Updated on 2024/07/28

Information

 

写真a

 
YAGI HIROSHI
 
Organization
Kyushu University Hospital Gynecology & Obstetrics Lecturer
School of Medicine Department of Medicine(Concurrent)
Title
Lecturer
External link

Degree

  • MD

Research History

  • なし

    なし

  • なし

Research Interests・Research Keywords

  • Research theme:The role of G13 signaling in the progression of gynecological cancer

    Keyword:GPCR、G13、cancer、metastasis

    Research period: 2017.4 - 2019.3

  • Research theme:The role of GPCR signaling in the progression of gynecological cancers

    Keyword:metastasis, GPCR

    Research period: 2014.4 - 2015.5

  • Research theme:The role of GPCR signaling in metastasis of gynecologic cancer

    Keyword:GPCR, cancer , metastasis

    Research period: 2012.9

Papers

  • Tumor-derived ARHGAP35 mutations enhance the Gα13-Rho signaling axis in human endometrial cancer. Reviewed International journal

    30 ( 2 )   313   2023.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41417-022-00547-1.

  • Gα13-mediated LATS1 down-regulation contributes to epithelial-mesenchymal transition in ovarian cancer Reviewed International journal

    2019.12

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    Language:English   Publishing type:Research paper (scientific journal)  

  • GEP oncogene promotes cell proliferation through YAP activation in ovarian cancer Reviewed International journal

    Yagi H, Asanoma K, Ohgami T, Ichinoe A, Sonoda K, Kato K

    ONCOGENE   35 ( 34 )   4471 - 4480   2016.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/onc.2015.505

  • A Synthetic Biology Approach Reveals a CXCR4-G(13)-RhoSignaling Axis Driving Transendothelial Migration of Metastatic Breast Cancer Cells Reviewed International journal

    Yagi H, Tan W, Dillenburg-Pilla P, Armando S, Amornphimoltham P, Simaan M, Weigert R, Molinolo AA, Bouvier M, Gutkind JS

    SCIENCE SIGNALING   4 ( 191 )   2011.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/scisignal.2002221

  • The BHLHE40‒PPM1F‒AMPK pathway regulates energy metabolism and is associated with the aggressiveness of endometrial cancer Reviewed International journal

    300 ( 3 )   105695   2024.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jbc.2024.105695

  • Clinical Significance of Tumor Immune Microenvironment in Endometrial Endometrioid Carcinoma, Grade 1 With DNA Mismatch Repair Protein Loss. Reviewed International journal

    Hachisuga K, Kawakami M, Tomonobe H, Maenohara S, Kodama K, Yagi H, Yasunaga M, Onoyama I, Asanoma K, Yahata H, Oda Y, Kato K.

    Int J Gynecol Pathol   2024.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/PGP.0000000000001020.

  • Development of novel tracers for sentinel node identification in cervical cancer. Reviewed International journal

    Kodama K, Tateishi C, Oda T, Cui L, Kuramoto K, Yahata H, Okugawa K, Maenohara S, Yagi H, Yasunaga M, Onoyama I, Asanoma K, Mori T, Katayama Y, Kato K.

    Cancer Sci   114 ( 11 )   4216   2023.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.15927.

  • Decision-making for Subsequent Therapy for Patients With Recurrent or Advanced Endometrial Cancer Based on the Platinum-free Interval. Reviewed International journal

    Kodama K, Tateishi C, Oda T, Cui L, Kuramoto K, Yahata H, Okugawa K, Maenohara S, Yagi H, Yasunaga M, Onoyama I, Asanoma K, Mori T, Katayama Y, Kato K.

    Am J Clin Oncol.   46 ( 9 )   387   2023.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/COC.0000000000001021.

  • Prognostic impact of adding bevacizumab to carboplatin and paclitaxel for recurrent, persistent, or metastatic cervical cancer. Reviewed International journal

    Yasunaga M, Yahata H, Okugawa K, Shimokawa M, Maeda Y, Hori E, Kodama K, Yagi H, Ohgami T, Onoyama I, Asanoma K, Kato K.

