Updated on 2024/07/28

Information

 

写真a

 
OGAWA YOSHIHIRO
 
Organization
Faculty of Medical Sciences Department of Clinical Medicine Professor
Kyushu University Hospital Department of Endocrine and Metabolic Diseases / Diabetes Mellitus(Joint Appointment)
Kyushu University Hospital Department of Hepatology and Pancreatology(Joint Appointment)
Faculty of Medical Sciences Research Institute for Deseases of the Chest(Joint Appointment)
School of Medicine Department of Medicine(Joint Appointment)
Graduate School of Medical Sciences Department of Medicine(Joint Appointment)
Graduate School of Medical Sciences Department of Medical Sciences(Joint Appointment)
Title
Professor
Profile
内分泌代謝・糖尿病内科学と肝臓・膵臓・胆道内科学を中心に総合内科学の臨床・研究・教育に従事している。複数の研究機関において基礎講座・臨床講座を担当した経験を活かして、基礎と臨床の双方向性の研究・診療・教育活動を心掛けている。
Homepage

Degree

  • MD, PhD

Research History

  • 1997年4月~2003年3月 京都大学医学部附属病院内分泌・代謝内科 助手 2003年4月~2012年3月 東京医科歯科大学難治疾患研究所分子代謝医学分野 教授 2011年12月~2017年3月 東京医科歯科大学大学院医歯学総合研究科分子内分泌代謝学分野 教授 2016年4月~現在 名古屋大学環境医学研究所 客員教授 2017年4月~2019年3月 東京医科歯科大学大学院医歯学総合研究科分子細胞代謝学分野 教授

Research Interests・Research Keywords

  • Research theme:Diagnostic and therapeutic targets of pancreatic cancer using patient-derived pancreatic organoids

    Keyword:organoid

    Research period: 2021.4

  • Research theme:Pathogenesis and diagnostic and therapeutic strategies for endocrine diseases

    Keyword:Endocrine diseases, adrenal, pituitary

    Research period: 2016.9

  • Research theme:Molecular mechanisms of chronic inflammation and their clinical implications

    Keyword:Chronic inflammation, tissue fibrosis, macrophages, epigenetic memory, DNA methylation, DOHaD

    Research period: 2003.4

  • Research theme:Epigenetic regulation of lifestyle-related diseases and its clinical implications

    Keyword:Epigenetic memory, DNA methylation, DOHaD hypothesis

    Research period: 2003.4

Awards

  • 第27回(2023年度)高峰譲吉賞

    2023.11   日本心血管内分泌代謝学会   内分泌代謝学からみた生活習慣病の発症機構に関する研究

  • 令和5(2022)年 日本糖尿病・肥満動物学会学会賞「米田賞」

    2023.2   日本糖尿病・肥満動物学会   遺伝子操作マウスを用いた肥満関連疾患の分子病態に関する研究

  • 2019年度(令和元年)日本肥満学会学会賞

    2021.3   日本肥満学会   肥満研究:生涯チャレンジャーの軌跡

  • 第4回(2019年度)松尾賞

    2019.7   認定NPO法人日本ホルモンステーション   イムノメタボリズムからみた生活習慣病の分子機構の解明と医学応用

  • 平成31年度 科学技術分野の文部科学大臣表彰 科学技術賞

    2019.4   文部科学省   肥満に関連する生活習慣病の発症機構に関する研究

  • 第16回 杉田玄白賞

    2017.12   小浜市   生活習慣病の分子機構の解明と新しい治療戦略の開発

  • 第4回 日本糖尿病・肥満動物学会研究賞

    2011.3   日本糖尿病・肥満動物学会   糖尿病・肥満における慢性炎症の分子機構に関する研究

  • 第8回 日本臨床分子医学会学会賞

    2005.4   日本臨床分子医学会  

  • 第1回 井村臨床研究奨励賞

    2004.12   成人血管病研究振興財団   肥満遺伝子産物レプチンの臨床的意義に関する研究

  • 第7回  高峰譲吉研究奨励賞

    2003.12   日本心血管内分泌代謝学会  

  • 平成14年度 日本医師会医学研究奨励賞(医学研究助成費)

    2002.11   日本医師会  

  • 第18回 日本内分泌学会研究奨励賞

    1999.4   日本内分泌学会  

  • 第4回 日本肥満学会賞(日本肥満学会学術奨励賞)

    1998.10   日本肥満学会  

  • 第13回 岡本研究奨励賞

    1997.12   成人血管病研究振興財団  

  • 第13回 井上研究奨励賞

    1996.12   井上科学振興財団  

  • 第10回 日本内科学会奨励賞

    1996.4   日本内科学会  

  • 第11回 岡本研究奨励賞

    1995.12   成人血管病研究振興財団  

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Papers

  • Steroids-producing nodules: a two-layered adrenocortical nodular structure as a precursor lesion of cortisol-producing adenoma. International journal

    Tazuru Fukumoto, Hironobu Umakoshi, Norifusa Iwahashi, Tatsuki Ogasawara, Maki Yokomoto-Umakoshi, Hiroki Kaneko, Masamichi Fujita, Naohiro Uchida, Hiroshi Nakao, Namiko Kawamura, Yayoi Matsuda, Ryuichi Sakamoto, Takashi Miyazawa, Masahide Seki, Masatoshi Eto, Yoshinao Oda, Yutaka Suzuki, Seishi Ogawa, Yoshihiro Ogawa

    EBioMedicine   105087 - 105087   2024.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ebiom.2024.105087

  • Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH. International journal

    Michiko Itoh, Atsushi Tamura, Sayaka Kanai, Miyako Tanaka, Yohei Kanamori, Ibuki Shirakawa, Ayaka Ito, Yasuyoshi Oka, Isao Hidaka, Taro Takami, Yasushi Honda, Mitsuyo Maeda, Yasuyuki Saito, Yoji Murata, Takashi Matozaki, Atsushi Nakajima, Yosky Kataoka, Tomoo Ogi, Yoshihiro Ogawa, Takayoshi Suganami

    The Journal of experimental medicine   220 ( 11 )   2023.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1084/jem.20220681

  • Adrenal steroid metabolites and bone status in patients with adrenal incidentalomas and hypercortisolism

    Hiroshi Nakao, Maki Yokomoto-Umakoshi, Kohta Nakatani, Hironobu Umakoshi, Masatoshi Ogata, Tazuru Fukumoto, Hiroki Kaneko, Norifusa Iwahashi, Masamichi Fujita, Tatsuki Ogasawara, Yayoi Matsuda, Ryuichi Sakamoto, Yoshihiro Izumi, Takeshi Bamba, Yoshihiro Ogawa

    eBioMedicine   104733 - 104733   2023.8

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ebiom.2023.104733

  • Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis via the immunomodulating receptor GPR84. International journal

    Ryuji Ohue-Kitano, Hazuki Nonaka, Akari Nishida, Yuki Masujima, Daisuke Takahashi, Takako Ikeda, Akiharu Uwamizu, Miyako Tanaka, Motoyuki Kohjima, Miki Igarashi, Hironori Katoh, Tomohiro Tanaka, Asuka Inoue, Takayoshi Suganami, Koji Hase, Yoshihiro Ogawa, Junken Aoki, Ikuo Kimura

    JCI insight   8 ( 2 )   2023.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1172/jci.insight.165469

  • Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b. International journal

    Kensuke Shibata, Chihiro Motozono, Masamichi Nagae, Takashi Shimizu, Eri Ishikawa, Daisuke Motooka, Daisuke Okuzaki, Yoshihiro Izumi, Masatomo Takahashi, Nao Fujimori, James B Wing, Takahide Hayano, Yoshiyuki Asai, Takeshi Bamba, Yoshihiro Ogawa, Makoto Furutani-Seiki, Mutsunori Shirai, Sho Yamasaki

    Nature communications   13 ( 1 )   6948 - 6948   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-022-34802-8

  • Safety and efficacy of tirzepatide as an add-on to single oral antihyperglycaemic medication in patients with type 2 diabetes in Japan (SURPASS J-combo): a multicentre, randomised, open-label, parallel-group, phase 3 trial. International journal

    Takashi Kadowaki, Rina Chin, Akichika Ozeki, Takeshi Imaoka, Yoshihiro Ogawa

    The lancet. Diabetes & endocrinology   10 ( 9 )   634 - 644   2022.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S2213-8587(22)00187-5

  • Characterization of Aldosterone-producing Cell Cluster (APCC) at Single-cell Resolution. International journal

    Norifusa Iwahashi, Hironobu Umakoshi, Tsugio Seki, Celso E Gomez-Sanchez, Kuniaki Mukai, Makoto Suematsu, Yuta Umezawa, Mototsugu Oya, Takeo Kosaka, Masahide Seki, Yutaka Suzuki, Yutaka Horiuchi, Yoshihiro Ogawa, Koshiro Nishimoto

    The Journal of clinical endocrinology and metabolism   107 ( 9 )   2439 - 2448   2022.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/clinem/dgac394

  • Identification of a drug-response gene in multiple myeloma through longitudinal single-cell transcriptome sequencing. International journal

    Toru Masuda, Shojiro Haji, Yasuhiro Nakashima, Mariko Tsuda, Daisaku Kimura, Akiko Takamatsu, Norifusa Iwahashi, Hironobu Umakoshi, Motoaki Shiratsuchi, Chie Kikutake, Mikita Suyama, Yasuyuki Ohkawa, Yoshihiro Ogawa

    iScience   25 ( 8 )   104781 - 104781   2022.8

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    DOI: 10.1016/j.isci.2022.104781

  • Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes. International journal

    Seiichi Yano, Takashi Ishiuchi, Shusaku Abe, Satoshi H Namekawa, Gang Huang, Yoshihiro Ogawa, Hiroyuki Sasaki

    Nature communications   13 ( 1 )   4440 - 4440   2022.8

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    DOI: 10.1038/s41467-022-32141-2

  • Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle Invited Reviewed International journal

    Kiyoshi Yoshioka, Hiroshi Nagahisa, Fumihito Miura, Hiromitsu Araki, Yasutomi Kamei, Yasuo Kitajima, Daiki Seko, Jumpei Nogami, Yoshifumi Tsuchiya, Narihiro Okazaki, Akihiko Yonekura, Seigo Ohba, Yoshinori Sumita, Ko Chiba, Kosei Ito, Izumi Asahina, Yoshihiro Ogawa, Takashi Ito, Yasuyuki Ohkawa, Yusuke Ono

    Science Advances   7 ( 24 )   eabd7924 - eabd7924   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/sciadv.abd7924

  • Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle. International journal

    Kiyoshi Yoshioka, Hiroshi Nagahisa, Fumihito Miura, Hiromitsu Araki, Yasutomi Kamei, Yasuo Kitajima, Daiki Seko, Jumpei Nogami, Yoshifumi Tsuchiya, Narihiro Okazaki, Akihiko Yonekura, Seigo Ohba, Yoshinori Sumita, Ko Chiba, Kosei Ito, Izumi Asahina, Yoshihiro Ogawa, Takashi Ito, Yasuyuki Ohkawa, Yusuke Ono

    Science advances   7 ( 24 )   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/sciadv.abd7924

  • Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor. Invited Reviewed International journal

    Yukina Takeichi, Takashi Miyazawa, Shohei Sakamoto, Yuki Hanada, Lixiang Wang, Kazuhito Gotoh, Keiichiro Uchida, Shunsuke Katsuhara, Ryuichi Sakamoto, Takaya Ishihara, Keiji Masuda, Naotada Ishihara, Masatoshi Nomura, Yoshihiro Ogawa

    Diabetologia   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00125-021-05488-2

  • Importance of Intestinal Environment and Cellular Plasticity of Islets in the Development of Postpancreatectomy Diabetes. International journal

    Tatsuya Fukuda, Ryotaro Bouchi, Takato Takeuchi, Kikuko Amo-Shiinoki, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe, Takumi Akashi, Kazuhiro Hirayama, Toshitaka Odamaki, Miki Igarashi, Ikuo Kimura, Katsuya Tanabe, Yukio Tanizawa, Tetsuya Yamada, Yoshihiro Ogawa

    Diabetes care   44 ( 4 )   1002 - 1011   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/dc20-0864

  • Effects of intensive exercise combined with dapagliflozin on body composition in patients with type 2 diabetes: a randomized controlled trial.

    Ryotaro Bouchi, Noriyuki Sonoda, Jun Itoh, Yasuhiro Ono, Tatsuya Fukuda, Takato Takeuchi, Junji Kishimoto, Tetsuya Yamada, Yoshihiro Ogawa

    Endocrine journal   68 ( 3 )   329 - 343   2021.3

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    DOI: 10.1507/endocrj.EJ20-0599

  • Islet cell dedifferentiation is a pathologic mechanism of long-standing progression of type 2 diabetes. International journal

    Kikuko Amo-Shiinoki, Katsuya Tanabe, Yoshinobu Hoshii, Hiroto Matsui, Risa Harano, Tatsuya Fukuda, Takato Takeuchi, Ryotaro Bouchi, Tokiyo Takagi, Masayuki Hatanaka, Komei Takeda, Shigeru Okuya, Wataru Nishimura, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe, Takumi Akashi, Tetsuya Yamada, Yoshihiro Ogawa, Eiji Ikeda, Hiroaki Nagano, Yukio Tanizawa

    JCI insight   6 ( 1 )   2021.1

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    DOI: 10.1172/jci.insight.143791

  • C-type lectin Mincle mediates cell death-triggered inflammation in acute kidney injury. Reviewed International journal

    Miyako Tanaka, Marie Saka-Tanaka, Kozue Ochi, Kumiko Fujieda, Yuki Sugiura, Tomofumi Miyamoto, Hiro Kohda, Ayaka Ito, Taiki Miyazawa, Akira Matsumoto, Seiichiro Aoe, Yoshihiro Miyamoto, Naotake Tsuboi, Shoichi Maruyama, Makoto Suematsu, Sho Yamasaki, Yoshihiro Ogawa, Takayoshi Suganami

    The Journal of experimental medicine   217 ( 11 )   2020.11

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    DOI: 10.1084/jem.20192230

  • MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity. International journal

    Yuki Hanada, Naotada Ishihara, Lixiang Wang, Hidenori Otera, Takaya Ishihara, Takumi Koshiba, Katsuyoshi Mihara, Yoshihiro Ogawa, Masatoshi Nomura

    Nature communications   11 ( 1 )   5711 - 5711   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-020-19287-7

  • Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells. International journal

    Hiroki Inada, Miyako Udono, Kanae Matsuda-Ito, Kenichi Horisawa, Yasuyuki Ohkawa, Shizuka Miura, Takeshi Goya, Junpei Yamamoto, Masao Nagasaki, Kazuko Ueno, Daisuke Saitou, Mikita Suyama, Yoshihiko Maehara, Wataru Kumamaru, Yoshihiro Ogawa, Sayaka Sekiya, Atsushi Suzuki

    Nature communications   11 ( 1 )   5292 - 5292   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-020-19041-z

  • High prevalence of diabetes in patients with primary aldosteronism (PA) associated with subclinical hypercortisolism and prediabetes more prevalent in bilateral than unilateral PA A large, multicenter cohort study in Japan Reviewed

    , Yuko Akehi, Toshihiko Yanase, Ryoko Motonaga, Hironobu Umakoshi, Mika Tsuiki, Yoshiyu Takeda, Takashi Yoneda, Isao Kurihara, Hiroshi Itoh, Takuyuki Katabami, Takamasa Ichijo, Norio Wada, Yui Shibayama, Takanobu Yoshimoto, Kenji Ashida, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Katsutoshi Takahashi, Megumi Fujita, Minemori Watanabe, Yuichi Matsuda, Hiroki Kobayashi, Hirotaka Shibata, Kohei Kamemura, Michio Otsuki, Yuichi Fujii, Koichi Yamamoto, Atsushi Ogo, Shintaro Okamura, Shozo Miyauchi, Tomikazu Fukuoka, Shoichiro Izawa, Shigeatsu Hashimoto, Masanobu Yamada, Yuichiro Yoshikawa, Tatsuya Kai, Tomoko Suzuki, Takashi Kawamura, Mitsuhide Naruse

    Diabetes care   42 ( 5 )   938 - 945   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/dc18-1293

  • Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood Reviewed

    Xunmei Yuan, Kazutaka Tsujimoto, Koshi Hashimoto, Kenichi Kawahori, Nozomi Hanzawa, Miho Hamaguchi, Takami Seki, Makiko Nawa, Tatsuya Ehara, Yohei Kitamura, Izuho Hatada, Morichika Konishi, Nobuyuki Itoh, Yoshimi Nakagawa, Hitoshi Shimano, Takako Takai-Igarashi, Yasutomi Kamei, Yoshihiro Ogawa

    Nature communications   9 ( 1 )   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-018-03038-w

  • Mild maternal hypothyroxinemia during pregnancy induces persistent DNA hypermethylation in the hippocampal brain-derived neurotrophic factor gene in mouse offspring. Reviewed International journal

    K. Kawahori, K. Hashimoto, X. Yuan, K. Tsujimoto, N. Hanzawa, M. Hamaguchi, S. Kase, K. Fujita, K. Tagawa, H. Okazawa, Y. Nakajima, N. Shibusawa, M. Yamada, and Y. Ogawa.

    Thyroid   28 ( 3 )   395 - 406   2018.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/thy.2017.0331.

  • Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood. Invited Reviewed International journal

    X. Yuan, K. Tsujimoto, K. Hashimoto, K. Kawahori, N. Hanzawa, M. Hamaguchi, T. Seki, M. Nawa, T. Ehara, Y. Kitamura, I. Hatada, M. Konishi, N. Itoh, Y. Nakagawa, H. Shimano, T. Takai-Igarashi, Y. Kamei, and Y. Ogawa.

    Nat. Commun.   9   e636   2018.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-018-03038-w.

  • Canagliflozin, an SGLT2 inhibitor, attenuates the development of hepatocellular carcinoma in a mouse model of human NASH. Reviewed International journal

    K. Shiba, K. Tsuchiya, C. Komiya, Y. Miyachi, K. Mori, N. Shimazu, S. Yamaguchi, N. Ogasawara, M. Katoh, M. Itoh, T. Suganami, and Y. Ogawa.

    Sci. Rep.   8   e2362   2018.1

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  • Sialic acid-binding immunoglobulin-like lectin1 as a novel predictive biomarker for relapse in Graves’ disease: a multicenter study. Reviewed International journal

    28 ( 1 )   50 - 59   2018.1

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    DOI: 10.1089/thy

  • Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3) an open-label, randomised controlled trial Reviewed

    Kohjiro Ueki, Takayoshi Sasako, Yukiko Okazaki, Masayuki Kato, Sumie Okahata, Hisayuki Katsuyama, Mikiko Haraguchi, Ai Morita, Ken Ohashi, Kazuo Hara, Atsushi Morise, Kazuo Izumi, Naoki Ishizuka, Yasuo Ohashi, Mitsuhiko Noda, Takashi Kadowaki, Masakazu Haneda, Yasunori Iwashima, Toshihiro Suda, Naoki Tamasawa, Makoto Daimon, Jo Satoh, Noriko Takebe, Yasushi Ishigaki, Tsuyoshi Watanabe, Hiroaki Satoh, Kikuo Kasai, Yoshimasa Aso, Shun Ishibashi, Shigehiro Katayama, San e. Ishikawa, Masafumi Kakei, Kazuyuki Namai, Naotake Hashimoto, Yoshifumi Suzuki, Shunichiro Onishi, Koutaro Yokote, Masafumi Matsuda, Masahiro Masuzawa, Yoichi Hayashi, Satoshi Saito, Norikazu Ogihara, Hisamitsu Ishihara, Naoko Tajima, Kazunori Utsunomiya, Akira Shimada, Hiroshi Itoh, Ryuzo Kawamori, Hirotaka Watada, Michio Hayashi, Yasumichi Mori, Teruo Shiba, Akihiro Isogawa, Hiroshi Sakura, Masato Odawara, Kazuyuki Tobe, Kazuhisa Tsukamoto, Toshimasa Yamauchi, Tamio Teramoto, Yukio Hirata, Isao Uchimura, Yoshihiro Ogawa, Gen Yoshino, Takahisa Hirose, Hiroshi Kajio, Yoshihito Atsumi, Akira Shimada, Yoichi Oikawa, Atsushi Araki, Akio Ueki, Atsushi Ohno, Masafumi Kitaoka, Yoshikuni Fujita, Tatsumi Moriya, Taiki Tojo, Masayoshi Shichiri, Daisuke Suzuki, Masao Toyoda, Kumiko Hamano, Rieko Komi, Yasuo Terauchi, Nobuaki Kuzuya, Masayo Yamada, Toshinari Takamura, Mitsuo Imura, Hiroshi Tanaka, Masayuki Hayashi, Yasuhisa Kato, Mitsuyasu Itoh, Atsushi Suzuki, Mikihiro Nakayama, Takahisa Sano, Eitaro Nakashima, Yasuhiro Sumida, Yutaka Yano, Tsuyoshi Tanaka, Kazuya Murata, Atsunori Kashiwagi, Hiroshi Maegawa, Shigeo Kono, Nobuya Inagaki, Keisuke Kosugi, Tetsuyuki Yasuda, Yasunao Yoshimasa, Ichiro Kishimoto, Toshihiko Sato, Masayuki Hosoi, Tomoyuki Yamasaki, Munehide Matsuhisa, Iichiro Shimomura, Ataru Taniguchi, Akira Kuroe, Takeshi Kurose, Takeshi Ohara, Kazuhiko Sakaguchi, Mitsuyoshi Namba, Kohei Kaku, Masazumi Fujiwara, Ikki Shimizu, Keizo Ono, Osamu Ebisui, Yukio Tanizawa, Yosuke Okada, Shoichi Natori, Takehiko Kodera, Naoichi Sato, Makoto Ide, Kentaro Yamada, Fumio Umeda, Shoichi Natori, Tomoaki Eto, Kazuo Mimura, Shinsuke Hiramatsu, Tomoaki Inoue, Ryoko Takei, Atsushi Ogo, Katsumi Eguchi, Eiji Kawasaki, Yuji Koide, Eiichi Araki, Hideaki Jinnouchi, Hiroaki Yamamoto, Mitsutaka Motoyoshi, Toru Hiyoshi, Yasushi Tanaka, Tadahisa Momoki, Koichiro Sato, Akihiko Yoneyama, Kenichi Ito, Hiroshi Sobajima, Hiroshi Ikegami, Masaki Ikeda, Hiroki Ikeda, Kenji Takahashi, Hirofumi Makino, Yasuo Ueda, Masamitsu Nakazato

    The Lancet Diabetes and Endocrinology   5 ( 12 )   951 - 964   2017.12

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    DOI: 10.1016/S2213-8587(17)30327-3

  • CD11c+ resident macrophages drive hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis Reviewed

    Michiko Itoh, Takayoshi Suganami, Hideaki Kato, Sayaka Kanai, Ibuki Shirakawa, Takeru Sakai, Toshihiro Goto, Masahiro Asakawa, Isao Hidaka, Hiroshi Sakugawa, Koji Ohnishi, Yoshihiro Komohara, Kenichi Asano, Isao Sakaida, Masato Tanaka, Yoshihiro Ogawa

    JCI Insight   2 ( 22 )   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1172/jci.insight.92902

  • Synthetic "smart gel" provides glucose-responsive insulin delivery in diabetic mice Reviewed

    Akira Matsumoto, Miyako Tanaka, Hiroko Matsumoto, Kozue Ochi, Yuki Moro-Oka, Hirohito Kuwata, Hironori Yamada, Ibuki Shirakawa, Taiki Miyazawa, Hitoshi Ishii, Kazunori Kataoka, Yoshihiro Ogawa, Yuji Miyahara, Takayoshi Suganami

    Science Advances   3 ( 11 )   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/sciadv.aaq0723

  • Activation of SF1 neurons in the ventromedial hypothalamus by DREADD technology increases insulin sensitivity in peripheral tissues Reviewed

    Eulalia A. Coutinho, Shiki Okamoto, Ayako Wendy Ishikawa, Shigefumi Yokota, Nobuhiro Wada, Takahiro Hirabayashi, Kumiko Saito, Tatsuya Sato, Kazuyo Takagi, Chen Chi Wang, Kenta Kobayashi, Yoshihiro Ogawa, Seiji Shioda, Yumiko Yoshimura, Yasuhiko Minokoshi

    Diabetes   66 ( 9 )   2372 - 2386   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/db16-1344

  • YAP determines the cell fate of injured mouse hepatocytes in vivo Reviewed

    Norio Miyamura, Shoji Hata, Tohru Itoh, Minoru Tanaka, Miki Nishio, Michiko Itoh, Yoshihiro Ogawa, Shuji Terai, Isao Sakaida, Akira Suzuki, Atsushi Miyajima, Hiroshi Nishina

    Nature communications   8   2017.7

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    DOI: 10.1038/ncomms16017

  • Roles for Cell-Cell Adhesion and Contact in Obesity-Induced Hepatic Myeloid Cell Accumulation and Glucose Intolerance Reviewed

    Yasutaka Miyachi, Kyoichiro Tsuchiya, Chikara Komiya, Kumiko Shiba, Noriko Shimazu, Shinobu Yamaguchi, Michiyo Deushi, Mizuko Osaka, Kouji Inoue, Yuta Sato, Sayaka Matsumoto, Junichi Kikuta, Kenjiro Wake, Masayuki Yoshida, Masaru Ishii, Yoshihiro Ogawa

    Cell Reports   18 ( 11 )   2766 - 2779   2017.3

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    DOI: 10.1016/j.celrep.2017.02.039

  • Ligand-activated PPARα-dependent DNA demethylation regulates the fatty acid β-oxidation genes in the postnatal liver Reviewed

    64 ( 3 )   775 - 784   2015.3

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    The metabolic function of the liver changes sequentially during early life in mammals to adapt to the marked changes in nutritional environment. Accordingly, hepatic fatty acid β-oxidation is activated after birth to produce energy from breast milk lipids. However, how it is induced during the neonatal period is poorly understood. Here we show DNA demethylation and increased mRNA expression of the fatty acid β-oxidation genes in the postnatal mouse liver. The DNA demethylation does not occur in the fetal mouse liver under the physiologic condition, suggesting that it is specific to the neonatal period. Analysis of mice deficient in the nuclear receptor peroxisome proliferator-activated receptor a (PPARα) and maternal administration of a PPARα ligand during the gestation and lactation periods reveal that the DNA demethylation is PPARα dependent. We also find that DNA methylation of the fatty acid β-oxidation genes are reduced in the adult human liver relative to the fetal liver. This study represents the first demonstration that the ligand-activated PPARα-dependent DNA demethylation regulates the hepatic fatty acid β-oxidation genes during the neonatal period, thereby highlighting the role of a lipid-sensing nuclear receptor in the gene- and lifestage- specific DNA demethylation of a particular metabolic pathway.

    DOI: 10.2337/db14-0158

  • ATM Regulates Adipocyte Differentiation and Contributes to Glucose Homeostasis Reviewed

    Masatoshi Takagi, Hatsume Uno, Rina Nishi, Masataka Sugimoto, Setsuko Hasegawa, Jinhua Piao, Norimasa Ihara, Sayaka Kanai, Saori Kakei, Yoshifumi Tamura, Takayoshi Suganami, Yasutomi Kamei, Toshiaki Shimizu, Akio Yasuda, Yoshihiro Ogawa, Shuki Mizutani

    Cell Reports   10 ( 6 )   957 - 967   2015.2

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    DOI: 10.1016/j.celrep.2015.01.027

  • Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis Reviewed

    Miyako Tanaka, Kenji Ikeda, Takayoshi Suganami, Chikara Komiya, Kozue Ochi, Ibuki Shirakawa, Miho Hamaguchi, Satoshi Nishimura, Ichiro Manabe, Takahisa Matsuda, Kumi Kimura, Hiroshi Inoue, Yutaka Inagaki, Seiichiro Aoe, Sho Yamasaki, Yoshihiro Ogawa

    Nature communications   5   2014.9

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    DOI: 10.1038/ncomms5982

  • Endothelial PGC-1α mediates vascular dysfunction in diabetes Reviewed

    19 ( 2 )   246 - 258   2014.2

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    Endothelial dysfunction is a central hallmark of diabetes. The transcriptional coactivator PGC-1α is a powerful regulator of metabolism, but its role in endothelial cells remains poorly understood. We show here that endothelial PGC-1α expression is high in diabetic rodents and humans and that PGC-1α powerfully blocks endothelial migration in cell culture and vasculogenesis in vivo. Mechanistically, PGC-1α induces Notch signaling, blunts activation of Rac/Akt/eNOS signaling, and renders endothelial cells unresponsive to established angiogenic factors. Transgenic overexpression of PGC-1α in the endothelium mimics multiple diabetic phenotypes, including aberrant re-endothelialization after carotid injury, blunted wound healing, and reduced blood flow recovery after hindlimb ischemia. Conversely, deletion of endothelial PGC-1α rescues the blunted wound healing and recovery from hindlimb ischemia seen in type 1 and type 2 diabetes. Endothelial PGC-1α thus potently inhibits endothelial function and angiogenesis, and induction of endothelial PGC-1α contributes to multiple aspects of vascular dysfunction in diabetes.

    DOI: 10.1016/j.cmet.2013.12.014

  • Activating transcription factor 4 links metabolic stress to interleukin-6 expression in macrophages Reviewed

    Yorihiro Iwasaki, Takayoshi Suganami, Rumi Hachiya, Ibuki Shirakawa, Misa Kim-Saijo, Miyako Tanaka, Miho Hamaguchi, Takako Takai-Igarashi, Michikazu Nakai, Yoshihiro Miyamoto, Yoshihiro Ogawa

    Diabetes   63 ( 1 )   152 - 161   2014.1

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    DOI: 10.2337/db13-0757

  • Activin receptor-like kinase 7 suppresses lipolysis to accumulate fat in obesity through downregulation of peroxisome proliferator-activated receptor γ and C/EBPα Reviewed

    62 ( 1 )   115 - 123   2013.1

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    We previously identified a quantitative trait locus for adiposity, non-insulin-dependent diabetes 5 (Nidd5), on mouse chromosome 2. In the current study, we identified the actual genetic alteration at Nidd5 as a nonsense mutation of the Acvr1c gene encoding activin receptor-like kinase 7 (ALK7), one of the type I transforming growth factor-β receptors, which results in a COOH-terminal deletion of the kinase domain. We further showed that the ALK7 dysfunction causes increased lipolysis in adipocytes and leads to decreased fat accumulation. Conversely, ALK7 activation inhibits lipolysis by suppressing the expression of adipose lipases. ALK7 and activated Smads repress those lipases by downregulating peroxisome proliferator-activated receptor γ ( PPAR γ) and CCAAT/enhancer binding protein (C/EBP) α. Although PPARγ and C/EBPα act as adipogenic transcription factors during adipocyte differentiation, they are lipolytic in sum in differentiated adipocytes and are downregulated by ALK7 in obesity to accumulate fat. Under the obese state, ALK7 deficiency improves glucose tolerance and insulin sensitivity by preferentially increasing fat combustion in mice. These findings have uncovered a net lipolytic function of PPARγ and C/EBPα in differentiated adipocytes and point to the ALK7-signaling pathway that is activated in obesity as a potential target of medical intervention.

    DOI: 10.2337/db12-0295

  • Highly purified eicosapentaenoic acid increases interleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia Reviewed

    Noriko Satoh-Asahara, Akira Shimatsu, Yousuke Sasaki, Hidenori Nakaoka, Akihiro Himeno, Mayu Tochiya, Shigeo Kono, Tomohide Takaya, Koh Ono, Hiromichi Wada, Takayoshi Suganami, Koji Hasegawa, Yoshihiro Ogawa

    Diabetes care   35 ( 12 )   2631 - 2639   2012.12

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    DOI: 10.2337/dc12-0269

  • Role of DNA methylation in the regulation of lipogenic glycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver Reviewed

    Tatsuya Ehara, Yasutomi Kamei, Mayumi Takahashi, Xunmei Yuan, Sayaka Kanai, Erina Tamura, Miyako Tanaka, Tomomi Yamazaki, Shinji Miura, Osamu Ezaki, Takayoshi Suganami, Masaki Okano, Yoshihiro Ogawa

    Diabetes   61 ( 10 )   2442 - 2450   2012.10

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    DOI: 10.2337/db11-1834

  • Exacerbation of diabetic nephropathy by Hyperlipidaemia is mediated by Toll-like receptor 4 in mice Reviewed

    T. Kuwabara, K. Mori, M. Mukoyama, M. Kasahara, H. Yokoi, Y. Saito, Y. Ogawa, H. Imamaki, T. Kawanishi, A. Ishii, K. Koga, K. P. Mori, Y. Kato, A. Sugawara, K. Nakao

    Diabetologia   55 ( 8 )   2256 - 2266   2012.8

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    DOI: 10.1007/s00125-012-2578-1

  • The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation Reviewed

    Yasuharu Watanabe, Tomoya Nakamura, Sho Ishikawa, Shiho Fujisaka, Isao Usui, Koichi Tsuneyama, Yoshinori Ichihara, Tsutomu Wada, Yoichiro Hirata, Takayoshi Suganami, Hirofumi Izaki, Shizuo Akira, Kensuke Miyake, Hiro Omi Kanayama, Michio Shimabukuro, Masataka Sata, Toshiyasu Sasaoka, Yoshihiro Ogawa, Kazuyuki Tobe, Kiyoshi Takatsu, Yoshinori Nagai

    Diabetes   61 ( 5 )   1199 - 1209   2012.5

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    DOI: 10.2337/db11-1182

  • Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans Reviewed

    Masayuki Ichioka, Takayoshi Suganami, Naoto Tsuda, Ibuki Shirakawa, Yoichiro Hirata, Noriko Satoh-Asahara, Yuri Shimoda, Miyako Tanaka, Misa Kim-Saijo, Yoshihiro Miyamoto, Yasutomi Kamei, Masataka Sata, Yoshihiro Ogawa

    Diabetes   60 ( 3 )   819 - 826   2011.3

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    DOI: 10.2337/db10-0864

  • Antiobesity effect of eicosapentaenoic acid in high-fat/high-sucrose diet-induced obesity Importance of hepatic lipogenesis Reviewed

    Ayumi Sato, Hiroyuki Kawano, Tatsuto Notsu, Masahiko Ohta, Masanori Nakakuki, Kiyoshi Mizuguchi, Michiko Itoh, Takayoshi Suganami, Yoshihiro Ogawa

    Diabetes   59 ( 10 )   2495 - 2504   2010.10

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    DOI: 10.2337/db09-1554

  • Unbalanced M1/M2 phenotype of peripheral blood monocytes in obese diabetic patients Effect of pioglitazone Reviewed

    Noriko Satoh, Akira Shimatsu, Akihiro Himeno, Yousuke Sasaki, Hajime Yamakage, Kazunori Yamada, Takayoshi Suganami, Yoshihiro Ogawa

    Diabetes care   33 ( 1 )   e7   2010.1

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    DOI: 10.2337/dc09-1315

  • Purified eicosapentaenoic acid reduces small dense LDL, remnant lipoprotein particles, and C-reactive protein in metabolic syndrome Reviewed

    Noriko Satoh, Akira Shimatsu, Kazuhiko Kotani, Naoki Sakane, Kazunori Yamada, Takayoshi Suganami, Hideshi Kuzuya, Yoshihiro Ogawa

    Diabetes care   30 ( 1 )   144 - 146   2007.1

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    DOI: 10.2337/dc06-1179

  • Role of the Toll-like receptor 4/NF-κB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages Reviewed

    27 ( 1 )   84 - 91   2007.1

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    OBJECTIVE - Previous studies demonstrated that obese adipose tissue is characterized by increased infiltration of macrophages, suggesting that they might represent an important source of inflammation. Using an in vitro coculture system composed of 3T3-L1 adipocytes and RAW264 macrophages, we previously demonstrated that saturated fatty acids (FAs) and tumor necrosis factor (TNF)-α derived from adipocytes and macrophages, respectively, play a major role in the coculture-induced inflammatory changes. METHODS AND RESULTS - Coculture of adipocytes and macrophages resulted in the activation of nuclear factor-κB (NF-κB), a primary regulator of inflammatory responses, in both cell types. Pharmacological inhibition of NF-κB markedly suppressed the coculture-induced production of proinflammatory cytokines and adipocyte lipolysis. Peritoneal macrophages obtained from Toll-like receptor 4 (TLR4) mutant mice exhibited marked attenuation of TNFα production in response to saturated FAs. Notably, coculture of hypertrophied adipocytes and TLR4-mutant macrophages resulted in marked inhibition of proinflammatory cytokine production and adipocyte lipolysis. We also observed that endogenous FAs, which are released from adipocytes via the β3-adrenergic stimulation, resulted in the activation of the TLR4/NF-κB pathway. CONCLUSION - These findings suggest that saturated FAs, which are released in large quantities from hypertrophied adipocytes via the macrophage-induced adipocyte lipolysis, serve as a naturally occurring ligand for TLR4, thereby inducing the inflammatory changes in both adipocytes and macrophages through NF-κB activation.

    DOI: 10.1161/01.ATV.0000251608.09329.9a

  • Increase in glucose-6-phosphate dehydrogenase in adipocytes stimulates oxidative stress and inflammatory signals Reviewed

    Jiyoung Park, Sik Choe Sung, A. Hyun Choi, Ho Kim Kang, Jin Yoon Myeong, Takayoshi Suganami, Yoshihiro Ogawa, Bum Kim Jae

    Diabetes   55 ( 11 )   2939 - 2949   2006.11

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    DOI: 10.2337/db05-1570

  • Transgenic overexpression of brain natriuretic peptide prevents the progression of diabetic nephropathy in mice Reviewed

    H. Makino, M. Mukoyama, K. Mori, T. Suganami, M. Kasahara, K. Yahata, T. Nagae, H. Yokoi, K. Sawai, Y. Ogawa, S. Suga, Y. Yoshimasa, A. Sugawara, I. Tanaka, K. Nakao

    Diabetologia   49 ( 10 )   2514 - 2524   2006.10

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    DOI: 10.1007/s00125-006-0352-y

  • A paracrine loop between adipocytes and macrophages aggravates inflammatory changes Role of free fatty acids and tumor necrosis factor α Reviewed

    25 ( 10 )   2062 - 2068   2005.10

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    Objective - Weight gain is associated with infiltration of fat by macrophages, suggesting that they are an important source of inflammation in obese adipose tissue. Here we developed an in vitro coculture system composed of adipocytes and macrophages and examined the molecular mechanism whereby these cells communicate. Methods and Results - Coculture of differentiated 3T3-L1 adipocytes and macrophage cell line RAW264 results in the marked upregulation of proinflammatory cytokines, such as tumor necrosis factor α(TNF-α), and the downregulation of the antiinflammatory cytokine adiponectin. Such inflammatory changes are induced by the coculture without direct contact, suggesting the role of soluble factors. A neutralizing antibody to TNF-α, which occurs mostly in macrophages, inhibits the inflammatory changes in 3T3-L1, suggesting that TNF-α is a major macrophage-derived mediator of inflammation in adipocytes. Conversely, free fatty acids (FFAs) may be important adipocyte-derived mediators of inflammation in macrophages, because the production of TNF-α in RAW264 is markedly increased by palmitate, a major FFA released from 3T3-L1. The inflammatory changes in the coculture are augmented by use of either, hypertrophied 3T3-L1 or adipose stromal vascular fraction obtained from obese ob/ob mice. Conclusions - We postulate that a paracrine loop involving FFAs and TNF-α between adipocytes and macrophages establishes a vicious cycle that aggravates inflammatory changes in the adipose tissue.

