学術振興会特別研究員

1993.1  

第１回日本血液学会奨励賞

1992.1  

Liquid biopsy for breast cancer and other solid tumors: a review of recent advances. Reviewed International journal

Ohmura H, Hanamura F, Okumura Y, Ando Y, Masuda T, Mimori K, Akashi K, Baba E

Breast Cancer.   2024.3

Autologous HSCT with novel agent-based induction and consolidation followed by lenalidomide maintenance for untreated multiple myeloma. Reviewed International journal

Mori Y, Takizawa J, Katsuoka Y, Takezako N, Nagafuji K, Handa H, Kuroda J, Sunami K, Kamimura T, Ogawa R, Kikushige Y, Harada M, Akashi K, Miyamoto T; Japan Study Group for Cell Therapy and Transplantation.

Cancer Sci.   2024.3

End-of-treatment 18[F]-FDG PET can predict early progression in patients receiving bendamustine-rituximab for follicular lymphoma in first relapse: a prospective West Japan hematology Study Group (W-JHS) NHL01 trial. Reviewed International journal

Kato K, Izutsu K, Nishikori M, Shibayama H, Maeda Y, Yoshimura K, Tateishi U, Miyamoto T, Matsuda Y, Ishikawa J, Rai S, Takahashi T, Yamauchi T, Matsumura I, Akashi K, Kanakura Y, Suzumiya J.

Int J Hematol.   2024.3

Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drug-induced thromboembolism. Reviewed International journal

Hatakeyama K, Kikushige Y, Ishihara D, Yamamoto S, Kawano G, Tochigi T, Miyamoto T, Sakoda T, Christoforou A, Kunisaki Y, Fukata M, Kato K, Ito T, Handa H, Akashi K.

Blood Adv.   8 ( 3 )   785 - 796   2024.2

Co-expression of regulatory B-cell markers, transforming growth factor β and interleukin-10 as a prognostic factor in diffuse large B-cell lymphoma. Reviewed International journal

254   155117.   2024.2

Tumor heterogeneity and immune-evasive T follicular cell lymphoma phenotypes at single-cell resolution. Reviewed International journal

Suma S, Suehara Y, Fujisawa M, Abe Y, Hattori K, Makishima K, Sakamoto T, Sawa A, Bando H, Kaji D, Sugio T, Kato K, Akashi K, Matsue K, Carreras J, Nakamura N, Suzuki A, Suzuki Y, Ito K, Shiiba H, Chiba S, Sakata-Yanagimoto M.

Leukemia.   38 ( 2 )   340 - 350   2024.2

Both New-Onset and Pre-Existing Hypertension Indicate Favorable Clinical Outcomes in Patients Treated With Anti-Vascular Endothelial Growth Factor Therapy. Reviewed International journal

Moriyama S, Hieda M, Kisanuki M, Kawano S, Yokoyama T, Fukata M, Kusaba H, Maruyama T, Baba E, Akashi K, Fukuda H.

Circ J.   88 ( 2 )   217 - 225   2024.1

Recent advances in the treatment strategy for AAV improved outcomes with intensive GC tapering. Reviewed International journal

Ono N, Kai T, Takeyama Y, Inoue Y, Ueda N, Nagano S, Ohta S, Inoue H, Sawabe T, Chifu Y, Yoshizawa S, Oryoji K, Kimoto Y, Miyake K, Ayano M, Mitoma H, Arinobu Y, Miyamura T, Horiuchi T, Akashi K, Tada Y, Niiro H.

Int J Rheum Dis.   27 ( 1 )   e15009.   2024.1

Real-world clinical characteristics of post-essential thrombocythemia and post-polycythemia vera myelofibrosis. Reviewed International journal

Shide K, Takenaka K, Kitanaka A, Numata A, Kameda T, Yamauchi T, Inagaki A, Mizuno S, Takami A, Ito S, Hagihara M, Usuki K, Maekawa T, Sunami K, Ueda Y, Tsutsui M, Ando M, Komatsu N, Ozawa K, Kurokawa M, Arai S, Mitani K, Akashi K, Shimoda K.

Ann Hematol.   103 ( 1 )   97 - 103   2024.1

Determination of the factors associated with antigen-specific CD4+ T-cell responses to BNT162b2 in patients with rheumatoid arthritis. Reviewed International journal

Sagawa F, Yamada H, Ayano M, Kimoto Y, Mitoma H, Ono N, Arinobu Y, Kondo M, Nakashima Y, Akashi K, Horiuchi T, Niiro H.

RMD Open.   10 ( 1 )   e003693.   2024.1

Posttransplant cyclophosphamide in unrelated and related peripheral blood stem cell transplantation from HLA-matched and 1 allele mismatched donor. Reviewed International journal

Sugita J, Kuroha T, Ishikawa J, Eto T, Fukushima K, Yokota I, Akashi K, Taniguchi S, Harada M, Teshima T.

Bone Marrow Transplant.   2023.12

Distinct features of SARS-CoV-2 humoral immunity against Omicron breakthrough infection. Reviewed International journal

Goto T, Chong Y, Tani N, Susai N, Yoshinaga T, Sasaki T, Taniguchi M, Kusakabe T, Shimono N, Akashi K, Ikematsu H.

Vaccine.   41 ( 47 )   7019 - 7025   2023.11

Impact of a third dose of anti-SARS-CoV-2 vaccine in hematopoietic cell transplant recipients: A Japanese multicenter observational study. Reviewed International journal

Mori Y, Uchida N, Wake A, Miyawaki K, Eto T, Nakamura T, Iwasaki H, Ito Y, Tanimoto K, Katayama Y, Imamura Y, Takahashi T, Fujisaki T, Kamimura T, Choi I, Ishitsuka K, Yoshimoto G, Ogawa R, Sugita J, Takamatsu Y, Tanimoto K, Hidaka T, Miyamoto T, Akashi K, Nagafuji K.

Vaccine.   41 ( 47 )   6899 - 6903   2023.11

Preferential B cell differentiation by combined immune checkpoint blockade for renal cell carcinoma is associated with clinical response and autoimmune reactions. Reviewed International journal

Uehara K, Tanoue K, Yamaguchi K, Ohmura H, Ito M, Matsushita Y, Tsuchihashi K, Tamura S, Shimokawa H, Isobe T, Shibata Y, Ariyama H, Tanaka R, Kusaba H, Yamamoto H, Oda Y, Akashi K, Baba E

Cancer Immunol Immunother.   72 ( 11 )   3543 - 3558   2023.11

Peripheral helper-T-cell-derived CXCL13 is a crucial pathogenic factor in idiopathic multicentric Castleman disease Reviewed International journal

Harada T, Kikushige Y, Miyamoto T, Uno K, Niiro H, Kawakami A, Koga T, Akashi K, Yoshizaki K.

Nat Commun.   14 ( 1 )   6959   2023.10

Anti-dsDNA IgE induces IL-4 production from basophils, potentially involved in B-cell differentiation in systemic lupus erythematosus. Reviewed International journal

Fujimoto S, Arinobu Y, Miyawaki K, Ayano M, Mitoma H, Kimoto Y, Ono N, Akashi K, Horiuchi T, Niiro H.

Rheumatology (Oxford).   62 ( 10 )   3480 - 3489   2023.10

Correlation between specific antibody response to wild-type BNT162b2 booster and the risk of breakthrough infection with omicron variants: Impact of household exposure in hospital healthcare workers. Reviewed International journal

Tani N, Ikematsu H, Goto T, Kondo S, Gondo K, Fujiyoshi N, Minami J, Harada Y, Nagano S, Horiuchi T, Kuwano H, Akashi K, Shimono N, Chong Y.

Vaccine.   41 ( 45 )   6672 - 6678   2023.10

Survival outcomes including salvage therapy of adult head and neck para-meningeal rhabdomyosarcoma: a multicenter retrospective study from Japan. Reviewed International journal

Tsuchihashi K, Ito M, Arita S, Kusaba H, Kusano W, Matsumura T, Kitazono T, Ueno S, Taguchi R, Yoshihiro T, Doi Y, Arimizu K, Ohmura H, Kajitani T, Nio K, Nakano M, Oshima K, Tamura S, Shirakawa T, Shimokawa H, Uchino K, Hanamura F, Okumura Y, Komoda M, Isobe T, Ariyama H, Esaki T, Hashimoto K, Komune N, Matsuo M, Matsumoto K, Asai K, Yoshitake T, Yamamoto H, Oda Y, Akashi K, Baba E.

BMC Cancer.   23 ( 1 )   1046   2023.10

POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis. Reviewed International journal

Nakashima K, Kunisaki Y, Hosokawa K, Gotoh K, Yao H, Yuta R, Semba Y, Nogami J, Kikushige Y, Stumpf PS, MacArthur BD, Kang D, Akashi K, Ohga S, Arai F.

Commun Biol.   6 ( 1 )   996   2023.9

Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis Reviewed International journal

Yokote A, Imazu N, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Moriyama T, Miyawaki K, Akashi K, Kitazono T, Torisu T.

J Gastroenterol. 2   58 ( 9 )   868 - 882   2023.9

Safety and efficacy of switching immunosuppressive drugs for maintenance treatment in patients with systemic lupus erythematosus: A retrospective cohort study. Reviewed International journal

Ayano M, Kimoto Y, Mitoma H, Akahoshi M, Ono N, Arinobu Y, Akashi K, Horiuchi T, Niiro H.

Mod Rheumatol.   33 ( 5 )   961 - 967   2023.8

Achievement of sufficient antibody response after a fourth dose of wild-type SARS-CoV-2 mRNA vaccine in nursing home residents. Reviewed International journal

Chong Y, Goto T, Watanabe H, Tani N, Yonekawa A, Ikematsu H, Shimono N, Tanaka Y, Akashi K.

Immun Inflamm Dis.   11 ( 8 )   e962.   2023.8

GPAM mediated lysophosphatidic acid synthesis regulates mitochondrial dynamics in acute myeloid leukemia Reviewed International journal

Irifune H, Kochi Y, Miyamoto T, Sakoda T, Kato K, Kunisaki Y, Akashi K, Kikushige Y.

