T, Yanai S, Kochi S, Kurahara K, Yao T, Torisu T, Kitazono T, Matsumoto T.

World J Gastroenterol. 2019年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
C-reactive Protein and Incident Hypertension in a Worksite Population of Japanese Men 査読国際誌

Kansui Y, Matsumura K, Morinaga Y, Inoue M, Kiyohara K, Ohta Y, Goto K, Ohtsubo T, Ooboshi H, Kitazono T.

J Clin Hypertens (Greenwich). 2019年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Rapidly Progressive Glomerulonephritis With Delayed Appearance of Anti-Glomerular Basement Membrane Antibody Successfully Treated With Multiple Courses of Steroid Pulse Therapy 査読国際誌

Toyota S, Eriguchi M, Hasegawa S, Ueki K, Matsukuma Y, Tsuchimoto A, Fujisaki K, Torisu K, Tsuruya K, Nakano T, Kitazono T.

Case Rep Nephrol Dial. 2019年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Achieving LDL Cholesterol Target Levels <1.81 mmol/L May Provide Extra Cardiovascular Protection in Patients at High Risk: Exploratory Analysis of the Standard Versus Intensive Statin Therapy for Patients With Hypercholesterolaemia and Diabetic Retinopathy Study 査読国際誌

Itoh H, Komuro I, Takeuchi M, Akasaka T, Daida H, Egashira Y, Fujita H, Higaki J, Hirata KI, Ishibashi S, Isshiki T, Ito S, Kashiwagi A, Kato S, Kitagawa K, Kitakaze M, Kitazono T, Kurabayashi M, Miyauchi K, Murakami T, Murohara T, Node K, Ogawa S, Saito Y, Seino Y, Shigeeda T, Shindo S, Sugawara M, Sugiyama S, Terauchi Y, Tsutsui H, Ueshima K, Utsunomiya K, Yamagishi M, Yamazaki T, Yo S, Yokote K, Yoshida K, Yoshimura M, Yoshimura N, Nakao K, Nagai R; EMPATHY Investigators.

Diabetes Obes Metab. 2019年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Trends in the Prevalence of Airflow Limitation in a General Japanese Population: Two Serial Cross-Sectional Surveys From the Hisayama Study 査読国際誌

Ogata H, Hirakawa Y, Matsumoto K, Hata J, Yoshida D, Fukuyama S, Inoue H, Kitazono T, Ninomiya T, Nakanishi Y.

BMJ Open. 2019年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Early Postoperative Change in Serum Creatinine Predicts Acute Kidney Injury After Cardiothoracic Surgery: A Retrospective Cohort Study 査読国際誌

Oka H, Yamada S, Kamimura T, Harada A, Tsuruya K, Nakano T, Kitazono T.

Clin Exp Nephrol. 2019年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of B-Type Natriuretic Peptide Level With Residual Kidney Function in Incident Peritoneal Dialysis Patients 査読国際誌

Kawai Y, Tanaka S, Yoshida H, Hara M, Tsujikawa H, Tsuruya K, Kitazono T.

Perit Dial Int. 2019年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Development of a Risk Prediction Model for Infection-Related Mortality in Patients Undergoing Peritoneal Dialysis 査読国際誌

Tsujikawa H, Tanaka S, Matsukuma Y, Kanai H, Torisu K, Nakano T, Tsuruya K, Kitazono T.

PLoS One. 2019年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Capsule Endoscopy Findings for the Diagnosis of Crohn's Disease: A Nationwide Case-Control Study 査読国際誌

Esaki M, Matsumoto T, Ohmiya N, Washio E, Morishita T, Sakamoto K, Abe H, Yamamoto S, Kinjo T, Togashi K, Watanabe K, Hirai F, Nakamura M, Nouda S, Ashizuka S, Omori T, Kochi S, Yanai S, Fuyuno Y, Hirano A, Umeno J, Kitazono T, Kinjo F, Watanabe M, Matsui T, Suzuki Y.

J Gastroenterol. 2019年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Serum Magnesium and Calcium Levels in Relation to Ischemic Stroke: Mendelian Randomization Study 査読国際誌

Neurology. 2019年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Prasugrel for Japanese Patients With Ischemic Heart Disease in Long-Term Clinical Practice (PRASFIT-Practice II) - A 3-Month Interim Analysis of a Postmarketing Observational Study 査読国際誌

Nakamura M, Kozuma K, Kitazono T, Iizuka T, Sekine T, Shiosakai K, Usui I, Kogure S.

Circ J. 2019年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of Geriatric Nutritional Risk Index With Infection-Related Mortality in Patients Undergoing Hemodialysis: The Q-Cohort Study 査読国際誌

Matsukuma Y, Tanaka S, Taniguchi M, Nakano T, Masutani K, Hirakata H, Kitazono T, Tsuruya K.

Clin Nutr. 2019年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Colorectal Endoscopic Submucosal Dissection Using Novel Articulating Devices: A Comparative Study in a Live Porcine Model 査読国際誌

Okamoto Y, Nakadate R, Nakamura S, Arata J, Oguri S, Moriyama T, Esaki M, Iwasa T, Ohuchida K, Akahoshi T, Ikeda T, Kitazono T, Hashizume M.

Surg Endosc. 2019年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Prospective Study of Cancer in Japanese Patients With Type 2 Diabetes: The Fukuoka Diabetes Registry 査読国際誌

Iwase M, Fujii H, Idewaki Y, Nakamura U, Ohkuma T, Ide H, Komorita Y, Jodai-Kitamura T, Yoshinari M, Kitazono T.

Diabetol Int. 2019年2月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Primary and Secondary Prevention of Stroke and Systemic Embolism With Rivaroxaban in Patients With Non-Valvular Atrial Fibrillation : Sub-analysis of the EXPAND Study 査読国際誌

Uchiyama S, Atarashi H, Inoue H, Kitazono T, Yamashita T, Shimizu W, Ikeda T, Kamouchi M, Kaikita K, Fukuda K, Origasa H, Shimokawa H.

Heart Vessels. 2019年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Primary and Secondary Prevention of Stroke and Systemic Embolism With Rivaroxaban in Patients With Non-Valvular Atrial Fibrillation : Sub-analysis of the EXPAND Study 査読国際誌

Uchiyama S, Atarashi H, Inoue H, Kitazono T, Yamashita T, Shimizu W, Ikeda T, Kamouchi M, Kaikita K, Fukuda K, Origasa H, Shimokawa H.

Heart Vessels. 2019年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Apparent Treatment-Resistant Hypertension and Cardiovascular Risk in Hemodialysis Patients: Ten-Year Outcomes of the Q-Cohort Study 査読国際誌

Tanaka S, Ninomiya T, Hiyamuta H, Taniguchi M, Tokumoto M, Masutani K, Ooboshi H, Nakano T, Tsuruya K, Kitazono T.

Sci Rep. 2019年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Serum Soluble Triggering Receptor Expressed on Myeloid Cells 2 as a Biomarker for Incident Dementia: The Hisayama Study 査読国際誌

Ohara T, Hata J, Tanaka M, Honda T, Yamakage H, Yoshida D, Inoue T, Hirakawa Y, Kusakabe T, Shibata M, Teraoka T, Kitazono T, Kanba S, Satoh-Asahara N, Ninomiya T.

Ann Neurol. 2019年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Utility of Columbia Classification in Focal Segmental Glomerulosclerosis: Renal Prognosis and Treatment Response Among the Pathological Variants 査読国際誌

Tsuchimoto A, Matsukuma Y, Ueki K, Tanaka S, Masutani K, Nakagawa K, Mitsuiki K, Uesugi N, Katafuchi R, Tsuruya K, Nakano T, Kitazono T.

Nephrol Dial Transplant. 2019年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Prevalence of Adult Epilepsy in a General Japanese Population: The Hisayama Study 査読国際誌

Tanaka A, Hata J, Akamatsu N, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Ohara T, Mizuno T, Tsuji S, Kitazono T, Ninomiya T.

Epilepsia Open. 2019年1月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Prognostic value of pre-dialysis blood pressure and risk threshold on clinical outcomes in hemodialysis patients: The Q-Cohort Study. 査読国際誌

Hara M, Tanaka S, Taniguchi M, Fujisaki K, Torisu K, Masutani K, Hirakata H, Nakano T, Tsuruya K, Kitazono T.

Medicine (Baltimore). 2018年12月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
The serum creatinine to cystatin C ratio predicts bone fracture in patients with type 2 diabetes: The Fukuoka Diabetes Registry. 査読国際誌

Komorita Y, Iwase M, Fujii H, Ide H, Ohkuma T, Jodai-Kitamura T, Sumi A, Yoshinari M, Nakamura U, Kitazono T.

Diabetes Res Clin Pract. 2018年12月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Development and validation of modified risk prediction models for cardiovascular disease and its subtypes: The Hisayama Study. 査読国際誌

Honda T, Yoshida D, Hata J, Hirakawa Y, Ishida Y, Shibata M, Sakata S, Kitazono T, Ninomiya T.

Atherosclerosis. 2018年12月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Impact of obstructive sleep apnea on long-term blood pressure variability in Japanese men: a cross-sectional study of a work-site population. 査読国際誌

Kansui Y, Matsumura K, Morinaga Y, Inoue M, Sakata S, Oishi E, Goto K, Ohtsubo T, Ooboshi H, Kitazono T.

Hypertens Res. 2018年11月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
A case of congenital left ventricular diverticulum in a patient with autosomal dominant polycystic kidney disease: possible mechanistic link between polycystin and ventricular diverticulum. 査読国際誌

Aihara S, Yamada S, Matsusaka H, Tashiro R, Oka H, Kamimura T, Harada A, Nakano T, Kitazono T, Tsuruya K.

CEN Case Rep. 2018年11月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Subacute Methotrexate Encephalopathy Mimicking Ischemic Stroke With Dynamic Changes on Magnetic Resonance Imaging. 査読国際誌

Yamanaka K, Okata T, Sambongi Y, Yamanaka I, Tanimoto K, Ago T, Kitazono T, Kitayama J.

J Stroke Cerebrovasc Dis. 2018年11月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Influence of cytochrome P450 polymorphisms on the antiplatelet effects of prasugrel in patients with non-cardioembolic stroke previously treated with clopidogrel. 査読国際誌

Kitazono T, Ikeda Y, Nishikawa M, Yoshiba S, Abe K, Ogawa A.

J Thromb Thrombolysis. 2018年11月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Safety of antithrombotic therapy for patients with acute ischemic stroke harboring unruptured intracranial aneurysm. 査読国際誌

Shono Y, Sugimori H, Matsuo R, Fukushima Y, Wakisaka Y, Kuroda J, Ago T, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators

Int J Stroke 2018年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Association Between Daily Sleep Duration and Risk of Dementia and Mortality in a Japanese Community. 査読国際誌

Ohara T, Honda T, Hata J, Yoshida D, Mukai N, Hirakawa Y, Shibata M, Kishimoto H, Kitazono T, Kanba S, Ninomiya T.

J Am Geriatr Soc. 2018年10月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Anti-Xa Activity and Event Risk in Patients With Direct Factor Xa Inhibitors Initiated Early After Stroke. 査読国際誌

Wada S, Toyoda K, Sato S, Matsuki T, Okata T, Kumamoto M, Tagawa N, Inoue M, Okamoto A, Ihara M, Kitazono T, Miyata T, Koga M.

Circ J. 2018年10月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Immobilization-induced severe hypercalcaemia successfully treated with reduced dose of zoledronate in a maintenance haemodialysis patient. 査読国際誌

Yamada S, Arase H, Tachibana S, Tomita K, Eriguchi M, Fujisaki K, Okabe Y, Nakamura M, Nakano T, Tsuruya K, Kitazono T.

Nephrology (Carlton). 2018年10月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Association of Embolic Sources With Cause-Specific Functional Outcomes Among Adults With Cryptogenic Stroke. 査読国際誌

Kiyuna F, Sato N, Matsuo R, Kamouchi M, Hata J, Wakisaka Y, Kuroda J, Ago T, Kitazono T; Fukuoka Stroke Registry Investigators.

JAMA Netw Open. 2018年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Impact of age at menarche on obesity and glycemic control in Japanese patients with type 2 diabetes: Fukuoka Diabetes Registry. 査読国際誌

Sumi A, Iwase M, Nakamura U, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Komorita Y, Yoshinari M, Kitazono T.

J Diabetes Investig. 2018年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association between the ratio of serum arachidonic acid to eicosapentaenoic acid and the presence of depressive symptoms in a general Japanese population: the Hisayama Study. 査読国際誌

Shibata M, Ohara T, Yoshida D, Hata J, Mukai N, Kawano H, Kanba S, Kitazono T, Ninomiya T.

J Affect Disord. 2018年9月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Association between stroke-like episodes and neuronal hyperexcitability in MELAS with m.3243A>G: A case report. 査読国際誌

Sakai S, Osaki M, Hidaka M, Kimura S, Ohya Y, Ago T, Kitazono T, Arakawa S.

eNeurologicalSci. 2018年8月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Clinical features of chronic enteropathy associated with SLCO2A1 gene: a new entity clinically distinct from Crohn's disease. 査読国際誌

Umeno J, Esaki M, Hirano A, Fuyuno Y, Ohmiya N, Yasukawa S, Hirai F, Kochi S, Kurahara K, Yanai S, Uchida K, Hosomi S, Watanabe K, Hosoe N, Ogata H, Hisamatsu T, Nagayama M, Yamamoto H, Abukawa D, Kakuta F, Onodera K, Matsui T, Hibi T, Yao T, Kitazono T, Matsumoto T; CEAS study group.

J Gastroenterol. 2018年8月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Modified creatinine index and risk for cardiovascular events and all-cause mortality in patients undergoing hemodialysis: The Q-Cohort study. 査読国際誌

Arase H, Yamada S, Yotsueda R, Taniguchi M, Yoshida H, Tokumoto M, Nakano T, Tsuruya K, Kitazono T.

Atherosclerosis. 2018年8月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Overexpression of MTH1 and OGG1 proteins in ulcerative colitis-associated carcinogenesis. 査読国際誌

Kumagae Y, Hirahashi M, Takizawa K, Yamamoto H, Gushima M, Esaki M, Matsumoto T, Nakamura M, Kitazono T, Oda Y.

Oncol Lett. 2018年8月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Use of phosphate-binders and risk of infection-related and all-cause mortality in patients undergoing hemodialysis: The Q-Cohort Study. 査読国際誌

Yamada S, Tokumoto M, Taniguchi M, Yoshida H, Arase H, Tatsumoto N, Hirakata H, Kitazono T, Tsuruya K.

