Updated on 2024/06/10

Information

 

写真a

 
CHINEN TAKATOSHI
 
Organization
Faculty of Medical Sciences Department of Clinical Medicine Lecturer
Title
Lecturer
Profile
Immunology research Education of graduate students
Homepage
External link

Degree

  • Doctorate of Medicine and of Philosophy

Research Interests・Research Keywords

  • Research theme:Immunology

    Keyword:Immunology

    Research period: 2018.4 - 2030.5

Papers

  • Mucosal IL23A expression predicts the response to Ustekinumab in inflammatory bowel disease. Reviewed

    Kei Nishioka, Haruei Ogino, Takatoshi Chinen, Eikichi Ihara, Yoshimasa Tanaka, Kazuhiko Nakamura, Yoshihiro Ogawa

    Journal of gastroenterology   56 ( 11 )   976 - 987   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00535-021-01819-7

  • Mucosal Profiles of Immune Molecules Related to T Helper and Regulatory T Cells Predict Future Relapse in Patients With Quiescent Ulcerative Colitis. Reviewed International journal

    Keita Fukaura, Yoichiro Iboshi, Haruei Ogino, Eikichi Ihara, Kazuhiko Nakamura, Yuichiro Nishihara, Kei Nishioka, Takatoshi Chinen, Tsutomu Iwasa, Akira Aso, Ayako Goto, Kazuhiro Haraguchi, Hirotada Akiho, Naohiko Harada, Yoshihiro Ogawa

    Inflammatory bowel diseases   25 ( 6 )   1019 - 1027   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ibd/izy395

  • Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance. Reviewed International journal

    Clarissa Campbell, Stanislav Dikiy, Shakti K Bhattarai, Takatoshi Chinen, Fanny Matheis, Marco Calafiore, Beatrice Hoyos, Alan Hanash, Daniel Mucida, Vanni Bucci, Alexander Y Rudensky

    Immunity   48 ( 6 )   1245 - 1257   2018.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.immuni.2018.04.013

  • An essential role for the IL-2 receptor in Treg cell function. Reviewed International journal

    Takatoshi Chinen, Arun K Kannan, Andrew G Levine, Xiying Fan, Ulf Klein, Ye Zheng, Georg Gasteiger, Yongqiang Feng, Jason D Fontenot, Alexander Y Rudensky

    Nature immunology   17 ( 11 )   1322 - 1333   2016.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ni.3540

  • Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus. Reviewed International journal

    Yongqiang Feng, Aaron Arvey, Takatoshi Chinen, Joris van der Veeken, Georg Gasteiger, Alexander Y Rudensky

    Cell   158 ( 4 )   749 - 763   2014.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cell.2014.07.031

  • Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Reviewed International journal

    Steven Z Josefowicz, Rachel E Niec, Hye Young Kim, Piper Treuting, Takatoshi Chinen, Ye Zheng, Dale T Umetsu, Alexander Y Rudensky

    Nature   482 ( 7385 )   395 - 9   2012.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nature10772

  • The effects of commensal microbiota on immune cell subsets and inflammatory responses. Reviewed International journal

    Takatoshi Chinen, Alexander Y Rudensky

    Immunological reviews   245 ( 1 )   45 - 55   2012.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1600-065X.2011.01083.x

  • SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-{gamma} and IL-17A production. Reviewed International journal

    Reiko Takahashi, Shuhei Nishimoto, Go Muto, Takashi Sekiya, Taiga Tamiya, Akihiro Kimura, Rimpei Morita, Mayako Asakawa, Takatoshi Chinen, Akihiko Yoshimura

    The Journal of experimental medicine   208 ( 10 )   2055 - 67   2011.9

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    DOI: 10.1084/jem.20110428

  • Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance. Reviewed International journal

    Takatoshi Chinen, Kyoko Komai, Go Muto, Rimpei Morita, Naoko Inoue, Hideyuki Yoshida, Takashi Sekiya, Ryoko Yoshida, Kazuhiko Nakamura, Ryoichi Takayanagi, Akihiko Yoshimura

    Nature communications   2   190 - 190   2011.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ncomms1181

  • A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota. Reviewed International journal