Cancer Sci.   114 ( 8 )   3247 - 3258   2023.8

Integrated genetic and clinical prognostic factors for aggressive adult T-cell Reviewed International journal

Kameda T, Kataoka K, Kamiunten A, Hidaka M, Miyoshi H, Nakano N, Nosaka K, Yoshimitsu M, Yasunaga JI, Kogure Y, Shide K, Miyahara M, Sakamoto T, Akizuki K, Hidaka T, Kubuki Y, Koya J, Kawano N, Yamashita K, Kawano H, Toyama T, Maeda K, Marutsuka K, Imaizumi Y, Kato K, Sugio T, Tokunaga M, Tashiro Y, Takaori-Kondo A, Miyazaki Y, Akashi K, Ishitsuka K, Matsuoka M, Ohshima K, Watanabe T, Kitanaka A, Utsunomiya A, Ogawa S, Shimoda K.

leukemia/lymphoma   108 ( 8 )   2178 - 2191   2023.8

Human acute leukemia uses branched-chain amino acid catabolism to maintain stemness through regulating PRC2 function Reviewed International journal

Kikushige Y, Miyamoto T, Kochi Y, Semba Y, Ohishi M, Irifune H, Hatakeyama K, Kunisaki Y, Sugio T, Sakoda T, Miyawaki K, Kato K, Soga T, Akashi K.

Blood Adv.   7 ( 14 )   3592 - 3603   2023.7

IKZF1plus alterations are not associated with outcomes in Philadelphia-positive acute lymphoblastic leukemia patients enrolled in the FBMTG ALL/MRD2008 trial. Reviewed International journal

Ito Y, Ozawa H, Eto T, Miyamoto T, Kamimura T, Ogawa R, Uchida N, Wake A, Fujisaki T, Ohno Y, Takase K, Okumura H, Takamatsu Y, Kawano N, Akashi K, Nagafuji K.

Eur J Haematol.   111 ( 1 )   103 - 112   2023.7

Nationwide prospective survey of secondary myelofibrosis in Japan: superiority of DIPSS-plus to MYSEC-PM as a survival risk model. Reviewed International journal

Shide K, Takenaka K, Kitanaka A, Numata A, Kameda T, Yamauchi T, Inagaki A, Mizuno S, Takami A, Ito S, Hagihara M, Usuki K, Maekawa T, Sunami K, Ueda Y, Tsutsui M, Ando M, Komatsu N, Ozawa K, Kurokawa M, Arai S, Mitani K, Akashi K, Shimoda K.

Blood Cancer J.   13 ( 1 )   110   2023.7

Immunosuppressive therapy and humoral response to third mRNA COVID-19 vaccination with a six-month interval in rheumatic disease patients. Reviewed International journal

Kashiwado Y, Kimoto Y, Ohshima S, Sawabe T, Irino K, Nakano S, Hiura J, Yonekawa A, Wang Q, Doi G, Ayano M, Mitoma H, Ono N, Arinobu Y, Niiro H, Hotta T, Kang D, Shimono N, Akashi K, Takeuchi T, Horiuchi T.

Rheumatology (Oxford).   kead275.   2023.6

C-reactive protein/albumin ratio is the most significant inflammatory marker in unresectable pancreatic cancer treated with FOLFIRINOX or gemcitabine plus nab-paclitaxel. Reviewed International journal

Shirakawa T, Makiyama A, Shimokawa M, Otsuka T, Shinohara Y, Koga F, Ueda Y, Nakazawa J, Otsu S, Komori A, Arima S, Fukahori M, Taguchi H, Honda T, Shibuki T, Nio K, Ide Y, Ureshino N, Mizuta T, Mitsugi K, Akashi K, Baba E.

Sci Rep.   13 ( 1 )   8815   2023.5

Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance Reviewed International journal

Nakao F, Setoguchi K, Semba Y, Yamauchi T, Nogami J, Sasaki K, Imanaga H, Terasaki T, Miyazaki M, Hirabayashi S, Miyawaki K, Kikushige Y, Masuda T, Akashi K, Maeda T.

Leukemia.   37 ( 5 )   1028 - 1038   2023.5

TIM-3 signaling hijacks the canonical Wnt/β-catenin pathway to maintain cancer stemness in acute myeloid leukemia Reviewed International journal

7 ( 10 )   2053 - 2065   2023.5

Generation of functional oocytes from male mice in vitro Reviewed International journal

Murakami K, Hamazaki N, Hamada N, Nagamatsu G, Okamoto I, Ohta H, Nosaka Y, Ishikura Y, Kitajima TS, Semba Y, Kunisaki Y, Arai F, Akashi K, Saitou M, Kato K, Hayashi K.

Nature.   615 ( 7954 )   900 - 906   2023.3

A preterm newborn-onset juvenile myelomonocytic leukemia-like myeloproliferation with PTPN11 mutation. Reviewed International journal

Yamamoto S, Nakao S, Inoue H, Koga Y, Kojima-Ishii K, Semba Y, Maeda T, Akashi K, Ohga S.

Pediatr Blood Cancer.   70 ( 2 )   e29915   2023.2

Predictors of impaired antibody response after SARS-CoV-2 mRNA vaccination in hematopoietic cell transplant recipients: A Japanese multicenter observational study. Reviewed International journal

Mori Y, Uchida N, Harada T, Katayama Y, Wake A, Iwasaki H, Eto T, Morishige S, Fujisaki T, Ito Y, Kamimura T, Takahashi T, Imamura Y, Tanimoto K, Ishitsuka K, Sugita J, Kawano N, Tanimoto K, Yoshimoto G, Choi I, Hidaka T, Ogawa R, Takamatsu Y, Miyamoto T, Akashi K, Nagafuji K

Am J Hematol.   98 ( 1 )   102 - 111   2023.1

Inhibition of insulin-like growth factor-1 receptor enhances eribulin-induced DNA damage in colorectal cancer. Reviewed International journal

Yoshihiro T, Ariyama H, Yamaguchi K, Imajima T, Yamaga S, Tsuchihashi K, Isobe T, Kusaba H, Akashi K, Baba E.

Cancer Sci.   113 ( 12 )   4207 - 4218   2022.12

Outcome predictors after retransplantation in relapsed acute lymphoblastic leukemia: a multicenter, retrospective study. Reviewed International journal

Mori Y, Sasaki K, Ito Y, Kuriyama T, Ueno T, Kadowaki M, Aoki T, Sugio T, Yoshimoto G, Kato K, Maeda T, Nagafuji K, Akashi K, Miyamoto T; Fukuoka Blood and Marrow Transplantation Group.

Ann Hematol.   100 ( 1 )   197 - 208   2022.11

Macrophages are primed to transdifferentiate into fibroblasts in malignant ascites and pleural effusions. Reviewed International journal

Ito M, Nakano M, Ariyama H, Yamaguchi K, Tanaka R, Semba Y, Sugio T, Miyawaki K, Kikushige Y, Mizuno S, Isobe T, Tanoue K, Taguchi R, Ueno S, Kawano T, Murata M, Baba E, Akashi K.

Cancer Lett.   532   215597   2022.4

A germinal center-associated microenvironmental signature reflects malignant phenotype and outcome of DLBCL. Reviewed International journal

Miyawaki K, Kato K, Sugio T, Sasaki K, Miyoshi H, Semba Y, Kikushige Y, Mori Y, Kunisaki Y, Iwasaki H, Miyamoto T, Kuo FC, Aster JC, Ohshima K, Maeda T, Akashi K.

Blood Adv.   6 ( 7 )   2388 - 2402   2022.4

Genome-wide CRISPR-Cas9 screen identifies rationally designed combination therapies for CRLF2-rearranged Ph-like ALL Reviewed International journal

Sasaki K, Yamauchi T, Semba Y, Nogami J, Imanaga H, Terasaki T, Nakao F, Akahane K, Inukai T, Verhoeyen E, Akashi K, Maeda T.

Blood   139 ( 5 )   748 - 760   2022.3

TNFR2 Signaling Enhances Suppressive Abilities of Human Circulating T Follicular Regulatory Cells. Reviewed International journal

Kawano S, Mitoma H, Inokuchi S, Yamauchi Y, Yokoyama K, Nogami J, Semba Y, Ayano M, Kimoto Y, Akahoshi M, Ono N, Arinobu Y, Akashi K, Horiuchi T, Niiro H.

J Immunol.   208 ( 5 )   1057 - 1065   2022.3

Targeting leukemia-specific dependence on the de novo purine synthesis pathway. Reviewed International journal

Yamauchi T, Miyawaki K, Semba Y, Takahashi M, Izumi Y, Nogami J, Nakao F, Sugio T, Sasaki K, Pinello L, Bauer DE, Bamba T, Akashi K, Maeda T.

Leukemia.   36 ( 2 )   383 - 393   2022.2

Incidence of refractory cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation. Reviewed International journal

Jinnouchi F, Mori Y, Yoshimoto G, Yamauchi T, Nunomura T, Yurino A, Hayashi M, Yuda J, Shima T, Odawara J, Takashima S, Kamezaki K, Kato K, Miyamoto T, Akashi K, Takenaka K.

Int J Hematol.   115 ( 1 )   96 - 106   2022.1

Granulocyte collection by polymorphonuclear cell-targeting apheresis with medium-molecular-weight hydroxyethyl starch. Reviewed International journal

Henzan T, Yamauchi T, Yamanaka I, Sakoda T, Semba Y, Hayashi M, Kikushige Y, Mishima H, Ishimura M, Koga Y, Miyamoto T, Ohga S, Akashi K, Maeda T, Kunisaki Y.

Int J Hematol.   114 ( 6 )   691 - 700   2021.12

Azacitidine for the treatment of patients with relapsed acute myeloid leukemia after allogeneic stem cell transplantation Reviewed International journal

Yoshimoto G, Mori Y, Kato K, Odawara J, Kuriyama T, Ueno T, Obara T, Yurino A, Yoshida S, Ogawa R, Ohno Y, Iwasaki H, Eto T, Akashi K, Miyamoto T.