Sci Rep. 2018年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Thrombolytic Therapy in Severe Cardioembolic Stroke After Reversal of Dabigatran with Idarucizumab: Case Report and Literature Review. 査読国際誌

Ohya Y, Makihara N, Wakisaka K, Morita T, Ago T, Kitazono T, Takaba H.

J Stroke Cerebrovasc Dis. 2018年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Paradoxical Brain Embolism in Elderly Subjects with Small Atrial Septal Defects. 査読国際誌

Kitamura T, Arakawa S, Murao K, Kitazono T, Ago T.

J Stroke Cerebrovasc Dis. 2018年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Impact of serum uric acid on incident hypertension in a worksite population of Japanese men. 査読国際誌

Kansui Y, Matsumura K, Morinaga Y, Inoue M, Kiyohara K, Ohta Y, Goto K, Ohtsubo T, Ooboshi H, Kitazono T.

J Hypertens. 2018年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Metyrapone-responsive ectopic ACTH-secreting pheochromocytoma with a vicious cycle via a glucocorticoid-driven positive-feedback mechanism. 査読国際誌

Inoue M, Okamura K, Kitaoka C, Kinoshita F, Namitome R, Nakamura U, Shiota M, Goto K, Ohtsubo T, Matsumura K, Oda Y, Eto M, Kitazono T.

Endocr J. 2018年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Effect of steroid pulse therapy on post-transplant immunoglobulin A nephropathy. 査読国際誌

Matsukuma Y, Masutani K, Tsuchimoto A, Okabe Y, Nakamura M, Kitazono T, Tsuruya K.

Nephrology (Carlton). 2018年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Serum 1,25-Dihydroxyvitamin D Level Is Inappropriate for Use in Prospective Studies of Cancer Incidence　- Reply. 査読国際誌

2018年7月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Prevalence of and risk factors for cerebral microbleeds in a general Japanese elderly community. 査読国際誌

Yubi T, Hata J, Ohara T, Mukai N, Hirakawa Y, Yoshida D, Gotoh S, Hirabayashi N, Furuta Y, Ago T, Kitazono T, Kiyohara Y, Ninomiya T.

Neurol Clin Pract. 2018年6月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Secular trends in the incidence of end-stage renal disease and its risk factors in Japanese patients with immunoglobulin A nephropathy. 査読国際誌

Tanaka S, Ninomiya T, Katafuchi R, Masutani K, Tsuchimoto A, Tokumoto M, Hirakata H, Ooboshi H, Kitazono T, Tsuruya K.

Nephrol Dial Transplant. 2018年6月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Intensive Treat-to-Target Statin Therapy in High-Risk Japanese Patients With Hypercholesterolemia and Diabetic Retinopathy: Report of a Randomized Study. 査読国際誌

Itoh H, Komuro I, Takeuchi M, Akasaka T, Daida H, Egashira Y, Fujita H, Higaki J, Hirata KI, Ishibashi S, Isshiki T, Ito S, Kashiwagi A, Kato S, Kitagawa K, Kitakaze M, Kitazono T, Kurabayashi M, Miyauchi K, Murakami T, Murohara T, Node K, Ogawa S, Saito Y, Seino Y, Shigeeda T, Shindo S, Sugawara M, Sugiyama S, Terauchi Y, Tsutsui H, Ueshima K, Utsunomiya K, Yamagishi M, Yamazaki T, Yo S, Yokote K, Yoshida K, Yoshimura M, Yoshimura N, Nakao K, Nagai R; EMPATHY Investigators.

Diabetes Care. 2018年6月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Secular trends in the incidence, risk factors, and prognosis of transient ischemic attack in Japan: The Hisayama Study. 査読国際誌

Furuta Y, Hata J, Mukai N, Hirakawa Y, Ago T, Kitazono T, Kiyohara Y, Ninomiya T.

Atherosclerosis. 2018年6月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Association between serum albumin level and incidence of end-stage renal disease in patients with Immunoglobulin A nephropathy: A possible role of albumin as an antioxidant agent. 査読国際誌

Kawai Y, Masutani K, Torisu K, Katafuchi R, Tanaka S, Tsuchimoto A, Mitsuiki K, Tsuruya K, Kitazono T.

PLoS One. 2018年5月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
The EXPAND study: Efficacy and safety of rivaroxaban in Japanese patients with non-valvular atrial fibrillation. 査読国際誌

Shimokawa H, Yamashita T, Uchiyama S, Kitazono T, Shimizu W, Ikeda T, Kamouchi M, Kaikita K, Fukuda K, Origasa H, Sakuma I, Saku K, Okumura Y, Nakamura Y, Morimoto H, Matsumoto N, Tsuchida A, Ako J, Sugishita N, Shimizu S, Atarashi H, Inoue H.

Int J Cardiol. 2018年5月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Development and validation of a risk assessment tool for gastric cancer in a general Japanese population. 査読国際誌

Iida M, Ikeda F, Hata J, Hirakawa Y, Ohara T, Mukai N, Yoshida D, Yonemoto K, Esaki M, Kitazono T, Kiyohara Y, Ninomiya T.

Gastric Cancer. 2018年5月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Hemoglobin concentration and the risk of hemorrhagic and ischemic stroke in patients undergoing hemodialysis: the Q-cohort study. 査読国際誌

Yotsueda R, Tanaka S, Taniguchi M, Fujisaki K, Torisu K, Masutani K, Hirakata H, Kitazono T, Tsuruya K.

Nephrol Dial Transplant. 2018年5月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
A case of hyperparathyroidism-associated parkinsonism successfully treated with cinacalcet hydrochloride, a calcimimetic. 査読国際誌

Ohya Y, Osaki M, Sakai S, Kimura S, Yasuda C, Ago T, Kitazono T, Arakawa S.

BMC Neurol. 2018年5月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. 査読国際誌

Nat Genet. 2018年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
A noninferiority confirmatory trial of prasugrel versus clopidogrel in Japanese patients with non-cardioembolic stroke: rationale and study design for a randomized controlled trial - PRASTRO-I trial. 査読国際誌

Nagao T, Toyoda K, Kitagawa K, Kitazono T, Yamagami H, Uchiyama S, Tanahashi N, Matsumoto M, Minematsu K, Nagata I, Nishikawa M, Nanto S, Abe K, Ikeda Y, Ogawa A.

Expert Opin Pharmacother. 2018年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Outcome Prediction in Acute Stroke Patients by Continuous Glucose Monitoring. 査読国際誌

Wada S, Yoshimura S, Inoue M, Matsuki T, Arihiro S, Koga M, Kitazono T, Makino H, Hosoda K, Ihara M, Toyoda K.

J Am Heart Assoc. 2018年4月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
An improved inverse-type Ca2+ indicator can detect putative neuronal inhibition in Caenorhabditis elegans by increasing signal intensity upon Ca2+ decrease. 査読国際誌

Hara-Kuge S, Nishihara T, Matsuda T, Kitazono T, Teramoto T, Nagai T, Ishihara T.

PLoS One. 2018年4月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Incidence of diabetic foot ulcer in Japanese patients with type 2 diabetes mellitus: The Fukuoka diabetes registry. 査読国際誌

Iwase M, Fujii H, Nakamura U, Ohkuma T, Ide H, Jodai-Kitamura T, Sumi A, Komorita Y, Yoshinari M, Kitazono T

Diabetes Res Clin Pract 2018年3月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Comparing intracerebral hemorrhages associated with direct oral anticoagulants or warfarin. 査読国際誌

Kurogi R, Nishimura K, Nakai M, Kada A, Kamitani S, Nakagawara J, Toyoda K, Ogasawara K, Ono J, Shiokawa Y, Aruga T, Miyachi S, Nagata I, Matsuda S, Yoshimura S, Okuchi K, Suzuki A, Nakamura F, Onozuka D, Ido K, Kurogi A, Mukae N, Nishimura A, Arimura K, Kitazono T, Hagihara A, Iihara K; J-ASPECT Study Collaborators.

Neurology. 2018年3月

　詳細を見る

記述言語：日本語掲載種別：研究論文（学術雑誌）
Management of patients on antithrombotic agents undergoing emergency and elective endoscopy: joint Asian Pacific Association of Gastroenterology (APAGE) and Asian Pacific Society for Digestive Endoscopy (APSDE) practice guidelines. 査読国際誌

Chan FKL, Goh KL, Reddy N, Fujimoto K, Ho KY, Hokimoto S, Jeong YH, Kitazono T, Lee HS, Mahachai V, Tsoi KKF, Wu MS, Yan BP, Sugano K.

Gut. 2018年3月

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記述言語：日本語掲載種別：研究論文（学術雑誌）
Design and baseline characteristics of the Xarelto Post-Authorization Safety & Effectiveness Study in Japanese Patients with Atrial Fibrillation (XAPASS). 査読国際誌

Ogawa S, Minematsu K, Ikeda T, Kitazono T, Nakagawara J, Miyamoto S, Murakawa Y, Ohashi Y, Takeichi M, Okayama Y, Yamanaka S, Inuyama L

J Arrhythm 2018年2月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Association of geriatric nutritional risk index with infection-related mortality in patients undergoing hemodialysis: The Q-Cohort Study. 査読国際誌

Matsukuma Y, Tanaka S, Taniguchi M, Nakano T, Masutani K, Hirakata H, Kitazono T, Tsuruya K

Clin Nutr 2018年2月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Impact of obstructive sleep apnea on blood pressure and cardiovascular risk factors in Japanese men: A cross-sectional study in work-site group. 査読国際誌

Morinaga Y, Matsumura K, Kansui Y, Sakata S, Goto K, Haga Y, Oishi E, Seki T, Ohtsubo T, Kitazono T

Clin Exp Hypertens 2018年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi. 査読国際誌

Shijo M, Honda H, Suzuki SO, Hamasaki H, Hokama M, Abolhassani N, Nakabeppu Y, Ninomiya T, Kitazono T, Iwaki T

Brain Pathol 2018年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Incidence of Hepatitis B Viral Reactivation After Kidney Transplantation With Low-Dose Rituximab Administration. 査読国際誌

Masutani K, Omoto K, Okumi M, Okabe Y, Shimizu T, Tsuruya K, Kitazono T, Nakamura M, Ishida H, Tanabe K; Japan Academic Consortium of Kidney Transplantation (JACK) Investigators

Transplantation 2018年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Impact of obstructive sleep apnea on blood pressure and cardiovascular risk factors in Japanese men: A cross-sectional study in work-site group. 査読国際誌

Morinaga Y, Matsumura K, Kansui Y, Sakata S, Goto K, Haga Y, Oishi E, Seki T, Ohtsubo T, Kitazono T

Clin Exp Hypertens 2018年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Albuminuria Increases the Risks for Both Alzheimer Disease and Vascular Dementia in Community-Dwelling Japanese Elderly: The Hisayama Study. 査読国際誌

Takae K, Hata J, Ohara T, Yoshida D, Shibata M, Mukai N, Hirakawa Y, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T

J Am Heart Assoc 2018年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Endothelium-Dependent Hyperpolarization (EDH) in Hypertension: The Role of Endothelial Ion Channels. 査読国際誌

Goto K, Ohtsubo T, Kitazono T

Int J Mol Sci 2018年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi. 査読国際誌

Shijo M, Honda H, Suzuki SO, Hamasaki H, Hokama M, Abolhassani N, Nakabeppu Y, Ninomiya T, Kitazono T, Iwaki T

Brain Pathol 2018年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Role of renin-angiotensin aldosterone system on short-term blood pressure variability in hypertensive patients. 査読国際誌

Inoue M, Matsumura K, Haga Y, Kansui Y, Goto K, Ohtsubo T, Kitazono T

Clin Exp Hypertens 2017年12月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Clinical characteristics of type A acute aortic dissection with CNS symptom. 査読国際誌

Shono Y, Akahoshi T, Mezuki S, Momii K, Kaku N, Maki J, Tokuda K, Ago T, Kitazono T, Maehara Y

Am J Emerg Med 2017年12月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
The ratio of serum eicosapentaenoic acid to arachidonic acid and riskﾂof cancer death in a Japanese community: The Hisayama Study. 査読国際誌

2017年12月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Association between the maximal distance of atrial septal protrusion and cryptogenic stroke. 査読国際誌

Tokunaga K, Yasaka M, Kuwashiro T, Gotoh S, Nakamura A, Takaguchi G, Ago T, Kamouchi M, Kitazono T, Okada Y

Int J Stroke 2017年12月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Vascular endothelial growth factor-C ameliorates renal interstitial fibrosis through lymphangiogenesis in mouse unilateral ureteral obstruction. 査読国際誌

Hasegawa S, Nakano T, Torisu K, Tsuchimoto A, Eriguchi M, Haruyama N, Masutani K, Tsuruya K, Kitazono T

Lab Invest 2017年12月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
The gene-treatment interaction of paraoxonase-1 gene polymorphism and statin therapy on insulin secretion in Japanese patients with type 2 diabetes: Fukuoka diabetes registry. 査読国際誌

Sumi A, Nakamura U, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Komorita Y, Yoshinari M, Hirakawa Y, Hirano A, Kubo M, Kitazono T

BMC Med Genet 2017年12月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Isolated and repeated stroke-like episodes in a middle-aged man with a mitochondrial ND3 T10158C mutation: a case report. 査読国際誌

Mezuki S, Fukuda K, Matsushita T, Fukushima Y, Matsuo R, Goto YI, Yasukawa T, Uchiumi T, Kang D, Kitazono T, Ago T

BMC Neurol 2017年12月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Impact of blood urea nitrogen to creatinine ratio on mortality and morbidity in hemodialysis patients: The Q-Cohort Study. 査読国際誌

Tanaka S, Ninomiya T, Taniguchi M, Tokumoto M, Masutani K, Ooboshi H, Kitazono T, Tsuruya K

Sci Rep 2017年11月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Asymptomatic Brain Edema after Hemodialysis Initiation in a Patient with Severe Uremia. 査読国際誌

Fujisaki K, Nakagawa K, Nagae H, Nakano T, Taniguchi M, Masutani K, Kitazono T, Tsuruya K

Case Rep Med 2017年11月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Association of Airflow Limitation With Carotid Atherosclerosis in a Japanese Community- The Hisayama Study. 査読国際誌

Kudo K, Hata J, Matsumoto K, Shundo Y, Fukuyama S, Inoue H, Kitazono T, Kiyohara Y, Ninomiya T, Nakanishi Y