    Takatoshi Chinen, Pavel Y Volchkov, Alexander V Chervonsky, Alexander Y Rudensky

    The Journal of experimental medicine   207 ( 11 )   2323 - 30   2010.10

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    DOI: 10.1084/jem.20101235

  • Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat. Reviewed International journal

    Kenji Ichiyama, Hideyuki Yoshida, Yu Wakabayashi, Takatoshi Chinen, Kazuko Saeki, Mako Nakaya, Giichi Takaesu, Shohei Hori, Akihiko Yoshimura, Takashi Kobayashi

    The Journal of biological chemistry   283 ( 25 )   17003 - 8   2008.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M801286200

  • Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis. Reviewed International journal

    Takehiro Torisu, Mako Nakaya, Satoko Watanabe, Masayuki Hashimoto, Hideyuki Yoshida, Takatoshi Chinen, Ryoko Yoshida, Fuyuki Okamoto, Toshikatsu Hanada, Kumiko Torisu, Giichi Takaesu, Takashi Kobayashi, Hideo Yasukawa, Akihiko Yoshimura

    Hepatology (Baltimore, Md.)   47 ( 5 )   1644 - 54   2008.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/hep.22214

  • STAT6 Inhibits TGF-beta1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor. Reviewed International journal

    Hiromi Takaki, Kenji Ichiyama, Keiko Koga, Takatoshi Chinen, Giichi Takaesu, Yuki Sugiyama, Shigeaki Kato, Akihiko Yoshimura, Takashi Kobayashi

    The Journal of biological chemistry   283 ( 22 )   14955 - 62   2008.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M801123200

  • Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells. Reviewed International journal

    Yumiko Matsumura, Takashi Kobayashi, Kenji Ichiyama, Ryoko Yoshida, Masayuki Hashimoto, Tomohito Takimoto, Kentaro Tanaka, Takatoshi Chinen, Takashi Shichita, Tony Wyss-Coray, Katsuaki Sato, Akihiko Yoshimura

    Journal of immunology (Baltimore, Md. : 1950)   179 ( 4 )   2170 - 9   2007.8

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  • Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis. Reviewed International journal

    Hisanobu Ogata, Takashi Kobayashi, Takatoshi Chinen, Hiromi Takaki, Takahito Sanada, Yasumasa Minoda, Keiko Koga, Giichi Takaesu, Yoshihiko Maehara, Mitsuo Iida, Akihiko Yoshimura

    Gastroenterology   131 ( 1 )   179 - 93   2006.7

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  • IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. Reviewed International journal

    Toshikatsu Hanada, Takashi Kobayashi, Takatoshi Chinen, Kazuko Saeki, Hiromi Takaki, Keiko Koga, Yasumasa Minoda, Takahito Sanada, Tomoko Yoshioka, Hiromitsu Mimata, Seiya Kato, Akihiko Yoshimura

    The Journal of experimental medicine   203 ( 6 )   1391 - 7   2006.6

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  • Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved. Reviewed International journal

    Takatoshi Chinen, Takashi Kobayashi, Hisanobu Ogata, Giichi Takaesu, Hiromi Takaki, Masayuki Hashimoto, Hideo Yagita, Hajime Nawata, Akihiko Yoshimura

    Gastroenterology   130 ( 2 )   373 - 88   2006.2

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  • Pedunculated cap polyps preceding the development of cap polyposis: case report. Reviewed International journal

    Takatoshi Chinen, Tadashi Misawa, Takashi Yao, Toshifumi Nasu, Koki Yoshida, Shigeru Kubo, Satoshi Toyoshima, Tsugio Sakaguchi, Naohiko Harada

    Gastrointestinal endoscopy   61 ( 2 )   338 - 40   2005.2

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  • Esophageal submucosal gland duct adenoma. Reviewed International journal

    Takatoshi Chinen, Tadashi Misawa, Koki Yoshida, Toshifumi Nasu, Shigeru Kubo, Satoshi Toyoshima, Takashi Yao, Naohiko Harada

    Gastrointestinal endoscopy   60 ( 5 )   798 - 9   2004.11

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  • Mucosal T cells bearing TCRgammadelta play a protective role in intestinal inflammation. Reviewed International journal