    Taiwan J Obstet Gynecol.   61 ( 5 )   818   2022.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.tjog.2022.06.005.

  • Long-term follow up after sentinel node biopsy alone for early-stage cervical cancer. Reviewed International journal

    Yahata H, Kodama K, Okugawa K, Hachisuga K, Yasutake N, Maenohara S, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Asanoma K, Kobayashi H, Sonoda K, Baba S, Ishigami K, Ohishi Y, Oda Y, Kato K.

    Gynecol Oncol   165 ( 1 )   149   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ygyno.2022.01.031.

  • Evaluation of Clinical Significance of Lymphovascular Space Invasion in Stage IA Endometrial Cancer. Reviewed International journal

    Okugawa K, Yahata H, Hachisuga K, Tomonobe H, Yasutake N, Kodama K, Kenjo H, Yagi H, Ohgami T, Yasunaga M, Onoyama I, Asanoma K, Hori E, Ohishi Y, Oda Y, Kato K

    Oncology   100 ( 4 )   195   2021.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000521382.

  • Prognostic impact of the subclassification of Müllerian cancer stage IV in the FIGO 2014 staging system with a focus of extra-abdominal lymph node metastases. Reviewed International journal

    26 ( 7 )   1330   2021.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10147-021-01908-w.

  • Prognostic outcomes and risk factors for recurrence after laser vaporization for cervical intraepithelial neoplasia: a single-center retrospective study. Reviewed International journal

    Kodama K, Yahata H, Okugawa K, Tomonobe H, Yasutake N, Yoshida S, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Asanoma K, Hori E, Shimokawa M, Kato K.

    Int J Clin Oncol.   26 ( 4 )   770   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10147-020-01848-x.

  • Hypersensitivity reaction to pegylated liposomal doxorubicin administration for Mullerian carcinoma in Japanese women. Reviewed International journal

    Yamaguchi S, Yahata H, Okugawa K, Kodama K, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Asanoma K, Kato K.

    J Obstet Gynaecol Res.   47 ( 4 )   1544   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.14680.

  • Identification of genes associated with endometrial cell ageing. Reviewed International journal

    Kawamura T, Tomari H, Onoyama I, Araki H, Yasunaga M, Lin C, Kawamura K, Yokota N, Yoshida S, Yagi H, Asanoma K, Sonoda K, Egashira K, Ito T, Kato K.

    Mol Hum Reprod   27 ( 2 )   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/molehr/gaaa078.

  • YBX2 and cancer testis antigen 45 contribute to stemness, chemoresistance and a high degree of malignancy in human endometrial cancer. Reviewed International journal

    Suzuki I, Yoshida S, Tabu K, Kusunoki S, Matsumura Y, Izumi H, Asanoma K, Yagi H, Onoyama I, Sonoda K, Kohno K, Taga T, Itakura A, Takeda S, Kato K.

    Sci Rep   11 ( 1 )   4220   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-83200-5.

  • Fibronectin mediates activation of stromal fibroblasts by SPARC in endometrial cancer cells Reviewed International journal

    Yoshida S, Asanoma K, Yagi H, Onoyama I, Hori E, Matsumura Y, Okugawa K, Yahata H, Kato K

    BMC Cancer   21 ( 1 )   1 - 12   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Evaluation of adjuvant chemotherapy after abdominal trachelectomy for cervical cancer: a single-institution experience. Reviewed International journal

    Okugawa K, Yahata H, Sonoda K, Kodama K, Yagi H, Ohgami T, Yasunaga M, Onoyama I, Kaneki E, Asanoma K, Kobayashi H, Kato K.

    Int J Clin Oncol.   26 ( 1 )   216   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10147-020-01778-8.

  • Downregulation of 5-hydroxymethylcytosine is associated with the progression of cervical intraepithelial neoplasia. Reviewed International journal

    Kato M, Onoyama I, Kawakami M, Yoshida S, Kawamura K, Kodama K, Hori E, Cui L, Matsumura Y, Yagi H, Asanoma K, Yahata H, Itakura A, Takeda S, Kato K.