Circ J 2017年11月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Association of Hypertriglyceridemia With the Incidence and Progression of Chronic Kidney Disease and Modification of the Association by Daily Alcohol Consumption. 査読国際誌

Tsuruya K, Yoshida H, Nagata M, Kitazono T, Iseki K, Iseki C, Fujimoto S, Konta T, Moriyama T, Yamagata K, Narita I, Kimura K, Kondo M, Asahi K, Ohashi Y, Watanabe T

J Ren Nutr 2017年11月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
White-coat and masked hypertension are associated with albuminuria in a general population: the Hisayama Study. 査読国際誌

Hata J, Fukuhara M, Sakata S, Arima H, Hirakawa Y, Yonemoto K, Mukai N, Kitazono T, Kiyohara Y, Ninomiya T

Hypertens Res 2017年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Autophagy promotes degradation of internalized collagen and regulates distribution of focal adhesions to suppress cell adhesion. 査読国際誌

Kawano S, Torisu T, Esaki M, Torisu K, Matsuno Y, Kitazono T

Biol Open 2017年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Association between serum uric acid level and renal arteriolar hyalinization in individuals without chronic kidney disease. 査読国際誌

Matsukuma Y, Masutani K, Tanaka S, Tsuchimoto A, Haruyama N, Okabe Y, Nakamura M, Tsuruya K, Kitazono T

Atherosclerosis 2017年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）
A Case of Recurrent Ischemic Stroke due to Intravascular Lymphomatosis, Undiagnosed by Random Skin Biopsy and Brain Imaging. 査読国際誌

Ohya Y, Osaki M, Sakai S, Kimura S, Shimogamo T, Ago T, Kitazono T, Arakawa S

Case Rep Neurol 182 2017年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Association between responsiveness to methoxy polyethylene glycol-epoetin beta and renal survival in patients with non-dialysis-dependent chronic kidney disease: A pooled analysis of individual patient-level data from clinical trials. 査読国際誌

Tsuruya K, Uemura Y, Hirakata H, Kitazono T, Tsubakihara Y, Suzuki M, Ohashi Y

Nephrology (Carlton) 2017年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Morning and Evening Blood Pressures Are Associated With Intima-Media Thickness in a General Population縲- The Hisayama Study. 査読国際誌

2017年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Serum adiponectin predicts fracture risk in individuals with type 2 diabetes: the Fukuoka Diabetes Registry. 査読国際誌

Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Sumi A, Yoshinari M, Nakamura U, Kang D, Kitazono T

Diabetologia 2017年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Multiple Signaling Pathways Coordinately Regulate Forgetting of Olfactory Adaptation through Control of Sensory Responses in Caenorhabditis elegans. 査読国際誌

Kitazono T, Hara-Kuge S, Matsuda O, Inoue A, Fujiwara M, Ishihara T

J Neurosci 2017年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）
NADPH Oxidase-Related Pathophysiology in Experimental Models of Stroke. 査読国際誌

Yao H, Ago T, Kitazono T, Nabika T

Int J Mol 2017年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Angiotensin II Receptor-Neprilysin Inhibitor Sacubitril/Valsartan Improves Endothelial Dysfunction in Spontaneously Hypertensive Rats. 査読国際誌

Seki T, Goto K, Kansui Y, Ohtsubo T, Matsumura K, Kitazono T

J Am Heart Assoc 2017年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Repeated Paradoxical Brain Infarctions in a Patient on Self-Managed Home Hemodialysis Using a Long-Term Indwelling Catheter. 査読国際誌

Kiyohara T, Mizoguchi T, Kuroda J, Wakisaka Y, Irie A, Kitaoka C, Fujisaki K, Nakamura U, Tsuruya K, Kitazono T, Ago T

J Stroke Cerebrovasc Dis 2017年9月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Characteristics of Primary and Metachronous Gastric Cancers Discovered after Helicobacter pylori Eradication: A Multicenter Propensity Score-Matched Study. 査読国際誌

Maehata Y, Nakamura S, Esaki M, Ikeda F, Moriyama T, Hida R, Washio E, Umeno J, Hirahashi M, Kitazono T, Matsumoto T

Gut Liver 2017年9月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Comparison of Prognostic Values of Daytime and Night-Time Systolic Blood Pressures on Renal Outcomes in Patients With Chronic Kidney Disease. 査読国際誌

Katafuchi E, Nakayama M, Tanaka S, Sakoh T, Yoshitomi R, Fukui A, Seki M, Nakamata Y, Tominaga M, Tsuruya K, Kitazono T

Circ J 2017年9月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Disruption of xanthine oxidoreductase gene attenuates renal ischemia reperfusion injury in mice. 査読国際誌

Haga Y, Ohtsubo T, Murakami N, Noguchi H, Kansui Y, Goto K, Matsumura K, Kitazono T

Life Sci 182 73 - 79 2017年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）
The potential role of perivascular lymphatic vessels in preservation of kidney allograft function. 査読国際誌

Tsuchimoto A, Nakano T, Hasegawa S, Masutani K, Matsukuma Y, Eriguchi M, Nagata M, Nishiki T, Kitada H, Tanaka M, Kitazono T, Tsuruya K

Clin Exp Nephrol 2017年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Association Between Serum Vitamin D and All-Cause and Cause-Specific Death in a General Japanese Population縲- The Hisayama Study. 査読国際誌

2017年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Modified Creatinine Index and the Risk of Bone Fracture in Patients Undergoing Hemodialysis: The Q-Cohort Study. 査読国際誌

Yamada S, Taniguchi M, Tokumoto M, Yoshitomi R, Yoshida H, Tatsumoto N, Hirakata H, Fujimi S, Kitazono T, Tsuruya K

Am J Kidney Dis 2017年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）
The influence of CYP2C19 polymorphisms on exacerbating effect of rabeprazole in celecoxib-induced small bowel injury. 査読国際誌

Nuki Y, Umeno J, Washio E, Maehata Y, Hirano A, Miyazaki M, Kobayashi H, Kitazono T, Matsumoto T, Esaki M

Aliment Pharmacol Ther 2017年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Alternative Measures of Hyperglycemia and Risk of Alzheimer's Disease in the Community: The Hisayama Study. 査読国際誌

Mukai N, Ohara T, Hata J, Hirakawa Y, Yoshida D, Kishimoto H, Koga M, Nakamura U, Kitazono T, Kiyohara Y, Ninomiya T

J Clin Endocrinol Metab 2017年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Left Atrial Size and Long-Term Risk of Recurrent Stroke After Acute Ischemic Stroke in Patients With Nonvalvular Atrial Fibrillation. 査読国際誌

Ogata T, Matsuo R, Kiyuna F, Hata J, Ago T, Tsuboi Y, Kitazono T, Kamouchi M, FSR Investigators

J Am Heart Assoc 2017年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Serum Non-High-Density Lipoprotein Cholesterol and Risk of Cardiovascular Disease in Community Dwellers with Chronic Kidney Disease: the Hisayama Study. 査読国際誌

Usui T, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Kitazono T, Kiyohara Y, Ninomiya T

24 2017年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Cardiothoracic Ratio and All-Cause Mortality and Cardiovascular Disease Events in Hemodialysis Patients: The Q-Cohort Study. 査読国際誌

Yotsueda R, Taniguchi M, Tanaka S, Eriguchi M, Fujisaki K, Torisu K, Masutani K, Hirakata H, Kitazono T, Tsuruya K.

70 2017年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Dietary Protein Intake and Stroke Risk in a General Japanese Population: The Hisayama Study. 査読国際誌

Ozawa M, Yoshida D, Hata J, Ohara T, Mukai N, Shibata M, Uchida K, Nagata M, Kitazono T, Kiyohara Y, Ninomiya T

48 2017年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Comparison of cystatin C- and creatinine-based estimated glomerular filtration rates for predicting all-cause mortality in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry. 査読国際誌

Ide H, Iwase M, Fujii H, Ohkuma T, Kaizu S, Jodai T, Kikuchi Y, Idewaki Y, Sumi A, Nakamura U, Kitazono T

Clin Exp Nephrol 2017年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）
The Fukuoka Kidney disease Registry (FKR) Study: design and methods. 査読国際誌

Tanaka S, Ninomiya T, Fujisaki K, Yoshida H, Nagata M, Masutani K, Tokumoto M, Mitsuiki K, Hirakata H, Fujimi S, Kiyohara Y, Kitazono T, Tsuruya K; Fukuoka Kidney disease Registry (FKR) Study Collaboration Group

21 2017年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Comparison of cystatin C- and creatinine-based estimated glomerular filtration rates for predicting all-cause mortality in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry. 査読国際誌

Ide H, Iwase M, Fujii H, Ohkuma T, Kaizu S, Jodai T, Kikuchi Y, Idewaki Y, Sumi A, Nakamura U, Kitazono T

21 2017年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Histological Analysis in ABO-Compatible and ABO-Incompatible Kidney Transplantation by Performance of 3- and 12-Month Protocol Biopsies. 査読国際誌

Masutani K, Tsuchimoto A, Kurihara K, Okabe Y, Kitada H, Okumi M, Tanabe K, Nakamura M, Kitazono T, Tsuruya K; Japan Academic Consortium of Kidney Transplantation (JACK) investigators

101 2017年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Dura mater graft-associated Creutzfeldt-Jakob disease with 30-year incubation period. 査読国際誌

Shijo M, Honda H, Koyama S, Ishitsuka K, Maeda K, Kuroda J, Tanii M, Kitazono T, Iwaki T

37 2017年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Trends in dementia prevalence, incidence, and survival rate in a Japanese community. 査読国際誌

Ohara T, Hata J, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y, Ninomiya T

88 2017年5月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Trends in dementia prevalence, incidence, and survival rate in a Japanese community. 査読国際誌

Ohara T, Hata J, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y, Ninomiya T

Neurology 2017年5月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Clinicopathological significance of monoclonal IgA deposition in patients with IgA nephropathy. 査読国際誌

Nagae H, Tsuchimoto A, Tsuruya K, Kawahara S, Shimomura Y, Noguchi H, Masutani K, Katafuchi R, Kitazono T

21 2017年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Duodenal Neoplasms of Gastric Phenotype: An Immunohistochemical and Genetic Study With a Practical Approach to the Classification. 査読国際誌

Hida R, Yamamoto H, Hirahashi M, Kumagai R, Nishiyama K, Gi T, Esaki M, Kitazono T, Oda Y

41 2017年3月

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記述言語：英語掲載種別：研究論文（学術雑誌）
A J-shaped association between serum uric acid levels and poor renal survival in female patients with IgA nephropathy. 査読国際誌

Matsukuma Y, Masutani K, Tanaka S, Tsuchimoto A, Fujisaki K, Torisu K, Katafuchi R, Hirakata H, Tsuruya K, Kitazono T

40 2017年3月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Total Phosphate Elimination is Negatively Associated With Increased Serum Fibroblast Growth Factor 23 Levels in Patients who Undergo Peritoneal Dialysis. 査読国際誌

Yamada S, Tsuruya K, Tokumoto M, Yoshida H, Tatsumoto N, Ooboshi H, Kitazono T

21 2017年2月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Genetic Predisposition to Ischemic Stroke: A Polygenic Risk Score. 査読国際誌

Hachiya T, Kamatani Y, Takahashi A, Hata J, Furukawa R, Shiwa Y, Yamaji T, Hara M, Tanno K, Ohmomo H, Ono K, Takashima N, Matsuda K, Wakai K, Sawada N, Iwasaki M, Yamagishi K, Ago T, Ninomiya T, Fukushima A, Hozawa A, Minegishi N, Satoh M, Endo R, Sasaki M, Sakata K, Kobayashi S, Ogasawara K, Nakamura M, Hitomi J, Kita Y, Tanaka K, Iso H, Kitazono T, Kubo M, Tanaka H, Tsugane S, Kiyohara Y, Yamamoto M, Sobue K, Shimizu A

48 2017年2月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Adverse Influence of Pre-Stroke Dementia on Short-Term Functional Outcomes in Patients with Acute Ischemic Stroke: The Fukuoka Stroke Registry. 査読国際誌

Wakisaka Y, Matsuo R, Hata J, Kuroda J, Kitazono T, Kamouchi M, Ago T; Fukuoka Stroke Registry Investigators.

43 2017年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Modified Simple Peritoneal Wall Anchor Technique (PWAT) in Peritoneal Dialysis. 査読国際誌

Oka H, Yamada S, Kamimura T, Hara M, Hirashima Y, Matsueda S, Shukuri T, Aihara S, Koresawa M, Eriguchi M, Harada A, Tsuruya K, Kitazono T

37 2017年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway. 査読国際誌

108 2017年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Cerebral Venous Thrombosis in the Superior Sagittal Sinus as a Rare Cause of a Paroxysmal Kinetic Tremor. 査読国際誌

Murao K, Arakawa S, Furuta Y, Shijo M, Ago T, Kitazono T

8 2017年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Combination of Helicobacter pylori Antibody and Serum Pepsinogen as a Good Predictive Tool of Gastric Cancer Incidence: 20-Year Prospective Data From the Hisayama Study. 査読国際誌

Ikeda F, Shikata K, Hata J, Fukuhara M, Hirakawa Y, Ohara T, Mukai N, Nagata M, Yoshida D, Yonemoto K, Esaki M, Kitazono T, Kiyohara Y, Ninomiya T

26 2016年12月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Comparison of steroid-pulse therapy and combined with mizoribine in IgA nephropathy: a randomized controlled trial. 査読国際誌

Masutani K, Tsuchimoto A, Yamada T, Hirakawa M, Mitsuiki K, Katafuchi R, Hirakata H, Kitazono T, Tsuruya K; West Japan Study Group for Therapy of IgA Nephropathy Investigators

20 2016年12月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Inhibition of GSK-3β increases trabecular bone volume but not cortical bone volume in adenine-induced uremic mice with severe hyperparathyroidism. 査読国際誌

4 2016年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Associations of fibroblast growth factor 23 with urate metabolism in patients with chronic kidney disease. 査読国際誌

Sakoh T, Nakayama M, Tsuchihashi T, Yoshitomi R, Tanaka S, Katafuchi E, Fukui A, Shikuwa Y, Anzai N, Kitazono T, Tsuruya K

65 2016年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）
The effect of renin-angiotensin system blockade on the incidence of end-stage renal disease in IgA nephropathy. 査読国際誌

Tanaka S, Ninomiya T, Katafuchi R, Masutani K, Nagata M, Tsuchimoto A, Hirakata H, Kitazono T, Tsuruya K

20 2016年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Effects of smoking and its cessation on creatinine- and cystatin C-based estimated glomerular filtration rates and albuminuria in male patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry. 査読国際誌

Ohkuma T, Nakamura U, Iwase M, Ide H, Fujii H, Jodai T, Kaizu S, Kikuchi Y, Idewaki Y, Sumi A, Hirakawa Y, Kitazono T

39 2016年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）
PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice. 査読国際誌

21 2016年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Association Between Serum Phosphate Levels and Stroke Risk in Patients Undergoing Hemodialysis: The Q-Cohort Study. 査読国際誌

Yamada S, Tsuruya K, Taniguchi M, Tokumoto M, Fujisaki K, Hirakata H, Fujimi S, Kitazono T.