    Kyoko Inagaki-Ohara, Takatoshi Chinen, Goro Matsuzaki, Atsuo Sasaki, Yukiko Sakamoto, Kenji Hiromatsu, Fukumi Nakamura-Uchiyama, Yukifumi Nawa, Akihiko Yoshimura

    Journal of immunology (Baltimore, Md. : 1950)   173 ( 2 )   1390 - 8   2004.7

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  • IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Reviewed International journal

    Hideo Yasukawa, Masanobu Ohishi, Hiroyuki Mori, Masaaki Murakami, Takatoshi Chinen, Daisuke Aki, Toshikatsu Hanada, Kiyoshi Takeda, Shizuo Akira, Masahiko Hoshijima, Toshio Hirano, Kenneth R Chien, Akihiko Yoshimura

    Nature immunology   4 ( 6 )   551 - 6   2003.6

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  • Development of a new endoscopy system to visualize bilirubin for the diagnosis of duodenogastroesophageal reflux. International journal

    Masafumi Wada, Yosuke Minoda, Eikichi Ihara, Hirotaka Tsuru, Yoshitaka Hata, Shuzaburo Nagatomo, Mitsuru Esaki, Xiaopeng Bai, Yoshimasa Tanaka, Takatoshi Chinen, Haruei Ogino, Yoshihiro Ogawa

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   2023.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/den.14749

  • Evaluating the efficacy and safety of acotiamide in patients with esophagogastric junction outflow obstruction: study protocol for an investigator-initiated, multi-center, randomized, double-blind, placebo-controlled phase II trial. International journal

    Mitsuru Esaki, Eikichi Ihara, Noriaki Manabe, Noriyuki Kawami, Katsuhiko Iwakiri, Junichi Akiyama, Shiko Kuribayashi, Toshio Uraoka, Haruei Ogino, Takatoshi Chinen, Akiko Misumi, Hiroko Watanabe, Maya Suzuki, Junji Kishimoto, Yoshihiro Ogawa

    Trials   24 ( 1 )   459 - 459   2023.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13063-023-07468-w

  • Auxiliary diagnosis of subepithelial lesions by impedance measurement during endoscopic ultrasound guided fine-needle biopsy. International journal

    Yosuke Minoda, Mitsuru Esaki, Eikichi Ihara, Shuzaburo Nagatomo, Kei Nishioka, Nao Fujimori, Haruei Ogino, Xiaopeng Bai, Yoshimasa Tanaka, Takatoshi Chinen, Qingjiang Hu, Mitsuhiko Ota, Shinya Umekita, Hidetaka Yamamoto, Yoshihiro Ogawa

    Gastrointestinal endoscopy   97 ( 5 )   977 - 984   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.gie.2022.11.022

  • Efficacy of ultrasound endoscopy with artificial intelligence for the differential diagnosis of non-gastric gastrointestinal stromal tumors. International journal

    Yosuke Minoda, Eikichi Ihara, Nao Fujimori, Shuzaburo Nagatomo, Mitsuru Esaki, Yoshitaka Hata, Xiaopeng Bai, Yoshimasa Tanaka, Haruei Ogino, Takatoshi Chinen, Qingjiang Hu, Eiji Oki, Hidetaka Yamamoto, Yoshihiro Ogawa

    Scientific reports   12 ( 1 )   16640 - 16640   2022.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-022-20863-8

  • Improved esophagography screening for esophageal motility disorders using wave appearance and supra-junctional ballooning.

    Yoshitaka Hata, Eikichi Ihara, Masafumi Wada, Hirotaka Tsuru, Kazumasa Muta, Yosuke Minoda, Xiaopeng Bai, Mitsuru Esaki, Yoshimasa Tanaka, Takatoshi Chinen, Haruei Ogino, Ryuichi Sakamoto, Yoshihiro Ogawa

    Journal of gastroenterology   57 ( 11 )   838 - 847   2022.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00535-022-01913-4

  • Determination of Region-Specific Roles of the M3 Muscarinic Acetylcholine Receptor in Gastrointestinal Motility. International journal

    Yoko Igarashi-Hisayoshi, Eikichi Ihara, Xiaopeng Bai, Chika Higashi, Hiroko Ikeda, Yoshimasa Tanaka, Mayumi Hirano, Haruei Ogino, Takatoshi Chinen, Yasushi Taguchi, Yoshihiro Ogawa

