Updated on 2024/07/28

Information

 

写真a

 
HIRATA AKIE
 
Organization
Faculty of Medical Sciences Department of Clinical Medicine Lecturer
School of Medicine Department of Medicine(Concurrent)
Title
Lecturer
Tel
0926425881
Profile
医療リアルワールドデータを活用した臨床疫学研究の実践と教育。
External link

Degree

  • MD.

  • PhD.

Research Interests・Research Keywords

  • Research theme:Classification of patterns in long-term choice/shift of medication for hypertension using Japanese large real world data

    Keyword:real world data, pattern in time course

    Research period: 2024.4

  • Research theme:Real world evidence of the association between blood transfusion and clinical outcomes

    Keyword:real world data, electronic medical records, blood transfusion, guidelines

    Research period: 2021.8

Papers

  • No clear infuence of treatment escalation on fare prevention in serologically active clinically quiescent patients with systemic lupus erythematosus: a retrospective cohort study Reviewed International journal

    Masahiro Ayano, Akie Hirata, Shoji Tokunaga, Hiroko Furuhashi, Yasutaka Kimoto, Nobuyuki Ono, Yojiro Arinobu, Naoki Nakashima, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro

    Rheumatology International   2024.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: Rheumatology International https://doi.org/10.1007/s00296-024-05593-6

  • Association Between Reduced Posterior Occlusal Contact and Alzheimer's Disease Onset in Older Japanese Adults: Results from the LIFE Study. Reviewed International journal

    Miyano T, Ayukawa Y, Anada T, Takahashi I, Furuhashi H, Tokunaga S, Hirata A, Nakashima N, Kato K, Fukuda H.

    97 ( 2 )   871 - 881   2024.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3233/JAD-230449

  • Factors affecting patient satisfaction related to cost and treatment effectiveness in rheumatoid arthritis: results from the multicenter observational cohort study, FRANK Registry Reviewed International journal

    Toshifumi Fujiwara, Masakazu Kondo, Hisakata Yamada, Akihisa Haraguchi, Kenjiro Fujimura, Koji Sakuraba, Satoshi Kamura, Jun-Ichi Fukushi, Hisaaki Miyahara, Yasushi Inoue, Tomomi Tsuru, Toshihide Shuto, Seiji Yoshizawa, Eiichi Suematsu, Tomoya Miyamura, Masahiro Ayano, Hiroki Mitoma, Yojiro Arinobu, Hiroaki Niiro, Masanobu Ohishi

    Arthritis Research and Therapy   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1186/s13075-022-02746-5

  • Increased risk of metastasis in patients with incidental use of renin-angiotensin system inhibitors: a retrospective analysis for multiple types of cancer based on electronic medical records Reviewed International journal

    Akie Hirata, Shin Ishikane, Fumi Takahashi, masaki arioka, Tasuku Okui, Chinatsu Nojiri, Toshiyuki Sasaguri, Naoki Nakashima

    Hypertension Research   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1038/s41440-022-01038-4

  • Serum immunoglobulin G as a discriminator of infection in follicular lymphoma patients undergoing chemotherapy with bendamustine in combination with rituximab Reviewed International journal

    Akie Hirata, Kaname Miyashita, Takafumi Tanaka, Kiyoko Hirata, Taisuke Narazaki, Hayato Utsunomiya, Hirofumi Ohno, Eriko Nakashima, Yoshimichi Tachikawa, Ilseung Choi, Kenichi Taguchi, Youko Suehiro

    Hematology   27 ( 1 )   384   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1080/16078454.2022.2051863

  • Rapid decrease in eGFR with concomitant use of tyrosine kinase inhibitors and renin–aldosterone–angiotensin system inhibitors in patients with chronic myelogenous leukemia Reviewed International journal