Leuk Lymphoma.   62 ( 12 )   2939 - 2948   2021.12

Outcomes of methotrexate-associated lymphoproliferative disorders in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs. Reviewed International journal

Harada T, Iwasaki H, Muta T, Urata S, Sakamoto A, Kohno K, Takase K, Miyamura T, Sawabe T, Asaoku H, Oryoji K, Fujisaki T, Mori Y, Yoshimoto G, Ayano M, Mitoma H, Miyamoto T, Niiro H, Yamamoto H, Oshiro Y, Miyoshi H, Ohshima K, Takeshita M, Akashi K, Kato K.

Br J Haematol.   62 ( 12 )   2939 - 2948   2021.12

Circulating CD34+ cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice Reviewed International journal

Saito N, Yamauchi T, Kawano N, Ono R, Yoshida S, Miyamoto T, Kamimura T, Shultz LD, Saito Y, Takenaka K, Shimoda K, Harada M, Akashi K, Ishikawa F.

Int J Hematol.   2021.11

Clinical characteristics, prognostic factors, and outcomes of patients with essential thrombocythemia in Japan: the JSH-MPN-R18 study Reviewed International journal

Hashimoto Y, Ito T, Gotoh A, Nakamae M, Kimura F, Koike M, Kirito K, Wada H, Usuki K, Tanaka T, Mori T, Wakita S, Saito TI, Kada A, Saito AM, Shimoda K, Sugimoto Y, Kurokawa T, Tomita A, Edahiro Y, Akashi K, Matsumura I, Takenaka K, Komatsu N.

Int J Hematol.   2021.11

The membrane-linked adaptor FRS2β fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis Reviewed International journal

118 ( 43 )   :e2103658118.   2021.10

Phase 2 study of axicabtagene ciloleucel in Japanese patients with relapsed or refractory large B-cell lymphoma Reviewed International journal

Kato K, Makita S, Goto H, Kanda J, Fujii N, Shimada K, Akashi K, Izutsu K, Teshima T, Fukuda N, Sumitani T, Sumi H, Shimizu S, Kakurai Y, Yoshikawa K, Tobinai K, Usui N, Hatake K.

Int J Clin Oncol.   2021.10

Improvement in recurring nivolumab-induced pneumonitis with repetitive administration of infliximab in a patient with head and neck cancer: A case report Reviewed International journal

Ueno S, Uenomachi M, Kusaba H, Ito M, Suzuki K, Ohmura H, Tsuchihashi K, Ariyama H, Akashi K, Baba E.

Mol Clin Oncol.   15 ( 4 )   2021 - 2379   2021.10

Optimization of lymphapheresis for manufacturing autologous CAR-T cells. Reviewed International journal

Yamanaka I, Yamauchi T, Henzan T, Sakoda T, Miyamoto K, Mishima H, Ono H, Koga Y, Nakashima Y, Kato K, Miyamoto T, Mizuno S, Ogawa Y, Ohga S, Akashi K, Maeda T, Kunisaki Y.

Int J Hematol.   114 ( 4 )   449 - 458   2021.10

Contrasting specific antibody response to BNT162b2 mRNA vaccination in SARS-CoV-2-naive and previously infected nursing home residents Reviewed International journal

Chong Y, Tani N, Goto T, Yonekawa A, Ikematsu H, Shimono N, Tanaka Y, Akashi K.

J Infect.   S0163-4453 ( 21 )   00508-9.   2021.10

Predictive factors of fetal and maternal pregnancy outcomes in Japanese patients with systemic lupus erythematosus Reviewed International journal

Irino K, Arinobu Y, Ayano M, Kawano S, Kimoto Y, Mitoma H, Akahoshi M, Akashi K, Horiuchi T, Niiro H.

Lupus.   30 ( 10 )   1637 - 1643   2021.9

Association of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus Reviewed International journal

Nakano M, Ayano M, Kushimoto K, Kawano S, Higashioka K, Inokuchi S, Mitoma H, Kimoto Y, Akahoshi M, Ono N, Arinobu Y, Akashi K, Horiuchi T, Niiro H.

Sci Rep.   11 ( 1 )   16162   2021.8

Azacitidine for the treatment of patients with relapsed acute myeloid leukemia after allogeneic stem cell transplantation Reviewed International journal

Yoshimoto G, Mori Y, Kato K, Odawara J, Kuriyama T, Ueno T, Obara T, Yurino A, Yoshida S, Ogawa R, Ohno Y, Iwasaki H, Eto T, Akashi K, Miyamoto T.

Leuk Lymphoma.   62 ( 12 )   2939 - 2948   2021.7

Use of 18 F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography to successfully diagnose central nervous system vasculitis in systemic lupus erythematosus and antiphospholipid syndrome: a case report Reviewed International journal

Mishima K, Ayano M, Nishida T, Tatsutani T, Inokuchi S, Kimoto Y, Mitoma H, Akahoshi M, Arinobu Y, Akashi K, Horiuchi T, Niiro H.

Mod Rheumatol Case Rep.   5 ( 2 )   278 - 284   2021.7

Outcomes of methotrexate-associated lymphoproliferative disorders in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs Reviewed International journal

Harada T, Iwasaki H, Muta T, Urata S, Sakamoto A, Kohno K, Takase K, Miyamura T, Sawabe T, Asaoku H, Oryoji K, Fujisaki T, Mori Y, Yoshimoto G, Ayano M, Mitoma H, Miyamoto T, Niiro H, Yamamoto H, Oshiro Y, Miyoshi H, Ohshima K, Takeshita M, Akashi K, Kato K.

Br J Haematol.   194 ( 1 )   101 - 110   2021.7

Increased Proportion of CD226 + B Cells Is Associated With the Disease Activity and Prognosis of Systemic Lupus Erythematosus Reviewed International journal

Nakano M, Ayano M, Kushimoto K, Kawano S, Higashioka K, Inokuchi S, Mitoma H, Kimoto Y, Akahoshi M, Ono N, Arinobu Y, Akashi K, Horiuchi T, Niiro H.

Front Immunol.   12   713225.   2021.7

Prominent PD-L1-positive M2 macrophage infiltration in gastric cancer with hyper-progression after anti-PD-1 therapy: A case report Reviewed International journal

Yamaguchi K, Tsuchihashi K, Tsuji K, Kito Y, Tanoue K, Ohmura H, Ito M, Isobe T, Ariyama H, Kusaba H, Akashi K, Baba E.

Medicine (Baltimore).   100 ( 19 )   e25773.   2021.5

Reduced dose of posttransplant cyclophosphamide in HLA-haploidentical peripheral blood stem cell transplantation. Reviewed International journal

Sugita J, Kamimura T, Ishikawa T, Ota S, Eto T, Kuroha T, Miyazaki Y, Kumagai H, Matsuo K, Akashi K, Taniguchi S, Harada M, Teshima T.

Bone Marrow Transplant.   56 ( 3 )   596 - 604   2021.5

Efficacy of prophylactic letermovir for cytomegalovirus reactivation in hematopoietic cell transplantation: a multicenter real-world data . Reviewed International journal

Mori Y, Jinnouchi F, Takenaka K, Aoki T, Kuriyama T, Kadowaki M, Odawara J, Ueno T, Kohno K, Harada T, Yoshimoto G, Takase K, Henzan H, Kato K, Ito Y, Kamimura T, Ohno Y, Ogawa R, Eto T, Nagafuji K, Akashi K, Miyamoto T.

Bone Marrow Transplant.   56 ( 4 )   853 - 862   2021.4

Activation of caspase-1 is mediated by stimulation of interferon genes and NLR family pyrin domain containing 3 in monocytes of active systemic lupus erythematosus Reviewed International journal

Inokuchi S, Mitoma H, Kawano S, Ayano M, Kimoto Y, Akahoshi M, Arinobu Y, Akashi K, Horiuchi T, Niiro H.

Clin Exp Rheumatol.   2021.3

Reduced dose of posttransplant cyclophosphamide in HLA-haploidentical peripheral blood stem cell transplantation. Reviewed International journal

Sugita J, Kamimura T, Ishikawa T, Ota S, Eto T, Kuroha T, Miyazaki Y, Kumagai H, Matsuo K, Akashi K, Taniguchi S, Harada M, Teshima T.

Bone Marrow Transplant.   56 ( 3 )   596 - 604   2021.3

Genetic testing and serological screening for SARS-CoV-2 infection in a COVID-19 outbreak in a nursing facility in Japan Reviewed International journal

Chong Y, Tani N, Ikematsu H, Terazawa N, Nakashima H, Shimono N, Akashi K, Tanaka Y.

BMC Infect Dis.   21 ( 1 )   263   2021.3

Type 1 helper T cells generate CXCL9/10-producing T-bet + effector B cells potentially involved in the pathogenesis of rheumatoid arthritis. Reviewed International journal

Nakayama T, Yoshimura M, Higashioka K, Miyawaki K, Ota Y, Ayano M, Kimoto Y, Mitoma H, Ono N, Arinobu Y, Kikukawa M, Yamada H, Akashi K, Horiuchi T, Niiro H.

Cell Immunol.   360   104263 - 104263   2021.2

Predictive impact of C-reactive protein to albumin ratio for recurrent or metastatic head and neck squamous cell carcinoma receiving nivolumab Reviewed International journal

Tanoue K, Tamura S, Kusaba H, Shinohara Y, Ito M, Tsuchihashi K, Shirakawa T, Otsuka T, Ohmura H, Isobe T, Ariyama H, Koreishi S, Matsushita Y, Shimokawa H, Tanaka R, Mitsugi K, Akashi K, Baba E.

Sci Rep.   11 ( 1 )   2741   2021.2

Type 1 helper T cells generate CXCL9/10-producing T-bet + effector B cells potentially involved in the pathogenesis of rheumatoid arthritis Reviewed International journal

Nakayama T, Yoshimura M, Higashioka K, Miyawaki K, Ota Y, Ayano M, Kimoto Y, Mitoma H, Ono N, Arinobu Y, Kikukawa M, Yamada H, Akashi K, Horiuchi T, Niiro H.