    DOI: 10.1161/01.ATV.0000183883.72263.13

  • Skeletal muscle AMP-activated protein kinase phosphorylation parallels metabolic phenotype in leptin transgenic mice under dietary modification Reviewed

    Tomohiro Tanaka, Shuji Hidaka, Hiroaki Masuzaki, Shintaro Yasue, Yasuhiko Minokoshi, Ken Ebihara, Hideki Chusho, Yoshihiro Ogawa, Taro Toyoda, Kenji Sato, Fumiko Miyanaga, Muneya Fujimoto, Tsutomu Tomita, Toru Kusakabe, Nozomi Kobayashi, Hideki Tanioka, Tatsuya Hayashi, Kiminori Hosoda, Hironobu Yoshimatsu, Toshiie Sakata, Kazuwa Nakao

    Diabetes   54 ( 8 )   2365 - 2374   2005.8

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    DOI: 10.2337/diabetes.54.8.2365

  • Role of premature leptin surge in obesity resulting from intrauterine undernutrition Reviewed

    Shigeo Yura, Hiroaki Itoh, Norimasa Sagawa, Hiroshi Yamamoto, Hiroaki Masuzaki, Kazuwa Nakao, Makoto Kawamura, Maki Takemura, Kazuyo Kakui, Yoshihiro Ogawa, Shingo Fujii

    Cell metabolism   1 ( 6 )   371 - 378   2005.6

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    DOI: 10.1016/j.cmet.2005.05.005

  • Angiopoietin-related growth factor antagonizes obesity and insulin resistance Reviewed

    Yuichi Oike, Masaki Akao, Kunio Yasunaga, Toshimasa Yamauchi, Tohru Morisada, Yasuhiro Ito, Takashi Urano, Yoshishige Kimura, Yoshiaki Kubota, Hiromitsu Maekawa, Takeshi Miyamoto, Keishi Miyata, Shun Ichiro Matsumoto, Jura Sakai, Naomi Nakagata, Motohiro Takeya, Haruhiko Koseki, Yoshihiro Ogawa, Takashi Kadowaki, Toshio Suda

    Nature medicine   11 ( 4 )   400 - 408   2005.4

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    DOI: 10.1038/nm1214

  • Overexpression of brain natriuretic peptide facilitates neutrophil infiltration and cardiac matrix metalloproteinase-9 expression after acute myocardial infarction Reviewed

    Rika Kawakami, Yoshihiko Saito, Ichiro Kishimoto, Masaki Harada, Koichiro Kuwahara, Nobuki Takahashi, Yasuaki Nakagawa, Michio Nakanishi, Keiji Tanimoto, Satoru Usami, Shinji Yasuno, Hideyuki Kinoshita, Hideki Chusho, Naohisa Tamura, Yoshihiro Ogawa, Kazuwa Nakao

    Circulation   110 ( 21 )   3306 - 3312   2004.11

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    DOI: 10.1161/01.CIR.0000147829.78357.C5

  • Leptin-to-adiponectin ratio as a potential atherogenic index in obese type 2 diabetic patients Reviewed

    Noriko Satoh, Mitsuhide Naruse, Takeshi Usui, Tetsuya Tagami, Takayoshi Suganami, Kazunori Yamada, Hideshi Kuzuya, Akira Shimatsu, Yoshihiro Ogawa

    Diabetes care   27 ( 10 )   2488 - 2490   2004.10

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    DOI: 10.2337/diacare.27.10.2488

  • Leptin stimulates ischemia-induced retinal neovascularization Possible role of vascular endothelial growth factor expressed in retinal endothelial cells Reviewed

    Eri Suganami, Hitoshi Takagi, Hirokazu Ohashi, Kiyoshi Suzuma, Izumi Suzuma, Hideyasu Oh, Daisuke Watanabe, Tomonari Ojima, Takayoshi Suganami, Yasushi Fujio, Kazuwa Nakao, Yoshihiro Ogawa, Nagahisa Yoshimura

    Diabetes   53 ( 9 )   2443 - 2448   2004.9

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    DOI: 10.2337/diabetes.53.9.2443

  • Serum leptin level is a regulator of bone mass Reviewed

    F. Elefteriou, S. Takeda, K. Ebihara, J. Magre, N. Patano, C. Ae Kim, Y. Ogawa, X. Liu, S. M. Ware, W. J. Craigen, J. J. Robert, C. Vinson, K. Nakao, J. Capeau, G. Karsenty

    Proceedings of the National Academy of Sciences of the United States of America   101 ( 9 )   3258 - 3263   2004.3

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    DOI: 10.1073/pnas.0308744101

  • Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway Reviewed

    Akihiro Yasoda, Yasato Komatsu, Hideki Chusho, Takashi Miyazawa, Ami Ozasa, Masako Miura, Tatsuya Kurihara, Tomohiro Rogi, Shoji Tanaka, Michio Suda, Naohisa Tamura, Yoshihiro Ogawa, Kazuwa Nakao

    Nature medicine   10 ( 1 )   80 - 86   2004.1

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    DOI: 10.1038/nm971

  • Antiatherogenic effect of pioglitazone in type 2 diabetic patients irrespective of the responsiveness to its antidiabetic effect Reviewed

    Noriko Satoh, Yoshihiro Ogawa, Takeshi Usui, Tetsuya Tagami, Shigeo Kono, Hiroko Uesugi, Hiroyuki Sugiyama, Akira Sugawara, Kazunori Yamada, Akira Shimatsu, Hideshi Kuzuya, Kazuwa Nakao

    Diabetes care   26 ( 9 )   2493 - 2499   2003.9

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    DOI: 10.2337/diacare.26.9.2493

  • A novel homozygous missence mutation of melanocortin-4 receptor (MC4R) in a Japanese woman with obesity Reviewed

    Hiromasa Kobayashi, Yoshihiro Ogawa, Mitsuyo Shintani, Ken Ebihara, Makiko Shimodahira, Toshio Iwakura, Megumu Hino, Takashi Ishihara, Katsuji Ikekubo, Hiroyuki Kurahachi, Kazuwa Nakao

    Diabetes   51 ( 1 )   243 - 246   2002.1

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    DOI: 10.2337/diabetes.51.1.243

  • Troglitazone Not only Increases GLUT4 but Also Induces Its Translocation in Rat Adipocytes Reviewed

    Mitsuyo Shintani, Haruo Nishimura, Shin Yonemitsu, Yoshihiro Ogawa, Tatsuya Hayashi, Kiminori Hosoda, Gen Inoue, Kazuwa Nakao

    Diabetes   50 ( 10 )   2296 - 2300   2001.10

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    DOI: 10.2337/diabetes.50.10.2296

  • Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes Reviewed

    Ken Ebihara, Yoshihiro Ogawa, Hiroaki Masuzaki, Mitsuyo Shintani, Fumiko Miyanaga, Megumi Aizawa-Abe, Tatsuya Hayashi, Kiminori Hosoda, Gen Inoue, Yasunao Yoshimasa, Oksana Gavrilova, Marc L. Reitman, Kazuwa Nakao

    Diabetes   50 ( 6 )   1440 - 1448   2001.6

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    DOI: 10.2337/diabetes.50.6.1440

  • Dwarfism and early death in mice lacking C-type natriuretic peptide Reviewed

    Hideki Chusho, Naohisa Tamura, Yoshihiro Ogawa, Akihiro Yasoda, Michio Suda, Takashi Miyazawa, Kenji Nakamura, Kazuki Nakao, Tatsuya Kurihara, Yasato Komatsu, Hiroshi Itoh, Kiyoshi Tanaka, Yoshihiko Saito, Motoya Katsuki, Kazuwa Nakao

    Proceedings of the National Academy of Sciences of the United States of America   98 ( 7 )   4016 - 4021   2001.3

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    DOI: 10.1073/pnas.071389098

  • Attractin/mahogany/zitter plays a critical role in myelination of the central nervous system Reviewed

    Takashi Kuramoto, Kazuhiro Kitada, Toshihide Inui, Yoshifumi Sasaki, Kazumi Ito, Takao Hase, Saburo Kawagachi, Yoshihiro Ogawa, Kazuwa Nakao, Gregory S. Barsh, Minako Nagao, Toshikazu Ushijima, Tadao Serikawa

    Proceedings of the National Academy of Sciences of the United States of America   98 ( 2 )   559 - 564   2001.1

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    DOI: 10.1073/pnas.98.2.559

  • Troglitazone induces GLUT4 translocation in L6 myotubes Reviewed

    Shin Yonemitsu, Haruo Nishimura, Mitsuyo Shintani, Ryou Inoue, Yuji Yamamoto, Hiroaki Masuzaki, Yoshihiro Ogawa, Kiminori Hosoda, Gen Inoue, Tatsuya Hayashi, Kazuwa Nakao

    Diabetes   50 ( 5 )   1093 - 1101   2001.1

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    DOI: 10.2337/diabetes.50.5.1093

  • Rapid publication ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway Reviewed

    Mitsuyo Shintani, Yoshihiro Ogawa, Ken Ebihara, Megumi Aizawa-Abe, Fumiko Miyanaga, Kazuhiko Takaya, Tatsuya Hayashi, Gen Inoue, Kiminori Hosoda, Masayasu Kojima, Kenji Kangawa, Kazuwa Nakao

    Diabetes   50 ( 2 )   227 - 232   2001.1

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    DOI: 10.2337/diabetes.50.2.227

  • Pathophysiological role of leptin in obesity-related hypertension Reviewed

    Megumi Aizawa-Abe, Yoshihiro Ogawa, Hiroaki Masuzaki, Ken Ebihara, Noriko Satoh, Hidenori Iwai, Naoki Matsuoka, Tatsuya Hayashi, Kiminori Hosoda, Gen Inoue, Yasunao Yoshimasa, Kazuwa Nakao

    Journal of Clinical Investigation   105 ( 9 )   1243 - 1252   2000.5

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    DOI: 10.1172/JCI8341

  • Cardiac fibrosis in mice lacking brain natriuretic peptide Reviewed

    Naohisa Tamura, Yoshihiro Ogawa, Hideki Chusho, Kenji Nakamura, Kazuki Nakao, Michio Suda, Masato Kasahara, Ryuju Hashimoto, Goro Katsuura, Masashi Mukoyama, Hiroshi Itoh, Yoshihiko Saito, Issei Tanaka, Hiroki Otani, Motoya Katsuki, Kazuwa Nakao

    Proceedings of the National Academy of Sciences of the United States of America   97 ( 8 )   4239 - 4244   2000.4

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    DOI: 10.1073/pnas.070371497

  • Accelerated puberty and late-onset hypothalamic hypogonadism in female transgenic skinny mice overexpressing leptin Reviewed

    Shigeo Yura, Yoshihiro Ogawa, Norimasa Sagawa, Hiroaki Masuzaki, Hiroaki Itoh, Ken Ebihara, Megumi Aizawa-Abe, Shingo Fujii, Kazuwa Nakao

    Journal of Clinical Investigation   105 ( 6 )   749 - 755   2000.3

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    DOI: 10.1172/JCI8353

  • Constitutively active mitogen-activated protein kinase kinase increases GLUT1 expression and recruits both GLUT1 and GLUT4 at the cell surface in 3T3-L1 adipocytes Reviewed

    Yuji Yamamoto, Yasunao Yoshimasa, Makoto Koh, Junko Suga, Hiroaki Masuzaki, Yoshihiro Ogawa, Kiminori Hosoda, Haruo Nishimura, Yoshihiko Watanabe, Gen Inoue, Kazuwa Nakao

    Diabetes   49 ( 3 )   332 - 339   2000.3

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    DOI: 10.2337/diabetes.49.3.332

  • Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action Reviewed

    Ken Ebihara, Yoshihiro Ogawa, Goro Katsuura, Yoshito Numata, Hiroaki Masuzaki, Noriko Satoh, Mikio Tamaki, Takeshi Yoshioka, Minoru Hayase, Naoki Matsuoka, Megumi Aizawa-Abe, Yasunao Yoshimasa, Kazuwa Nakao

    Diabetes   48 ( 10 )   2028 - 2033   1999.10

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    DOI: 10.2337/diabetes.48.10.2028

  • Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin Reviewed

    Yoshihiro Ogawa, Hiroaki Masuzaki, Kiminori Hosoda, Megumi Aizawa-Abe, Junko Suga, Michio Suda, Ken Ebihara, Hidenori Iwai, Naoki Matsuoka, Noriko Satoh, Hiroyuki Odaka, Hisao Kasuga, Yukio Fujisawa, Gen Inoue, Haruo Nishimura, Yasunao Yoshimasa, Kazuwa Nakao

    Diabetes   48 ( 9 )   1822 - 1829   1999.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2337/diabetes.48.9.1822

  • Sympathetic activation of leptin via the ventromedial hypothalamus Leptin-induced increase in catecholamine secretion Reviewed

    Noriko Satoh, Yoshihiro Ogawa, Goro Katsuura, Yoshito Numata, Tetsuo Tsuji, Minoru Hayase, Ken Ebihara, Hiroaki Masuzaki, Kiminori Hosoda, Yasunao Yoshimasa, Kazuwa Nakao

    Diabetes   48 ( 9 )   1787 - 1793   1999.9

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    DOI: 10.2337/diabetes.48.9.1787

  • Changes in intra-abdominal visceral fat and serum leptin levels in patients with obstructive sleep apnea syndrome following nasal continuous positive airway pressure therapy Reviewed

    Kazuo Chin, Kouichi Shimizu, Takaya Nakamura, Noboru Narai, Hiroaki Masuzaki, Yoshihiro Ogawa, Michiaki Mishima, Takashi Nakamura, Kazuwa Nakao, Motoharu Ohi

    Circulation   100 ( 7 )   706 - 712   1999.8

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    DOI: 10.1161/01.CIR.100.7.706

  • Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal yellow agouti mutation Usefulness of leptin for the treatment of obesity-associated diabetes Reviewed

    Hiroaki Masuzaki, Yoshihiro Ogawa, Megumi Aizawa-Abe, Kiminori Hosoda, Junko Suga, Ken Ebihara, Noriko Satoh, Hidenori Iwai, Gen Inoue, Haruo Nishimura, Yasunao Yoshimasa, Kazuwa Nakao

    Diabetes   48 ( 8 )   1615 - 1622   1999.8

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    DOI: 10.2337/diabetes.48.8.1615

  • T-786 → C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm Reviewed

    99 ( 22 )   2864 - 2870   1999.6

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    Background - Coronary spasm plays an important role in the pathogenesis of ischemic heart diseases in general. However, the precise mechanism(s) responsible for coronary spasm remains to be elucidated, and we examined the molecular genetics of coronary spasm. Methods and Results - We Searched for the possible mutations in the endothelial nitric oxide synthase (eNOS) gene in patients with coronary spasm. In this study, we demonstrate the existence of 3 linked mutations in the 5'-flanking region of the eNOS gene (T-786 → C, A-922 → G, and T-1468 → A). The incidence of the mutations was significantly greater in patients with coronary spasm than in the control group (P < 0.0001). Multiple logistic regression analysis with forward stepwise selection using the environmental risk factors and the eNOS gene variant revealed that the most predictive independent risk factor for coronary spasm was the mutant allele (P < 0.0001). As assessed by luciferase reporter gene assays, the T-786 → C mutation resulted in a significant reduction in eNOS gene promoter activity (P < 0.05), whereas neither the A- 922 → G nor the T-1468 → A mutation had any affect. Conclusions - Taken together, these findings strongly suggest that the T-786 → C mutation in the eNOS gene reduces the endothelial NO synthesis and predisposes the patients with the mutation to coronary spasm.

    DOI: 10.1161/01.CIR.99.22.2864

  • Vascular endothelial growth factor (VEGF) expression in human coronary atherosclerotic lesions Possible pathophysiological significance of VEGF in progression of atherosclerosis Reviewed

    Mayumi Inoue, Hiroshi Itoh, Makiko Ueda, Takahiko Naruko, Akiko Kojima, Ryushi Komatsu, Kentaro Doi, Yoshihiro Ogawa, Naohisa Tamura, Kazuhiko Takaya, Toshio Igaki, Jun Yamashita, Tae Hwa Chun, Ken Masatsugu, Anton E. Becker, Kazuwa Nakao

    Circulation   98 ( 20 )   2108 - 2116   1998.11

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    DOI: 10.1161/01.CIR.98.20.2108

  • Skeletal overgrowth in transgenic mice that overexpress brain natriuretic peptide Reviewed

    Michio Suda, Yoshihiro Ogawa, Kiyoshi Tanaka, Naohisa Tamura, Akihiro Yasoda, Toshiya Takigawa, Masahiro Uehira, Hirofumi Nishimoto, Hiroshi Itoh, Yoshihiko Saito, Kohei Shiota, Kazuwa Nakao

    Proceedings of the National Academy of Sciences of the United States of America   95 ( 5 )   2337 - 2342   1998.3

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    DOI: 10.1073/pnas.95.5.2337

  • Leptin production by hydatidiform mole Reviewed

    Norimasa Sagawa, Takahide Mori, Hiroaki Masuzaki, Yoshihiro Ogawa, Kazuwa Nakao

    Lancet   350 ( 9090 )   1518 - 1519   1997.11

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    DOI: 10.1016/S0140-6736(05)63940-2

  • Significance of ventricular myocytes and nonmyocytes interaction during cardiocyte hypertrophy Evidence for endothelin-1 as a paracrine hypertrophic factor from cardiac nonmyocytes Reviewed

    Masaki Harada, Hiroshi Itoh, Osamu Nakagawa, Yoshihiro Ogawa, Yoshihiro Miyamoto, Koichiro Kuwahara, Emiko Ogawa, Toshio Igaki, Jun Yamashita, Izuru Masuda, Takaaki Yoshimasa, Issei Tanaka, Yoshihiko Saito, Kazuwa Nakao

    Circulation   96 ( 10 )   3737 - 3744   1997.11

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    DOI: 10.1161/01.CIR.96.10.3737

  • Human leptin receptor gene in obese Japanese subjects Evidence against either obesity-causing mutations or association of sequence variants with obesity Reviewed

    N. Matsuoka, Y. Ogawa, K. Hosoda, J. Matsuda, H. Masuzaki, T. Miyawaki, N. Azuma, K. Natsui, H. Nishimura, Y. Yoshimasa, S. Nishi, D. B. Thompson, K. Nakao

    Diabetologia   40 ( 10 )   1204 - 1210   1997.10

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    DOI: 10.1007/s001250050808

  • Nonadipose tissue production of leptin Leptin as a novel placenta- derived hormone in humans Reviewed

    Hiroaki Masuzaki, Yoshihiro Ogawa, Norimasa Sagawa, Kiminori Hosoda, Tsunekazu Matsumoto, Hiroko Mise, Haruo Nishimura, Yasunao Yoshimasa, Issei Tanaka, Takahide Mori, Kazuwa Nakao

    Nature medicine   3 ( 9 )   1029 - 1033   1997.9

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    DOI: 10.1038/nm0997-1029

  • Nonsense mutation of leptin receptor in the obese spontaneously hypertensive koletsky rat Reviewed

    Kazuhiko Takaya, Yoshihiro Ogawa, Junko Hiraoka, Kiminori Hosoda, Yukio Yamori, Kazuwa Nakao, Richard J. Koletsky

    Nature genetics   14 ( 2 )   130 - 131   1996.1

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    DOI: 10.1038/ng1096-130

  • Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats Reviewed

    Yoshihiro Ogawa, Hiroaki Masuzaki, Naohi Isse, Taku Okazaki, Kiyoshi Mori, Michika Shigemoto, Noriko Satoh, Naohisa Tamura, Kiminori Hosoda, Yasunao Yoshimasa, Hisato Jingami, Teruo Kawada, Kazuwa Nakao

    Journal of Clinical Investigation   96 ( 3 )   1647 - 1652   1995.9

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    DOI: 10.1172/JCI118204

  • Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction Reviewed

    Norio Hama, Hiroshi Itoh, Gotaro Shirakami, Osamu Nakagawa, Shin Ichi Suga, Yoshihiro Ogawa, Izuru Masuda, Kuniaki Nakanishi, Takaaki Yoshimasa, Yukiya Hashimoto, Masayuki Yamaguchi, Ryouhei Hori, Hirofumi Yasue, Kazuwa Nakao

    Circulation   92 ( 6 )   1558 - 1564   1995.9

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    DOI: 10.1161/01.CIR.92.6.1558

  • Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload Reviewed

    Osamu Nakagawa, Yoshihiro Ogawa, Hiroshi Itoh, Shin Ichi Suga, Yasato Komatsu, Ichiro Kishimoto, Kazuyoshi Nishino, Takaaki Yoshimasa, Kazuwa Nakao

    Journal of Clinical Investigation   96 ( 3 )   1280 - 1287   1995.9

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    DOI: 10.1172/JCI118162

  • Molecular cloning of hamster brain and atrial natriuretic peptide cDNAs. Cardiomyopathic hamsters are useful models for brain and atrial natriuretic peptides Reviewed

    N. Tamura, Y. Ogawa, H. Itoh, H. Arai, S. I. Suga, O. Nakagawa, Y. Komatsu, I. Kishimoto, K. Takaya, T. Yoshimasa, S. Shiono, K. Nakao

    Journal of Clinical Investigation   94 ( 3 )   1059 - 1068   1994.9

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    DOI: 10.1172/jci117420

  • Molecular cloning of the complementary DNA and gene that encode mouse brain natriuretic peptide and generation of transgenic mice that overexpress the brain natriuretic peptide gene Reviewed

    Yoshihiro Ogawa, Hiroshi Itoh, Naohisa Tamura, Shin Ichi Suga, Takaaki Yoshimasa, Masahiro Uehira, Saburo Matsuda, Shozo Shiono, Hirofumi Nishimoto, Kazuwa Nakao

    Journal of Clinical Investigation   93 ( 5 )   1911 - 1921   1994.5

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    DOI: 10.1172/JCI117182

  • Lymphocytic Infundibuloneurohypophysitis as a Cause of Central Diabetes Insipidus Reviewed

    Hiroo Imura, Kazuwa Nakao, Akira Shimatsu, Yoshihiro Ogawa, Takehiro Sando, Ichiro Fujisawa, Hirohiko Yamabe

    New England Journal of Medicine   329 ( 10 )   683 - 689   1993.9

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    DOI: 10.1056/NEJM199309023291002

  • Vascular natriuretic peptide Reviewed

    Yasato Komatsu, Kazuwa Nakao, Itoh Hiroshi Itoh, Shin Ichi Suga, Yoshihiro Ogawa, Hiroo Imura

    The Lancet   340 ( 8819 )   1992.9

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    DOI: 10.1016/0140-6736(92)92167-E

  • Endothelial production of C-type natriuretic peptide and its marked augmentation by transforming growth factor-β. Possible existence of 'vascular natriuretic peptide system' Reviewed

    90 ( 3 )   1145 - 1149   1992.9

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    C-type natriuretic peptide (CNP), the third member of the natriuretic peptide family, is thus far known to be distributed mainly in the central nervous system and is considered to act as a neuropeptide, in contrast to atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which act as cardiac hormones. Recently, we and others have demonstrated that the ANP-B receptor, which is selectively activated by CNP, is localized not only in the central nervous system but in peripheral tissues, including blood vessels. This finding has made us speculate regarding the peripheral production of CNP. In the present study, cultured endothelial cells were examined for CNP production by RIA and Northern blot analysis. CNP-like immunoreactivity was detected in the conditioned media of endothelial cells. Northern blot analysis detected CNPmRNA with a size of 1.2 kb. In addition, transforming growth factor (TGF)-β, one of the key growth factors for vascular remodeling, markedly stimulated the expression of CNPmRNA and induced a tremendous increase in CNP secretion. We could also detect CNP transcript in the bovine thoracic aorta using the reverse transcription- polymerase chain reaction method. The present study demonstrates the endothelial production of CNP and suggests that a member of the natriuretic peptide family may act as a local regulator in vascular walls. Since evidence for the pathophysiological importance of the vascular renin-angiotensin system has been accumulating and the natriuretic peptide system is known to be antagonistic to the renin-angiotensin system, the possible existence of 'vascular natriuretic peptide system' may prove to be of physiological and clinical relevance.

    DOI: 10.1172/JCI115933

  • Brain natriuretic peptide as a novel cardiac hormone in humans Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide Reviewed

    M. Mukoyama, K. Nakao, K. Hosoda, S. I. Suga, Y. Saito, Y. Ogawa, G. Shirakami, M. Jougasaki, K. Obata, H. Yasue, Y. Kambayashi, K. Inouye, H. Imura

    Journal of Clinical Investigation   87 ( 4 )   1402 - 1412   1991.4

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    DOI: 10.1172/JCI115146

  • Natriuretic peptides as cardiac hormones in normotensive and spontaneously hypertensive rats The ventricle is a major site of synthesis and secretion of brain natriuretic peptide Reviewed

    Y. Ogawa, K. Nakao, M. Mukoyama, K. Hosoda, G. Shirakami, H. Arai, Y. Saito, S. I. Suga, M. Jougasaki, H. Imura

    Circulation research   69 ( 2 )   491 - 500   1991.1

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    DOI: 10.1161/01.RES.69.2.491

  • Increased Human Brain Natriuretic Peptide in Congestive Heart Failure Reviewed

    Masashi Mukoyama, Kazuwa Nakao, Yoshihiko Saito, Yoshihiro Ogawa, Kiminori Hosoda, Shin Ichi Suga, Gotaro Shirakami, Michihisa Jougasaki, Hiroo Imura

    New England Journal of Medicine   323 ( 11 )   757 - 758   1990.9

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    DOI: 10.1056/NEJM199009133231114

  • Rat brain natriuretic peptide — tissue distribution and molecular form — Reviewed

    126 ( 4 )   2225 - 2227   1990.4

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    Using an antiserum against the ring structure of rat brain natriuretic peptide (rat BNP), we have established a specific radioimmunoassay (RIA) for rat BNP and elucidated its tissue distribution and molecular form. Rat BNP-like immunoreactivity (-LI) was detected in the highest amount in cardiac extracts (574.0 ± 138.8 pmol/g in the atrium and 4.3 ± 1.1 pmol/g in the ventricle). The secretory rate of rat BNP-LI from the perfused whole heart was.50.0 ± 1.9 fmol/min, about 60% of which was maintained even after atrial removal. We also detected rat BNP-LI throughout the spinal cord (134-175 fmol/g), although no detectable amount was present (less than 100 fmol/g) in other tissues including the brain. High performance-gel permeation chromatography and reverse phase-high performance liquid chromatography coupled with the RIA revealed that rat BNP with 45 amino acids is a major storage form as well as a secretory form of rat BNP-LI in the heart. The major component in the spinal cord was also rat BNP. These findings indicate that the tissue distribution and the processing pattern of rat BNP are different from those of atrial natriuretic peptide and porcine BNP, thereby suggesting the presence of complicated diversity of the natriuretic peptide system.

    DOI: 10.1210/endo-126-4-2225

  • Human brain natriuretic peptide, a novel cardiac hormone Reviewed

    Masashi Mukoyama, Kazuwa Nakao, Yoshihiko Saito, Yoshihiro Ogawa, Kiminori Hosoda, Shin Ichi Suga, Gotaro Shirakami, Michihisa Jougasaki, Hiroo Imura

    The Lancet   335 ( 8692 )   801 - 802   1990.3

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    DOI: 10.1016/0140-6736(90)90925-U

  • Single-cell and spatial transcriptomics analysis of human adrenal aging. International journal

    Norifusa Iwahashi, Hironobu Umakoshi, Masamichi Fujita, Tazuru Fukumoto, Tatsuki Ogasawara, Maki Yokomoto-Umakoshi, Hiroki Kaneko, Hiroshi Nakao, Namiko Kawamura, Naohiro Uchida, Yayoi Matsuda, Ryuichi Sakamoto, Masahide Seki, Yutaka Suzuki, Kohta Nakatani, Yoshihiro Izumi, Takeshi Bamba, Yoshinao Oda, Yoshihiro Ogawa

    Molecular metabolism   101954 - 101954   2024.5

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    DOI: 10.1016/j.molmet.2024.101954

  • Clinicopathological significance of microsatellite instability and immune escape mechanism in patients with gastric solid-type poorly differentiated adenocarcinoma.

    Shinya Umekita, Daisuke Kiyozawa, Kenichi Kohashi, Shinichiro Kawatoko, Taisuke Sasaki, Eikichi Ihara, Eiji Oki, Masafumi Nakamura, Yoshihiro Ogawa, Yoshinao Oda

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   2024.3

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    DOI: 10.1007/s10120-024-01474-w

  • The interplay between alterations in esophageal microbiota associated with Th17 immune response and impaired LC20 phosphorylation in achalasia.

    Hiroko Ikeda, Eikichi Ihara, Kosuke Takeya, Koji Mukai, Manabu Onimaru, Kenoki Ouchida, Yoshitaka Hata, Xiaopeng Bai, Yoshimasa Tanaka, Taisuke Sasaki, Fumiyo Saito, Masumi Eto, Jiro Nakayama, Yoshinao Oda, Masafumi Nakamura, Haruhiro Inoue, Yoshihiro Ogawa

    Journal of gastroenterology   2024.3

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    DOI: 10.1007/s00535-024-02088-w

  • Primary aldosteronism patients with previous cardiovascular and cerebrovascular events have high aldosterone responsiveness to ACTH stimulation.

    Eriko Nakano, Kosuke Mukai, Atsunori Fukuhara, Michio Otsuki, Iichiro Shimomura, Takamasa Ichijo, Mika Tsuiki, Norio Wada, Takashi Yoneda, Yoshiyu Takeda, Kenji Oki, Tetsuya Yamada, Yoshihiro Ogawa, Daisuke Yabe, Miki Kakutani, Masakatsu Sone, Takuyuki Katabami, Akiyo Tanabe, Mitsuhide Naruse

    Endocrine journal   2024.3

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    DOI: 10.1507/endocrj.EJ23-0659

  • Improvement of periodontal parameters following intensive diabetes care and supragingival dental prophylaxis in patients with type 2 diabetes: A prospective cohort study. International journal

    Koji Mizutani, Isao Minami, Risako Mikami, Daisuke Kido, Kohei Takeda, Keita Nakagawa, Shu Takemura, Natsumi Saito, Hiromi Kominato, Eri Sakaniwa, Kuniha Konuma, Yuichi Izumi, Yoshihiro Ogawa, Takanori Iwata

    Journal of clinical periodontology   2024.3

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    DOI: 10.1111/jcpe.13958

  • Impact of coronavirus disease 2019 on medical practice in endocrine and metabolic diseases in Japan: a nationwide surveillance study conducted by the Japan Endocrine Society.

    Katsunori Manaka, Sayaka Kato, Ryuichi Sakamoto, Hajime Yamakage, Tsugumi Uema, Shiori Kawai, Megumi Shibata, Izumi Hiratsuka, Sawako Nakachi, Takeshi Onoue, Takefumi Tsuchiya, Michiaki Fukui, Koshi Hashimoto, Atsushi Suzuki, Noriko Makita, Yoshihiro Ogawa, Hiroshi Arima, Noriko Satoh-Asahara, Hiroaki Masuzaki

    Endocrine journal   2024.3

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    DOI: 10.1507/endocrj.EJ23-0671

  • Efficacy and safety of streptozocin-based chemotherapy for gastroenteropancreatic neuroendocrine tumors in Japanese clinical practice. International journal

    Masatoshi Murakami, Nao Fujimori, Yu Takamatsu, Tetsuhide Ito, Kazuhide Matsumoto, Shotaro Kakehashi, Akihisa Ohno, Katsuhito Teramatsu, Keijiro Ueda, Kousei Ishigami, Yoshihiro Ogawa

    Japanese journal of clinical oncology   2024.2

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    DOI: 10.1093/jjco/hyae026

  • Comparison of hemostatic ability between spray coagulation and forced coagulation modes in endoscopic submucosal dissection in patients with early gastric neoplasms: a study protocol for multicenter randomized controlled trial (Spray-G trial). International journal

    Kosuke Maehara, Mitsuru Esaki, Yorinobu Sumida, Daisuke Yamaguchi, Kei Nishioka, Hitoshi Homma, Taisuke Inada, Kazuo Shiotsuki, Shin-Ichiro Fukuda, Hirotada Akiho, Tadahiro Nomura, Yumi Mizuta, Satoshi Ishida, Shun Fujimoto, Shunichiro Kimura, Yuichiro Tanaka, Kaori Hata, Noriko Shiga, Tsutomu Iwasa, Yusuke Kimura, Norimoto Nakamura, Yusuke Suzuki, Yosuke Minoda, Yoshitaka Hata, Haruei Ogino, Koshiro Tagawa, Eikichi Ihara, Yoshihiro Ogawa

    Trials   25 ( 1 )   53 - 53   2024.1

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    DOI: 10.1186/s13063-023-07852-6

  • Two cases of pancreatic neuroendocrine tumors with ectopic ACTH syndrome during their disease course.

    Masatoshi Murakami, Keisuke Hirahata, Nao Fujimori, Takeo Yamamoto, Yoshinao Oda, Shingo Kozono, Keijiro Ueda, Testuhide Ito, Masafumi Nakamura, Yoshihiro Ogawa

    Clinical journal of gastroenterology   2024.1

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    DOI: 10.1007/s12328-023-01908-5

  • Three-point traction method for endoscopic submucosal dissection using clip-with-thread and clip-with-silicon bands for large early gastric neoplasms. International journal

    Ryohei Maruoka, Mitsuru Esaki, Yosuke Minoda, Noriko Tokunaga, Kazuhiro Haraguchi, Eikichi Ihara, Yoshihiro Ogawa

    Endoscopy international open   12 ( 1 )   E57-E58   2024.1

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    DOI: 10.1055/a-2219-8130

  • Gastric endoscopic submucosal dissection assisted by intralesional cross-traction using silicone bands. International journal

    Yusuke Suzuki, Mitsuru Esaki, Taisuke Inada, Yosuke Minoda, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa

    Endoscopy   55 ( S 01 )   E324-E325   2023.12

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    DOI: 10.1055/a-1982-3875

  • Wide-scope targeted analysis of bioactive lipids in human plasma by LC/MS/MS International journal

    Kohta Nakatani, Yoshihiro Izumi, Hironobu Umakoshi, Maki Yokomoto-Umakoshi, Tomoko Nakaji, Hiroki Kaneko, Hiroshi Nakao, Yoshihiro Ogawa, Kazutaka Ikeda, Takeshi Bamba

    Journal of Lipid Research   65 ( 1 )   100492 - 100492   2023.12

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    DOI: 10.1016/j.jlr.2023.100492

  • Two-point fixed pulley-traction method in endoscopic submucosal dissection for early gastric neoplasm. International journal

    Tsubasa Takeuchi, Mitsuru Esaki, Yosuke Minoda, Yoshitaka Hata, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa

    Endoscopy   55 ( S 01 )   E1087-E1088   2023.12

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    DOI: 10.1055/a-2173-8010

  • Gastric endoscopic submucosal dissection assisted by intralesional cross-traction using silicone bands. International journal

    Yusuke Suzuki, Mitsuru Esaki, Taisuke Inada, Yosuke Minoda, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa

    Endoscopy   55 ( S 01 )   E324-E325   2023.12

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    DOI: 10.1055/a-1982-3875

  • Development of a new endoscopy system to visualize bilirubin for the diagnosis of duodenogastroesophageal reflux. International journal

    Masafumi Wada, Yosuke Minoda, Eikichi Ihara, Hirotaka Tsuru, Yoshitaka Hata, Shuzaburo Nagatomo, Mitsuru Esaki, Xiaopeng Bai, Yoshimasa Tanaka, Takatoshi Chinen, Haruei Ogino, Yoshihiro Ogawa

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   2023.12

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    DOI: 10.1111/den.14749

  • Dectin-2 Deficiency Promotes Pro-inflammatory Cytokine Release from Macrophages and Impairs Insulin Secretion. International journal

    Masamichi Fujita, Takashi Miyazawa, Keiichiro Uchida, Naohiro Uchida, Shojiro Haji, Seiichi Yano, Norifusa Iwahashi, Tomomi Hatayama, Shunsuke Katsuhara, Shintaro Nakamura, Yukina Takeichi, Maki Yokomoto-Umakoshi, Yasutaka Miyachi, Ryuichi Sakamoto, Yoichiro Iwakura, Yoshihiro Ogawa

    Endocrinology   165 ( 1 )   2023.12

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    DOI: 10.1210/endocr/bqad181

  • Acute kidney injury is an unfavorable prognostic factor in acute liver failure and is associated with tumor necrosis factor-alpha. International journal

    Koji Imoto, Masatake Tanaka, Takeshi Goya, Yuki Azuma, Tomonobu Hioki, Tomomi Aoyagi, Motoi Takahashi, Miho Kurokawa, Masaki Kato, Motoyuki Kohjima, Yoshihiro Ogawa

    Medicine   102 ( 45 )   e35931   2023.11

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    DOI: 10.1097/MD.0000000000035931

  • Melanocortin-4 receptor in macrophages attenuated angiotensin II-induced abdominal aortic aneurysm in mice International journal

    Kentaro Mori, Hideyuki Okuma, Suguru Nakamura, Hiroyuki Uchinuma, Shigeaki Kaga, Hiroyuki Nakajima, Yoshihiro Ogawa, Kyoichiro Tsuchiya

    Scientific Reports   13 ( 1 )   19768 - 19768   2023.11

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    DOI: 10.1038/s41598-023-46831-4

  • Improved endurance capacity of diabetic mice during SGLT2 inhibition: Role of AICARP, an AMPK activator in the soleus. International journal

    Shintaro Nakamura, Yasutaka Miyachi, Akihito Shinjo, Hisashi Yokomizo, Masatomo Takahashi, Kohta Nakatani, Yoshihiro Izumi, Hiroko Otsuka, Naoichi Sato, Ryuichi Sakamoto, Takashi Miyazawa, Takeshi Bamba, Yoshihiro Ogawa

    Journal of cachexia, sarcopenia and muscle   14 ( 6 )   2866 - 2881   2023.11

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    DOI: 10.1002/jcsm.13350

  • Loss of KDM6B epigenetically confers resistance to lipotoxicity in nonalcoholic fatty liver disease-related HCC. International journal

    Megumi Hatano, Yoshimitsu Akiyama, Shu Shimada, Kohei Yagi, Keiichi Akahoshi, Michiko Itoh, Minoru Tanabe, Yoshihiro Ogawa, Shinji Tanaka

    Hepatology communications   7 ( 10 )   2023.10

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    DOI: 10.1097/HC9.0000000000000277

  • Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models. International journal

    Toshiya Matsukawa, Takashi Yagi, Tohru Uchida, Mashito Sakai, Masaru Mitsushima, Takao Naganuma, Hiroyuki Yano, Yuka Inaba, Hiroshi Inoue, Keisuke Yanagida, Masaaki Uematsu, Kazuki Nakao, Harumi Nakao, Atsu Aiba, Yoji Nagashima, Tetsuya Kubota, Naoto Kubota, Yoshihiko Izumida, Naoya Yahagi, Hiroyuki Unoki-Kubota, Yasushi Kaburagi, Shun-Ichiro Asahara, Yoshiaki Kido, Hideo Shindou, Michiko Itoh, Yoshihiro Ogawa, Shiro Minami, Yasuo Terauchi, Kazuyuki Tobe, Kohjiro Ueki, Masato Kasuga, Michihiro Matsumoto

    JCI insight   8 ( 17 )   2023.9

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    DOI: 10.1172/jci.insight.161282

  • Evaluating the efficacy and safety of acotiamide in patients with esophagogastric junction outflow obstruction: study protocol for an investigator-initiated, multi-center, randomized, double-blind, placebo-controlled phase II trial. International journal

    Mitsuru Esaki, Eikichi Ihara, Noriaki Manabe, Noriyuki Kawami, Katsuhiko Iwakiri, Junichi Akiyama, Shiko Kuribayashi, Toshio Uraoka, Haruei Ogino, Takatoshi Chinen, Akiko Misumi, Hiroko Watanabe, Maya Suzuki, Junji Kishimoto, Yoshihiro Ogawa

    Trials   24 ( 1 )   459 - 459   2023.7

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    Language:English  

    DOI: 10.1186/s13063-023-07468-w

  • Clinicopathologic Features of Adult-onset Still's Disease Complicated by Severe Liver Injury.

    Miho Kurokawa, Tomonobu Hioki, Tomomi Aoyagi, Motoi Takahashi, Koji Imoto, Takeshi Goya, Masatake Tanaka, Motoyuki Kohjima, Yoshihiro Ogawa

    Internal medicine (Tokyo, Japan)   2023.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.2043-23

  • Machine learning-based model for prediction and feature analysis of recurrence in pancreatic neuroendocrine tumors G1/G2.

    Masatoshi Murakami, Nao Fujimori, Kohei Nakata, Masafumi Nakamura, Shinichi Hashimoto, Hiroshi Kurahara, Kazuyoshi Nishihara, Toshiya Abe, Shunpei Hashigo, Naotaka Kugiyama, Eisuke Ozawa, Kazuhisa Okamoto, Yusuke Ishida, Keiichi Okano, Ryo Takaki, Yutaka Shimamatsu, Tetsuhide Ito, Masami Miki, Noriko Oza, Daisuke Yamaguchi, Hirofumi Yamamoto, Hironobu Takedomi, Ken Kawabe, Tetsuro Akashi, Koichi Miyahara, Jiro Ohuchida, Yasuhiro Ogura, Yohei Nakashima, Toshiharu Ueki, Kousei Ishigami, Hironobu Umakoshi, Keijiro Ueda, Takamasa Oono, Yoshihiro Ogawa

    Journal of gastroenterology   58 ( 6 )   586 - 597   2023.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00535-023-01987-8

  • Do multiple types of confirmatory tests improve performance in predicting subtypes of primary aldosteronism? International journal

    Hiroki Kaneko, Hironobu Umakoshi, Tazuru Fukumoto, Norio Wada, Takamasa Ichijo, Shohei Sakamoto, Tetsuhiro Watanabe, Yuki Ishihara, Tetsuya Tagami, Masatoshi Ogata, Norifusa Iwahashi, Maki Yokomoto-Umakoshi, Yayoi Matsuda, Ryuichi Sakamoto, Yoshihiro Ogawa

    Clinical endocrinology   98 ( 4 )   473 - 480   2023.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cen.14854

  • Wide scope analysis of bioactive lipids, including steroids, bile acids, and polyunsaturated fatty acid metabolites, in human plasma by LC/MS/MS

    Kohta Nakatani, Yoshihiro Izumi, Hironobu Umakoshi, Maki Yokomoto-Umakoshi, Tomoko Nakaji, Hiroki Kaneko, Hiroshi Nakao, Yoshihiro Ogawa, Kazutaka Ikeda, Takeshi Bamba

    2023.4

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    DOI: 10.1101/2023.04.13.536679

  • Endothelial function testing before conditioning therapy is useful for predicting transplant-related complications after allogeneic hematopoietic cell transplantation.

    Shojiro Haji, Motoaki Shiratsuchi, Akiko Takamatsu, Mariko Tsuda, Hiroki Muta, Toru Masuda, Yasuhiro Nakashima, Yoshihiro Ogawa

    International journal of hematology   117 ( 3 )   438 - 445   2023.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12185-022-03498-3

  • Transcatheter arterial steroid injection therapy improves the prognosis of patients with acute liver failure. International journal

    Akifumi Kuwano, Tasuku Okui, Motoyuki Kohjima, Miho Kurokawa, Takeshi Goya, Masatake Tanaka, Tomomi Aoyagi, Motoi Takahashi, Koji Imoto, Shigeki Tashiro, Hideo Suzuki, Nobuhiro Fujita, Yasuhiro Ushijima, Kousei Ishigami, Shoji Tokunaga, Masaki Kato, Yoshihiro Ogawa

    Medicine   102 ( 10 )   e33090   2023.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/MD.0000000000033090

  • Resistin G-A haplotype at SNP-420/-358 is associated with the latent sarcopenic obesity index in the toon genome study.

    Yosuke Ikeda, Ryoichi Kawamura, Yasunori Takata, Yasuharu Tabara, Koutatsu Maruyama, Misaki Takakado, Toshimi Hadate, Jun Ohashi, Isao Saito, Yoshihiro Ogawa, Haruhiko Osawa

    Journal of diabetes investigation   14 ( 5 )   686 - 694   2023.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jdi.13998

  • A hyperaldosteronism subtypes predictive model using ensemble learning. International journal

    Shigehiro Karashima, Masaki Kawakami, Hidetaka Nambo, Mitsuhiro Kometani, Isao Kurihara, Takamasa Ichijo, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Kenji Oki, Yoshihiro Ogawa, Ryuji Okamoto, Kouichi Tamura, Nobuya Inagaki, Takanobu Yoshimoto, Hiroki Kobayashi, Miki Kakutani, Megumi Fujita, Shoichiro Izawa, Tetsuya Suwa, Kohei Kamemura, Masanobu Yamada, Akiyo Tanabe, Mitsuhide Naruse, Takashi Yoneda

    Scientific reports   13 ( 1 )   3043 - 3043   2023.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-023-29653-2

  • Impact of a change to a novel chemiluminescent immunoassay for measuring plasma aldosterone on the diagnosis of primary aldosteronism.

    Hiroki Kobayashi, Yoshihiro Nakamura, Masanori Abe, Akiyo Tanabe, Masakatsu Sone, Takuyuki Katabami, Isao Kurihara, Takamasa Ichijo, Mika Tsuiki, Shoichiro Izawa, Norio Wada, Takashi Yoneda, Katsutoshi Takahashi, Kouichi Tamura, Yoshihiro Ogawa, Nobuya Inagaki, Koichi Yamamoto, Hiromi Rakugi, Mitsuhide Naruse

    Endocrine journal   70 ( 5 )   489 - 500   2023.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1507/endocrj.EJ22-0585

  • Coexistence of bone and vascular disturbances in patients with endogenous glucocorticoid excess. International journal

    Chieko Yano, Maki Yokomoto-Umakoshi, Masamichi Fujita, Hironobu Umakoshi, Seiichi Yano, Norifusa Iwahashi, Shunsuke Katsuhara, Hiroki Kaneko, Masatoshi Ogata, Tazuru Fukumoto, Eriko Terada, Yayoi Matsuda, Ryuichi Sakamoto, Yoshihiro Ogawa

    Bone reports   17   101610 - 101610   2022.12

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    DOI: 10.1016/j.bonr.2022.101610

  • Incidence and appropriate management of drug-induced interstitial lung disease in Japanese patients with unresectable pancreatic cancer: A multicenter retrospective study. International journal

    Tsukasa Miyagahara, Nao Fujimori, Keijiro Ueda, Yu Takamatsu, Kazuhide Matsumoto, Katsuhito Teramatsu, Takehiro Takaoka, Yuta Suehiro, Yuzo Shimokawa, Kaoru Omori, Yusuke Niina, Yuichi Tachibana, Tetsuro Akashi, Takamasa Oono, Yoshihiro Ogawa

    Asia-Pacific journal of clinical oncology   19 ( 4 )   533 - 541   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ajco.13903

  • Auxiliary diagnosis of subepithelial lesions by impedance measurement during endoscopic ultrasound-guided fine-needle biopsy. International journal

    Yosuke Minoda, Mitsuru Esaki, Eikichi Ihara, Shuzaburo Nagatomo, Kei Nishioka, Nao Fujimori, Haruei Ogino, Xiaopeng Bai, Yoshimasa Tanaka, Takatoshi Chinen, Qingjiang Hu, Mitsuhiko Ota, Shinya Umekita, Hidetaka Yamamoto, Yoshihiro Ogawa

    Gastrointestinal endoscopy   97 ( 5 )   977 - 984   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.gie.2022.11.022

  • Hybrid- and conventional endoscopic submucosal dissection for early gastric neoplasms: a multi-center randomized controlled trial. International journal

    Mitsuru Esaki, Eikichi Ihara, Yorinobu Sumida, Hiroyuki Fujii, Shunsuke Takahashi, Kazuhiro Haraguchi, Tsutomu Iwasa, Shinichi Somada, Yosuke Minoda, Haruei Ogino, Koshiro Tagawa, Yoshihiro Ogawa

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association   21 ( 7 )   1810 - 1818   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cgh.2022.10.030

  • Circulating CD8+CD122+ T cells as a prognostic indicator of pancreatic cancer. International journal

    Katsuhito Teramatsu, Takamasa Oono, Koki Oyama, Nao Fujimori, Masatoshi Murakami, Sho Yasumori, Akihisa Ohno, Kazuhide Matsumoto, Ayumu Takeno, Kohei Nakata, Masafumi Nakamura, Yoshihiro Ogawa

    BMC cancer   22 ( 1 )   1134 - 1134   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12885-022-10207-0

  • Bile peritonitis after placement of a metallic stent in endoscopic ultrasound-guided hepaticogastrostomy: A pitfall and the rescue technique. International journal

    Akihisa Ohno, Nao Fujimori, Toshiya Abe, Masafumi Nakamura, Yoshihiro Ogawa

    Endoscopy   55 ( S 01 )   E94-E95   2022.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/a-1937-9781

  • Bile peritonitis after placement of a metallic stent in endoscopic ultrasound-guided hepaticogastrostomy: A pitfall and the rescue technique. International journal

    Akihisa Ohno, Nao Fujimori, Toshiya Abe, Masafumi Nakamura, Yoshihiro Ogawa

    Endoscopy   55 ( S 01 )   E94-E95   2022.10

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    Language:English  

    DOI: 10.1055/a-1937-9781

  • The feasibility of percutaneous transhepatic gallbladder aspiration for acute cholecystitis after self-expandable metallic stent placement for malignant biliary obstruction: a 10-year retrospective analysis in a single center. International journal

    Akihisa Ohno, Nao Fujimori, Toyoma Kaku, Masayuki Hijioka, Ken Kawabe, Naohiko Harada, Makoto Nakamuta, Takamasa Oono, Yoshihiro Ogawa

    Clinical endoscopy   55 ( 6 )   784 - 792   2022.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5946/ce.2021.244

  • Efficacy of ultrasound endoscopy with artificial intelligence for the differential diagnosis of non-gastric gastrointestinal stromal tumors. International journal

    Yosuke Minoda, Eikichi Ihara, Nao Fujimori, Shuzaburo Nagatomo, Mitsuru Esaki, Yoshitaka Hata, Xiaopeng Bai, Yoshimasa Tanaka, Haruei Ogino, Takatoshi Chinen, Qingjiang Hu, Eiji Oki, Hidetaka Yamamoto, Yoshihiro Ogawa

    Scientific reports   12 ( 1 )   16640 - 16640   2022.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-022-20863-8

  • Association of cardiovascular disease risk and changes in renin levels by mineralocorticoid receptor antagonists in patients with primary aldosteronism. International journal

    Motoko Nomura, Isao Kurihara, Hiroshi Itoh, Takamasa Ichijo, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Takashi Yoneda, Masakatsu Sone, Kenji Oki, Tetsuya Yamada, Hiroki Kobayashi, Kouichi Tamura, Yoshihiro Ogawa, Nobuya Inagaki, Koichi Yamamoto, Michio Otsuki, Daisuke Yabe, Shoichiro Izawa, Yutaka Takahashi, Tomoko Suzuki, Akihiro Yasoda, Akiyo Tanabe, Mitsuhide Naruse

    Hypertension research : official journal of the Japanese Society of Hypertension   45 ( 9 )   1476 - 1485   2022.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41440-022-00960-x

  • Associated factors and effects of comorbid atrial fibrillation in hypertensive patients due to primary aldosteronism.