    PLoS One   15 ( 11 )   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0241482.

  • Dual-specificity phosphatase 6 plays a critical role in the maintenance of a cancer stem-like cell phenotype in human endometrial cancer. Reviewed International journal

    Kato M, Onoyama I, Yoshida S, Cui L, Kawamura K, Kodama K, Hori E, Matsumura Y, Yagi H, Asanoma K, Yahata H, Itakura A, Takeda S, Kato K.

    Int J Cancer   147 ( 7 )   1987   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ijc.32965.

  • Is Adjuvant Therapy Necessary for Patients with Intermediate-Risk Cervical Cancer after Open Radical Hysterectomy? Reviewed International journal

    17. Yahata H, Sonoda K, Inoue S, Yasutake N, Kodama K, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Kaneki E, Okugawa K, Asanoma K, Kato K.

    Oncology.   98 ( 12 )   853   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000508569.

  • Retrospective analysis of treatment and prognosis for uterine leiomyosarcoma: 10-year experience of a single institute. Reviewed International journal

    Kodama K, Sonoda K, Kijima M, Yamaguchi S, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Kaneki E, Okugawa K, Yahata H, Ohishi Y, Oda Y, Kato K.

    Asia Pac J Clin Oncol   16 ( 2 )   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ajco.13286.

  • Survey of the desire to have children and engage in sexual activity after trachelectomy among young Japanese women with early-stage cervical cancer. Reviewed International journal

    Yahata H, Sonoda K, Okugawa K, Yagi H, Ohgami T, Yasunaga M, Onoyama I, Kaneki E, Asanoma K, Kato K.

    45 ( 11 )   2255   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/jog.14099.

  • Mutual suppression between BHLHE40/BHLHE41 and the MIR301B-MIR130B cluster is involved in epithelial-to-mesenchymal transition of endometrial cancer cells. Reviewed International journal

    Asanoma K, Hori E, Yoshida S, Yagi H, Onoyama I, Kodama K, Yasunaga M, Ohgami T, Kaneki E, Okugawa K, Yahata H, Kato K.

    Oncotarget   10 ( 45 )   4640   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18632/oncotarget.27061.

  • Amphiregulin regulates the production of human chorionic gonadotropin in trophoblasts Reviewed International journal

    Fukami T, Yoshizato T, Miyamoto S, Yagi H, Yotsumoto F, Nabeshima K, Hachisuga T, Kuroki M, Kawarabayashi T.

    84 ( 23-24 )   796   2019.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.lfs.2009.03.009.

  • Prognostic outcome and complications of sentinel lymph node navigation surgery for early-stage cervical cancer. Reviewed International journal

    Yahata H, Kobayashi H, Sonoda K, Kodama K, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Kaneki E, Okugawa K, Baba S, Isoda T, Ohishi Y, Oda Y, Kato K.

    Int J Clin Oncol   23 ( 6 )   1167   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10147-018-1327-y.

  • Fibrosis in Preeclamptic Placentas Is Associated with Stromal Fibroblasts Activated by the Transforming Growth Factor-β1 Signaling Pathway. Reviewed International journal

    188 ( 3 )   683   2018.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ajpath.2017.11.008.

  • Serum Heparin-binding Epidermal Growth Factor-like Growth Factor (HB-EGF) as a Biomarker for Primary Ovarian Cancer Reviewed International journal

    Miyata K, Yotsumoto F, Fukagawa S, Kiyoshima C, Ouk NS, Urushiyama D, Ito T, Katsuda T, Kurakazu M, Araki R, Sanui A, Miyahara D, Murata M, Shirota K, Yagi H, Takono T, Kato K, Yaegashi N, Akazawa K, Kuroki M, Yasunaga S, Miyamoto S.

    37 ( 7 )   3955   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.11779.

  • MicroRNA-135a-3p as a promising biomarker and nucleic acid therapeutic agent for ovarian cancer Reviewed International journal

    Fukagawa S, Miyata K, Yotsumoto F, Kiyoshima C, Nam SO, Anan H, Katsuda T, Miyahara D, Murata M, Yagi H, Shirota K, Yasunaga S, Kato K, Miyamoto S.