Cell Immunol.   360   104263   2021.2

B cell receptor signaling related to resistance to Helicobacter pylori eradication therapy in gastric diffuse large B cell lymphoma. Reviewed International journal

Torisu T, Kawano S, Miyawaki K, Yamamoto H, Ihara Y, Matsuno Y, Torisu K, Sugio T, Sasaki K, Shimakawa T, Kato K, Akashi K, Nakamura S, Kitazono T.

Hematol Oncol.   39 ( 1 )   145 - 147   2021.2

Low-dose anti-thymocyte globulin for GVHD prophylaxis in HLA-matched allogeneic peripheral blood stem cell transplantation. Reviewed International journal

Shiratori S, Sugita J, Ota S, Kasahara S, Ishikawa J, Tachibana T, Hayashi Y, Yoshimoto G, Eto T, Iwasaki H, Harada M, Matsuo K, Teshima T; Japan Study Group for Cell Therapy and Transplantation (JSCT).

Bone Marrow Transplant.   56 ( 1 )   129 - 136   2021.1

Outcome predictors after retransplantation in relapsed acute lymphoblastic leukemia: a multicenter, retrospective study Reviewed International journal

Mori Y, Sasaki K, Ito Y, Kuriyama T, Ueno T, Kadowaki M, Aoki T, Sugio T, Yoshimoto G, Kato K, Maeda T, Nagafuji K, Akashi K, Miyamoto T; Fukuoka Blood and Marrow Transplantation Group.

Ann Hematol.   100 ( 1 )   197 - 208   2021.1

Clinical significance of SARS-CoV-2-specific IgG detection with a rapid antibody kit for COVID-19 patients. Reviewed International journal

Chong Y, Ikematsu H, Tani N, Arimizu Y, Watanabe H, Fukamachi Y, Yonekawa A, Iwasaka S, Nishida R, Eriguchi Y, Miyake N, Shimoda S, Nagasaki Y, Shimono N, Akashi K.

Influenza Other Respir Viruses.   15 ( 1 )   13 - 18   2021.1

Eribulin as a first-line treatment for soft tissue sarcoma patients with contraindications for doxorubicin. Reviewed International journal

Tsuchihashi K, Kusaba H, Yoshihiro T, Fujiwara T, Setsu N, Endo M, Matsumoto Y, Imajima T, Shinohara Y, Ito M, Yamaga S, Tanoue K, Arimizu K, Ohmura H, Hanamura F, Yamaguchi K, Isobe T, Ariyama H, Nakashima Y, Akashi K, Baba E.

Sci Rep.   10 ( 1 )   20896 - 20896   2020.12

Transfer learning efficiently maps bone marrow cell types from mouse to human using single-cell RNA sequencing. Reviewed International journal

Stumpf PS, Du X, Imanishi H, Kunisaki Y, Semba Y, Noble T, Smith RCG, Rose-Zerili M, West JJ, Oreffo ROC, Farrahi K, Niranjan M, Akashi K, Arai F, MacArthur BD.

Commun Biol.   3 ( 1 )   376 - 736   2020.12

Phase I study of duvelisib in Japanese patients with relapsed or refractory lymphoma. Reviewed International journal

Izutsu K, Kato K, Kiyoi H, Yamamoto G, Shimada K, Akashi K.

Int J Hematol.   112 ( 4 )   504 - 509   2020.10

Myeloablative intravenous busulfan-containing regimens for allo-HSCT in AML or MDS patients over 54 years old: combined results of three phase II studies. Reviewed International journal

Uchida N, Matsumoto K, Sakura T, Hidaka M, Miyamoto T, Eto T, Maeda Y, Murayama T, Fujishima N, Yoshimoto G, Morita K, Kishimoto J, Teshima T, Taniguchi S, Yamashita T, Mori SI, Akashi K, Harada

Int J Hematol.   112 ( 4 )   510 - 523   2020.10

Mitochondrial Protein Synthesis Is Essential for Terminal Differentiation of CD45- TER119-Erythroid and Lymphoid Progenitors. iScience. Reviewed International journal

Gotoh K, Kunisaki Y, Mizuguchi S, Setoyama D, Hosokawa K, Yao H, Nakashima Y, Yagi M, Uchiumi T, Semba Y, Nogami J, Akashi K, Arai F, Kang D.

iScience.   23 ( 11 )   101654 - 101654   2020.10

RNA N6-methyladenosine demethylase FTO regulates PD-L1 expression in colon cancer cells. Reviewed International journal

Tsuruta N, Tsuchihashi K, Ohmura H, Yamaguchi K, Ito M, Ariyama H, Kusaba H, Akashi K, Baba E.

Biochem Biophys Res Commun.   530 ( 1 )   235 - 239   2020.9

Correction to: Measurable residual disease after the first consolidation predicts the outcomes of patients with acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy. Reviewed International journal

Henzan H, Takase K, Kamimura T, Mori Y, Yoshimoto G, Iwasaki H, Nagafuji K, Ogawa R, Eto T, Uchida N, Fujisaki T, Kato K, Minami M, Kikushige Y, Akashi K, Miyamoto T; Fukuoka Blood & Marrow Transplantation Group (FBMTG).

Int J Hematol.   112 ( 3 )   431 - 432   2020.9

Measurable residual disease after the first consolidation predicts the outcomes of patients with acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy. Reviewed International journal

Henzan H, Takase K, Kamimura T, Mori Y, Yoshimoto G, Iwasaki H, Nagafuji K, Ogawa R, Eto T, Uchida N, Fujisaki T, Kato K, Minami M, Kikushige Y, Akashi K, Miyamoto T; Fukuoka Blood & Marrow Transplantation Group (FBMTG).

Int J Hematol.   112 ( 3 )   349 - 360   2020.9

Impaired deformability and association with density distribution of erythrocytes in patients with type 2 diabetes mellitus under treatment. Reviewed International journal

Arita T, Maruyama T, Yokoyama T, Hieda M, Fukata M, Fujino T, Mawatari S, Akashi K.

Clin Hemorheol Microcirc.   76 ( 1 )   73 - 83   2020.9

HTLV-1 seropositive patients with lung cancer treated with PD-1 inhibitors. Reviewed International journal

Yoneshima Y, Kato K, Minami H, Ikeda M, Watanabe H, Yoshimoto G, Miyamoto T, Akashi K, Nakanishi Y, Okamoto I.

Cancer Sci.   111 ( 9 )   3395 - 3396   2020.9

Efficacy and safety of tisagenlecleucel in Japanese adult patients with relapsed/refractory diffuse large B-cell lymphoma. Reviewed International journal

Goto H, Makita S, Kato K, Tokushige K, Fujita T, Akashi K, Izutsu K, Teshima T.

Int J Clin Oncol.   25 ( 9 )   1736 - 1743   2020.9

Methotrexate Enhances Apoptosis of Transmembrane TNF-Expressing Cells Treated With Anti-TNF Agents. Reviewed International journal

Wang Q, Oryoji D, Mitoma H, Kimoto Y, Koyanagi M, Yokoyama K, Ayano M, Akahoshi M, Arinobu Y, Niiro H, Akashi K, Horiuchi T.

Front Immunol.   11   2042 - 2042   2020.8

Combination of CD47 and signal-regulatory protein-α constituting the "don't eat me signal" is a prognostic factor in diffuse large B-cell lymphoma. Reviewed International journal

111 ( 7 )   2608 - 2619   2020.7

Effects of stem cell transplantation in patients with peripheral T-cell lymphoma not otherwise specified and angioimmunoblastic T-cell lymphoma. Reviewed International journal

Yamasaki S, Yoshida S, Kato K, Choi I, Imamura Y, Kohno K, Henzan H, Tanimoto K, Ogawa R, Suehiro Y, Miyamoto T, Eto T, Ohshima K, Akashi K, Iwasaki H; Fukuoka Blood and Marrow Transplantation Group.

Int J Hematol.   112 ( 1 )   74 - 83   2020.7

Tyrosine kinase inhibitors induce alternative spliced BCR-ABLIns35bp variant via inhibition of RNA polymerase II on genomic BCR-ABL. Reviewed International journal

Yuda J, Odawara J, Minami M, Muta T, Kohno K, Tanimoto K, Eto T, Shima T, Kikushige Y, Kato K, Takenaka K, Iwasaki H, Minami Y, Ohkawa Y, Akashi K, Miyamoto T.

Cancer Sci.   111 ( 7 )   2361 - 2373   2020.7

Association of circulating SLAMF7+Tfh1 cells with IgG4 levels in patients with IgG4-related disease. Reviewed International journal

Higashioka K, Ota Y, Maehara T, Moriyama M, Ayano M, Mitoma H, Akahoshi M, Arinobu Y, Horiuchi T, Nakamura S, Akashi K, Niiro H.

BMC Immunol.   21 ( 1 )   31   2020.6

OX40 and LAG3 are associated with better prognosis in advanced gastric cancer patients treated with anti-programmed death-1 antibody. Reviewed International journal

Ohmura H, Yamaguchi K, Hanamura F, Ito M, Makiyama A, Uchino K, Shimokawa H, Tamura S, Esaki T, Mitsugi K, Shibata Y, Oda H, Tsuchihashi K, Ariyama H, Kusaba H, Oda Y, Akashi K, Baba E.

Br J Cancer.   135 ( 19 )   1661 - 1672   2020.5

Phase I/II study of bortezomib, lenalidomide, and dexamethasone treatment for relapsed and refractory multiple myeloma. Reviewed International journal

Mori Y, Choi I, Yoshimoto G, Muta T, Yamasaki S, Tanimoto K, Kamimura T, Iwasaki H, Ogawa R, Akashi K, Miyamoto T; Fukuoka Blood and Marrow Transplantation Group

Int J Hematol.   111 ( 5 )   673 - 680   2020.5

Methylation of drug resistance-related genes in chemotherapy-sensitive Epstein-Barr virus-associated gastric cancer. Reviewed International journal

Ohmura H, Ito M, Uchino K, Okada C, Tanishima S, Yamada Y, Momosaki S, Komoda M, Kuwayama M, Yamaguchi K, Okumura Y, Nakano M, Tsuchihashi K, Isobe T, Ariyama H, Kusaba H, Oda Y, Akashi K, Baba E.