    Digestive diseases and sciences   68 ( 2 )   439 - 450   2022.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10620-022-07637-y

  • Involvement of interstitial cells of Cajal in nicotinic acetylcholine receptor-induced relaxation of the porcine lower esophageal sphincter. International journal

    Yoshihiro Otsuka, Xiaopeng Bai, Yoshimasa Tanaka, Eikichi Ihara, Takatoshi Chinen, Haruei Ogino, Yoshihiro Ogawa

    European journal of pharmacology   910   174491 - 174491   2021.11

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    DOI: 10.1016/j.ejphar.2021.174491

  • The treatment effects of acotiamide in esophagogastric outflow obstruction: a prospective longitudinal observational study.

    Eikichi Ihara, Haruei Ogino, Kazumasa Muta, Shohei Hamada, Masafumi Wada, Yoshitaka Hata, Hiroko Ikeda, Xiaopeng Bai, Yosuke Minoda, Mitsuru Esaki, Yoshimasa Tanaka, Takatoshi Chinen, Yoshihiro Ogawa

    Esophagus : official journal of the Japan Esophageal Society   19 ( 2 )   332 - 342   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10388-021-00887-1

  • Mucosa-associated gut microbiota reflects clinical course of ulcerative colitis. International journal

    Yuichiro Nishihara, Haruei Ogino, Masaru Tanaka, Eikichi Ihara, Keita Fukaura, Kei Nishioka, Takatoshi Chinen, Yoshimasa Tanaka, Jiro Nakayama, Dongchon Kang, Yoshihiro Ogawa

    Scientific reports   11 ( 1 )   13743 - 13743   2021.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-92870-0

  • Onigiri esophagography as a screening test for esophageal motility disorders. International journal

    Shohei Hamada, Eikichi Ihara, Kazumasa Muta, Masafumi Wada, Yoshitaka Hata, Hiroko Ikeda, Yoshimasa Tanaka, Haruei Ogino, Takatoshi Chinen, Yoshihiro Ogawa

    Journal of neurogastroenterology and motility   28 ( 1 )   43 - 52   2021.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5056/jnm20138

  • Role of the IL-23-T-bet/GATA3 Axis for the Pathogenesis of Ulcerative Colitis

    Haruei Ogino, Keita Fukaura, Yoichiro Iboshi, Yousuke Nagamatsu, Hiroaki Okuno, Kei Nishioka, Yuichiro Nishihara, Yoshimasa Tanaka, Takatoshi Chinen, Eikich Ihara, Yoshihiro Ogawa

    Inflammation   44 ( 2 )   592 - 603   2021.4

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10753-020-01358-y

  • Discriminant equation using mucosally expressed cytokines and transcription factor for making definite diagnosis of inflammatory bowel disease unclassified. International journal

    Hiroaki Okuno, Haruei Ogino, Eikichi Ihara, Kei Nishioka, Yoshimasa Tanaka, Takatoshi Chinen, Motoyuki Kohjima, Takamasa Oono, Masatake Tanaka, Takeshi Goya, Nao Fujimori, Yoichiro Iboshi, Takuji Gotoda, Yoshihiro Ogawa

    BMC gastroenterology   21 ( 1 )   73 - 73   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12876-021-01656-1

  • 炎症性サイトカインを用いた分類不能型炎症性腸疾患の診断予測モデルの構築

    奥野 宏晃, 荻野 治栄, 西岡 慧, 知念 孝敏, 伊原 栄吉, 小川 佳宏

    日本内科学会雑誌   110 ( Suppl. )   140 - 140   2021.2

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    Language:Japanese  

  • Efficacy of endoscopic ultrasound with artificial intelligence for the diagnosis of gastrointestinal stromal tumors

    Yosuke Minoda, Eikichi Ihara, Keishi Komori, Haruei Ogino, Yoshihiro Otsuka, Takatoshi Chinen, Yasuo Tsuda, Koji Ando, Hidetaka Yamamoto, Yoshihiro Ogawa

    Journal of Gastroenterology   55 ( 12 )   1119 - 1126   2020.12

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    DOI: 10.1007/s00535-020-01725-4