    Cancer Sci   108 ( 5 )   886   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13210.

  • FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors. Reviewed International journal

    Kitade S, Onoyama I, Kobayashi H, Yagi H, Yoshida S, Kato M, Tsunematsu R, Asanoma K, Sonoda K, Wake N, Hata K, Nakayama KI, Kato K.

    Cancer Sci   107 ( 10 )   1399   2016.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13026.

  • Regulation of the Mechanism of TWIST1 Transcription by BHLHE40 and BHLHE41 in Cancer Cells Invited Reviewed International journal

    Asanoma K, Liu G, Yamane T, Miyanari Y, Takao T, Yagi H, Ohgami T, Ichinoe A, Sonoda K, Wake N, Kato K

    MOLECULAR AND CELLULAR BIOLOGY   35 ( 24 )   4096 - 4109   2015.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/MCB.00678-15

  • Identification of the Critical Site of Calponin 1 for Suppression of Ovarian Cancer Properties. Reviewed International journal

    Yamane T, Asanoma K, Kobayashi H, Liu G, Yagi H, Ohgami T, Ichinoe A, Sonoda K, Wake N, Kato K.

    Anticancer Res   35 ( 11 )   5993   2015.11

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Retrospective Analysis of Concurrent Chemoradiation with Triweekly Cisplatin plus 5-Fluorouracil Versus Weekly Cisplatin in Cervical Cancer. Reviewed International journal

    Sonoda K, Yahata H, Ichinoe A, Okugawa K, Kaneki E, Kawano Y, Kenjo H, Ohgami T, Yagi H, Ohga S, Asai K, Nakamura K, Honda H, Kato K.

    Anticancer Res   35 ( 6 )   3447   2015.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  • SNP55, a new functional polymorphism of MDM2-P2 promoter, contributes to allele-specific expression of MDM2 in endometrial cancers Reviewed International journal

    Okamoto K, Tsunematsu R, Tahira T, Sonoda K, Asanoma K, Yagi H, Yoneda T, Hayashi K, Wake N, Kato K.

    BMC Med Genet   16 ( 67 )   2015.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12881-015-0216-8.

  • Pre-clinical study of BK-UM, a novel inhibitor of HB-EGF, for ovarian cancer therapy. Reviewed International journal

    Nam SO, Yotsumoto F, Miyata K, Suzaki Y, Yagi H, Odawara T, Manabe S, Ishikawa T, Kuroki M, Mekada E, Miyamoto S.

    Anticancer Res   34 ( 8 )   4615   2014.8

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    Language:English   Publishing type:Research paper (scientific journal)  

  • PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation. Reviewed International journal

    Mikelis CM, Palmby TR, Simaan M, Li W, Szabo R, Lyons R, Martin D, Yagi H, Fukuhara S, Chikumi H, Galisteo R, Mukouyama YS, Bugge TH, Gutkind JS.

    J Biol Chem   288 ( 17 )   12232   2013.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M112.428599.

  • Clinical significance of amphiregulin and epidermal growth factor in colostrum Invited Reviewed International journal

    Nojiri T, Yoshizato T, Fukami T, Obama H, Yagi H, Yotsumoto F, Miyamoto S

    ARCHIVES OF GYNECOLOGY AND OBSTETRICS   286 ( 3 )   643 - 647   2012.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00404-012-2365-8

  • A novel anti-human HB-EGF monoclonal antibody with multiple antitumor mechanisms against ovarian cancer cells. International journal

    Miyamoto S, Iwamoto R, Furuya A, Takahashi K, Sasaki Y, Ando H, Yotsumoto F, Yoneda T, Hamaoka M, Yagi H, Murakami T, Hori S, Shitara K, Mekada E.