    Sakaguchi S, Ryuji Okamoto, Inoue C, Masaharu Akao, Kamemura K, Kurihara I, Takeda Y, Ohno Y, Inagaki N, Hiromi Rakugi, TAKUYUKI KATABAMI, Tsuiki M, AKIYO TANABE, Tamura K, Fujita S, Yano Y, Dohi K, JRAS investigators, Mitsuhide Naruse

    Journal of human hypertension   2022.9

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    DOI: 10.1038/s41371-022-00753-2

  • Effect of Intraprocedural Cortisol Measurement on ACTH-stimulated Adrenal Vein Sampling in Primary Aldosteronism. International journal

    Mitsuhiro Kometani, Takashi Yoneda, Shigehiro Karashima, Yoshiyu Takeda, Mika Tsuiki, Akihiro Yasoda, Isao Kurihara, Norio Wada, Takuyuki Katabami, Masakatsu Sone, Takamasa Ichijo, Kouichi Tamura, Yoshihiro Ogawa, Hiroki Kobayashi, Shintaro Okamura, Nobuya Inagaki, Junji Kawashima, Megumi Fujita, Kenji Oki, Yuichi Matsuda, Akiyo Tanabe, Mitsuhide Naruse

    Journal of the Endocrine Society   6 ( 9 )   bvac104   2022.9

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    DOI: 10.1210/jendso/bvac104

  • Circulating endothelial cells and endothelial progenitor cells as potential predictors of acute GVHD after allogeneic hematopoietic stem cell transplantation. International journal

    Akiko Takamatsu, Yasuhiro Nakashima, Shojiro Haji, Mariko Tsuda, Toru Masuda, Daisaku Kimura, Motoaki Shiratsuchi, Yoshihiro Ogawa

    European journal of haematology   109 ( 2 )   146 - 153   2022.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ejh.13781

  • Elevated Pancreatic Enzymes Associated with Acute Liver Injury Were Mediated by Tumor Necrosis Factor-Alpha Signaling

    Takeshi Goya, Miho Kurokawa, Tomonobu Hioki, Tomomi Aoyagi, Motoi Takahashi, Koji Imoto, Shigeki Tashiro, Hideo Suzuki, Masatake Tanaka, Masaki Kato, Motoyuki Kohjima, Yoshihiro Ogawa

    Hepatitis Monthly   22 ( 1 )   2022.8

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    DOI: 10.5812/hepatmon-128106

  • Treatment Effect and Safety of Nanoliposomal Irinotecan with Fluorouracil and Folinic Acid after Gemcitabine-Based Therapy in Patients with Advanced Pancreatic Cancer: A Multicenter, Prospective Observational Study. International journal

    Masami Miki, Nao Fujimori, Keijiro Ueda, Lingaku Lee, Masatoshi Murakami, Yu Takamatsu, Yuzo Shimokawa, Yusuke Niina, Takamasa Oono, Terumasa Hisano, Masayuki Furukawa, Yoshihiro Ogawa

    Journal of clinical medicine   11 ( 17 )   2022.8

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    DOI: 10.3390/jcm11175084

  • Rapid decrease in eGFR with concomitant use of tyrosine kinase inhibitors and renin-aldosterone-angiotensin system inhibitors in patients with chronic myelogenous leukemia.

    Mariko Tsuda, Akie Hirata, Shoji Tokunaga, Toru Masuda, Shojiro Haji, Daisaku Kimura, Chinatsu Nojiri, Yasuhiro Nakashima, Motoaki Shiratsuchi, Koji Kato, Toshihiro Miyamoto, Koichi Akashi, Naoki Nakashima, Yoshihiro Ogawa

    International journal of hematology   116 ( 6 )   863 - 870   2022.8

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    DOI: 10.1007/s12185-022-03433-6

  • Improved esophagography screening for esophageal motility disorders using wave appearance and supra-junctional ballooning.

    Yoshitaka Hata, Eikichi Ihara, Masafumi Wada, Hirotaka Tsuru, Kazumasa Muta, Yosuke Minoda, Xiaopeng Bai, Mitsuru Esaki, Yoshimasa Tanaka, Takatoshi Chinen, Haruei Ogino, Ryuichi Sakamoto, Yoshihiro Ogawa

    Journal of gastroenterology   57 ( 11 )   838 - 847   2022.8

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    DOI: 10.1007/s00535-022-01913-4

  • Genetic Analysis of Pheochromocytoma and Paraganglioma Complicating Cyanotic Congenital Heart Disease. International journal

    Tatsuki Ogasawara, Yoichi Fujii, Nobuyuki Kakiuchi, Yusuke Shiozawa, Ryuichi Sakamoto, Yoshihiro Ogawa, Katsuki Ootani, Etsuro Ito, Tomoaki Tanaka, Kenichiro Watanabe, Yusaku Yoshida, Noriko Kimura, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seishi Ogawa

    The Journal of clinical endocrinology and metabolism   107 ( 9 )   2545 - 2555   2022.8

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    DOI: 10.1210/clinem/dgac362

  • Elevated Pancreatic Enzymes Associated with Acute Liver Injury Were Mediated by Tumor Necrosis Factor-Alpha Signaling

    Takeshi Goya, Miho Kurokawa, Tomonobu Hioki, Tomomi Aoyagi, Motoi Takahashi, Koji Imoto, Shigeki Tashiro, Hideo Suzuki, Masatake Tanaka, Masaki Kato, Motoyuki Kohjima, Yoshihiro Ogawa

    Hepatitis Monthly   22 ( 1 )   2022.8

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    DOI: 10.5812/hepatmon-128106

  • Determination of Region-Specific Roles of the M3 Muscarinic Acetylcholine Receptor in Gastrointestinal Motility. International journal

    Yoko Igarashi-Hisayoshi, Eikichi Ihara, Xiaopeng Bai, Chika Higashi, Hiroko Ikeda, Yoshimasa Tanaka, Mayumi Hirano, Haruei Ogino, Takatoshi Chinen, Yasushi Taguchi, Yoshihiro Ogawa

    Digestive diseases and sciences   68 ( 2 )   439 - 450   2022.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10620-022-07637-y

  • Brain fractalkine-CX3CR1 signalling is anti-obesity system as anorexigenic and anti-inflammatory actions in diet-induced obese mice. International journal

    Namiko Kawamura, Goro Katsuura, Nobuko Yamada-Goto, Riho Nakama, Yuki Kambe, Atsuro Miyata, Tomoyuki Furuyashiki, Shuh Narumiya, Yoshihiro Ogawa, Akio Inui

    Scientific reports   12 ( 1 )   12604 - 12604   2022.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-022-16944-3

  • Negligible procedure-related dissemination risk of mucosal incision-assisted biopsy for gastrointestinal stromal tumors versus endoscopic ultrasound-guided fine-needle aspiration/biopsy. International journal

    Yosuke Minoda, Eikichi Ihara, Soichi Itaba, Yorinobu Sumida, Kazuhiro Haraguchi, Akira Aso, Takahiro Mizutani, Takashi Osoegawa, Mitsuru Esaki, Shuzaburo Nagatomo, Kei Nishioka, Kazumasa Muta, Xiaopeng Bai, Haruei Ogino, Nao Fujimori, Daisuke Tsurumaru, Kenoki Ohuchida, Hu Qingjiang, Eiji Oki, Hidetaka Yamamoto, Yoshihiro Ogawa

    Surgical endoscopy   37 ( 1 )   101 - 108   2022.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00464-022-09419-z

  • Direct Conversion of Human Endothelial Cells Into Liver Cancer-Forming Cells Using Nonintegrative Episomal Vectors. International journal

    Takeshi Goya, Kenichi Horisawa, Miyako Udono, Yasuyuki Ohkawa, Yoshihiro Ogawa, Sayaka Sekiya, Atsushi Suzuki

    Hepatology communications   6 ( 7 )   1725 - 1740   2022.7

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    DOI: 10.1002/hep4.1911

  • Feasibility and Efficacy of Endoscopic Ultrasound-Guided Hepaticogastrostomy Without Dilation: A Propensity Score Matching Analysis. International journal

    Akihisa Ohno, Nao Fujimori, Toyoma Kaku, Yu Takamatsu, Kazuhide Matsumoto, Masatoshi Murakami, Katsuhito Teramatsu, Ayumu Takeno, Masayuki Hijioka, Ken Kawabe, Naohiko Harada, Makoto Nakamuta, Akira Aso, Takamasa Oono, Yoshihiro Ogawa

    Digestive diseases and sciences   67 ( 12 )   5676 - 5684   2022.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10620-022-07555-z

  • Innovative endoscopic submucosal dissection for early gastric neoplasm using intralesional traction and snaring techniques. International journal

    Yoshihisa Shoguchi, Mitsuru Esaki, Yosuke Minoda, Xiaopeng Bai, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa

    Endoscopy   54 ( S 02 )   E865-E866   2022.6

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    Language:English  

    DOI: 10.1055/a-1841-5907

  • The Glasgow Prognostic Score and stricture site can predict prognosis after endoscopic duodenal stent placement for malignant gastric outlet obstruction. International journal

    Yu Takamatsu, Nao Fujimori, Tsukasa Miyagahara, Yuta Suehiro, Toyoma Kaku, Ken Kawabe, Akihisa Ohno, Kazuhide Matsumoto, Masatoshi Murakami, Katsuhito Teramatsu, Ayumu Takeno, Takamasa Oono, Yoshihiro Ogawa

    Scientific reports   12 ( 1 )   9746 - 9746   2022.6

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    DOI: 10.1038/s41598-022-13209-x

  • Over-the-catheter endoscope replacement for stenting in patients with inaccessible malignant colonic obstruction with coexisting peritoneal carcinomatosis. International journal

    Yoichiro Iboshi, Yorinobu Sumida, Eikichi Ihara, Hiroyuki Fujii, Naohiko Harada, Makoto Nakamuta, Yoshihiro Ogawa

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   34 ( 7 )   1481 - 1490   2022.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/den.14385

  • Innovative endoscopic submucosal dissection for early gastric neoplasm using intralesional traction and snaring techniques. International journal

    Yoshihisa Shoguchi, Mitsuru Esaki, Yosuke Minoda, Xiaopeng Bai, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa

    Endoscopy   54 ( S 02 )   E865-E866   2022.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/a-1841-5907

  • A clinical analysis on functioning pancreatic neuroendocrine tumors (focusing on VIPomas): a single-center experience.

    Masatoshi Murakami, Nao Fujimori, Kazuhide Matsumoto, Akihisa Ohno, Katsuhito Teramatsu, Yu Takamatsu, Ayumu Takeno, Keijiro Ueda, Takamasa Oono, Tetsuhide Ito, Yoshihiro Ogawa

    Endocrine journal   69 ( 10 )   1201 - 1209   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1507/endocrj.EJ22-0111

  • What is the best modality for diagnosing pancreatic cancer? International journal

    Nao Fujimori, Yosuke Minoda, Yoshihiro Ogawa

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   34 ( 4 )   744 - 746   2022.5

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    Language:English  

    DOI: 10.1111/den.14283

  • Tumor progression by epithelial-mesenchymal transition in ARID1A- and SMARCA4-aberrant solid-type poorly differentiated gastric adenocarcinoma. International journal

    Taisuke Sasaki, Kenichi Kohashi, Shinichiro Kawatoko, Eikichi Ihara, Eiji Oki, Masafumi Nakamura, Yoshihiro Ogawa, Yoshinao Oda

    Virchows Archiv : an international journal of pathology   480 ( 5 )   1063 - 1075   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00428-021-03261-9

  • Ampullary Neuroendocrine Neoplasm: Clinicopathological Characteristics and Novel Endoscopic Entity. International journal

    Kazuhide Matsumoto, Nao Fujimori, Yoshitaka Hata, Yosuke Minoda, Masatoshi Murakami, Katsuhito Teramatsu, Yu Takamatsu, Ayumu Takeno, Takamasa Oono, Eikichi Ihara, Kohei Nakata, Masafumi Nakamura, Takeo Yamamoto, Yutaka Koga, Yoshinao Oda, Tetsuhide Ito, Yoshihiro Ogawa

    Digestive diseases (Basel, Switzerland)   41 ( 2 )   316 - 324   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000525013

  • An adult case of congenital duodenal diaphragm that was successfully treated by endoscopic resection using a grasping-type scissor forceps. International journal

    Shin-Ichiro Fukuda, Kaoru Ichida, Yusuke Kitagawa, Kayoko Nakano, Chaen Tomohito, Daisuke Yoshimura, Toshiaki Ochiai, Eikichi Ihara, Yoshihiro Ogawa

    DEN open   2 ( 1 )   e93   2022.4

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    Language:English  

    DOI: 10.1002/deo2.93

  • Primary aldosteronism with mild autonomous cortisol secretion increases renal complication risk. International journal

    Takuyuki Katabami, Ren Matsuba, Hiroki Kobayashi, Tomoko Nakagawa, Isao Kurihara, Takamasa Ichijo, Mika Tsuiki, Norio Wada, Yoshihiro Ogawa, Masakatsu Sone, Nobuya Inagaki, Takanobu Yoshimoto, Katsutoshi Takahashi, Koichi Yamamoto, Shoichiro Izawa, Miki Kakutani, Akiyo Tanabe, Mitsuhide Naruse

    European journal of endocrinology   186 ( 6 )   645 - 655   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1530/EJE-21-1131

  • Machine learning-based models for predicting clinical outcomes after surgery in unilateral primary aldosteronism. International journal

    Hiroki Kaneko, Hironobu Umakoshi, Masatoshi Ogata, Norio Wada, Takamasa Ichijo, Shohei Sakamoto, Tetsuhiro Watanabe, Yuki Ishihara, Tetsuya Tagami, Norifusa Iwahashi, Tazuru Fukumoto, Eriko Terada, Shunsuke Katsuhara, Maki Yokomoto-Umakoshi, Yayoi Matsuda, Ryuichi Sakamoto, Yoshihiro Ogawa

    Scientific reports   12 ( 1 )   5781 - 5781   2022.4

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    DOI: 10.1038/s41598-022-09706-8

  • Japan Endocrine Society clinical practice guideline for the diagnosis and management of primary aldosteronism 2021.

    Mitsuhide Naruse, Takuyuki Katabami, Hirotaka Shibata, Masakatsu Sone, Katsutoshi Takahashi, Akiyo Tanabe, Shoichiro Izawa, Takamasa Ichijo, Michio Otsuki, Masao Omura, Yoshihiro Ogawa, Yutaka Oki, Isao Kurihara, Hiroki Kobayashi, Ryuichi Sakamoto, Fumitoshi Satoh, Yoshiyu Takeda, Tomoaki Tanaka, Kouichi Tamura, Mika Tsuiki, Shigeatsu Hashimoto, Tomonobu Hasegawa, Takanobu Yoshimoto, Takashi Yoneda, Koichi Yamamoto, Hiromi Rakugi, Norio Wada, Aya Saiki, Youichi Ohno, Tatsuya Haze

    Endocrine journal   69 ( 4 )   327 - 359   2022.4

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    DOI: 10.1507/endocrj.EJ21-0508

  • Comparisons of outcomes between ProKnife injection endoscopic submucosal dissection and conventional endoscopic submucosal dissection for large gastric lesions in ex vivo porcine model study: A randomized controlled trial. International journal

    Mitsuru Esaki, Eikichi Ihara, Misato Esaki, Kei Nishioka, Yusuke Kimura, Yoshitaka Hata, Hirotaka Tsuru, Masafumi Wada, Yosuke Minoda, Xiaopeng Bai, Yoshihisa Shoguchi, Takayuki Nasu, Shuzaburo Nagatomo, Kazumasa Muta, Haruei Ogino, Yoshihiro Ogawa

    DEN open   2 ( 1 )   e91   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/deo2.91

  • Corticosteroid suppresses urea-cycle-related gene expressions in ornithine transcarbamylase deficiency. International journal

    Koji Imoto, Masatake Tanaka, Takeshi Goya, Tomomi Aoyagi, Motoi Takahashi, Miho Kurokawa, Shigeki Tashiro, Masaki Kato, Motoyuki Kohjima, Yoshihiro Ogawa

    BMC gastroenterology   22 ( 1 )   144 - 144   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12876-022-02213-0

  • Impact of Cortisol on Reduction in Muscle Strength and Mass: A Mendelian Randomization Study. International journal

    Shunsuke Katsuhara, Maki Yokomoto-Umakoshi, Hironobu Umakoshi, Yayoi Matsuda, Norifusa Iwahashi, Hiroki Kaneko, Masatoshi Ogata, Tazuru Fukumoto, Eriko Terada, Ryuichi Sakamoto, Yoshihiro Ogawa

    The Journal of clinical endocrinology and metabolism   107 ( 4 )   e1477-e1487   2022.3

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    DOI: 10.1210/clinem/dgab862

  • HNF1A Mutations and Beta Cell Dysfunction in Diabetes. International journal

    Yasutaka Miyachi, Takashi Miyazawa, Yoshihiro Ogawa

    International journal of molecular sciences   23 ( 6 )   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms23063222

  • Association between cortisol and left ventricular diastolic dysfunction in patients with diabetes mellitus.

    Rikako Sagara, Tomoaki Inoue, Noriyuki Sonoda, Chieko Yano, Misato Motoya, Hironobu Umakoshi, Ryuichi Sakamoto, Yoshihiro Ogawa

    Journal of diabetes investigation   13 ( 2 )   344 - 350   2022.2

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    DOI: 10.1111/jdi.13653

  • FOXO1 cooperates with C/EBPδ and ATF4 to regulate skeletal muscle atrophy transcriptional program during fasting. International journal

    36 ( 2 )   e22152   2022.2

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    Catabolic conditions, such as starvation, inactivity, and cancer cachexia, induce Forkhead box O (FOXO) transcription factor(s) expression and severe muscle atrophy via the induction of ubiquitin-proteasome system-mediated muscle proteolysis, resulting in frailty and poor quality of life. Although FOXOs are clearly essential for the induction of muscle atrophy, it is unclear whether there are other factors involved in the FOXO-mediated transcriptional regulation. As such, we identified FOXO-CCAAT/enhancer-binding protein δ (C/EBPδ) signaling pathway as a novel proteolytic pathway. By comparing the gene expression profiles of FOXO1-transgenic (gain-of-function model) and FOXO1,3a,4-/- (loss-of-function model) mice, we identified several novel FOXO1-target genes in skeletal muscle including Redd1, Sestrin1, Castor2, Chac1, Depp1, Lat3, as well as C/EBPδ. During starvation, C/EBPδ abundance was increased in a FOXOs-dependent manner. Notably, knockdown of C/EBPδ prevented the induction of the ubiquitin-proteasome system and decrease of myofibers in FOXO1-activated myotubes. Conversely, C/EBPδ overexpression in primary myotubes induced myotube atrophy. Furthermore, we demonstrated that FOXO1 enhances the promoter activity of target genes in cooperation with C/EBPδ and ATF4. This research comprehensively identifies novel FOXO1 target genes in skeletal muscle and clarifies the pathophysiological role of FOXO1, a master regulator of skeletal muscle atrophy.

    DOI: 10.1096/fj.202101385RR

  • Differential effect of canagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, on slow and fast skeletal muscles from nondiabetic mice. International journal

    Hiroko Otsuka, Hisashi Yokomizo, Shintaro Nakamura, Yoshihiro Izumi, Masatomo Takahashi, Sachiko Obara, Motonao Nakao, Yosuke Ikeda, Naoichi Sato, Ryuichi Sakamoto, Yasutaka Miyachi, Takashi Miyazawa, Takeshi Bamba, Yoshihiro Ogawa

    The Biochemical journal   479 ( 3 )   425 - 444   2022.2

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    DOI: 10.1042/BCJ20210700

  • Comparison of the procedure time differences between hybrid endoscopic submucosal dissection and conventional endoscopic submucosal dissection in patients with early gastric neoplasms: a study protocol for a multi-center randomized controlled trial (Hybrid-G trial). International journal

    Mitsuru Esaki, Eikichi Ihara, Hiroyuki Fujii, Yorinobu Sumida, Kazuhiro Haraguchi, Shunsuke Takahashi, Tsutomu Iwasa, Kayoko Nakano, Masafumi Wada, Shinichi Somada, Yosuke Minoda, Haruei Ogino, Koshiro Tagawa, Yoshihiro Ogawa

    Trials   23 ( 1 )   166 - 166   2022.2

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    DOI: 10.1186/s13063-022-06099-x

  • Pirfenidone attenuates acetaminophen-induced liver injury via suppressing c-Jun N-terminal kinase phosphorylation. International journal

    Shigeki Tashiro, Masatake Tanaka, Takeshi Goya, Tomomi Aoyagi, Miho Kurokawa, Koji Imoto, Akifumi Kuwano, Motoi Takahashi, Hideo Suzuki, Motoyuki Kohjima, Masaki Kato, Yoshihiro Ogawa

    Toxicology and applied pharmacology   434   115817 - 115817   2022.1

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    DOI: 10.1016/j.taap.2021.115817

  • The Efficacy of Tofogliflozin on Metabolic Dysfunction-Associated Fatty Liver Disease

    Takeshi Goya, Koji Imoto, Shigeki Tashiro, Tomomi Aoyagi, Motoi Takahashi, Miho Kurokawa, Hideo Suzuki, Masatake Tanaka, Masaki Kato, Motoyuki Kohjima, Yoshihiro Ogawa

    Gastroenterology Insights   13 ( 1 )   20 - 26   2022.1

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/gastroent13010003

  • Predictive factors of operability after neoadjuvant chemotherapy in resectable or borderline resectable pancreatic cancer: a single-center retrospective study. International journal

    Masatoshi Murakami, Nao Fujimori, Akihisa Ohno, Kazuhide Matsumoto, Katsuhito Teramatsu, Yu Takamatsu, Ayumu Takeno, Takamasa Oono, Toshiya Abe, Noboru Ideno, Naoki Ikenaga, Kohei Nakata, Masafumi Nakamura, Kousei Ishigami, Yoshihiro Ogawa

    Discover. Oncology   13 ( 1 )   2 - 2   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12672-021-00462-1

  • Author Correction: Ascorbic acid during the suckling period is required for proper DNA demethylation in the liver (Scientific Reports, (2020), 10, 1, (21228), 10.1038/s41598-020-77962-7)

    Kenichi Kawahori, Yoshitaka Kondo, Xunmei Yuan, Yuki Kawasaki, Nozomi Hanzawa, Kazutaka Tsujimoto, Fumiko Wada, Takashi Kohda, Akihito Ishigami, Tetsuya Yamada, Yoshihiro Ogawa, Koshi Hashimoto

    Scientific Reports   11 ( 1 )   2021.12

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    DOI: 10.1038/s41598-021-91691-5

  • The Combination of Nucleotide Analog Therapy and Steroid Pulse Therapy for Acute HBV Infection Effectively Promotes HBV Clearance

    Takeshi Goya, Tomoyuki Kurashige, Miho Kurokawa, Masatake Tanaka, Tomomi Aoyagi, Motoi Takahashi, Koji Imoto, Shigeki Tashiro, Hideo Suzuki, Masaki Kato, Motoyuki Kohjima, Yoshihiro Ogawa

    Gastroenterology Insights   13 ( 1 )   1 - 8   2021.12

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    DOI: 10.3390/gastroent13010001

  • Association of Dermal Hypoechogenicity and Cellulitis History in Patients with Lower Extremity Lymphedema: A Cross-Sectional Observational Study. International journal

    Misako Dai, Takeo Minematsu, Yoshihiro Ogawa, Atsuo Kawamoto, Gojiro Nakagami, Hiromi Sanada

    Lymphatic research and biology   2021.11

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    DOI: 10.1089/lrb.2021.0004

  • Rubber band-assisted, one-person-operated cold snare polypectomy for colorectal polyps. International journal

    Misato Esaki, Mitsuru Esaki, Kosuke Maehara, Yosuke Minoda, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa

    Endoscopy international open   9 ( 11 )   E1845-E1846   2021.11

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    DOI: 10.1055/a-1576-7673

  • Subtype-specific trends in the clinical picture of primary aldosteronism over a 13-year period. International journal

    Kohei Saito, Isao Kurihara, Hiroshi Itoh, Takamasa Ichijo, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Takashi Yoneda, Masakatsu Sone, Kenji Oki, Tetsuya Yamada, Hiroki Kobayashi, Kouichi Tamura, Yoshihiro Ogawa, Junji Kawashima, Nobuya Inagaki, Koichi Yamamoto, Masanobu Yamada, Kohei Kamemura, Yuichi Fujii, Tomoko Suzuki, Akihiro Yasoda, Akiyo Tanabe, Mitsuhide Naruse

    Journal of hypertension   39 ( 11 )   2325 - 2332   2021.11

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    DOI: 10.1097/HJH.0000000000002924

  • Rubber band-assisted, one-person-operated cold snare polypectomy for colorectal polyps. International journal

    Misato Esaki, Mitsuru Esaki, Kosuke Maehara, Yosuke Minoda, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa

    Endoscopy international open   9 ( 11 )   E1845-E1846   2021.11

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    DOI: 10.1055/a-1576-7673

  • Mucosal IL23A expression predicts the response to Ustekinumab in inflammatory bowel disease.

    Kei Nishioka, Haruei Ogino, Takatoshi Chinen, Eikichi Ihara, Yoshimasa Tanaka, Kazuhiko Nakamura, Yoshihiro Ogawa

    Journal of gastroenterology   56 ( 11 )   976 - 987   2021.11

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    DOI: 10.1007/s00535-021-01819-7

  • Involvement of interstitial cells of Cajal in nicotinic acetylcholine receptor-induced relaxation of the porcine lower esophageal sphincter. International journal

    Yoshihiro Otsuka, Xiaopeng Bai, Yoshimasa Tanaka, Eikichi Ihara, Takatoshi Chinen, Haruei Ogino, Yoshihiro Ogawa

    European journal of pharmacology   910   174491 - 174491   2021.11

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    DOI: 10.1016/j.ejphar.2021.174491

  • Comparison of efficacy between dipeptidyl peptidase-4 inhibitor and sodium-glucose cotransporter 2 inhibitor on metabolic risk factors in Japanese patients with type 2 diabetes mellitus: Results from the CANTABILE study. International journal

    Cheol Son, Hisashi Makino, Masato Kasahara, Tomohiro Tanaka, Kunihiro Nishimura, S Taneda, Takeshi Nishimura, Shu Kasama, Yoshihiro Ogawa, Yoshihiro Miyamoto, Kiminori Hosoda

    Diabetes research and clinical practice   180   109037 - 109037   2021.10

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    DOI: 10.1016/j.diabres.2021.109037

  • The treatment effects of acotiamide in esophagogastric outflow obstruction: a prospective longitudinal observational study.

    Eikichi Ihara, Haruei Ogino, Kazumasa Muta, Shohei Hamada, Masafumi Wada, Yoshitaka Hata, Hiroko Ikeda, Xiaopeng Bai, Yosuke Minoda, Mitsuru Esaki, Yoshimasa Tanaka, Takatoshi Chinen, Yoshihiro Ogawa

    Esophagus : official journal of the Japan Esophageal Society   2021.10

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    DOI: 10.1007/s10388-021-00887-1

  • Optimization of lymphapheresis for manufacturing autologous CAR-T cells.

    Ikumi Yamanaka, Takuji Yamauchi, Tomoko Henzan, Teppei Sakoda, Kyoko Miyamoto, Hiroyuki Mishima, Hiroaki Ono, Yuhki Koga, Yasuhiro Nakashima, Koji Kato, Toshihiro Miyamoto, Shinichi Mizuno, Yoshihiro Ogawa, Shouichi Ohga, Koichi Akashi, Takahiro Maeda, Yuya Kunisaki

    International journal of hematology   114 ( 4 )   449 - 458   2021.10

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    DOI: 10.1007/s12185-021-03191-x

  • Practice guideline for lipodystrophy syndromes-clinically important diseases of the Japan Endocrine Society (JES).

    Tomohiro Tanaka, Toru Kusakabe, Ken Ebihara, Megumi Aizawa-Abe, Daisuke Aotani, Tohru Yorifuji, Mari Satoh, Yoshihiro Ogawa, Kazuwa Nakao

    Endocrine journal   68 ( 9 )   1027 - 1042   2021.9

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    DOI: 10.1507/endocrj.EJ21-0110

  • Upregulated expression of hypoxia reactive genes in peripheral blood mononuclear cells from chronic liver disease patients. International journal

    Akifumi Kuwano, Masatake Tanaka, Hideo Suzuki, Miho Kurokawa, Koji Imoto, Shigeki Tashiro, Takeshi Goya, Motoyuki Kohjima, Masaki Kato, Yoshihiro Ogawa

    Biochemistry and biophysics reports   27   101068 - 101068   2021.9

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    DOI: 10.1016/j.bbrep.2021.101068

  • The sodium-glucose cotransporter-2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis-associated liver tumors in a novel murine model. International journal

    Naoki Yoshioka, Miyako Tanaka, Kozue Ochi, Akiko Watanabe, Kenji Ono, Makoto Sawada, Tomoo Ogi, Michiko Itoh, Ayaka Ito, Yukihiro Shiraki, Atsushi Enomoto, Masatoshi Ishigami, Mitsuhiro Fujishiro, Yoshihiro Ogawa, Takayoshi Suganami

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie   140   111738 - 111738   2021.8

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    DOI: 10.1016/j.biopha.2021.111738

  • Ipragliflozin Ameliorates Diabetic Nephropathy Associated with Perirenal Adipose Expansion in Mice. International journal

    Hideyuki Okuma, Kentaro Mori, Suguru Nakamura, Tetsuo Sekine, Yoshihiro Ogawa, Kyoichiro Tsuchiya

    International journal of molecular sciences   22 ( 14 )   2021.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms22147329

  • Onigiri esophagography as a screening test for esophageal motility disorders. International journal

    Shohei Hamada, Eikichi Ihara, Kazumasa Muta, Masafumi Wada, Yoshitaka Hata, Hiroko Ikeda, Yoshimasa Tanaka, Haruei Ogino, Takatoshi Chinen, Yoshihiro Ogawa

    Journal of neurogastroenterology and motility   28 ( 1 )   43 - 52   2021.7

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    DOI: 10.5056/jnm20138

  • Mucosa-associated gut microbiota reflects clinical course of ulcerative colitis. International journal

    Yuichiro Nishihara, Haruei Ogino, Masaru Tanaka, Eikichi Ihara, Keita Fukaura, Kei Nishioka, Takatoshi Chinen, Yoshimasa Tanaka, Jiro Nakayama, Dongchon Kang, Yoshihiro Ogawa

    Scientific reports   11 ( 1 )   13743 - 13743   2021.7

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    DOI: 10.1038/s41598-021-92870-0

  • Microcirculatory disturbance in acute liver injury. Invited Reviewed International journal

    Akifumi Kuwano, Miho Kurokawa, Motoyuki Kohjima, Koji Imoto, Shigeki Tashiro, Hideo Suzuki, Masatake Tanaka, Seiji Okada, Masaki Kato, Yoshihiro Ogawa

    Experimental and therapeutic medicine   21 ( 6 )   596 - 596   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/etm.2021.10028

  • Protective Role of DHEAS in Age-related Changes in Bone Mass and Fracture Risk. International journal

    Maki Yokomoto-Umakoshi, Hironobu Umakoshi, Norifusa Iwahashi, Yayoi Matsuda, Hiroki Kaneko, Masatoshi Ogata, Tazuru Fukumoto, Eriko Terada, Yui Nakano, Ryuichi Sakamoto, Yoshihiro Ogawa

    The Journal of clinical endocrinology and metabolism   106 ( 11 )   e4580-e4592 - E4592   2021.6

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    DOI: 10.1210/clinem/dgab459

  • Microcirculatory disturbance in acute liver injury. International journal

    Akifumi Kuwano, Miho Kurokawa, Motoyuki Kohjima, Koji Imoto, Shigeki Tashiro, Hideo Suzuki, Masatake Tanaka, Seiji Okada, Masaki Kato, Yoshihiro Ogawa

    Experimental and therapeutic medicine   21 ( 6 )   596 - 596   2021.6

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    DOI: 10.3892/etm.2021.10028

  • Efficacy of hybrid endoscopic submucosal dissection with SOUTEN in gastric lesions: An ex vivo porcine model basic study. International journal

    Mitsuru Esaki, Eikichi Ihara, Norikazu Hashimoto, Shuichi Abe, Chihoko Aratono, Noriko Shiga, Yorinobu Sumida, Hiroyuki Fujii, Kazuhiro Haraguchi, Shunsuke Takahashi, Tsutomu Iwasa, Kayoko Nakano, Masafumi Wada, Shinichi Somada, Kei Nishioka, Yosuke Minoda, Haruei Ogino, Yoshihiro Ogawa

    World journal of gastrointestinal surgery   13 ( 6 )   563 - 573   2021.6

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    DOI: 10.4240/wjgs.v13.i6.563

  • Author Correction: Ascorbic acid during the suckling period is required for proper DNA demethylation in the liver. International journal

    Kenichi Kawahori, Yoshitaka Kondo, Xunmei Yuan, Yuki Kawasaki, Nozomi Hanzawa, Kazutaka Tsujimoto, Fumiko Wada, Takashi Kohda, Akihito Ishigami, Tetsuya Yamada, Yoshihiro Ogawa, Koshi Hashimoto

    Scientific reports   11 ( 1 )   12184 - 12184   2021.6

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    DOI: 10.1038/s41598-021-91691-5

  • An open-label phase Ⅰ/Ⅱ a clinical trial of 11β-HSD1 inhibitor for Cushing's syndrome and autonomous cortisol secretion. International journal

    106 ( 10 )   e3865-e3880   2021.6

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    CONTEXT: 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors demonstrate anti-metabolic and anti-sarcopenic effects in Cushing's syndrome (CS) and autonomous cortisol secretion (ACS) patients. OBJECTIVE: To confirm the efficacy and safety of S-707106 (11β-HSD1 inhibitor) administered to CS and ACS patients. DESIGN: A 24-week single-center, open-label, single-arm, dose-escalation, investigator-initiated clinical trial on a database. SETTING: Kyushu University Hospital, Kurume University Hospital, and related facilities. PATIENTS: Sixteen patients with inoperable or recurrent CS and ACS, with mildly impaired glucose tolerance. INTERVENTION: Oral administration of 200-mg S-707106 after dinner, daily, for 24 weeks. In patients with insufficient improvement in oral glucose tolerance test results at 12 weeks, an escalated dose of S-707106 (200-mg BID) was administered for the residual 12 weeks. MAIN OUTCOME MEASURES: The rate of participants responding to glucose tolerance impairment, defined as those showing a 25% reduction in the area under the curve (AUC) of plasma glucose during the 75 g-oral glucose tolerance test at 24 weeks. RESULTS: S-707106 administration could not achieve the primary endpoint of this clinical trial (>20% of responsive participants). AUC glucose decreased by -7.1% (SD, 14.8 [90% CI: -14.8- -1.0], P=0.033) and -2.7% (14.5 [-10.2-3.4], P=0.18) at 12 and 24 weeks, respectively. S-707106 administration decreased AUC glucose significantly in participants with a high body mass index. Body fat percentage decreased by -2.5% (1.7 [-3.3- -1.8], P<0.001), and body muscle percentage increased by 2.4% (1.6 [1.7-3.1], P<0.001). CONCLUSIONS: S-707106 is an effective insulin sensitizer and anti-sarcopenic and anti-obesity medication for these patients.

    DOI: 10.1210/clinem/dgab450

  • Bilirubin is inversely related to diabetic peripheral neuropathy assessed by sural nerve conduction study.

    Kentaro Abe, Yasutaka Maeda, Chitose Matsuzaki, Hisashi Yokomizo, Tomoaki Inoue, Noriyuki Sonoda, Yoshihiro Ogawa, Toyoshi Inoguchi

    Journal of diabetes investigation   2021.5

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    DOI: 10.1111/jdi.13568

  • Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor. International journal

    Yukina Takeichi, Takashi Miyazawa, Shohei Sakamoto, Yuki Hanada, Lixiang Wang, Kazuhito Gotoh, Keiichiro Uchida, Shunsuke Katsuhara, Ryuichi Sakamoto, Takaya Ishihara, Keiji Masuda, Naotada Ishihara, Masatoshi Nomura, Yoshihiro Ogawa

    Diabetologia   64 ( 9 )   2092 - 2107   2021.5

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    DOI: 10.1007/s00125-021-05488-2

  • Role of chronic inflammation in the pathogenesis of nonalcoholic steatohepatitis: lessons from a unique mouse model using melanocortin receptor-deficient mice.

    Michiko Itoh, Takayoshi Suganami, Yoshihiro Ogawa

    Endocrine journal   68 ( 7 )   743 - 749   2021.5

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    DOI: 10.1507/endocrj.EJ21-0002

  • Macrophages rely on extracellular serine to suppress aberrant cytokine production. International journal

    Kento Kurita, Hiroya Ohta, Ibuki Shirakawa, Miyako Tanaka, Yasuyuki Kitaura, Yorihiro Iwasaki, Takashi Matsuzaka, Hitoshi Shimano, Seiichiro Aoe, Hiroshi Arima, Yoshihiro Ogawa, Ayaka Ito, Takayoshi Suganami

    Scientific reports   11 ( 1 )   11137 - 11137   2021.5

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    DOI: 10.1038/s41598-021-90086-w

  • Machine learning based models for prediction of subtype diagnosis of primary aldosteronism using blood test. International journal

    Hiroki Kaneko, Hironobu Umakoshi, Masatoshi Ogata, Norio Wada, Norifusa Iwahashi, Tazuru Fukumoto, Maki Yokomoto-Umakoshi, Yui Nakano, Yayoi Matsuda, Takashi Miyazawa, Ryuichi Sakamoto, Yoshihiro Ogawa

    Scientific reports   11 ( 1 )   9140 - 9140   2021.5

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    DOI: 10.1038/s41598-021-88712-8

  • Diverse pathological lesions of primary aldosteronism and their clinical significance. International journal

    Koshiro Nishimoto, Hironobu Umakoshi, Tsugio Seki, Masanori Yasuda, Ryuichiro Araki, Michio Otsuki, Takuyuki Katabami, Hirotaka Shibata, Yoshihiro Ogawa, Norio Wada, Masakatsu Sone, Shintaro Okamura, Shoichiro Izawa, Shozo Miyauchi, Takanobu Yoshimoto, Mika Tsuiki, Mitsuhide Naruse

    Hypertension research : official journal of the Japanese Society of Hypertension   44 ( 5 )   498 - 507   2021.5

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    DOI: 10.1038/s41440-020-00579-w

  • Role of the IL-23-T-bet/GATA3 Axis for the Pathogenesis of Ulcerative Colitis Invited Reviewed International journal

    Haruei Ogino, Keita Fukaura, Yoichiro Iboshi, Yousuke Nagamatsu, Hiroaki Okuno, Kei Nishioka, Yuichiro Nishihara, Yoshimasa Tanaka, Takatoshi Chinen, Eikich Ihara, Yoshihiro Ogawa

    Inflammation   44 ( 2 )   592 - 603   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10753-020-01358-y

  • Physiological and pathological roles of the accommodation response in lower esophageal sphincter relaxation during wet swallows. International journal

    Kazumasa Muta, Eikichi Ihara, Shohei Hamada, Hiroko Ikeda, Masafumi Wada, Yoshitaka Hata, Xiaopeng Bai, Yuichiro Nishihara, Yoshimasa Tanaka, Haruei Ogino, Yoshihiro Ogawa

    Scientific reports   11 ( 1 )   7898 - 7898   2021.4

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    DOI: 10.1038/s41598-021-87052-x

  • High glucose promotes mineralization via bone morphogenetic protein 4-Smad signals in early stage of osteoblast differentiation.