    2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of chronic myeloid leukemia (CML). However, TKI-related chronic renal toxicity has been reported, particularly in patients with hypertension. We assessed whether incidental use of specific types of antihypertensive drugs, including renin–aldosterone–angiotensin system inhibitors (RAASis), affects the change in estimated glomerular filtration rate (eGFR) during TKI treatment. We retrospectively analyzed all eGFR measurements during TKI treatment for 142 CML patients at Kyushu University Hospital, estimating the rate of eGFR change using a mixed-effects model. Overall, a significant interaction was found between the type of antihypertensive medication used and the yearly change in eGFR (P < 0.01), with RAASi users exhibiting the most rapid decrease in eGFR (− 5.5%/year). The analysis by TKI used showed that the interaction was significant only in imatinib and bosutinib users (P < 0.01 and P = 0.04, respectively). The yearly rate of eGFR decrease was the most notable in RAASi users, at − 5.7 (− 6.6, − 4.9) and − 10.1 (− 12.3, − 7.9) for imatinib and bosutinib users, respectively. Our findings indicate that eGFR should be carefully monitored in patients taking these TKIs.

    DOI: https://doi.org/10.1007/s12185-022-03433-6

  • Association of Esophageal Cancer Mortality with Municipal Socioeconomic Deprivation Level in Japan, 2013–2017: An Ecological Study Using Nationwide Data Reviewed International journal

    2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    This study aimed to show geographical differences in esophageal cancer mortality in Japan and reveal an association of esophageal cancer mortality with municipal socioeconomic deprivation level. Esophageal cancer mortality data in the Vital Statistics from 2013 to 2017 for each municipality and corresponding population data were analyzed. The deprivation level was derived from the municipal socioeconomic variables by principal component analysis. Municipalities were classified into five quintiles based on the deprivation level, and an association between the level and esophageal cancer mortality was evaluated using a Bayesian spatial model. As a result of regression analysis, the relative risk of esophageal cancer mortality tended to become larger as the deprivation level increased irrespective of sex, and the relative risk of esophageal cancer mortality was significantly higher in quintile 5 (most deprived) than quintile 1 (least deprived) among men and women. These results suggest that the deprivation level increases the risk of esophageal cancer mortality in Japan.

    DOI: https://doi.org/10.3390/ijerph19095483

  • Efficacy and Safety of the Modified EPOCH Regimen (Etoposide, Vincristine, Doxorubicin, Carboplatin, and Prednisolone) for Adult T-cell Leukemia/Lymphoma A Multicenter Retrospective Study Reviewed

    Yasuhiro Tsukamoto, Junichi Kiyasu, Ilseung Choi, Mitsuo Kozuru, Naokuni Uike, Hayato Utsunomiya, Akie Hirata, Eriko Fujioka, Hirofumi Ohno, Eriko Nakashima, Yasuhiro Nakashima, Kaname Miyashita, Yoshimichi Tachikawa, Taisuke Narazaki, Mariko Tsuda, Shojiro Haji, Akiko Takamatsu, Emi Tanaka, Tatsuro Goto, Hiroshi Takatsuki, Makoto Oyama, Hiroki Muta, Yu Yagi, Motohiko Ikeda, Takamitsu Matsushima, Yuji Yufu, Youko Suehiro

    Clinical Lymphoma, Myeloma and Leukemia   20 ( 7 )   e445 - e453   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.clml.2020.03.008

  • Genomewide association study of leisure-time exercise behavior in Japanese Adults Reviewed

    Megumi Hara, Tsuyoshi Hachiya, Yoichi Sutoh, Keitaro Matsuo, Yuichiro Nishida, Chisato Shimanoe, Keitaro Tanaka, Atsushi Shimizu, Keizo Ohnaka, Takahisa Kawaguchi, Isao Oze, Fumihiko Matsuda, Hidemi Ito, Sayo Kawai, Asahi Hishida, Rieko Okada, Tae Sasakabe, Akie Hirata, Rie Ibusuki, Yora Nindita, Norihiro Furusyo, Hiroaki Ikezaki, Nagato Kuriyama, Etsuko Ozaki, Haruo Mikami, Yohko Nakamura, Sadao Suzuki, Akihiro Hosono, Sakurako Katsuura-Kamano, Kokichi Arisawa, Kiyonori Kuriki, Kaori Endoh, Naoyuki Takashima, Aya Kadota, Masahiro Nakatochi, Yukihide Momozawa, Michiaki Kubo, Mariko Naito, Kenji Wakai