FEBS Open Bio.   10 ( 1 )   147 - 157   2020.5

A human SIRPA knock-in xenograft mouse model to study human hematopoietic and cancer stem cells. Reviewed International journal

Jinnouchi F, Yamauchi T, Yurino A, Nunomura T, Nakano M, Iwamoto C, Obara T, Miyawaki K, Kikushige Y, Kato K, Maeda T, Miyamoto T, Baba E, Akashi K, Takenaka K.

Blood.   135 ( 19 )   1661 - 1672   2020.5

Establishment of a human SIRPA knock-in xenograft mouse model to study human hematopoietic and cancer stem cells. Reviewed International journal

Jinnouchi F, Yamauchi T, Yurino A, Nunomura T, Miyawaki K, Kikushige Y, Kato K, Maeda T, Miyamoto T, Baba E, Akashi K, Takenaka K.

Blood   135 ( 19 )   1661 - 1672   2020.5

Acute and Chronic Effects of Cancer Drugs on the Cardiovascular System. Reviewed International journal

Moriyama S, Fukata M, Kusaba H, Maruyama T, Akashi K.

Heart Fail Clin.   16 ( 2 )   231 - 241   2020.4

Treatment outcomes of chronic-phase chronic myeloid leukemia with resistance and/or intolerance to a 1st-line tyrosine kinase inhibitor in Japan: the results of the New TARGET study 2nd-line. Reviewed International journal

Sakurai M, Okamoto S, Matsumura I, Murakami S, Takizawa M, Waki M, Hirano D, Watanabe-Nakaseko R, Kobayashi N, Iino M, Mitsui H, Ishikawa Y, Takahashi N, Kawaguchi T, Suzuki R, Yamamoto K, Kizaki M, Ohnishi K, Naoe T, Akashi K; New TARGET investigators.

Int J Hematol.   111 ( 6 )   812 - 825   2020.3

OX40 and LAG3 are associated with better prognosis in advanced gastric cancer patients treated with anti-programmed death-1 antibody. Reviewed International journal

Ohmura H, Yamaguchi K, Hanamura F, Ito M, Makiyama A, Uchino K, Shimokawa H, Tamura S, Esaki T, Mitsugi K, Shibata Y, Oda H, Tsuchihashi K, Ariyama H, Kusaba H, Oda Y, Akashi K, Baba E.

Br J Cancer.   122 ( 10 )   1507 - 1517   2020.3

Homeostatic Milieu Induces Production of Deoxyribonuclease 1-like 3 from Myeloid Cells. Reviewed International journal

Inokuchi S, Mitoma H, Kawano S, Nakano S, Ayano M, Kimoto Y, Akahoshi M, Arinobu Y, Tsukamoto H, Akashi K, Horiuchi T, Niiro H.

J Immunol.   204 ( 8 )   2088 - 2097   2020.3

Shoulder ultrasound and serum lactate dehydrogenase predict inadequate response to glucocorticoid treatment in patients with polymyalgia rheumatica. Reviewed International journal

Ayano M, Arinobu Y, Tsukamoto H, Ota SI, Misaki K, Nishimura K, Kimoto Y, Mitoma H, Akahoshi M, Akashi K, Horiuchi T, Niiro H.

Rheumatol Int.   40 ( 7 )   1101 - 1109   2020.2

Helper T cell-dominant tertiary lymphoid structures are associated with disease relapse of advanced colorectal cancer. Reviewed International journal

Yamaguchi K, Ito M, Ohmura H, Hanamura F, Nakano M, Tsuchihashi K, Nagai S, Ariyama H, Kusaba H, Yamamoto H, Oda Y, Nakamura M, Akashi K, Baba E.

Oncoimmunology.   9 ( 1 )   1724763 - 1724763   2020.2

Methylation of drug resistance-related genes in chemotherapy-sensitive Epstein-Barr virus-associated gastric cancer. Reviewed International journal

Ohmura H, Ito M, Uchino K, Okada C, Tanishima S, Yamada Y, Momosaki S, Komoda M, Kuwayama M, Yamaguchi K, Okumura Y, Nakano M, Tsuchihashi K, Isobe T, Ariyama H, Kusaba H, Oda Y, Akashi K, Baba E.

FEBS Open Bio.   10 ( 1 )   147 - 157   2020.1

Myeloid differentiation factor 88 signaling in donor T cells accelerates graft-versus-host disease. Reviewed International journal

Matsuoka S, Hashimoto D, Kadowaki M, Ohigashi H, Hayase E, Yokoyama E, Hasegawa Y, Tateno T, Chen X, Aoyama K, Oka H, Onozawa M, Takeda K, Akashi K, Teshima T.

Haematologica.   105 ( 1 )   226 - 234   2020.1

Association of circulating SLAMF7+Tfh1 cells with IgG4 levels in patients with IgG4-related disease. Reviewed International journal

Higashioka K, Ota Y, Maehara T, Moriyama M, Ayano M, Mitoma H, Akahoshi M, Arinobu Y, Horiuchi T, Nakamura S, Akashi K, Niiro H.

BMC Immunol.   21 ( 1 )   31 - 31   2020.1

Cyclophosphamide-Induced Tolerance in Allogeneic Transplantation: From Basic Studies to Clinical Application. Reviewed International journal

Kato K, Takeuchi A, Akashi K, Eto M.

Front Immunol.   10   3138 - 3138   2020.1

Phase I/II study of bortezomib, lenalidomide, and dexamethasone treatment for relapsed and refractory multiple myeloma. Reviewed International journal

Mori Y, Choi I, Yoshimoto G, Muta T, Yamasaki S, Tanimoto K, Kamimura T, Iwasaki H, Ogawa R, Akashi K, Miyamoto T; Fukuoka Blood and Marrow Transplantation Group.

Int J Hematol.   111 ( 5 )   673 - 680   2020.1

Cessation of nilotinib in patients with chronic myelogenous leukemia who have maintained deep molecular responses for 2 years: a multicenter phase 2 trial, stop nilotinib (NILSt). Reviewed International journal

Nagafuji K, Matsumura I, Shimose T, Kawaguchi T, Kuroda J, Nakamae H, Miyamoto T, Kadowaki N, Ishikawa J, Imamura Y, Yamazaki H, Akashi K, Kanakura Y.

Int J Hematol.   110 ( 6 )   675 - 682   2019.12

Comparison of calcineurin inhibitors in combination with conventional methotrexate, reduced methotrexate, or mycophenolate mofetil for prophylaxis of graft-versus-host disease after umbilical cord blood transplantation. Reviewed International journal

Yoshida S, Ohno Y, Nagafuji K, Yoshimoto G, Sugio T, Kamimura T, Ohta T, Takase K, Henzan H, Muta T, Iwasaki H, Ogawa R, Eto T, Akashi K, Miyamoto T.

Ann Hematol.   98 ( 11 )   2579 - 2591   2019.11

Prospective evaluation of minimal residual disease monitoring to predict prognosis of adult patients with Ph-negative acute lymphoblastic leukemia. Reviewed International journal

Nagafuji K, Miyamoto T, Eto T, Ogawa R, Okumura H, Takase K, Kawano N, Miyazaki Y, Fujisaki T, Wake A, Ohno Y, Kurokawa T, Kamimura T, Takamatsu Y, Yokota S, Akashi K.

Eur J Haematol. 2   103 ( 3 )   164 - 171   2019.9

Anti-GPRC5D/CD3 Bispecific T-Cell-Redirecting Antibody for the Treatment of Multiple Myeloma. Reviewed International journal

Kodama T, Kochi Y, Nakai W, Mizuno H, Baba T, Habu K, Sawada N, Tsunoda H, Shima T, Miyawaki K, Kikushige Y, Mori Y, Miyamoto T, Maeda T, Akashi K.

Mol Cancer Ther.   18 ( 9 )   1555 - 1564   2019.9

Safety and Seropositivity after Live Attenuated Vaccine in Adult Patients Receiving Hematopoietic Stem Cell Transplantation. Reviewed International journal

Aoki T, Kamimura T, Yoshida S, Mori Y, Kadowaki M, Kohno K, Ishihara D, Urata S, Sugio T, Kamezaki K, Kato K, Ito Y, Eto T, Akashi K, Miyamoto T.

Biol Blood Marrow Transplant.   24 ( 8 )   1576 - 1585   2019.8

Bortezomib-based strategy with autologous stem cell transplantation for newly diagnosed multiple myeloma: a phase II study by the Japan Study Group for Cell Therapy and Transplantation (JSCT-MM12). Reviewed International journal

Sunami K, Matsumoto M, Fuchida SI, Omoto E, Takamatsu H, Adachi Y, Choi I, Fujishima N, Kiguchi T, Miyamoto T, Maeda A, Suzumiya J, Yamamura R, Nagafuji K, Nakazato T, Kuroda Y, Yujiri T, Takamatsu Y, Harada M, Akashi K.

Int J Clin Oncol.   24 ( 8 )   966 - 975   2019.8

CCR6+ group 3 innate lymphoid cells accumulate in inflamed joints in rheumatoid arthritis and produce Th17 cytokines. Reviewed International journal

Takaki-Kuwahara A, Arinobu Y, Miyawaki K, Yamada H, Tsuzuki H, Irino K, Ayano M, Kimoto Y, Mitoma H, Akahoshi M, Tsukamoto H, Horiuchi T, Niiro H, Akashi K.

Arthritis Res Ther.   21 ( 1 )   198 - 198   2019.8

Clinicopathological features of HCV-positive splenic diffuse large B cell lymphoma. Reviewed International journal

Shimono J, Miyoshi H, Arakawa F, Yamada K, Sugio T, Miyawaki K, Eto T, Miyagishima T, Kato K, Nagafuji K, Akashi K, Teshima T, Ohshima K.

Ann Hematol.   98 ( 5 )   1197 - 1207   2019.5

Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia. Reviewed International journal

Elbadry MI, Mizumaki H, Hosokawa K, Espinoza JL, Nakagawa N, Chonabayashi K, Yoshida Y, Katagiri T, Hosomichi K, Zaimoku Y, Imi T, Nguyen MAT, Fujii Y, Tajima A, Ogawa S, Takenaka K, Akashi K, Nakao S.