Stroke 49 2016年9月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Salt Intake, Home Blood Pressure, and Perinatal Outcome in Pregnant Women. 査読国際誌

Inoue M, Tsuchihashi T, Hasuo Y, Ogawa M, Tominaga M, Arakawa K, Oishi E, Sakata S, Ohtsubo T, Matsumura K, Kitazono T

80 2016年9月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Association Between Diabetes and Hippocampal Atrophy in Elderly Japanese: The Hisayama Study. 査読国際誌

Hirabayashi N, Hata J, Ohara T, Mukai N, Nagata M, Shibata M, Gotoh S, Furuta Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Kiyohara Y, Ninomiya T.

Diabetes Care 39 2016年9月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Serum Angiopoietin-Like Protein 2 Is a Novel Risk Factor for Cardiovascular Disease in the Community: The Hisayama Study. 査読国際誌

Hata J, Mukai N, Nagata M, Ohara T, Yoshida D, Kishimoto H, Shibata M, Hirakawa Y, Endo M, Ago T, Kitazono T, Oike Y, Kiyohara Y, Ninomiya T.

Arterioscler Thromb Vasc Biol 36 2016年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Diagnosis and follow-up of posterior inferior cerebellar artery dissection complicated with ischemic stroke assisted by T1-VISTA: a report of two cases. 査読国際誌

Ishitsuka K, Sakaki Y, Sakai S, Uwatoko T, Aibe H, Ago T, Kitazono T, Sugimori H.

BMC Neurol 16 2016年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Serum Uric Acid as a Risk Factor for Chronic Kidney Disease in a Japanese Community - The Hisayama Study. 査読国際誌

Takae K, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T

80 2016年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Anti-Cyclic Citrullinated Peptide Antibody-Positive Meningoencephalitis in the Preclinical Period of Rheumatoid Arthritis. 査読国際誌

Shibahara T, Matsushita T, Matsuo R, Fukushima Y, Fukuda K, Sugimori H, Kamouchi M, Kitazono T, Ago T

8 2016年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Genetic characteristics of inflammatory bowel disease in a Japanese population. 査読国際誌

Fuyuno Y, Yamazaki K, Takahashi A, Esaki M, Kawaguchi T, Takazoe M, Matsumoto T, Matsui T, Tanaka H, Motoya S, Suzuki Y, Kiyohara Y, Kitazono T, Kubo M.

J Gastroenterol 51 2016年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Factors Associated with the Serum Myostatin Level in Patients Undergoing Peritoneal Dialysis: Potential Effects of Skeletal Muscle Mass and Vitamin D Receptor Activator Use. 査読国際誌

Yamada S, Tsuruya K, Yoshida H, Tokumoto M, Ueki K, Ooboshi H, Kitazono T.

Calcif Tissue Int 99 2016年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Three-month risk-benefit profile of anticoagulation after stroke with atrial fibrillation: The SAMURAI-Nonvalvular Atrial Fibrillation (NVAF) study. 査読国際誌

Arihiro S, Todo K, Koga M, Furui E, Kinoshita N, Kimura K, Yamagami H, Terasaki T, Yoshimura S, Shiokawa Y, Kamiyama K, Takizawa S, Okuda S, Okada Y, Nagakane Y, Kameda T, Hasegawa Y, Shibuya S, Ito Y, Nakashima T, Takamatsu K, Nishiyama K, et al.

Int J Stroke 11 2016年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Comparison of oral versus intravenous vitamin D receptor activator in reducing infection-related mortality in hemodialysis patients: the Q-Cohort Study. 査読国際誌

Tanaka S, Ninomiya T, Taniguchi M, Fujisaki K, Tokumoto M, Hirakata H, Ooboshi H, Kitazono T, Tsuruya K.

Nephrol Dial Transplant. 31 2016年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Influence of Statin Pretreatment on Initial Neurological Severity and Short-Term Functional Outcome in Acute Ischemic Stroke Patients: The Fukuoka Stroke Registry. 査読国際誌

Ishikawa H, Wakisaka Y, Matsuo R, Makihara N, Hata J, Kuroda J, Ago T, Kitayama J, Nakane H, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators.

Cerebrovasc Dis 42 2016年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）
The Successful Treatment of Calciphylaxis with Sodium Thiosulfate and Hyperbaric Oxygen in a Non-dialyzed Patient with Chronic Kidney Disease. 査読国際誌

Aihara S, Yamada S, Uchida Y, Arase H, Tsuchimoto A, Nakano T, Taniguchi M, Higashi H, Kitazono T, Tsuruya K.

Intern Med 55 2016年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Plasma C-Reactive Protein and Clinical Outcomes after Acute Ischemic Stroke: A Prospective Observational Study. 査読国際誌

Matsuo R, Ago T, Hata J, Wakisaka Y, Kuroda J, Kuwashiro T, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators.

PLoS One 11 2016年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Proton Pump Inhibitors Increase Incidence of Nonsteroidal Anti-Inflammatory Drug-Induced Small Bowel Injury: AﾂRandomized, Placebo-Controlled Trial. 査読国際誌

14 2016年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Detrimental role of pericyte Nox4 in the acute phase of brain ischemia. 査読国際誌

Nishimura A, Ago T, Kuroda J, Arimura K, Tachibana M, Nakamura K, Wakisaka Y, Sadoshima J, Iihara K, Kitazono T.

J Cereb Blood Flow Metab 36 2016年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Comparison of the therapeutic efficacy and safety between tacrolimus and infliximab for moderate-to-severe ulcerative colitis: a single center experience. 査読国際誌

Nuki Y, Esaki M, Asano K, Maehata Y, Umeno J, Moriyama T, Nakamura S, Matsumoto T, Kitazono T.

Scand J Gastroenterol 51 2016年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Light Chain Deposition Disease in an Older Adult Patient Successfully Treated with Long-term Administration of Bortezomib, Melphalan and Prednisone. 査読国際誌

Hiyamuta H, Yamada S, Matsukuma Y, Tsuchimoto A, Nakano T, Taniguchi M, Masutani K, Yoshimoto G, Muta T, Akashi K, Kitazono T, Tsuruya K.

Intern Med 55 2016年5月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Subacute pulmonary embolism in a hemodialysis patient, successfully treated with surgical thrombectomy. 査読国際誌

Yamasaki K, Haruyama N, Taniguchi M, Nishida T, Tominaga R, Kitazono T, Tsuruya K

5 2016年5月

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記述言語：英語掲載種別：研究論文（学術雑誌）
[Pathogenetic mechanism of brain infarction]. 査読国際誌

Kitazono T.

Nihon Rinsho 74 2016年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Extended Swan-Neck Catheter With Upper Abdominal Exit-Site Reduces Peritoneal Dialysis-Related Infections. 査読国際誌

Eriguchi M, Tsuruya K, Yoshida H, Haruyama N, Tanaka S, Tsuchimoto A, Fujisaki K, Torisu K, Masutani K, Kitazono T.

Ther Apher Dial 20 2016年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Plasma B-type natriuretic peptide concentration is independently associated with kidney function decline in Japanese patients with chronic kidney disease. 査読国際誌

Yoshitomi R, Nakayama M, Sakoh T, Fukui A, Shikuwa Y, Tominaga M, Tsuchihashi T, Tsuruya K, Kitazono T.

J Hypertens 34 2016年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Influenza Vaccination and Other Factors Related to the Development of Influenza-Like Illness Among Patients on Chronic Hemodialysis in a Japanese Dialysis Facility. 査読国際誌

Washio M, Higashi H, Sugawara K, Tsusumi C, Sakita M, Ide Y, Tsuruya K, Kitazono T, Kondo K, Ide S.

Ther Apher Dial 20 2016年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Causes of Ischemic Stroke in Patients with Non-Valvular Atrial Fibrillation. 査読国際誌

Nakamura A, Kuroda J, Ago T, Hata J, Matsuo R, Arakawa S, Kuwashiro T, Yasaka M, Okada Y, Kitazono T, Kamouchi M; Fukuoka Stroke Registry Investigators.

Cerebrovasc Dis 42 2016年4月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Trends in blood pressure control and medication use during 20 years in a hypertension clinic in Japan. 査読国際誌

Kansui Y, Ibaraki A, Goto K, Haga Y, Seki T, Takiguchi T, Ohtsubo T, Kitazono T, Matsumura K.

Clin Exp Hypertens 38 2016年3月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Erythropoiesis-stimulating agent slows the progression of chronic kidney disease: a possibility of a direct action of erythropoietin. 査読国際誌

Tsuruya K, Yoshida H, Suehiro T, Fujisaki K, Masutani K, Kitazono T.

Ren Fail 38 2016年3月

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記述言語：英語掲載種別：研究論文（学術雑誌）
The long-term association between physical activity and risk of dementia in the community: the Hisayama Study. 査読国際誌

Kishimoto H, Ohara T, Hata J, Ninomiya T, Yoshida D, Mukai N, Nagata M, Ikeda F, Fukuhara M, Kumagai S, Kanba S, Kitazono T, Kiyohara Y.

Eur J Epidemiol 31 2016年3月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Very low protein diet enhances inflammation, malnutrition, and vascular calcification in uremic rats. 査読国際誌

Yamada S, Tokumoto M, Tatsumoto N, Tsuruya K, Kitazono T, Ooboshi H.

Life Sci 146 2016年2月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Effects of Lowering Dialysate Calcium Concentration on Mineral and Bone Disorders in Chronic Hemodialysis Patients: Conversion from 3.0 mEq/L to 2.75 mEq/L. 査読国際誌

20 2016年2月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Hypoalbuminemia, influenza vaccination and other factors related to the development of pneumonia acquired outside hospitals in southern Japan: A case-control study. 査読国際誌

Washio M, Kondo K, Fujisawa N, Harada E, Tashiro H, Mizokami T, Nogami H, Iwanaga T, Nakanishi Y, Suzuki K, Ohfuji S, Fukushima W, Hirota Y; Kyushu Task Force for CAP Risk in the Elderly.

Geriatr Gerontol Int 16 2016年2月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Assessment of urinary angiotensinogen as a marker of podocyte injury in proteinuric nephropathies. 査読国際誌

Eriguchi M, Yotsueda R, Torisu K, Kawai Y, Hasegawa S, Tanaka S, Noguchi H, Masutani K, Kitazono T, Tsuruya K.

Am J Physiol Renal Physiol 310 2016年2月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Prognostic value of chromosomal translocations in small-bowel diffuse large B-cell lymphoma. 査読国際誌

Ikegami K, Nakamura S, Esaki M, Yanai S, Hirahashi M, Oda Y, Takeshita M, Matsumoto T, Kitazono T

Histopathology 68 199 - 209 2016年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Prognostic value of chromosomal translocations in small-bowel diffuse large B-cell lymphoma. 査読国際誌

Ikegami K, Nakamura S, Esaki M, Yanai S, Hirahashi M, Oda Y, Takeshita M, Matsumoto T, Kitazono T.

Histopathology 68 2016年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Possible involvement of basic FGF in the upregulation of PDGFRﾎｲ in pericytes after ischemic stroke. 査読国際誌

1630 2016年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
[Intravascular Large B Cell Lymphoma with Cauda Equina Syndrome: A Case Report and Review of the Literature]. 査読国際誌

Wada S, Matsuo R, Matsushita T, Fukushima Y, Ago T, Kitazono T.

Brain Nerve 68 2016年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Prognostic impact of serum bilirubin level on long-term renal survival in IgA nephropathy. 査読国際誌

Tanaka S, Ninomiya T, Masutani K, Nagata M, Tsuchimoto A, Tsuruya K, Kitazono T

19 2015年12月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Spironolactone ameliorates arterial medial calcification in uremic rats: the role of mineralocorticoid receptor signaling in vascular calcification. 査読国際誌

Tatsumoto N, Yamada S, Tokumoto M, Eriguchi M, Noguchi H, Torisu K, Tsuruya K, Kitazono T

309 2015年12月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Clinical significance of fronto-temporal gray matter atrophy in executive dysfunction in patients with chronic kidney disease: the VCOHP Study. 査読国際誌

Tsuruya K, Yoshida H, Haruyama N, Fujisaki K, Hirakata H, Kitazono T

10 2015年12月

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記述言語：英語掲載種別：研究論文（学術雑誌）
A multicenter, prospective, observational study of warfarin-associated intracerebral hemorrhage: The SAMURAI-WAICH study. 査読国際誌

Osaki M, Koga M, Maeda K, Hasegawa Y, Nakagawara J, Furui E, Todo K, Kimura K, Shiokawa Y, Okada Y, Okuda S, Kario K, Yamagami H, Minematsu K, Kitazono T, Toyoda K, et al.