    Medicine and science in sports and exercise   50 ( 12 )   2433 - 2441   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1249/MSS.0000000000001712

  • Latent psychological distress existing behind a set of assessment measures is comparable to or more important than symptoms or disability in the association with quality of life and working status of patients with rheumatoid arthritis Reviewed

    Akie Hirata, Tomoya Miyamura, Yasuo Suenaga, Masao Katayama, Eiichi Suematsu, Shigeto Tohma

    Modern Rheumatology   28 ( 6 )   968 - 975   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/14397595.2018.1428043

  • Modification of the associations of alcohol intake with serum low-density lipoprotein cholesterol and triglyceriwdes by ALDH2 and ADH1B polymorphisms in Japanese men Reviewed

    Tae Sasakabe, Kenji Wakai, Sayo Kawai, Asahi Hishida, Mariko Naito, Sadao Suzuki, Yora Nindita, Kokichi Arisawa, Yoshikuni Kita, Megumi Hara, Nagato Kuriyama, Akie Hirata, Haruo Mikami, Isao Oze, Michiaki Kubo, Hideo Tanaka, Nobuyuki Hamajima

    Journal of epidemiology   28 ( 4 )   185 - 193   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2188/jea.JE20160189

  • Effect of early treatment on physical function in daily management of rheumatoid arthritis A 5-year longitudinal study of rheumatoid arthritis patients in the national database of rheumatic diseases in Japan Reviewed

    Akie Hirata, Yasuo Suenaga, Tomoya Miyamura, Toshihiro Matsui, Shigeto Tohma, Eiichi Suematsu, Keizo Ohnaka, Ryoichi Takayanagi

    International Journal of Rheumatic Diseases   21 ( 4 )   828 - 835   2018

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1756-185X.12877

  • Effect modification of green tea on the association between rice intake and the risk of diabetes mellitus A prospective study in Japanese men and women Reviewed

    Akie Hirata, Keizo Ohnaka, Naotaka Tashiro, Zhenjie Wang, Michiko Kohno, Chikako Kiyohara, Suminori Kono, Ryoichi Takayanagi

    Asia Pacific Journal of Clinical Nutrition   26 ( 3 )   545 - 555   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.6133/apjcn.042016.04

  • High-sensitivity C-reactive protein and risks of all-cause and cause-specific mortality in a Japanese population Reviewed

    Hoirun Nisa, Akie Hirata, Michiko Kohno, Chikako Kiyohara, Keizo Ohnaka

    Asian Pacific Journal of Cancer Prevention   17 ( 5 )   2643 - 2648   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.7314/APJCP.2016.17.5.2643

  • Influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the Japanese general population Reviewed

    , Yuichiro Nishida, Megumi Hara, Tatsuhiko Sakamoto, Koichi Shinchi, Sayo Kawai, Mariko Naito, Nobuyuki Hamajima, Aya Kadota, Sadao Suzuki, Rie Ibusuki, Akie Hirata, Miwa Yamaguchi, Nagato Kuriyama, Isao Oze, Haruo Mikami, Michiaki Kubo, Hideo Tanaka

    Preventive Medicine Reports   3   288 - 295   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.pmedr.2016.03.010

  • Genetic variants of SLC17A1 are associated with cholesterol homeostasis and hyperhomocysteinaemia in Japanese men Reviewed

    Teruhide Koyama, Daisuke Matsui, Nagato Kuriyama, Etsuko Ozaki, Keitaro Tanaka, Isao Oze, Nobuyuki Hamajima, Kenji Wakai, Rieko Okada, Kokichi Arisawa, Haruo Mikami, Keiichi Shimatani, Akie Hirata, Naoyuki Takashima, Sadao Suzuki, Chisato Nagata, Michiaki Kubo, Hideo Tanaka

    Scientific reports   5   2015.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep15888

  • Expression of programmed cell death ligand 1 is associated with poor overall survival in patients with diffuse large B-cell lymphoma Reviewed