    Clin Cancer Res   17(21):6733-41 ( 21 )   2011.11

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    Publishing type:Research paper (scientific journal)  

  • Identification of the Rac-GEF P-Rex1 as an Essential Mediator of ErbB Signaling in Breast Cancer Reviewed International journal

    Sosa MS, Lopez-Haber C, Yang C, Wang H, Lemmon MA, Busillo JM, Luo J, Benovic JL, Klein-Szanto A, Yagi H, Gutkind JS, Parsons RE, Kazanietz MG

    MOLECULAR CELL   40 ( 6 )   877 - 892   2010.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.molcel.2010.11.029

  • Amphiregulin regulates the activation of ERK and Akt through epidermal growth factor receptor and HER3 signals involved in the progression of pancreatic cancer. Reviewed International journal

    Yotsumoto F, Fukami T, Yagi H, Funakoshi A, Yoshizato T, Kuroki M, Miyamoto S.

    Cancer Sci   101 ( 11 )   2351   2010.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1349-7006.2010.01671.x.

  • Semaphorin 3E Initiates Antiangiogenic Signaling through Plexin D1 by Regulating Arf6 and R-Ras Reviewed International journal

    Sakurai A, Gavard J, Annas-Linhares Y, Basile JR, Amornphimoltham P, Palmby TR, Yagi H, Zhang F, Randazzo PA, Li X, Weigert R, Gutkind JS

    MOLECULAR AND CELLULAR BIOLOGY   30 ( 12 )   3086 - 3098   2010.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1128/MCB.01652-09

  • Synergistic anti-tumor effect of paclitaxel with CRM197, an inhibitor of HB-EGF, in ovarian cancer. Reviewed International journal

    Yagi H, Yotsumoto F, Sonoda K, Kuroki M, Mekada E, Miyamoto S

    Int J Cancer   124 ( 6 )   2009.3

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Heparin-binding epidermal growth factor-like growth factor promotes transcoelomic metastasis in ovarian cancer through epithelial-mesenchymal transition. Reviewed International journal

    Yagi H, Yotsumoto F, Miyamoto S

    Int J Cancer   7 ( 10 )   3441   2008.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 0.1158/1535-7163.MCT-08-0417.

  • Validation of hb-egf and amphiregulin as targets for human cancer therapy. Reviewed International journal

    Yotsumoto F, Yagi H, Suzuki SO, Oki E, Tsujioka H, Hachisuga T, Sonoda K, Kawarabayashi T, Mekada E, Miyamoto S.

    Bioche Biophys Res Commun   365 ( 3 )   555   2008.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2007.11.015.

  • Clinical significance of RCAS1 as a biomarker of ovarian cancer. Reviewed International journal

    Sonoda K, Miyamoto S, Yotsumoto F, Yagi H, Nakashima M, Watanabe T, Nakano H.

    Oncol Rep   17 ( 3 )   623   2007.5

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Clinical significance of RCAS1 as a biomarker of uterine cancer. Reviewed International journal

    Sonoda K, Miyamoto S, Hirakawa T, Yagi H, Yotsumoto F, Nakashima M, Watanabe T, Nakano H

    Gynecol Oncol   103 ( 3 )   924   2006.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ygyno.2006.05.047.

  • Invasive potency related to RCAS1 expression in uterine cervical cancer Reviewed International journal

    Sonoda K, Miyamoto S, Hirakawa T, Yagi H, Yotsumoto F, Nakashima M, Watanabe T, Nakano H

    Gynecol Oncol   99 ( 1 )   189   2005.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ygyno.2005.06.061.

  • Clinical significance of heparin-binding epidermal growth factor-like growth factor and a disintegrin and metalloprotease 17 expression in human ovarian cancer. Reviewed International journal

    Tanaka Y, Miyamoto S, Suzuki SO, Oki E, Yagi H, Sonoda K, Yamazaki A, Mizushima H, Maehara Y, Mekada E, Nakano H.

    Clin Cancer Res   11 ( 13 )   4783   2005.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/1078-0432.CCR-04-1426.

  • Association between RCAS1 expression and microenvironmental immune cell death in uterine cervical cancer. Reviewed International journal

    Sonoda K, Miyamoto S, Hirakawa T, Yagi H, Yotsumoto F, Nakashima M, Watanabe T, Nakano H

    Gynecol Oncol   97 ( 3 )   772   2005.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ygyno.2005.02.025.