359 2015年12月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Impact of the Triglycerides to High-Density Lipoprotein Cholesterol Ratio on the Incidence and Progression of CKD: A Longitudinal Study in a Large Japanese Population. 査読国際誌

Tsuruya K, Yoshida H, Nagata M, Kitazono T, Iseki K, Iseki C, Fujimoto S, Konta T, Moriyama T, Yamagata K, Narita I, Kimura K, Kondo M, Asahi K, Kurahashi I, Ohashi Y, Watanabe T

66 2015年12月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Association between eating rate and obesity: a systematic review and meta-analysis. 査読国際誌

Ohkuma T, Hirakawa Y, Nakamura U, Kiyohara Y, Kitazono T, Ninomiya T

39 2015年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）
A hereditary enteropathy caused by mutations in the SLCO2A1 gene, encoding a prostaglandin transporter. 査読国際誌

Umeno J, Hisamatsu T, Esaki M, Hirano A, Kubokura N, Asano K, Kochi S, Yanai S, Fuyuno Y, Shimamura K, Hosoe N, Ogata H, Watanabe T, Aoyagi K, Watanabe K, Yasukawa S, Hirai F, Matsui T, Iida M, Yao T, Hibi T, Kosaki K, Kanai T, Kitazono T, Matsumoto T

11 2015年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Association of genetically determined aldehyde dehydrogenase 2 Activity with diabetic complications in relation to alcohol consumption in Japanese patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry. 査読国際誌

Idewaki Y, Iwase M, Fujii H, Ohkuma T, Ide H, Kaizu S, Jodai T, Kikuchi Y, Hirano A, Nakamura U, Kubo M, Kitazono T

10 2015年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Cardiorenal syndrome in end-stage kidney disease. 査読国際誌

Tsuruya K, Eriguchi M, Yamada S, Hirakata H, Kitazono T

40 2015年11月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Midlife and late-life smoking and risk of dementia in the community: the Hisayama Study. 査読国際誌

Ohara T, Ninomiya T, Hata J, Ozawa M, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y

63 2015年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Fetuin-A decrease induced by a low protein diet enhances vascular calcification in uremic rats with hyperphosphatemia. 査読国際誌

Yamada S, Tokumoto M, Tsuruya K, Tatsumoto N, Noguchi H, Kitazono T, Ooboshi H

309 2015年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Hematocrit and the risk of cardiovascular disease in a Japanese community: the Hisayama Study. 査読国際誌

Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Ago T, Kitazono T, Kiyohara Y

242 2015年9月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Factors associated with serum soluble inhibitors of Wnt-β-catenin signaling (sclerostin and dickkopf-1) in patients undergoing peritoneal dialysis. 査読国際誌

20 2015年9月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Association of serum total bilirubin with renal outcome in Japanese patients with stages 3-5 chronic kidney disease. 査読国際誌

Sakoh T, Nakayama M, Tanaka S, Yoshitomi R, Ura Y, Nishimoto H, Fukui A, Shikuwa Y, Tsuruya K, Kitazono T

64 2015年9月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Two years of cinacalcet hydrochloride treatment decreased parathyroid gland volume and serum parathyroid hormone level in hemodialysis patients with advanced secondary hyperparathyroidism. 査読国際誌

Yamada S, Tokumoto M, Taniguchi M, Toyonaga J, Suehiro T, Eriguchi R, Fujimi S, Ooboshi H, Kitazono T, Tsuruya K

19 2015年8月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
A genome-wide association study of late-onset Alzheimer's disease in a Japanese population. 査読国際誌

Hirano A, Ohara T, Takahashi A, Aoki M, Fuyuno Y, Ashikawa K, Morihara T, Takeda M, Kamino K, Oshima E, Okahisa Y, Shibata N, Arai H, Akatsu H, Ikeda M, Iwata N, Ninomiya T, Monji A, Kitazono T, Kiyohara Y, Kubo M, Kanba S

25 2015年8月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Relationship between salt intake as estimated by a brief self-administered diet-history questionnaire (BDHQ) and 24-h urinary salt excretion in hypertensive patients. 査読国際誌

Sakata S, Tsuchihashi T, Oniki H, Tominaga M, Arakawa K, Sakaki M, Kitazono T

38 2015年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Systemic aldosterone, but not angiotensin II, plays a pivotal role in the pathogenesis of renal injury in chronic nitric oxide-deficient male rats. 査読国際誌

Suehiro T, Tsuruya K, Ikeda H, Toyonaga J, Yamada S, Noguchi H, Tokumoto M, Kitazono T

156 2015年7月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Day-by-Day Blood Pressure Variability and Functional Outcome After Acute Ischemic Stroke: Fukuoka Stroke Registry. 査読国際誌

Fukuda K, Kai H, Kamouchi M, Hata J, Ago T, Nakane H, Imaizumi T, Kitazono T; FSR Investigators; steering committee of the Fukuoka Stroke Registry included

46 2015年7月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Association of hemoglobin A1c and glycated albumin with carotid atherosclerosis in community-dwelling Japanese subjects: the Hisayama Study. 査読国際誌

Mukai N, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y

14 2015年6月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Effects of hydrochlorothiazide on oxidative stress and pulse pressure in hypertensive patients with chronic stroke: the EMINENT study. 査読国際誌

Nakane H, Kamouchi M, Hata J, Ibayashi S, Kusuda K, Omae T, Nagao T, Ago T, Kitazono T; EMINENT Study Investigators

54 2015年6月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Risk of cancer in the rectal remnant after ileorectal anastomosis in patients with familial adenomatous polyposis: single center experience. 査読国際誌

Maehata Y, Esaki M, Nakamura S, Hirahashi M, Ueki T, Iida M, Kitazono T, Matsumoto T

27 2015年5月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Association of severe hypoglycemia with depressive symptoms in patients with type 2 diabetes: the Fukuoka Diabetes Registry. 査読国際誌

Kikuchi Y, Iwase M, Fujii H, Ohkuma T, Kaizu S, Ide H, Jodai T, Idewaki Y, Nakamura U, Kitazono T

3 2015年5月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Phosphate binders prevent phosphate-induced cellular senescence of vascular smooth muscle cells and vascular calcification in a modified, adenine-based uremic rat model. 査読国際誌

Yamada S, Tatsumoto N, Tokumoto M, Noguchi H, Ooboshi H, Kitazono T, Tsuruya K

Calcif Tissue Int 96 2015年4月

　詳細を見る

掲載種別：研究論文（学術雑誌）
Clinicopathologic features of chronic nonspecific multiple ulcers of the small intestine. 査読国際誌

Esaki M, Umeno J, Kitazono T, Matsumoto T

8 2015年4月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo. 査読国際誌

Kubokura N, Takahashi-Yanaga F, Arioka M, Yoshihara T, Igawa K, Tomooka K, Morimoto S, Nakatsu Y, Tsuzuki T, Nakabeppu Y, Matsumoto T, Kitazono T, Sasaguri T

127 2015年4月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Nonconvulsive partial status epilepticus mimicking recurrent infarction revealed by diffusion-weighted and arterial spin labeling perfusion magnetic resonance images. 査読国際誌

Kanazawa Y, Morioka T, Arakawa S, Furuta Y, Nakanishi A, Kitazono T

24 2015年4月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Hyporesponsiveness to erythropoiesis-stimulating agent as a prognostic factor in Japanese hemodialysis patients: the Q-Cohort study. 査読国際誌

Eriguchi R, Taniguchi M, Ninomiya T, Hirakata H, Fujimi S, Tsuruya K, Kitazono T

28 2015年4月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Angiotensin I-converting enzyme gene polymorphism enhances the effect of hypercholesterolemia on the risk of coronary heart disease in a general Japanese population: the hisayama study. 査読国際誌

Kondo H, Ninomiya T, Hata J, Hirakawa Y, Yonemoto K, Arima H, Nagata M, Tsuruya K, Kitazono T, Kiyohara Y

J Atheroscler Thromb 22 2015年4月

　詳細を見る

掲載種別：研究論文（学術雑誌）
Sex differences in short-term outcomes after acute ischemic stroke: the fukuoka stroke registry. 査読国際誌

Irie F, Kamouchi M, Hata J, Matsuo R, Wakisaka Y, Kuroda J, Ago T, Kitazono T; FSR Investigators

Stroke 46 2015年2月

　詳細を見る

掲載種別：研究論文（学術雑誌）
Subsequent vascular events after ischemic stroke: the Japan Statin Treatment Against Recurrent Stroke-Longitudinal. 査読国際誌

Nomura E, Suzuki A, Inoue I, Nakagawara J, Takahashi K, Takahashi T, Manabe Y, Yokota C, Okada K, Nishihara T, Yamamoto Y, Noda K, Takahashi S, Ibayashi S, Takagi M, Kitagawa K, Tanahashi N, Kuriyama M, Hirata K, Hosomi N, Minematsu K, Kobayashi S, Matsumoto M; J-STARS-L Investigators

J Stroke Cerebrovasc Dis 24 2015年2月

　詳細を見る

掲載種別：研究論文（学術雑誌）
Involvement of platelet-derived growth factor receptor β in fibrosis through extracellular matrix protein production after ischemic stroke. 査読国際誌

264 2015年2月

　詳細を見る

掲載種別：研究論文（学術雑誌）
Dietary patterns and clinical outcomes in hemodialysis patients in Japan: a cohort study. 査読国際誌

Tsuruya K, Fukuma S, Wakita T, Ninomiya T, Nagata M, Yoshida H, Fujimi S, Kiyohara Y, Kitazono T, Uchida K, Shirota T, Akizawa T, Akiba T, Saito A, Fukuhara S

10 2015年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Possible involvement of basic FGF in the upregulation of PDGFRβ in pericytes after ischemic stroke. 査読国際誌

1930 2015年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Therapeutic strategy for Crohn's disease with a loss of response to infliximab: a single-center retrospective study. 査読国際誌

Nagata Y, Esaki M, Umeno J, Fuyuno Y, Ikegami K, Maehata Y, Asano K, Moriyama T, Nakamura S, Kitazono T,Matsumoto T

Digestion 91 50 - 56 2015年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Importance of specific reference values for evaluation of the deteriorating thyroid function in patients with end-stage renal disease on hemodialysis. 査読国際誌

Sanai T, Okamura K, Kishi T, Miyazono M, Ikeda Y, Kitazono T

J Endocriol Invest 38 47 - 56 2015年1月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Hypercalcemia induced by Rosai-Dorfman disease in a hemodialysis patient: histological evidence of extrarenal calcitriol overproduction. 査読国際誌

Yamada S, Uemura M, Tokumoto M, Nagara T, Noguchi H, Hirahashi M, Nakano T, Tsuruya K, Kitazono T

Intern Med 53 2014年12月

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掲載種別：研究論文（学術雑誌）
Statin inhibits the expression of secretory phospholipase A2 and subsequent monocyte chemoattractant protein-1 in human endothelial cells. 査読国際誌

Sonoki K, Iwase M, Ohdo S, Ieiri I, Takata Y, Kitazono T

J Cardiovasc Pharmacol 64 2014年12月

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掲載種別：研究論文（学術雑誌）
Intravenous thrombolysis with recombinant tissue plasminogen activator for ischemic stroke patients over 80 years old: the Fukuoka Stroke Registry. 査読国際誌

Matsuo R, Kamouchi M, Fukuda H, Hata J, Wakisaka Y, Kuroda J, Ago T, Kitazono T; FSR Investigators

PLoS One 9 2014年10月

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掲載種別：研究論文（学術雑誌）
Significance of plasma adiponectin for diagnosis, neurological severity and functional outcome in ischemic stroke - Research for Biomarkers in Ischemic Stroke (REBIOS). 査読国際誌

Kuwashiro T, Ago T, Kamouchi M, Matsuo R, Hata J, Kuroda J, Fukuda K, Sugimori H, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T

Metabolism 63 2014年9月

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掲載種別：研究論文（学術雑誌）
Gastrointestinal bleeding in acute ischemic stroke: recent trends from the fukuoka stroke registry. 査読国際誌

Ogata T, Kamouchi M, Matsuo R, Hata J, Kuroda J, Ago T, Sugimori H, Inoue T, Kitazono T; Fukuoka Stroke Registry

Cerebrovasc Dis Extra 4 2014年7月

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掲載種別：研究論文（学術雑誌）
Nox4 is a major source of superoxide production in human brain pericytes. 査読国際誌

Kuroda J, Ago T, Nishimura A, Nakamura K, Matsuo R, Wakisaka Y, Kamouchi M, Kitazono T

J Vasc Res 51 2014年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）
U-shaped association of sleep duration with metabolic syndrome and insulin resistance in patients with type 2 diabetes: the Fukuoka Diabetes Registry. 査読国際誌

Ohkuma T, Fujii H, Iwase M, Ogata-Kaizu S, Ide H, Kikuchi Y, Idewaki Y, Jodai T, Hirakawa Y, Nakamura U, Kitazono T

Metabolism 63 2014年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Cerebral oxidative stress induces spatial working memory dysfunction in uremic mice: neuroprotective effect of tempol. 査読国際誌

Fujisaki K, Tsuruya K, Yamato M, Toyonaga J, Noguchi H, Nakano T, Taniguchi M, Tokumoto M, Hirakata H, Kitazono T

Nephrol Dial Transplant 29 2014年3月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Trends in the prevalence of type 2 diabetes and prediabetes in community-dwelling Japanese subjects: The Hisayama Study. 査読国際誌

Mukai N, Doi Y, Ninomiya T, Hirakawa Y, Nagata M, Yoshida D, Hata J, Fukuhara M, Nakamura U, Kitazono T, Kiyohara Y

J Diabetes Investig 5 2014年3月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Serum 1,25-dihydroxyvitamin d and the development of kidney dysfunction in a Japanese community. 査読国際誌

Izumaru K, Ninomiya T, Nagata M, Usui T, Yoshida D, Yonemoto K, Fukuhara M, Tsuruya K, Kitazono T, Kiyohara Y

Circ J 78 2014年3月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Trends in the incidence and survival of intracerebral hemorrhage by its location in a Japanese community. 査読国際誌

Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Shikata K, Kamouchi M, Kitazono T, Kiyohara Y

Circ J 78 2014年2月

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記述言語：英語掲載種別：研究論文（学術雑誌）
ABCD3 and ABCD3-I scores are superior to ABCD2 score in the prediction of short- and long-term risks of stroke after transient ischemic attack. Stroke. 査読国際誌

Kiyohara T, Kamouchi M, Kumai Y, Ninomiya T, Hata J, Yoshimura S, Ago T, Okada Y, Kitazono T

Stroke 45 2014年2月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Statins and the risks of stroke recurrence and death after ischemic stroke: the Fukuoka Stroke Registry. 査読国際誌

Makihara N, Kamouchi M, Hata J, Matsuo R, Ago T, Kuroda J, Kuwashiro T, Sugimori H, Kitazono T; Fukuoka Stroke Registry Investigators

Atherosclerosis 231 2013年12月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Impact of dietary fiber intake on glycemic control, cardiovascular risk factors and chronic kidney disease in Japanese patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry. 査読国際誌

Fujii H, Iwase M, Ohkuma T, Ogata-Kaizu S, Ide H, Kikuchi Y, Idewaki Y, Joudai T, Hirakawa Y, Uchida K, Sasaki S, Nakamura U, Kitazono T

Nutr J 12 2013年12月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: the Hisayama Study. 査読国際誌

Ninomiya T, Nagata M, Hata J, Hirakawa Y, Ozawa M, Yoshida D, Ohara T, Kishimoto H, Mukai N, Fukuhara M, Kitazono T, Kiyohara Y

Atherosclerosis 231 2013年12月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Acute kidney injury and edaravone in acute ischemic stroke: the Fukuoka Stroke Registry. 査読国際誌