    Junichi Kiyasu, Hiroaki Miyoshi, Akie Hirata, Fumiko Arakawa, Ayako Ichikawa, Daisuke Niino, Yasuo Sugita, Yuji Yufu, Ilseung Choi, Yasunobu Abe, Naokuni Uike, Koji Nagafuji, Takashi Okamura, Koichi Akashi, Ryoichi Takayanagi, Motoaki Shiratsuchi, Koichi Ohshima

    Blood   126 ( 19 )   2193 - 2201   2015.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2015-02-629600

  • Behavioral and clinical correlates of serum bilirubin concentrations in Japanese men and women Reviewed

    Maya Tanaka, Sanjeev Budhathoki, Akie Hirata, Makiko Morita, Suminori Kono, Masahiro Adachi, Hisaya Kawate, Keizo Ohnaka, Ryoichi Takayanagi

    BMC Endocrine Disorders   13   2013.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/1472-6823-13-39

  • Behavioral and clinical correlates of high-sensitivity C-reactive protein in Japanese men and women Reviewed

    Akie Hirata, Keizo Ohnaka, Makiko Morita, Kengo Toyomura, Suminori Kono, Ken Yamamoto, Masahiro Adachi, Hisaya Kawate, Ryoichi Takayanagi

    Clinical Chemistry and Laboratory Medicine   50 ( 8 )   1469 - 1476   2012.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1515/cclm-2011-0839

  • A case of refractory adult-onset Still's disease with high serum interleukin-18 levels treated with monitoring of serum levels of cyclosporine. Reviewed

    Yoshiro Horai, Atsuko Koyama, Tomoya Miyamura, Akie Hirata, Masataka Nakamura, Hitoshi Ando, Soichiro Takahama, Rumi Minami, Masahiro Yamamoto, Eiichi Suematsu

    Fukuoka igaku zasshi = Hukuoka acta medica   103 ( 1 )   24 - 28   2012.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Churg-Strauss syndrome associated with elevated levels of serum interleukin-5 and T cell receptor-Cβ gene rearrangement Reviewed

    21 ( 1 )   76 - 78   2011.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    A 58-year-old woman was diagnosed with Churg-Strauss syndrome (CSS) based on the symptoms of bronchial asthma, eosinophilia, mononeuritis multiplex and histological examination of the right sural nerve. Prior to treatment, the serum interleukin (IL)-5 level was high, and rearrangement of the T cell receptor (TCR) gene was identified. This is the first report of TCR gene rearrangement in a patient with CSS. The expanded T cell clone may be responsible for the overproduction of IL-5. Further studies are warranted to disclose a prevalence of TCR gene rearrangement in CSS patients and its pathophysiological roles in the development of this disease.

    DOI: 10.1007/s10165-010-0341-3

  • Idiopathic portal hypertension in a patient with mixed connective tissue disease and protein C deficiency Reviewed

    Yoshiro Horai, Tomoya Miyamura, Akie Hirata, Masataka Nakamura, Soichiro Takahama, Hitoshi Ando, Rumi Minami, Masahiro Yamamoto, Eiichi Suematsu

    Internal Medicine   49 ( 18 )   2013 - 2016   2010.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2169/internalmedicine.49.3834

  • Churg-Strauss syndrome A retrospective study of 11 cases from a single center in Japan Reviewed

    Yoshiro Horai, Tomoya Miyamura, Akie Hirata, Masataka Nakamura, Soichiro Takahama, Hitoshi Ando, Rumi Minami, Masahiro Yamamoto, Eiichi Suematsu

    International Journal of Rheumatic Diseases   13 ( 3 )   e6 - e10   2010.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1756-185X.2010.01479.x

  • Clinical analysis of cerebrospinal fluid interleukin-6 in neuropsychiatric systemic lupus erythematosus. Reviewed

    Yoshiro Horai, Hideyuki Watanabe, Tomoya Miyamura, Soichiro Takahama, Akie Hirata, Masataka Nakamura, Hitoshi Ando, Rumi Minami, Masahiro Yamamoto, Eiichi Suematsu

    Fukuoka igaku zasshi = Hukuoka acta medica   101 ( 2 )   34 - 40   2010.2

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Refractory antineutrophil cytoplasmic antibody-associated vasculitis successfully treated with rituximab A case report Reviewed