    Ayumu Takeno, Ippei Kanazawa, Ken-Ichiro Tanaka, Masakazu Notsu, Keizo Kanasaki, Takamasa Oono, Yoshihiro Ogawa, Toshitsugu Sugimoto

    Diabetology international   12 ( 2 )   171 - 180   2021.4

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    DOI: 10.1007/s13340-020-00463-5

  • Association of periodontal pocket area with type 2 diabetes and obesity: a cross-sectional study. International journal

    Kohei Takeda, Koji Mizutani, Isao Minami, Daisuke Kido, Risako Mikami, Kuniha Konuma, Natsumi Saito, Hiromi Kominato, Shu Takemura, Keita Nakagawa, Yuichi Izumi, Yoshihiro Ogawa, Takanori Iwata

    BMJ open diabetes research & care   9 ( 1 )   2021.4

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    DOI: 10.1136/bmjdrc-2021-002139

  • AGEs inhibit scavenger receptor class B type I gene expression via Smad1 in HUVECs. Invited Reviewed International journal

    Hiromi Nagata, Jingya Lyu, Hitomi Imachi, Kensaku Fukunaga, Seisuke Sato, Toshihiro Kobayashi, Takanobu Saheki, Kayoko Seo, Japar B Salimah, Hisakazu Iwama, Ryuichi Sakamoto, Yoshihiro Ogawa, Koji Murao

    Journal of molecular endocrinology   66 ( 3 )   223 - 231   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1530/JME-20-0177

  • Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury. International journal

    Nao Hasuzawa, Keita Tatsushima, Lixiang Wang, Masaharu Kabashima, Rie Tokubuchi, Ayako Nagayama, Kenji Ashida, Yoshihiro Ogawa, Yoshinori Moriyama, Masatoshi Nomura

    Scientific reports   11 ( 1 )   5192 - 5192   2021.3

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    DOI: 10.1038/s41598-021-83144-w

  • Age-stratified comparison of clinical outcomes between medical and surgical treatments in patients with unilateral primary aldosteronism. International journal

    Ryo Nakamaru, Koichi Yamamoto, Hiroshi Akasaka, Hiromi Rakugi, Isao Kurihara, Takashi Yoneda, Takamasa Ichijo, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Tetsuya Yamada, Hiroki Kobayashi, Kouichi Tamura, Yoshihiro Ogawa, Junji Kawashima, Nobuya Inagaki, Megumi Fujita, Minemori Watanabe, Kohei Kamemura, Shintaro Okamura, Akiyo Tanabe, Mitsuhide Naruse

    Scientific reports   11 ( 1 )   6925 - 6925   2021.3

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    DOI: 10.1038/s41598-021-86290-3

  • AGEs inhibit scavenger receptor class B type I gene expression via Smad1 in HUVECs. International journal

    Hiromi Nagata, Jingya Lyu, Hitomi Imachi, Kensaku Fukunaga, Seisuke Sato, Toshihiro Kobayashi, Takanobu Saheki, Kayoko Seo, Japar B Salimah, Hisakazu Iwama, Ryuichi Sakamoto, Yoshihiro Ogawa, Koji Murao

    Journal of molecular endocrinology   66 ( 3 )   223 - 231   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1530/JME-20-0177

  • Investigating the causal effect of fibroblast growth factor 23 on osteoporosis and cardiometabolic disorders: A Mendelian randomization study. Invited Reviewed International journal

    Maki Yokomoto-Umakoshi, Hironobu Umakoshi, Takashi Miyazawa, Masatoshi Ogata, Ryuichi Sakamoto, Yoshihiro Ogawa

    Bone   143   115777 - 115777   2021.2

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    DOI: 10.1016/j.bone.2020.115777

  • Discriminant equation using mucosally expressed cytokines and transcription factor for making definite diagnosis of inflammatory bowel disease unclassified. International journal

    Hiroaki Okuno, Haruei Ogino, Eikichi Ihara, Kei Nishioka, Yoshimasa Tanaka, Takatoshi Chinen, Motoyuki Kohjima, Takamasa Oono, Masatake Tanaka, Takeshi Goya, Nao Fujimori, Yoichiro Iboshi, Takuji Gotoda, Yoshihiro Ogawa

    BMC gastroenterology   21 ( 1 )   73 - 73   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12876-021-01656-1

  • Sex Differences in Renal Outcomes After Medical Treatment for Bilateral Primary Aldosteronism. International journal

    Ryo Nakamaru, Koichi Yamamoto, Hiroshi Akasaka, Hiromi Rakugi, Isao Kurihara, Takashi Yoneda, Takamasa Ichijo, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Tetsuya Yamada, Hiroki Kobayashi, Kouichi Tamura, Yoshihiro Ogawa, Junji Kawashima, Nobuya Inagaki, Megumi Fujita, Kenji Oki, Kohei Kamemura, Akiyo Tanabe, Mitsuhide Naruse

    Hypertension (Dallas, Tex. : 1979)   77 ( 2 )   537 - 545   2021.2

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    DOI: 10.1161/HYPERTENSIONAHA.120.16449

  • Iron-rich Kupffer cells exhibit phenotypic changes during the development of liver fibrosis in NASH. International journal

    Yohei Kanamori, Miyako Tanaka, Michiko Itoh, Kozue Ochi, Ayaka Ito, Isao Hidaka, Isao Sakaida, Yoshihiro Ogawa, Takayoshi Suganami

    iScience   24 ( 2 )   102032 - 102032   2021.2

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    DOI: 10.1016/j.isci.2020.102032

  • Investigating the causal effect of fibroblast growth factor 23 on osteoporosis and cardiometabolic disorders: A Mendelian randomization study. International journal

    Maki Yokomoto-Umakoshi, Hironobu Umakoshi, Takashi Miyazawa, Masatoshi Ogata, Ryuichi Sakamoto, Yoshihiro Ogawa

    Bone   143   115777 - 115777   2021.2

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    DOI: 10.1016/j.bone.2020.115777

  • Assistant skill in gastric endoscopic submucosal dissection using a clutch cutter. International journal

    Mitsuru Esaki, Toshiki Horii, Ryoji Ichijima, Masafumi Wada, Seiichiro Sakisaka, Shuichi Abe, Naru Tomoeda, Yusuke Kitagawa, Kei Nishioka, Yosuke Minoda, Shinichi Tsuruta, Sho Suzuki, Hirotada Akiho, Eikichi Ihara, Yoshihiro Ogawa, Takuji Gotoda

    World journal of gastrointestinal surgery   13 ( 2 )   116 - 126   2021.2

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    DOI: 10.4240/wjgs.v13.i2.116

  • Assistant skill in gastric endoscopic submucosal dissection using a clutch cutter. Invited Reviewed International journal

    Mitsuru Esaki, Toshiki Horii, Ryoji Ichijima, Masafumi Wada, Seiichiro Sakisaka, Shuichi Abe, Naru Tomoeda, Yusuke Kitagawa, Kei Nishioka, Yosuke Minoda, Shinichi Tsuruta, Sho Suzuki, Hirotada Akiho, Eikichi Ihara, Yoshihiro Ogawa, Takuji Gotoda

    World journal of gastrointestinal surgery   13 ( 2 )   116 - 126   2021.2

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    DOI: 10.4240/wjgs.v13.i2.116

  • Discriminant equation using mucosally expressed cytokines and transcription factor for making definite diagnosis of inflammatory bowel disease unclassified. Invited Reviewed International journal

    Hiroaki Okuno, Haruei Ogino, Eikichi Ihara, Kei Nishioka, Yoshimasa Tanaka, Takatoshi Chinen, Motoyuki Kohjima, Takamasa Oono, Masatake Tanaka, Takeshi Goya, Nao Fujimori, Yoichiro Iboshi, Takuji Gotoda, Yoshihiro Ogawa

    BMC gastroenterology   21 ( 1 )   73 - 73   2021.2

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    DOI: 10.1186/s12876-021-01656-1

  • Collision of a pancreatic ductal adenocarcinoma and a pancreatic neuroendocrine tumor associated with multiple endocrine neoplasm type 1 Invited Reviewed International journal

    Akihisa Ohno, Nao Fujimori, Masami Miki, Takamasa Oono, Hisato Igarashi, Ryota Matsuda, Yutaka Koga, Yoshinao Oda, Takao Ohtsuka, Masafumi Nakamura, Tetsuhide Ito, Yoshihiro Ogawa

    Clinical Journal of Gastroenterology   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12328-020-01234-0

  • Significance of aldosterone gradient within left adrenal vein in diagnosing unilateral subtype of primary aldosteronism. Invited Reviewed International journal

    Masatoshi Ogata, Hironobu Umakoshi, Tazuru Fukumoto, Yayoi Matsuda, Maki Yokomoto-Umakoshi, Hiromi Nagata, Norio Wada, Takashi Miyazawa, Ryuichi Sakamoto, Yoshihiro Ogawa

    Clinical endocrinology   94 ( 1 )   24 - 33   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cen.14320

  • Significance of Discordant Results Between Confirmatory Tests in Diagnosis of Primary Aldosteronism. International journal

    Tazuru Fukumoto, Hironobu Umakoshi, Masatoshi Ogata, Maki Yokomoto-Umakoshi, Yayoi Matsuda, Misato Motoya, Hiromi Nagata, Yui Nakano, Norifusa Iwahashi, Hiroki Kaneko, Norio Wada, Takashi Miyazawa, Ryuichi Sakamoto, Yoshihiro Ogawa

    The Journal of clinical endocrinology and metabolism   106 ( 2 )   e866-e874   2021.1

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    DOI: 10.1210/clinem/dgaa812

  • Successful endoscopic removal of a fully covered self-expandable metallic stent that fractured above a benign distal bile duct stricture. Invited Reviewed International journal

    Masatoshi Murakami, Nao Fujimori, Yuta Suehiro, Tomonobu Hioki, Kazuhide Matsumoto, Takamasa Oono, Yoshihiro Ogawa

    Endoscopy   53 ( 1 )   E11-E12   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/a-1167-7861

  • Significance of Discordant Results Between Confirmatory Tests in Diagnosis of Primary Aldosteronism. Invited Reviewed International journal

    Tazuru Fukumoto, Hironobu Umakoshi, Masatoshi Ogata, Maki Yokomoto-Umakoshi, Yayoi Matsuda, Misato Motoya, Hiromi Nagata, Yui Nakano, Norifusa Iwahashi, Hiroki Kaneko, Norio Wada, Takashi Miyazawa, Ryuichi Sakamoto, Yoshihiro Ogawa

    The Journal of clinical endocrinology and metabolism   106 ( 2 )   e866-e874   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/clinem/dgaa812

  • Role of deteriorated bone quality in the development of osteoporosis in pheochromocytoma and paraganglioma. Invited Reviewed International journal

    Maki Yokomoto-Umakoshi, Hironobu Umakoshi, Ryuichi Sakamoto, Tazuru Fukumoto, Masatoshi Ogata, Yui Nakano, Norifusa Iwahashi, Hiroki Kaneko, Noriko Mizoguchi, Akiko Hattori, Takashi Miyazawa, Yayoi Matsuda, Hisaya Kawate, Yoshihiro Ogawa

    Bone   142   115607 - 115607   2021.1

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    DOI: 10.1016/j.bone.2020.115607

  • Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis–associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects Reviewed

    10 ( 1 )   2020.12

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    Nonalcoholic steatohepatitis (NASH) is a hepatic phenotype of the metabolic syndrome, and increases the risk of cirrhosis and hepatocellular carcinoma (HCC). Although increasing evidence points to the therapeutic implications of certain types of anti-diabetic agents in NASH, it remains to be elucidated whether their effects on NASH are independent of their effects on diabetes. Genetically obese melanocortin 4 receptor–deficient (MC4R-KO) mice fed Western diet are a murine model that sequentially develops hepatic steatosis, NASH, and HCC in the presence of obesity and insulin resistance. In this study, we investigated the effect of the dipeptidyl peptidase-4 (DPP-4) inhibitor anagliptin on NASH and HCC development in MC4R-KO mice. Anagliptin treatment effectively prevented inflammation, fibrosis, and carcinogenesis in the liver of MC4R-KO mice. Interestingly, anagliptin only marginally affected body weight, systemic glucose and lipid metabolism, and hepatic steatosis. Histological data and gene expression analysis suggest that anagliptin treatment targets macrophage activation in the liver during the progression from simple steatosis to NASH. As a molecular mechanism underlying anagliptin action, we showed that glucagon-like peptide-1 suppressed proinflammatory and profibrotic phenotypes of macrophages in vitro. This study highlights the glucose metabolism–independent effects of anagliptin on NASH and HCC development.

    DOI: 10.1038/s41598-020-57935-6

  • Ascorbic acid during the suckling period is required for proper DNA demethylation in the liver. International journal

    Kenichi Kawahori, Yoshitaka Kondo, Xunmei Yuan, Yuki Kawasaki, Nozomi Hanzawa, Kazutaka Tsujimoto, Fumiko Wada, Takashi Kohda, Akihito Ishigami, Tetsuya Yamada, Yoshihiro Ogawa, Koshi Hashimoto

    Scientific reports   10 ( 1 )   21228 - 21228   2020.12

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    DOI: 10.1038/s41598-020-77962-7

  • Hollow fiber-combined glucose-responsive gel technology as an in vivo electronics-free insulin delivery system Reviewed

    Akira Matsumoto, Hirohito Kuwata, Shinichiro Kimura, Hiroko Matsumoto, Kozue Ochi, Yuki Moro-oka, Akiko Watanabe, Hironori Yamada, Hitoshi Ishii, Taiki Miyazawa, Siyuan Chen, Toshiaki Baba, Hiroshi Yoshida, Taichi Nakamura, Hiroshi Inoue, Yoshihiro Ogawa, Miyako Tanaka, Yuji Miyahara, Takayoshi Suganami

    Communications Biology   3 ( 1 )   2020.12

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    DOI: 10.1038/s42003-020-1026-x

  • Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing Reviewed

    Nozomi Hanzawa, Koshi Hashimoto, Xunmei Yuan, Kenichi Kawahori, Kazutaka Tsujimoto, Miho Hamaguchi, Toshiya Tanaka, Yuya Nagaoka, Hiroshi Nishina, Sumiyo Morita, Izuho Hatada, Tetsuya Yamada, Yoshihiro Ogawa

    Scientific reports   10 ( 1 )   2020.12

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    DOI: 10.1038/s41598-020-62035-6

  • Blocking sphingosine 1-phosphate receptor 2 accelerates hepatocellular carcinoma progression in a mouse model of NASH Reviewed

    Tomoaki Yoshida, Atsunori Tsuchiya, Masaru Kumagai, Suguru Takeuchi, Shunsuke Nojiri, Takayuki Watanabe, Masahiro Ogawa, Michiko Itoh, Masaaki Takamura, Takayoshi Suganami, Yoshihiro Ogawa, Shuji Terai

    Biochemical and Biophysical Research Communications   530 ( 4 )   665 - 672   2020.10

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    DOI: 10.1016/j.bbrc.2020.07.099

  • Perceptions, attitudes and barriers to obesity management: Japanese data from the ACTION-IO study. Reviewed

    Masato Iwabu, Toshimasa Yamauchi, Iichiro Shimomura, Kosei Eguchi, Yoshihiro Ogawa

    Journal of diabetes investigation   12 ( 5 )   845 - 858   2020.10

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    DOI: 10.1111/jdi.13427

  • Collision of a pancreatic ductal adenocarcinoma and a pancreatic neuroendocrine tumor associated with multiple endocrine neoplasm type 1. Reviewed

    Akihisa Ohno, Nao Fujimori, Masami Miki, Takamasa Oono, Hisato Igarashi, Ryota Matsuda, Yutaka Koga, Yoshinao Oda, Takao Ohtsuka, Masafumi Nakamura, Tetsuhide Ito, Yoshihiro Ogawa

    Clinical journal of gastroenterology   14 ( 1 )   358 - 363   2020.9

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    DOI: 10.1007/s12328-020-01234-0

  • Efficacy of endoscopic ultrasound with artificial intelligence for the diagnosis of gastrointestinal stromal tumors. Reviewed

    Yosuke Minoda, Eikichi Ihara, Keishi Komori, Haruei Ogino, Yoshihiro Otsuka, Takatoshi Chinen, Yasuo Tsuda, Koji Ando, Hidetaka Yamamoto, Yoshihiro Ogawa

    Journal of gastroenterology   55 ( 12 )   1119 - 1126   2020.9

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    DOI: 10.1007/s00535-020-01725-4

  • Colonic varices: a rare complication of pancreatic cancer. Reviewed

    Masatoshi Murakami, Nao Fujimori, Yoshihiro Nagao, Tomoharu Yoshizumi, Kazuhide Matsumoto, Sho Yasumori, Katsuhito Teramatsu, Yu Takamatsu, Takamasa Oono, Yoshihiro Ogawa

    Clinical journal of gastroenterology   13 ( 6 )   1355 - 1359   2020.9

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    DOI: 10.1007/s12328-020-01225-1

  • Associations Between Changes in Plasma Renin Activity and Aldosterone Concentrations and Changes in Kidney Function After Treatment for Primary Aldosteronism Reviewed

    Yusuke Kobayashi, Tatsuya Haze, Yuichiro Yano, Kouichi Tamura, Isao Kurihara, Takamasa Ichijo, Takashi Yoneda, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Tetsuya Yamada, Ryuji Okamoto, Megumi Fujita, Kohei Kamemura, Koichi Yamamoto, Shoichiro Izawa, Akiyo Tanabe, Mitsuhide Naruse

    Kidney International Reports   5 ( 8 )   1291 - 1297   2020.8

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    DOI: 10.1016/j.ekir.2020.06.012

  • Significance of Aldosterone Gradient Within Left Adrenal Vein in Diagnosing Unilateral Subtype of Primary Aldosteronism. Reviewed International journal

    Masatoshi Ogata, Hironobu Umakoshi, Tazuru Fukumoto, Yayoi Matsuda, Maki Yokomoto-Umakoshi, Hiromi Nagata, Norio Wada, Takashi Miyazawa, Ryuichi Sakamoto, Yoshihiro Ogawa

    Clinical endocrinology   94 ( 1 )   24 - 33   2020.8

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    DOI: 10.1111/cen.14320

  • Role of Deteriorated Bone Quality in the Development of Osteoporosis in Pheochromocytoma and Paraganglioma. Reviewed International journal

    Maki Yokomoto-Umakoshi, Hironobu Umakoshi, Ryuichi Sakamoto, Tazuru Fukumoto, Masatoshi Ogata, Yui Nakano, Norifusa Iwahashi, Hiroki Kaneko, Noriko Mizoguchi, Akiko Hattori, Takashi Miyazawa, Yayoi Matsuda, Hisaya Kawate, Yoshihiro Ogawa

    Bone   142   115607 - 115607   2020.8

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    DOI: 10.1016/j.bone.2020.115607

  • Negatively charged amino acids in the stalk region of membrane proteins reduce ectodomain shedding Reviewed International journal

    Ryo Iwagishi, Rika Tanaka, Munenosuke Seto, Tomoyo Takagi, Naoko Norioka, Tomoe Ueyama, Teruhisa Kawamura, Junichi Takagi, Yoshihiro Ogawa, Kyoko Shirakabe

    Journal of Biological Chemistry   295 ( 35 )   12343 - 12352   2020.8

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    DOI: 10.1074/jbc.RA120.013758

  • Endoscopic mucosal resection vs endoscopic submucosal dissection for superficial non-ampullary duodenal tumors. Reviewed International journal

    Mitsuru Esaki, Kazuhiro Haraguchi, Kazuya Akahoshi, Naru Tomoeda, Akira Aso, Soichi Itaba, Haruei Ogino, Yusuke Kitagawa, Hiroyuki Fujii, Kazuhiko Nakamura, Masaru Kubokawa, Naohiko Harada, Yosuke Minoda, Sho Suzuki, Eikichi Ihara, Yoshihiro Ogawa

    World journal of gastrointestinal oncology   12 ( 8 )   918 - 930   2020.8

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    DOI: 10.4251/wjgo.v12.i8.918

  • Chronic inflammation as a molecular basis of nonalcoholic steatohepatitis: role of macrophages and fibroblasts in the liver.

    Michiko Itoh, Yoshihiro Ogawa, Takayoshi Suganami

    Nagoya journal of medical science   82 ( 3 )   391 - 397   2020.8

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    DOI: 10.18999/nagjms.82.3.391

  • Blocking sphingosine 1-phosphate receptor 2 accelerates hepatocellular carcinoma progression in a mouse model of NASH. Reviewed International journal

    Tomoaki Yoshida, Atsunori Tsuchiya, Masaru Kumagai, Suguru Takeuchi, Shunsuke Nojiri, Takayuki Watanabe, Masahiro Ogawa, Michiko Itoh, Masaaki Takamura, Takayoshi Suganami, Yoshihiro Ogawa, Shuji Terai

    Biochemical and biophysical research communications   530 ( 4 )   665 - 672   2020.8

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    DOI: 10.1016/j.bbrc.2020.07.099

  • Associations Between Changes in Plasma Renin Activity and Aldosterone Concentrations and Changes in Kidney Function After Treatment for Primary Aldosteronism. Reviewed International journal

    Yusuke Kobayashi, Tatsuya Haze, Yuichiro Yano, Kouichi Tamura, Isao Kurihara, Takamasa Ichijo, Takashi Yoneda, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Tetsuya Yamada, Ryuji Okamoto, Megumi Fujita, Kohei Kamemura, Koichi Yamamoto, Shoichiro Izawa, Akiyo Tanabe, Mitsuhide Naruse

    Kidney international reports   5 ( 8 )   1291 - 1297   2020.8

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    DOI: 10.1016/j.ekir.2020.06.012

  • Endoscopic mucosal resection vs endoscopic submucosal dissection for superficial non-ampullary duodenal tumors Reviewed

    Mitsuru Esaki, Kazuhiro Haraguchi, Kazuya Akahoshi, Naru Tomoeda, Akira Aso, Soichi Itaba, Haruei Ogino, Yusuke Kitagawa, Hiroyuki Fujii, Kazuhiko Nakamura, Masaru Kubokawa, Naohiko Harada, Yosuke Minoda, Sho Suzuki, Eikichi Ihara, Yoshihiro Ogawa

    World Journal of Gastrointestinal Oncology   12 ( 8 )   918 - 930   2020.8

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    DOI: 10.4251/wjgo.v12.i8.918

  • C-type lectin Mincle mediates cell death-triggered inflammation in acute kidney injury Reviewed

    Miyako Tanaka, Marie Saka-Tanaka, Kozue Ochi, Kumiko Fujieda, Yuki Sugiura, Tomofumi Miyamoto, Hiro Kohda, Ayaka Ito, Taiki Miyazawa, Akira Matsumoto, Seiichiro Aoe, Yoshihiro Miyamoto, Naotake Tsuboi, Shoichi Maruyama, Makoto Suematsu, Sho Yamasaki, Yoshihiro Ogawa, Takayoshi Suganami

    Journal of Experimental Medicine   217 ( 11 )   2020.8

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    DOI: 10.1084/JEM.20192230

  • A case of ezetimibe-effective hypercholesterolemia with a novel heterozygous variant in ABCG5. Reviewed

    Yujiro Nakano, Chikara Komiya, Hitomi Shimizu, Hiroyuki Mishima, Kumiko Shiba, Kazutaka Tsujimoto, Kenji Ikeda, Kenichi Kashimada, Sumito Dateki, Koh-Ichiro Yoshiura, Yoshihiro Ogawa, Tetsuya Yamada

    Endocrine journal   67 ( 11 )   1099 - 1105   2020.7

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    DOI: 10.1507/endocrj.EJ20-0044

  • Diabetes Mellitus Itself Increases Cardio-Cerebrovascular Risk and Renal Complications in Primary Aldosteronism. Reviewed International journal

    Aya Saiki, Michio Otsuki, Daisuke Tamada, Tetsuhiro Kitamura, Iichiro Shimomura, Isao Kurihara, Takamasa Ichijo, Yoshiyu Takeda, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Toshihiko Yanase, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Takanobu Yoshimoto, Ryuji Okamoto, Katsutoshi Takahashi, Hiroki Kobayashi, Kouichi Tamura, Kohei Kamemura, Koichi Yamamoto, Shoichiro Izawa, Miki Kakutani, Masanobu Yamada, Akiyo Tanabe, Mitsuhide Naruse

    The Journal of clinical endocrinology and metabolism   105 ( 7 )   2020.7

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    DOI: 10.1210/clinem/dgaa177

  • Coexistence of osteoporosis and atherosclerosis in pheochromocytoma: new insights into its long-term management Reviewed

    M. Yokomoto-Umakoshi, H. Umakoshi, M. Ogata, T. Fukumoto, Y. Matsuda, T. Miyazawa, R. Sakamoto, Y. Ogawa

    Osteoporosis International   2020.7

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00198-020-05527-5

  • Autoimmune gastrointestinal dysmotility: the interface between clinical immunology and neurogastroenterology. Reviewed International journal

    Shunya Nakane, Akihiro Mukaino, Eikichi Ihara, Yoshihiro Ogawa

    Immunological medicine   44 ( 2 )   1 - 12   2020.7

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    DOI: 10.1080/25785826.2020.1797319

  • Activation of the Akt/mammalian target of rapamycin pathway in combined hepatocellular carcinoma and cholangiocarcinoma significant correlation between p-4E-BP1 expression in cholangiocarcinoma component and prognosis Reviewed

    Yukihiko Okumura, Kenichi Kohashi, Yuki Tanaka, Masaki Kato, Yoshihiko Maehara, Yoshihiro Ogawa, Yoshinao Oda

    Virchows Archiv   476 ( 6 )   881 - 890   2020.6

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    DOI: 10.1007/s00428-019-02741-3

  • Natural history and clinical outcomes of pancreatic neuroendocrine neoplasms based on the WHO 2017 classification; a single-center experience of 30 years. Reviewed International journal

    Nao Fujimori, Masami Miki, Lingaku Lee, Kazuhide Matsumoto, Yu Takamatsu, Takehiro Takaoka, Katsuhito Teramatsu, Yuta Suehiro, Masatoshi Murakami, Hisato Igarashi, Takamasa Oono, Takao Ohtsuka, Masafumi Nakamura, Yutaka Koga, Yoshinao Oda, Tetsuhide Ito, Yoshihiro Ogawa

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]   20 ( 4 )   709 - 715   2020.6

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    DOI: 10.1016/j.pan.2020.04.003

  • Nadir Aldosterone Levels After Confirmatory Tests Are Correlated With Left Ventricular Hypertrophy in Primary Aldosteronism. Reviewed International journal

    Youichi Ohno, Masakatsu Sone, Nobuya Inagaki, Akiyuki Kawashima, Yoshiyu Takeda, Takashi Yoneda, Isao Kurihara, Hiroshi Itoh, Mika Tsuiki, Takamasa Ichijo, Takuyuki Katabami, Norio Wada, Ryuichi Sakamoto, Yoshihiro Ogawa, Takanobu Yoshimoto, Tetsuya Yamada, Junji Kawashima, Yuichi Matsuda, Hiroki Kobayashi, Kohei Kamemura, Koichi Yamamoto, Michio Otsuki, Shintaro Okamura, Shoichiro Izawa, Ryuji Okamoto, Kouichi Tamura, Akiyo Tanabe, Mitsuhide Naruse

    Hypertension (Dallas, Tex. : 1979)   75 ( 6 )   1475 - 1482   2020.6

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    DOI: 10.1161/HYPERTENSIONAHA.119.14601

  • Hollow fiber-combined glucose-responsive gel technology as an in vivo electronics-free insulin delivery system. Reviewed International journal

    Akira Matsumoto, Hirohito Kuwata, Shinichiro Kimura, Hiroko Matsumoto, Kozue Ochi, Yuki Moro-Oka, Akiko Watanabe, Hironori Yamada, Hitoshi Ishii, Taiki Miyazawa, Siyuan Chen, Toshiaki Baba, Hiroshi Yoshida, Taichi Nakamura, Hiroshi Inoue, Yoshihiro Ogawa, Miyako Tanaka, Yuji Miyahara, Takayoshi Suganami

    Communications biology   3 ( 1 )   313 - 313   2020.6

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    DOI: 10.1038/s42003-020-1026-x

  • Development of a non-alcoholic steatohepatitis model with rapid accumulation of fibrosis, and its treatment using mesenchymal stem cells and their small extracellular vesicles. Reviewed International journal

    Takayuki Watanabe, Atsunori Tsuchiya, Suguru Takeuchi, Shunsuke Nojiri, Tomoaki Yoshida, Masahiro Ogawa, Michiko Itoh, Masaaki Takamura, Takayoshi Suganami, Yoshihiro Ogawa, Shuji Terai

    Regenerative therapy   14   252 - 261   2020.6

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    DOI: 10.1016/j.reth.2020.03.012

  • Clinico-pathological characteristics of primary adrenal lymphomas - potential efficacy of autologous stem cell transplantation. Reviewed International journal

    Taisuke Narazaki, Motoaki Shiratsuchi, Takamitsu Matsushima, Mariko Tsuda, Yasuhiro Tsukamoto, Hiroki Muta, Toru Masuda, Daisaku Kimura, Akiko Takamatsu, Hidetaka Yamamoto, Yoshinao Oda, Hiroaki Miyoshi, Koichi Ohshima, Yayoi Matsuda, Ryuichi Sakamoto, Yasuhiro Nakashima, Yoshihiro Ogawa

    Leukemia & lymphoma   61 ( 6 )   1516 - 1518   2020.6

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    DOI: 10.1080/10428194.2020.1725507

  • Activation of the Akt/mammalian target of rapamycin pathway in combined hepatocellular carcinoma and cholangiocarcinoma: significant correlation between p-4E-BP1 expression in cholangiocarcinoma component and prognosis. Reviewed International journal

    Yukihiko Okumura, Kenichi Kohashi, Yuki Tanaka, Masaki Kato, Yoshihiko Maehara, Yoshihiro Ogawa, Yoshinao Oda

    Virchows Archiv : an international journal of pathology   476 ( 6 )   881 - 890   2020.6

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    DOI: 10.1007/s00428-019-02741-3

  • Development of a non-alcoholic steatohepatitis model with rapid accumulation of fibrosis, and its treatment using mesenchymal stem cells and their small extracellular vesicles Reviewed

    Takayuki Watanabe, Atsunori Tsuchiya, Suguru Takeuchi, Shunsuke Nojiri, Tomoaki Yoshida, Masahiro Ogawa, Michiko Itoh, Masaaki Takamura, Takayoshi Suganami, Yoshihiro Ogawa, Shuji Terai

    Regenerative Therapy   14   252 - 261   2020.6

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    DOI: 10.1016/j.reth.2020.03.012

  • Human leucocyte antigen DR15, a possible predictive marker for immune checkpoint inhibitor–induced secondary adrenal insufficiency Reviewed

    130   198 - 203   2020.5

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    Background: Immune checkpoint inhibitors (ICPis) induce various immune-related adverse events (irAEs), despite their beneficial effects in treating various advanced cancers. ICPi-induced secondary adrenal insufficiency is described as a prevalent and serious ‘pituitary irAE.’ However, its precise mechanism remains unclear, and no definitive predictive markers have been reported. Patients and methods: We enrolled and studied 11 patients with advanced cancer (aged 39–70 years; 6 male patients) receiving nivolumab, pembrolizumab or ipilimumab who developed pituitary irAEs. Their clinical data, including endocrine functions, were retrospectively assessed and human leucocyte antigen (HLA) genotypes were determined to compare the HLA allele frequencies in these patients and healthy controls. Results: Among 11 patients, 7, 3 and 1 patients exhibited malignant melanoma, non–small-cell lung cancer and gastric cancer, respectively. HLA type screening results revealed that HLA-DR15, B52 and Cw12 were observed in 9, 7, and 7 patients with pituitary irAE, respectively. DR15, B52 and Cw12 were significantly more prevalent in our group than in the healthy control group from the Japanese HLA-haplotype database (this study vs healthy control group); DR15: 81.8% vs 33.5% (n = 11, P = 0.0014), B52: 63.6% vs 21.0% (n = 11, P = 0.0026) and Cw12: 70% vs 21.3% (n = 10, P = 0.0013). Conclusions: HLA-DR15, B52 and Cw12 are possible predisposing factors for pituitary irAEs. HLA-DR15 is reportedly associated with autoimmune disease via interleukin-17 regulation, suggesting its involvement in pituitary irAE development. Using HLA haplotypes as pituitary irAE predictive markers, we could provide safe ICPi treatment and understand irAE pathogenesis.

    DOI: 10.1016/j.ejca.2020.02.049

  • Successful endoscopic removal of a fully covered self-expandable metallic stent that fractured above a benign distal bile duct stricture. Reviewed International journal

    Masatoshi Murakami, Nao Fujimori, Yuta Suehiro, Tomonobu Hioki, Kazuhide Matsumoto, Takamasa Oono, Yoshihiro Ogawa

    Endoscopy   53 ( 1 )   E11-E12   2020.5

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    DOI: 10.1055/a-1167-7861

  • Postoperative renal impairment and longitudinal change in renal function after adrenalectomy in patients with Cushing's syndrome. Reviewed International journal

    Yuki Nakamura, Minato Yokoyama, Soichiro Yoshida, Hajime Tanaka, Toshiki Kijima, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Isao Minami, Takanobu Yoshimoto, Shotaro Naito, Yoshihiro Ogawa, Tetsuya Yamada, Shinichi Uchida, Yasuhisa Fujii

    International journal of urology : official journal of the Japanese Urological Association   27 ( 5 )   395 - 400   2020.5

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    DOI: 10.1111/iju.14205

  • Interleukin-1β as a Predictor of Glucocorticoid Response in Ulcerative Colitis. Reviewed International journal

    1 - 11   2020.5

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    BACKGROUND/AIM: Currently, there are no established biomarkers to differentiate between glucocorticoid (GC)-resistant and GC-sensitive ulcerative colitis (UC); however, interleukin (IL)-1β could be one such candidate biomarker. The aim of this study was to investigate whether mucosally expressed IL-1β could predict the response to GC in patients with UC. METHODS: A total of 27 mucosal tissue samples from 10 patients with GC-resistant UC (GC-resistant group), 9 patients with GC-sensitive UC (GC-sensitive group), and 8 control patients (control group) were analyzed by qRT-PCR for the expression of IL-1β, GC receptor α (GRα), GRβ, and other inflammatory mediators. Rachmilewitz endoscopic index (REI) between the GC-resistant and GC-sensitive groups was matched to avoid any potential influence of inflammation. RESULTS: The REI did not significantly differ between the GC-resistant and GC-sensitive groups. Mucosally expressed IL-1β levels in the GC-resistant group were significantly higher than those in the GC-sensitive group. However, there were no significant differences in the expression levels of GRα, GRβ, and other inflammatory mediators between the 2 groups. We could distinguish between the GC-resistant and GC-sensitive groups with a sensitivity of 90.0% and specificity of 77.8% based on mucosally expressed IL-1β. CONCLUSIONS: Mucosally expressed IL-1β can be used as a predictor of GC response in patients with UC.

    DOI: 10.1159/000507435

  • Human leucocyte antigen DR15, a possible predictive marker for immune checkpoint inhibitor-induced secondary adrenal insufficiency. Reviewed International journal

    Seiichi Yano, Kenji Ashida, Ryuichi Sakamoto, Chihiro Sakaguchi, Masatoshi Ogata, Kengo Maruyama, Shohei Sakamoto, Munehiko Ikeda, Kenji Ohe, Shoko Akasu, Shimpei Iwata, Nobuhiko Wada, Yayoi Matsuda, Yoichi Nakanishi, Masatoshi Nomura, Yoshihiro Ogawa

    European journal of cancer (Oxford, England : 1990)   130   198 - 203   2020.5

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    DOI: 10.1016/j.ejca.2020.02.049

  • Postoperative renal impairment and longitudinal change in renal function after adrenalectomy in patients with Cushing's syndrome Reviewed

    Yuki Nakamura, Minato Yokoyama, Soichiro Yoshida, Hajime Tanaka, Toshiki Kijima, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Isao Minami, Takanobu Yoshimoto, Shotaro Naito, Yoshihiro Ogawa, Tetsuya Yamada, Shinichi Uchida, Yasuhisa Fujii

    International Journal of Urology   27 ( 5 )   395 - 400   2020.5

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    DOI: 10.1111/iju.14205

  • Pheochromocytoma and paraganglioma An emerging cause of secondary osteoporosis Reviewed

    , Maki Yokomoto-Umakoshi, Hironobu Umakoshi, Tazuru Fukumoto, Yayoi Matsuda, Hiromi Nagata, Masatoshi Ogata, Hisaya Kawate, Takashi Miyazawa, Ryuichi Sakamoto, Yoshihiro Ogawa

    Bone   133   2020.4

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    DOI: 10.1016/j.bone.2020.115221

  • Role of Aldosterone and Potassium Levels in Sparing Confirmatory Tests in Primary Aldosteronism. Reviewed International journal

    Hironobu Umakoshi, Ryuichi Sakamoto, Yayoi Matsuda, Maki Yokomoto-Umakoshi, Hiromi Nagata, Tazuru Fukumoto, Masatoshi Ogata, Yoshihiro Ogawa

    The Journal of clinical endocrinology and metabolism   105 ( 4 )   2020.4

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    DOI: 10.1210/clinem/dgz148

  • Risk factors during the early postpartum period for type 2 diabetes mellitus in women with gestational diabetes. Reviewed

    Maki Kawasaki, Naoko Arata, Naoko Sakamoto, Anna Osamura, Siori Sato, Yoshihiro Ogawa, Ichiro Yasuhi, Masako Waguri, Yuji Hiramatsu

    Endocrine journal   67 ( 4 )   427 - 437   2020.4

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    DOI: 10.1507/endocrj.EJ19-0367

  • Pheochromocytoma and paraganglioma: An emerging cause of secondary osteoporosis Reviewed International journal

    Maki Yokomoto-Umakoshi, Hironobu Umakoshi, Tazuru Fukumoto, Yayoi Matsuda, Hiromi Nagata, Masatoshi Ogata, Hisaya Kawate, Takashi Miyazawa, Ryuichi Sakamoto, Yoshihiro Ogawa

    BONE   133   115221 - 115221   2020.4

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    DOI: 10.1016/j.bone.2020.115221

  • Obesity predicts persistence of resistant hypertension after surgery in patients with primary aldosteronism. Reviewed International journal

    Ryo Nakamaru, Koichi Yamamoto, Hiromi Rakugi, Hiroshi Akasaka, Isao Kurihara, Takamasa Ichijo, Yoshiyu Takeda, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Takanobu Yoshimoto, Ryuji Okamoto, Megumi Fujita, Hiroki Kobayashi, Kouichi Tamura, Kohei Kamemura, Shintaro Okamura, Miki Kakutani, Akiyo Tanabe, Mitsuhide Naruse

    Clinical endocrinology   93 ( 3 )   229 - 237   2020.4

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    DOI: 10.1111/cen.14203

  • Basal Plasma Aldosterone Concentration Predicts Therapeutic Outcomes in Primary Aldosteronism. Reviewed International journal

    Aya Saiki, Michio Otsuki, Kosuke Mukai, Reiko Hayashi, Iichiro Shimomura, Isao Kurihara, Takamasa Ichijo, Yoshiyu Takeda, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Takanobu Yoshimoto, Ryuji Okamoto, Katsutoshi Takahashi, Hiroki Kobayashi, Kouichi Tamura, Kohei Kamemura, Koichi Yamamoto, Shoichiro Izawa, Miki Kakutani, Masanobu Yamada, Akiyo Tanabe, Mitsuhide Naruse

    Journal of the Endocrine Society   4 ( 4 )   bvaa011   2020.4

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    DOI: 10.1210/jendso/bvaa011

  • The effect of scissor-type versus non-scissor-type knives on the technical outcomes in endoscopic submucosal dissection for superficial esophageal cancer a multi-center retrospective study Reviewed

    Mitsuru Esaki, Yasuyo Hayashi, Hisatomo Ikehara, Eikichi Ihara, Toshiki Horii, Yu Tamura, Ryoji Ichijima, Shun Yamakawa, Akira Irie, Hitoshi Shibuya, Sho Suzuki, Chika Kusano, Yosuke Minoda, Hirotada Akiho, Yoshihiro Ogawa, Takuji Gotoda

    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus   33 ( 4 )   2020.4

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    DOI: 10.1093/dote/doz077

  • Role of Aldosterone and Potassium Levels in Sparing Confirmatory Tests in Primary Aldosteronism Reviewed

    Hironobu Umakoshi, Ryuichi Sakamoto, Yayoi Matsuda, Maki Yokomoto-Umakoshi, Hiromi Nagata, Tazuru Fukumoto, Masatoshi Ogata, Yoshihiro Ogawa

    The Journal of clinical endocrinology and metabolism   105 ( 4 )   2020.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1210/clinem/dgz148

  • Solid-type poorly differentiated adenocarcinoma of the stomach Deficiency of mismatch repair and SWI/SNF complex Reviewed

    Shinichi Tsuruta, Kenichi Kohashi, Yuichi Yamada, Minako Fujiwara, Yutaka Koga, Eikichi Ihara, Yoshihiro Ogawa, Eiji Oki, Masafumi Nakamura, Yoshinao Oda

    Cancer Science   111 ( 3 )   1008 - 1019   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14301

  • Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing. Reviewed International journal

    Nozomi Hanzawa, Koshi Hashimoto, Xunmei Yuan, Kenichi Kawahori, Kazutaka Tsujimoto, Miho Hamaguchi, Toshiya Tanaka, Yuya Nagaoka, Hiroshi Nishina, Sumiyo Morita, Izuho Hatada, Tetsuya Yamada, Yoshihiro Ogawa

    Scientific reports   10 ( 1 )   5181 - 5181   2020.3

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    DOI: 10.1038/s41598-020-62035-6

  • Solid-type poorly differentiated adenocarcinoma of the stomach: Deficiency of mismatch repair and SWI/SNF complex. Reviewed International journal

    Shinichi Tsuruta, Kenichi Kohashi, Yuichi Yamada, Minako Fujiwara, Yutaka Koga, Eikichi Ihara, Yoshihiro Ogawa, Eiji Oki, Masafumi Nakamura, Yoshinao Oda

    Cancer science   111 ( 3 )   1008 - 1019   2020.3

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    DOI: 10.1111/cas.14301

  • Effect of cosyntropin during adrenal venous sampling on subtype of primary aldosteronism: analysis of surgical outcome. Reviewed International journal

    Hiroki Kobayashi, Yoshihiro Nakamura, Masanori Abe, Isao Kurihara, Hiroshi Itoh, Takamasa Ichijo, Yoshiyu Takeda, Takashi Yoneda, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Yoshihiro Ogawa, Ryuichi Sakamoto, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Takanobu Yoshimoto, Tetsuya Yamada, Ryuji Okamoto, Yuichi Matsuda, Megumi Fujita, Minemori Watanabe, Kouichi Tamura, Akiyo Tanabe, Mitsuhide Naruse

    European journal of endocrinology   182 ( 3 )   265 - 273   2020.3

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    DOI: 10.1530/EJE-19-0860

  • Unilateral primary aldosteronism as an independent risk factor for vertebral fracture Invited Reviewed International journal

    Maki Yokomoto-Umakoshi, Ryuichi Sakamoto, Hironobu Umakoshi, Yayoi Matsuda, Hiromi Nagata, Tazuru Fukumoto, Masatoshi Ogata, Yoshihiro Ogawa

    Clinical Endocrinology   92 ( 3 )   206 - 213   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cen.14145

  • Unilateral primary aldosteronism as an independent risk factor for vertebral fracture Reviewed

    , Maki Yokomoto-Umakoshi, Ryuichi Sakamoto, Hironobu Umakoshi, Yayoi Matsuda, Hiromi Nagata, Tazuru Fukumoto, Masatoshi Ogata, Yoshihiro Ogawa

    Clinical Endocrinology   92 ( 3 )   206 - 213   2020.3

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    DOI: 10.1111/cen.14145

  • Schizophyllum commune sinusitis after allogeneic bone marrow transplantation for myelodysplastic syndrome A case report and literature review Reviewed

    Taisuke Narazaki, Yasuhiro Nakashima, Yasuhiro Tsukamoto, Ruriko Nishida, Mariko Tsuda, Hiroki Muta, Daisaku Kimura, Toru Masuda, Akiko Takamatsu, Kenichi Kohashi, Daisuke Murakami, Motoaki Shiratsuchi, Yoshihiro Ogawa

    Transplant Infectious Disease   22 ( 1 )   2020.2

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    DOI: 10.1111/tid.13205

  • Endoscopic removal of a lumen-apposing metal stent that migrated into the walled-off necrosis during the first drainage procedure. Reviewed International journal

    Nao Fujimori, Yosuke Minoda, Masatoshi Murakami, Yuta Suehiro, Takamasa Oono, Eikichi Ihara, Yoshihiro Ogawa

    Endoscopy   52 ( 2 )   E51-E52   2020.2

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    DOI: 10.1055/a-0992-8900

  • Aberrant activation of bone marrow Ly6C high monocytes in diabetic mice contributes to impaired glucose tolerance Reviewed

    Yosuke Ikeda, Noriyuki Sonoda, Battsetseg Bachuluun, Shinichiro Kimura, Yoshihiro Ogawa, Toyoshi Inoguchi

    PloS one   15 ( 2 )   2020.1

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    DOI: 10.1371/journal.pone.0229401

  • Superiority of mucosal incision-assisted biopsy over ultrasound-guided fine needle aspiration biopsy in diagnosing small gastric subepithelial lesions: a propensity score matching analysis. Reviewed International journal

    Yosuke Minoda, Takatoshi Chinen, Takashi Osoegawa, Soichi Itaba, Kazuhiro Haraguchi, Hirotada Akiho, Akira Aso, Yorinobu Sumida, Keishi Komori, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa

    BMC gastroenterology   20 ( 1 )   19 - 19   2020.1

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    DOI: 10.1186/s12876-020-1170-2

  • Historical changes and between-facility differences in adrenal venous sampling for primary aldosteronism in Japan. Reviewed International journal

    Yuichi Fujii, Yoshiyu Takeda, Isao Kurihara, Hiroshi Itoh, Takuyuki Katabami, Takamasa Ichijo, Norio Wada, Yui Shibayama, Takanobu Yoshimoto, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Katsutoshi Takahashi, Minemori Watanabe, Yuichi Matsuda, Hiroki Kobayashi, Hirotaka Shibata, Kohei Kamemura, Michio Otsuki, Koichi Yamamto, Atsushi Ogo, Toshihiko Yanase, Shintaro Okamura, Shozo Miyauchi, Megumi Fujita, Tomoko Suzuki, Hironobu Umakoshi, Tatsuki Ogasawara, Mika Tsuiki, Mitsuhide Naruse