Kamouchi M, Sakai H, Kiyohara Y, Minematsu K, Hayashi K, Kitazono T

J Stroke Cerebrovasc Dis 22 2013年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Predictive role of C reactive protein in stroke recurrence after cardioembolic stroke: the Fukuoka Stroke Registry. 査読国際誌

Kuwashiro T, Sugimori H, Ago T, Kuroda J, Kamouchi M, Kitazono T; FSR Investigators

BMJ Open 3 2013年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general Japanese population: the Hisayama Study. 査読国際誌

Ikeda F, Doi Y, Ninomiya T, Hirakawa Y, Mukai N, Hata J, Shikata K, Yoshida D, Matsumoto T, Kitazono T, Kiyohara Y

Cardiovasc Diabetol 12 2013年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Association of deep venous thrombosis with calf vein diameter in acute hemorrhagic stroke. 査読国際誌

Ogata T, Yasaka M, Wakugawa Y, Kitazono T

J Stroke Cerebrovasc Dis 22 2013年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Impact of allele copy number of polymorphisms in FCGR3A and FCGR3B genes on susceptibility to ulcerative colitis. 査読国際誌

Asano K, Matsumoto T, Umeno J, Hirano A, Esaki M, Hosono N, Matsui T, Kiyohara Y, Nakamura Y, Kubo M, Kitazono T

Inflamm Bowel Dis 19 2013年9月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Angiopoietin-like protein 2 is associated with chronic kidney disease in a general Japanese population: the Hisayama Study. 査読国際誌

Usui T, Ninomiya T, Nagata M, Takahashi O, Doi Y, Hata J, Fukuhara M, Kitazono T, Oike Y, Kiyohara Y

Circ J 77 2013年9月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Progression of right internal carotid artery stenosis in ischemic stroke patient with autoimmune polyglandular syndrome: A case report. 査読国際誌

Kanazawa Y, Matsuo R, Fukushima Y, Fukuda K, Kamouchi M, Kitazono T

Rinsho Shinkeigaku 53 2013年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Slowly progressive and painless thoracic aortic dissection presenting with a persistent Fever in an elderly patient: the usefulness of combined measurement of biochemical parameters. 査読国際誌

Yamada S, Tokumoto M, Ohkuma T, Kansui Y, Wakisaka Y, Uchizono Y, Tsuruya K, Kitazono T, Ooboshi H

Case Rep Med 2013 2013年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）
The clinical utility of serum tartrate-resistant acid phosphatase 5b in the assessment of bone resorption in patients on peritoneal dialysis. 査読国際誌

Yamada S, Tsuruya K, Yoshida H, Taniguchi M, Haruyama N, Tanaka S, Eriguchi M, Nakano T, Kitazono T.

Clin Endocrinol (Oxf) 78 2013年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）
The impact of predisposing factors on long-term outcome after stroke in diabetic patients: the Fukuoka Stroke Registry. 査読国際誌

Kuwashiro T, Sugimori H, Ago T, Kuroda J, Kamouchi M, Kitazono T

Eur J Neurol 20 2013年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）
White-coat and masked hypertension are associated with carotid atherosclerosis in a general population: the Hisayama study. 査読国際誌

Fukuhara M, Arima H, Ninomiya T, Hata J, Hirakawa Y, Doi Y, Yonemoto K, Mukai N, Nagata M, Ikeda F, Matsumura K, Kitazono T, Kiyohara Y

Stroke 44 2013年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Temporal trends in sudden unexpected death in a general population: the Hisayama study. 査読国際誌

Nagata M, Ninomiya T, Doi Y, Hata J, Ikeda F, Mukai N, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y

Am Heart J 165 2013年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Regression of tumoral calcinosis after the appropriate control of a deranged mineral and bone metabolism, in conjugation with cinacalcet hydrochloride treatment, in a chronic hemodialysis patient. 査読国際誌

Yamada S, Tsuruya K, Kitazono T

Ther Apher Dial 17 2013年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Dietary patterns and risk of dementia in an elderly Japanese population: the Hisayama Study. 査読国際誌

Ozawa M, Ninomiya T, Ohara T, Doi Y, Uchida K, Shirota T, Yonemoto K, Kitazono T, Kiyohara Y

Am J Clin Nutr 97 2013年5月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Clinical significance of plasma VEGF value in ischemic stroke - research for biomarkers in ischemic stroke (REBIOS) study. 査読国際誌

Matsuo R, Ago T, Kamouchi M, Kuroda J, Kuwashiro T, Hata J, Sugimori H, Fukuda K, Gotoh S, Makihara N, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T

BMC Neurol 13 2013年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）
RANTES has a potential to play a neuroprotective role in an autocrine/paracrine manner after ischemic stroke. 査読国際誌

Tokami H, Ago T, Sugimori H, Kuroda J, Awano H, Suzuki K, Kiyohara Y, Kamouchi M, Kitazono T

Brain Res 2013年4月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Brachial-ankle pulse wave velocity predicts the development of cardiovascular disease in a general Japanese population: the Hisayama Study. 査読国際誌

Ninomiya T, Kojima I, Doi Y, Fukuhara M, Hirakawa Y, Hata J, Kitazono T, Kiyohara Y

J Hypertens 31 2013年3月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Risk score for predicting recurrence in patients with ischemic stroke: the fukuoka stroke risk score for Japanese. 査読国際誌

Kamouchi M, Kumagai N, Okada Y, Origasa H, Yamaguchi T, Kitazono T

Cerebrovasc Dis 34 2012年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Association between glucose tolerance level and cancer death in a general Japanese Population: the Hisayama Study. 査読国際誌

Hirakawa Y, Ninomiya T, Mukai N, Doi Y, Hata J, Fukuhara M, Iwase M, Kitazono T, Kiyohara Y

Am J Epidemiol 176 2012年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Insulin resistance and the development of cardiovascular disease in a Japanese community: the Hisayama Study. 査読国際誌

Gotoh S, Doi Y, Hata J, Ninomiya T, Mukai N, Fukuhara M, Kamouchi M, Kitazono T, Kiyohara Y

J Atheroscler Thromb 19 2012年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Lower levels of high-density lipoprotein cholesterol on admission and a recurrence of ischemic stroke: A 12-month follow-up of the Fukuoka Stroke Registry. 査読国際誌

Kuwashiro T, Sugimori H, Kamouchi M, Ago T, Kitazono T, Iida M

J Stroke Cerebrovasc Dis 21 2012年10月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Antegrade internal cartoidartery collateral flow and cerebral blood flow in patients with common cartoid artery occlusion. 査読国際誌

Nakamura A, Wakugawa Y, Yasaka M, Ogata T, Yasumori K, Kitazono T, Okada Y

J Ultrasound Med 31 2012年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Self-reported dietary intake of potassium, calcium, and magnesium and risk of dementia in the Japanese: the Hisayama Study. 査読国際誌

Ozawa M, Ninomiya T, Ohara T, Hirakawa Y, Doi Y, Hata J, Uchida K, Shirota T, Kitazono T, Kiyohara Y

JAGS 60 2012年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Optimal cutoff value of the serum pepsinogen level for prediction of gastric cancer incidence: the Hisayama Study. 査読国際誌

Shikata K, Ninomiya T, Yonemoto K, Ikeda F, Hata J, Doi Y, Fukuhara M, Matsumoto T, Iida M, Kitazono T, Kiyohara Y

Scand J Gastroenterol 47 2012年6月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Impact of lower range of prehypertension on cardiovascular events in a general population: the Hisayama Study. 査読国際誌

Fukuhara M, Arima H, Ninomiya T, Hata J, Yonemoto K, Doi Y, Hirakawa Y, Matsumura K, Kitazono T, Kiyohara Y.

J Hypertens 30 2012年5月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Neurotrophin production in brain pericytes during hypoxia: a role of pericytes for neuroprotection. 査読国際誌

Ishitsuka K, Ago T, Arimura K, Nakamura K, Tokami H, Makihara N, Kuroda J, Kamouchi M, Kitazono T.

Microvasc Res 83 ( 3 ) 2012年5月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
The factors associated with a functional outcome after ischemic stroke in diabetic patients: the Fukuoka Stroke Registry. 査読国際誌

Kuwashiro T, Kamouchi M, Ago T, Hata J, Sugimori H, Kitazono T.

J Neurol Sci 313 2012年2月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Risk factors predisposing to stroke recurrence within one year of non-cardioembolic stroke onset: The Fukuoka Stroke Registry. 査読国際誌

Kuwashiro T, Sugimori H, Ago T, Kamouchi M, Kitazono T, for the FSR Investigators.

Cerebrovasc Dis 33 2012年2月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Long-term results of medical and surgical therapy for Japanese patients with moderate carotid stenosis. 査読国際誌

Ogata T, Yasaka M, Wakugawa Y, Inoue T, Yasumori K, Kitazono T, Iida M, Okada Y.

J Stroke Cerebrovasc Dis 21 ( 1 ) 2012年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Differences in diffusion-weighted image and transesophageal echocardiographical findings in cardiogenic, paradoxical and aortogenic brain embolism. 査読国際誌

Fujimoto S, Toyoda K, Jinnouchi J, Yasaka M, Kitazono T, Okada Y.

Cerebrovasc Dis 32 ( 2 ) 2011年7月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Lower levels of high-density lipoprotein cholesterol on admission and a recurrence of ischemic stroke: a 12-month follow-up of the Fukuoka Stroke Registry. 査読国際誌

Kuwashiro T, Sugimori H, Kamouchi M, Ago T, Kitazono T, Iida M

J Stroke Cerebrovasc Dis 2011年3月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Combined effects of smoking and hypercholesterolemia on the risk of stroke and coronary heart disease in Japanese: the Hisayama Study. 査読国際誌

Hata J, Doi Y, Ninomiya T, Fukuhara M, Ikeda F, Mukai N, Hirakawa Y, Kitazono T, Kiyohara Y.

Cerebrovasc Dis 31 ( 5 ) 2011年3月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Outcomes associated with carotid pseudo-occlusion. 査読国際誌

Ogata T, Yasaka M, Kanazawa Y, Wakugawa Y, Inoue T, Yasumori K, Kitazono T, Okada Y.

Cerebrovasc Dis 31 ( 5 ) 2011年3月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Prognosis of medical treatment for Japanese patients with carotid stenosis. 査読国際誌

Ogata T, Yasaka M, Wakugawa Y, Yasumori K, Kitazono T, Okada Y.

Intern Med 50 ( 4 ) 2011年2月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Morphological classification of mobile plaques and their association with early recurrence of stroke. 査読国際誌

Ogata T, Yasak M, Wakugawa Y, Inoue T, Kitazono T, Okada Y.

Cerebrovasc Dis 30 ( 6 ) 2010年10月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population. 査読国際誌

Matsushita T, Umeno J, Hirakawa Y, Yonemoto K, Ashikawa K, Amitani H, Ninomiya T, Hata J, Doi Y, Kitaozono T, Iida M, Nakamura Y, Kiyohara Y, Kubo M.

J Hum Genet 55 ( 7 ) 2010年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）
The effect of metabolic syndrome defined by various criteria on the development of ischemic stroke subtypes in a general Japanese population. 査読国際誌

Hata J, Doi Y, Ninomiya T, Tanizaki Y, Yonemoto K, Fukuoara M, Kubo M, Kitazono T, Iida M, Kiyohara Y.

Atherosclerosis 210 ( 1 ) 2010年5月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Change in intracellular pH causes the toxic Ca2+ entry via NCX1 in neuron- and glia-derived cells. 査読国際誌

Shono Y, Kamouchi M, Kitazono, T, Kuroda J, Nakamura K, Hagiwara N, Ooboshi H, Ibayashi S, Iida M

Cell Mol Neurobiol 30 ( 3 ) 2010年4月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Midkine gene transfer protects against focal brain ischemia and augments neurogenesis. 査読国際誌

Ishikawa E, Ooboshi H, Kumai Y, Takada J, Nakamura K, Ago T, Sugimori H, Kamouchi M, Kitazono T, Ibayashi S, Iida M

J Neurol Sci 285 ( 1 ) 2009年10月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
The role of redox modulation of class II histone deacetylases in mediation pathological cardiac hypertrophy. 査読国際誌

Oka S, Ago T, Kitazono T, Zablocki D, Sadoshima J

J Mol Med 87 ( 8 ) 2009年8月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Flow volume and cross-sectional area of the extracranial vertebral arteries and its relation to vascular lesions or anatomical variation in the posterior circulation. 査読国際誌

Wakugawa Y, Sugimori H, Nakane H, Hata J, Irie K, Kitazono T, Iida M

Ultrasound Med Biol 35 ( 7 ) 2009年7月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Amiloride inhibits hydrogen peroxide-induced Ca2+ responses in human CNS pericytes. 査読国際誌

Nakamura K, Kamouchi M, Kitazono T, Kuroda J, Shono Y, Hagiwara N, Ago T, Ooboshi H, Ibayashi S, Iida M

Microvasc Res 77 ( 3 ) 2009年5月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Lack of association between variation of PDE4D and ischemic stroke in the Japanese population. 査読国際誌

Matsushita T, Kubo M, Yonemoto K, Ninomiya T, Ashikawa K, Liang B, Hata J, Doi Y, Kitazono T, Ibayashi S, Iida M, Kiyohara Y, Nakamura Y

Stroke 40 ( 4 ) 2009年4月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Cerebral venous thrombosis associated with iron deficiency anemia. 査読国際誌

Ogata T, Kamouchi M, Kitazono T, Kuroda J, Ooboshi H, Shono T, Morioka T, Ibayashi S, Sasaki T, Iida M.

J Stroke Cereb Dis 17 ( 6 ) 2008年11月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Polymorphism in the sorbin and SH3-domain- containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population: the Fukuoka Stroke Registry and the Hisayama Study 査読国際誌

Hagiwara N, Kitazono T, Kamouchi M, Kuroda J, Ago T, Hata J, Ninomiya T, Ooboshi H, Kumai Y, Yoshimura S, Tamaki K, Fujii K, Nagao T, Okada Y, Toyoda K, Nakane H, Sigimori H, Yamashita Y, Kubo M, Tanizaki Y, Kiyohara Y, Ibayashi S, Iida M

European Journal of Neurology 2008年5月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Protective effects of angiotensin II type 1 receptor blocker on cerebral circulation independent of blood pressure 査読国際誌

Kumai Y, Ooboshi H, Ago T, Ishikawa E, Takada J, Kamouchi M, Kitazono T, Ibayashi S, Iida M

Experimental Neurology 2008年4月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Polymorphisms in the lymphotoxin alpha gene and the risk of ischemic stroke in the Japanese population: the Fukuoka Stroke Registry and the Hisayama Study 査読国際誌

Hagiwara N, Kitazono T, Kamouchi M, Kuroda J, Ago T, Hata J, Ninbomiya T, Ooboshi H, Kumai Y, Yoshimura S, Tamaki K, Fujii K, Nagao T, Okada Y, Toyoda K, Nakane H, Sugimori H, Yamashita Y, Wakugawa Y, Kubo M, Tanizaki Y, Kiyohara Y, Ibayashi S, Iida M

Cerebrovascular Disease 2008年3月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Renal and carotid vascular resistance assessed with Doppler sonography. 査読国際誌

Ohta Y, Fujii K, Ibayashi S, Matsumura K, Tsuchihashi T, Kitazono T, Ooboshi H, Kamouchi M, Hirakata H, Ogata T, Kuroda J, Iida M.