Haematologica.   2019.3

Successful rescue transplantation with desensitization procedure after primary graft failure due to donor-specific antibody. Reviewed International journal

Minami M, Matsushima T, Mori Y, Ishihara D, Jinnnouchi F, Takenaka K, Henzan T, Yoshimoto G, Numata A, Kato K, Maeda T, Miyamoto T, Akashi K.

Bone Marrow Transplant.   54 ( 8 )   1374 - 1376   2019.2

Hypoalbuminemia for the prediction of venous thromboembolism and treatment of direct oral anticoagulants in metastatic gastric cancer patients. Reviewed International journal

Takayoshi K, Kusaba H, Aikawa T, Koreishi S, Sagara K, Nakano M, Komoda M, Kono M, Fukata M, Arita T, Esaki T, Akashi K, Baba E.

Gastric Cancer.   22 ( 5 )   988 - 998   2019.2

Serum levels of fibroblast growth factor-2 distinguish Takayasu arteritis from giant cell arteritis independent of age at diagnosis. International journal

Fukui S, Kuwahara-Takaki A, Ono N, Sato S, Koga T, Kawashiri SY, Iwanaga N, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Migita K, Arinobu Y, Niiro H, Tada Y, Akashi K, Maeda T, Kawakami A.

Sci Rep.   9 ( 1 )   688   2019.1

Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells. Reviewed International journal

Tominaga K, Minato H, Murayama T, Sasahara A, Nishimura T, Kiyokawa E, Kanauchi H, Shimizu S, Sato A, Nishioka K, Tsuji EI, Yano M, Ogawa T, Ishii H, Mori M, Akashi K, Okamoto K, Tanabe M, Tada KI, Tojo A, Gotoh N.

Proc Natl Acad Sci U S A.   116 ( 2 )   625 - 630   2019.1

Efficacy and safety of ramucirumab plus modified FOLFIRI for metastatic colorectal cancer. Reviewed International journal

Yoshihiro T, Kusaba H, Makiyama A, Kobayashi K, Uenomachi M, Ito M, Doi Y, Mitsugi K, Aikawa T, Takayoshi K, Esaki T, Shimokawa H, Tsuchihashi K, Ariyama H, Akashi K, Baba E.

Int J Clin Oncol.   24 ( 5 )   508 - 515   2019.1

CD34-selected versus unmanipulated autologous haematopoietic stem cell transplantation in the treatment of severe systemic sclerosis: a post hoc analysis of a phase I/II clinical trial conducted in Japan. Reviewed International journal

Ayano M, Tsukamoto H, Mitoma H, Kimoto Y, Akahoshi M, Arinobu Y, Miyamoto T, Horiuchi T, Niiro H, Nagafuji K, Harada M, Akashi K.

Arthritis Res Ther.   21 ( 1 )   30   2019.1

Recovery from left ventricular dysfunction was associated with the early introduction of heart failure medical treatment in cancer patients with anthracycline-induced cardiotoxicity. Reviewed International journal

Ohtani K, Fujino T, Ide T, Funakoshi K, Sakamoto I, Hiasa KI, Higo T, Kamezaki K, Akashi K, Tsutsui H.

Clin Res Cardiol.   108 ( 6 )   600 - 611   2018.10

Long-term efficacy of infliximab treatment and the predictors of treatment outcomes in patients with refractory uveitis associated with Behçet's disease. Reviewed International journal

5 ( 1 )   9 - 15   2018.3

α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice. Reviewed International journal

125 ( 19 )   3014 - 3023   2015.5

The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment. Reviewed

koichi akashi

Exp Hematol   42   163 - 171   2013.11

Contribution of bone marrow-derived hematopoietic stem/progenitor cells to the generation of donor-marker(+) cardiomyocytes in vivo.

koichi akashi

PLoS One 8   8   2013.5

Antibiotic rotation for febrile neutropenic patients with hematological malignancies: clinical significance of antibiotic heterogeneity. Reviewed

koichi akashi

PLoS One 8   8   2013.1

FLT3-ITD upregulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation.

Yoshimoto G, Miyamoto T, Tabrizi SJ, Iino T, Rocnik JL, Kikushige Y, Mori Y, Shima T, Iwasaki H, Takenaka K, Nagafuji K, Mizuno SI, Niiro H, Gilliland GD, Akashi K.

Blood   114 ( 24 )   2010.10

Identification of the human eosinophil lineage-committed progenitor: revision of phenotypic definition of the human common myeloid progenitor. International journal

Mori Y, Iwasaki H, Kohno K, Yoshimoto G, Kikushige Y, Okeda A, Uike N, Niiro H, Takenaka K, Nagafuji K, Miyamoto T, Harada M, Takatsu K, Akashi K.

2009.10

Infectious complications in patients receiving autologous CD34-selected hematopoietic stem cell transplantation for severe autoimmune diseases. International journal

Kohno K, Nagafuji K, Tsukamoto H, Horiuchi T, Takase K, Aoki K, Henzan H, Kamezaki K, Takenaka K, Miyamoto T, Teshima T, Harada M, Akashi K.

Transplant Infect Dis   11 ( 4 )   2009.10

T cell leukemia/lymphoma 1 and galectin-1 regulate survival/cell death pathways in human naive and IgM+ memory B cells through altering balances in Bcl-2 family proteins. International journal

Tabrizi, S.J., H. Niiro, M. Masui, G. Yoshimoto, T. Iino, Y. Kikushige, T. Wakasaki, E. Baba, S. Shimoda, T. Miyamoto, T. Hara, and K. Akashi.

J Immunol   2009.2

Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen-presenting cells. International journal

Koyama, M., D. Hashimoto, K. Aoyama, K.I. Matsuoka, K. Karube, H. Niiro, M. Harada, M. Tanimoto, K. Akashi, and T. Teshima.

Blood   2009.2

Identification of the human eosinophil lineage-committed progenitor: revision of phenotypic definition of the human common myeloid progenitor. International journal

Mori, Y., H. Iwasaki, K. Kohno, G. Yoshimoto, Y. Kikushige, A. Okeda, N. Uike, H. Niiro, K. Takenaka, K. Nagafuji, T. Miyamoto, M. Harada, K. Takatsu, and K. Akashi.

J Exp Med   2009.1

Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival. International journal

Kikushige Y, Yoshimoto G, Miyamoto T, Iino T, Mori Y, Iwasaki H, Niiro H, Takenaka K, Nagafuji K, Harada M, Ishikawa F, Akashi K.

J Immunol   2008.6

Antagonism of FOG-1 and GATA foctors in fate choice for the mast cell lineage. International journal

Cantor AB, Iwasaki H, Arinobu Y, Moran TB, Shigematsu H, Sullivan MR, Akashi K, Orkin SH.

J Exp Med   2008.3

Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Reviewed International journal

Ishikawa F, Yoshida S, Saito Y, Hijikata A, Kitamura H, Tanaka S, Nakamura R, Tanaka T, Tomiyama H, Saito N, Fukata M, Miyamoto T, Lyons B, Ohshima K, Uchida N, Taniguchi S, Ohara O, Akashi K, Harada M, Shultz LD:

Nat Biotech   2007.11

Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myelo-erythroid and myelo-lymphoid lineages. Reviewed International journal

Arinobu Y, Mizuno S-I, Chong Y, Shigematsu H, Iino T, Iwasaki H, Graf T, Mayfield R, Chan S, Kastner P, Akashi K:

Cell Stem Cell   2007.10

In vivo repopulation of cytoplasmically gene transferred hematopoietic cells by temperature-sensitive mutant of recombinant Sendai viral vector. Reviewed International journal

Yoshida K, Yonemitsu Y, Tanaka S, Yoshida S, Shibata S, Kondo H, Okano S, Ishikawa F, Akashi K, Inoue M, Hasegawa M, Sueishi K:

Biochem Biophys Res Commun   2007.9

The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation. Reviewed International journal

Feinberg MW, Wara AK, Cao Z, Lebedeva MA, Rosenbauer F, Iwasaki H, Hirai H, Katz JP, Haspel RL, Gray S, Akashi K, Segre J, Kaestner KH, Tenen DG, Jain MK:

EMBO J   2007.9

Distinctive Expression of Myelomonocytic markers and down-regulation of CD34 in acute myelogenous leukaemia with FLT3 tandem duplication and nucleophosmin mutation. Reviewed International journal

Mori Y, Yoshimoto G, Kumano T, Miyamoto T, Iino T, Takenaka K, Iwasaki H, Harada N, Kinukawa N, Nagafuji K, Teshima T, Shimoda K, Akashi K, Harada M:

Eur J Haematol   2007.7

The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways. Reviewed International journal

Ishikawa F, Niiro H, Iino T, Yoshida S, Saito N, Onohara S, Miyamoto T, Minagawa H, Fujii SI, Shultz LD, Harada M, Akashi K:

Blood.   2007.7

Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Reviewed International journal

Maeda T, Merghoub T, Hobbs RM, Dong L, Maeda M, Zakrzewski J, van den Brink MR, Zelent A, Shigematsu H, Akashi K, Teruya J, Cattoretti G, Pandolfi PP:

Science   2007.5

Ott1(Rbm15) has pleiotropic roles in hematopoietic development. Reviewed International journal

Raffel GD, Mercher T, Shigematsu H, Williams IR, Cullen DE, Akashi K, Bernard OA, Gilliland DG:

Proc Natl Acad Sci USA   2007.4

Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue. Reviewed International journal

Alcaide P, Jones TG, Lord GM, Glimcher LH, Hallgren J, Akashi K, Patterson A, Gurish MA, Luscinskas FW:

J Exp Med   2007.2

Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1. Reviewed International journal

Rosenbauer F, Owens BM, Yu L, Tumang JR, Steidl U, Kutok JL, Clayton LK, Wagner K, Scheller M, Iwasaki H, Liu C, Hackanson B, Akashi K, Leutz A, Rothstein TL, Plass C, and Tenen DG:

Nat Genet   2006.11

The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. Reviewed International journal

Iwasaki H, Mizuno S, Arinobu Y, Ozawa H, Mori Y, Shigematsu H, Takatsu K, Tenen DG and Akashi K:

Genes Dev   2006.11

Essential role for cyclin d3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes. Reviewed International journal

Sicinska E, Lee YM, Gits J, Shigematsu H, Yu Q, Rebel VI, Geng Y, Marshall CJ, Akashi K, Dorfman DM, Touw IP, Sicinski P.