  • 【これだけは知っておきたい消化管疾患の診断・治療】消化管における慢性炎症

    荻野 治栄, 田中 義将, 知念 孝敏, 小森 圭司, 伊原 栄吉, 小川 佳宏

    消化器クリニカルアップデート   2 ( 1 )   24 - 28   2020.8

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    消化管は断続的な食物の流入と1,000種に及ぶ腸内微生物叢の存在という独特の環境下で機能する臓器である。このような過酷な環境下でいかにして健康が維持され、何がその破綻を引き起こすのか、いまだ明らかになっていないことも多い。消化管における慢性炎症の持続は、炎症性腸疾患(Inflammatory bowel disease:IBD)のみならず、過敏性腸症候群(Irritable bowel disease:IBS)をはじめとする機能性疾患の病態にも関与することが示唆されている。本稿では、炎症、免疫の観点から、消化管疾患、とくにIBD・IBS研究の要点を見直し、最新の知見やその解釈の注意点も含め考察する。(著者抄録)

  • IBD special situationにおける諸問題 肝胆膵領域の疾患を合併した潰瘍性大腸炎の臨床的特徴の検討

    荻野 治栄, 丸山 薫, 竹島 翼, 水流 大尭, 長友 周三郎, 林 康代, 永松 諒介, 奥野 宏晃, 西岡 慧, 西原 佑一郎, 大塚 宜寛, 藤森 尚, 田中 正剛, 知念 孝敏, 伊原 栄吉

    日本消化器病学会九州支部例会プログラム・抄録集   115回   77 - 77   2020.6

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  • Interleukin-1β as a Predictor of Glucocorticoid Response in Ulcerative Colitis. Reviewed International journal

    1 - 11   2020.5

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    BACKGROUND/AIM: Currently, there are no established biomarkers to differentiate between glucocorticoid (GC)-resistant and GC-sensitive ulcerative colitis (UC); however, interleukin (IL)-1β could be one such candidate biomarker. The aim of this study was to investigate whether mucosally expressed IL-1β could predict the response to GC in patients with UC. METHODS: A total of 27 mucosal tissue samples from 10 patients with GC-resistant UC (GC-resistant group), 9 patients with GC-sensitive UC (GC-sensitive group), and 8 control patients (control group) were analyzed by qRT-PCR for the expression of IL-1β, GC receptor α (GRα), GRβ, and other inflammatory mediators. Rachmilewitz endoscopic index (REI) between the GC-resistant and GC-sensitive groups was matched to avoid any potential influence of inflammation. RESULTS: The REI did not significantly differ between the GC-resistant and GC-sensitive groups. Mucosally expressed IL-1β levels in the GC-resistant group were significantly higher than those in the GC-sensitive group. However, there were no significant differences in the expression levels of GRα, GRβ, and other inflammatory mediators between the 2 groups. We could distinguish between the GC-resistant and GC-sensitive groups with a sensitivity of 90.0% and specificity of 77.8% based on mucosally expressed IL-1β. CONCLUSIONS: Mucosally expressed IL-1β can be used as a predictor of GC response in patients with UC.

    DOI: 10.1159/000507435

  • The Efficacy and Safety of a Promising Single-Channel Endoscopic Closure Technique for Endoscopic Treatment-Related Artificial Ulcers: A Pilot Study. Reviewed International journal

    Yosuke Minoda, Eikichi Ihara, Haruei Ogino, Keishi Komori, Yoshihiro Otsuka, Hiroko Ikeda, Mitsuru Esaki, Takatoshi Chinen, Takahiro Matsuguchi, Shunsuke Takahashi, Noriko Shiga, Rie Yoshimura, Yoshihiro Ogawa