    Yoshiro Horai, Tomoya Miyamura, Soichiro Takahama, Akie Hirata, Masataka Nakamura, Hitoshi Ando, Rumi Minami, Masahiro Yamamoto, Eiichi Suematsu

    Japanese Journal of Clinical Immunology   33 ( 2 )   105 - 110   2010

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2177/jsci.33.105

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Presentations

  • 医療情報データベースを用いた肺癌および悪性リンパ腫における実用化可能なアウトカム定義の確立

    池田 真一郎,伊豆倉 理江子,野尻 千夏,高田 敦史,平田 明恵,山下 貴範,神田橋 忠,沖 英次, 宇山 佳明,吉住 朋晴、中島 直樹

    第27回日本医療情報学会春季学術大会  2023.6 

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    Event date: 2023.6 - 2023.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:沖縄コンベンションセンター   Country:Japan  

  • 消化管癌患者の貧血に対する外科的切除手術前輸血と術後早期全身状態との関連

    平田明恵、神田橋忠 、藤沙織、池田真一郎 、野尻千夏、中島直樹

    日本臨床疫学会  2022.11 

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    Event date: 2022.11

    Language:Japanese  

    Country:Japan  

Professional Memberships

  • 日本リウマチ学会

  • 日本内科学会

  • 日本臨床疫学会

Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2023

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:1

Research Projects

  • 大規模リアルワールドデータに基づく降圧薬処方推移の時系列パターン分類

    Grant number:24K09914  2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 九州大学オープンサイエンプラットフォーム

    2021.4

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    我が国の高い技術力を高効率に市場価値に結び付けるには、従来のHow to do型のオープンイノ
    ベーションではなく、What to do型の新しい仕組みが必要です。九州大学オープンサイエンスプ
    ラットフォーム(OSP)は、この目的のために今後最大のマーケットであるヘルステック市場において、
    様々な企業の技術を価値に転換できる仕組みとしてスタートしました。
    OSPは、イノベーション創出手法として認知されているデザイン思考法を用いながら、その問題点
    であるアイデアの確実性をデジタルトランスフォーメーション(DX)により担保する初めての試み
    です。大学、理研、企業のメンバーが、学生とともに、解決課題を設定し、メディカルビッグデー
    タ(九州大学病院など)で関連する因子を探し出し、これを基に価値のアイデア創出、要素価値の
    研究をバックキャストして実施します。
    OSPへの企業の参加のメリットは、メディカルデータ解析により通常では発想できない因子(アイ
    デア)が見つかること、最終価値がそのデータで裏打ちされることで、研究の投資効率が格段に上が
    ります。また、企業単体ではリスクが大きい研究課題の最初のステージも、OSPにより大学側が学生
    の学位研究として実施することでリスクを取ることなく、成果が見えた時点で共同研究へ移行して
    獲得できます。
    OSPでは、さまざまな分野の企業が参画いただけるように、九州大学と福岡市・九州先端科学技術
    研究所で、ふくおか産学共創コンソーシアムを設立しました。九州大学病院及び関連施設のメディ
    カルビッグデータの提供、実証研究のための福岡市、糸島市との連携も確保しており、研究に伴う
    九州大学の広い分野の研究者の知見と研究設備の利用も可能となっています

Class subject

  • 医療データサイエンス概論 / Medical Data Science Basic Course

    2024.4 - 2024.9   First semester

  • 医療データサイエンス概論 / Medical Data Science Basic Course

    2023.4 - 2023.9   First semester

  • 医療データサイエンス概論 / Medical Data Science Basic Course

    2022.4 - 2022.9   First semester

  • 医療データサイエンス概論 / Medical Data Science Basic Course

    2021.4 - 2021.9   First semester

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Clinical Internal Medicine / Collagen Disease, Allergy, Infectious Disease Internal Medicine

    臨床疫学

Clinician qualification

  • Specialist

    Japan College of Rheumatology(JCR)

  • Specialist

    日本臨床疫学会

Year of medical license acquisition

  • 2006

Notable Clinical Activities

  • 診療データ活用型臨床観察研究の普及・学術的支援