Mol Cell Biol   2006.9

C/EBPbeta is required for 'emergency' granulopoiesis. Reviewed International journal

Hirai H, Zhang P, Dayaram T, Hetherington CJ, Mizuno S, Imanishi J, Akashi K and Tenen DG:

Nat Immunol   2006.6

Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease. Reviewed International journal

Chan IT, Kutok JL, Williams IR, Cohen S, Moore S, Shigematsu H, Ley TJ, Akashi K, Le Beau MM, Gilliland DG:

Blood   2006.5

Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Reviewed International journal

Arinobu Y, Iwasaki H, Gurish MF, Mizuno S, Shigematsu H, Ozawa H, Tenen DG, Austen KF, Akashi K:

Proc Natl Acad Sci USA   102 ( 50 )   18105 - 18110   2005.12

Efficient engraftment of primary adult T-cell leukemia cells in newborn NOD/SCID/beta2-microglobulin(null) mice. Reviewed International journal

Kawano N, Ishikawa F, Shimoda K, Yasukawa M, Nagafuji K, Miyamoto T, Baba E, Tanaka T, Yamasaki S, Gondo H, Otsuka T, Ohshima K, Shultz LD, Akashi K, Harada M:

Leukemia   19 ( 8 )   1384 - 1390   2005.8

Distinct and indispensable roles of PU.1 in maintenance of stem cells and their differentiaation. Reviewed International journal

Iwasaki H,Iwasaki-Arai J,Somoza C,Duprez EA,Geary K,Zhang P,Dayaram T,Fenyus M,Huettner CS,Murray R,Tenen DG,and Akashi K.

Blood   2005.5

Development of functional human blood and immune systems in NOD/SCID/IL2 receptor (gamma) chain (null) mice. Reviewed International journal

Ishikawa F, Yasukawa M, Lyons B, Yoshida S, Miyamoto T, Yoshimoto G, Watanabe T, Akashi K, Shultz LD, Harada M:

Blood   106 ( 5 )   1565 - 1573   2005.5

Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype. Reviewed International journal

Growney JD, Shigematsu H, Li Z, Lee BH, Adelsperger J, Rowan R, Curley DP, Kutok JL, Akashi K, Williams IR, Speck NA, Gilliland DG:

Blood   2005.3

Prognostic, therapeutic,and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations. Reviewed International journal

Mohi MG, Williams IR, Dearolf CR, Chan G, Kutok JL, Cohen S, Morgan K, Boulton C, Shigematsu H, Keilhack H, Akashi K, Gilliland DG, Neel BG:

Cancer Cell   2005.2

Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells. Reviewed International journal

Opferman JT, Iwasaki H, Ong CC, Suh H, Akashi K, and Korsmeyer S.

Science   2005.1

Identification of eosinophil lineage-committed progenitors in the murine bone marrow. Reviewed International journal

Iwasaki H, Mizuno S, Mayfield R, Shigematsu H, Arinobu Y, Seed B, Gurish MF, Takatsu K,and Akashi K.

Journal of Experimental Medicine   201 ( 12 )   1891 - 1897   2005.1

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor,PU.1. Reviewed International journal

Rosenbauer F,Wagner K,Kutok JL,Iwasaki H,Le Beau MM,Okuno Y,Akashi K,Fiering S,Tenen DJ.

Nature Genetics   2004.1

Moz-TIF2 but not BCR-ABL confers properties of leukaemic stem cells to committed murine hematopoietic progenitors. Reviewed International journal

Huntly BJP,Shigematsu H,Deguchi K,Lee BH,Mizuno S,Duclos N,Rowan R,Amaral S,Curley D,Williams IR,Akashi K,and Gilliland DG.

Cancer Cell   2004.1

Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development. Reviewed International journal

Yan M,Burel SA,Peterson LF,Kanabe E,Iwasaki H,Boyapati A,Hines R,Akashi K,and Zhang DE.

Proc.Natl.Acad.Sci.USA   2004.1

Mouse development and cell proliferation in the absence of D-cyclins. Reviewed International journal

Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, Sicinska E, Geng Y, Yu Q, Bhattacharya S, Bronson RT, Akashi K and Sicinski P

Cell   2004.1

Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin. Reviewed International journal

Shigematsu H, Reizis B, Iwasaki H, Mizuno S, Hu D, Traver D, Leder P, Sakaguchi N and Akashi K.

Immunity   21 ( 1 )   43 - 53   2004.1

Transcriptionalaccessibility for multilineage programs in hematopoietic stem and progenitor cells. Reviewed International journal

Akashi K, He X, Chen J, Iwasaki H, Niu C, Steenhard B, Zhang J, Haug J, and Li L.

Blood   2003.1

GATA-1 converts lymphoid and myelomonocytic progenitors into the megakaryocyte/erythrocyte lineages. Invited Reviewed International journal

Iwasaki H, Mizuno S, Wells RA, Watanabe S, and Akashi K.

Immunity   2003.1

Enforced GM-CSF signals in lymphoid-committed progenitors do not support lymphoid development, but instruct lymphoid to myelomonocytic lineage conversion. Reviewed International journal

Iwasaki-Arai J, Iwasaki H, Miyamoto T, Watanabe S, and Akashi K.

Journal of Experimental Medicine   197 ( 10 )   1311 - 1322   2003.1

Hematopoietic stem cells expressing the myeloid lysozyme gene retain long-term,multilineage repopulation potential. Reviewed International journal

Ye M,Iwasaki H,Laiosa CV,Stadtfeld M,Heck S,Clausen B,Akashi K and Graf T.

Immunity   2003.1

Expression of BCR/ABL and BCL-2 in myeloid progenitors leads to myeloid leukemias. Reviewed International journal

Jaiswal S,Traver D,Miyamoto T,Akashi K,Lagasse E,and Weissman IL.

Proc.Natl.Acad.Sci.USA   2003.1

Differential regulation of the human and murine CD34 genes in hematopoietic stem cells. Reviewed International journal

Okuno Y, Iwasaki H, Huettner CS, Radomska HS, Gonzalez DA, Tenen DG, and Akashi K.

Proc Natl Acad Sci USA   2002.1

Prospective isolation of human clonogenic common myeloid progenitors. Reviewed International journal

Manz M, Miyamoto T, Akashi K and Weissman IL.

Proc. Natl. Acad. Sci. USA   2002.1

Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment. Reviewed International journal

Miyamoto T, Iwasaki H, Reides B, Ye M, Graf T, Weissman IL and Akashi K.

Developmental Cell   2002.1

Myeloerythroid-restricted progenitors can alone provide radioprotection and the majority of day 8 CFU-S. Reviewed International journal

Nakorn TN, Traver D, Weissman IL and Akashi K.

Journal of Clinical Investigation   2002.1

Dendritic Cell potentials in early from lymphoid and myeloid hematopoiesis. Reviewed International journal

Manz M,Traver D,Miyamoto T,Weissman IL,and Akashi K.

Blood   2001.1

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations. Reviewed International journal

Yuan Y,Zhou L,Miyamoto T,Harakawa N,Hetherington CJ,Burel S,Lagasse E,Weissman IL,Akashi K,and Zhang DE.

Proc.Natl.Acad.Sci.USA   2001.1

The fetal liver counterpart of adult common lymphoid progenitors gives rise to all lymphoid lineages, CD45+CD4+CD3-cells,as well as macrophages. Reviewed International journal

Mebius RE,Miyamoto T,Christensen J,Domen J,Cupedo T,Weissman IL,and Akashi K.

Journal of Immunology   2001.1

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Reviewed International journal

Akashi K, Traver D, Miyamoto T, and Weissman IL.

Nature   2000.1

Development of CD8a-positive dendritic cells from a common myeloid progenitor. Reviewed International journal

Traver D, Akashi K, Manz M, Merad M, Miyamoto M, Engleman EG, and Weissman IL.

Science   2000.1

Cell fate conversion of lymphoid committed progenitors by instructive actions of cytokines. Reviewed International journal

Kondo M, Scherer DC, Miyamoto T, King AG, Akashi K, Sugamura K, and Weissman IL.

Nature   2000.1

AML1/ETO-expressing non-leukemic hematopoietic stem cells in acute myelogenous leukemia with 8;21 translocation. Reviewed International journal

Miyamoto T, Weissman IL, and Akashi K.

Proc. Natl. Acad. Sci. USA   2000.1

Two distinct pathway of positive selection for thymocytes Reviewed International journal

Akashi K, Kondo M, and Weissman IL.

Proc. Natl. Acad. Sci. USA   1998.1

Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia. Reviewed International journal

Traver D, Akashi K, Weissman IL, and Lagasse E.

Immunity   1998.1

Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Reviewed International journal

Akashi K, Kondo M, von Freeden-Jeffry U, Murray R, and Weissman IL.

Cell   1997.1

Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Reviewed International journal

Kondo M, Weissman IL, and Akashi K.

Cell   1997.1

Bcl-2 rescues T lymphopoiesis but not B or NK cell development in common cytokine receptor g chain-deficient mice. Reviewed International journal

Kondo M, Akashi K, Domen J, Sugamura K, and Weissman IL

Immunity   1997.1

The c-Kit-positive maturation pathway in mouse T cell development: lineage and selection International journal

Akashi K, and Weissman IL

Immunity   5 ( 2 )   147 - 161   1996.1

The aging of hemetopoietic stem cell Reviewed International journal

Morrison S, Waldtze A, Akashi K, Gilberson A, and Weissman IL

Nature Medicine   1996.1

Involvement of interferon-g and macrophage colony-stimulating factor in pathogenesis of hemophagocytic lymphohistiocytosis in adults. Reviewed International journal

Akashi K, Mizuno S, Harada M, Takamatsu Y, Tamura K, Shibuya T, Gondo H, Hayashi S, Okamura T, Niho Y.