    Gastrointestinal tumors   7 ( 1-2 )   21 - 29   2020.4

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    DOI: 10.1159/000503994

  • 高齢者の嚥下機能に影響を及ぼす臨床学的因子の探索 食道運動機能の観点から

    伊原 栄吉, 小川 佳宏, 荻野 治栄, 知念 孝敏

    大和証券ヘルス財団研究業績集   ( 43 )   109 - 114   2020.3

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    高解像度食道内圧検査(HRM)の検査結果に基づいた各種パラメータを用いて、加齢と性差が食道運動機能に及ぼす影響について検討した。2013年4月から2019年9月までHRM検査を施行した471名について、後方視的にHRM所見と診療情報を調査した。223例を正常群として、加齢と性差が食道運動機能に及ぼす影響について、Basal UES(上部食道括約筋) pressure、Distal contractile integral(DCI)、Basal LES(下部食道括約筋) pressureおよびIntegrated relaxation pressure(IRP)を用いて検討を行った。加齢は横紋筋領域のBasal UES pressureと相関を認めなかったが、平滑筋領域のBasal LES pressureとDCIとに負の相関を認めた。また、加齢とIRPには相関を認めなかった。一方、性差に注目した解析では、女性は男性と比較して平滑筋領域のbasal LES pressureおよびIRPが有意に高値であった。次に、性別を分けて加齢が食道運動機能に及ぼす影響についてサブ解析を行った。その結果、女性では、加齢とBasal LES pressureとの間に有意な負の相関を認め、DCIとは負の相関を認める傾向にあった。一方、加齢とBasal UES pressureおよびIRPとは相関を認めなかった。一方、男性では、加齢とDCIに有意な相関を認めたが、その他のBasal EUS pressure、Basal LES pressureおよびIRPとは有意な相関は認めなかった。最後に、これまでの正常群を用いた解析では、加齢と嚥下機能に直接的に関連するBasal UES pressureに相関が認められなかったので、食道運動異常症の群を含めて追加解析を行った。その結果、無蠕動(n=71)では、加齢とBasal UES pressureとに有意な負の相関を認めることが明らかとなった。

  • IL-1βは潰瘍性大腸炎におけるステロイド抵抗性の予測因子となる

    奥野 宏晃, 荻野 治栄, 西岡 慧, 知念 孝敏, 伊原 栄吉, 後藤田 卓志, 小川 佳宏

    日本内科学会雑誌   109 ( Suppl. )   232 - 232   2020.2

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  • Superiority of mucosal incision-assisted biopsy over ultrasound-guided fine needle aspiration biopsy in diagnosing small gastric subepithelial lesions: a propensity score matching analysis. Reviewed International journal

    Yosuke Minoda, Takatoshi Chinen, Takashi Osoegawa, Soichi Itaba, Kazuhiro Haraguchi, Hirotada Akiho, Akira Aso, Yorinobu Sumida, Keishi Komori, Haruei Ogino, Eikichi Ihara, Yoshihiro Ogawa

    BMC gastroenterology   20 ( 1 )   19 - 19   2020.1

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    DOI: 10.1186/s12876-020-1170-2

  • 食物抗原除去療法が有用であった好酸球性胃腸炎の1例

    丸山 薫, 長友 周三郎, 荻野 治栄, 中村 典資, 竹島 翼, 水流 大尭, 和田 将史, 小森 圭司, 畑 佳孝, 知念 孝敏, 伊原 栄吉, 壁村 哲平, 小川 佳宏

    日本消化器病学会九州支部例会プログラム・抄録集   114回   131 - 131   2019.11

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  • Clinical Characterization of Vonoprazan-Refractory Gastroesophageal Reflux Disease. Reviewed International journal

    Shohei Hamada, Eikichi Ihara, Hiroko Ikeda, Kazumasa Muta, Haruei Ogino, Takatoshi Chinen, Yoshimasa Tanaka, Yoshihiro Ogawa

    Digestion   102 ( 2 )   1 - 8   2019.10

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    DOI: 10.1159/000503340

  • Objective validity of the Japan Narrow-Band Imaging Expert Team classification system for the differential diagnosis of colorectal polyps. Reviewed International journal

    Yosuke Minoda, Haruei Ogino, Takatoshi Chinen, Eikichi Ihara, Kazuhiro Haraguchi, Hirotada Akiho, Nobuyoshi Takizawa, Akira Aso, Yosuke Tomita, Mitsuru Esaki, Keishi Komori, Yoshihiro Otsuka, Tsutomu Iwasa, Yoshihiro Ogawa

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   31 ( 5 )   544 - 551   2019.9