    Journal of human hypertension   34 ( 1 )   34 - 42   2020.1

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    DOI: 10.1038/s41371-019-0229-4

  • Efficacy of traction, using a clip-with-thread, for esophageal endoscopic submucosal dissection for esophageal lesions with fibrosis in an ex vivo pig training model. Reviewed International journal

    Mitsuru Esaki, Yosuke Minoda, Eikichi Ihara, Seiichiro Sakisaka, Shinichi Tsuruta, Taizo Hosokawa, Masafumi Wada, Yoshitaka Hata, Sho Suzuki, Aya Iwao, Shun Yamakawa, Akira Irie, Hirotada Akiho, Yoshihiro Ogawa

    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology   31 ( 1 )   58 - 64   2020.1

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    DOI: 10.5152/tjg.2020.19207

  • Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis-associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects. Reviewed International journal

    Mitsuhiro Kawakubo, Miyako Tanaka, Kozue Ochi, Akiko Watanabe, Marie Saka-Tanaka, Yohei Kanamori, Naoki Yoshioka, Satoko Yamashita, Moritaka Goto, Michiko Itoh, Ibuki Shirakawa, Sayaka Kanai, Hiromi Suzuki, Makoto Sawada, Ayaka Ito, Masatoshi Ishigami, Mitsuhiro Fujishiro, Hiroshi Arima, Yoshihiro Ogawa, Takayoshi Suganami

    Scientific reports   10 ( 1 )   983 - 983   2020.1

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    DOI: 10.1038/s41598-020-57935-6

  • Superiority of mucosal incision-assisted biopsy over ultrasound-guided fine needle aspiration biopsy in diagnosing small gastric subepithelial lesions A propensity score matching analysis Reviewed

    Yosuke Minoda, Takatoshi Chinen, Takashi Osoegawa, Soichi Itaba, Kazuhiro Haraguchi, Hirotada Akiho, Akira Aso, Yorinobu Sumida, Keishi Komori, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa

    BMC Gastroenterology   20 ( 1 )   2020.1

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    DOI: 10.1186/s12876-020-1170-2

  • Sarcopenic obesity is associated with a faster decline in renal function in people with type 2 diabetes Reviewed

    T. Fukuda, R. Bouchi, M. Asakawa, T. Takeuchi, K. Shiba, K. Tsujimoto, C. Komiya, T. Yoshimoto, Y. Ogawa, T. Yamada

    Diabetic Medicine   37 ( 1 )   105 - 113   2020.1

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    DOI: 10.1111/dme.14153

  • Obesity predicts persistence of resistant hypertension after surgery in patients with primary aldosteronism Reviewed

    , Ryo Nakamaru, Koichi Yamamoto, Hiromi Rakugi, Hiroshi Akasaka, Isao Kurihara, Takamasa Ichijo, Yoshiyu Takeda, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Takanobu Yoshimoto, Ryuji Okamoto, Megumi Fujita, Hiroki Kobayashi, Kouichi Tamura, Kohei Kamemura, Shintaro Okamura, Miki Kakutani, Akiyo Tanabe, Mitsuhide Naruse

    Clinical Endocrinology   2020.1

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    DOI: 10.1111/cen.14203

  • Natural history and clinical outcomes of pancreatic neuroendocrine neoplasms based on the WHO 2017 classification; a single-center experience of 30 years Reviewed

    Nao Fujimori, Masami Miki, Lingaku Lee, Kazuhide Matsumoto, Yu Takamatsu, Takehiro Takaoka, Katsuhito Teramatsu, Yuta Suehiro, Masatoshi Murakami, Hisato Igarashi, Takamasa Oono, Takao Ohtsuka, Masafumi Nakamura, Yutaka Koga, Yoshinao Oda, Tetsuhide Ito, Yoshihiro Ogawa

    Pancreatology   2020.1

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    DOI: 10.1016/j.pan.2020.04.003

  • Historical changes and between-facility differences in adrenal venous sampling for primary aldosteronism in Japan Reviewed

    , Yuichi Fujii, Yoshiyu Takeda, Isao Kurihara, Hiroshi Itoh, Takuyuki Katabami, Takamasa Ichijo, Norio Wada, Yui Shibayama, Takanobu Yoshimoto, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Katsutoshi Takahashi, Minemori Watanabe, Yuichi Matsuda, Hiroki Kobayashi, Hirotaka Shibata, Kohei Kamemura, Michio Otsuki, Koichi Yamamto, Atsushi Ogo, Toshihiko Yanase, Shintaro Okamura, Shozo Miyauchi, Megumi Fujita, Tomoko Suzuki, Hironobu Umakoshi, Tatsuki Ogasawara, Mika Tsuiki, Mitsuhide Naruse, Masanobu Yamada, Hiromi Rakugi, Takashi Kawamura, Osamu Ogawa, Akiyo Tanabe, Tomonobu Hasegawa, Masanori Abe, Ryuichi Sakamoto, Takuro Shinbo, Tatsuya Kai, Tomikazu Fukuoka, Masanori Murakami, Shigeatsu Hashimoto, Makito Tanabe, Mitsuhiro Kometani, Yuichirou Yoshikawa, Youichi Oono, Hisashi Fukuda, Takashi Yoneda

    Journal of human hypertension   34 ( 1 )   34 - 42   2020.1

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    DOI: 10.1038/s41371-019-0229-4

  • Endoscopic removal of a lumen-apposing metal stent that migrated into the walled-off necrosis during the first drainage procedure Reviewed

    Nao Fujimori, Yosuke Minoda, Masatoshi Murakami, Yuta Suehiro, Takamasa Oono, Eikichi Ihara, Yoshihiro Ogawa

    Endoscopy   52 ( 2 )   E51 - E52   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/a-0992-8900

  • Efficacy of traction, using a clip-with-thread, for esophageal endoscopic submucosal dissection for esophageal lesions with fibrosis in an ex vivo pig training model Reviewed

    Mitsuru Esaki, Yosuke Minoda, Eikichi Ihara, Seiichiro Sakisaka, Shinichi Tsuruta, Taizo Hosokawa, Masafumi Wada, Yoshitaka Hata, Sho Suzuki, Aya Iwao, Shun Yamakawa, Akira Irie, Hirotada Akiho, Yoshihiro Ogawa

    Turkish Journal of Gastroenterology   31 ( 1 )   58 - 64   2020.1

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    DOI: 10.5152/tjg.2020.19207

  • Effect of cosyntropin during adrenal venous sampling on subtype of primary aldosteronism Analysis of surgical outcome Reviewed

    , Hiroki Kobayashi, Yoshihiro Nakamura, Masanori Abe, Isao Kurihara, Hiroshi Itoh, Takamasa Ichijo, Yoshiyu Takeda, Takashi Yoneda, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Yoshihiro Ogawa, Ryuichi Sakamoto, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Takanobu Yoshimoto, Tetsuya Yamada, Ryuji Okamoto, Yuichi Matsuda, Megumi Fujita, Minemori Watanabe, Kouichi Tamura, Akiyo Tanabe, Mitsuhide Naruse

    European journal of endocrinology   182 ( 3 )   265 - 273   2020.1

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    DOI: 10.1530/EJE-19-0860

  • Clinico-pathological characteristics of primary adrenal lymphomas–potential efficacy of autologous stem cell transplantation Reviewed

    2020.1

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    DOI: 10.1080/10428194.2020.1725507

  • Autoimmune gastrointestinal dysmotility the interface between clinical immunology and neurogastroenterology Reviewed

    Shunya Nakane, Akihiro Mukaino, Eikichi Ihara, Yoshihiro Ogawa

    Immunological Medicine   2020

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    DOI: 10.1080/25785826.2020.1797319

  • Risk factors during the early postpartum period for type 2 diabetes mellitus in women with gestational diabetes Reviewed

    Maki Kawasaki, Naoko Arata, Naoko Sakamoto, Anna Osamura, Siori Sato, Yoshihiro Ogawa, Ichiro Yasuhi, Masako Waguri, Yuji Hiramatsu

    Endocrine Journal   67 ( 4 )   427 - 437   2020

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    DOI: 10.1507/endocrj.EJ19-0367

  • Nadir Aldosterone Levels after Confirmatory Tests Are Correlated with Left Ventricular Hypertrophy in Primary Aldosteronism Reviewed

    Youichi Ohno, Masakatsu Sone, Nobuya Inagaki, Akiyuki Kawashima, Yoshiyu Takeda, Takashi Yoneda, Isao Kurihara, Hiroshi Itoh, Mika Tsuiki, Takamasa Ichijo, Takuyuki Katabami, Norio Wada, Ryuichi Sakamoto, Yoshihiro Ogawa, Takanobu Yoshimoto, Tetsuya Yamada, Junji Kawashima, Yuichi Matsuda, Hiroki Kobayashi, Kohei Kamemura, Koichi Yamamoto, Michio Otsuki, Shintaro Okamura, Shoichiro Izawa, Ryuji Okamoto, Kouichi Tamura, Akiyo Tanabe, Mitsuhide Naruse

    Hypertension   1475 - 1482   2020

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    DOI: 10.1161/HYPERTENSIONAHA.119.14601

  • Interleukin-1β as a predictor of glucocorticoid response in ulcerative colitis Reviewed

    2020

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    Background/Aim: Currently, there are no established biomarkers to differentiate between glucocorticoid (GC)-resistant and GC-sensitive ulcerative colitis (UC); however, interleukin (IL)-1β could be one such candidate biomarker. The aim of this study was to investigate whether mucosally expressed IL-1β could predict the response to GC in patients with UC. Methods: A total of 27 mucosal tissue samples from 10 patients with GC-resistant UC (GC-resistant group), 9 patients with GC-sensitive UC (GC-sensitive group), and 8 control patients (control group) were analyzed by qRT-PCR for the expression of IL-1β, GC receptor α (GRα), GRβ, and other inflammatory mediators. Rachmilewitz endoscopic index (REI) between the GC-resistant and GC-sensitive groups was matched to avoid any potential influence of inflammation. Results: The REI did not significantly differ between the GC-resistant and GC-sensitive groups. Mucosally expressed IL-1β levels in the GC-resistant group were significantly higher than those in the GC-sensitive group. However, there were no significant differences in the expression levels of GRα, GRβ, and other inflammatory mediators between the 2 groups. We could distinguish between the GC-resistant and GC-sensitive groups with a sensitivity of 90.0% and specificity of 77.8% based on mucosally expressed IL-1β. Conclusions: Mucosally expressed IL-1β can be used as a predictor of GC response in patients with UC.

    DOI: 10.1159/000507435

  • High glucose promotes mineralization via bone morphogenetic protein 4-Smad signals in early stage of osteoblast differentiation Reviewed

    Ayumu Takeno, Ippei Kanazawa, Ken ichiro Tanaka, Masakazu Notsu, Keizo Kanasaki, Takamasa Oono, Yoshihiro Ogawa, Toshitsugu Sugimoto

    Diabetology International   2020

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    DOI: 10.1007/s13340-020-00463-5

  • Coexistence of osteoporosis and atherosclerosis in pheochromocytoma new insights into its long-term management Reviewed

    , M. Yokomoto-Umakoshi, H. Umakoshi, M. Ogata, T. Fukumoto, Y. Matsuda, T. Miyazawa, R. Sakamoto, Y. Ogawa

    Osteoporosis International   2020

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    DOI: 10.1007/s00198-020-05527-5

  • Amelioration of diabetic nephropathy by SGLT2 inhibitors independent of its glucose-lowering effect A possible role of SGLT2 in mesangial cells Reviewed

    Toshinobu Maki, Sayaka Maeno, Yasutaka Maeda, Mayumi Yamato, Noriyuki Sonoda, Yoshihiro Ogawa, Masanori Wakisaka, Toyoshi Inoguchi

    Scientific reports   9 ( 1 )   2019.12

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    DOI: 10.1038/s41598-019-41253-7

  • Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis Reviewed

    Masahiro Asakawa, Michiko Itoh, Takayoshi Suganami, Takeru Sakai, Sayaka Kanai, Ibuki Shirakawa, Xunmei Yuan, Tomomi Hatayama, Shu Shimada, Yoshimitsu Akiyama, Katsuhito Fujiu, Yutaka Inagaki, Ichiro Manabe, Shoji Yamaoka, Tetsuya Yamada, Shinji Tanaka, Yoshihiro Ogawa

    Scientific reports   9 ( 1 )   2019.12

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    DOI: 10.1038/s41598-019-56039-0

  • Poorly controlled diabetes during pregnancy and lactation activates the Foxo1 pathway and causes glucose intolerance in adult offspring Reviewed

    Yukihiro Inoguchi, Kenji Ichiyanagi, Hiroaki Ohishi, Yasutaka Maeda, Noriyuki Sonoda, Yoshihiro Ogawa, Toyoshi Inoguchi, Hiroyuki Sasaki

    Scientific reports   9 ( 1 )   2019.12

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    DOI: 10.1038/s41598-019-46638-2

  • Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis Reviewed

    Jeenat Ferdous Urmi, Hiroaki Itoh, Keiko Muramatsu-Kato, Yukiko Kohmura-Kobayashi, Natsuyo Hariya, Divyanu Jain, Naoaki Tamura, Toshiyuki Uchida, Kazunao Suzuki, Yoshihiro Ogawa, Nobuaki Shiraki, Kazuki Mochizuki, Takeo Kubota, Naohiro Kanayama

    Scientific reports   9 ( 1 )   2019.12

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    DOI: 10.1038/s41598-019-52943-7

  • Intestinal Behçet's Disease with Primary Myelofibrosis Involving Trisomy 8 Reviewed

    142 ( 4 )   253 - 256   2019.11

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    Behçet's disease (BD) is a disorder characterized by systemic inflammation of multiple organs, including the intestines. Several studies have reported a relationship between myelodysplastic syndrome and BD, and trisomy 8 was frequently seen, especially in intestinal BD. However, the association of BD with primary myelofibrosis (PMF) has not been well documented. A 58-year-old Japanese female was diagnosed with PMF in 2014. The symptoms of PMF resolved with ruxolitinib. However, she developed fever and intestinal perforation due to multiple ulcers in the terminal ileum in 2017. Intestinal perforation recurred 1 month later, and the dose of ruxolitinib was tapered. After discontinuation of ruxolitinib, she presented with recurrent oral aphthous ulcers and uveitis. Subsequently, intestinal perforation recurred, and she was diagnosed with intestinal BD. Trisomy 8 was identified in her peripheral blood. She underwent steroid therapy, azathioprine, and infliximab. This case suggests relationships between PMF, trisomy 8, and BD.

    DOI: 10.1159/000501019

  • The Altered Mucosal Barrier Function in the Duodenum Plays a Role in the Pathogenesis of Functional Dyspepsia Reviewed

    Keishi Komori, Eikichi Ihara, Yosuke Minoda, Haruei Ogino, Taisuke Sasaki, Minako Fujiwara, Yoshinao Oda, Yoshihiro Ogawa

    Digestive Diseases and Sciences   64 ( 11 )   3228 - 3239   2019.11

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    DOI: 10.1007/s10620-019-5470-8

  • Bilirubin reduces visceral obesity and insulin resistance by suppression of inflammatory cytokines Reviewed

    Ryoko Takei, Tomoaki Inoue, Noriyuki Sonoda, Motoyuki Kohjima, Misato Okamoto, Ryuichi Sakamoto, Toyoshi Inoguchi, Yoshihiro Ogawa

    PloS one   14 ( 10 )   2019.10

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    DOI: 10.1371/journal.pone.0223302

  • Latent Autonomous Cortisol Secretion from Apparently Nonfunctioning Adrenal Tumor in Nonlateralized Hyperaldosteronism Reviewed

    Youichi Ohno, Masakatsu Sone, Nobuya Inagaki, Yoshiyu Takeda, Isao Kurihara, Mika Tsuiki, Takamasa Ichijo, Norio Wada, Takuyuki Katabami, Yoshihiro Ogawa, Shintaro Okamura, Tomikazu Fukuoka, Tatsuya Kai, Shoichiro Izawa, Yuichiro Yoshikawa, Shigeatsu Hashimoto, Masanobu Yamada, Yoshiro Chiba, Mitsuhide Naruse

    Journal of Clinical Endocrinology and Metabolism   104 ( 10 )   4382 - 4389   2019.10

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    DOI: 10.1210/jc.2018-02790

  • Association between acute fall in estimated glomerular filtration rate after treatment for primary aldosteronism and long-term decline in renal function Reviewed

    Hiroki Kobayashi, Masanori Abe, Yoshihiro Nakamura, Katsutoshi Takahashi, Megumi Fujita, Yoshiyu Takeda, Takashi Yoneda, Isao Kurihara, Hiroshi Itoh, Mika Tsuiki, Norio Wada, Takamasa Ichijo, Takuyuki Katabami, Yoshihiro Ogawa, Junji Kawashima, Takanobu Yoshimoto, Masakatsu Sone, Nobuya Inagaki, Minemori Watanabe, Kohei Kamemura, Yuichi Matsuda, Shoichiro Izawa, Makito Tanabe, Akiyo Tanabe, Tomoko Suzuki, Mitsuhide Naruse

    Hypertension   74 ( 3 )   630 - 638   2019.9

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    DOI: 10.1161/HYPERTENSIONAHA.119.13131

  • Transformation of follicular lymphoma to double-hit lymphoma during adjuvant chemotherapy for concurrent ovarian carcinoma Reviewed

    Taisuke Narazaki, Yasuhiro Nakashima, Yasuhiro Tsukamoto, Mariko Tsuda, Toru Masuda, Daisaku Kimura, Akiko Takamatsu, Koichi Ohshima, Motoaki Shiratsuchi, Yoshihiro Ogawa

    International journal of hematology   110 ( 3 )   375 - 380   2019.9

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    DOI: 10.1007/s12185-019-02656-4

  • Objective validity of the Japan Narrow-Band Imaging Expert Team classification system for the differential diagnosis of colorectal polyps Reviewed

    Yosuke Minoda, Haruei Ogino, Takatoshi Chinen, Eikichi Ihara, Kazuhiro Haraguchi, Hirotada Akiho, Nobuyoshi Takizawa, Akira Aso, Yosuke Tomita, Mitsuru Esaki, Keishi Komori, Yoshihiro Otsuka, Tsutomu Iwasa, Yoshihiro Ogawa

    Digestive Endoscopy   31 ( 5 )   544 - 551   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/den.13393

  • Dynamic nuclear polarization magnetic resonance imaging and the oxygen-sensitive paramagnetic agent OX63 provide a noninvasive quantitative evaluation of kidney hypoxia in diabetic mice Reviewed

    Yoshimi Kodama, Fuminori Hyodo, Mayumi Yamato, K. Yasukawa, Y. Minami, Noriyuki Sonoda, Yoshihiro Ogawa, Kazuhiro Ichikawa, Toyoshi Inoguchi

    Kidney International   96 ( 3 )   787 - 792   2019.9

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    DOI: 10.1016/j.kint.2019.04.034

  • Involvement of different receptor subtypes in prostaglandin E2-induced contraction and relaxation in the lower esophageal sphincter and esophageal body Reviewed

    Xiaopeng Bai, Eikichi Ihara, Yoshihihro Otsuka, Shinichi Tsuruta, Katsuya Hirano, Yoshimasa Tanaka, Haruei Ogino, Mayumi Hirano, Takatoshi Chinen, Hirotada Akiho, Kazuhiko Nakamura, Yoshinao Oda, Yoshihiro Ogawa

    European Journal of Pharmacology   857   2019.8

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    DOI: 10.1016/j.ejphar.2019.172405

  • Sex Difference in the Association between Subtype Distribution and Age at Diagnosis in Patients with Primary Aldosteronism Reviewed

    Hiroshi Akasaka, Koichi Yamamoto, Hiromi Rakugi, Motonori Nagasawa, Ryo Nakamaru, Takamasa Ichijo, Yoshiyu Takeda, Isao Kurihara, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Kohei Kamemura, Takanobu Yoshimoto, Yuichi Matsuda, Megumi Fujita, Hiroki Kobayashi, Minemori Watanabe, Kouichi Tamura, Shintaro Okamura, Shozo Miyauchi, Shoichiro Izawa, Yoshiro Chiba, Akiyo Tanabe, Mitsuhide Naruse

    Hypertension   74 ( 2 )   368 - 374   2019.8

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    DOI: 10.1161/HYPERTENSIONAHA.119.13006

  • Predictors of Clinical Success after Surgery for Primary Aldosteronism in the Japanese Nationwide Cohort Reviewed

    Mitsuha Morisaki, Isao Kurihara, Hiroshi Itoh, Mitsuhide Naruse, Yoshiyu Takeda, Takuyuki Katabami, Takamasa Ichijo, Norio Wada, Takanobu Yoshimoto, Yoshihiro Ogawa, Masakatsu Sone, Mika Tsuiki, Hirotaka Shibata, Junji Kawashima, Megumi Fujita, Minemori Watanabe, Yuichi Matsuda, Hiroki Kobayashi, Tomoko Suzuki

    Journal of the Endocrine Society   3 ( 11 )   2012 - 2022   2019.8

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    DOI: 10.1210/js.2019-00295

  • CLEC3A, MMP7, and LCN2 as novel markers for predicting recurrence in resected G1 and G2 pancreatic neuroendocrine tumors Reviewed

    Masami Miki, Takamasa Oono, Nao Fujimori, Takehiro Takaoka, Ken Kawabe, Yoshihiro Miyasaka, Takao Ohtsuka, Daisuke Saito, Masafumi Nakamura, Yasuyuki Ohkawa, Yoshinao Oda, Mikita Suyama, Tetsuhide Ito, Yoshihiro Ogawa

    Cancer Medicine   8 ( 8 )   3748 - 3760   2019.7

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    DOI: 10.1002/cam4.2232

  • Mucosal incision-assisted biopsy versus endoscopic ultrasound-guided fine-needle aspiration with a rapid on-site evaluation for gastric subepithelial lesions A randomized cross-over study Reviewed

    Takashi Osoegawa, Yosuke Minoda, Eikichi Ihara, Keishi Komori, Akira Aso, Ayako Goto, Soichi Itaba, Haruei Ogino, Kazuhiko Nakamura, Naohiko Harada, Kosuke Makihara, Shinichi Tsuruta, Hidetaka Yamamoto, Yoshihiro Ogawa

    Digestive Endoscopy   31 ( 4 )   413 - 421   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/den.13367

  • Influence of antihypertensive drugs in the subtype diagnosis of primary aldosteronism by adrenal venous sampling Reviewed

    Motonori Nagasawa, Koichi Yamamoto, Hiromi Rakugi, Masao Takeda, Hiroshi Akasaka, Hironobu Umakoshi, Mika Tsuiki, Yoshiyu Takeda, Isao Kurihara, Hiroshi Itoh, Takamasa Ichijo, Takuyuki Katabami, Norio Wada, Yui Shibayama, Takanobu Yoshimoto, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Katsutoshi Takahashi, Megumi Fujita, Minemori Watanabe, Yuichi Matsuda, Hiroki Kobayashi, Hirotaka Shibata, Kohei Kamemura, Michio Otsuki, Yuichi Fujii, Atsushi Ogo, Shintaro Okamura, Shozo Miyauchi, Toshihiko Yanase, Tomoko Suzuki, Takashi Kawamura, Mitsuhide Naruse

    Journal of hypertension   37 ( 7 )   1493 - 1499   2019.7

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    DOI: 10.1097/HJH.0000000000002047

  • Clinical and biochemical outcomes after adrenalectomy and medical treatment in patients with unilateral primary aldosteronism Reviewed

    Takuyuki Katabami, Hisashi Fukuda, Hidekazu Tsukiyama, Yasushi Tanaka, Yoshiyu Takeda, Isao Kurihara, Hiroshi Ito, Mika Tsuiki, Takamasa Ichijo, Norio Wada, Yui Shibayama, Takanobu Yoshimoto, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Katsutoshi Takahashi, Megumi Fujita, Minemori Watanabe, Yuichi Matsuda, Hiroki Kobayashi, Hirotaka Shibata, Kohei Kamemura, Michio Otsuki, Yuichi Fujii, Koichi Yamamoto, Atsushi Ogo, Toshihiko Yanase, Tomoko Suzuki, Mitsuhide Naruse

    Journal of hypertension   37 ( 7 )   1513 - 1520   2019.7

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    DOI: 10.1097/HJH.0000000000002070

  • Mucosally expressed cytokines are associated with the esophageal motility function. Reviewed International journal

    K. Fukaura, E. Ihara, H. Ogino, Y. Iboshi, K. Muta, X. Bai, S. Hamada, Y. Hata, T. Iwasa, A. Aso, K. Nakamura, Y. Ogawa.

    Digestion   98 ( 2 )   95 - 103   2019.6

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    DOI: 10.1159/000487708.

  • Rab8a is involved in membrane trafficking of Kir6.2 in the MIN6 insulinoma cell line Reviewed

    Keiichiro Uchida, Masatoshi Nomura, Tadashi Yamamoto, Yoshihiro Ogawa, Noriyoshi Teramoto

    Pflugers Archiv European Journal of Physiology   471 ( 6 )   877 - 887   2019.6

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    DOI: 10.1007/s00424-018-02252-1

  • Ipragliflozin-induced adipose expansion inhibits cuff-induced vascular remodeling in mice Reviewed

    Kentaro Mori, Kyoichiro Tsuchiya, Suguru Nakamura, Yasutaka Miyachi, Kumiko Shiba, Yoshihiro Ogawa, Kenichiro Kitamura

    Cardiovascular Diabetology   18 ( 1 )   2019.6

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    DOI: 10.1186/s12933-019-0886-1

  • Gastric hepatoid adenocarcinomas are a genetically heterogenous group; most tumors show chromosomal instability, but MSI tumors do exist Reviewed

    Shinichi Tsuruta, Yoshihiro Ohishi, Minako Fujiwara, Eikichi Ihara, Yoshihiro Ogawa, Eiji Oki, Masafumi Nakamura, Yoshinao Oda

    Human Pathology   88   27 - 38   2019.6

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    DOI: 10.1016/j.humpath.2019.03.006

  • Effects of oral health instructions on glycemic control and oral health status of periodontitis patients with type 2 diabetes mellitus A preliminary observation Reviewed

    Kanako Toda, Koji Mizutani, Isao Minami, Ming Ye, Takahiro Arakawa, Kohji Mitsubayashi, Yoshihiro Ogawa, Kouji Araki, Kayoko Shinada

    Journal of Dental Sciences   14 ( 2 )   171 - 177   2019.6

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    DOI: 10.1016/j.jds.2019.01.009

  • Impact of adrenocorticotropic hormone stimulation during adrenal venous sampling on outcomes of primary aldosteronism Reviewed

    Yoshiyu Takeda, Hironobu Umakoshi, Yoshimichi Takeda, Takashi Yoneda, Isao Kurihara, Takuyuki Katabami, Takamasa Ichijo, Norio Wada, Takanobu Yoshimoto, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Katsutoshi Takahashi, Minemori Watanabe, Yuichi Matsuda, Hiroki Kobayashi, Hirotaka Shibata, Kohei Kamemura, Michio Otsuki, Yuichi Fujii, Koichi Yamamto, Atsushi Ogo, Toshihiko Yanase, Tomoko Suzuki, Mitsuhide Naruse

    Journal of hypertension   37 ( 5 )   1077 - 1082   2019.5

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    DOI: 10.1097/HJH.0000000000001964

  • Evaluation of hepatic function using dynamic contrast-enhanced magnetic resonance imaging in melanocortin 4 receptor-deficient mice as a model of nonalcoholic steatohepatitis Reviewed

    Tomomi Yamada, Yuto Kashiwagi, Takemi Rokugawa, Hideaki Kato, Haruyo Konishi, Tadateru Hamada, Ryohei Nagai, Yusaku Masago, Michiko Itoh, Takayoshi Suganami, Yoshihiro Ogawa, Kohji Abe

    Magnetic Resonance Imaging   57   210 - 217   2019.4

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    DOI: 10.1016/j.mri.2018.11.013

  • Relapse patterns and predictors of IgG4-related diseases involved with autoimmune pancreatitis A single-center retrospective study of 115 patients Reviewed

    Masami Miki, Nao Fujimori, Takamasa Oono, Ken Kawabe, Akihisa Ohno, Kazuhide Matsumoto, Katsuhito Teramatsu, Yuichi Tachibana, Yoshihiro Ogawa

    Journal of Digestive Diseases   20 ( 3 )   152 - 158   2019.3

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    DOI: 10.1111/1751-2980.12708

  • A case of nivolumab-induced acute-onset type 1 diabetes mellitus in melanoma Reviewed

    C. Sakaguchi, K. Ashida, S. Yano, K. Ohe, N. Wada, N. Hasuzawa, Y. Matsuda, S. Sakamoto, R. Sakamoto, H. Uchi, M. Furue, M. Nomura, Y. Ogawa

    Current oncology (Toronto, Ont.)   26 ( 1 )   e115 - e118   2019.2

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    DOI: 10.3747/co.26.4130

  • Secretion of a gastrointestinal hormone, cholecystokinin, by hop-derived bitter components activates sympathetic nerves in brown adipose tissue Reviewed

    Takahiro Yamazaki, Yumie Morimoto-Kobayashi, Kumiko Koizumi, Chika Takahashi, Shiori Nakajima, Sayoko Kitao, Yoshimasa Taniguchi, Mikio Katayama, Yoshihiro Ogawa

    Journal of Nutritional Biochemistry   64   80 - 87   2019.2

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    DOI: 10.1016/j.jnutbio.2018.10.009

  • The altered mucosal barrier function in the duodenum plays a role in the pathogenesis of functional dyspepsia. Reviewed International journal

    K. Komori, E. Ihara, Y. Minoda, H.Ogino, T. Sasaki, M. Fujiwara, Y. Oda, Y. Ogawa.

    Dig Dis Sci.   2019.1

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    DOI: 10.1007/s10620-019-5470-8.

  • Lateralizing asymmetry of adrenal imaging and adrenal vein sampling in patients with primary aldosteronism Reviewed

    , Norio Wada, Yui Shibayama, Takashi Yoneda, Takuyuki Katabami, Isao Kurihara, Mika Tsuiki, Takamasa Ichijo, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Takanobu Yoshimoto, Yuichi Matsuda, Megumi Fujita, Hiroki Kobayashi, Kouichi Tamura, Kohei Kamemura, Michio Otsuki, Shintaro Okamura, Mitsuhide Naruse

    Journal of the Endocrine Society   3 ( 7 )   1393 - 1402   2019.1

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    DOI: 10.1210/js.2019-00131

  • A case of autonomous cortisol secretion in a patient with subclinical Cushing's syndrome, GNAS mutation, and paradoxical cortisol response to dexamethasone Reviewed

    Chihiro Sakaguchi, Kenji Ashida, Kenichi Kohashi, Kenji Ohe, Yoichi Fujii, Seiichi Yano, Yayoi Matsuda, Shohei Sakamoto, Ryuichi Sakamoto, Yoshinao Oda, Masatoshi Nomura, Yoshihiro Ogawa

    BMC Endocrine Disorders   19 ( 1 )   2019.1

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    DOI: 10.1186/s12902-019-0345-8

  • A case of acute exacerbation of chronic adrenal insufficiency due to ipilimumab treatment for advanced melanoma Reviewed

    Chihiro Sakaguchi, Seiichi Yano, Kenji Ashida, Naoko Wada, Kenji Ohe, Hiromi Nagata, Yayoi Matsuda, Shohei Sakamoto, Ryuichi Sakamoto, Keizo Ohnaka, Hiroshi Uchi, Masutaka Furue, Masatoshi Nomura, Yoshihiro Ogawa

    American Journal of Case Reports   20   106 - 110   2019

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    DOI: 10.12659/AJCR.913021

  • Successful endoscopic treatment of hepatoduodenal fistula formed during sorafenib treatment for hepatocellular carcinoma with duodenal invasion Reviewed

    Koji Imoto, Motoyuki Kohjima, Tomoyuki Kurashige, Taiji Mutsuki, Shigeki Tashiro, Hideo Suzuki, Akifumi Kuwano, Masaki Kato, Yoshihiro Ogawa

    Acta Hepatologica Japonica   60 ( 3 )   91 - 98   2019

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    DOI: 10.2957/kanzo.60.91

  • Self-Completion Method of Endoscopic Submucosal Dissection Using Endosaber without Any Other Device or Assistance An ex vivo Porcine Model Study Reviewed

    Mitsuru Esaki, Yosuke Minoda, Masafumi Wada, Seiichiro Sakisaka, Shinichi Tsuruta, Taizo Hosokawa, Takahiro Matsuguchi, Ryoji Ichijima, Sho Suzuki, Yu Tamura, Aya Iwao, Shun Yamakawa, Akira Irie, Eikichi Ihara, Yoshihiro Ogawa

    Digestion   2019

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    DOI: 10.1159/000502771

  • Renal impairment is closely associated with plasma aldosterone concentration in patients with primary aldosteronism Reviewed

    , Akiyuki Kawashima, Masakatsu Sone, Nobuya Inagaki, Yoshiyu Takeda, Hiroshi Itoh, Isao Kurihara, Hironobu Umakoshi, Takamasa Ichijo, Takuyuki Katabami, Norio Wada, Yoshihiro Ogawa, Junji Kawashima, Megumi Fujita, Shozo Miyauchi, Shintaro Okamura, Tomikazu Fukuoka, Toshihiko Yanase, Shoichiro Izawa, Yuichiro Yoshikawa, Shigeatsu Hashimoto, Masanobu Yamada, Tatsuya Kai, Tomoko Suzuki, Mitsuhide Naruse

    European journal of endocrinology   181 ( 3 )   339 - 350   2019

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    DOI: 10.1530/EJE-19-0047

  • Mucosal Profiles of Immune Molecules Related to T Helper and Regulatory T Cells Predict Future Relapse in Patients with Quiescent Ulcerative Colitis Reviewed

    Keita Fukaura, Yoichiro Iboshi, Haruei Ogino, Eikichi Ihara, Kazuhiko Nakamura, Yuichiro Nishihara, Kei Nishioka, Takatoshi Chinen, Tsutomu Iwasa, Akira Aso, Ayako Goto, Kazuhiro Haraguchi, Hirotada Akiho, Naohiko Harada, Yoshihiro Ogawa

    Inflammatory bowel diseases   25 ( 6 )   1019 - 1027   2019

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    DOI: 10.1093/ibd/izy395

  • MiRNA299 involvement in CYP11B2 expression in aldosterone-producing adenoma Reviewed

    Yujiro Nakano, Takanobu Yoshimoto, Ryo Watanabe, Masanori Murakami, Tatsuya Fukuda, Kazutaka Saito, Yasuhisa Fujii, Takumi Akashi, Toshihiro Tanaka, Tetsuya Yamada, Mitsuhide Naruse, Yoshihiro Ogawa

    European journal of endocrinology   181 ( 1 )   69 - 78   2019

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    DOI: 10.1530/EJE-18-0882

  • Fulminant type 1 diabetes mellitus following acute pancreatitis and hypoglycemia with sequential imaging of the pancreas using computed tomography A case report Reviewed

    Tsukasa Miyagahara, Nao Fujimori, Takamasa Oono, Misato Okamoto, Naoichi Sato, Noriyuki Sonoda, Kenichi Kohashi, Kousei Ishigami, Yoshihiro Ogawa

    Journal of Japanese Society of Gastroenterology   116 ( 2 )   161 - 167   2019

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    DOI: 10.11405/nisshoshi.116.161

  • Endoscopic retrograde cholangiopancreatography in patients with surgically altered gastrointestinal anatomy A retrospective study Reviewed

    Takaaki Fujimoto, Yasuhisa Mori, Yohei Nakashima, Takao Ohtsuka, So Nakamura, Yoshitaka Gotoh, Kenjiro Date, Yoshihiko Sadakari, Kohei Nakata, Yoshihiro Miyasaka, Takashi Osoegawa, Akira Aso, Eikichi Ihara, Kazuhiko Nakamura, Yoshihiro Ogawa, Shuji Shimizu, Masafumi Nakamura

    International Surgery   103 ( 3-4 )   184 - 190   2019

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    DOI: 10.9738/INTSURG-D-17-00137.1

  • Clinical outcomes of 20 Japanese patients with insulinoma treated with diazoxide Reviewed

    Yoshihiro Niitsu, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Fuminori Satou, Motoyoshi Tsujino, Kazuki Ota, Atsushi Kudo, Minoru Tanabe, Tetsuya Yamada, Yoshihiro Ogawa

    Endocrine Journal   66 ( 2 )   149 - 155   2019

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    DOI: 10.1507/endocrj.EJ18-0353

  • Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients Reviewed

    Koji Imoto, Motoyuki Kohjima, Tomonobu Hioki, Tomoyuki Kurashige, Miho Kurokawa, Shigeki Tashiro, Hideo Suzuki, Akifumi Kuwano, Masatake Tanaka, Seiji Okada, Masaki Kato, Yoshihiro Ogawa

    Canadian Journal of Gastroenterology and Hepatology   2019   2019

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    DOI: 10.1155/2019/6391712

  • Clinical Characterization of Vonoprazan-Refractory Gastroesophageal Reflux Disease Reviewed

    Shohei Hamada, Eikichi Ihara, Hiroko Ikeda, Kazumasa Muta, Haruei Ogino, Takatoshi Chinen, Yoshimasa Tanaka, Yoshihiro Ogawa

    Digestion   2019

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    DOI: 10.1159/000503340

  • A reduced M1-like/M2-like ratio of macrophages in healthy adipose tissue expansion during SGLT2 inhibition Reviewed

    Yasutaka Miyachi, Kyoichiro Tsuchiya, Kumiko Shiba, Kentaro Mori, Chikara Komiya, Naomi Ogasawara, Yoshihiro Ogawa

    Scientific reports   8 ( 1 )   2018.12

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    DOI: 10.1038/s41598-018-34305-x

  • Upshaw-Schulman syndrome diagnosed during pregnancy complicated by reversible cerebral vasoconstriction syndrome Reviewed

    Mariko Tsuda, Motoaki Shiratsuchi, Yasuhiro Nakashima, Motohiko Ikeda, Hiroki Muta, Taisuke Narazaki, Toru Masuda, Daisaku Kimura, Akiko Takamatsu, Masanori Matsumoto, Yoshihiro Fujimura, Koichi Kokame, Takamitsu Matsushima, Yoshihiro Ogawa

    Transfusion and Apheresis Science   57 ( 6 )   790 - 792   2018.12

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    DOI: 10.1016/j.transci.2018.10.023

  • P66Shc Signaling Mediates Diabetes-Related Cognitive Decline Reviewed

    Yohei Minami, Noriyuki Sonoda, Eiichi Hayashida, Hiroaki Makimura, Makoto Ide, Noriko Ikeda, Masahiro Ohgidani, Takahiro A. Kato, Yoshihiro Seki, Yasutaka Maeda, Shigenobu Kanba, Ryoichi Takayanagi, Yoshihiro Ogawa, Toyoshi Inoguchi

    Scientific reports   8 ( 1 )   2018.12

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    DOI: 10.1038/s41598-018-21426-6

  • Obeticholic acid protects against hepatocyte death and liver fibrosis in a murine model of nonalcoholic steatohepatitis Reviewed

    Toshihiro Goto, Michiko Itoh, Takayoshi Suganami, Sayaka Kanai, Ibuki Shirakawa, Takeru Sakai, Masahiro Asakawa, Toshihiro Yoneyama, Toshihiro Kai, Yoshihiro Ogawa

    Scientific reports   8 ( 1 )   2018.12

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    DOI: 10.1038/s41598-018-26383-8

  • Clutch Cutter knife efficacy in endoscopic submucosal dissection for early gastric neoplasms Reviewed

    Yasuyo Hayashi, Mitsuru Esaki, Sho Suzuki, Eikichi Ihara, Azusa Yokoyama, Seiichiro Sakisaka, Taizo Hosokawa, Yoshimasa Tanaka, Takahiro Mizutani, Shinichi Tsuruta, Aya Iwao, Shun Yamakawa, Akira Irie, Yosuke Minoda, Yoshitaka Hata, Haruei Ogino, Hirotada Akiho, Yoshihiro Ogawa

    World Journal of Gastrointestinal Oncology   10 ( 12 )   487 - 495   2018.12

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    DOI: 10.4251/wjgo.v10.i12.487

  • Canagliflozin, an SGLT2 inhibitor, attenuates the development of hepatocellular carcinoma in a mouse model of human NASH Reviewed

    Kumiko Shiba, Kyoichiro Tsuchiya, Chikara Komiya, Yasutaka Miyachi, Kentaro Mori, Noriko Shimazu, Shinobu Yamaguchi, Naomi Ogasawara, Makoto Katoh, Michiko Itoh, Takayoshi Suganami, Yoshihiro Ogawa

    Scientific reports   8 ( 1 )   2018.12

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    DOI: 10.1038/s41598-018-19658-7

  • Anti-ganglionic AChR antibodies in Japanese patients with motility disorders Reviewed

    Akihiro Mukaino, Hitomi Minami, Hajime Isomoto, Hitomi Hamamoto, Eikichi Ihara, Yasuhiro Maeda, Osamu Higuchi, Tohru Okanishi, Yohei Kokudo, Kazushi Deguchi, Fumisato Sasaki, Toshihito Ueki, Ken ya Murata, Takeshi Yoshida, Mistuyo Kinjo, Yoshihiro Ogawa, Akio Ido, Hidenori Matsuo, Kazuhiko Nakao, Shunya Nakane

    Journal of gastroenterology   53 ( 12 )   1227 - 1240   2018.12

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    DOI: 10.1007/s00535-018-1477-8

  • Clinical characteristics and postoperative outcomes of primary aldosteronism in the elderly Reviewed

    Masao Takeda, Koichi Yamamoto, Hiroshi Akasaka, Hiromi Rakugi, Mitsuhide Naruse, Yoshiyu Takeda, Isao Kurihara, Hiroshi Itoh, Hironobu Umakoshi, Mika Tsuiki, Takamasa Ichijo, Takuyuki Katabami, Norio Wada, Yui Shibayama, Takanobu Yoshimoto, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Katsutoshi Takahashi, Megumi Fujita, Minemori Watanabe, Yuichi Matsuda, Hiroki Kobayashi, Hirotaka Shibata, Kohei Kamemura, Michio Otsuki, Yuichi Fujii, Atsushi Ogo, Shintaro Okamura, Shozo Miyauchi, Toshihiko Yanase, Tomoko Suzuki, Takashi Kawamura

    Journal of Clinical Endocrinology and Metabolism   103 ( 10 )   3620 - 3629   2018.10

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    DOI: 10.1210/jc.2018-00059

  • Acquired hemophilia A associated with autoimmune pancreatitis with serum IgG4 elevation Reviewed

    Taisuke Narazaki, Shojiro Haji, Yasuhiro Nakashima, Yasuhiro Tsukamoto, Mariko Tsuda, Akiko Takamatsu, Hirofumi Ohno, Takamitsu Matsushima, Tomoko Matsumoto, Keiji Nogami, Midori Shima, Motoaki Shiratsuchi, Yoshihiro Ogawa

    International journal of hematology   108 ( 3 )   335 - 338   2018.9

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    DOI: 10.1007/s12185-018-2441-3

  • Effects of high fructose intake on liver injury progression in high fat diet induced fatty liver disease in ovariectomized female mice. Reviewed International journal

    T. Ohashi, M. Kato, A. Yamasaki, A. Kuwano, H. Suzuki, M. Kohjima, and Y. Ogawa.

    Food Chem Toxicol   118   190 - 197   2018.8

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    DOI: 10.1016/j.fct.2018.05.006.