  • Clinical significance of heparin-binding epidermal growth factor-like growth factor in peritoneal fluid of ovarian cancer Reviewed International journal

    Yagi H, Miyamoto S, Tanaka Y, Sonoda K, Kobayashi H, Kishikawa T, Iwamoto R, Mekada E, Nakano H.

    Br J Cancer   92 ( 9 )   1737   2005.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/sj.bjc.6602536.

  • Heparin-binding EGF-like growth factor is a promising target for ovarian cancer therapy. Reviewed International journal

    Miyamoto S, Hirata M, Yamazaki A, Kageyama T, Hasuwa H, Mizushima H, Tanaka Y, Yagi H, Sonoda K, Kai M, Kanoh H, Nakano H, Mekada E.

    Cancer Res   64 ( 16 )   5720   2004.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/0008-5472.CAN-04-0811.

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Books

  • The role of G protein-coupled receptor signaling in The role of G protein-coupled receptor signaling in gynecologic malignancy. Molecular Diagnosis and Targeting for Gynecologic Malignancy.

    Hiroshi Yagi and Kiyoko Kato( Role: Joint author)

    Springer  2021.3 

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    Responsible for pages:p57-70   Language:English  

Presentations

  • 当科がんゲノム外来の現状と課題

    八木裕史, 大神達寛, 川上穣, 蜂須賀一寿, 前之原章司, 小玉敬亮, 安永昌史, 小野山一郎, 浅野間和夫, 矢幡秀昭, 加藤聖子

    第65回日本婦人科腫瘍学会学術講演会  2023.7 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:松江   Country:Japan  

  • 三量体Gタンパクの機能解析に基づいた新たな婦人科がん治療の開発

    八木裕史

    第74回日本産科婦人科学会学術講演会  2022.8 

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    Event date: 2022.8

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • Pembrolizumab が奏効した再発子宮体癌の一例

    八木 裕史, 貴島 雅子, 安武 伸子, 小玉 敬亮, 権丈 洋徳, 大神 達寛, 安永 昌史 , 小野山 一郎, 兼城 英輔, 奥川 馨, 淺野間 和夫, 矢幡 秀昭, 加藤 聖子

    第62回日本婦人科腫瘍学会学術講演会  2021.1 

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    Event date: 2021.1 - 2021.2

    Language:Japanese  

    Venue:WEB開催   Country:Japan  

  • GEP oncogene induces epithelial–mesenchymal transition in ovarian cancer through LATS1 proteolysis

    第71回日本産科婦人科学会学術講演会  2019.4 

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    Event date: 2020.4

    Language:English  

    Venue:Nagoya   Country:Japan  

  • The role of Ga13-Rho signaling axis in the progression of human endometrial cancer

    Yagi H, Onoyama I, Asanoma K, Kodama K, Kijima M, Yasutake N, Yasunaga M, Ohgami T, Kaneki E, Okugawa K, Yahata H, Kato K

    2020.4 

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    Event date: 2020.4

    Language:Japanese  

    Country:Japan  

  • Ga13-mediated LATS1 down-regulation contributes to epithelial–mesenchymal transition in ovarian cancer

    第78回日本癌学会学術総会  2019.9 

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    Event date: 2019.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:Kyoto   Country:Japan  

  • GEP oncogene inudces epithelial-mesenchymal transition through LATS1 down-regulation in ovarian cancer

    Hiroshi Yagi, Ichiro Onoyama, Kazuo Asanoma, Keisuke Kodama, Masafumi Yasunaga, Tatsuhiro Ohgami, Kenzo Sonoda, Kiyoko Kato

    2018.5 

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    Event date: 2018.5

    Language:English  

    Country:Japan  

  • The pivotal role of LATS1 in ovarian cancer progression

    Hiroshi Yagi, Keisuke Kodama, Masafumi Yasunaga, Tatsuhiro Ohgami, Ichiro Onoyama, Kazuo Asanoma, Kenzo Sonoda, Kiyoko Kato