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    DOI: 10.1111/den.13393

  • Involvement of different receptor subtypes in prostaglandin E2-induced contraction and relaxation in the lower esophageal sphincter and esophageal body. Reviewed International journal

    Xiaopeng Bai, Eikichi Ihara, Yoshihihro Otsuka, Shinichi Tsuruta, Katsuya Hirano, Yoshimasa Tanaka, Haruei Ogino, Mayumi Hirano, Takatoshi Chinen, Hirotada Akiho, Kazuhiko Nakamura, Yoshinao Oda, Yoshihiro Ogawa

    European journal of pharmacology   857   172405 - 172405   2019.8

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    DOI: 10.1016/j.ejphar.2019.172405

  • 当院におけるPPI抵抗性GERDに対するボノプラザン投与症例の検討

    濱田 匠平, 牟田 和正, 向井 康二, 畑 佳孝, 池田 浩子, 小森 圭司, 岩佐 勉, 荻野 治栄, 知念 孝敏, 伊原 栄吉

    日本消化管学会雑誌   3 ( Suppl. )   241 - 241   2019.2

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  • 内視鏡的粘膜下層剥離術を施行した下咽頭脂肪肉腫の一例

    永松 諒介, 荻野 治栄, 林 康代, 和田 将史, 大塚 宣寛, 小森 圭司, 畑 佳孝, 岩佐 勉, 知念 孝敏, 伊原 栄吉, 小川 佳宏, 若崎 高裕, 山元 英崇, 野崎 優衣, 次郎丸 梨那, 小田 義直

    日本消化器病学会九州支部例会プログラム・抄録集   112回   115 - 115   2018.11

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  • 炎症性腸疾患のトータルマネージメント 現状のクローン病治療から考える今後の課題

    荻野 治栄, 永松 諒介, 西岡 慧, 西原 佑一郎, 知念 孝敏, 伊原 栄吉, 小川 佳宏, 宮原 翔仁, 赤星 和也, 向坂 誠一郎, 秋穂 裕唯, 井星 陽一郎, 原田 直彦, 吉村 大輔, 落合 利彰, 松口 崇央, 中村 和彦

    日本消化器病学会九州支部例会プログラム・抄録集   112回   89 - 89   2018.11

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  • Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance. Reviewed International journal

    Campbell C, Dikiy S, Bhattarai SK, Chinen T, Matheis F, Calafiore M, Hoyos B, Hanash A, Mucida D, Bucci V, Rudensky AY.

    Immunity   2018.6

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  • An Essential Role for the IL-2 Receptor in T reg Cell Function Reviewed International journal

    Chinen T, Kannan AK, Levine AG, Fan X, Klein U, Zheng Y, Gasteiger G, Feng Y, Fontenot JD, Rudensky AY.

    Nature immunology   2016.11

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  • Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus. Reviewed International journal

    Feng Y, Arvey A, Chinen T, van der Veeken J, Gasteiger G, Rudensky AY.

    Cell   2014.8

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  • Extrathymically generated regulatory T cells control mucosal Th2 inflammation. Reviewed International journal

    Josefowicz S, Niec R, Kim HY, Treuting P, Chinen T, Umetsu DT, Rudensky AY.

    Nature   2012.2

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  • Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance. Reviewed International journal

    Chinen T, Komai K, Muto G, Morita R, Inoue N, Yoshida H, Sekiya T, Nakamura K, Yoshimura A.

    Nature Communications   2011.2

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  • A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota. Reviewed International journal

    Chinen T, Volchkov PY, Chervonsky AV, Rudensky AY.

    The Journal of Experimental Medicine   2010.10

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  • Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice. Reviewed International journal

    Jiro Horino, Minoru Fujimoto, Fumitaka Terabe, Satoshi Serada, Tsuyoshi Takahashi, Yoshihito Soma, Kentaro Tanaka, Takatoshi Chinen, Akihiko Yoshimura, Shintaro Nomura, Ichiro Kawase, Norio Hayashi, Tadamitsu Kishimoto, Tetsuji Naka

    International immunology   20 ( 6 )   753 - 62   2008.6

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    DOI: 10.1093/intimm/dxn033

  • Peptidoglycan and lipopolysaccharide activate PLCgamma2, leading to enhanced cytokine production in macrophages and dendritic cells. Reviewed International journal