  • Propensity score-matching analysis to compare clinical outcomes of endoscopic submucosal dissection for early gastric cancer in the postoperative and non-operative stomachs Reviewed

    Mitsuru Esaki, Sho Suzuki, Yasuyo Hayashi, Azusa Yokoyama, Shuichi Abe, Taizo Hosokawa, Shinichi Tsuruta, Yosuke Minoda, Yoshitaka Hata, Haruei Ogino, Hirotada Akiho, Eikichi Ihara, Yoshihiro Ogawa

    BMC Gastroenterology   18 ( 1 )   2018.8

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    DOI: 10.1186/s12876-018-0855-2

  • Mucosally Expressed Cytokines are Associated with the Esophageal Motility Function Reviewed

    Keita Fukaura, Eikichi Ihara, Haruei Ogino, Yoichiro Iboshi, Kazumasa Muta, Bai Xiaopeng, Shohei Hamada, Yoshitaka Hata, Tsutomu Iwasa, Akira Aso, Kazuhiko Nakamura, Yoshihiro Ogawa

    Digestion   98 ( 2 )   95 - 103   2018.8

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    DOI: 10.1159/000487708

  • Methotrexate-associated lymphoproliferative disorders with angioimmunoblastic T-cell lymphoma-like features accompanied by gamma-heavy chain disease in a patient with rheumatoid arthritis Reviewed

    Junichi Kiyasu, Fumiko Arakawa, Shojiro Haji, Yoshimichi Tachikawa, Mariko Tsuda, Yasuhiro Tsukamoto, Motohiko Ikeda, Hiroki Muta, Takamitsu Matsushima, Hiroaki Miyoshi, Motoaki Shiratsuchi, Yoshihiro Ogawa, Kouichi Ohshima, Yuji Yufu

    Pathology International   68 ( 8 )   485 - 490   2018.8

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    DOI: 10.1111/pin.12703

  • Effects of high fructose intake on liver injury progression in high fat diet induced fatty liver disease in ovariectomized female mice Reviewed

    Tomoko Ohashi, Masaki Kato, Akihiro Yamasaki, Akifumi Kuwano, Hideo Suzuki, Motoyuki Kohjima, Yoshihiro Ogawa

    Food and Chemical Toxicology   118   190 - 197   2018.8

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    DOI: 10.1016/j.fct.2018.05.006

  • Correlation between lateralization index of adrenalvenoussamplingandstandardized outcome in primary aldosteronism Reviewed

    Hironobu Umakoshi, Mika Tsuiki, Maki Yokomoto-Umakoshi, Yoshiyu Takeda, Yoneda Takashi, Isao Kurihara, Hiroshi Itoh, Takuyuki Katabami, Takamasa Ichijo, Norio Wada, Yui Shibayama, Takanobu Yoshimoto, Kenji Ashida, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Katsutoshi Takahashi, Minemori Watanabe, Yuichi Matsuda, Hiroki Kobayashi, Hirotaka Shibata, Kohei Kamemura, Michio Otsuki, Yuichi Fujii, Koichi Yamamto, Atsushi Ogo, Shintaro Okamura, Shozo Miyauchi, Tomikazu Fukuoka, Shoichiro Izawa, Toshihiko Yanase, Shigeatsu Hashimoto, Masanobu Yamada, Yuichiro Yoshikawa, Tatsuya Kai, Tomoko Suzuki, Takashi Kawamura, Mitsuhide Naruse

    Journal of the Endocrine Society   2 ( 8 )   893 - 902   2018.8

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    DOI: 10.1210/JS.2018-00055

  • Propensity score-matching analysis to compare clinical outcomes of endoscopic submucosal dissection for early gastric cancer in the postoperative and non-operative stomachs. Reviewed International journal

    M. Esaki, S. Suzuki, Y. Hayashi, A. Yokoyama, S. Abe, T. Hosokawa, S. Tsuruta, Y. Minoda, Y. Hata, H. Ogino, H. Akiho, E. Ihara and Y. Ogawa.

    BMC Gastroenterol   18 ( 1 )   125   2018.8

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    DOI: 10.1186/s12876-018-0855-2.

  • A new robotic-assisted flexible endoscope with single-hand control: endoscopic submucosal dissection in the ex vivo porcine stomach. Reviewed International journal

    T. Iwasa, R. Nakadate, S. Onogi, Y. Okamoto, J. Arata, S. Oguri, H. Ogino H, E. Ihara, K. Ohuchida, T. Akahoshi, T. Ikeda, Y. Ogawa, M. Hashizume.

    Surgical Endoscopy   32 ( 7 )   3386 - 3392   2018.7

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    DOI: 10.1007/s00464-018-6188-y.

  • A new robotic-assisted flexible endoscope with single-hand control endoscopic submucosal dissection in the ex vivo porcine stomach Reviewed

    Tsutomu Iwasa, Ryu Nakadate, Shinya Onogi, Yasuharu Okamoto, Jumpei Arata, Susumu Oguri, Haruei Ogino, Eikichi Ihara, Kenoki Ohuchida, Tomohiko Akahoshi, Tetsuo Ikeda, Yoshihiro Ogawa, Makoto Hashizume

    Surgical endoscopy   32 ( 7 )   3386 - 3392   2018.7

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    DOI: 10.1007/s00464-018-6188-y

  • Nivolumab-induced thyroid dysfunction lacking antithyroid antibody is frequently evoked in Japanese patients with malignant melanoma Reviewed

    Seiichi Yano, Kenji Ashida, Hiromi Nagata, Kenji Ohe, Naoko Wada, Yukina Takeichi, Yuki Hanada, Yuta Ibayashi, Lixiang Wang, Shohei Sakamoto, Ryuichi Sakamoto, Hiroshi Uchi, Motoaki Shiratsuchi, Masutaka Furue, Masatoshi Nomura, Yoshihiro Ogawa

    BMC Endocrine Disorders   18 ( 1 )   2018.6

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    DOI: 10.1186/s12902-018-0267-x

  • Recovery technique using a double scope to rescue failed primary endoscopic ligation Reviewed

    Yosuke Minoda, Keishi Komori, Ryoko Naruo, Tsutomu Iwasa, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa

    Endoscopy   50 ( 9 )   E244 - E245   2018.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1055/a-0631-7760

  • Using CRISPR/Cas9 to knock out amylase in acinar cells decreases pancreatitis-induced autophagy. Reviewed International journal

    K. Yasunaga, T. Ito, M. Miki, K. Ueda, T. Fujiyama, Y. Tachibana, N. Fujimori, K. Kawabe and Y. Ogawa.

    Biomed Res Int.   17   8719397   2018.5

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    DOI: 10.1155/2018/8719397.

  • Relapse patterns and predictors of IgG4-related diseases involved with autoimmune pancreatitis: A single-center retrospective study of 115 patients. Reviewed International journal

    M. Miki, N. Fujimori, T. Oono, K. Kawabe, A. Ohno, K. Matsumoto, K. Teramatsu, Y. Tachibana and Y. Ogawa.

    J Dig Dis.   30 ( 3 )   152 - 158   2018.5

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    DOI: 10.1111/1751-2980.12708.

  • Anti-ganglionic acetylcholine receptor antibodies in Japanese patients with motility disorders. Reviewed International journal

    A. Mukaino, H. Minami, H. Isomoto, H. Hamamoto, E. Ihara. Y. Maeda, O. Higuchi, T. Okanishi, Y. Kokudo, K. Deguchi, F. Sasaki, T. Ueki, K. Murata, T. Yoshida, M. Kinjo, Y. Ogawa, A. Ido, H. Matsuo, K. Nakao, S. Nakane.

    J Gastroenterol   53 ( 12 )   1227 - 1240   2018.5

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    DOI: 10.1007/s00535-018-1477-8.

  • The occurrence of apparent bilateral aldosterone suppression in adrenal vein sampling for primary aldosteronism Reviewed

    Yui Shibayama, Norio Wada, Mitsuhide Naruse, Isao Kurihara, Hiroshi Ito, Takashi Yoneda, Yoshiyu Takeda, Hironobu Umakoshi, Mika Tsuiki, Takamasa Ichijo, Hisashi Fukuda, Takuyuki Katabami, Takanobu Yoshimoto, Yoshihiro Ogawa, Junji Kawashima, Yuichi Ohno, Masakatsu Sone, Megumi Fujita, Katsutoshi Takahashi, Hirotaka Shibata, Kohei Kamemura, Yuichi Fujii, Koichi Yamamoto, Tomoko Suzuki

    Journal of the Endocrine Society   2 ( 5 )   398 - 407   2018.5

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    DOI: 10.1210/js.2017-00481

  • Fatty Acid Binding Protein 4 (FABP4) Overexpression in Intratumoral Hepatic Stellate Cells within Hepatocellular Carcinoma with Metabolic Risk Factors Reviewed

    Norimichi Chiyonobu, Shu Shimada, Yoshimitsu Akiyama, Kaoru Mogushi, Michiko Itoh, Keiichi Akahoshi, Satoshi Matsumura, Kosuke Ogawa, Hiroaki Ono, Yusuke Mitsunori, Daisuke Ban, Atsushi Kudo, Shigeki Arii, Takayoshi Suganami, Shoji Yamaoka, Yoshihiro Ogawa, Minoru Tanabe, Shinji Tanaka

    American Journal of Pathology   188 ( 5 )   1213 - 1224   2018.5

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    DOI: 10.1016/j.ajpath.2018.01.012

  • Dietary inflammatory index and risk of upper aerodigestive tract cancer in Japanese adults Reviewed

    Makiko Abe, Nitin Shivappa, Hidemi Ito, Isao Oze, Tetsuya Abe, Yasuhiro Shimizu, Yasuhisa Hasegawa, Chikako Kiyohara, Masatoshi Nomura, Yoshihiro Ogawa, James R. Hebert, Keitaro Matsuo

    Oncotarget   9 ( 35 )   24028 - 24040   2018.5

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    DOI: 10.18632/oncotarget.25288

  • Accuracy of adrenal computed tomography in predicting the unilateral subtype in young patients with hypokalaemia and elevation of aldosterone in primary aldosteronism Reviewed

    , Hironobu Umakoshi, Tatsuki Ogasawara, Yoshiyu Takeda, Isao Kurihara, Hiroshi Itoh, Takuyuki Katabami, Takamasa Ichijo, Norio Wada, Yui Shibayama, Takanobu Yoshimoto, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Katsutoshi Takahashi, Minemori Watanabe, Yuichi Matsuda, Hiroki Kobayashi, Hirotaka Shibata, Kohei Kamemura, Michio Otsuki, Yuichi Fujii, Koichi Yamamto, Atsushi Ogo, Toshihiko Yanase, Shintaro Okamura, Shozo Miyauchi, Tomoko Suzuki, Mika Tsuiki, Mitsuhide Naruse

    Clinical Endocrinology   88 ( 5 )   645 - 651   2018.5

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    DOI: 10.1111/cen.13582

  • Clinicopathogenic and molecular characteristics of synchronous colorectal carcinoma with mismatch repair deficiency. Reviewed International journal

    T. Goto, M. Itoh, T. Suganami, S. Kanai, I. Shirakawa, T. Sakai, M. Asakawa, T. Yoneyama, T. Kai, and Y. Ogawa.

    Sci Rep.   8 ( 1 )   8157   2018.5

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    DOI: 10.1038/s41598-018-26383-8.

  • Sarcopenic obesity assessed using dual energy X-ray absorptiometry (DXA) can predict cardiovascular disease in patients with type 2 diabetes A retrospective observational study Reviewed

    Tatsuya Fukuda, Ryotaro Bouchi, Takato Takeuchi, Kazutaka Tsujimoto, Isao Minami, Takanobu Yoshimoto, Yoshihiro Ogawa

    Cardiovascular Diabetology   17 ( 1 )   2018.4

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    DOI: 10.1186/s12933-018-0700-5

  • JPAS Study Group. Significance of computed tomography and serum potassium in predicting subtype diagnosis of primary aldosteronism. Reviewed International journal

    H. Umakoshi, M. Tsuiki, Y. Takeda, I. Kurihara, H. Itoh, T. Katabami, T. Ichijo, N. Wada, T. Yoshimoto, Y. Ogawa, J. Kawashima, M. Sone, N. Inagaki, K. Takahashi, M. Watanabe, Y. Matsuda, H. Kobayashi, H. Shibata, K. Kamemura, M. Otsuki, Y. Fujii, K. Yamamto, A. Ogo, T. Yanase, T. Suzuki, M. Naruse,

    J. Clin. Endocrinol. Metab.   103 ( 3 )   900 - 908   2018.3

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    DOI: 10.1210/jc.2017-01774.

  • Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration Reviewed

    Yukino Hatazawa, Yusuke Ono, Yuma Hirose, Sayaka Kanai, Nobuharu L. Fujii, Shuichi Machida, Ichizo Nishino, Takahiko Shimizu, Masaki Okano, Yasutomi Kamei, Yoshihiro Ogawa

    FASEB Journal   32 ( 3 )   1452 - 1467   2018.3

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    DOI: 10.1096/fj.201700573R

  • Ratio of visceral-to-subcutaneous fat area predicts cardiovascular events in patients with type 2 diabetes Reviewed

    Tatsuya Fukuda, Ryotaro Bouchi, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa

    Journal of Diabetes Investigation   9 ( 2 )   396 - 402   2018.3

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    DOI: 10.1111/jdi.12713

  • Molecular mechanism of obesity-induced ‘metabolic’ tissue remodeling Reviewed

    9 ( 2 )   256 - 261   2018.3

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    Chronic inflammation is a common molecular basis underlying a variety of chronic diseases. Accumulating evidence has also suggested that chronic inflammation contributes to the pathogenesis of obesity and diabetes, which have been considered as metabolic diseases. For the past several decades, there has been dramatic progress in understanding the underlying mechanism of adipose tissue dysfunction induced by obesity. Tissue remodeling is one of the histological features of chronic inflammation, in which stromal cells dramatically change in number and cell type. Indeed, adipose tissue remodeling is induced by various stromal cells, and results in the impairment of adipose tissue function, such as adipocytokine production and lipid storage, which leads to systemic metabolic disorder. In addition to adipose tissue, the liver is another example of obesity-induced tissue remodeling. In the present review, we discuss how obesity induces interstitial fibrosis in adipose tissue and the liver, particularly focusing on the role of macrophages.

    DOI: 10.1111/jdi.12769

  • Mild Maternal Hypothyroxinemia during Pregnancy Induces Persistent DNA Hypermethylation in the Hippocampal Brain-Derived Neurotrophic Factor Gene in Mouse Offspring Reviewed

    Kenichi Kawahori, Koshi Hashimoto, Xunmei Yuan, Kazutaka Tsujimoto, Nozomi Hanzawa, Miho Hamaguchi, Saori Kase, Kyota Fujita, Kazuhiko Tagawa, Hitoshi Okazawa, Yasuyo Nakajima, Nobuyuki Shibusawa, Masanobu Yamada, Yoshihiro Ogawa

    Thyroid   28 ( 3 )   395 - 406   2018.3

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    DOI: 10.1089/thy.2017.0331

  • Endogenous Hydrogen Sulfide Contributes to Tone Generation in Porcine Lower Esophageal Sphincter Via Na+/Ca2+ Exchanger Reviewed

    Xiaopeng Bai, Eikichi Ihara, Katsuya Hirano, Yoshimasa Tanaka, Kayoko Nakano, Satomi Kita, Takahiro Iwamoto, Haruei Ogino, Mayumi Hirano, Yoshinao Oda, Kazuhiko Nakamura, Yoshihiro Ogawa

    CMGH   5 ( 3 )   209 - 221   2018.3

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    DOI: 10.1016/j.jcmgh.2017.11.004

  • p66Shc signaling mediates diabetes-related cognitive decline. Reviewed International journal

    Y. Minami, N. Sonoda, E. Hayashida, H. Makimura, M. Ide, N. Ikeda, M. Ohgidani, T.A. Kato, Y. Seki, Y. Maeda, S. Kanba, R. Takayanagi, Y. Ogawa, and T. Inoguchi.

    Sci. Rep.   8   e3213   2018.2

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    DOI: 10.1038/s41598-018-21426-6.

  • Splash M-knife versus Flush Knife BT in the technical outcomes of endoscopic submucosal dissection for early gastric cancer A propensity score matching analysis Reviewed

    Mitsuru Esaki, Sho Suzuki, Yasuyo Hayashi, Azusa Yokoyama, Shuichi Abe, Taizo Hosokawa, Haruei Ogino, Hirotada Akiho, Eikichi Ihara, Yoshihiro Ogawa

    BMC Gastroenterology   18 ( 1 )   2018.2

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    DOI: 10.1186/s12876-018-0763-5

  • Serum Bilirubin Concentration is Associated with Left Ventricular Remodeling in Patients with Type 2 Diabetes Mellitus A Cohort Study Reviewed

    Tomoaki Inoue, Noriyuki Sonoda, Shinsuke Hiramatsu, Shinichiro Kimura, Yoshihiro Ogawa, Toyoshi Inoguchi

    Diabetes Therapy   9 ( 1 )   331 - 338   2018.2

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    DOI: 10.1007/s13300-018-0368-6

  • Dipeptidyl peptidase 4 inhibitors attenuates the decline of skeletal muscle mass in patients with type 2 diabetes Reviewed

    Ryotaro Bouchi, Tatsuya Fukuda, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa

    Diabetes/Metabolism Research and Reviews   34 ( 2 )   2018.2

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    DOI: 10.1002/dmrr.2957

  • FABP4 overexpressed in intratumoral hepatic stellate cells within hepatocellular carcinoma with metabolic risk factors. Invited Reviewed International journal

    N. Chiyonobu, S. Shimada, Y. Akiyama, K. Mogushi, M. Itoh, K. Akahoshi, S. Matsumura, K. Ogawa, H. Ono, Y. Mitsunori, D. Ban, A. Kudo, S. Arii, T. Suganami, S. Yamaoka, Y. Ogawa, M. Tanabe, and S. Tanaka.

    Am. J. Pathol.   188   1213 - 1224   2018.2

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    DOI: 10.1016/j.ajpath.

  • Dose and schedule modification are required for long-term continuation of sunitinib in Japanese patients with advanced pancreatic neuroendocrine tumors. Reviewed International journal

    L. Lee , T. Ito, H. Igarashi, M. Miki, N. Fujimori, K. Kawabe, RT Jensen, Y. Ogawa.

    Cancer Chemother Pharmacol.   81 ( 1 )   163 - 169   2018.1

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    DOI: 10.1007/s00280-017-3482-7.

  • Sialic Acid-Binding Immunoglobulin-Like Lectin1 as a Novel Predictive Biomarker for Relapse in Graves' Disease A Multicenter Study Reviewed

    Koshi Hashimoto, Eijun Nishihara, Masako Matsumoto, Shunichi Matsumoto, Yasuyo Nakajima, Kazutaka Tsujimoto, Hajime Yamakage, Noriko Satoh-Asahara, Jaeduk Yoshimura Noh, Koichi Ito, Akira Miyauchi, Masatomo Mori, Masanobu Yamada, Yoshihiro Ogawa

    Thyroid : official journal of the American Thyroid Association   28 ( 1 )   50 - 59   2018.1

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    DOI: 10.1089/thy.2017.0244

  • Obesity and abnormal glucose tolerance in offspring of diabetic mothers A systematic review and meta-analysis Reviewed

    Maki Kawasaki, Naoko Arata, Celine Miyazaki, Rintaro Mori, Toru Kikuchi, Yoshihiro Ogawa, Erika Ota

    PloS one   13 ( 1 )   2018.1

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    DOI: 10.1371/journal.pone.0190676

  • Effectiveness of nationwide screening and lifestyle intervention for abdominal obesity and cardiometabolic risks in Japan The metabolic syndrome and comprehensive lifestyle intervention study on nationwide database in Japan (MetS ACTION-J study) Reviewed

    Yoko M. Nakao, Yoshihiro Miyamoto, Kenji Ueshima, Kazuhiro Nakao, Michikazu Nakai, Kunihiro Nishimura, Shinji Yasuno, Kiminori Hosoda, Yoshihiro Ogawa, Hiroshi Itoh, Hisao Ogawa, Kenji Kangawa, Kazuwa Nakao

    PloS one   13 ( 1 )   2018.1

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    DOI: 10.1371/journal.pone.0190862

  • Dose and schedule modification are required for long-term continuation of sunitinib in Japanese patients with advanced pancreatic neuroendocrine tumors Reviewed

    Lingaku Lee, Tetsuhide Ito, Hisato Igarashi, Masami Miki, Nao Fujimori, Ken Kawabe, Robert T. Jensen, Yoshihiro Ogawa

    Cancer chemotherapy and pharmacology   81 ( 1 )   163 - 169   2018.1

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    DOI: 10.1007/s00280-017-3482-7

  • A case of non-cardiac chest pain caused by esophageal motility disorder observed on esophageal high-resolution manometry Reviewed

    Kazumasa Muta, Eikichi Ihara, Yusuke Kitagawa, Shohei Hamada, Keita Fukaura, Tsutomu Iwasa, Akira Aso, Haruei Ogino, Kazuhiko Nakamura, Yoshihiro Ogawa

    Journal of Japanese Society of Gastroenterology   115 ( 4 )   401 - 408   2018.1

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    DOI: 10.11405/nisshoshi.115.401

  • An advanced well-differentiated pancreatic neuroendocrine carcinoma (NET-G3) associated with von hippel-lindau disease Reviewed

    Masami Miki, Ken Kawabe, Hisato Igarashi, Tatsuro Abe, Yoshihiro Ohishi, Risa Hashimoto, Takashi Karashima, Ichiro Yamasaki, Keiji Inoue, Tetsuhide Ito, Yoshihiro Ogawa

    Internal Medicine   57 ( 14 )   2007 - 2011   2018

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    DOI: 10.2169/internalmedicine.0416-17

  • Using CRISPR/Cas9 to Knock out Amylase in Acinar Cells Decreases Pancreatitis-Induced Autophagy Reviewed

    Kohei Yasunaga, Tetsuhide Ito, Masami Miki, Keijiro Ueda, Takashi Fujiyama, Yuichi Tachibana, Nao Fujimori, Ken Kawabe, Yoshihiro Ogawa

    BioMed Research International   2018   2018

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    DOI: 10.1155/2018/8719397

  • Significance of computed tomography and serum potassium in predicting subtype diagnosis of primary aldosteronism Reviewed

    Hironobu Umakoshi, Mika Tsuiki, Yoshiyu Takeda, Isao Kurihara, Hiroshi Itoh, Takuyuki Katabami, Takamasa Ichijo, Norio Wada, Takanobu Yoshimoto, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Katsutoshi Takahashi, Minemori Watanabe, Yuichi Matsuda, Hiroki Kobayashi, Hirotaka Shibata, Kohei Kamemura, Michio Otsuki, Yuichi Fujii, Koichi Yamamto, Atsushi Ogo, Toshihiko Yanase, Tomoko Suzuki, Mitsuhide Naruse, Study Group JPAS Study Group

    Journal of Clinical Endocrinology and Metabolism   103 ( 3 )   900 - 908   2018

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    DOI: 10.1210/jc.2017-01774

  • Repeated hypoglycemic episodes with postprandial hyperinsulinemia after the recovery from acute weight loss revealed by continuous glucose monitoring and the oral glucose tolerance test Reviewed

    Seizaburo Masuda, Masanori Murakami, Ryotaro Bouchi, Isao Minami, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa

    Internal Medicine   57 ( 5 )   697 - 700   2018

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    DOI: 10.2169/internalmedicine.9452-17

  • Prevalence of Cardiovascular Disease and Its Risk Factors in Primary Aldosteronism A Multicenter Study in Japan Reviewed

    , Youichi Ohno, Masakatsu Sone, Nobuya Inagaki, Toshinari Yamasaki, Osamu Ogawa, Yoshiyu Takeda, Isao Kurihara, Hiroshi Itoh, Hironobu Umakoshi, Mika Tsuiki, Takamasa Ichijo, Takuyuki Katabami, Yasushi Tanaka, Norio Wada, Yui Shibayama, Takanobu Yoshimoto, Yoshihiro Ogawa, Junji Kawashima, Katsutoshi Takahashi, Megumi Fujita, Minemori Watanabe, Yuichi Matsuda, Hiroki Kobayashi, Hirotaka Shibata, Kohei Kamemura, Michio Otsuki, Yuichi Fujii, Koichi Yamamoto, Atsushi Ogo, Shintaro Okamura, Shozo Miyauchi, Tomikazu Fukuoka, Shoichiro Izawa, Takashi Yoneda, Shigeatsu Hashimoto, Toshihiko Yanase, Tomoko Suzuki, Takashi Kawamura, Yasuharu Tabara, Fumihiko Matsuda, Mitsuhide Naruse

    Hypertension   71 ( 3 )   530 - 537   2018

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    DOI: 10.1161/HYPERTENSIONAHA.117.10263

  • Obesity as a key factor underlying idiopathic hyperaldosteronism Reviewed

    , Youichi Ohno, Masakatsu Sone, Nobuya Inagaki, Toshinari Yamasaki, Osamu Ogawa, Yoshiyu Takeda, Isao Kurihara, Hironobu Umakoshi, Takamasa Ichijo, Takuyuki Katabami, Norio Wada, Yoshihiro Ogawa, Takanobu Yoshimoto, Junji Kawashima, Minemori Watanabe, Yuichi Matsuda, Hiroki Kobayashi, Hirotaka Shibata, Shozo Miyauchi, Kohei Kamemura, Tomikazu Fukuoka, Koichi Yamamoto, Michio Otsuki, Tomoko Suzuki, Mitsuhide Naruse

    Journal of Clinical Endocrinology and Metabolism   103 ( 12 )   4456 - 4464   2018

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    DOI: 10.1210/jc.2018-00866

  • Obesity and abnormal glucose tolerance in the offspring of mothers with diabetes Reviewed

    Maki Kawasaki, Naoko Arata, Yoshihiro Ogawa

    Current Opinion in Obstetrics and Gynecology   30 ( 6 )   361 - 368   2018

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    DOI: 10.1097/GCO.0000000000000479

  • Fatal disseminated tuberculosis during treatment with ruxolitinib plus prednisolone in a patient with primary myelofibrosis A case report and review of the literature Reviewed

    Yasuhiro Tsukamoto, Junichi Kiyasu, Mariko Tsuda, Motohiko Ikeda, Motoaki Shiratsuchi, Yoshihiro Ogawa, Yuji Yufu

    Internal Medicine   57 ( 9 )   1297 - 1300   2018

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    DOI: 10.2169/internalmedicine.9165-17

  • Epigenetic switching and neonatal nutritional environment

    Koshi Hashimoto, Yoshihiro Ogawa

    Advances in Experimental Medicine and Biology   19 - 25   2018

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    DOI: 10.1007/978-981-10-5526-3_3

  • Effect of eplerenone on the glomerular filtration rate (GFR) in primary aldosteronism Sequential changes in the GFR during preoperative eplerenone treatment to subsequent adrenalectomy Reviewed

    Yujiro Nakano, Takanobu Yoshimoto, Tatsuya Fukuda, Masanori Murakami, Ryotaro Bouchi, Isao Minami, Koshi Hashimoto, Yasuhisa Fujii, Kazunori Kihara, Yoshihiro Ogawa

    Internal Medicine   57 ( 17 )   2459 - 2466   2018

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    DOI: 10.2169/internalmedicine.0438-17

  • Development and validation of subtype prediction scores for the workup of primary aldosteronism Reviewed

    , Hiroki Kobayashi, Masanori Abe, Masayoshi Soma, Yoshiyu Takeda, Isao Kurihara, Hiroshi Itoh, Hironobu Umakoshi, Mika Tsuiki, Takuyuki Katabami, Takamasa Ichijo, Norio Wada, Takanobu Yoshimoto, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Katsutoshi Takahashi, Minemori Watanabe, Yuichi Matsuda, Hirotaka Shibata, Kohei Kamemura, Toshihiko Yanase, Michio Otsuki, Yuichi Fujii, Koichi Yamamoto, Atsushi Ogo, Kazutaka Nanba, Akiyo Tanabe, Tomoko Suzuki, Mitsuhide Naruse

    Journal of hypertension   36 ( 11 )   2269 - 2276   2018

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    DOI: 10.1097/HJH.0000000000001855

  • Clinicopathologic and molecular characteristics of synchronous colorectal carcinoma with mismatch repair deficiency Reviewed

    Kayoko Nakano, Hidetaka Yamamoto, Minako Fujiwara, Yutaka Koga, Shinichi Tsuruta, Eikichi Ihara, Eiji Oki, Masafumi Nakamura, Yoshihiro Ogawa, Yoshinao Oda

    American Journal of Surgical Pathology   42 ( 2 )   172 - 182   2018

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    DOI: 10.1097/PAS.0000000000000947

  • Molecular mechanisms of insulin resistance in 2 cases of primary insulin receptor defect-associated diseases Reviewed

    Atsumi Tsuji-Hosokawa, Kei Takasawa, Risa Nomura, Yuichi Miyakawa, Chikahiko Numakura, Atsushi Hijikata, Tsuyoshi Shirai, Yoshihiro Ogawa, Kenichi Kashimada, Tomohiro Morio

    Pediatric Diabetes   18 ( 8 )   917 - 924   2017.12

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    DOI: 10.1111/pedi.12508

  • Biochemical Gas Sensors (Biosniffers) Using Forward and Reverse Reactions of Secondary Alcohol Dehydrogenase for Breath Isopropanol and Acetone as Potential Volatile Biomarkers of Diabetes Mellitus Reviewed

    Po Jen Chien, Takuma Suzuki, Masato Tsujii, Ming Ye, Isao Minami, Kanako Toda, Hiromi Otsuka, Koji Toma, Takahiro Arakawa, Kouji Araki, Yasuhiko Iwasaki, Kayoko Shinada, Yoshihiro Ogawa, Kohji Mitsubayashi

    Analytical chemistry   89 ( 22 )   12261 - 12268   2017.11

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    DOI: 10.1021/acs.analchem.7b03191

  • Sarcopenia is associated with incident albuminuria in patients with type 2 diabetes A retrospective observational study Reviewed

    Ryotaro Bouchi, Tatsuya Fukuda, Takato Takeuchi, Isao Minami, Takanobu Yoshimoto, Yoshihiro Ogawa

    Journal of Diabetes Investigation   8 ( 6 )   783 - 787   2017.11

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    DOI: 10.1111/jdi.12636

  • Loss of skeletal muscle mass and its predictors in type 2 diabetes patients under a multifaceted treatment approach Reviewed

    Norihiko Ohara, Isao Minami, Ryotaro Bouchi, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa

    Diabetology International   8 ( 4 )   366 - 374   2017.11

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    DOI: 10.1007/s13340-017-0325-z

  • Forkhead box class O family member proteins The biology and pathophysiological roles in diabetes Reviewed

    Kyoichiro Tsuchiya, Yoshihiro Ogawa

    Journal of Diabetes Investigation   8 ( 6 )   726 - 734   2017.11

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    DOI: 10.1111/jdi.12651

  • Combined primary hepatic neuroendocrine carcinoma and hepatocellular carcinoma with aggressive biological behavior (adverse clinical course) A case report Reviewed

    Yukihiko Okumura, Kenichi Kohashi, Huanlin Wang, Masaki Kato, Yoshihiko Maehara, Yoshihiro Ogawa, Yoshinao Oda

    Pathology Research and Practice   213 ( 10 )   1322 - 1326   2017.10

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    DOI: 10.1016/j.prp.2017.06.001

  • Regulation of expression and trafficking of perforin-2 by LPS and TNF-α Reviewed

    320   1 - 10   2017.10

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    Perforin-2 is constitutively expressed in macrophages that are required for bacterial control. In this study, we found that perforin-2 is expressed in human macrophages with two isoforms: full-length perforin-2a and a splice variant, perforin-2b. Two isoforms show different subcellular distributions. Perforin-2a was predominantly localized to the membrane of endosome-like vesicles by a C-terminal transmembrane domain. In contrast, the short isoform perforin-2b lacking the transmembrane domain failed to localize to the membrane of vesicles. Furthermore, we determined that the pro-inflammatory stimuli LPS and TNF-α induced perforin-2a expression via the NF-κB pathway and triggered perforin-2a vesicles fusion with lysosomes. On the other hand, we detected the secretion of perforin-2b in response to LPS stimulation. Taken together, our data provide the evidence that membrane-bound and secretory isoforms of perforin-2 are present in human macrophages and may play important roles in immune defense.

    DOI: 10.1016/j.cellimm.2017.07.001

  • Molecular characteristics of the KCNJ5 mutated aldosterone-producing adenomas Reviewed

    Masanori Murakami, Takanobu Yoshimoto, Kazuhiko Nakabayashi, Yujiro Nakano, Takahiro Fukaishi, Kyoichiro Tsuchiya, Isao Minami, Ryotaro Bouchi, Kohji Okamura, Yasuhisa Fujii, Koshi Hashimoto, Ken Ichiro Hata, Kazunori Kihara, Yoshihiro Ogawa

    Endocrine-Related Cancer   24 ( 10 )   531 - 541   2017.10

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    DOI: 10.1530/ERC-17-0117

  • Ipragliflozin Reduces Epicardial Fat Accumulation in Non-Obese Type 2 Diabetic Patients with Visceral Obesity A Pilot Study Reviewed

    Tatsuya Fukuda, Ryotaro Bouchi, Masahiro Terashima, Yuriko Sasahara, Masahiro Asakawa, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa

    Diabetes Therapy   8 ( 4 )   851 - 861   2017.8

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    DOI: 10.1007/s13300-017-0279-y

  • Insulin Treatment Attenuates Decline of Muscle Mass in Japanese Patients with Type 2 Diabetes Reviewed

    Ryotaro Bouchi, Tatsuya Fukuda, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa

    Calcified Tissue International   101 ( 1 )   2017.7

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    DOI: 10.1007/s00223-017-0251-x

  • Association of sarcopenia with both latent autoimmune diabetes in adults and type 2 diabetes A cross-sectional study Reviewed

    Ryotaro Bouchi, Tatsuya Fukuda, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa

    Journal of Diabetes and Its Complications   31 ( 6 )   992 - 996   2017.6

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    DOI: 10.1016/j.jdiacomp.2017.02.021

  • Utility of chromogranin B compared with chromogranin A as a biomarker in Japanese patients with pancreatic neuroendocrine tumors Reviewed

    Masami Miki, Tetsuhide Ito, Masayuki Hijioka, Lingaku Lee, Kohei Yasunaga, Keijiro Ueda, Takashi Fujiyama, Yuichi Tachibana, Ken Kawabe, Robert T. Jensen, Yoshihiro Ogawa

    Japanese journal of clinical oncology   47 ( 6 )   520 - 528   2017.6

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    DOI: 10.1093/jjco/hyx032

  • Association of diabetic retinopathy with both sarcopenia and muscle quality in patients with type 2 diabetes A crosssectional study Reviewed

    Tatsuya Fukuda, Ryotaro Bouchi, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa

    BMJ Open Diabetes Research and Care   5 ( 1 )   2017.5

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    DOI: 10.1136/bmjdrc-2017-000404

  • Serum levels of Wisteria floribunda agglutinin-positive Mac-2 binding protein reflect the severity of chronic pancreatitis Reviewed

    Takashi Fujiyama, Tetsuhide Ito, Keijiro Ueda, Yuichi Tachibana, Kohei Yasunaga, Masami Miki, Takehiro Takaoka, Lingaku Lee, Ken Kawabe, Yoshihiro Ogawa

    Journal of Digestive Diseases   18 ( 5 )   302 - 308   2017.5

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    DOI: 10.1111/1751-2980.12475

  • Achievement of disease control with donor-derived EB virus-specific cytotoxic T cells after allogeneic peripheral blood stem cell transplantation for aggressive NK-cell leukemia Reviewed

    Shojiro Haji, Motoaki Shiratsuchi, Takamitsu Matsushima, Akiko Takamatsu, Mariko Tsuda, Yasuhiro Tsukamoto, Emi Tanaka, Hirofumi Ohno, Eriko Fujioka, Yuriko Ishikawa, Ken Ichi Imadome, Yoshihiro Ogawa

    International journal of hematology   105 ( 4 )   540 - 544   2017.4

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    DOI: 10.1007/s12185-016-2131-y

  • Mechanistic insights into ectodomain shedding Susceptibility of CADM1 adhesion molecule is determined by alternative splicing and O-glycosylation Reviewed

    Kyoko Shirakabe, Takuya Omura, Yoshio Shibagaki, Emiko Mihara, Keiichi Homma, Yukinari Kato, Akihiko Yoshimura, Yoshinori Murakami, Junichi Takagi, Seisuke Hattori, Yoshihiro Ogawa

    Scientific reports   7   2017.4

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    DOI: 10.1038/srep46174

  • Reduction of visceral fat by liraglutide is associated with ameliorations of hepatic steatosis, albuminuria, and micro-inflammation in type 2 diabetic patients with insulin treatment: a randomized control trial. Reviewed International journal

    Ogawa Yoshihiro

    Endocr. J.   64 ( 3 )   269 - 281   2017.3

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  • Luseogliflozin reduces epicardial fat accumulation in patients with type 2 diabetes A pilot study Reviewed

    Ryotaro Bouchi, Masahiro Terashima, Yuriko Sasahara, Masahiro Asakawa, Tatsuya Fukuda, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa

    Cardiovascular Diabetology   16 ( 1 )   2017.3

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    DOI: 10.1186/s12933-017-0516-8

  • Dopamine-Secreting Paraganglioma in the Retroperitoneum Reviewed

    Yusuke Matsuda, Noriko Kimura, Takanobu Yoshimoto, Yoshihiro Sekiguchi, Junzo Tomoishi, Ichiro Kasahara, Yoshihito Hara, Yoshihiro Ogawa

    Endocrine Pathology   28 ( 1 )   36 - 40   2017.3

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    DOI: 10.1007/s12022-016-9457-0

  • Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis Reviewed

    Chikara Komiya, Miyako Tanaka, Kyoichiro Tsuchiya, Noriko Shimazu, Kentaro Mori, Shunsaku Furuke, Yasutaka Miyachi, Kumiko Shiba, Shinobu Yamaguchi, Kenji Ikeda, Kozue Ochi, Kazuhiko Nakabayashi, Ken Ichiro Hata, Michiko Itoh, Takayoshi Suganami, Yoshihiro Ogawa

    Scientific reports   7   2017.3

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    DOI: 10.1038/srep44754

  • Dopamine-secreting paraganglioma in the retroperitoneum. Reviewed International journal

    Ogawa Yoshihiro

    Endocr. Pathol.   28 ( 1 )   36 - 40   2017.3

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  • Abdominal paraganglioma in a young woman with 1p36 deletion syndrome. Reviewed International journal

    Ogawa Yoshihiro

    Am. J. Med. Genet. Part A.   173 ( 2 )   495 - 500   2017.2

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  • Impact of everolimus on Japanese patients with advanced pancreatic neuroendocrine neoplasms Reviewed

    Lingaku Lee, Tetsuhide Ito, Hisato Igarashi, Keijiro Ueda, Takashi Fujiyama, Ken Kawabe, Yoshihiro Ogawa

    Journal of Hepato-Biliary-Pancreatic Sciences   24 ( 2 )   95 - 102   2017.2

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    DOI: 10.1002/jhbp.418

  • Abdominal paraganglioma in a young woman with 1p36 deletion syndrome Reviewed

    Miki Murakoshi, Kei Takasawa, Masato Nishioka, Masahiro Asakawa, Kenichi Kashimada, Takanobu Yoshimoto, Toshiyuki Yamamoto, Kazuhiro Takekoshi, Yoshihiro Ogawa, Masayuki Shimohira

    American Journal of Medical Genetics, Part A   173 ( 2 )   495 - 500   2017.2

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    DOI: 10.1002/ajmg.a.38020

  • A case of an elderly woman with concurrent pancreatic cancer and slowly progressive type 1 diabetes mellitus Reviewed

    Masaki Tanaka, Ansa Kobayashi, Masahiro Asakawa, Momoko Akihisa, Atsuko Miyake, Mitsunobu Kawamura, Yoshihiro Ogawa

    Journal of the Japan Diabetes Society   60 ( 12 )   806 - 812   2017.1

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    DOI: 10.11213/tonyobyo.60.806

  • Symposium Reviewed

    Yoshihiro Ogawa

    Therapeutic Research   38 ( 1 )   21 - 24   2017.1

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  • Reduction of visceral fat by liraglutide is associated with ameliorations of hepatic steatosis, albuminuria, and micro-inflammation in type 2 diabetic patients with insulin treatment A randomized control trial Reviewed

    Ryotaro Bouchi, Yujiro Nakano, Tatsuya Fukuda, Takato Takeuchi, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa

    Endocrine Journal   64 ( 3 )   269 - 281   2017.1

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    DOI: 10.1507/endocrj.EJ16-0449

  • Molecular analysis of aldosterone-producing adenomas Reviewed

    Masanori Murakami, Takanobu Yoshimoto, Yoshihiro Ogawa

    Japanese Journal of Clinical Chemistry   46 ( 1 )   28 - 33   2017.1

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  • A case of type B insulin resistance syndrome with postprandial hyperglycemia successfully treated with liraglutide Reviewed

    Satoru Uchida, Mina Yamaguchi, Hiromi Hasegawa, Noriaki Ohkiba, Ryotaro Bouchi, Isao Minami, Yoshihiro Ogawa

    Journal of the Japan Diabetes Society   60 ( 3 )   244 - 252   2017.1

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  • A case of diabetes mellitus accompanied by tumor-forming pancreatitis that was difficult to distinguish from pancreatic cancer Reviewed

    Rie Nishitani, Keiko Ashidate, Mitsunobu Kawamura, Yoshihiro Ogawa

    Journal of the Japan Diabetes Society   60 ( 1 )   37 - 41   2017.1

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  • Gender difference in the impact of gynoid and android fat masses on the progression of hepatic steatosis in Japanese patients with type 2 diabetes Reviewed

    Ryotaro Bouchi, Tatsuya Fukuda, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa

    BMC Obesity   4 ( 1 )   2017

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    DOI: 10.1186/s40608-017-0163-3

  • The more from East-Asian, the better Risk prediction of colorectal cancer risk by GWAS-identified SNPs among Japanese Reviewed

    Makiko Abe, Hidemi Ito, Isao Oze, Masatoshi Nomura, Yoshihiro Ogawa, Keitaro Matsuo

    Journal of Cancer Research and Clinical Oncology   143 ( 12 )   2481 - 2492   2017

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    DOI: 10.1007/s00432-017-2505-4

  • Systemic sarcoidosis with thyroid involvement Reviewed

    Hideyuki Okuma, Koshi Hashimoto, Xin Wang, Noriaki Ohkiba, Nozomi Murooka, Norikazu Akizuki, Takeshi Inazawa, Yoshihiro Ogawa

    Internal Medicine   56 ( 16 )   2181 - 2186   2017

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    DOI: 10.2169/internalmedicine.8324-16

  • Suppression of extrapancreatic glucagon by octreotide may reduce the fasting and postprandial glucose levels in a diabetic patient after total pancreatectomy Reviewed

    Hideyuki Okuma, Ryotaro Bouchi, Seizaburo Masuda, Takato Takeuchi, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa

    Internal Medicine   56 ( 22 )   3061 - 3066   2017

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    DOI: 10.2169/internalmedicine.8963-17

  • Should the selective arterial secretagogue injection test for insulinoma localization be evaluated at 60 or 120 seconds? Reviewed

    Keijiro Ueda, Tetsuhide Ito, Ken Kawabe, Lingaku Lee, Takashi Fujiyama, Yuichi Tachibana, Masami Miki, Kohei Yasunaga, Takehiro Takaoka, Akihiro Nishie, Yoshiki Asayama, Robert T. Jensen, Yoshihiro Ogawa

    Internal Medicine   56 ( 22 )   2985 - 2991   2017

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    DOI: 10.2169/internalmedicine.9107-17

  • Optimization of left adrenal vein sampling in primary aldosteronism Coping with asymmetrical cortisol secretion Reviewed

    Mitsuhiro Kishino, Takanobu Yoshimoto, Masashi Nakadate, Yoshiaki Katada, Eiichiro Kanda, Shuichiro Nakaminato, Yukihisa Saida, Yoshihiro Ogawa, Ukihide Tateishi

    Endocrine Journal   64 ( 3 )   347 - 355   2017

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    DOI: 10.1507/endocrj.EJ16-0433

  • Metabolic syndrome and NAFLD/NASH Reviewed

    Yoshihiro Ogawa, Michiko Itoh

    Journal of Japanese Society of Gastroenterology   114 ( 5 )   834 - 838   2017

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  • IgG4-related hypophysitis with subtle hypopituitarism in an elderly diabetic patient Is treatment or observation preferable? Reviewed

    Motoki Kawasaki, Motoyoshi Tsujino, Fuminori Sato, Maya Sakurada, Kenji Nishida, Takayasu Kise, Yuko Hijioka, Mitsugu Ishizawa, Kazuaki Enatsu, Yoshihiro Ogawa

    Internal Medicine   56 ( 20 )   2733 - 2738   2017

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    DOI: 10.2169/internalmedicine.8851-17

  • SF-1 deficiency causes lipid accumulation in Leydig cells via suppression of STAR and CYP11A1. Reviewed International journal

    Ogawa Yoshihiro

    Endocrine   54 ( 2 )   484 - 496   2016.11

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  • SF-1 deficiency causes lipid accumulation in Leydig cells via suppression of STAR and CYP11A1 Reviewed

    Megumi Hatano, Toshiro Migita, Tomokazu Ohishi, Yuichi Shima, Yoshihiro Ogawa, Ken Ichirou Morohashi, Yukihiro Hasegawa, Futoshi Shibasaki

    Endocrine   54 ( 2 )   484 - 496   2016.11

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    DOI: 10.1007/s12020-016-1043-1

  • Molecular Mechanism of Lifestyle-related Diseases See Both the Wood and Trees! Reviewed

    Yoshihiro Ogawa

    Fukuoka igaku zasshi = Hukuoka acta medica   107 ( 11 )   191 - 198   2016.11

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  • Inflammatory responses increase secretion of MD-1 protein. Reviewed International journal

    Ogawa Yoshihiro

    Int. Immunol.   28 ( 10 )   503 - 512   2016.10

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  • Inflammatory responses increase secretion of MD-1 protein Reviewed

    Richard Thomas Jennings, Erdenezaya Odkhuu, Akina Nakashima, Naoko Morita, Toshihiko Kobayashi, Ikuko Yamai, Miyako Tanaka, Takayoshi Suganami, Sanae Haga, Michitaka Ozaki, Yasuharu Watanabe, Yoshinori Nagai, Kiyoshi Takatsu, Takane Kikuchi-Ueda, Isao Ichimonji, Yoshihiro Ogawa, Hidekazu Takagi, Tatsuya Yamazaki, Kensuke Miyake, Sachiko Akashi-Takamura

    International immunology   28 ( 10 )   503 - 512   2016.10

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    DOI: 10.1093/intimm/dxw031

  • Expression of inflammation-related genes in aldosterone-producing adenomas with KCNJ5 mutation. Reviewed International journal

    Ogawa Yoshihiro

    Biochem. Biophys. Res. Commun.   476 ( 4 )   614 - 619   2016.8

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  • Expression of inflammation-related genes in aldosterone-producing adenomas with KCNJ5 mutation Reviewed

    Masanori Murakami, Takanobu Yoshimoto, Yujiro Nakano, Kyoichiro Tsuchiya, Isao Minami, Ryotaro Bouchi, Yasuhisa Fujii, Kazuhiko Nakabayashi, Koshi Hashimoto, Ken ichiro Hata, Kazunori Kihara, Yoshihiro Ogawa

    Biochemical and Biophysical Research Communications   476 ( 4 )   614 - 619   2016.8

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    DOI: 10.1016/j.bbrc.2016.06.007

  • Increased visceral adiposity with normal weight is associated with prevalence of non-alcoholic fatty liver disease in Japanese patients with type 2 diabetes. Reviewed International journal

    Ogawa Yoshihiro

    J. Diabetes. Investig.   7   607 - 614   2016.7

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  • Increased visceral adiposity with normal weight is associated with the prevalence of non-alcoholic fatty liver disease in Japanese patients with type 2 diabetes Reviewed

    Ryotaro Bouchi, Takato Takeuchi, Momoko Akihisa, Norihiko Ohara, Yujiro Nakano, Rie Nishitani, Masanori Murakami, Tatsuya Fukuda, Masamichi Fujita, Isao Minami, Masatomo Mihara, Takanobu Yoshimoto, Yoshihiro Ogawa

    Journal of Diabetes Investigation   7 ( 4 )   607 - 614   2016.7

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    DOI: 10.1111/jdi.12443

  • A case of Cushing's syndrome with multiple adrenocortical adenomas composed of compact cells and clear cells. Reviewed International journal

    Ogawa Yoshihiro

    Endocr. Pathol.   27 ( 2 )   136 - 141   2016.6

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  • The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages Reviewed

    Rumi Hachiya, Takuya Shiihashi, Ibuki Shirakawa, Yorihiro Iwasaki, Yoshihiro Matsumura, Yumiko Oishi, Yukiteru Nakayama, Yoshihiro Miyamoto, Ichiro Manabe, Kozue Ochi, Miyako Tanaka, Nobuhito Goda, Juro Sakai, Takayoshi Suganami, Yoshihiro Ogawa

    Scientific reports   6   2016.6

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    DOI: 10.1038/srep28845

  • MDCK cells expressing constitutively active Yes-associated protein (YAP) undergo apical extrusion depending on neighboring cell status Reviewed

    Takanori Chiba, Erika Ishihara, Norio Miyamura, Rika Narumi, Mihoko Kajita, Yasuyuki Fujita, Akira Suzuki, Yoshihiro Ogawa, Hiroshi Nishina

    Scientific reports   6   2016.6

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    DOI: 10.1038/srep28383

  • A Case of Cushing’s Syndrome with Multiple Adrenocortical Adenomas Composed of Compact Cells and Clear Cells Reviewed

    27 ( 2 )   136 - 141   2016.6

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    A 58-year-old woman was referred to our hospital for Cushingoid features and diagnosed as adrenal Cushing’s syndrome due to a right adrenocortical mass (60 × 55 mm). The mass was composed of three different tumors; the first one was homogeneously lipid-poor neoplasm measuring 20 × 13 mm located at the most dorsal region, the second one was heterogeneous and lipid-rich tumor containing multiple foci of calcification measuring 50 × 32 mm located at the central region, and the last one was heterogeneous harboring dilated and tortuous vessels and lipid-poor one measuring 35 × 18 mm at the most ventral region of the adrenal gland. A right adrenalectomy was subsequently performed by open surgery. Macroscopic and microscopic analyses revealed that all three tumors were adrenocortical adenomas; the first one represents a pigmented adrenocortical adenoma, the second one adrenocortical adenoma associated with degeneration, and the third one adrenocortical adenoma harboring extensive degeneration. Immunohistochemical analysis of the steroidogenic enzymes also revealed that all of the tumors had the capacity of synthesizing cortisol. This is a very rare case of Cushing’s syndrome caused by multiple adrenocortical adenomas including a pigmented adenoma. Immunohistochemical analysis of steroidogenic enzymes contributed to understanding of steroidogenesis in each of these three different adrenocortical adenomas in this case.