J Clin Ultrasound 36 ( 2 ) 2008年2月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Postischemic gene transfer of soluble Flt-1 protects against brain ischemia with marked attenuation of blood-brain barrier permeability. 査読国際誌

Kumai Y, Ooboshi H, Ibayashi S, Ishikawa E, Sugimori H, Kamouchu M, Kitazono T, Egashira K, Iida, M.

J Cereb Blood Flow Metab 27 ( 6 ) 2007年6月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Hydrogen peroxide-induced Ca2+ responses in CNS pericytes. 査読国際誌

Kamouchi M, Kitazono T, Ago T, Wakisaka M, Kuroda J, Nakamura K, Hagiwara N, Ooboshi H, Ibayashi S, Iida, M.

Neurosci Lett 416 ( 1 ) 2007年4月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction. 査読国際誌

Hata J, Matsuda K, Ninomiya T, Yonemoto K, Matsushita T, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Iida M, Kiyohara Y, Nakamura Y, Kubo M.

Hum Mol Genet 16 ( 6 ) 2007年3月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Role of substantia innominata in cerebral blood flow autoregulation 査読国際誌

Ota K, Kitazono T, Ooboshi H, Kamouchi M, Katafuchi M, Aou S, Yamashita Y, Ibayashi S, Iida M

Brain Research 2007年3月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Blood pressure changes during the initial week after different subtypes of ischemic stroke. 査読国際誌

Toyoda K, Okada Y, Fujimoto S, Hagiwara N, Nakachi K, Kitazono T, Ibayashi S, Iida M.

Stroke 37 ( 10 ) 2006年10月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Valsartan improves the lower limit of cerebral autoregulation in rats. 査読国際誌

Takada J, Ibayashi S, Ooboshi H, Ago T, Ishikawa E, Kamouchi M, Kitazono T, Iida M.

Hypertens Res 29 ( 8 ) 2006年8月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Blood pressure control in hypertensive patients with a history of stroke. 査読国際誌

Ohta Y, Tsuchihashi T, Ibayashi S, Matsumura K, Kitazono T, Ooboshi H, Kamouchi M, Fujii K, Iida M.

J Stroke Cerebrovasc Dis 14 ( 6 ) 2005年11月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Selective induction of ΔFosB in the brain after transient forebrain ischemia accompanied by an increased expression of galectin-1, and the implication ofΔFosB and galectin-1 in neuroprotection and neurogenesis. 査読国際誌

12 ( 8 ) 1078 - 1096 2005年8月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1038/sj.cdd.4401648
The yeast eIF4E-associated protein Eap1p attenuates GCN4 translation upon TOR-inactivation. 査読国際誌

Matsuo R, Kubota H, Obata T, Kito K, Ota K, Kitazono T, Ibayashi S, Sasaki T, Iida M, Ito T.

FEBS Lett 579 ( 11 ) 2433 - 2438 2005年4月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/j.febslet.2004.03.043
Postischemic gene transfer of midkine, a neurotrophic factor, protects against focal brain ischemia. 査読国際誌

Takada J, Ooboshi H, Ago T, Kitazono T, Yao H, Kadomatsu K, Muramatsu T, Ibayashi S, Iida M.

Gene Ther 12 ( 6 ) 487 - 493 2005年3月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1038/sj.gt.3302434
Postoschemic gene transfer of interleukin-10 protects against both focal and global brain ischemia. 査読国際誌

Ooboshi H, Ibayashi S, Shichita T, Kumai Y, Takada J, Ago T, Arakawa S, Sugimori H, Kamouchi M, Kitazono T, Iida M.

Circulation 111 ( 7 ) 2005年2月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Anti-monocyte chemoattractant protein-1 gene therapy protects against focal brain ischemia in hypertensive rats. 査読国際誌

Kumai Y, Ooboshi H, Takada J, Kamouchi M, Kitazono T, Egashira K, Ibayashi S, Iida M.

J Cereb Blood Flow Metab 24 ( 12 ) 1359 - 1368 2004年12月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1097/01.WCB.00001473534
Relationship between plasma glutathione levels and cardiovascular disease in a defined population: The Hisayama Study. 査読国際誌

Shimizu H, Kiyohara Y, Kato I, Kitazono T, Tanizaki Y, Kubo M, Ueno H, Ibayashi S, Fujishima M, Iida M.

Stroke 35 ( 9 ) 2072 - 2077 2004年9月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1161/01.STR.0000138022.86509.2d
Calcium influx pathways in rat CNS pericytes. 査読国際誌

Kamouchi M, Kitazono T, Ago T, Wakisaka M, Ooboshi H, Ibayashi S, Iida M.

Mol Brain Res 126 ( 2 ) 114 - 120 2004年7月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/j.molbrainres.2004.03.008
PPARgamma ligands attenuate mesangial contractile dysfunction in high glucose. 査読国際誌

Ueta, M., Wakisaka, M., Ago, T., Kitazono, T., Nakamura, U., Yoshinari, M., Iwase, M., Iida, M.

Kideny International 65 ( 3 ) 961 - 971 2004年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1111/j.1523-1755.2004.00474.x
Photothrombotic middle cerebral artery occlusion and reperfusion laser system in spontaneously hypertensive rats. 査読国際誌

Yao H, Sugimori H, Fukuda K, Takada J, Ooboshi H, Kitazono T, Ibayashi S, Iida M.

Stroke 34 ( 11 ) 2716 - 2721 2003年11月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1161/01.STR.0000094730.38343.73
Adenovirus-mediated gene transfer to ischemic brain is augmented in aged rats. 査読国際誌

Takada J, Ooboshi H, Yao H, Kitazono T, Ibayashi S, Iida M.

Exp Gerontol 38 ( 4 ) 423 - 429 2003年4月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/S0531-5565(02)00241-3
Brain ischemia augments exo-focal transgene expression of adenovirus-mediated gene transfer to ependyma in hypertensive rats. 査読国際誌

Kumai, Y., Ooboshi, H., Kitazono, T., Takada, J., Ibayashi, S., Fujishima, M., Iida, M.

Experimental Neurology 184 ( 2 ) 904 - 911 2003年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/j.expneurol.2003.08.022
ATP-sensitive potassium channels mediate dilatation of the basilar artery in response to intracellular acidification in vivo. 査読国際誌

Santa, N., Kitazono, T., Ago, T., Ooboshi, H., Kamouchi, M., Wakisaka, M., Ibayashi, S., Iida, M.

Stroke 34 ( 5 ) 1276 - 1280 2003年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1161/01.STR.0000068171.01248.97
Role of Ca2+-activated K+ channels in the regulation of basilar arterial tone in spontaneously hypertensive rats. 査読国際誌

Kamouchi M, Kitazono T, Nagao T, Fujishima M, Ibayashi S.

Clin Exp Pharmacol Physiol 29 ( 7 ) 575 - 581 2002年7月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1046/j.1440-1681.2002.03688.x
Long-term effects of benidipine on cerebral vasoreactivity in hypertensive rats. 査読国際誌

Kitayama J, Kitazono T, Ooboshi H, Takada J, Fujishima M, Ibayashi S.

Eur J Pharmacol 438 ( 3 ) 153 - 158 2002年3月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/S0014-2999(02)01311-0
Chronic adminisitration of a tyrosine kinase inhibitor restores functional and morphological changes of the basilar artery during chronic hypertension. 査読国際誌

Kitayama, J., Kitazono, T., Ooboshi, H., Ago, T., Ohgami, T., Fujishima, M., Ibayashi, S.

Journal of Hypertension 2002年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Role of Na+/H+ exchanger in dilator responses of rat basilar artery in vivo. 査読国際誌

Kitazono T, Kamouchi M, Ago T, Ooboshi H, Nakamura H, Fujishima M, Ibayashi S.

Brain Res 906 ( 1-2 ) 2001年7月

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記述言語：英語掲載種別：研究論文（学術雑誌）
Bradykinin mediates the acute effect of an angiotensin-converting enzyme inhibitor on cerebral autoregulation in rats. 査読国際誌

Takada J, Ibayashi S, Nagao T, Ooboshi H, Kitazono T, Fujishima M.

Stroke 32 ( 5 ) 1216 - 1219 2001年5月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Adenovirus-mediated gene transfer to ischemic brain; ischemic flow threshold for transgene expression. 査読国際誌

Ooboshi H, Ibayashi S, Takada J, Yao H, Kitazono T, Fujishima M.

Stroke 32 ( 4 ) 1043 - 1047 2001年4月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Inhibition of Na+/H+ exchanger reduces infarct volume in thrombotic middle cerebral artery occlusion in rats. 査読国際誌

Kitayama, J., Kitazono, T., Yao, H., Ooboshi, H., Takaba, H., Ago, T., Fujishima, M., Ibayashi, S.

Brain Research 922 ( 2 ) 223 - 228 2001年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/S0006-8993(01)03175-4
Effect of diet on changes in small intestinal blood flow following intracolonic administration of indomethacin to rats. 査読国際誌

Yamamoto C, Kawakubo K, Aoyagi K, Matsumoto T, Iida M, Ibayashi S, Kitazono T, Doi K, Kanamoto K, Fujishima M.

Digest Dis Sci 46 ( 1 ) 200 - 207 2001年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1023/A:1005529016641
Calcium antagonist isradipine reduces metabolic alterations in acute cerebral ischemia in spontaneously hypertensive rats. 査読国際誌

Ibayashi S, Nagao T, Kitazono T, Ooboshi H, Kitayama J, Sadoshima S, Fujishima M.

Neurochem Res 25 ( 3 ) 349 - 355 2000年3月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1023/A:1007536919827
Effect of selective brain hypothermia on regional cerebral blood flow and tissue metabolism using brain thermoregulator in spontaneously hypertensive rats. 査読国際誌

Ibayashi S, Takano K, Ooboshi H, Kitazono T, Sadoshima S, Fujishima M.

Neurochem Res 25 ( 3 ) 369 - 375 2000年3月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1023/A:1007593004806
Cerebral blood flow and metabolism in patients with silent brain infarcton: occult misery perfusion in the cerebral cortex. 査読国際誌

Nakane H, Ibayashi S, Fujii K, Sadoshima S, Irie K, Kitazono T, Fujishima M.

J Neurol Neurosurg Psychiatr 65 ( 3 ) 317 - 321 1998年9月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1136/jnnp.65.3.317
Attenuation and recovery of brain stem autoregulation in spontaneously hypertensive rats. 査読国際誌

Toyoda K, Fujii K, Ibayashi S, Kitazono T, Nagao T, Takaba H, Fujishima M.

J Cereb Blood Flow Metab 18 ( 3 ) 305 - 310 1998年3月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Role of tyrosine kinase in serotonin-induced constriction of rat basilar artery in vivo. 査読国際誌

Kitazono, T., Ibayashi, S., Nagao, T., Kagiyama, T., Kitayama, J., Fujishima, M.

Stroke 29 ( 2 ) 494 - 497 1998年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Protein kinase C modulates ischemia-induced amino acids release in the striatum of hypertensive rats. 査読国際誌

Nakane H, Yao H, Ibayashi S, Kitazono T, Ooboshi H, Uchimura H, Fujishima M.

Brain Res 782 ( 1-2 ) 290 - 296 1998年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/S0006-8993(97)01331-0
Effects of long-acting angiotensin-converting enzyme inhibitor, imidapril, on the lower limit of cerebral blood flow autoregulation in hypertensive rats. 査読国際誌

Cai H, Yao H, Ibayashi S, Zhao G, Kitazono T, Nagao T, Fujishima M.

Eur J Pharmacol 341 ( 1 ) 73 - 77 1998年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/S0014-2999(97)01459-3
Role of nitric oxide in regulation of brain stem circulation during hypotension. 査読国際誌

Toyoda K, Fujii K, Ibayashi S, Nagao T, Kitazono T, Fujishima M.

J Cereb Blood Flow Metab 17 ( 10 ) 1089 - 1096 1997年10月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Role of ATP-sensitive potassium channels in brain stem circulation during hypotension. 査読国際誌

Toyoda K, Fujii K, Ibayashi S, Kitazono T, Nagao T, Fujishima M.

Am J Physiol 273 ( 3 ) H1342 - H1346 1997年9月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
An ATP-sensitive potassium channel activator reduces infarct volume in focal cerebral ischemia in rats. 査読国際誌

Takaba H, Nagao T, Yao H, Kitazono T, Ibayashi S, Fujishima M.

Am J Physiol 273 ( 2 ) R583 - R586 1997年8月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Role of Ca2+-activated K+ channels in acetylcholine-induced dilatation of the basilar artery in vivo. 査読国際誌

Kitazono, T., Ibayashi, S., Nagao, T., Fujii, K., Fujishima, M.

Britich Journal of Pharmacology 120 ( 1 ) 102 - 106 1997年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1038/sj.bjp.0700880
Age-related changes in response of brain stem vessels to opening of ATP-sensitive potassium channels. 査読国際誌

Toyoda K, Fujii K, Takata Y, Ibayashi S, Kitazono T, Nagao T, Fujikawa M, Fujishima M.

Stroke 28 ( 1 ) 171 - 175 1997年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Altered cerebrovascular response to a potassium channel opener in hypertensive rats. 査読国際誌

Takaba H, Nagao T, Ibayashi S, Kitazono T, Fujii K, Fujishima M.

Hypertension 28 ( 1 ) 143 - 146 1996年7月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
L-Arginine restores dilator responses of the basilar artery to acetylcholine during chronic hypertension. 査読国際誌

Kitazono, T., Faraci, F.M., Heistad, D.D.

Hypertension 1996年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Relaxation of the carotid artery to hypoxia is impaired in Watanabe heritable hyperlipidemic rabbits. 査読国際誌

Taguchi, H., Faraci, F.M., Kitazono, T., Heistad, D.D.