    Daisuke Aki, Yasumasa Minoda, Hideyuki Yoshida, Satoko Watanabe, Ryoko Yoshida, Giichi Takaesu, Takatoshi Chinen, Toshiya Inaba, Masaki Hikida, Tomohiro Kurosaki, Kazuko Saeki, Akihiko Yoshimura

    Genes to cells : devoted to molecular & cellular mechanisms   13 ( 2 )   199 - 208   2008.2

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    DOI: 10.1111/j.1365-2443.2007.01159.x

  • Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-β1 production Reviewed

    25 ( 17 )   2520 - 2530   2006.4

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    DOI: 10.1038/sj.onc.1209281

  • SOCS1 regulates inflammatory bowel disease in which both IFNg and IL-4 are involved. Reviewed International journal

    Chinen T, Kobayashi T, Ogata H, Takaesu G, Takaki H, Yagita H, Nawata H, Yoshimura A.

    Gastroenterology   2006.2

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  • The role of suppressor of cytokine signaling 1 as a negative regulator for aberrant expansion of CD8alpha+ dendritic cell subset. Reviewed International journal

    Jun Tsukada, Akemi Ozaki, Toshikatsu Hanada, Takatoshi Chinen, Ryo Abe, Akihiko Yoshimura, Masato Kubo

    International immunology   17 ( 9 )   1167 - 78   2005.9

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  • SOCS3 inhibits hepatitis-induced hepatocarcinogenesis

    H Ogata, T Yoshida, T Chinen, T Hirahashi, K Azuma, M Ida, A Yoshimura

    GASTROENTEROLOGY   128 ( 4 )   A685 - A685   2005.4

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  • サイトカイン抑制シグナル分子SOCS1によるCD8α樹状細胞の制御

    塚田 旬, 花田 俊勝, 知念 孝敏, 安部 良, 吉村 昭彦, 久保 允人

    日本免疫学会総会・学術集会記録   34   205 - 205   2004.11

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  • SOCS3 inhibits experimental liver fibrosis

    H Ogata, M Kamio, T Yoshida, T Chinen, T Hirahashi, M Iida, A Yoshimura

    GASTROENTEROLOGY   126 ( 4 )   A668 - A668   2004.4

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  • 炎症性腸疾患(IBD)発症における腸粘膜γδT細胞の役割

    稲垣 匡子, 知念 孝敏, 花田 俊勝, 吉村 昭彦

    日本免疫学会総会・学術集会記録   32   45 - 45   2002.10

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  • [Clinical study of individual TS-1 therapy for inoperable gastric cancer]. Reviewed

    Shigeru Kubo, Tadashi Misawa, Kohki Yoshida, Toshifumi Nasu, Yuji Ihara, Takatoshi Chinen, Naohiko Harada, Hajime Nawada

    Gan to kagaku ryoho. Cancer & chemotherapy   29 ( 7 )   1161 - 5   2002.7

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▼display all

MISC

  • 経口免疫寛容の誘導による免疫制御 Reviewed

    知念 孝敏

    医学のあゆみ   2020.10

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  • Tregによる免疫抑制メカニズム

    知念 孝敏

    医学のあゆみ   2019.3

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  • 【樹状細胞の機能制御】 樹状細胞における炎症性サイトカイン産生抑制機構

    吉村 昭彦, 日比野 沙奈, 染谷 和江, 知念 孝敏

    臨床免疫・アレルギー科   2014.2

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  • The effects of commensal microbiota on immune cell subsets and inflammatory responses.

    Chinen T, Rudensky AY.

    Immunological Reviews   2012.1

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Professional Memberships

  • The Japanese Society for Immunology

  • Japan Gastroenterological Endoscopy Society

  • The Japanese Society of Gastroenterology

  • The Japanese Society of Internal Medicine

Research Projects

  • 抗原受容体の人為的改変によって挑む難治性炎症性疾患治療

    Grant number:23H03714  2023 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

Travel Abroad

  • 2009.4 - 2018.3

    Staying countory name 1:United States   Staying institution name 1:Memorial Sloan Kettering Cancer Center

Year of medical license acquisition

  • 1998