    DOI: 10.1007/s12022-016-9423-x

  • Retrograde pyelonephritis and lumbar spondylitis due to Salmonella typhi in a type 2 diabetic patient with neurogenic bladder. Reviewed International journal

    Ogawa Yoshihiro

    J. Diabetes. Investig.   7   436 - 439   2016.5

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  • Retrograde pyelonephritis and lumbar spondylitis as a result of Salmonella typhi in a type 2 diabetes patient with neurogenic bladder Reviewed

    Tatsuya Fukuda, Ryotaro Bouchi, Isao Minami, Norihiko Ohara, Yujiro Nakano, Rie Nishitani, Masanori Murakami, Takato Takeuchi, Momoko Akihisa, Masamichi Fujita, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa

    Journal of Diabetes Investigation   7 ( 3 )   436 - 439   2016.5

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    DOI: 10.1111/jdi.12375

  • Clinical relevance of dual-Energy X-ray absorptiometry (DXA) as a simultaneous evaluation of fatty liver disease and atherosclerosis in patients with type 2 diabetes. Reviewed International journal

    Ogawa Yoshihiro

    Cardiovasc. Diabetol.   15   e64   2016.4

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  • Clinical relevance of dual-energy X-ray absorptiometry (DXA) as a simultaneous evaluation of fatty liver disease and atherosclerosis in patients with type 2 diabetes Reviewed

    Ryotaro Bouchi, Yujiro Nakano, Norihiko Ohara, Takato Takeuchi, Masanori Murakami, Masahiro Asakawa, Yuriko Sasahara, Mitsuyuki Numasawa, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa

    Cardiovascular Diabetology   15 ( 1 )   2016.4

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    DOI: 10.1186/s12933-016-0384-7

  • Indirect measure of visceral adiposity "a body shape index" (ABSI) is associated with arterial stiffness in patients with type 2 diabetes. Reviewed International journal

    Ogawa Yoshihiro

    BMJ Open Diab. Res. Care   4 ( 1 )   e000188   2016.3

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  • Serum free thyroxine levels are associated with the efficacy of weight reduction therapy in obese female patients Reviewed

    Koshi Hashimoto, Tetsuya Tagami, Hajime Yamakage, Kazuya Muranaka, Masashi Tanaka, Shinji Odori, Shigeo Kono, Akira Shimatsu, Yoshihiro Ogawa, Noriko Satoh-Asahara

    Endocrine Journal   63 ( 3 )   221 - 229   2016.3

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    DOI: 10.1507/endocrj.EJ15-0498

  • Lifestyle-related diseases and an inter-organ metabolic network Reviewed

    Yasutaka Miyachi, Kyoichiro Tsuchiya, Yoshihiro Ogawa

    Clinical calcium   26 ( 3 )   392 - 398   2016.3

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  • Ipragliflozin improves hepatic steatosis in obese mice and liver dysfunction in type 2 diabetic patients irrespective of body weight reduction Reviewed

    Chikara Komiya, Kyoichiro Tsuchiya, Kumiko Shiba, Yasutaka Miyachi, Shunsaku Furuke, Noriko Shimazu, Shinobu Yamaguchi, Kazuo Kanno, Yoshihiro Ogawa

    PloS one   11 ( 3 )   2016.3

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    DOI: 10.1371/journal.pone.0151511

  • Ipragliflozin improves hepatic steatosis in obese mice and liver dysfunction in type 2 diabetic patients irrespective of body weight reduction. Reviewed International journal

    Ogawa Yoshihiro

    PLoS ONE   11 ( 3 )   e0151511   2016.3

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  • Serum free thyroxine levels is associated with the efficacy of weight reduction therapy in obese female patients. Invited Reviewed International journal

    Ogawa Yoshihiro

    Endocr. J.   63 ( 3 )   221 - 229   2016.2

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  • Gene expression profiling of white adipose tissue reveals paternal transmission of proneness to obesity Reviewed

    Sumiyo Morita, Kazuhiko Nakabayashi, Tomoko Kawai, Keiko Hayashi, Takuro Horii, Mika Kimura, Yasutomi Kamei, Yoshihiro Ogawa, Kenichiro Hata, Izuho Hatada

    Scientific reports   6   2016.2

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    DOI: 10.1038/srep21693

  • Gene expression profiling of white adipose tissue reveals paternal transmission of proneness to obesity. Reviewed International journal

    Ogawa Yoshihiro

    Sci. Rep.   6   e21693   2016.2

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  • MDCK cells expressing constitutively active Yes-associated protein (YAP) undergo apical extrusion depending on neighboring cell status. Reviewed International journal

    Ogawa Yoshihiro

    Sci. Rep.   6   e28383   2016.1

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  • Is visceral adiposity a modifier for the impact of blood pressure on arterial stiffness and albuminuria in patients with type 2 diabetes? Reviewed

    Ryotaro Bouchi, Norihiko Ohara, Masahiro Asakawa, Yujiro Nakano, Takato Takeuchi, Masanori Murakami, Yuriko Sasahara, Mitsuyuki Numasawa, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa

    Cardiovascular Diabetology   15 ( 1 )   2016.1

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    DOI: 10.1186/s12933-016-0335-3

  • The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory response in macrophages. Reviewed International journal

    Ogawa Yoshihiro

    Sci. Rep.   6   e28845   2016.1

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  • Indirect measure of visceral adiposity ‘A body shape index’ (ABSI) is associated with arterial stiffness in patients with type 2 diabetes Reviewed

    4 ( 1 )   2016

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    Objective: Among indirect measures of visceral adiposity, A Body Shape Index (ABSI), which is defined as waist circumference (WC)/(body mass index (BMI)2/3×height1/2), is unique in that ABSI is positively correlated with visceral adiposity and is supposed to be independent of BMI. ABSI has been also shown to be linearly and positively associated with visceral fat mass and all-cause and cardiovascular disease (CVD) in the general population. It is, however, uncertain whether ABSI could be associated with arterial stiffness in patients with diabetes. Methods: This is a cross-sectional study of 607 patients with type 2 diabetes (mean age 64±12 years; 40.0% female). Visceral fat area (VFA, cm2) and subcutaneous fat area (SFA, cm2) were assessed with a dual-impedance analyzer. In order to estimate the risk for CVD, brachial-ankle pulse wave velocity (baPWV, cm) was used for the assessment of arterial stiffness. Results: ABSI was significantly and positively correlated with VFA (r=0.138, p=0.001) and negatively associated with BMI (r=−0.085, p=0.037). The correlation of z-score for ABSI with VFA remained significant (r=0.170, p<0.001) but not with BMI (r=0.009, p=0.820). ABSI (standardized β 0.095, p=0.043) but not WC (standardized β −0.060, p=0.200) was significantly and positively correlated with baPWV in the multivariate model including BMI as a covariate. Conclusions: ABSI appears to reflect visceral adiposity independently of BMI and to be a substantial marker of arterial stiffening in patients with type 2 diabetes.

    DOI: 10.1136/bmjdrc-2015-000188

  • Obesity, diabetes, and gut microbiome Reviewed

    Yoshihiro Ogawa

    Therapeutic Research   37 ( 4 )   338 - 340   2016

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  • A Novel Somatic Deletion Mutation of ATP2B3 in Aldosterone-Producing Adenoma Reviewed

    Masanori Murakami, Takanobu Yoshimoto, Isao Minami, Ryotaro Bouchi, Kyoichiro Tsuchiya, Koshi Hashimoto, Hajime Izumiyama, Yasuhisa Fujii, Takashi Endo, Takumi Akashi, Koshiro Nishimoto, Kuniaki Mukai, Kazunori Kihara, Yoshihiro Ogawa

    Endocrine Pathology   26 ( 4 )   328 - 333   2015.12

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    DOI: 10.1007/s12022-015-9400-9

  • PGC-1 α -mediated changes in phospholipid profiles of exercise-trained skeletal muscle Reviewed

    56 ( 12 )   2286 - 2296   2015.12

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    Exercise training influences phospholipid fatty acid composition in skeletal muscle and these changes are associated with physiological phenotypes; however, the molecular mechanism of this influence on compositional changes is poorly understood. Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α ), a nuclear receptor coactivator, promotes mitochondrial biogenesis, the fiber-type switch to oxidative fibers, and angiogenesis in skeletal muscle. Because exercise training induces these adaptations, together with increased PGC-1α, PGC-1α may contribute to the exercise-mediated change in phospholipid fatty acid composition. To determine the role of PGC-1α, we performed lipidomic analyses of skeletal muscle from genetically modified mice that overexpress PGC-1α in skeletal muscle or that carry KO alleles of PGC-1α . We found that PGC-1α affected lipid profiles in skeletal muscle and increased several phospholipid species in glycolytic muscle, namely phosphatidylcholine (PC) (18:0/22:6) and phosphatidylethanolamine (PE) (18:0/22:6). We also found that exercise training increased PC (18:0/22:6) and PE (18:0/22:6) in glycolytic muscle and that PGC-1α was required for these alterations. Because phospholipid fatty acid composition influences cell permeability and receptor stability at the cell membrane, these phospholipids may contribute to exercise training-mediated functional changes in the skeletal muscle.

    DOI: 10.1194/jlr.M060533

  • Efficacy and safety of sitagliptin for the treatment of diabetes mellitus complicated by chronic liver injury Reviewed

    Masahiro Asakawa, Hiroshi Mitsui, Momoko Akihisa, Tetsuo Sekine, Yoshihiro Niitsu, Arisa Kobayashi, Atsuko Miyake, Naoaki Hashimoto, Mitsunobu Kawamura, Yoshihiro Ogawa

    SpringerPlus   4 ( 1 )   2015.12

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    DOI: 10.1186/s40064-015-1135-z

  • Undernourishment in utero Primes Hepatic Steatosis in Adult Mice Offspring on an Obesogenic Diet; Involvement of Endoplasmic Reticulum Stress Reviewed

    Keiko Muramatsu-Kato, Hiroaki Itoh, Yukiko Kohmura-Kobayashi, Urmi J. Ferdous, Naoaki Tamura, Chizuko Yaguchi, Toshiyuki Uchida, Kazunao Suzuki, Koshi Hashimoto, Takayoshi Suganami, Yoshihiro Ogawa, Naohiro Kanayama

    Scientific reports   5   2015.11

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    DOI: 10.1038/srep16867

  • High visceral fat with low subcutaneous fat accumulation as a determinant of atherosclerosis in patients with type 2 diabetes Reviewed

    Ryotaro Bouchi, Takato Takeuchi, Momoko Akihisa, Norihiko Ohara, Yujiro Nakano, Rie Nishitani, Masanori Murakami, Tatsuya Fukuda, Masamichi Fujita, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa

    Cardiovascular Diabetology   14 ( 1 )   2015.10

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    DOI: 10.1186/s12933-015-0302-4

  • Epidemiology of anorexia nervosa in Japanese adolescents Reviewed

    Mari Hotta, Reiko Horikawa, Hiroyo Mabe, Shin Yokoyama, Eiko Sugiyama, Tadato Yonekawa, Masamitsu Nakazato, Yuri Okamoto, Chisato Ohara, Yoshihiro Ogawa

    BioPsychoSocial Medicine   9 ( 1 )   2015.8

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    DOI: 10.1186/s13030-015-0044-2

  • Integration of transcriptome and methylome analysis of aldosterone-producing adenomas Reviewed

    Masanori Murakami, Takanobu Yoshimoto, Kazuhiko Nakabayashi, Kyoichiro Tsuchiya, Isao Minami, Ryotaro Bouchi, Hajime Izumiyama, Yasuhisa Fujii, Kosei Abe, Chiharu Tayama, Koshi Hashimoto, Takayoshi Suganami, Ken Ichiro Hata, Kazunori Kihara, Yoshihiro Ogawa

    European Journal of Endocrinology   173 ( 2 )   185 - 195   2015.8

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    DOI: 10.1530/EJE-15-0148

  • Metabolomic analysis of the skeletal muscle mice overexpressing PGC-1α Reviewed

    10 ( 6 )   2015.6

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    Peroxisome proliferator-activated receptor (PPAR) γ coactivator 1α (PGC-1α) is a coactivator of various nuclear receptors and other transcription factors whose expression increases in the skeletal muscle during exercise. We have previously made transgenic mice overexpressing PGC-1α in the skeletal muscle (PGC-1α-Tg mice). PGC-1α upregulates the expression of genes associated with red fibers, mitochondrial function, fatty acid oxidation, and branched chain amino acid (BCAA) degradation. However, global analyses of the actual metabolic products have not been investigated. In this study, we conducted metabolomic analysis of the skeletal muscle in PGC-1α-Tg mice by capillary electrophoresis with electrospray ionization time-of-flight mass spectrometry. Principal component analysis and hierarchical cluster analysis showed clearly distinguishable changes in the metabolites between PGC-1α-Tg and wild-type control mice. Changes were observed in metabolite levels of various metabolic pathways such as the TCA cycle, pentose phosphate pathway, nucleotide synthesis, purine nucleotide cycle, and amino acid metabolism, including BCAA and β-alanine. Namely, metabolic products of the TCA cycle increased in PGC-1α-Tg mice, with increased levels of citrate (2.3-fold), succinate (2.2-fold), fumarate (2.8-fold), and malate (2.3-fold) observed. Metabolic products associated with the pentose phosphate pathway and nucleotide biosynthesis also increased in PGC-1α-Tg mice. Meanwhile, BCAA levels decreased (Val, 0.7-fold; Leu, 0.8-fold; and Ile, 0.7-fold), and Glu (3.1-fold) and Asp (2.2-fold) levels increased. Levels of β-alanine and related metabolites were markedly decreased in PGC-1α-Tg mice. Coordinated regulation of the TCA cycle and amino acid metabolism, including BCAA, suggests that PGC-1α plays important roles in energy metabolism. Moreover, our metabolomics data showing the activation of the purine nucleotide pathway, malate-aspartate shuttle, as well as creatine metabolism, which are known to be active during exercise, further suggests that PGC-1α regulates metabolism in exercise. Thus, we demonstrated the roles of PGC-1α in the skeletal muscle at the metabolite level.

    DOI: 10.1371/journal.pone.0129084

  • Eicosapentaenoic acid ameliorates non-alcoholic steatohepatitis in a novel mouse model using melanocortin 4 receptor-deficient mice Reviewed

    Kuniha Konuma, Michiko Itoh, Takayoshi Suganami, Sayaka Kanai, Nobutaka Nakagawa, Takeru Sakai, Hiroyuki Kawano, Mitsuko Hara, Soichi Kojima, Yuichi Izumi, Yoshihiro Ogawa

    PloS one   10 ( 3 )   2015.3

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    DOI: 10.1371/journal.pone.0121528

  • Fat/vessel-derived secretory protein (Favine)/CCDC3 is involved in lipid accumulation Reviewed

    Sachiko Kobayashi, Atsunori Fukuhara, Michio Otsuki, Takayoshi Suganami, Yoshihiro Ogawa, Eiichi Morii, Iichiro Shimomura

    Journal of Biological Chemistry   290 ( 12 )   7443 - 7451   2015.3

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    DOI: 10.1074/jbc.M114.592493

  • Difficult medical management in elderly diabetic patients with polypharmacy An analysis of cases accompanied by frequent consciousness loss and asymptomatic hypoglycemia Reviewed

    Masahiro Asakawa, Tetsuo Sekine, Yoshihiro Niitsu, Arisa Kobayashi, Atsuko Miyake, Mitsunobu Kawamura, Yoshihiro Ogawa

    Journal of the Japan Diabetes Society   58 ( 9 )   688 - 694   2015.1

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  • Intestine-targeted DGAT1 inhibition improves obesity and insulin resistance without skin aberrations in mice Reviewed

    Naoto Tsuda, Shin Kumadaki, Chika Higashi, Makoto Ozawa, Mikihiko Shinozaki, Yutaka Kato, Koutarou Hoshida, Satomi Kikuchi, Yoshihisa Nakano, Yoshihiro Ogawa, Shoji Furusako

    PloS one   9 ( 11 )   2014.11

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    DOI: 10.1371/journal.pone.0112027

  • SIK2 is critical in the regulation of lipid homeostasis and adipogenesis in vivo Reviewed

    Jinyoung Park, Young Sil Yoon, Hye Sook Han, Yong Hoon Kim, Yoshihiro Ogawa, Keun Gyu Park, Chul Ho Lee, Seong Tae Kim, Seung Hoi Koo

    Diabetes   63 ( 11 )   3659 - 3673   2014.11

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    DOI: 10.2337/db13-1423

  • FOXO1 activates glutamine synthetase gene in mouse skeletal muscles through a region downstream of 3’-UTR Possible contribution to ammonia detoxification Reviewed

    307 ( 6 )   E485 - E493   2014.9

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    Skeletal mus- cle is a reservoir of energy in the form of protein, which is degraded under catabolic conditions, resulting in the formation of amino acids and ammonia as a byproduct. The expression of FOXO1, a forkhead- type transcription factor, increases during starvation and exercise. In agreement, transgenic FOXO1-Tg mice that overexpress FOXO1 in skeletal muscle exhibit muscle atrophy. The aim of this study was to examine the role of FOXO1 in amino acid metabolism. The mRNA and protein expressions of glutamine synthetase (GS) were increased in skeletal muscle of FOXO1-Tg mice. Fasting induced FOXO1 and GS expression in wild-type mice but hardly increased GS expression in muscle-specific FOXO1 knockout (FOXO1-KO) mice. Activation of FOXO1 also increased GS mRNA and protein expression in C2C12 myoblasts. Using a transient transfection reporter assay, we observed that FOXO1 activated the GS reporter construct. Mutation of a putative FOXO1-binding consensus sequence in the downstream genomic region of GS decreased basal and FOXO1-dependent re- porter activity significantly. A chromatin immunoprecipitation assay showed that FOXO1 was recruited to the 3= region of GS in C2C12 myoblasts. These results suggest that FOXO1 directly upregulates GS expression. GS is considered to mediate ammonia clearance in skel- etal muscle. In agreement, an intravenous ammonia challenge in- creased blood ammonia concentrations to a twofold higher level in FOXO1-KO than in wild-type mice, demonstrating that the capacity for ammonia disposal correlated inversely with the expression of GS in muscle. These data indicate that FOXO1 plays a role in amino acid metabolism during protein degradation in skeletal muscle.

    DOI: 10.1152/ajpendo.00177.2014

  • PGC-1α-mediated branched-chain amino acid metabolism in the skeletal muscle Reviewed

    9 ( 3 )   2014.3

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    Peroxisome proliferator-activated receptor (PPAR) c coactivator 1a (PGC-1α) is a coactivator of various nuclear receptors and other transcription factors, which is involved in the regulation of energy metabolism, thermogenesis, and other biological processes that control phenotypic characteristics of various organ systems including skeletal muscle. PGC-1α in skeletal muscle is considered to be involved in contractile protein function, mitochondrial function, metabolic regulation, intracellular signaling, and transcriptional responses. Branched-chain amino acid (BCAA) metabolism mainly occurs in skeletal muscle mitochondria, and enzymes related to BCAA metabolism are increased by exercise. Using murine skeletal muscle overexpressing PGC-1α and cultured cells, we investigated whether PGC-1α stimulates BCAA metabolism by increasing the expression of enzymes involved in BCAA metabolism. Transgenic mice overexpressing PGC-1α specifically in the skeletal muscle had increased the expression of branched-chain aminotransferase (BCAT) 2, branched-chain a-keto acid dehydrogenase (BCKDH), which catabolize BCAA. The expression of BCKDH kinase (BCKDK), which phosphorylates BCKDH and suppresses its enzymatic activity, was unchanged. The amount of BCAA in the skeletal muscle was significantly decreased in the transgenic mice compared with that in the wild-type mice. The amount of glutamic acid, a metabolite of BCAA catabolism, was increased in the transgenic mice, suggesting the activation of muscle BCAA metabolism by PGC-1α. In C2C12 cells, the overexpression of PGC-1α significantly increased the expression of BCAT2 and BCKDH but not BCKDK. Thus, PGC-1α in the skeletal muscle is considered to significantly contribute to BCAA metabolism. Copyright:

    DOI: 10.1371/journal.pone.0091006

  • Possible involvement of opa-interacting protein 5 in adipose proliferation and obesity Reviewed

    Kana Inoue, Norikazu Maeda, Takuya Mori, Ryohei Sekimoto, Yu Tsushima, Keisuke Matsuda, Masaya Yamaoka, Takayoshi Suganami, Hitoshi Nishizawa, Yoshihiro Ogawa, Tohru Funahashi, Iichiro Shimomura

    PloS one   9 ( 2 )   2014.2

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    DOI: 10.1371/journal.pone.0087661

  • Paternal allele influences high fat diet-induced obesity Reviewed

    Sumiyo Morita, Takuro Horii, Mika Kimura, Yuji Arai, Yasutomi Kamei, Yoshihiro Ogawa, Izuho Hatada

    PloS one   9 ( 1 )   2014.1

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    DOI: 10.1371/journal.pone.0085477

  • A case of type 1 diabetes with frequent hypoglycemic episodes induced by primary hypothyroidism Reviewed

    Masahiro Asakawa, Arisa Niwa, Momoko Akihisa, Mizuho Sawada, Atsuko Miyake, Mitsunobu Kawamura, Yoshihiro Ogawa

    Journal of the Japan Diabetes Society   57 ( 4 )   242 - 248   2014

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  • Vascular complications and coagulation-related changes in the perioperative period in japanese patients undergoing non-cardiac surgery Reviewed

    Chikako Aoyama-Mani, Shoji Kawachi, Yoshihiro Ogawa, Norihiro Kato

    Journal of atherosclerosis and thrombosis   21 ( 5 )   414 - 434   2014

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    DOI: 10.5551/jat.21139

  • An increase in the EPA/AA ratio is associated with improved arterial stiffness in obese patients with dyslipidemia Reviewed

    Ryo Ito, Noriko Satoh-Asahara, Hajime Yamakage, Yousuke Sasaki, Shinji Odori, Shigeo Kono, Hiromichi Wada, Takayoshi Suganami, Yoshihiro Ogawa, Koji Hasegawa, Akira Shimatsu

    Journal of atherosclerosis and thrombosis   21 ( 3 )   248 - 260   2014

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    DOI: 10.5551/jat.19976

  • Hepatic crown-like structure A unique histological feature in non-alcoholic steatohepatitis in mice and humans Reviewed

    Michiko Itoh, Hideaki Kato, Takayoshi Suganami, Kuniha Konuma, Yoshio Marumoto, Shuji Terai, Hiroshi Sakugawa, Sayaka Kanai, Miho Hamaguchi, Takahiro Fukaishi, Seiichiro Aoe, Kazunari Akiyoshi, Yoshihiro Komohara, Motohiro Takeya, Isao Sakaida, Yoshihiro Ogawa

    PloS one   8 ( 12 )   2013.12

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    DOI: 10.1371/journal.pone.0082163

  • A Novel Role for Adipose Ephrin-B1 in Inflammatory Response Reviewed

    Takuya Mori, Norikazu Maeda, Kana Inoue, Ryohei Sekimoto, Yu Tsushima, Keisuke Matsuda, Masaya Yamaoka, Takayoshi Suganami, Hitoshi Nishizawa, Yoshihiro Ogawa, Tohru Funahashi, Iichiro Shimomura

    PloS one   8 ( 10 )   2013.10

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    DOI: 10.1371/journal.pone.0076199

  • FoxO1 inhibits skeletal muscle hypertrophy through mTOR-independent mechanisms Reviewed

    Rachael A. Potter, Alissa D. DeLong, Sierra M. Smith, Benjamin M. Erb, Bryon Renwand, Yasutomi Kamei, Yoshihiro Ogawa, Thomas J. McLoughlin

    Journal of Exercise Physiology Online   16 ( 4 )   32 - 50   2013.9

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  • Association between body weight at weaning and remodeling in the subcutaneous adipose tissue of obese adult mice with undernourishment in utero Reviewed

    Yukiko Kobayashi Kohmura, Naohiro Kanayama, Keiko Muramatsu, Naoaki Tamura, Chizuko Yaguchi, Toshiyuki Uchida, Kazunao Suzuki, Kazuhiro Sugihara, Seiichiro Aoe, Takeshi Sasaki, Takayoshi Suganami, Yoshihiro Ogawa, Hiroaki Itoh

    Reproductive Sciences   20 ( 7 )   813 - 827   2013.7

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    DOI: 10.1177/1933719112466300

  • Efficacy of liraglutide in Japanese patients with type 2 diabetes assessed using continuous glucose monitoring Reviewed

    Fuminori Sato, Motoyoshi Tsujino, Yasutaka Miyachi, Ikue Ishimoto, Yuka Nagata, Chikara Komiya, Takuya Ohashi, Yukiko Kurosawa, Maya Sakurada, Kenji Nishida, Yoshihiro Ogawa

    Journal of the Japan Diabetes Society   56 ( 7 )   430 - 435   2013.7

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  • Analysis of DNA methylation change induced by Dnmt3b in mouse hepatocytes Reviewed

    Mayumi Takahashi, Yasutomi Kamei, Tatsuya Ehara, Xunmei Yuan, Takayoshi Suganami, Takako Takai-Igarashi, Izuho Hatada, Yoshihiro Ogawa

    Biochemical and Biophysical Research Communications   434 ( 4 )   873 - 878   2013.5

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    DOI: 10.1016/j.bbrc.2013.04.041

  • Glucose-independent persistence of PAI-1 gene expression and H3K4 tri-methylation in type 1 diabetic mouse endothelium Implication in metabolic memory Reviewed

    Fumihiko Takizawa, Shuki Mizutani, Yoshihiro Ogawa, Naoki Sawada

    Biochemical and Biophysical Research Communications   433 ( 1 )   66 - 72   2013.3

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    DOI: 10.1016/j.bbrc.2013.02.064

  • Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A Reviewed

    Natsuko Yamakawa, Umeharu Ohto, Sachiko Akashi-Takamura, Koichiro Takahashi, Shin Ichiroh Saitoh, Natsuko Tanimura, Takayoshi Suganami, Yoshihiro Ogawa, Takuma Shibata, Toshiyuki Shimizu, Kensuke Miyake

    International immunology   25 ( 1 )   45 - 52   2013.1

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    DOI: 10.1093/intimm/dxs084

  • [Role of chronic inflammation in adipose tissue in the pathophysiology of obesity]. Reviewed

    Takayoshi Suganami, Yoshihiro Ogawa

    Unknown Journal   71 ( 2 )   225 - 230   2013.1

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  • Hydrogen sulfide increases nitric oxide production with calcium-dependent activation of endothelial nitric oxide synthase in endothelial cells Reviewed

    Michiya Kida, Toru Sugiyama, Takanobu Yoshimoto, Yoshihiro Ogawa

    European Journal of Pharmaceutical Sciences   48 ( 1-2 )   211 - 215   2013.1

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    DOI: 10.1016/j.ejps.2012.11.001

  • Response to Comment on Satoh-Asahara et al. Highly purified eicosapentaenoic acid increases interleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia. Diabetes Care 2012; 35:2631-2639 Reviewed

    Noriko Satoh-Asahara, Akira Shimatsu, Hiromichi Wada, Takayoshi Suganami, Koji Hasegawa, Yoshihiro Ogawa

    Diabetes care   36 ( 7 )   e110   2013

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    DOI: 10.2337/dc13-0376

  • Diurnal expression of Dnmt3b mRNA in mouse liver is regulated by feeding and hepatic clockwork Reviewed

    Fumihiko Maekawa, Shigeki Shimba, Shota Takumi, Tomoharu Sano, Takehiro Suzuki, Jinhua Bao, Mika Ohwada, Tatsuya Ehara, Yoshihiro Ogawa, Keiko Nohara

    Epigenetics   7 ( 9 )   1046 - 1056   2012.9

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    DOI: 10.4161/epi.21539

  • Adipose tissue inflammation and ectopic lipid accumulation Reviewed

    Takayoshi Suganami, Miyako Tanaka, Yoshihiro Ogawa

    Endocrine Journal   59 ( 10 )   849 - 857   2012

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    DOI: 10.1507/endocrj.EJ12-0271

  • Characterization of metabolic phenotypes of mice lacking GPR61, an orphan G-protein coupled receptor Reviewed

    Hirohide Nambu, Miyuki Fukushima, Hirohiko Hikichi, Takao Inoue, Norihiro Nagano, Yoshio Tahara, Tadahiro Nambu, Junko Ito, Yoshihiro Ogawa, Satoshi Ozaki, Hisashi Ohta

    Life Sciences   89 ( 21-22 )   765 - 772   2011.11

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    DOI: 10.1016/j.lfs.2011.09.002

  • Melanocortin 4 receptor-deficient mice as a novel mouse model of nonalcoholic steatohepatitis Reviewed

    Michiko Itoh, Takayoshi Suganami, Nobutaka Nakagawa, Miyako Tanaka, Yukio Yamamoto, Yasutomi Kamei, Shuji Terai, Isao Sakaida, Yoshihiro Ogawa

    American Journal of Pathology   179 ( 5 )   2454 - 2463   2011.11

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    DOI: 10.1016/j.ajpath.2011.07.014

  • The inflammatory changes of adipose tissue in late pregnant mice Reviewed

    Lingyun Zhang, Takashi Sugiyama, Nao Murabayashi, Takashi Umekawa, Ning Ma, Yuki Kamimoto, Yoshihiro Ogawa, Norimasa Sagawa

    Journal of Molecular Endocrinology   47 ( 2 )   157 - 165   2011.10

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    DOI: 10.1530/JME-11-0030

  • Adipose tissue and chronic inflammation Reviewed

    R. Hachiya, T. Suganami, Y. Ogawa

    Journal of the Japan Diabetes Society   54 ( 7 )   480 - 482   2011.7

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  • Role of central Leptin signaling in the starvation-induced alteration of B-cell development Reviewed

    Miyako Tanaka, Takayoshi Suganami, Misa Kim-Saijo, Chitoku Toda, Makoto Tsuiji, Kozue Ochi, Yasutomi Kamei, Yasuhiko Minokoshi, Yoshihiro Ogawa

    Journal of Neuroscience   31 ( 23 )   8373 - 8380   2011.6

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    DOI: 10.1523/JNEUROSCI.6562-10.2011

  • [Obesity Progress in diagnosis and treatment; Topics, IV. Recent topics; 2. Obesity and inflammation]. Reviewed

    Takayoshi Suganami, Yoshihiro Ogawa

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   100 ( 4 )   989 - 995   2011.4

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    DOI: 10.2169/naika.100.989

  • Urinary cystatin C as a potential risk marker for cardiovascular disease and chronic kidney disease in patients with obesity and metabolic syndrome Reviewed

    Noriko Satoh-Asahara, Takayoshi Suganami, Takafumi Majima, Kazuhiko Kotani, Yasuhisa Kato, Rika Araki, Kazunori Koyama, Taiichiro Okajima, Makito Tanabe, Mariko Oishi, Akihiro Himeno, Shigeo Kono, Akira Sugawara, Masakazu Hattori, Yoshihiro Ogawa, Akira Shimatsu

    Clinical Journal of the American Society of Nephrology   6 ( 2 )   265 - 273   2011.2

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    DOI: 10.2215/CJN.04830610

  • [Molecular mechanism of adipose tissue remodeling]. Reviewed

    Naoto Tsuda, Takayoshi Suganami, Yoshihiro Ogawa

    Nihon rinsho. Japanese journal of clinical medicine   69 Suppl 1   279 - 284   2011.1

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  • Increased systemic glucose tolerance with increased muscle glucose uptake in transgenic mice overexpressing RXRγ in skeletal muscle Reviewed

    6 ( 5 )   2011

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    Background: Retinoid X receptor (RXR) γ is a nuclear receptor-type transcription factor expressed mostly in skeletal muscle, and regulated by nutritional conditions. Previously, we established transgenic mice overexpressing RXRγ in skeletal muscle (RXRγ mice), which showed lower blood glucose than the control mice. Here we investigated their glucose metabolism. Methodology/Principal Findings: RXRγ mice were subjected to glucose and insulin tolerance tests, and glucose transporter expression levels, hyperinsulinemic-euglycemic clamp and glucose uptake were analyzed. Microarray and bioinformatics analyses were done. The glucose tolerance test revealed higher glucose disposal in RXRγ mice than in control mice, but insulin tolerance test revealed no difference in the insulin-induced hypoglycemic response. In the hyperinsulinemic-euglycemic clamp study, the basal glucose disposal rate was higher in RXRγ mice than in control mice, indicating an insulin-independent increase in glucose uptake. There was no difference in the rate of glucose infusion needed to maintain euglycemia (glucose infusion rate) between the RXRγ and control mice, which is consistent with the result of the insulin tolerance test. Skeletal muscle from RXRγ mice showed increased Glut1 expression, with increased glucose uptake, in an insulin-independent manner. Moreover, we performed in vivo luciferase reporter analysis using Glut1 promoter (Glut1-Luc). Combination of RXRγ and PPARδ resulted in an increase in Glut1-Luc activity in skeletal muscle in vivo. Microarray data showed that RXRγ overexpression increased a diverse set of genes, including glucose metabolism genes, whose promoter contained putative PPAR-binding motifs. Conclusions/Significance: Systemic glucose metabolism was increased in transgenic mice overexpressing RXRγ. The enhanced glucose tolerance in RXRγ mice may be mediated at least in part by increased Glut1 in skeletal muscle. These results show the importance of skeletal muscle gene regulation in systemic glucose metabolism. Increasing RXRγ expression may be a novel therapeutic strategy against type 2 diabetes.