    2017.5 

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    Event date: 2017.5

    Language:English  

    Country:Japan  

  • LATS1 phosphorylation at serine 909 by Ga13 is involved in YAP activation in ovarian cancer cells

    2016.4 

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    Event date: 2016.4

    Language:English  

    Country:Japan  

  • 癌の浸潤、転移におけるCXCR4/Ga13/Rhoシグナル経路の役割

    八木裕史、園田顕三、小林裕明、和氣徳夫

    第64回日本産科婦人科学会学術講演会  2012.4 

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    Event date: 2012.4

    Venue:神戸市   Country:Japan  

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MISC

  • Potential for molecularly targeted therapy against epidermal growth factor receptor ligands Reviewed

    Miyamoto S, Fukami T, Yagi H, Kuroki M, Yotsumoto F

    Anticancer Res   2009.5

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Heparin-binding epidermal growth factor-like growth factor as a new target molecule for cancer therapy Reviewed

    Miyamoto S, Yagi H, Yotsumoto F, Kawarabayashi T, Mekada E

    Adv Exp Med Biol   2008.6

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1007/978-0-387-68969-2_23.

  • Heparin-binding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy Reviewed

    Miyamoto S, Yagi H, Yotsumoto F, Kawarabayashi T, Mekada E

    Cancer Sci   2007.11

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • New approach to cancer therapy: heparin binding-epidermal growth factor-like growth factor as a novel targeting molecule Reviewed

    Miyamoto S, Yagi H, Yotsumoto F, Horiuchi S, Yoshizato T, Kawarabayashi T, Kuroki M, Mekada E

    Anticancer Res   2007.11

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • HB-EGF is a promising target molecule for ovarian cancer

    Miyamoto S, Yagi H, Tanaka Y

    Fukuoka Igaku Zasshi   2004.11

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

Professional Memberships

  • 日本癌学会

  • 日本婦人科腫瘍学会

  • 日本産科婦人科学会

  • 日本癌治療学会

Research Projects

  • 婦人科がんの発生および悪性形質獲得における三量体Gタンパクの役割

    Grant number:21K09496  2021 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 婦人科悪性腫瘍の進展におけるGa13の役割

    2018.6

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    Authorship:Principal investigator 

  • 婦人科悪性腫瘍の進展におけるGα13の役割

    Grant number:17K11282  2017 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 婦人科悪性腫瘍の転移を制御するGPCRシグナルの解析

    Grant number:26861332  2014 - 2015

    科学研究費助成事業  若手研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 婦人科癌の転移におけるGPCRの役割

    2012.9

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    Authorship:Principal investigator 

  • 婦人科悪性腫瘍の転移を制御するシグナル伝達経路の解析

    Grant number:24791709  2012 - 2014

    科学研究費助成事業  若手研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

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Award for Educational Activities

  • なし

       

Class subject

  • がん専門医師養成科目

    2023.4 - 2023.9   First semester

  • がん専門医師養成科目

    2022.4 - 2022.9   First semester

  • がん専門医師養成科目

    2021.4 - 2021.9   First semester

  • がん専門医師養成科目

    2019.4 - 2019.9   First semester

  • がん専門医師養成科目

    2018.4 - 2018.9   First semester

  • 保健学科、母体疾病論

    2018.4 - 2018.9   First semester

  • 保健学科、高次助産学演習

    2018.4 - 2018.9   First semester

  • 保健学科、母性疾病論

    2017.4 - 2017.9   First semester

  • 保健学科、高次助産学演習

    2017.4 - 2017.9   First semester

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Travel Abroad

  • 2007.10 - 2010.11

    Staying countory name 1:United States   Staying institution name 1:米国国立衛生研究所

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Surgical Clinical Medicine / Obstetrics and Gynecology

Clinician qualification

  • Specialist

    Japan Society of Obstetrics and Gynecology(JSOG)

  • Preceptor

    Japan Society of Obstetrics and Gynecology(JSOG)

Year of medical license acquisition

  • 2001