British Journal of Haematology   87 ( 2 )   243 - 250   1994.1

Severe infectious mononucleosis-like syndrome and a primary human herpesvirus-6 infection in an adult. International journal

Akashi K, Eizuru Y, Sumiyoshi Y, Minematsu T, Hara S, Harada M, Niho Y, Kikuchi M, Minamishima Y.

New England Journal of Medicine   329 ( 3 )   168 - 171   1993.1

Interleukin-4 suppresses the spontaneous growth of chronic myelomonocytic leukemia cells International journal

Akashi K, Shibuya T, Harada M, Takamatsu Y, Uike N, Eto T, Niho Y.

Journal of Clinical Investigation   88 ( 1 )   223 - 230   1991.1

Analysis of Idiopathic Myelofibrosis Initiating Cell in NOD/SCID/IL2rgKO Mice. International conference

Noriyuki Saito, Fumihiko Ishikawa, Mitsuhiro Fukata,Chika Iwamoto,Moriyuki kawano,Leonard Shultz,Mine Harada, Koichi Akashi.

2008.12 

T Cell Toll-Like Receptors Play aCritical Role in Graft-Versus-Host Disease and Graft-Veresus-Leukemia International conference

2008.12 

Human SIRPA Polymorphism Modulates Macrophage-Mediated Suppression of Human Hematopoiesis. International conference

Kuriyama Takuro, Takenaka Katsuto, Kumano Takashi , Oku Seido, Urata Shingo, Nagafuji Koji, Dick John E, Danska Jayne S., Akashi Koichi

2008.12 

Protection of the Intestinal Epithelium from Conditioning with R-spondin1 Ameliorates Graft-Versus-Host Disease International conference

2008.12 

Lineage Commitment and Developmental Plasticity in Early Lymphoid Progenitors Invited International conference

Koichi Akashi

International Sosiety for Stem Cell Research 3rd Annual Meeting2005  2005.6 

Lineage instability in the early phase of lymphoid commitment Invited International conference

Koichi Akashi

2005FASEB Summer Research Conference  2005.7 

造血幹細胞と造血器癌幹細胞

赤司 浩一

第110回日本内科学会  2013.4 

治療標的としてのヒト白血病幹細胞 Invited

赤司 浩一

BIO tech 2013 国際バイオテクノロジー展  2013.5 

Epigenetic Landscape of Hematopoietic Lineage Commitment Can Be Visualized by Analysis of Incorporated H3.3 Variant International conference

koichi akashi

ISEH 42nd Annual Scientific Meeting  2013.8 

Epigenetic landscape of hematopoiesis visualized by histone H3.3 incorporation is deregulated in acute myeloid leukemia

koichi akashi

2013.10 

Cancer Stem Cells in Human Hematological Malignancies

koichi akashi

2013.10 

Visualization of the epigenetic landscape of hematopoietic lineage commitment based on the analysis of histone H3.3 incorporation

koichi akashi

2013.10 

Visualization of the epigenetic landscape of hematopoietic lineage commitment based on the analysis of histone H3.3 incorporation

koichi akashi

2013.10 

治療標的としてのヒト白血病幹細胞

赤司 浩一

第55回日本小児血液・がん学会学術集会  2013.12 

造血器癌幹細胞 　Malignant hematopoietic stem cell

赤司 浩一

第55回日本小児血液・がん学会学術集会  2013.12 

治療標的としてのヒト白血病幹細胞

赤司 浩一

「がん研究分野の特性等を踏まえた支援活動」公開シンポジウム  2014.1 

樹状細胞の分化制御機構

赤司 浩一

第21回日本樹状細胞研究会  2011.7 

Developmental biology of leukemia stem cells

koichi akashi

2011.9 

Human Cancer Stem Cells in Hematological Malignancy（ヒト造血系における癌幹細胞）

赤司 浩一

第70回日本癌学会学術総会  2011.10 

Human Cancer Stem Cells in Hematological Malignancy（ヒト造血系における癌幹細胞）

赤司 浩一

第70回日本癌学会学術総会  2011.10 

白血病幹細胞—そのコンセプトと治療への応用について

赤司 浩一

第34回日本造血細胞移植学会  2012.2 

白血病幹細胞—そのコンセプトと治療への応用について

赤司 浩一

第34回日本造血細胞移植学会  2012.2 

白血病幹細胞

赤司 浩一

第51回日本血液学会中国四国地方会  2012.3 

Role of IL-7 in T cell development from hematopoietic stem cells.

Akashi K, Kondo M, Weissman IL.

Immunological Reviews   1998.1

From stem cells to lymphocytes:biology and transplantation.

Aguila HL, Akashi K, Domen J, Gandy KL, Lagasse E, Mebius RE, Morrison SJ, Shizuru J, Strober S, Uchida N, Wright DE, Weissman IL.

Immunological Reviews   1997.1

The role of interleukin-4 in the negative regulation of leukemia cell growth.

Leukemia and Lymphoma   1993.1

日本癌学会

米国血液学会

米国免疫学会

国際実験血液学会

日本臨床腫瘍学会

ヒト骨髄性白血病における「静と動」の幹細胞維持・進展メカニズム

Grant number：16H02662  2016 - 2018

日本学術振興会  科学研究費助成事業  基盤研究(A)

骨髄ニッチを最適化した異種移植アッセイによる新規がん幹細胞アッセイ系の確立

Grant number：15K15365  2015 - 2017

科学研究費助成事業  挑戦的萌芽研究

ヒト型完全マクロファージ寛容導入免疫不全マウスによる新規がん幹細胞アッセイの確立

Grant number：24659463  2012 - 2015

科学研究費助成事業  挑戦的萌芽研究

癌幹細胞を標的とする腫瘍根絶技術の新構築の総括班

Grant number：22130001  2010 - 2014

日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

高い移植片生着効率を示すＳＩＲＰＡ変異型遺伝子導入新規ヒト化免疫不全マウスの開発

Grant number：21659239  2009 - 2011

科学研究費助成事業  挑戦的萌芽研究

幹細胞制御に関わるマイクロRNAのプロスペクティブな分離・同定法の開発

Grant number：19659249  2007 - 2008

科学研究費助成事業  萌芽研究

造血システムにおける腫瘍性幹細胞およびその悪性化に関与する遺伝子の同定

2005.4

九州大学病院 

造血システムにおける腫瘍性幹細胞およびその悪性化に関与する遺伝子の同定

Grant number：17109010  2005 - 2009

日本学術振興会  科学研究費助成事業  基盤研究(S)

胃癌および大腸癌の骨髄・末梢血・リンパ節中における転移形成能を有する遊離癌細胞(Isolated Tumor Cell, ITC)の検出とその臨床応用

Grant number：1715  2005 - 2007

科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

骨髄系およびリンパ球系に由来する樹状細胞群の純化とその細胞生物学的解析

2005 - 2006

科学研究費助成事業  特定領域研究

系統別樹状細胞前駆細胞の同定および機能解析

2005 - 2006

九州大学教育研究プログラム・研究拠点形成プロジェクト

ヒト肥満細胞前駆細胞を標的とした新しい抗アレルギー療法の開発

2004 - 2005

血液医学研究助成金

系統医学Ⅵ　アレルギー・膠原病

2019.4 - 2019.9   First semester

臨床医学群　血液

2018.10 - 2019.3   Second semester

系統医学Ⅵ　アレルギー・膠原病

2018.4 - 2018.9   First semester

臨床医学群　血液

2017.10 - 2018.3   Second semester

系統医学Ⅵ　アレルギー・膠原病

2017.4 - 2017.9   First semester

臨床医学群　血液

2016.10 - 2017.3   Second semester

系統医学Ⅵ　アレルギー・膠原病

2016.4 - 2016.9   First semester

臨床医学群　血液

2015.10 - 2016.3   Second semester

系統医学Ⅵ　アレルギー・膠原病

2015.4 - 2015.9   First semester

臨床医学群　血液

2014.10 - 2015.3   Second semester

系統医学Ⅵ　アレルギー・膠原病

2014.4 - 2014.9   First semester

医学総合講義　免疫・移植の臨床

2013.10 - 2014.3   Second semester

臨床医学群　血液

2013.10 - 2014.3   Second semester

系統医学Ⅵ　アレルギー・膠原病

2013.4 - 2013.9   First semester

医学総合講義　免疫・移植の臨床

2012.10 - 2013.3   Second semester

病態制御学-Ⅴ①②　アレルギー・膠原病・感染症概論

2012.4 - 2012.9   First semester

系統医学Ⅵ　アレルギー・膠原病

2012.4 - 2012.9   First semester

移植再生医学

2012.4 - 2012.9   First semester

病態制御学-Ⅴ①②　アレルギー・膠原病・感染症概論

2012.4 - 2012.9   First semester

臨床医学群　血液

2012.4 - 2012.9   First semester

臨床医学群　血液

2011.10 - 2012.3   Second semester

医学総合講義　免疫・移植の臨床

2011.10 - 2012.3   Second semester

系統医学Ⅵ　アレルギー・膠原病

2011.4 - 2011.9   First semester

病態制御学-Ⅴ①②　アレルギー・膠原病・感染症概論

2011.4 - 2011.9   First semester

病態制御学-Ⅴ①②　アレルギー・膠原病・感染症概論

2011.4 - 2011.9   First semester

移植再生医学

2011.4 - 2011.9   First semester

医学総合講義（免疫・移植の臨床）　　　造血幹細胞移植

2008.10 - 2009.3   Second semester

臨床医学群（血液）　造血の仕組み

2008.10 - 2009.3   Second semester

臨床医学群（血液）造血細胞移植療法

2008.10 - 2009.3   Second semester

移植再生医学研究法

2008.4 - 2008.9   First semester

臨床医学群（血液）　造血の仕組み

2007.10 - 2008.3   Second semester

医学総合講義（免疫・移植の臨床）　　　造血幹細胞移植

2007.10 - 2008.3   Second semester

臨床医学群（血液）造血細胞移植療法

2007.10 - 2008.3   Second semester

移植再生医学研究法

2007.4 - 2007.9   First semester

移植再生医学　（幹細胞生物学）

2006.4 - 2006.9   First semester