Arteriosclerosis Thrombosis and Vascular Biology 1995年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Dilatation of the basilar artery in response to selective activation of endothelin B receptors in vivo. 査読国際誌

Kitazono, T., Heistad, D.D., Faraci, F.M.

Journal of Pharmacology and Experimental Therapeutics 1995年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Activation of cultured bovine aortic endothelial cells by extracellular pyrimidine triphosphate. 査読国際誌

Kitazono T, Takeshige K, Minakami S.

Int J Biochem 24 ( 8 ) 1323 - 1327 1992年8月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Influence of haemorrhagic transformation on the outcome of thrombolytic therapy for patients with acute brain embolism. 査読国際誌

Okada Y, Sadoshima S, Saku Y, Kitazono T, Irie K, Ogasawara T, Utsunomiya H, Fujishima M.

Neurol Res 14 ( 2 ) 1992年2月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）
Involvement of calcium and protein kinase C in the activation of the Na+/H+ exchanger in cultured bovine aortic endotehlial cells stimulated by extracellular ATP. 査読国際誌

Kitazono, T., Takeshige, K., Cragoe, E.J., Jr., Minakami, S.

Biochimica et Biophysica Acta 1013 ( 2 ) 152 - 158 1989年1月

　詳細を見る

記述言語：英語掲載種別：研究論文（学術雑誌）

DOI： 10.1016/0167-4889(89)90043-8

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担当ページ：pp65-66 記述言語：日本語著書種別：一般書・啓蒙書
高血圧診療ステップアップ－高血圧治療ガイドラインを極める－　高血圧性合併症の特徴と治療　脳血管障害.

脇坂義信，北園孝成（担当：共著）

診断と治療社 2019年5月

　詳細を見る

担当ページ：pp138-146 記述言語：日本語著書種別：学術書
症例から学ぶ戦略的急性期脳卒中診断・治療　症例　脳梗塞　Branch atheromatous diseaseにより麻痺症状の動揺を呈した症例.

山中圭, 脇坂義信, 北園孝成（担当：共著）

南山堂 2019年3月

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担当ページ：pp96-104 記述言語：日本語著書種別：一般書・啓蒙書
症例から学ぶ戦略的急性期脳卒中診断・治療　症例　脳梗塞　緩徐に進行するラクナ梗塞を発症した症例.

高島正光, 脇坂義信, 北園孝成（担当：共著）

南山堂 2019年3月

　詳細を見る

記述言語：日本語著書種別：学術書
脳卒中エキスパート　抗血栓療法を究める　無症候性脳梗塞,無症候性頸部・頭蓋内脳動脈狭窄・閉塞.

森興太, 脇坂義信, 北園孝成（担当：共著）

中外医学社 2019年1月

　詳細を見る

担当ページ：pp63-78 記述言語：日本語著書種別：学術書
糖尿病と循環器病一歩進んだ糖尿病循環器学．糖尿病合併循環器病の病態と治療（4）脳卒中．

松尾　龍, 北園孝成（担当：共著）

医薬ジャーナル社 2017年3月

　詳細を見る

担当ページ：pp152-158 記述言語：日本語著書種別：学術書
虚血性中枢神経障害の基礎と臨床．虚血性脳卒中の予防と積極的内科治療．

脇坂義信, 北園孝成（担当：共著）

真興交易 2016年5月

　詳細を見る

担当ページ：pp80-101 記述言語：日本語著書種別：学術書
レジデントのための脳卒中診療のコツ．慢性期再発予防のコツ．

中村晋之, 北園孝成（担当：共著）

文光堂 2014年1月

　詳細を見る

担当ページ：pp90-98 記述言語：日本語著書種別：学術書
脳卒中診療こんなときどうするQ＆A 第2版．脳卒中予防のための高血圧管理：至適血圧や降圧薬の種類を含む最近の考え方について教えてください．

牧原典子, 井林雪郎, 北園孝成（担当：共著）

中外医学社 2012年3月

　詳細を見る

担当ページ：pp260-263 記述言語：日本語著書種別：学術書
ファーマナビゲーター：脳卒中編．脳卒中急性期治療の実際：急性期の降圧治療．

北園孝成（担当：共著）

メディカルビュー社 2006年4月

　詳細を見る

担当ページ：pp276-281 記述言語：日本語著書種別：学術書
心血管系疾患とレニン・アンジオテンシン系－新世代アンジオテンシンⅡ受容体拮抗薬による検証－．アンジオテンシンⅡ受容体拮抗薬の脳循環への影響．

北園孝成，藤島正敏（担当：共著）

先端医学社 2000年9月

　詳細を見る

担当ページ：pp166-172 記述言語：日本語著書種別：学術書
AⅡ受容体拮抗薬のすべて(第2版)．脳血管障害を伴った高血圧とAⅡ受容体拮抗薬．

北園孝成，藤島正敏（担当：共著）

先端医学社 2000年1月

　詳細を見る

担当ページ：pp202-208 記述言語：日本語著書種別：学術書
メガトライアルから学ぶ循環器疾患の治療，EvidenceからPracticeへ．降圧薬治療と脳血管障害（一次予防）－脳卒中予防のための降圧薬治療－MRC, STONEの検討より．

北園孝成，井林雪郎（担当：共著）

先端医学社 1999年10月

　詳細を見る

担当ページ：pp287-292 記述言語：日本語著書種別：学術書
代謝面からみた高血圧と標的臓器障害の予防と管理．α遮断薬の脳循環への影響．

北園孝成，藤島正敏（担当：共著）

先端医学社 1999年8月

　詳細を見る

担当ページ：pp204-211 記述言語：日本語著書種別：学術書
循環器疾患とＮＯ．脳循環とＮＯ．

北園孝成（担当：共著）

南山堂 1998年1月

　詳細を見る

担当ページ：pp141-149 記述言語：日本語著書種別：学術書
降圧薬－上手な使用法と健康管理．脳卒中急性期・慢性期合併例．

北園孝成，佐渡島省三（担当：共著）

メディカルコア 1997年5月

　詳細を見る

担当ページ：pp169-176 記述言語：日本語著書種別：学術書

▼全件表示

講演・口頭発表等

脳卒中発症後の降圧治療の現状と課題．招待

北園孝成、鴨打正浩

第34回日本高血圧学会総会 2011年10月

　詳細を見る

開催年月日： 2011年10月

会議種別：シンポジウム・ワークショップパネル（公募）

開催地：宇都宮市国名：日本国
Fukuoka Stroke Registryにみる日本人の脳卒中．招待

北園孝成、鴨打正浩

第36回日本脳卒中学会総会 2011年8月

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開催年月日： 2011年7月 - 2011年8月

会議種別：シンポジウム・ワークショップパネル（公募）

開催地：京都市国名：日本国
エアロゾルの脳卒中発症に及ぼす影響に関する研究－Fukuoka Stroke Registry (FSR)．招待

北園孝成、杉森　宏、新田裕史、吾郷哲朗、桑城貴弘、鴨打正浩

第36回日本脳卒中学会総会 2011年7月

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開催年月日： 2011年7月 - 2011年8月

会議種別：口頭発表（招待・特別）

開催地：京都市国名：日本国
脳梗塞のバイオマーカー探索研究（REBIOS）. 招待

北園孝成、鴨打正浩、吾郷哲朗、粟野秀人、鈴木一夫、清原　裕.

第33回日本分子生物学会年会/第83回日本生化学会大会合同大会 2010年12月

　詳細を見る

開催年月日： 2010年12月

会議種別：シンポジウム・ワークショップパネル（公募）

開催地：神戸市国名：日本国
多施設共同脳卒中データベース（Fukuoka Stroke Registry）から見えてきた脳梗塞急性期の病態と予後.

北園孝成、鴨打正浩、中根　博、尾前　豪、杉森　宏、吾郷哲朗、桑城貴弘、飯田三雄、佐渡島省三.

第35回日本脳卒中学会総会 2010年4月

　詳細を見る

開催年月日： 2010年4月

会議種別：シンポジウム・ワークショップパネル（公募）

開催地：盛岡国名：日本国
多施設共同脳卒中データベース（Fukuoka Stroke Registry; FSR）からみた脳梗塞急性期症例の高血圧ならびに慢性腎臓病（CKD）の実態招待

北園孝成、熊井康敬、杉森　宏、中根　博、鴨打正浩、大星博明、井林雪郎、飯田三雄、佐渡島省三

第34回日本脳卒中学会総会 2009年3月

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開催年月日： 2009年3月

会議種別：シンポジウム・ワークショップパネル（公募）

国名：日本国
脳血管障害の分子疫学：久山町研究と福岡脳卒中データベース研究（ＦＳＲ）招待

北園孝成、久保充明、秦　淳、清原　裕、井林雪郎、飯田三雄

第49回日本神経学会総会 2008年5月

　詳細を見る

開催年月日： 2008年5月

会議種別：シンポジウム・ワークショップパネル（公募）

開催地：横浜国名：日本国
脳卒中の病態と治療

北園孝成

第36回日本臨牀内科医学会 2023年10月

　詳細を見る

開催年月日： 2023年10月

記述言語：日本語会議種別：口頭発表（一般）

開催地：ホテル日航福岡国名：日本国
循環器病対策推進基本計画と脳卒中医療

北園孝成

第31回日本心血管インターベンション治療学会学術集会 2023年8月

　詳細を見る

開催年月日： 2023年8月

記述言語：日本語会議種別：口頭発表（一般）

開催地：ヒルトン福岡シーホーク国名：日本国
PRASTRO試験

北園孝成

第39回日本神経治療学会学術集会 2021年10月

　詳細を見る

開催年月日： 2022年6月

記述言語：日本語会議種別：シンポジウム・ワークショップパネル（公募）

国名：日本国
脳卒中の病態と最新治療招待

北園孝成

第118回日本内科学会総会・講演会 2021年4月

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開催年月日： 2022年6月

記述言語：日本語会議種別：口頭発表（一般）

国名：日本国

リポジトリ公開URL： https://hdl.handle.net/2324/7172583
高齢者脳卒中の特徴と予後

北園孝成、松尾　龍

第62回日本老年医学会学術集会 2020年8月

　詳細を見る

開催年月日： 2021年5月

記述言語：日本語会議種別：シンポジウム・ワークショップパネル（公募）

国名：日本国
脳梗塞の病態解明：基礎研究と臨床研究の融合を目指して

北園孝成

第46回日本脳卒中学会学術集会 2021年3月

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開催年月日： 2021年3月

記述言語：日本語会議種別：口頭発表（一般）

国名：日本国
脳梗塞再発リスク因子を有する血栓性脳梗塞患者を対象としたプラスグレル第3相試験：PRASTRO-Ⅲ

北園孝成、鴨打正浩、松丸祐司、中村正人、梅村和夫、松尾　創、小山暢之、堤　順子、木村和美

第46回日本脳卒中学会学術集会 2021年3月

　詳細を見る

開催年月日： 2021年3月

記述言語：日本語

国名：日本国
脳卒中と認知症の危険因子とその管理

北園孝成、二宮利治

第45回日本脳卒中学会学術集会 2020年8月

　詳細を見る

開催年月日： 2020年8月

記述言語：日本語会議種別：シンポジウム・ワークショップパネル（公募）

国名：日本国
高血圧ガイドライン2019（JSH2019）

北園孝成

第45回日本脳卒中学会学術集会 2020年8月

　詳細を見る

開催年月日： 2020年8月

記述言語：日本語会議種別：シンポジウム・ワークショップパネル（公募）

国名：日本国
コホート研究から学ぶ脳卒中の予防と管理

北園孝成

第３４回日本女性医学会学術集会 2019年11月

　詳細を見る

開催年月日： 2020年7月

記述言語：日本語会議種別：口頭発表（一般）

国名：日本国
脳卒中にならないための健康管理

北園孝成

平成３０年度第７回都民講座 2019年1月

　詳細を見る

開催年月日： 2020年7月

記述言語：日本語

国名：日本国
コホート研究からみた脳梗塞の病態と治療

北園孝成

第１回福岡県内科医会・福岡県臨床外科医学会合同講演会 2019年2月

　詳細を見る

開催年月日： 2020年7月

記述言語：日本語会議種別：口頭発表（一般）

国名：日本国
脳梗塞病型ごとのP2Y12阻害薬の有効性と安全性：PTASTRO-1サブ解析

北園孝成、豊田一則、北川一夫、長尾毅彦、山上宏　小川彰

第４４回日本脳卒中学会学術集会 2019年3月

　詳細を見る

開催年月日： 2020年7月

記述言語：日本語会議種別：シンポジウム・ワークショップパネル（公募）

国名：日本国
脳血管障害患者における降圧目標

北園孝成

第８回臨床高血圧フォーラム 2019年5月

　詳細を見る

開催年月日： 2020年7月

記述言語：日本語会議種別：シンポジウム・ワークショップパネル（公募）

国名：日本国
脳梗塞の病態と治療

北園孝成

第１９回日本NO学会学術集会 2019年6月

　詳細を見る

開催年月日： 2020年7月

記述言語：日本語会議種別：口頭発表（招待・特別）

国名：日本国
脳卒中コホート研究からみた心房細動合併脳梗塞患者の実態

北園孝成

第６回日本心血管脳卒中学会学術集会 2019年6月

　詳細を見る

開催年月日： 2020年7月

記述言語：日本語会議種別：シンポジウム・ワークショップパネル（公募）

国名：日本国
脳梗塞病型ごとのP2Y12阻害薬の有効性と安全性：PRASTRO-Iサブ解析

北園孝成

第44回日本脳卒中学会学術集 2019年3月

　詳細を見る

開催年月日： 2019年6月

記述言語：日本語会議種別：口頭発表（一般）

国名：日本国
脳梗塞の病態とリスク管理

北園孝成

2018年6月

　詳細を見る

開催年月日： 2019年6月

記述言語：日本語会議種別：口頭発表（一般）

国名：日本国
超高齢社会における心原性脳塞栓症の治療戦略

北園孝成

北多摩脳卒中フォーラム 2018年8月

　詳細を見る

開催年月日： 2019年6月

記述言語：日本語会議種別：口頭発表（一般）

国名：日本国
心原性脳塞栓症の病態と治療

北園孝成

鳥栖・三養基医師会講演会 2018年8月

　詳細を見る

開催年月日： 2019年6月

記述言語：日本語会議種別：口頭発表（一般）

国名：日本国
臨床疫学研究からみた脳梗塞の病態と治療

北園孝成