    DOI: 10.1371/journal.pone.0020467

  • Homeostatic inflammation, an emerging concept Reviewed

    Yoshihiro Ogawa

    Endocrine Journal   57 ( 8 )   657 - 658   2010.10

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    DOI: 10.1507/endocrj.EDT10-08

  • Insulin-induced ectodomain shedding of heparin-binding epidermal growth factor-like growth factor in adipocytes in vitro Reviewed

    Takanobu Yamamoto, Takayoshi Suganami, Minako Kiso-Narita, Peggy A. Scherle, Yasutomi Kamei, Mitsuaki Isobe, Shigeki Higashiyama, Yoshihiro Ogawa

    Obesity   18 ( 10 )   1888 - 1894   2010.10

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    DOI: 10.1038/oby.2010.2

  • A novel glycerophosphodiester phosphodiesterase, GDE5, controls skeletal muscle development via a non-enzymatic mechanism Reviewed

    Journal of Biological Chemistry   285 ( 36 )   27652 - 27663   2010.9

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    DOI: 10.1074/jbc.M110.106708

  • Erratum to Role of transient receptor potential vanilloid 2 in LPS-induced cytokine production in macrophages [Biochem. Biophys. Res. Commun., 398, (2010), 284-289] Reviewed

    Kenji Yamashiro, Tetsuo Sasano, Katsuyoshi Tojo, Iyuki Namekata, Junko Kurokawa, Naoki Sawada, Takayoshi Suganami, Yasutomi Kamei, Hikaru Tanaka, Naoko Tajima, Kazunori Utsunomiya, Yoshihiro Ogawa, Tetsushi Furukawa

    Biochemical and Biophysical Research Communications   400 ( 3 )   2010.9

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    DOI: 10.1016/j.bbrc.2010.08.076

  • Adipose tissue macrophages Their role in adipose tissue remodeling Reviewed

    Takayoshi Suganami, Yoshihiro Ogawa

    Journal of Leukocyte Biology   88 ( 1 )   33 - 39   2010.7

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    DOI: 10.1189/jlb.0210072

  • Role of transient receptor potential vanilloid 2 in LPS-induced cytokine production in macrophages Reviewed

    Kenji Yamashiro, Tetsuo Sasano, Katsuyoshi Tojo, Iyuki Namekata, Junko Kurokawa, Naoki Sawada, Takayoshi Suganami, Yasutomi Kamei, Hikaru Tanaka, Naoko Tajima, Kazunori Utsunomiya, Yoshihiro Ogawa, Tetsushi Furukawa

    Biochemical and Biophysical Research Communications   398 ( 2 )   284 - 289   2010.7

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    DOI: 10.1016/j.bbrc.2010.06.082

  • The cathepsin L gene is a direct target of FOXO1 in skeletal muscle Reviewed

    Yoshihiro Yamazaki, Yasutomi Kamei, Satoshi Sugita, Fumiko Akaike, Sayaka Kanai, Shinji Miura, Yukio Hirata, Bruce R. Troen, Tadahiro Kitamura, Ichizo Nishino, Takayoshi Suganami, Osamu Ezaki, Yoshihiro Ogawa

    Biochemical Journal   427 ( 1 )   171 - 178   2010.4

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    DOI: 10.1042/BJ20091346

  • Increased expression of DNA methyltransferase 3a in obese adipose tissue Studies with transgenic mice Reviewed

    Yasutomi Kamei, Takayoshi Suganami, Tatsuya Ehara, Sayaka Kanai, Koji Hayashi, Yuji Yamamoto, Shinji Miura, Osamu Ezaki, Masaki Okano, Yoshihiro Ogawa

    Obesity   18 ( 2 )   314 - 321   2010.2

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    DOI: 10.1038/oby.2009.246

  • Role of central leptin signaling in renal macrophage infiltration Reviewed

    Miyako Tanaka, Takayoshi Suganami, Satoshi Sugita, Yuri Shimoda, Masato Kasahara, Seiichiro Aoe, Motohiro Takeya, Shu Takeda, Yasutomi Kamei, Yoshihiro Ogawa

    Endocrine Journal   57 ( 1 )   61 - 72   2010.2

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    DOI: 10.1507/endocrj.K09E-296

  • Integrated network systems and evolutionary developmental endocrinology Reviewed

    Hiroyuki Koshiyama, Yoshihiro Ogawa, Kiyoshi Tanaka, Issei Tanaka

    Medical Hypotheses   74 ( 1 )   132 - 138   2010.1

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    DOI: 10.1016/j.mehy.2009.07.028

  • Isocaloric high-protein diet as well as branched-chain amino acids supplemented diet partially alleviates adverse consequences of maternal undernutrition on fetal growth Reviewed

    Haruta Mogami, Shigeo Yura, Hiroaki Itoh, Makoto Kawamura, Tsuyoshi Fujii, Ayako Suzuki, Seiichiro Aoe, Yoshihiro Ogawa, Norimasa Sagawa, Ikuo Konishi, Shingo Fujii

    Growth Hormone and IGF Research   19 ( 6 )   478 - 485   2009.12

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    DOI: 10.1016/j.ghir.2009.03.002

  • Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated fatty Acid/Toll-like receptor 4 signaling and macrophage activation in obese adipose tissue Reviewed

    Takayoshi Suganami, Xunmei Yuan, Yuri Shimoda, Kozue Uchio-Yamada, Nobutaka Nakagawa, Ibuki Shirakawa, Takako Usami, Takamitsu Tsukahara, Keizo Nakayama, Yoshihiro Miyamoto, Kazuki Yasuda, Junichiro Matsuda, Yasutomi Kamei, Shigetaka Kitajima, Yoshihiro Ogawa

    Circulation research   105 ( 1 )   25 - 32   2009.7

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    DOI: 10.1161/CIRCRESAHA.109.196261

  • Overexpression of FOXO1 in skeletal muscle does not alter longevity in mice Reviewed

    Tsuyoshi Chiba, Yasutomi Kamei, Takahiko Shimizu, Takuji Shirasawa, Aki Katsumata, Lisa Shiraishi, Satoshi Sugita, Yoshihiro Ogawa, Shinji Miura, Osamu Ezaki

    Mechanisms of Ageing and Development   130 ( 7 )   420 - 428   2009.7

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    DOI: 10.1016/j.mad.2009.04.004

  • Inflammatory changes in obese adipose tissue Reviewed

    Ayaka Ito, Takayoshi Suganami, Yoshihiro Ogawa

    Nippon rinsho. Japanese journal of clinical medicine   67 ( 2 )   270 - 276   2009.1

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  • Highly purified eicosapentaenoic acid reduces cardio-ankle vascular index in association with decreased serum amyloid A-LDL in metabolic syndrome Reviewed

    Noriko Satoh, Akira Shimatsu, Kazuhiko Kotani, Akihiro Himeno, Takafumi Majima, Kazunori Yamada, Takayoshi Suganami, Yoshihiro Ogawa

    Hypertension Research   32 ( 11 )   1004 - 1008   2009

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    DOI: 10.1038/hr.2009.145

  • Isocaloric high-protein diet ameliorates systolic blood pressure increase and cardiac remodeling caused by maternal caloric restriction in adult mouse offspring Reviewed

    Makoto Kawamura, Hiroaki Itoh, Shigeo Yura, Haruta Mogami, Tsuyoshi Fujii, Hisashi Makino, Yoshihiro Miyamoto, Yasunao Yoshimasa, Seiichiro Aoe, Yoshihiro Ogawa, Norimasa Sagawa, Norio Kanayama, Ikuo Konishi

    Endocrine Journal   56 ( 5 )   679 - 689   2009

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    DOI: 10.1507/endocrj.K08E-286

  • Evaluation of the cardio-ankle vascular index, a new indicator of arterial stiffness independent of blood pressure, in obesity and metabolic syndrome Reviewed

    Noriko Satoh, Akira Shimatsu, Yasuhisa Kato, Rika Araki, Kazunori Koyama, Taiichiro Okajima, Makito Tanabe, Mariko Ooishi, Kazuhiko Kotani, Yoshihiro Ogawa

    Hypertension Research   31 ( 10 )   1921 - 1930   2008.12

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    DOI: 10.1291/hypres.31.1921

  • Skeltal muscle function and FOXO Reviewed

    Yasutomi Kamei, Yoshihiro Ogawa

    Seikagaku   80 ( 11 )   1026 - 1029   2008.12

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  • Role of CC chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue Reviewed

    Ayaka Ito, Takayoshi Suganami, Akira Yamauchi, Mikako Degawa-Yamauchi, Miyako Tanaka, Ryuji Kouyama, Yuko Kobayashi, Nao Nitta, Kazuki Yasuda, Yukio Hirata, William A. Kuziel, Motohiro Takeya, Shiro Kanegasaki, Yasutomi Kamei, Yoshihiro Ogawa

    Journal of Biological Chemistry   283 ( 51 )   35715 - 35723   2008.12

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    DOI: 10.1074/jbc.M804220200

  • In vivo and in vitro inhibition of monocyte adhesion to endothelial cells and endothelial adhesion molecules by eicosapentaenoic acid Reviewed

    Hideto Yamada, Masayuki Yoshida, Yasutaka Nakano, Takayoshi Suganami, Noriko Satoh, Tomoya Mita, Kosuke Azuma, Michiko Itoh, Yukio Yamamoto, Yasutomi Kamei, Minoru Horie, Hirotaka Watada, Yoshihiro Ogawa

    Arteriosclerosis, thrombosis, and vascular biology   28 ( 12 )   2173 - 2179   2008.12

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    DOI: 10.1161/ATVBAHA.108.171736

  • Adrenomedullin inhibits connective tissue growth factor expression, extracellular signal-regulated kinase activation and renal fibrosis Reviewed

    T. Nagae, K. Mori, M. Mukoyama, M. Kasahara, H. Yokoi, T. Suganami, K. Sawai, T. Yoshioka, M. Koshikawa, Y. Saito, Y. Ogawa, T. Kuwabara, I. Tanaka, A. Sugawara, T. Kuwahara, K. Nakao

    Kidney International   74 ( 1 )   70 - 80   2008.7

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    DOI: 10.1038/ki.2008.98

  • Effect of peroxisome proliferator-activated receptor-α ligands in the interaction between adipocytes and macrophages in obese adipose tissue Reviewed

    16 ( 6 )   1199 - 1207   2008.6

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    Objective: This study was designed to examine the effect of peroxisome proliferator-activated receptor-α (PPAR-α) ligands on the inflammatory changes induced by the interaction between adipocytes and macrophages in obese adipose tissue. Methods and Procedures: PPAR-α ligands (Wy-14,643 and fenofibrate) were added to 3T3-L1 adipocytes, RAW264 macrophages, or co-culture of 3T3-L1 adipocytes and RAW264 macrophages in vitro, and monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-α (TNF-α) mRNA expression and secretion were examined. PPAR-α ligands were administered to genetically obese ob/ob mice for 2 weeks. Moreover, the effect of PPAR-α ligands was also evaluated in the adipose tissue explants and peritoneal macrophages obtained from PPAR-α-deficient mice. Results: In the co-culture of 3T3-L1 adipocytes and RAW264 macrophages, PPAR-α ligands reduced MCP-1 and TNF-α mRNA expression and secretion in vitro relative to vehicle-treated group. The anti-inflammatory effect of Wy-14,643 was observed in adipocytes treated with macrophage-conditioned media or mouse recombinant TNF-α and in macrophages treated with adipocyte-conditioned media or palmitate. Systemic administration of PPAR-α ligands inhibited the inflammatory changes in adipose tissue from ob/ob mice. Wy-14,643 also exerted an anti-inflammatory effect in the adipose tissue explants but not in peritoneal macrophages obtained from PPAR-α-deficient mice. Discussion: This study provides evidence for the anti-inflammatory effect of PPAR-α ligands in the interaction between adipocytes and macrophages in obese adipose tissue, thereby improving the dysregulation of adipocytokine production and obesity-related metabolic syndrome.

    DOI: 10.1038/oby.2008.62

  • Neonatal exposure to leptin augments diet-induced obesity in leptin-deficient ob/ob mice Reviewed

    Shigeo Yura, Hiroaki Itoh, Norimasa Sagawa, Hiroshi Yamamoto, Hiroaki Masuzaki, Kazuwa Nakao, Makoto Kawamura, Haruta Mogami, Yoshihiro Ogawa, Shingo Fujii

    Obesity   16 ( 6 )   1289 - 1295   2008.6

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    DOI: 10.1038/oby.2008.57

  • Regulation of SREBP1c gene expression in skeletal muscle Role of retinoid x receptor/liver x receptor and forkhead-O1 transcription factor Reviewed

    Yasutomi Kamei, Shinji Miura, Takayoshi Suganami, Fumiko Akaike, Sayaka Kanai, Satoshi Sugita, Aki Katsumata, Hiroyuki Aburatani, Terry G. Unterman, Osamu Ezaki, Yoshihiro Ogawa

    Endocrinology   149 ( 5 )   2293 - 2305   2008.5

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    DOI: 10.1210/en.2007-1461

  • Overexpression of connective tissue growth factor in podocytes worsens diabetic nephropathy in mice Reviewed

    H. Yokoi, M. Mukoyama, K. Mori, M. Kasahara, T. Suganami, K. Sawai, T. Yoshioka, Y. Saito, Y. Ogawa, T. Kuwabara, A. Sugawara, K. Nakao

    Kidney International   73 ( 4 )   446 - 455   2008.1

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    DOI: 10.1038/sj.ki.5002722

  • Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor Reviewed

    Atsutaka Yasui, Hitoshi Nishizawa, Yosuke Okuno, Kentaro Morita, Hironori Kobayashi, Kenichiro Kawai, Morihiro Matsuda, Ken Kishida, Shinji Kihara, Yasutomi Kamei, Yoshihiro Ogawa, Tohru Funahashi, Iichiro Shimomura

    Biochemical and Biophysical Research Communications   364 ( 2 )   358 - 365   2007.12

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    DOI: 10.1016/j.bbrc.2007.10.013

  • Intact kinase homology domain of natriuretic peptide receptor-B is essential for skeletal development Reviewed

    Rumi Hachiya, Yuko Ohashi, Yasutomi Kamei, Takayoshi Suganami, Hiroshi Mochizuki, Norimasa Mitsui, Masaaki Saitoh, Masako Sakuragi, Gen Nishimura, Hirofumi Ohashi, Tomonobu Hasegawa, Yoshihiro Ogawa

    Journal of Clinical Endocrinology and Metabolism   92 ( 10 )   4009 - 4014   2007.10

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    DOI: 10.1210/jc.2007-1101

  • Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects Reviewed

    Michiko Itoh, Takayoshi Suganami, Noriko Satoh, Kanami Tanimoto-Koyama, Xunmei Yuan, Miyako Tanaka, Hiroyuki Kawano, Takashi Yano, Seiichiro Aoe, Motohiro Takeya, Akira Shimatsu, Hideshi Kuzuya, Yasutomi Kamei, Yoshihiro Ogawa

    Arteriosclerosis, thrombosis, and vascular biology   27 ( 9 )   1918 - 1925   2007.9

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    DOI: 10.1161/ATVBAHA.106.136853

  • Macrophage-colony stimulating factor in obese adipose tissue Studies with heterozygous op/+ mice Reviewed

    Satoshi Sugita, Yasutomi Kamei, Jun Ichiro Oka, Takayoshi Suganami, Yoshihiro Ogawa

    Obesity   15 ( 8 )   1988 - 1995   2007.8

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    DOI: 10.1038/oby.2007.237

  • Role of MAPK phosphatase-1 in the induction of monocyte chemoattractant protein-1 during the course of adipocyte hypertrophy Reviewed

    Ayaka Ito, Takayoshi Suganami, Yoshihiro Miyamoto, Yasunao Yoshimasa, Motohiro Takeya, Yasutomi Kamei, Yoshihiro Ogawa

    Journal of Biological Chemistry   282 ( 35 )   25445 - 25452   2007.8

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    DOI: 10.1074/jbc.M701549200

  • A novel heterozygous splice-site mutation of LEM domain-containing 3 in a Japanese kindred with Buschke-Ollendorff syndrome Reviewed

    H. Kobayashi, M. Kasahara, M. Hino, S. Takahara, K. Ikeda, C. Son, T. Iwakura, N. Matsuoka, A. Yoshimoto, N. Ohgo, R. Kasai, T. Ishihara, Y. Ogawa

    Journal of Endocrinological Investigation   30 ( 3 )   263 - 265   2007.3

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    DOI: 10.1007/BF03347437

  • Effect of acute activation of 5′-AMP-activated protein kinase on glycogen regulation in isolated rat skeletal muscle Reviewed

    102 ( 3 )   1007 - 1013   2007.3

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    5′-AMP-activated protein kinase (AMPK) has been implicated in glycogen metabolism in skeletal muscle. However, the physiological relevance of increased AMPK activity during exercise has not been fully clarified. This study was performed to determine the direct effects of acute AMPK activation on muscle glycogen regulation. For this purpose, we used an isolated rat muscle preparation and pharmacologically activated AMPK with 5-aminoimidazole-4- carboxamide-1-β-D-ribonucleoside (AICAR). Tetanic contraction in vitro markedly activated the α1- and α2-isoforms of AMPK, with a corresponding increase in the rate of 3-O-methylglucose uptake. Incubation with AICAR elicited similar enhancement of AMPK activity and 3-O-methylglucose uptake in rat epitrochlearis muscle. In contrast, whereas contraction stimulated glycogen synthase (GS), AICAR treatment decreased GS activity. Insulin-stimulated GS activity also decreased after AICAR treatment. Whereas contraction activated glycogen phosphorylase (GP), AICAR did not alter GP activity. The muscle glycogen content decreased in response to contraction but was unchanged by AICAR. Lactate release was markedly increased when muscles were stimulated with AICAR in buffer containing glucose, indicating that the glucose taken up into the muscle was catabolized via glycolysis. Our results suggest that AMPK does not mediate contraction-stimulated glycogen synthesis or glycogenolysis in skeletal muscle and also that acute AMPK activation leads to an increased glycolytic flux by antagonizing contraction-stimulated glycogen synthesis.

    DOI: 10.1152/japplphysiol.01034.2006

  • Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation Reviewed

    Takayoshi Suganami, Tae Mieda, Michiko Itoh, Yuri Shimoda, Yasutomi Kamei, Yoshihiro Ogawa

    Biochemical and Biophysical Research Communications   354 ( 1 )   45 - 49   2007.3

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    DOI: 10.1016/j.bbrc.2006.12.190

  • Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy Reviewed

    Ken Ebihara, Toru Kusakabe, Masakazu Hirata, Hiroaki Masuzaki, Fumiko Miyanaga, Nozomi Kobayashi, Tomohiro Tanaka, Hideki Chusho, Takashi Miyazawa, Tatsuya Hayashi, Kiminori Hosoda, Yoshihiro Ogawa, Alex M. DePaoli, Masanori Fukushima, Kazuwa Nakao

    Journal of Clinical Endocrinology and Metabolism   92 ( 2 )   532 - 541   2007.2

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    DOI: 10.1210/jc.2006-1546

  • Peg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner Reviewed

    Yasutomi Kamei, Takayoshi Suganami, Takashi Kohda, Fumitoshi Ishino, Kazuki Yasuda, Shinji Miura, Osamu Ezaki, Yoshihiro Ogawa

    FEBS Letters   581 ( 1 )   91 - 96   2007.1

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    DOI: 10.1016/j.febslet.2006.12.002

  • A novel heterozygous deletion frameshift mutation of GATA3 in a Japanese kindred with the hypoparathyroidism, deafness and renal dysplasia syndrome [2] Reviewed

    H. Kobayashi, M. Kasahara, M. Hino, H. Yoshimura, S. Takahara, K. Ikeda, C. Son, T. Iwakura, A. Yoshimoto, T. Ishihara, Y. Ogawa

    Journal of Endocrinological Investigation   29 ( 9 )   851 - 853   2006.10

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    DOI: 10.1007/BF03347383

  • Prohormone convertase 1 (PC1) gene mutation Reviewed

    Noriko Sato, Yoshihiro Ogawa

    Nippon rinsho. Japanese journal of clinical medicine   Suppl 3   249 - 253   2006.9

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  • An α-glucosidase inhibitor, voglibose, reduces oxidative stress markers and soluble intercellular adhesion molecule 1 in obese type 2 diabetic patients Reviewed

    55 ( 6 )   786 - 793   2006.6

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    Postprandial hyperglycemia and hyperlipidemia are considered risk factors for cardiovascular disease. This study was designed to elucidate whether improving the postprandial state by voglibose, an α-glucosidase inhibitor, leads to the reduction of oxidative stress markers and soluble adhesion molecules in obese type 2 diabetic patients. A total of 30 Japanese obese type 2 diabetic patients were randomly assigned and treated for 3 weeks with either diet alone (the control group) or diet plus voglibose (0.9 mg daily) (the voglibose group) (n = 15 each). Analysis of the diurnal metabolic profiles revealed a significant reduction of postprandial hyperglycemia and hyperlipidemia in the voglibose group relative to the control group (P < .05), despite the similar improvement in body mass index and hemoglobin A1c in both groups. Voglibose also decreased significantly the plasma levels of soluble intercellular adhesion molecule 1 and urinary excretion of 8-iso-prostaglandin F2α and 8-hydroxydeoxyguanosine (P < .01) and C-reactive protein (P < .05) relative to the control group. In conclusion, this study represents the first demonstration that voglibose reduces oxidative stress generation and soluble intercellular adhesion molecule 1 in parallel with the reduction of postprandial hyperglycemia and hyperlipidemia in obese type 2 diabetic patients.

    DOI: 10.1016/j.metabol.2006.01.016

  • A novel heterozygous missense mutation in the vasopressin moiety is identified in a Japanese person with neurohypophyseal diabetes insipidus Reviewed

    Hiromasa Kobayashi, I. Fujisawa, K. Ikeda, C. Son, T. Iwakura, A. Yoshimoto, M. Kasahara, T. Ishihara, Y. Ogawa

    Journal of Endocrinological Investigation   29 ( 3 )   252 - 256   2006.3

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    DOI: 10.1007/BF03345549

  • α2 Isoform-specific activation of 5′ adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1- β-D-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle Reviewed

    55 ( 3 )   300 - 308   2006.3

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    5′Adenosine monophosphate-activated protein kinase (AMPK) has been implicated in exercise-induced stimulation of glucose metabolism in skeletal muscle. Although skeletal muscle expresses both the α1 and α2 isoforms of AMPK, the α2 isoform is activated predominantly in response to moderate-intensity endurance exercise in human and animal muscles. The purpose of this study was to determine whether activation of α2 AMPK plays a role in increasing the rate of glucose transport, promoting glucose transporter 4 (GLUT4) expression, and enhancing insulin sensitivity in skeletal muscle. To selectively activate the α2 isoform, we used 5-aminoimidazole-4- carboxamide-1-β-d-ribonucleoside (AICAR), which is metabolized in muscle cells and preferentially stimulates the α2 isoform. Subcutaneous administration of 250 mg/kg AICAR activated the α2 isoform for 90 minutes, but not the α1 isoform in hind limb muscles of the C57/B6J mouse. The maximal activation of the α2 isoform was observed 30 to 60 minutes after administration of AICAR and was similar to the activation induced by a 30-minute swim in a current pool. The increase in α2 activity paralleled the phosphorylation of Thr172, the essential residue for full kinase activation, and the activity of acetyl-coenzyme A carboxylase β, a known substrate of AMPK in skeletal muscle. Subcutaneous injection of AICAR rapidly increased, by 30%, the rate of 2-deoxyglucose (2DG) transport into soleus muscle; 2DG transport increased within 30 minutes and remained elevated for 4 hours after administration of AICAR. Repeated intraperitoneal injection of AICAR, 3 times a day for 4 to 7 days, increased soleus GLUT4 protein by 30% concomitant with a significant 20% increase in insulin-stimulated 2DG transport. These data suggest that moderate endurance exercise promotes glucose transport, GLUT4 expression, and insulin sensitivity in skeletal muscle at least partially via activation of the α2 isoform of AMPK.

    DOI: 10.1016/j.metabol.2005.09.003

  • Clinical features of the metabolic syndrome and its molecular mechanism Reviewed

    Noriko Sato, Yoshihiro Ogawa

    Nippon rinsho. Japanese journal of clinical medicine   64 Suppl 9   349 - 355   2006.1

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  • Pathophysiologic role of macrophages infiltrated into obese adipose tissue Reviewed

    Takayoshi Suganami, Yoshihiro Ogawa

    Nippon rinsho. Japanese journal of clinical medicine   64 Suppl 9   198 - 202   2006.1

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  • POMC gene mutations in human Reviewed

    Kazumichi Onigata, Yoshihiro Ogawa

    Nippon rinsho. Japanese journal of clinical medicine   Suppl 3   255 - 259   2006.1

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  • Leptin Reviewed

    Noriko Satoh, Yoshihiro Ogawa

    Nippon rinsho. Japanese journal of clinical medicine   64 Suppl 5   168 - 172   2006.1

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  • The unified hypothesis of interactions among the bone, adipose and vascular systems 'Osteo-lipo-vascular interactions' Reviewed

    Hiroyuki Koshiyama, Yoshihiro Ogawa, Kiyoshi Tanaka, Issei Tanaka

    Medical Hypotheses   66 ( 5 )   960 - 963   2006

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    DOI: 10.1016/j.mehy.2005.11.024

  • Transgenic expression of mutant peroxisome proliferator-activated receptor γ in liver precipitates fasting-induced steatosis but protects against high-fat diet-induced steatosis in mice Reviewed

    54 ( 11 )   1490 - 1498   2005.11

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    Steatosis is one of the most common liver diseases and is associated with the metabolic syndrome. A line of evidence suggests that peroxisome proliferator-activated receptor (PPAR) α and PPARγ are involved in its pathogenesis. Hepatic overexpression of PPARγ1 in mice provokes steatosis, whereas liver-specific PPARγ disruption ameliorates steatosis in ob/ob mice, suggesting that hepatic PPARγ functions as an aggravator of steatosis. In contrast, PPARα-null mice are susceptible to steatosis because of reduced hepatic fatty acid oxidation. PPARγ with mutations in its C-terminal ligand-binding domain (L468A/E471A mutant PPARγ1) have been reported as a constitutive repressor of both PPARα and PPARγ activities in vitro. To elucidate the effect of cosuppression of PPARα and PPARγ on steatosis, we generated mutant PPARγ transgenic mice (Liver mt PPARγ Tg) under the control of liver-specific human serum amyloid P component promoter. In the liver of transgenic mice, PPARα and PPARγ agonist-induced augmentation of the expression of downstream target genes of PPARα and PPARγ, respectively, was significantly attenuated, suggesting PPARα and PPARγ cosuppression in vivo. Suppression of PPARα and PPARγ target genes was also observed in the fasted and high-fat-fed conditions. Liver mt PPARγ Tg were susceptible to fasting-induced steatosis while being protected against high-fat diet-induced steatosis. The opposite hepatic outcomes in Liver mt PPARγ Tg as a result of fasting and high-fat feeding may indicate distinct roles of PPARα and PPARγ in 2 different types of nutritionally provoked steatosis.

    DOI: 10.1016/j.metabol.2005.05.015

  • Attenuation of diet-induced weight gain and adiposity through increased energy expenditure in mice lacking angiotensin II type 1a receptor Reviewed

    Ryuji Kouyama, Takayoshi Suganami, Junko Nishida, Miyako Tanaka, Takuya Toyoda, Minako Kiso, Tsuyoshi Chiwata, Yoshihiro Miyamoto, Yasunao Yoshimasa, Akiyoshi Fukamizu, Masatsugu Horiuchi, Yukio Hirata, Yoshihiro Ogawa

    Endocrinology   146 ( 8 )   3481 - 3489   2005.8

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    DOI: 10.1210/en.2005-0003

  • Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice Reviewed

    Hiroshi Iwakura, Kiminori Hosoda, Choel Son, Junji Fujikura, Tsutomu Tomita, Michio Noguchi, Hiroyuki Ariyasu, Kazuhiko Takaya, Hiroaki Masuzaki, Yoshihiro Ogawa, Tatsuya Hayashi, Gen Inoue, Takashi Akamizu, Hiroshi Hosoda, Masayasu Kojima, Hiroshi Itoh, Shinya Toyokuni, Kenji Kangawa, Kazuwa Nakao

    Journal of Biological Chemistry   280 ( 15 )   15247 - 15256   2005.4

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    DOI: 10.1074/jbc.M411358200

  • GC79/TRPS1 and tumorigenesis in humans [3] Reviewed

    Hiromasa Kobayashi, Kaori Ikeda, Cheol Son, Toshio Iwakura, Takashi Ishihara, Megumu Hino, Tatsuhide Inoue, Eiji Nii, Yoshihiro Ogawa

    American Journal of Medical Genetics   134 A ( 3 )   341 - 343   2005.4

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    DOI: 10.1002/ajmg.a.30596

  • New prospects for the treatment of obesity - Leptin and the discovery of anti-obesity drugs - Reviewed

    Yoshihiro Ogawa

    Japan Medical Association Journal   48 ( 2 )   64 - 67   2005.2

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  • Prevention and reversal of renal injury by leptin in a new mouse model of diabetic nephropathy Reviewed

    Takayoshi Suganami, Masashi Mukoyama, Kiyoshi Mori, Hideki Yokoi, Masao Koshikawa, Kazutomo Sawai, Shuji Hidaka, Ken Ebihara, Tomohiro Tanaka, Akira Sugawara, Hiroshi Kawachi, Charles Viason, Yoshihiro Ogawa, Kazuwa Nakao

    FASEB Journal   19 ( 1 )   127 - 129   2005.1

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    DOI: 10.1096/fj.04-2183fje

  • Association of Ob-R Gene Polymorphism and Insulin Resistance in Japanese Men Reviewed

    Akiko Takahashi-Yasuno, Hiroaki Masuzaki, Takashi Miyawaki, Naoki Matsuoka, Yoshihiro Ogawa, Tatsuya Hayashi, Kiminori Hosoda, Yasunao Yoshimasa, Gen Inoue, Kazuwa Nakao

    Metabolism: Clinical and Experimental   53 ( 5 )   650 - 654   2004.5

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    DOI: 10.1016/j.metabol.2003.12.012

  • Gene and Phenotype Analysis of Congenital Generalized Lipodystrophy in Japanese A Novel Homozygous Nonsense Mutation in Seipin Gene Reviewed

    Ken Ebihara, Toru Kusakabe, Hiroaki Masuzaki, Nozomi Kobayashi, Tomohiro Tanaka, Hideki Chusho, Fumiko Miyanaga, Takashi Miyazawa, Tatsuya Hayashi, Kiminori Hosoda, Yoshihiro Ogawa, Kazuwa Nakao

    Journal of Clinical Endocrinology and Metabolism   89 ( 5 )   2360 - 2364   2004.5

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    DOI: 10.1210/jc.2003-031211

  • Significant increase in maternal plasma leptin concentration in induced delivery A possible contribution of pro-inflammatory cytokines to placental leptin secretion Reviewed

    Mercy A. Nuamah, Shigeo Yura, Norimasa Sagawa, Hiroaki Itoh, Hiroko Mise, Daizo Korita, Kazuyo Kakui, Maki Takemura, Yoshihiro Ogawa, Kazuwa Nakao, Shingo Fujii

    Endocrine Journal   51 ( 2 )   177 - 187   2004.4

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    DOI: 10.1507/endocrj.51.177

  • Biological function of leptin and obesity-related diseases Reviewed

    Yoshihiro Ogawa

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   93 ( 11 )   2435 - 2441   2004.1

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    DOI: 10.2169/naika.93.2435

  • Involvement of leptin in the pathogenesis of hypertension and hypertensive target-organ damage Reviewed

    Yoshihiro Ogawa, Kazuwa Nakao

    Nippon rinsho. Japanese journal of clinical medicine   62 Suppl 3   216 - 221   2004.1

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  • Growth promoting effect of natriuretic peptides on bones formed through endochondral ossification Reviewed

    Akihiro Yasoda, Yasato Komatsu, Kazuwa Nakao, Yoshihiro Ogawa

    Nippon rinsho. Japanese journal of clinical medicine   62 Suppl 9   60 - 64   2004.1

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  • C-type natriuretic peptide(CNP)--a novel stimulator of bone growth formed through endochondral ossification Reviewed

    Akihiro Yasoda, Yasato Komatsu, Kazuwa Nakao, Yoshihiro Ogawa

    Nippon rinsho. Japanese journal of clinical medicine   62 Suppl 2   77 - 81   2004.1

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  • Leptin receptor polymorphism is associated with serum lipid levels and impairment of cholesterol lowering effect by simvastatin in Japanese men Reviewed

    Akiko Takahashi-Yasuno, Hiroaki Masuzaki, Takashi Miyawaki, Yoshihiro Ogawa, Naoki Matsuoka, Tatsuya Hayashi, Kiminori Hosoda, Gen Inoue, Yasunao Yoshimasa, Kazuwa Nakao

    Diabetes Research and Clinical Practice   62 ( 3 )   169 - 175   2003.12

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    DOI: 10.1016/S0168-8227(03)00163-3

  • Angiotensin II-induced ventricular hypertrophy and extracellular signal-regulated kinase activation are suppressed in mice overexpressing brain natriuretic peptide in circulation Reviewed

    Nobuki Takahashi, Yoshihiko Saito, Koichiro Kuwahara, Masaki Harada, Ichiro Kishimoto, Yoshihiro Ogawa, Rika Kawakami, Yasuaki Nakagawa, Micio Nakanishi, Kazuwa Nakao

    Hypertension Research   26 ( 10 )   847 - 853   2003.10

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    DOI: 10.1291/hypres.26.847

  • Leptin as an adjunct of insulin therapy in insulin-deficient diabetes Reviewed

    F. Miyanaga, Y. Ogawa, K. Ebihara, S. Hidaka, T. Tanaka, S. Hayashi, H. Masuzaki, K. Nakao

    Diabetologia   46 ( 10 )   1329 - 1337   2003.10

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    DOI: 10.1007/s00125-003-1193-6

  • Leptin Reviewed

    Yoshihiro Ogawa, K. Nakao

    Journal of the Japan Diabetes Society   46 ( 9 )   730 - 732   2003.10

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  • Free-to-total leptin ratio in maternal plasma is constant throughout human pregnancy Reviewed

    Mercy A. Nuamah, Norimasa Sagawa, Shigeo Yura, Hiroko Mise, Hiroaki Itoh, Yoshihiro Ogawa, Kazuwa Nakao, Shingo Fujii

    Endocrine Journal   50 ( 4 )   421 - 428   2003.8

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    DOI: 10.1507/endocrj.50.421

  • Antiobesity and antidiabetic effects of brain-derived neurotrophic factor in rodent models of leptin resistance Reviewed

    T. Nakagawa, Y. Ogawa, K. Ebihara, M. Yamanaka, A. Tsuchida, M. Taiji, H. Noguchi, K. Nakao

    International Journal of Obesity   27 ( 5 )   557 - 565   2003.5

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    DOI: 10.1038/sj.ijo.0802265

  • Effects of obstructive sleep apnea syndrome on serum aminotransferase levels in obese patients Reviewed

    Kazuo Chin, Takaya Nakamura, Kenichi Takahashi, Kensuke Sumi, Yoshihiro Ogawa, Hiroaki Masuzaki, Shigeo Muro, Noboru Hattori, Hisako Matsumoto, Akio Niimi, Tsutomu Chiba, Kazuwa Nakao, Michiaki Mishima, Motoharu Ohi, Takashi Nakamura

    American Journal of Medicine   114 ( 5 )   370 - 376   2003.4

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    DOI: 10.1016/S0002-9343(02)01570-X

  • Facilitation by endogenous prostaglandins of capsaicin-induced gastric protection in rodents through EP2 and IP receptors Reviewed

    Koji Takeuchi, Shinichi Kato, Masanori Takeeda, Yoshihiro Ogawa, Masato Nakashima, Masahiro Matsumoto

    Journal of Pharmacology and Experimental Therapeutics   304 ( 3 )   1055 - 1062   2003.3

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    DOI: 10.1124/jpet.102.044156

  • Significance and therapeutic potential of the natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway in vascular regeneration Reviewed

    Kenichi Yamahara, Hiroshi Itoh, Tae Hwa Chun, Yoshihiro Ogawa, Jun Yamashita, Naoki Sawada, Yasutomo Fukunaga, Masakatsu Sone, Takami Yurugi-Kobayashi, Kazutoshi Miyashita, Hirokazu Tsujimoto, Hyun Kook, Robert Feil, David L. Garbers, Franz Hofmann, Kazuwa Nakao

    Proceedings of the National Academy of Sciences of the United States of America   100 ( 6 )   3404 - 3409   2003.3

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    DOI: 10.1073/pnas.0538059100

  • Congenital obesity caused by a novel mutation of human melanocortin receptor 4 (MC 4 R) Reviewed

    Y. Ogawa, H. Kobayashi, K. Ebihara, T. Hayashi, K. Hosoda, H. Inoue, T. Ishihara, H. Kurahachi, K. Nakao

    Journal of the Japan Diabetes Society   46 ( 1 )   29 - 33   2003.1

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  • Significance of C-type natriuretic peptide (CNP) in endochondral ossification Analysis of CNP knockout mice Reviewed

    Yasato Komatsu, Hideki Chusho, Naohisa Tamura, Akihiro Yasoda, Takashi Miyazawa, Michio Suda, Masako Miura, Yoshihiro Ogawa, Kazuwa Nakao

    Journal of Bone and Mineral Metabolism   20 ( 6 )   331 - 336   2002.12

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    DOI: 10.1007/s007740200048

  • Ghrelin expression in islet cell tumors Augmented expression of ghrelin in a case of glucagonoma with multiple endocrine neoplasm type I Reviewed

    Hiroshi Iwakura, Kiminori Hosoda, Ryuichiro Doi, Izumi Komoto, Haruo Nishimura, Choel Son, Junji Fujikura, Tsutomu Tomita, Kazuhiko Takaya, Yoshihiro Ogawa, Tatsuya Hayashi, Gen Inoue, Takashi Akamizu, Hiroshi Hosoda, Masayasu Kojima, Kenji Kangawa, Masayuki Imamura, Kazuwa Nakao

    Journal of Clinical Endocrinology and Metabolism   87 ( 11 )   4885 - 4888   2002.11

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    DOI: 10.1210/jc.2002-020882

  • Ulcerogenic influence of selective cyclooxygenase-2 inhibitors in the rat stomach with adjuvant-induced arthritis Reviewed

    Shinichi Kato, Yoshihiro Ogawa, Kenji Kanatsu, Mitsuaki Okayama, Toshio Watanabe, Tetsuo Arakawa, Koji Takeuchi

    Journal of Pharmacology and Experimental Therapeutics   303 ( 2 )   503 - 509   2002.11

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    DOI: 10.1124/jpet.102.040659

  • Possible role of placental leptin in pregnancy A review Reviewed

    Norimasa Sagawa, Shigeo Yura, Hiroaki Itoh, Kazuyo Kakui, Maki Takemura, Mercy A. Nuamah, Yoshihiro Ogawa, Hiroaki Masuzaki, Kazuwa Nakao, Shingo Fujii

    Endocrine   19 ( 1 )   65 - 71   2002.10

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    DOI: 10.1385/ENDO:19:1:65

  • Cyclic GMP-dependent protein kinase II plays a critical role in C-type natriuretic peptide-mediated endochondral ossification Reviewed

    Takashi Miyazawa, Yoshihiro Ogawa, Hideki Chusho, Akihiro Yasoda, Naohisa Tamura, Yasato Komatsu, Alexander Pfeifer, Franz Hofmann, Kazuwa Nakao

    Endocrinology   143 ( 9 )   3604 - 3610   2002.9

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    DOI: 10.1210/en.2002-220307

  • Delayed short-term secretory regulation of ghrelin in obese animals Evidenced by a specific RIA for the active form of ghrelin Reviewed

    Hiroyuki Ariyasu, Kazuhiko Takaya, Hiroshi Hosoda, Hiroshi Iwakura, Ken Ebihara, Kiyoshi Mori, Yoshihiro Ogawa, Kiminori Hosoda, Takashi Akamizu, Masayasu Kojima, Kenji Kangawa, Kazuwa Nakao

    Endocrinology   143 ( 9 )   3341 - 3350   2002.9

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    DOI: 10.1210/en.2002-220225

  • Protection against dextran sulfate sodium-induced colitis by microspheres of ellagic acid in rats Reviewed

    Y. Ogawa, K. Kanatsu, T. Iino, S. Kato, Y. I. Jeong, N. Shibata, K. Takada, K. Takeuchi

    Life Sciences   71 ( 7 )   827 - 839   2002.7

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    DOI: 10.1016/S0024-3205(02)01737-X

  • Gastric ulcerogenic responses following barrier disruption in knockout mice lacking prostaglandin EP1 receptors Reviewed

    K. Takeuchi, Y. Ogawa, S. Kagawa, H. Ukawa

    Alimentary Pharmacology and Therapeutics, Supplement   16 ( 2 )   74 - 82   2002.4

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    DOI: 10.1046/j.1365-2036.16.s2.21.x

  • Role of leptin in pregnancy - A review Reviewed

    N. Sagawa, S. Yura, H. Itoh, H. Mise, K. Kakui, D. Korita, M. Takemura, M. A. Nuamah, Y. Ogawa, H. Masuzaki, K. Nakao, S. Fujii

    Placenta   23 ( SUPPL. 1 )   S80 - S86   2002.4

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    DOI: 10.1053/plac.2002.0814

  • Pathophysiogical role of leptin in lifestyle-related diseases Studies with transgenic skinny mice overexpressing leptin Reviewed

    Yoshihiro Ogawa, Hiroaki Masuzaki, Ken Ebihara, Mitsuyo Shintani, Megumi Aizawa-Abe, Fumiko Miyanaga, Kazuwa Nakao

    Journal of Diabetes and Its Complications   16 ( 1 )   119 - 122   2002.3

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    DOI: 10.1016/S1056-8727(01)00204-5

  • Clinical implications of leptin and its potential humoral regulators in long-term low-calorie diet therapy for obese humans Reviewed

    T. Miyawaki, H. Masuzaki, Y. Ogawa, K. Hosoda, H. Nishimura, N. Azuma, A. Sugawara, I. Masuda, M. Murata, T. Matsuo, T. Hayashi, G. Inoue, Y. Yoshimasa, K. Nakao

    European Journal of Clinical Nutrition   56 ( 7 )   593 - 600   2002.1

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    DOI: 10.1038/sj.ejcn.1601363

  • Transgenic approach toward leptin biology The clinical implications of leptin for the treatment of obesity-associated diabetes and obesity-related hypertension Reviewed

    Hiroaki Masuzaki, Yoshihiro Ogawa, Megumi Aizawa-Abe, Kazuwa Nakao

    Endocrine Journal   49 ( 2 )   109 - 119   2002.1

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    DOI: 10.1507/endocrj.49.109

  • Obesity induced by abnormality in leptin receptor and melanocortin-4 receptor Reviewed

    Mitsuyo Shintani, Yoshihiro Ogawa, Kazuwa Nakao

    Nippon rinsho. Japanese journal of clinical medicine   60 ( 2 )   404 - 409   2002.1

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  • Missense mutation of TRPS1 in a family of tricho-rhino-phalangeal syndrome type III Reviewed

    Hiromasa Kobayashi, Megumu Hino, Makiko Shimodahira, Toshio Iwakura, Takashi Ishihara, Katsuji Ikekubo, Yoshihiro Ogawa, Kazuwa Nakao, Hiroyuki Kurahachi

    American Journal of Medical Genetics   107 ( 1 )   26 - 29   2002.1

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    DOI: 10.1002/ajmg.10081

  • Leptin and leptin receptor Reviewed

    Yoshihiro Ogawa, Kazuwa Nakao

    Nippon rinsho. Japanese journal of clinical medicine   60 Suppl 7   571 - 576   2002.1

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  • Insulin resistant transgenic mice Reviewed

    Ken Ebihara, Yoshihiro Ogawa, Kazuwa Nakao

    Nippon rinsho. Japanese journal of clinical medicine   60 Suppl 8   79 - 84   2002.1

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  • Effect of ellagic acid on gastric damage induced in ischemic rat stomachs following ammonia or reperfusion Reviewed

    Taeko Iino, Kimihito Tashima, Masakazu Umeda, Yoshihiro Ogawa, Masanori Takeeda, Kanji Takata, Koji Takeuchi

    Life Sciences   70 ( 10 )   1139 - 1150   2002.1

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    DOI: 10.1016/S0024-3205(01)01493-X

  • C-type natriuretic peptide/guanylate cyclase B system in ATDC5 cells, a chondrogenic cell line Reviewed

    Michio Suda, Kiyoshi Tanaka, Akihiro Yasoda, Yasato Komatsu, Hideki Chusho, Masako Miura, Naohisa Tamura, Yoshihiro Ogawa, Kazuwa Nakao

    Journal of Bone and Mineral Metabolism   20 ( 3 )   136 - 141   2002

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    DOI: 10.1007/s007740200019

  • Plasma leptin levels and cardiac sympathetic function in patients with obstructive sleep apnoea-hypopnoea syndrome Reviewed

    K. Shimizu, T. Nakamura, A. Niimi, N. Hattori, M. Mishima, K. Chin, T. Nakamura, R. Nohara, R. Hosokawa, S. Sasayama, H. Masuzaki, Y. Ogawa, K. Nakao, M. Ohi

    Thorax   57 ( 5 )   429 - 434   2002

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    DOI: 10.1136/thorax.57.5.429

  • Leptin inhibits stress-induced apoptosis of T lymphocytes Reviewed

    Y. Fujita, M. Murakami, Y. Ogawa, H. Masuzaki, M. Tanaka, S. Ozaki, K. Nakao, T. Mimori

    Clinical and Experimental Immunology   128 ( 1 )   21 - 26   2002

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    DOI: 10.1046/j.1365-2249.2002.01797.x

  • Potential molecular targets for anti-obesity drugs - After the discovery of leptin Reviewed

    S. Hidaka, Y. Ogawa, K. Nakao

    Folia Pharmacologica Japonica   118 ( 5 )   309 - 314   2001.12

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    DOI: 10.1254/fpj.118.309

  • Leptin and cardiovascular lesions Reviewed

    Y. Ogawa, M. Abe, K. Nakao

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   90 ( 4 )   705 - 710   2001.4

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    DOI: 10.2169/naika.90.705

  • Human obesity and point mutations of leptin and leptin receptor Reviewed

    H. Nishimura, Y. Ogawa, K. Nakao

    Nippon rinsho. Japanese journal of clinical medicine   59 ( 3 )   571 - 577   2001.3

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  • Decreased triglyceride-rich lipoproteins in transgenic skinny mice overexpressing leptin Reviewed

    Naoki Matsuoka, Yoshihiro Ogawa, Hiroaki Masuzaki, Ken Ebihara, Megumi Aizawa-Abe, Noriko Satoh, Eiichiro Ishikawa, Yukio Fujisawa, Atsushi Kosaki, Kazunori Yamada, Hideshi Kuzuya, Kazuwa Nakao

    American Journal of Physiology - Endocrinology and Metabolism   280 ( 2 43-2 )   E334 - E339   2001.2

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    DOI: 10.1152/ajpendo.2001.280.2.e334

  • Structures and functions of leptin and leptin receptor Reviewed

    H. Nishimura, Y. Ogawa, K. Nakao

    Nippon rinsho. Japanese journal of clinical medicine   59 Suppl 2   509 - 514   2001.2

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  • A Japanese case of congenital hyperinsulinism with hyperammonemia due to a mutation in glutamate dehydrogenase (GLUD1) gene Reviewed

    Kazuki Yasuda, Naoya Koda, Hiroko Kadowaki, Yoshihiro Ogawa, Satoshi Kimura, Takashi Kadowaki, Yasuo Akanuma

    Internal Medicine   40 ( 1 )   32 - 37   2001.1

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    DOI: 10.2169/internalmedicine.40.32

  • Up-regulation of uncoupling protein 3 gene expression by fatty acids and agonists for PPARs in L6 myotubes Reviewed

    C. Son, K. Hosoda, J. Matsuda, J. Fujikura, S. Yonemitsu, H. Iwakura, H. Masuzaki, Y. Ogawa, T. Hayashi, H. Itoh, H. Nishimura, G. Inoue, Y. Yoshimasa, Y. Yamori, K. Nakao

    Endocrinology   142 ( 10 )   4189 - 4194   2001.1

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    DOI: 10.1210/endo.142.10.8446

  • Pathology and significance of leptin resistance in obesity Reviewed

    S. Hidaka, Y. Ogawa, K. Ebihara, M. Shintani, M. Abe, F. Miyanaga, K. Nakao

    Nippon rinsho. Japanese journal of clinical medicine   59 ( 3 )   472 - 480   2001.1